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bio~tolerance
club / casual
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ibtisam.midlet 26-Jul-22 11:42 AM
!matrix approve
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matrix-appservice-discord-t2bot BOT 26-Jul-22 11:42 AM
Thanks for your response! The matrix bridge has been approved.
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ibtisam.midlet 26-Jul-22 11:42 AM
baby
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Lux ✨ 26-Jul-22 12:33 PM
works now
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ibtisam.midlet 26-Jul-22 12:36 PM
Nicee
12:36
My server advance me lol
12:37
Need a mods
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le_drig 26-Jul-22 12:38 PM
hi
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Lux ✨
works now
ibtisam.midlet 26-Jul-22 12:38 PM
How to make invite links show in public server board
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le_drig
hi
ibtisam.midlet 26-Jul-22 12:39 PM
It seems you installed a greeting bot
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le_drig 26-Jul-22 12:39 PM
ye
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ibtisam.midlet 26-Jul-22 12:39 PM
How to do that
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ibtisam.midlet
How to make invite links show in public server board
Lux ✨ 26-Jul-22 12:49 PM
on disboard?
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elena.final_fail 26-Jul-22 12:57 PM
i logged with other account and able to get invite link
12:58
but its defernce is this okay?
12:59
i would add it to disboard and top.gg
12:59
just let see how things go now
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ibtisam midlet BOT 26-Jul-22 01:40 PM
Text from matrix
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ibtisam.midlet 26-Jul-22 02:14 PM
/batch watch challenges
14:15
/threads
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ibtisam.midlet 26-Jul-22 03:09 PM
okay made a subreddit for this server
15:10
to make sure we will not loss contact
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Pax1l 26-Jul-22 03:39 PM
@Lux ✨ havent seen you for a bit
yam joined the server. 26-Jul-22 07:21 PM
Mado joined the server. 26-Jul-22 07:42 PM
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Mado
Joined the server.
ibtisam.midlet 26-Jul-22 07:43 PM
ibtisam.midlet pinned a message to this channel. 26-Jul-22 08:31 PM
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yam 27-Jul-22 02:00 AM
What are the bots job here
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ibtisam.midlet 27-Jul-22 02:00 AM
bumping the server automatically
02:00
Or I'll use node.js
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ibtisam.midlet 27-Jul-22 02:16 AM
I disabled welcoming messages to not bother user until I found how to make it exclud bots
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Pax1l
@Lux ✨ havent seen you for a bit
Lux ✨ 27-Jul-22 02:29 AM
I’ve been moving out to another country
❤️ 1
02:29
lots of packing driving and unpacking
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machineyadav 27-Jul-22 02:29 AM
Hmmmm
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ibtisam.midlet 27-Jul-22 07:15 AM
ಠ_ಠ
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Leonardo Ruilova BOT 27-Jul-22 11:21 AM
Greetings from South America, I am a physically disabled open source user who loves biohacking
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Leonardo Ruilova
Greetings from South America, I am a physically disabled open source user who loves biohacking
ibtisam.midlet 27-Jul-22 11:38 AM
Hiiiii welcome!!!
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Leonardo Ruilova
Greetings from South America, I am a physically disabled open source user who loves biohacking
ibtisam.midlet 27-Jul-22 11:39 AM
What is your interest in biohacking exactly +_+
11:40
Hope you are life satisfied in way or other
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Leonardo Ruilova
Greetings from South America, I am a physically disabled open source user who loves biohacking
ibtisam.midlet 27-Jul-22 12:24 PM
Image attachment
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MEE6 BOT 27-Jul-22 12:24 PM
GG @ibtisam.midlet, you just advanced to level 4!
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ibtisam.midlet 28-Jul-22 01:10 AM
https://discord.com/channels/1001420842179239936/1001422332335767664
01:11
@Pax1l any addition
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Potential 28-Jul-22 05:55 AM
Greetings @everyone
♥️ 3
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Potential
Greetings @everyone
ibtisam.midlet 28-Jul-22 05:58 AM
Hiiiiiii welcome +_+ you could travel the channels to see if you can benefits or help in something and read rules
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MEE6 BOT 28-Jul-22 05:58 AM
GG @ibtisam.midlet, you just advanced to level 5!
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Maevoleth 28-Jul-22 11:55 PM
Hey guys
23:57
New to the idea of altering my body positively. I've been addicted to some substances for about a decade now, and i'm on anti-psyche medication. Hoping biohacking and something like neuralink in future can help me regulate my chemicals but for now i'm looking here
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ibtisam.midlet 29-Jul-22 12:09 AM
NAD+ IV has shown to decrease heroin intake by 80%
00:11
psychedelics has anti addiction effect proposed generally
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Maevoleth
Hey guys
ibtisam.midlet 29-Jul-22 12:19 AM
what's your addiction exactly
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Maevoleth 29-Jul-22 04:29 PM
THC, Nicotine and Caffeine
16:29
Used to be on ritalin but no longer
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Maevoleth
Used to be on ritalin but no longer
ibtisam.midlet 29-Jul-22 04:57 PM
That's not an addiction that life improving 😂
16:58
Anyway coffee should not be counted But nicotine switch to vap I think it mostly you are addicted to hand to mouth move more then effect of nicotine if any This really hard to fix, due being dalta fos be has did positive reinforcements where he eliminated you ability to feel that bad smell of sig but made the spicy part of it more enjoyable by rewards sensitation , the same for vaping, when I get bored it almost impossible for me to stop thinking about nicotinic I'll just start generation unfair selective agreement advocate nicotine use.
16:58
The problems with full of this is dalta fos b has half life ~4months That mean you need to stop for 4 months (no source its my xp) for craving potency to decrease "really" to half Which we can't even stop for few weeks do to logic changes.
16:59
To this point there is not noticeably effective dfos b inhibitor. For me D3 antagonists was useless in this regard
16:59
You might just try your luck with NAD+, just learn to inject first, small step by step and you done it.
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Sexy Seojin 30-Jul-22 04:24 AM
It’s SEOJIN!
😍 1
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Sexy Seojin
It’s SEOJIN!
ibtisam.midlet 30-Jul-22 04:47 AM
Look at emojis I stole Instagram one emoji_1
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Sexy Seojin 30-Jul-22 05:08 AM
🐤
05:09
My signature emoji
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ibtisam.midlet 30-Jul-22 05:31 AM
You will get a lot of boys running over you with this
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Sexy Seojin 30-Jul-22 09:08 AM
The hell..
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Sexy Seojin
The hell..
ibtisam.midlet 30-Jul-22 09:21 AM
this happen to voxelite, and constantly happen to me
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MEE6 BOT 30-Jul-22 09:21 AM
GG @ibtisam.midlet, you just advanced to level 7!
Doctor Bonk joined the server. 31-Jul-22 09:31 AM
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Doctor Bonk
Joined the server.
machineyadav 31-Jul-22 11:31 AM
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machineyadav
Click to see original message
Doctor Bonk 31-Jul-22 11:32 AM
emoji_51
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Doctor Bonk
emoji_51
machineyadav 31-Jul-22 11:32 AM
I seen this emoji somewhere
11:32
Very old, very nice
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machineyadav
Very old, very nice
Doctor Bonk 31-Jul-22 11:33 AM
emoji_50
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machineyadav 31-Jul-22 11:33 AM
emoji_4
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ibtisam.midlet 31-Jul-22 11:35 AM
I stole it for sirsad server emoji_5
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ibtisam.midlet
I stole it for sirsad server emoji_5
Doctor Bonk 31-Jul-22 11:35 AM
emoji_52
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machineyadav 31-Jul-22 11:52 AM
emoji_52
supplemental syrup joined the server. 31-Jul-22 01:22 PM
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ir joined the server. 31-Jul-22 06:24 PM
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Phonesavanh 01-Aug-22 03:37 AM
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Sexy Seojin 01-Aug-22 03:37 AM
🐤
03:37
hi
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veganpermanently
Joined the server.
ibtisam.midlet 01-Aug-22 03:58 AM
03:59
Whats your news seojin
Meso joined the server. 01-Aug-22 04:33 AM
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ibtisam.midlet
Click to see original message
veganpermanently 01-Aug-22 05:47 AM
yoo
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Meso 01-Aug-22 08:08 AM
Hiiiii
Damianze joined the server. 01-Aug-22 10:58 AM
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Damianze
Joined the server.
Damianze 01-Aug-22 11:09 AM
Sticker
11:10
Anyone here take paid commissions for DIY biohacking lab works?
Mabus Tiefsee joined the server. 01-Aug-22 11:25 AM
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Meso
Joined the server.
machineyadav 01-Aug-22 12:10 PM
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ibtisam.midlet 01-Aug-22 05:07 PM
we would use this to increase toxicity threshold of NMDA/AMPA https://discord.com/channels/1001420842179239936/1001425425832091708/1003811119544152094
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Damianze 01-Aug-22 05:51 PM
How long has this server existed? Doesn't feel like many active people here
Deleted User joined the server. 01-Aug-22 06:02 PM
𝒮𝓉𝓇𝑒𝑒𝓉𝑅𝒶𝓉 •⍘• joined the server. 01-Aug-22 06:03 PM
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ibtisam.midlet 01-Aug-22 06:17 PM
Many active data here
18:17
Its few days old and things going fast
18:19
There 34 member's +_+
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𝒮𝓉𝓇𝑒𝑒𝓉𝑅𝒶𝓉 •⍘• 01-Aug-22 07:02 PM
blahajhug
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ibtisam.midlet
Many active data here
Damianze 01-Aug-22 07:42 PM
Hope we can invite more people to this group who actually has experience of lab works.
emoji_37 1
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ibtisam.midlet 02-Aug-22 03:06 AM
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03:06
First Real girl beat anime ^~^
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ibtisam.midlet 02-Aug-22 11:52 AM
potential therapy for who their problem is motivation and mood more then learning >>https://discord.com/channels/1001420842179239936/1004024673840922624
Netizenne joined the server. 02-Aug-22 12:25 PM
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Netizenne 02-Aug-22 12:26 PM
Welcome!!!!!
emoji_37 1
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ibtisam.midlet
Click to see attachment 🖼️
machineyadav 02-Aug-22 12:26 PM
Lovely
12:27
I have seen many anime to irl comparisons but this is the best
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ibtisam.midlet 02-Aug-22 12:29 PM
welcome to netizenne the most cutest noots user out there, who his tiktok short never end
Новичок joined the server. 02-Aug-22 02:58 PM
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Новичок
Joined the server.
ibtisam.midlet 02-Aug-22 07:18 PM
Maestus joined the server. 02-Aug-22 09:54 PM
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Maestus 02-Aug-22 09:55 PM
🍕
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Maestus
Joined the server.
Maestus 02-Aug-22 09:55 PM
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Maestus 02-Aug-22 10:14 PM
Hey everyone, it's nice to be here.
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Maestus 02-Aug-22 10:23 PM
This place is incredible.
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emoji_37 1
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𝒮𝓉𝓇𝑒𝑒𝓉𝑅𝒶𝓉 •⍘• 02-Aug-22 10:59 PM
i love the theme of this server...
emoji_21 1
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Maestus
Hey everyone, it's nice to be here.
ibtisam.midlet 03-Aug-22 12:18 AM
wlcm +_+
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ibtisam.midlet 03-Aug-22 01:37 PM
@everyone If you have a friend who capable to contribute in anyway, or have a problem trying to solve inviting them to the server appreciated Don't invite people who force thier opinion, or who are better at saying why things wouldn't work than how to make things work
🤝 4
Hima joined the server. 04-Aug-22 09:46 AM
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Hima
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ibtisam.midlet 04-Aug-22 10:18 AM
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ひとり joined the server. 04-Aug-22 02:48 PM
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ひとり
Joined the server.
ibtisam.midlet 04-Aug-22 04:29 PM
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halcyon joined the server. 04-Aug-22 08:20 PM
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veganpermanently 05-Aug-22 12:56 AM
@ibtisam.midlet what r u using
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ibtisam.midlet 05-Aug-22 03:17 AM
magnesium pidolate IM
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ibtisam.midlet 05-Aug-22 07:31 AM
drugging your parents is the most intelligent thing you might do in your life
👁️ 1
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ibtisam.midlet
drugging your parents is the most intelligent thing you might do in your life
Netizenne 05-Aug-22 07:51 AM
I’ve been thinking about trying this (edited)
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valentino 05-Aug-22 07:51 AM
😭
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Netizenne 05-Aug-22 07:52 AM
Alzheimer’s runs in my family amoung the women My mom could use DFO or something
07:52
She’s gone vegetarian though so she might have reduced her iron anyways as is (edited)
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ibtisam.midlet 05-Aug-22 07:53 AM
It's highly beneficial especially for bisexual and sub's users
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MEE6 BOT 05-Aug-22 07:53 AM
GG @ibtisam.midlet, you just advanced to level 9!
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ibtisam.midlet
It's highly beneficial especially for bisexual and sub's users
Netizenne 05-Aug-22 07:54 AM
???!???
07:54
Why what
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ibtisam.midlet 05-Aug-22 07:55 AM
Parents will always try to force their outdated standards on you saying biology is waste of time, then you use this biology
07:55
Who the winer now
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Netizenne
Why what
ibtisam.midlet 05-Aug-22 07:58 AM
Homo/bi have a hard time generally with parent due they don't want to understand that sexual ordination is a thing
07:58
Also drug users ofc
07:59
And religious leave
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valentino 05-Aug-22 07:59 AM
what
08:01
emoji_51
❤️ 2
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ibtisam.midlet 05-Aug-22 08:01 AM
its not their life its your life, I'll kill for freedom
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machineyadav 05-Aug-22 08:01 AM
emoji_51
❤️ 2
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ibtisam.midlet 05-Aug-22 08:05 AM
The must stupid type is that parents who see you as project, give it money in childhood and he return it then
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valentino 05-Aug-22 08:07 AM
sounds like my mom
emoji_1 1
08:07
I can't wait to leave my moms place
08:08
goodbye she annoying asf she can be helpful but she really be drivin me up the wall
💯 1
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MEE6 BOT 05-Aug-22 08:08 AM
GG @valentino, you just advanced to level 1!
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valentino
goodbye she annoying asf she can be helpful but she really be drivin me up the wall
ibtisam.midlet 05-Aug-22 08:10 AM
She should support you, don't let her bother you much, otherwise you hit a point where there is no forgiveness (edited)
08:10
Better live alone if you can, and stay in contact with her
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Netizenne
She’s gone vegetarian though so she might have reduced her iron anyways as is (edited)
ibtisam.midlet 05-Aug-22 08:16 AM
I'm considered the freelancer doctor in my family lol
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ibtisam.midlet
She should support you, don't let her bother you much, otherwise you hit a point where there is no forgiveness (edited)
valentino 05-Aug-22 08:26 AM
yes
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veganpermanently 05-Aug-22 08:27 AM
Leave your fam
08:27
Never answer phone calls
08:27
Never visit
08:27
Disappear
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valentino 05-Aug-22 08:27 AM
one day once i get enough money ill move north from where from my current location
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veganpermanently 05-Aug-22 08:28 AM
Go tell the police not to react if they report you missing
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valentino 05-Aug-22 08:28 AM
no she knows I want to move out but im just broke atm trying to get my self together (edited)
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veganpermanently 05-Aug-22 08:29 AM
That wasn't advice to u
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MEE6 BOT 05-Aug-22 08:29 AM
GG @veganpermanently, you just advanced to level 1!
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veganpermanently 05-Aug-22 08:29 AM
It's advice to all men
❤️ 1
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valentino 05-Aug-22 08:29 AM
lok
08:29
ok
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veganpermanently 05-Aug-22 08:31 AM
Also
08:31
If u want some dignity
08:31
Refuse all inheritance
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ibtisam.midlet 05-Aug-22 08:35 AM
You can just drug them with some Empathogen meds
08:35
Now my breakfast reach me to bed
08:41
motomoto joined the server. 05-Aug-22 09:34 AM
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motomoto
Joined the server.
ibtisam.midlet 05-Aug-22 10:32 AM
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veganprimate
Joined the server.
ibtisam.midlet 05-Aug-22 10:32 AM
Deleted User joined the server. 05-Aug-22 02:49 PM
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Deleted User 05-Aug-22 10:41 PM
Stack post tiiiime
22:41
Prepare yourself
22:41
Rapamycin Aniracetam Piracetam Bromantane Bacopa 24% bacosides 100 mg modafinil Curcumin Cacao Ginkgo biloba Quercetin with bromelain ALCAR Na r ala Reduced glutathione NAC Agmatine Shiitake mushroom Enteric coated peppermint Digestive enzymes for all the aforementioned L-glutamine B12 sublingual methylcobalmin B6 p5p sublingual Thiamine hcl Methylfolate Potassium citrate Boron Selenium Molybdenum One meal a day
22:41
The stack is for inducing extremely high pattern recognition, synesthesia, enjoyment of life which will assess my addictive tendencies, socialization skills. The stack is clearly higy effective as i just typed all this after being up for 42 hrs straight and I worked 9 hrs at the beginning of starting this wakefulness I am impaired by high functioning autism, severe adhd and I have brain hypertension which inhibits traditional stimulants from being useful, depression, anxiety, addiction, immunocompromization (I've had molluscum contagiosum for about 4 years), chronic fatigue
22:42
I am, quite obviously, attempting to assess every issue I have in my life
22:42
My work performance has also obviously improved and I'm getting a raise soon
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Deleted User 05-Aug-22 10:51 PM
I also did a cerebrolysin cycle 4 months ago that seemed to fix my severe visual sensory issues
22:51
I also quit a 1-4 grams per day phenibut habit 5 weeks ago w minimal wd using majority of aforementioned stack
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ibtisam.midlet 05-Aug-22 10:52 PM
[Detailed Info about each needed]
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Deleted User 05-Aug-22 10:53 PM
Yea I'll do that and doses after I fucking sleep lmfao
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ibtisam.midlet 05-Aug-22 10:53 PM
All of them at once? Microcoding, co-factor problem, crazy half life, there just 3 considered something others can't suck dick of coffee (edited)
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Deleted User 05-Aug-22 10:54 PM
Normally I wouldn't even go this far but I was in the mood
22:54
Wat
22:54
How do you suck coffee penis
22:54
Tell me the ways of jedi
22:54
Most of em at once yea
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MEE6 BOT 05-Aug-22 10:54 PM
GG @Deleted User, you just advanced to level 1!
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Deleted User 05-Aug-22 10:54 PM
Bet
22:54
I'm pro
22:54
Fuck me I'm not even tired
22:54
I haven't even taken modafinil for 38 hrs
22:55
And it was 100 mg
22:55
Oh yea, fhe list is order of importance
22:55
That should help some
22:55
I listed my issues, one should be able to deduce what I'm using everything for
22:55
Er
22:55
Many things at least
22:55
Obvi most are multi faceted
22:56
I'll also add that my main strengths are long term iq and pattern recognition
22:56
Short term memory has been greatly improved by using mild 5ht2a agonists like aniracetam and agmatine
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ibtisam.midlet 05-Aug-22 10:57 PM
Thats Ampa and nmda-
22:58
To archive noticeable effect on ht2a upper dose by 200
22:58
The selective targeted not dirty drug
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Deleted User 05-Aug-22 10:59 PM
Cacao makes aniracetam 5ht2a effects more prominent
22:59
Aniracetam is placebo without cacao
23:00
It upregulates some serotonin, I'll send study after I sleep
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Deleted User
Rapamycin Aniracetam Piracetam Bromantane Bacopa 24% bacosides 100 mg modafinil Curcumin Cacao Ginkgo biloba Quercetin with bromelain ALCAR Na r ala Reduced glutathione NAC Agmatine Shiitake mushroom Enteric coated peppermint Digestive enzymes for all the aforementioned L-glutamine B12 sublingual methylcobalmin B6 p5p sublingual Thiamine hcl Methylfolate Potassium citrate Boron Selenium Molybdenum One meal a day
ibtisam.midlet 05-Aug-22 11:00 PM
Moda agmatine and mushroom, that the only will work
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Deleted User 05-Aug-22 11:00 PM
That's simply wrong
23:00
Aniracetam is potent for me
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ibtisam.midlet 05-Aug-22 11:00 PM
I took 260+ sub's
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Deleted User 05-Aug-22 11:00 PM
With all the interactions going on it'd be foolish to assume some of the norms apply
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ibtisam.midlet 05-Aug-22 11:01 PM
I have detailed data about each
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ibtisam.midlet
I took 260+ sub's
Deleted User 05-Aug-22 11:01 PM
Subs?
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ibtisam.midlet 05-Aug-22 11:01 PM
Substance
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Deleted User 05-Aug-22 11:01 PM
That's too many
23:01
Even imo
23:03
I do miss etiz for brain hypertension ngl
23:03
Surprisingly effective
23:04
Why is rapamycin so fucking stim
23:04
Half life ig
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ibtisam.midlet 05-Aug-22 11:13 PM
Did any of this made you clean you room (edited)
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Deleted User 05-Aug-22 11:15 PM
Yea but then I got it dirty again lmao
23:15
And haven't bothered since
23:15
I clean the store at work amazing
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Deleted User
I do miss etiz for brain hypertension ngl
ibtisam.midlet 05-Aug-22 11:15 PM
Hypochondria
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Deleted User 05-Aug-22 11:15 PM
But i still don't see a point in cleaning my room
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ibtisam.midlet
Hypochondria
Deleted User 05-Aug-22 11:15 PM
Making assumptions w inadequacy info
23:16
Prove to me benzos aren't anti hypertensive then get back to me
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ibtisam.midlet 05-Aug-22 11:16 PM
You don't have hypertension imo
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Deleted User 05-Aug-22 11:17 PM
I'm open to debate but only if it's hempfil
23:17
Lmao
23:17
Useless server ig
23:17
L8r
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MEE6 BOT 05-Aug-22 11:17 PM
GG @Deleted User, you just advanced to level 2!
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Deleted User 05-Aug-22 11:17 PM
Your assuming you know my life when you've talked to me for 60 min of my life total
23:17
You realize the arrogance in doing that right?
23:18
Sirsad levels
emoji_52 1
23:18
Rip you
23:18
I'm sorry i can fix my problems and you cant
23:18
I'm arrogant im
23:18
Ik
23:18
But I demonstrate actions to prove it
23:19
I'm welcome to talk but not if you don't listen to what I say
23:19
Lmk if you wanna listen, for now I'm just gonna keep working on myself
23:21
I like you, but I don't like when people don't try and view things objectively or try and understand a situation
23:21
And instead just assume, hurt aforementioned person, then go on with life w no care
23:21
I actually did have hypochondria at a point
23:21
So what, I havent in 3 years
23:22
Try and use that to support your claim idrk
23:22
Do you know why all hypertensives cause me severe headaches and make me tired? Unless I take anti hypertensives to assess the issue?
23:22
Give me an answer and I'll thoroughly consider it
23:23
I've been investigating this myself for 6 months and not on my own, bc they would be useless bc self bias
23:23
No one has a better idea
23:23
So shoot your load
23:23
You don't even know the health issues I've been through lmao
23:24
Why does lad cause me a severe headache that makes me unable to think regardless of how many 5ht2c antagonists I take
23:25
I can go on
23:25
But I'm bored
23:25
And this is futile it appears
23:25
All I can do is what I've been doing, but if you genuinely have ideas please let me know
23:25
I am open to constructive criticism
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ibtisam.midlet 05-Aug-22 11:25 PM
Look
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Deleted User 05-Aug-22 11:25 PM
I am, however, not open to destructive criticism
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ibtisam.midlet 05-Aug-22 11:26 PM
What symptoms you have from this list
23:27
ocd Perfectionism Fast talking Mania Addiction Hypochondria Hyperactivity Attention deficits Impaired productivity
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Deleted User 05-Aug-22 11:27 PM
Most of thats more adhd symptoms than hypochondriac
23:28
I never fast talk or get mania unless I take rapamycin
23:28
Hence why you've never seen me doing what I'm doing rn
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ibtisam.midlet 05-Aug-22 11:28 PM
you do it now
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Deleted User 05-Aug-22 11:28 PM
And?
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ibtisam.midlet 05-Aug-22 11:28 PM
😅
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Deleted User 05-Aug-22 11:28 PM
Bro
23:28
Your determining I have hypochondria from one altered state
23:29
When I have 6 months of looking into my issue being brain hypertension and getting support
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ibtisam.midlet 05-Aug-22 11:29 PM
The best treatment for me was risperidone 0.33mg
23:29
It will treat the real problem that induced all of this
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Deleted User 05-Aug-22 11:29 PM
Why would I kill my cognition when I finally improved it after 3 years?
23:29
Smh
23:29
Your too biased
23:30
I've tried seroquel fwiw
23:30
Not risperidone to be fair
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ibtisam.midlet 05-Aug-22 11:30 PM
D2 give you smartness and stole all other life expect from you
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Deleted User 05-Aug-22 11:30 PM
Your assuming way too much for something you know nothing abt
23:30
I take no d2ergics except aniracetam rn I believe
23:31
You can vet that claim
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ibtisam.midlet 05-Aug-22 11:31 PM
Only ris are selective in D2 and it will lost it if you go over 0.33
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Deleted User 05-Aug-22 11:31 PM
Bro you can't even type
23:31
And you've said like 8 statements
23:31
And you think your suggestion will fix my issue when your demonstrating as much issue
23:31
I'll try somn you suggest but not pharma route
23:32
So suggest an alt
23:32
Idk if relevant but I normally sleep 10 hrs a day
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ibtisam.midlet 05-Aug-22 11:32 PM
Its unfair to force someone on something even if I'm not just sure, I'm one of them
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Deleted User 05-Aug-22 11:32 PM
I haven't been able to research In 3 years
23:33
I've researched more today than past months
23:33
Past 2 days*
23:33
Apologies
❤️ 1
23:33
I'm sorry I'm getting heated
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ibtisam.midlet 05-Aug-22 11:33 PM
Its mild d2 blockage
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Deleted User 05-Aug-22 11:33 PM
I like you and I don't want to argue
23:33
How about this
23:33
I'll look into your ideas
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MEE6 BOT 05-Aug-22 11:33 PM
GG @Deleted User, you just advanced to level 3!
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Deleted User 05-Aug-22 11:33 PM
But I can't get a risp script rn
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ibtisam.midlet 05-Aug-22 11:34 PM
Wait
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Deleted User 05-Aug-22 11:34 PM
Bc I may lose my amp script which I sell for 450 a month
23:34
And I need that money for noots
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Deleted User
Bc I may lose my amp script which I sell for 450 a month
Deleted User 05-Aug-22 11:34 PM
That's fictional I could never be a drug dealer idk where the 450 a month comes from
23:35
What's funny is on any other day I would have just left this server bc this uhhh argument? But today I can actually explain my thoughts
23:35
It's a new feeling
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ibtisam.midlet 05-Aug-22 11:35 PM
https://www.alldaychemist.com/risnia-1-mg.html
Risnia 1 mg Online | Buy At AlldayChemist
Buy Risnia 1 mg online from AllDayChemist - your most reliable online pharmacy. Avail best price in USA, by your doorsteps. Order Now!
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Deleted User 05-Aug-22 11:35 PM
Ugh I gotta buy a po box again reee
23:36
Oh well I need more moda anyways
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ibtisam.midlet 05-Aug-22 11:36 PM
Start 0.25 or you will get tortured by it
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Deleted User 05-Aug-22 11:36 PM
I quit memantine a month ago btw fwiw
23:36
It started causing brain fog
23:36
Wouldn't that downregulate d2 if anything?
23:36
Chronic use I mean
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ibtisam.midlet 05-Aug-22 11:37 PM
It will cause short term upregulation
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Deleted User 05-Aug-22 11:37 PM
Define short
23:37
Bc it's been at least 4 weeks
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ibtisam.midlet 05-Aug-22 11:37 PM
Aka withdrawal symptoms
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Deleted User 05-Aug-22 11:37 PM
And I don't take uridine
23:37
I don't get mem wd
23:37
I just nic becoming stronger
23:37
I was surprised wds from gabaergics didn't get worse when I quit it
23:38
I'll also mention phenibut doesn't help with the presumed hypertension headaches
23:38
And if hypochondriac it should?
23:39
And alcohol also worsens them
23:39
Only benzos help
23:39
Of gaba drugs
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ibtisam.midlet 05-Aug-22 11:41 PM
You talk much switching from topic to topic, causing people see you annoying= no relationships
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Deleted User
Of gaba drugs
ibtisam.midlet 05-Aug-22 11:41 PM
Directly Block d2 stimulant anxiety
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Deleted User 05-Aug-22 11:42 PM
I didn't get stim anxiety all my life until a complicated health incident
23:42
In fact I had panic attacks going to school if I didn't take my adderall
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ibtisam.midlet
You talk much switching from topic to topic, causing people see you annoying= no relationships
Deleted User 05-Aug-22 11:42 PM
Untreated adhd + hypo(mania)?
23:42
That makes as much sense imo
23:43
However your right ppl have been less prone to talk to me the past 12 hrs
23:43
Idk I just think there's a lot of other options to consider
23:43
Why so focused on hypochondriac in particular is my main question
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ibtisam.midlet 05-Aug-22 11:44 PM
Because I have that
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Deleted User 05-Aug-22 11:44 PM
Which means it's a very biased suggestion
23:44
Hence why I kinda raged
23:44
I hate biases
23:45
I genuinely have hypertension if I don't take herbs for it
23:45
That's easily determinable
23:45
140/115 range
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ibtisam.midlet 05-Aug-22 11:45 PM
Tested?
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Deleted User 05-Aug-22 11:45 PM
Body hypertension is easy to asses
23:45
Yes
23:46
Doctors literally were concerned abt my blood pressure but always attributed it something else, like thay I was in the heat for an hr before coming in
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ibtisam.midlet 05-Aug-22 11:46 PM
140/115 is not considered hypertension
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Deleted User 05-Aug-22 11:46 PM
But it's always abt that high if i dont take strong anti hypertensive herbs
23:46
Well it's elevated regardless
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ibtisam.midlet 05-Aug-22 11:47 PM
And I took ris and it caused severe hypotention
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Deleted User 05-Aug-22 11:47 PM
If it was hypochondriac than shouldnt every substance I take make me feel a headache?
23:47
Ok explain to me risps pharma aside from D2
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ibtisam.midlet 05-Aug-22 11:47 PM
Which mean D2 control blood pleasure , increase blood pleasure when agonised
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Deleted User 05-Aug-22 11:47 PM
Hmmm
23:47
I want a study for thag claim
23:48
That's more extrapolated than my belief
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Deleted User
Ok explain to me risps pharma aside from D2
ibtisam.midlet 05-Aug-22 11:48 PM
Just don't take more then 0.33mg or you will lost all your biohacking interest, 2mg and you are a Farmer
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Deleted User 05-Aug-22 11:48 PM
Helps irritability associated with autistic disorder.
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ibtisam.midlet 05-Aug-22 11:48 PM
It lower your standards like nothing
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Deleted User 05-Aug-22 11:48 PM
Now I will agree thay currently I do suffer from that
23:49
Should have led with that
23:49
And also I understand I need to take suggestions from friends more bc they are often righr
23:49
However I am arrogant but working on it
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ibtisam.midlet 05-Aug-22 11:49 PM
Sighlightly Lower standards the you now are good, at least you will accept to fuck the shemale you talked about even if it was not 100% perfect
23:50
D2 is destroying all your life expect and you still advocating it
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Deleted User 05-Aug-22 11:50 PM
Yea sirs told me the same but why do they cause motivation to do shit I need to do then
23:51
Like a college application
23:51
Everything I've read says d2 bad but everything I experience says d2 good
23:51
I've been quite confused abt that
23:51
Admittedly
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ibtisam.midlet 05-Aug-22 11:51 PM
its just increase motivation for science
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Deleted User 05-Aug-22 11:52 PM
AND I HAVE NO MOTIVATION FOR ANYTHINF NORMALLY
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MEE6 BOT 05-Aug-22 11:52 PM
GG @Deleted User, you just advanced to level 4!
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Deleted User 05-Aug-22 11:52 PM
I literally sit around and watch TV all day normally
23:52
And shitpost
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ibtisam.midlet 05-Aug-22 11:52 PM
You are driving you hit someone killed it, because your was thinking about biology when you drive
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Deleted User 05-Aug-22 11:52 PM
It helps me when I'm at that point but your likely right that I can get better by dropping the d2 increasers now bc other issues have been assesed
23:53
It was likely just a helpful cope when I was at my worst
23:53
If this is accurate
23:53
Which that I can agree with accepting as a high possibility
23:53
You gotta lead with this shit tho lmao
23:53
Don't save the good shit for the end
23:53
I literally was abt to leave a while ago
23:54
And now I'm glad I've stayed bc DISCOVERY REQUIRES EXPERIMENTATION
23:54
And actually I've always liked you
23:54
If someone else had approached like this I would have left
❤️ 1
23:54
Hence excess d2 increasing autism irritability
23:57
But I already had that autism connection meme w you
23:57
I'm very glad this went well, that's a new one
23:57
Tbf when I don't take anything for d2 I just remain neutral in these things
23:58
And ignore em
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ibtisam.midlet 05-Aug-22 11:59 PM
You can go to any doctor say you was on ris and anafranil and he will prescript it for you
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Deleted User 06-Aug-22 12:00 AM
But I've had same doc for numerous years
00:00
What's anafranil?
00:01
Also I'm concerned abt risperidone inverse serotonergic action but I'm noob on inverse agonism
00:01
I have to cuck 5ht2c
00:01
And need 5ht2a uncucked
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ibtisam.midlet 06-Aug-22 12:03 AM
Ris should not be take by other people in any situation (edited)
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Deleted User 06-Aug-22 12:04 AM
Ik
00:04
Hence concern
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ibtisam.midlet 06-Aug-22 12:05 AM
You need to put your D2 on 6/10 You are 9/10 other people are 5/10 (edited)
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Deleted User 06-Aug-22 12:06 AM
I get that
00:06
But answer aforementioned q
00:07
The inverse serotonergic agonism
00:07
Wat I expect from that
00:07
Subjectively
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ibtisam.midlet 06-Aug-22 12:08 AM
it block bad serotonin receptors
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Deleted User 06-Aug-22 12:08 AM
5ht2a good
00:08
5ht2c terrible
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Deleted User
Subjectively
ibtisam.midlet 06-Aug-22 12:08 AM
See receptors function db serotonin part
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Deleted User 06-Aug-22 12:08 AM
And most inverse agonism for 2a
00:09
Db?
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ibtisam.midlet 06-Aug-22 12:09 AM
serotonin receptor are ball in park
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Deleted User 06-Aug-22 12:09 AM
Elaborate
00:10
Yea they up and down-regulate like daily it seems
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veganpermanently 06-Aug-22 12:52 AM
Risperidone is poison
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Deleted User
I have to cuck 5ht2c
Deleted User 06-Aug-22 01:38 AM
agomelatine works. 1 mg subL before bed for 15 mins
❤️ 1
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Deleted User
And need 5ht2a uncucked
Deleted User 06-Aug-22 01:40 AM
memantine works. 1 mg in the morning can do oral. using more cancels the cognitive enhancement, tho it becomes nice for some introspective work about 15 mg. but I guess you know that. Anyway the 1 mg dose is nice combo with modafinil
❤️ 1
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Deleted User
Hence excess d2 increasing autism irritability
Deleted User 06-Aug-22 01:42 AM
memantine nooks my irritability. I guess the higher doses permanently teached me how to stay calm despite unwanted scenarios happening
❤️ 1
01:43
I still get irritable it's only easier to control my reaction to the emotion
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Deleted User
AND I HAVE NO MOTIVATION FOR ANYTHINF NORMALLY
Deleted User 06-Aug-22 01:43 AM
modafinil takes care of this. some weak filtered coffee. ginkgo
❤️ 1
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veganpermanently
Risperidone is poison
Deleted User 06-Aug-22 02:01 AM
https://pure.fujita-hu.ac.jp/en/publications/risperidone-an-atypical-antipsychotic-affects-the-mrna-expression
Risperidone, an atypical antipsychotic, affects the mRNA expression...
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02:01
I take this back it's kinda based
02:04
https://pubmed.ncbi.nlm.nih.gov/30282295/
Tardive dyskinesia on low dose risperidone - PubMed
Tardive dyskinesia is a neurological disorder characterised by involuntary and purposeless movements affecting any part of the body. These movements typically occur in the oro-facial area and the patient is usually unaware of them. There are inconsistent findings in the literature on the risk factor …
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Deleted User
https://pure.fujita-hu.ac.jp/en/publications/risperidone-an-atypical-antipsychotic-affects-the-mrna-expression
ibtisam.midlet 06-Aug-22 02:08 AM
When you block d2 the body notice and start up regulating dopamine by blocking its catabolism
02:08
This will lead to agonist D1
02:08
Which is fairly good
02:10
Follow @Deleted User stack as addon at least those can suck dick of coffee
02:11
What would be halpfull from me to the stack is magnesium kilo dose, see benefits and side effects
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ibtisam.midlet
When you block d2 the body notice and start up regulating dopamine by blocking its catabolism
Deleted User 06-Aug-22 02:11 AM
MAO B expression was upregulated, it did not block catabolism, it increased it
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ibtisam.midlet
What would be halpfull from me to the stack is magnesium kilo dose, see benefits and side effects
Deleted User 06-Aug-22 02:12 AM
I'd rather not
02:12
https://pubmed.ncbi.nlm.nih.gov/8717636/
GABAergic deafferentation hypothesis of brain aging and Alzheimer's...
Recent experiments have shown that: 1) A chronic 10 month daily administration to rats of the benzodiazepine (BDZ) receptor antagonist, flumazenil (FL; 4 mg/kg in drinking water), from the age of 13 through 22 months, significantly retarded the age-related loss of cognitive functions, as ascertained …
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02:12
Mg is good but the form you take is v bad
02:12
GABA transaminase inhibitor
02:12
compare effects to valproate
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Deleted User
MAO B expression was upregulated, it did not block catabolism, it increased it
ibtisam.midlet 06-Aug-22 02:17 AM
It should be the opposite
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MEE6 BOT 06-Aug-22 02:17 AM
GG @ibtisam.midlet, you just advanced to level 10!
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ibtisam.midlet 06-Aug-22 02:17 AM
Look here
02:18
DA receptor antagonists enhance the activity of AADC https://biosignaling.biomedcentral.com/articles/10.1186/1478-811X-11-34
Complexity of dopamine metabolism - Cell Communication and Signaling
Parkinson’s disease (PD) coincides with a dramatic loss of dopaminergic neurons within the substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress. Dopamine (DA) metabolism itself is strongly linked to oxidative stress as its degradation generates reactive oxygen species (ROS) and DA oxidation can lead to endogenou...
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02:18
What you think
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ibtisam.midlet
It should be the opposite
Deleted User 06-Aug-22 02:18 AM
it might be neutral effect tho, the vesicles protect against MAO B oxidation
02:19
if VMAT2 and MAO B are increased simultaneously that's a desireable state
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Deleted User
I'd rather not
ibtisam.midlet 06-Aug-22 02:19 AM
If you see something have more benefits then harm , take it
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Deleted User 06-Aug-22 02:19 AM
because it prevents autoxidation which is the worst type of dopamine metabolism
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ibtisam.midlet 06-Aug-22 02:20 AM
Give me cazino were 60% win 40% loss, I'll sell my underwear gumbel it
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ibtisam.midlet
If you see something have more benefits then harm , take it
Deleted User 06-Aug-22 02:20 AM
the problem is short term vs long term. I was taking lemonbalm daily before. felt good but looking back it took it's toll
02:21
CBD as well. all GABAergics do this. hence why I'm now recovering with GABA antagonists
02:22
I don't go by feeling anymore
02:22
I find the most optimal intervention and use that to my benefit.
02:23
it generates better cognitive and emotional states than chasing feelings in the end anyways
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MEE6 BOT 06-Aug-22 02:23 AM
GG @Deleted User, you just advanced to level 2!
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Deleted User 06-Aug-22 02:23 AM
most of what I do now has no trade off
02:24
the doses are lower than anyone else uses, for example the agomelatine. No one has done this before me yet the study is up there and the results are clear
❤️ 1
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Deleted User
the problem is short term vs long term. I was taking lemonbalm daily before. felt good but looking back it took it's toll
ibtisam.midlet 06-Aug-22 02:26 AM
Companies try to make clean substance where side effect dose is very high then good effect, you can just microdose what you want , and the longterm effect will stay good
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Deleted User
modafinil takes care of this. some weak filtered coffee. ginkgo
Deleted User 06-Aug-22 06:24 AM
Both are in my stack but I'm poor rn and only risk moda on work days until I order more
06:24
Had to cut my dose in half to 100 mg to ensure I'd have enough for a bit
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Deleted User
Had to cut my dose in half to 100 mg to ensure I'd have enough for a bit
Deleted User 06-Aug-22 06:25 AM
I take 30 mg
06:25
it works without tolerance for about a week then I stop
06:25
I just don't take daily
06:25
I surprisingly have no tolly issues w moda
06:26
I've been using 4-6x a week for a few months
06:26
well u don't take it daily
06:26
it takes a long time to develop tolerance even on such a small dose I take
06:26
Yea but I develop tolerance to substances fast so I'm still surprised
06:26
moda has a unique MoA
06:26
Inflammation is my only guess bc nmda antagonism doesn't help
06:26
it's not the DRI effect
06:26
but it is dopaminergic for sure
06:27
Yea orexin?
06:27
it's a vesicular release agent
06:27
orexin release agent as well
06:27
What I love abt it is its not really hypertensive
06:27
you have to have a lot of vesicular release to develop tolerance
06:27
it's natural in a way
06:28
Please stop talking about my vehicles in casual, it makes me uncomfortable
❤️ 1
06:28
/ s
06:28
electrically evoked monoamine release
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Deleted User
Please stop talking about my vehicles in casual, it makes me uncomfortable
Deleted User 06-Aug-22 06:28 AM
why is everyone like this
06:28
I love electricity, sometimes I put the toaster in the bath
06:28
makes me shut down
06:28
It's a funny word I'm sorry
06:28
You may continue I'm listening and will confine shitpostinf to external servers
06:29
rage quit a vegan server yesterday
06:29
if I can't geek out I won't even talk to you
06:29
idc
06:29
Oh I want you to geek out
06:29
Wait was it vegan permanently server
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Deleted User
Wait was it vegan permanently server
Deleted User 06-Aug-22 06:30 AM
i am VP
06:30
no it was some goofy vegan dating server
06:30
they don't let you use the R word on yourself
06:31
have pronoun tags
06:31
etc
06:31
they get offended by your beliefs
06:31
imagine that
06:31
I can't even identify with vegan groups nowadays
06:32
the only thing we have in common is that we avoid animal abuse
06:32
Lmao at work I say "HEY WE DONT USE THAT WORD HERE" when someone says retard
06:32
It's a kitchen
06:32
but other than that we're a diff species
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Deleted User
It's a kitchen
Deleted User 06-Aug-22 06:32 AM
kek
06:32
that's the funny part
06:33
everyone and their mother snorting K in the toilet but you can't use the R word
06:33
https://soundcloud.com/milkavelli616/geekin
Milkavelli616
GEEKIN
PRODUCED BY OMELET
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Deleted User
everyone and their mother snorting K in the toilet but you can't use the R word
Deleted User 06-Aug-22 06:34 AM
LMAO HOWD YOU KNKW I DID THIS
06:34
Nah we can use the r word
06:34
I use it
06:34
bcs it's a kitchen
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MEE6 BOT 06-Aug-22 06:34 AM
GG @Deleted User, you just advanced to level 3!
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Deleted User 06-Aug-22 06:34 AM
all kitchens are the same
06:34
drug holes
06:34
No one does dissos at my work
06:34
Even the smart mfers tried telling me nitrous can kill you easily
06:34
Everyone drinks on the job tho
06:35
And smokes
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MEE6 BOT 06-Aug-22 06:35 AM
GG @Deleted User, you just advanced to level 5!
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Deleted User 06-Aug-22 06:35 AM
well tbf it was meant as a parabole
06:35
Basic bitch shit
06:35
K is for horses.
06:35
no amph?
06:36
I did struggle to close when nearly holing on too much bathroom k once lmfao
06:36
I can't flip my amp script at work surprisingly
06:36
moda is the perfect kitchen drug
06:36
as long as the ventilation is on point
06:36
because otherwise you'll heat out quick
06:37
I need heat for cognition
06:37
I volunteer to do hoods in 105F
06:37
And that takes an hr
06:37
moda increases thermogenesis
06:37
Yea if I don't sweat I don't think well
06:37
if u have brown fat it can feel hellish
06:37
I'm white
06:38
I'm gonna guess that's not what you meant
06:38
no
06:38
it's fat with metabolic properties
06:38
kinda based
06:38
white fat browns when exposed to cold
06:39
I see
06:39
increases cold tolerance
06:39
Hmmmm
06:39
but also makes you heat out if 5ht2a is activated at high ambient temp
06:39
I used to be very tolerant to cold and hated heat
06:39
Then it flipped
06:39
u lost brown fat
06:39
When I was tolerant to cold my diet was trash
06:39
I've also ruled out thyroid ofc
06:40
drink some olive oil and spend time in a walk in freezer
06:40
Seeing as I have chronic fatigue I had to make sure I wasn't hypothyroid
06:40
fasting mimicking diet, rinse and repeat
06:40
FUCK THE WALK INS
06:40
So cold
06:40
I am doing lower fat rn bc drug test later this month but after that I'll try
06:41
I normally eat lots of peanut butter
06:41
I maintain subQ fat
06:41
these gymbros insecure idiots
06:41
if I can see my abs it's time to crush the plate
06:42
Oop
06:42
Yea my issue likely correlates to abs becoming more pronounced
06:43
I'm amazed I couldn't sleep more
06:43
Rapamycin is wack
06:43
it is
06:43
i get these stim effects as well
06:43
well no one did until I told everyone about it
06:43
I'm curious how it will impact my treatment resistant molluscum contagiosum
06:43
so I tend to think it's a meme
06:43
I had never heard of it being a stim
06:43
And my fatigue is also due to health issues
06:44
I guess it is then
06:44
was uncomfortable when I snorted it
06:44
5 mg oral is fine
06:44
So it makes sense I'd hyperrespond to this effect, and in reality it's probably also increasing my ability to get stimmed from rest of stack bc health is better
06:44
I can't afford to oral that
06:44
I'd run out fast
06:44
Do you have a source for it atm?
06:45
a bit too much autophagy paired with fasting mimicking diet tho
06:45
I need that for a bit I'd think
06:45
has muscle pains, a headache
06:45
I have a bit of cancer in my genes
06:45
but I guess it did clear some cancerous cells
06:45
yesterday I had a customer on chemo
06:45
that's horrifying
06:45
worth every intervention
06:46
But yea I stayed up for 44 hrs unintentionally bc rapa, and could only sleep 4.5
06:46
I didn't even moda yesterday
06:46
did u snort it
06:46
Yea
06:46
Also yea my mom has a rare leukemia and severely low platelet count
06:46
I don't think it's a good idea now
06:46
Her platelets were in single digits once
06:47
get some pomiferin
06:47
Amd then she got thyroid cancer
06:47
my ex had ovary cancer
06:47
emoji_51
06:48
Oof
06:48
That sounds painful
06:49
Coffee causes me headaches if I have a cup, but for some reason I need 1/4 to 1/2 cup a day for some reason
06:49
bitch gets what she deserves
👀 1
06:49
Ok it's stack time
06:49
puts on timer
06:50
I decided to stop eating after 5 pm
06:50
Any idea of ultra low dose naltrexone is a terrible idea with rapamycin
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Deleted User
I decided to stop eating after 5 pm
Deleted User 06-Aug-22 06:50 AM
That's smart
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machineyadav 06-Aug-22 06:50 AM
No idea
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MEE6 BOT 06-Aug-22 06:50 AM
GG @machineyadav, you just advanced to level 2!
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Deleted User 06-Aug-22 06:50 AM
Most ppl eat too late
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Deleted User
Any idea of ultra low dose naltrexone is a terrible idea with rapamycin
Deleted User 06-Aug-22 06:50 AM
should be good
06:51
Ok that's gonna be my final attempt to cure my viral infection
06:51
I give up if that combo w everything else I take doesn't work
06:51
It's been lime 6 years
06:51
I can't have sex bc of it
06:51
lyme disease?
06:51
I tested myself recently
06:51
negative
06:51
I may have thay too but haven't tested
06:51
But no, benign but awful molluscum contagiosum
06:52
oh
06:52
Only supposed to last behind 2 years in severely immunocomp ppl
06:52
I've had over 6
06:52
I don't have sex to prevent shit like that
06:52
past 4 years
06:52
IM A VIRGIN
06:52
had one relapse
06:52
I got an std and I'm a virgin.
06:52
regretted it instantly
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MEE6 BOT 06-Aug-22 06:52 AM
GG @Deleted User, you just advanced to level 4!
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Deleted User 06-Aug-22 06:52 AM
got up and left
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Deleted User
IM A VIRGIN
Mabus Tiefsee 06-Aug-22 06:52 AM
50 bucks and no standards can change that
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Deleted User 06-Aug-22 06:53 AM
how the fuck did you manage to remain virgin
06:53
Lmao no I'm actually hot
06:53
I've had to turn down offers for sex
06:53
ur a strong man
06:53
my guy
06:53
i thought I was monking out
06:53
I don't lift
06:53
Kek
06:53
But yea I was in my dream girls bed
06:53
u do women
06:53
She wanted it
06:54
I was too autistic to explain my situation
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Deleted User
I got an std and I'm a virgin.
Mabus Tiefsee 06-Aug-22 06:54 AM
sounds like responsible patents....
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Deleted User 06-Aug-22 06:54 AM
if everyone was like u all women would be saints
06:54
So it was just a cuddle sesh
06:54
Then she tried again in the morning lmao
06:54
Put my hands on her tits
06:54
slut
06:54
Then when I obviously wasn't gonna fuck she said she had to go see her sister
06:54
slap
06:54
spit
06:54
spank
06:54
We met at a bar so probably tbfh
06:55
That was my first time ever going to a bar and j wasn't even 21 lmao
06:55
And I went home with a 10
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Deleted User
Then when I obviously wasn't gonna fuck she said she had to go see her sister
Deleted User 06-Aug-22 06:55 AM
next Tinder match
06:55
codename
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Mabus Tiefsee 06-Aug-22 06:55 AM
the std, an incurable one?
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Deleted User 06-Aug-22 06:55 AM
Mines treatment resistant
06:55
Severely
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Mabus Tiefsee 06-Aug-22 06:56 AM
that sucks
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Deleted User 06-Aug-22 06:56 AM
Tell me abt it
06:56
I wasn't an addict until I got it
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Mabus Tiefsee 06-Aug-22 06:57 AM
trying sonething crazy to cure it with biohacking or did you acept your fate? (edited)
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Deleted User 06-Aug-22 06:58 AM
Trying something very crazy
06:59
The kitchen sink
06:59
try histidine
06:59
overload BCAAs
06:59
limit tryptophan
06:59
and bomb rapamycin oral
06:59
all at the same time
06:59
I notice serotonin upregulation worsens it
06:59
Aka cacao
07:00
indeed IDO is antiviral
07:00
nooking IDO will provide an edge to viruses
07:00
IDO?
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Mabus Tiefsee 06-Aug-22 07:00 AM
if you need any crazy new ideas, tell me the std - i always come up with crazy ideas... besides i am limited extremly with biohacking because of my country. Therefore theory and stoneage biohacking is all i got...
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Deleted User 06-Aug-22 07:00 AM
indoleamine dioxygenase
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Mabus Tiefsee
if you need any crazy new ideas, tell me the std - i always come up with crazy ideas... besides i am limited extremly with biohacking because of my country. Therefore theory and stoneage biohacking is all i got...
Deleted User 06-Aug-22 07:01 AM
It's molluscum contagiosum, you can scroll up for additional context
07:01
Current plan is focused on low dose naltrexone + rapamycin
07:01
And rest of my stack
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Mabus Tiefsee 06-Aug-22 07:02 AM
wait, it is a pocks strain? Immunity against one pocks version often helps against others. Did you already trow some close but more harmless pocks strains into the kitchen sink?
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Deleted User 06-Aug-22 07:03 AM
Uhhh no
07:03
How would I even
07:03
Buy em from Rothschild?
07:03
Lmao
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Mabus Tiefsee 06-Aug-22 07:04 AM
monkey pox home delivery service, just ask some gay dudes if they got connections. The worst orgys should have them
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Deleted User 06-Aug-22 07:05 AM
disgusting
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Mabus Tiefsee 06-Aug-22 07:05 AM
and asking your doctor for an old pox vaccine, the they could still work (first pox vaccine was just a weak pox strain. That's the reason many got a scar at the incection site)
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Deleted User
disgusting
Mabus Tiefsee 06-Aug-22 07:05 AM
yes
07:06
oh and high dose vitamin C, some cink and high dose vitamin D Just for boosting your immune system.
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Deleted User 06-Aug-22 07:06 AM
Yea i take all those
07:06
50 k IU Lesss goo
07:06
Oh I forgot to include reacta c in my stack
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Mabus Tiefsee 06-Aug-22 07:06 AM
....like i sayd, crazy ideas are my speciallity...
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Deleted User 06-Aug-22 07:06 AM
Rapamycin Aniracetam Piracetam Bromantane Bacopa 24% bacosides 100 mg modafinil Curcumin Cacao Ginkgo biloba ALCAR Na r ala Reduced glutathione NAC Shiitake mushroom Enteric coated peppermint Digestive enzymes for all the aforementioned B12 sublingual methylcobalmin B6 p5p sublingual Thiamine hcl Methylfolate Potassium citrate Boron Selenium Molybdenum One meal a day@Mabus Tiefsee
07:07
knock on wood my zoster infection hasn't returned for 4 yrs
07:07
I guess all I need to do is avoid bitches
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Mabus Tiefsee 06-Aug-22 07:07 AM
all it needed for me (even during my most horny time as teenager) for loosing all interests in her. Blisters on the lips....
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MEE6 BOT 06-Aug-22 07:07 AM
GG @Mabus Tiefsee, you just advanced to level 4!
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Mabus Tiefsee
all it needed for me (even during my most horny time as teenager) for loosing all interests in her. Blisters on the lips....
Deleted User 06-Aug-22 07:08 AM
simplex is nothing compared to zoster
07:08
zoster gives you debilitating back pain
07:08
you can't get up even
07:08
ever move is like a thousand daggers through your spine
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Mabus Tiefsee 06-Aug-22 07:09 AM
sounds awfull
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Deleted User 06-Aug-22 07:09 AM
it is evil
07:09
attacks your nerves in the spinal cord
07:09
some people have these pains permanently
07:09
and no painkiller helps it
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Mabus Tiefsee 06-Aug-22 07:10 AM
don't forget to freeze a sample of infectious material as backup plan in case you need it one day
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Deleted User 06-Aug-22 07:10 AM
nooked it with acyclovir
07:11
should probably stock up on femcyclovir in case it comes back
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Mabus Tiefsee 06-Aug-22 07:11 AM
and avoid bitches, that hour of fun is not worth any std, even the not as serious ones....
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Deleted User 06-Aug-22 07:12 AM
ofc
07:12
I'm monk
👍 1
07:12
no PMS
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Mabus Tiefsee 06-Aug-22 07:12 AM
yeah a guy has to go his own way, i agree
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Deleted User 06-Aug-22 07:13 AM
also no porn
07:13
that's literal brain damage
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Mabus Tiefsee 06-Aug-22 07:13 AM
hold on....
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Deleted User 06-Aug-22 07:14 AM
to be fair it's not really strong science but it does feel like it
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Mabus Tiefsee 06-Aug-22 07:14 AM
no women and no porn? How do you manage your hormones? I can have either or - but both, how?
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Mabus Tiefsee
no women and no porn? How do you manage your hormones? I can have either or - but both, how?
Deleted User 06-Aug-22 07:15 AM
great inhibitory control
07:15
I've upregulated my GABA neurons to the point I can enjoy not induldging compulsions in a way
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Mabus Tiefsee 06-Aug-22 07:16 AM
was it before the infection as well? Pain reducing your dribes makes sense. Otherwise you migt want to check your hormon levels. Just to be sure.
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Mabus Tiefsee
was it before the infection as well? Pain reducing your dribes makes sense. Otherwise you migt want to check your hormon levels. Just to be sure.
Deleted User 06-Aug-22 07:16 AM
no this happened only after I took my stack
07:16
before that I couldn't even manage to not smoke weed
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Mabus Tiefsee 06-Aug-22 07:17 AM
ah direct brain alteration, yeah that explains it (edited)
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Deleted User 06-Aug-22 07:17 AM
avoid GABAergics
07:17
introduce GABA antagonists and release inhibitors
07:17
result is stronger inhibitory neurotransmission over time
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Mabus Tiefsee 06-Aug-22 07:17 AM
no, can't do that. That would make reproduction difficult
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Deleted User 06-Aug-22 07:18 AM
reproduction of what
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Mabus Tiefsee 06-Aug-22 07:18 AM
human ofspring
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Deleted User 06-Aug-22 07:19 AM
I don't intend to have children but I'm curious what you're on about
07:19
I don't have a clue
07:19
https://www.youtube.com/watch?v=Qr4azoVLqL0
ThatClassicalVibe
Erik Satie - Gnossiennes 1-5 (3 hour loop)
07:20
I'm busy planning world domination I don't have time for little gremlins
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Deleted User
I'm busy planning world domination I don't have time for little gremlins
Pax1l 06-Aug-22 07:20 AM
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Mabus Tiefsee 06-Aug-22 07:21 AM
sperm donations for those who want to raise my ofspring for me minimal risk & investment, maximal offspring numbers. I am switching from a K strategy to an R strategy in reproduction. If just one out of ten children will develop good, it is a win - simple math.
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Deleted User 06-Aug-22 07:21 AM
if I can't indoctrinate them there is no point
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Deleted User
I'm busy planning world domination I don't have time for little gremlins
Mabus Tiefsee 06-Aug-22 07:22 AM
that's why i said freeze infectious tissue! Use it as starting point and make an airborn version. In case ypu need a hostage, take the whole world!
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Deleted User 06-Aug-22 07:22 AM
gremlins are ideal cult followers but you need to actually do it
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Deleted User
if I can't indoctrinate them there is no point
Mabus Tiefsee 06-Aug-22 07:23 AM
the question is, do you think nature or nurture. I believe it is 60-90% nature and the remaining nurture is neglectable.
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Mabus Tiefsee
the question is, do you think nature or nurture. I believe it is 60-90% nature and the remaining nurture is neglectable.
Deleted User 06-Aug-22 07:24 AM
nurture all the way
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Mabus Tiefsee 06-Aug-22 07:24 AM
in that case, become a teacher
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Mabus Tiefsee
in that case, become a teacher
Deleted User 06-Aug-22 07:25 AM
no that's just adding a drop to a sea it does nothing
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Mabus Tiefsee 06-Aug-22 07:25 AM
kindergardenteacher
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Deleted User 06-Aug-22 07:25 AM
I need them isolated until they're fully grown up and trained
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Mabus Tiefsee 06-Aug-22 07:26 AM
they see the children more often than the parents if you exclude sleeping time
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Deleted User 06-Aug-22 07:26 AM
I need teachers tho'
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MEE6 BOT 06-Aug-22 07:26 AM
GG @Deleted User, you just advanced to level 5!
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Deleted User 06-Aug-22 07:26 AM
hard to brainwash 10k children all by yourself
07:28
https://www.youtube.com/watch?v=AfTZ82SxvHg
Triggernometry
Jaron Lanier - The Truth About Social Media
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Deleted User
hard to brainwash 10k children all by yourself
Mabus Tiefsee 06-Aug-22 07:31 AM
tell that to pokemon. Make a game, you can hide anything in there and it works better as everything the teachers would teach anyway
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Mabus Tiefsee
tell that to pokemon. Make a game, you can hide anything in there and it works better as everything the teachers would teach anyway
Deleted User 06-Aug-22 07:32 AM
ur right should prolly take a more legally sound approach
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Mabus Tiefsee 06-Aug-22 07:33 AM
and hide the thing afzer 3h of playtime. That way the parents won't find out. The problem DnD made, they showed the satanic stuff during character creation!
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Deleted User 06-Aug-22 07:53 AM
I'm shaking
07:53
I've been on rapamycin 3 days and my viral infection I've had for 6+ years is going away
07:54
One of the largest bumps I had is just gone
07:54
GONE
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Deleted User
One of the largest bumps I had is just gone
Deleted User 06-Aug-22 07:59 AM
nice
07:59
it's potent
07:59
make sure to do other biohacks to prevent bacterial infections
08:00
S. montana oil aromatherapy
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Deleted User
GONE
Deleted User 06-Aug-22 08:05 AM
https://academic.oup.com/ijnp/article/21/6/592/4859715
Repeated Systemic Treatment with Rapamycin Affects Behavior and Amy...
AbstractBackground. Clinical data indicate that therapy with small-molecule immunosuppressive drugs is frequently accompanied by an incidence rate of neuropsych
Thumbnail
08:05
found it
08:07
Hmmmm it's anxiolytic for me
08:07
Does bring down my childhood leaning toward hypolanic bipolar
08:08
But I was in depression for past 7 years and constantly abused drugs so it's worth the trade
08:08
I also have never been diagnosed with bipolar
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Deleted User
S. montana oil aromatherapy
Deleted User 06-Aug-22 08:10 AM
Alternatives?
08:10
I'm sure I have something helpful at home
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ibtisam.midlet 06-Aug-22 08:28 AM
@Deleted User ❤
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Deleted User 06-Aug-22 08:30 AM
Hi fren
08:31
I just found 7 amp
08:31
Free money
08:31
That's literally $105 in my pocket
08:31
It's a good week
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Deleted User 06-Aug-22 08:51 AM
I also am now a synesthetic
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MEE6 BOT 06-Aug-22 08:51 AM
GG @Deleted User, you just advanced to level 6!
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Deleted User 06-Aug-22 08:51 AM
At least w current stack
08:51
Another long term goal achieved
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Deleted User 06-Aug-22 10:59 AM
Bro getting rid of this fucking nft is a huge pain
10:59
I got it for free
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Deleted User 06-Aug-22 11:09 AM
Ok I need crypto, who wants to buy piracetam or aniracetam
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Deleted User
Alternatives?
Deleted User 06-Aug-22 12:01 PM
search antiobiotic herb. I found this one to take care of Streptococcus aureus
kowau joined the server. 06-Aug-22 12:06 PM
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kowau
Joined the server.
Deleted User 06-Aug-22 12:06 PM
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Deleted User
search antiobiotic herb. I found this one to take care of Streptococcus aureus
Deleted User 06-Aug-22 12:08 PM
Oh I already cured my recurrent mrsa
12:08
I actually was getting close to needing an amputation lmfao
12:09
Entire leg was severely red and antibiotics made it spread more
12:09
the thing is
12:10
Researched and found articles on Manuka honey, asked the doctor abt it and he advised against it, did it anyways and next day doctor goes "idk what your doing but keep doing it"
12:10
Fuck doctors lmao
12:10
S. auerus is a natural part of the nasal microbiome
12:10
I'm aware
12:10
secretes toxins which directly access the brain
12:10
I meant I cured getting recurrent infections
12:10
Hm didn't know that part
12:10
which is why I wanted to nook it
12:10
and found the oil to do it
12:10
But you'd have to do that daily
12:10
Forever
12:10
And ever
12:10
And ever
12:11
ever echoing in the distance
12:11
yeah well I like S montana smell
12:11
I don't mind my house smelling like that all the time
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Deleted User
Researched and found articles on Manuka honey, asked the doctor abt it and he advised against it, did it anyways and next day doctor goes "idk what your doing but keep doing it"
Deleted User 06-Aug-22 12:12 PM
classic doctor behavior
12:12
if there's something they were not thought in school
12:12
the automatic response is to say no
12:12
true NPC behavior
12:13
tho' there may be legal liabilities about this
12:13
so that's one reason for this
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Deleted User
the automatic response is to say no
Deleted User 06-Aug-22 12:13 PM
The problem is they're also taught to do that
12:13
They're actually essentially taught not to think in a way
12:13
I ate an Arum sp. leaf once
12:13
Independently
12:13
I am a leaf
12:13
came choking to my doc
12:14
they told me 'we don't know what it is go home'
12:14
Idek what that is fam this isn't going well
12:14
Sounds right
12:14
I'm surprised they didn't just give you charcoal
12:14
They should always do that if they don't know
12:14
At worst it'll have a neutral effect
12:14
At best it'll work
12:14
that's the most poisonous plant one could consume in Europe
12:15
I could have died if I only ate a bit more
12:15
They don't have Datura in europe?
12:15
this is more poisonous than datura by far
12:15
But more fun inbet
12:15
S
12:15
nah
12:15
it just makes you choke
12:15
and you die
12:16
Some people like that tbh
12:16
Weird people
12:16
my ex
12:16
stupid bitch
12:16
What's the moa
12:16
Did u kill her
12:16
/s
12:16
idk I'll look it up
12:16
Too much kink choking
12:16
Lmfao
12:16
no she begged me
12:16
I slapped her
12:16
'why did you slap me'
12:16
'because you're a dumb bitch'
12:17
proceeds with the pounding
12:18
Thud
12:18
Thud
12:18
Thud
12:18
Door opens
12:19
wtf
12:20
the MoA is literally calcium oxalate
12:20
brazing your throat
12:21
oh
12:21
so this promotes absorption of cyanoglycosides
12:23
FUN
12:23
funny thing
12:23
my diet is literally slowly poisoning me
12:24
That's common
12:24
Too many oxalates?
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Deleted User
Too many oxalates?
Deleted User 06-Aug-22 12:24 PM
I'll eat over 2 g by the end of the day today
12:24
emoji_23
12:25
that spinach champignon stew
12:25
NOT SPINACH NOO
12:25
The fucking worst
12:25
You can literally feel the oxalates
12:26
yeah well IDC
12:26
because I made the best recipe in the world
12:26
eats more cacao
12:26
you can't go beyond this no way
12:26
I'm a cook
12:26
So your probably right
12:26
me too
12:27
but I choose not to work for a cuck
12:27
That's why you bully your coworkers into complacency ezpz
12:27
I owe lawyers and fam
12:27
Sp I got to
12:28
who did you kill
12:28
Your ex gf...
12:28
good riddance
12:28
thanks
12:29
Yea now pay up
12:29
oh
12:29
meet me in the back street
12:29
don't carry weapons
12:29
NO DONT PAY IN SEX
12:29
I need money
12:30
I'll pay in DEATH
12:30
Why does the government take your taxes just to return them at the end of the year
12:30
it does?
12:30
Uh oh I'm getting too smart
12:30
In America
12:31
idk it send me the thing about getting my tax return I never go
12:31
maybe I should
12:31
You should just get a check
12:31
Well you have to file
12:31
always thought it was a misunderstandin
12:32
Lmao
12:33
You should use turbo tax this year
12:34
I'm fairly certain your breaking the law lmfao
12:34
If you have a job
12:34
why
12:34
Bc America is dumb
12:34
I'm not in usa
12:34
Then idk
12:38
Ugh I don't wanna go to work
12:39
Wyd
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Deleted User
Wyd
Deleted User 06-Aug-22 02:12 PM
eatin spinach champignon stew
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MEE6 BOT 06-Aug-22 02:12 PM
GG @Deleted User, you just advanced to level 6!
RentableZulu joined the server. 06-Aug-22 02:49 PM
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ibtisam.midlet 06-Aug-22 02:53 PM
Hi guys @RentableZulu student have 3 diploma: have an associates in mathematics and science and a bachelors in both biology with a concentration in genetics and biochemistry
❤️ 1
14:53
Its mostly being benfitical to have at least one , a none freelancer biologist
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RentableZulu 06-Aug-22 02:55 PM
@ibtisam.midlet thank you for the introduction! I’m grateful to be part of the community and I look forward to collaborating on projects and contributing! 🙂
emoji_1 1
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ibtisam.midlet 06-Aug-22 03:00 PM
See channels to know what we are researching, if you could contribute will be awesome +_+ Or even get some unusual info might help you
❤️ 1
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RentableZulu 06-Aug-22 03:08 PM
Of course, I’ll be sure to check them out! Thanks again for the intro to the community
judas joined the server. 06-Aug-22 03:25 PM
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Deleted User
agomelatine works. 1 mg subL before bed for 15 mins
Deleted User 06-Aug-22 03:37 PM
@RentableZulu look here
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Netizenne 06-Aug-22 04:24 PM
Jesus stayed dead for atleast a quarter of a year before returning revived
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MEE6 BOT 06-Aug-22 04:24 PM
GG @Netizenne, you just advanced to level 1!
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Netizenne 06-Aug-22 04:24 PM
Rip Jesus for being chased away despair
16:24
He spoke the truth
JKL joined the server. 06-Aug-22 04:33 PM
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JKL
Joined the server.
ibtisam.midlet 06-Aug-22 08:00 PM
Sticker
maze.yaeger joined the server. 06-Aug-22 08:42 PM
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maze.yaeger
Joined the server.
ibtisam.midlet 06-Aug-22 08:42 PM
Sticker
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ibtisam.midlet 06-Aug-22 09:31 PM
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valentino 06-Aug-22 09:33 PM
Image attachment
emoji_1 1
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Deleted User 06-Aug-22 09:36 PM
Hello (edited)
21:36
How is everyone
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maze.yaeger 06-Aug-22 09:38 PM
🦧
21:38
Hi
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Deleted User 06-Aug-22 09:39 PM
I'm gonna use my based stack to date the hottest girl at work
21:39
And it's gonna work
21:39
She's a server and I'm a cook so if shit doesn't work it could be worse
21:40
What are you up to yaeger
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maze.yaeger 06-Aug-22 09:41 PM
Jaja
21:42
Hi, just looking for servers
The Blur joined the server. 06-Aug-22 09:49 PM
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The Blur 06-Aug-22 09:49 PM
Hi
21:50
Who is the leader of this domain
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Deleted User 06-Aug-22 09:52 PM
I'm top of the member list rn so I am
21:52
What do you need
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The Blur
Who is the leader of this domain
Deleted User 06-Aug-22 09:52 PM
Always assume it's the most active member
21:53
It's accurate in this case
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The Blur 06-Aug-22 09:53 PM
Good
21:54
785513382215811122
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Deleted User
that spinach champignon stew
The Blur 06-Aug-22 09:55 PM
Cadmium
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The Blur
Who is the leader of this domain
ibtisam.midlet 06-Aug-22 10:12 PM
Its me
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Deleted User 06-Aug-22 10:15 PM
Your cadmium
22:15
I knew it
Average John joined the server. 07-Aug-22 12:20 AM
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Average John
Joined the server.
Deleted User 07-Aug-22 12:39 AM
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Deleted User 07-Aug-22 03:51 AM
@ibtisam.midlet hello do you want to make a channel for hair loss
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ibtisam.midlet 07-Aug-22 03:51 AM
Nope
03:53
Its too niched
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Deleted User 07-Aug-22 06:45 AM
Take boron
06:45
Works annoyingly well for my facial hair
komodo dragon joined the server. 07-Aug-22 11:28 AM
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komodo dragon
Joined the server.
veganpermanently 07-Aug-22 11:42 AM
11:42
Yoyoyo
11:42
What's on the menu
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The Blur 07-Aug-22 11:44 AM
Not vegan food
🤣 1
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ibtisam.midlet 07-Aug-22 12:23 PM
@Deleted User go to improving >>sub>>hair loss Do your research there
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ibtisam.midlet 08-Aug-22 03:43 PM
@everyone read this if you want to stop breathing https://discord.com/channels/1001420842179239936/1006326720573481091/1006326726944632882
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ibtisam.midlet
Click to see attachment 🖼️
Potential 08-Aug-22 03:48 PM
Who is this person? You?
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ibtisam.midlet 08-Aug-22 03:50 PM
nope, but one day will do that emoji_51
emoji_12 1
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Damianze 08-Aug-22 05:45 PM
Anyone here take paid commissions for DIY biohacking lab works?
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MEE6 BOT 08-Aug-22 05:45 PM
GG @Damianze, you just advanced to level 1!
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Deleted User 08-Aug-22 06:37 PM
I'll take paid commisions
18:37
Can't say I can do the latter
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Damianze
Anyone here take paid commissions for DIY biohacking lab works?
ibtisam.midlet 09-Aug-22 01:23 AM
It seems not 🐤
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Deleted User 09-Aug-22 11:01 AM
I am glad I got a fitting role
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The Blur 09-Aug-22 11:01 AM
FUCK
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ibtisam.midlet 10-Aug-22 04:17 AM
Alyen joined the server. 10-Aug-22 07:32 AM
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ibtisam.midlet 10-Aug-22 08:07 AM
see this https://discord.com/channels/1001420842179239936/1001422133966159882/1006896315835359235
08:11
any input xx
blank joined the server. 10-Aug-22 11:10 AM
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blank
Joined the server.
blank 10-Aug-22 11:10 AM
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Alyen
Joined the server.
blank 10-Aug-22 11:10 AM
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ibtisam.midlet 10-Aug-22 11:14 AM
look who jumped
11:14
You are wlcm between
11:14
Read rules
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blank 10-Aug-22 11:14 AM
emoji_50
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ibtisam.midlet 10-Aug-22 11:14 AM
I can make you unmentionable if you want
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ibtisam.midlet
I can make you unmentionable if you want
blank 10-Aug-22 11:14 AM
wdym
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ibtisam.midlet 10-Aug-22 11:16 AM
Seems You don't like to mentioned rendomly by users
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blank 10-Aug-22 11:16 AM
😭
11:18
it doesn't actually matter
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Deleted User 10-Aug-22 11:38 AM
do you even do sublingual probiotics
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blank 10-Aug-22 11:46 AM
🤐
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MEE6 BOT 10-Aug-22 11:46 AM
GG @blank, you just advanced to level 1!
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ibtisam.midlet 10-Aug-22 12:48 PM
This will gives you nice pleasure @Pax1l https://youtu.be/Ady3Ds_n9AI
Zinah G
ترجمة اغنية جستن بيبر و will i m الجديدة that power
12:48
you got that power?
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Pax1l 10-Aug-22 12:49 PM
🤣
💯 1
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ibtisam.midlet 10-Aug-22 12:52 PM
Mr paranoid (edited)
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blank
😭
The Blur 10-Aug-22 01:59 PM
notetake
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Damianze 10-Aug-22 05:43 PM
Does anyone know how artificial eggs and sperms generate from stem cells even make sense?
17:44
Stem cells carry the full number of chromosomes in its DNA, while eggs and sperms only carry half.
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ibtisam.midlet 10-Aug-22 06:25 PM
Generated* From stem cells? If I understanded your question, then stem cells need to splited to get half DNAs like sperm and eggs
18:25
In other way if you mean how stem cells can be generated from egg and sperm or not, then just join them and you get full DNA
18:25
you can even ganerate full DNA just from half DNA (chromatid) there recessive and dominant genes there, but still not important, you can just use the same chromatid twice
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Damianze
Does anyone know how artificial eggs and sperms generate from stem cells even make sense?
Mabus Tiefsee 11-Aug-22 01:57 AM
for cloning an extinct animal, yeah maybe . For every other practical application, there are better ways
01:59
and it always depend on the goal, what do you want to achieve?
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CEO 11-Aug-22 12:51 PM
Yo
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veganpermanently 11-Aug-22 12:57 PM
CEO of CEO
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veganpermanently
CEO of CEO
diabolik 11-Aug-22 12:58 PM
yo
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diabolik
yo
veganpermanently 11-Aug-22 12:59 PM
Sup
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The Blur 11-Aug-22 01:00 PM
kannaWave
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veganpermanently 11-Aug-22 01:00 PM
Everybody here
13:00
Leave sirsa to die alone
emoji_21 1
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The Blur 11-Aug-22 01:00 PM
I heard he likes McDonald’s eSobbing
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veganpermanently
Leave sirsa to die alone
Odder_Sea (Glowie) 11-Aug-22 01:05 PM
I should have known you were orchestrating this behind the scenes, you diabolical heathen
🤣 3
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Odder_Sea (Glowie)
I should have known you were orchestrating this behind the scenes, you diabolical heathen
The Blur 11-Aug-22 01:05 PM
Who is u
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The Blur
Who is u
Odder_Sea (Glowie) 11-Aug-22 01:07 PM
I am the clown with the tear-away face
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Odder_Sea (Glowie)
I should have known you were orchestrating this behind the scenes, you diabolical heathen
Deleted User 11-Aug-22 01:47 PM
thank you for the kind words odder
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Deleted User
thank you for the kind words odder
Odder_Sea (Glowie) 11-Aug-22 01:56 PM
It's is my honor to bestow upon you my encouraging prose
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Odder_Sea (Glowie)
It's is my honor to bestow upon you my encouraging prose
Deleted User 11-Aug-22 01:57 PM
which demon suddenly imbued you with the power of silky smooth lyrical spell mastery
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Deleted User
which demon suddenly imbued you with the power of silky smooth lyrical spell mastery
Odder_Sea (Glowie) 11-Aug-22 02:01 PM
I been spitting these lyrical enigmas since I could remember
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Odder_Sea (Glowie)
I been spitting these lyrical enigmas since I could remember
Deleted User 11-Aug-22 02:02 PM
splitting minds like a sigma, makes me wanna get better
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Deleted User
splitting minds like a sigma, makes me wanna get better
Odder_Sea (Glowie) 11-Aug-22 02:05 PM
Degenerate rhymes, I'm a stigma, tell yo ho ma she can ligma (edited)
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MEE6 BOT 11-Aug-22 02:05 PM
GG @Odder_Sea (Glowie), you just advanced to level 1!
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Netizenne 11-Aug-22 02:13 PM
Guys I was just thinking about the very real danger of if we accidentally sang too much praise to novelty seeking and accidentally got everyone on noots that made them leave the server and do other stuff with their lives ;_; (edited)
14:13
We should probably nook D2/D4 to proactively prevent that imo, they are involved in novelty seeking iirc (edited)
14:14
But is the novelty seeking of D2/D4 applicable to social relations????
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Netizenne
Guys I was just thinking about the very real danger of if we accidentally sang too much praise to novelty seeking and accidentally got everyone on noots that made them leave the server and do other stuff with their lives ;_; (edited)
Odder_Sea (Glowie) 11-Aug-22 02:15 PM
Too late, fomenting a coup d'état in Nicaragua (edited)
Heartsunken 1
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Odder_Sea (Glowie)
Too late, fomenting a coup d'état in Nicaragua (edited)
Netizenne 11-Aug-22 02:15 PM
NOOOOO PepeHands
14:15
Blank and Bonk have already left nootopics for greener lands
14:16
Such damage has already been done
14:16
We need cohesion!!!!!!!
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Netizenne
Blank and Bonk have already left nootopics for greener lands
Odder_Sea (Glowie) 11-Aug-22 02:16 PM
Together? Holding hands?
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Odder_Sea (Glowie)
Together? Holding hands?
Netizenne 11-Aug-22 02:16 PM
B-team Love Love Love Love Love Love
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Odder_Sea (Glowie) 11-Aug-22 02:16 PM
Skipping into the sunset?
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Netizenne 11-Aug-22 02:16 PM
Ya exact
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MEE6 BOT 11-Aug-22 02:16 PM
GG @Netizenne, you just advanced to level 2!
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Netizenne
Guys I was just thinking about the very real danger of if we accidentally sang too much praise to novelty seeking and accidentally got everyone on noots that made them leave the server and do other stuff with their lives ;_; (edited)
Deleted User 11-Aug-22 02:19 PM
r u joking
14:19
I'm too autistic to tell
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Netizenne
We need cohesion!!!!!!!
Deleted User 11-Aug-22 02:20 PM
not on Sirsad's server
14:20
in general, yeah wouldn't hurt
14:20
with a delta male leader eh
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Netizenne
Guys I was just thinking about the very real danger of if we accidentally sang too much praise to novelty seeking and accidentally got everyone on noots that made them leave the server and do other stuff with their lives ;_; (edited)
Alyen 11-Aug-22 02:21 PM
yus
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Deleted User 11-Aug-22 02:21 PM
regarding novelty seeking
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Deleted User
r u joking
Netizenne 11-Aug-22 02:21 PM
Does it matter, there is knowledge to be gained in adopting the narrative and the motivations that come with it
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Alyen 11-Aug-22 02:21 PM
Wow u guys are super mods
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Netizenne
Does it matter, there is knowledge to be gained in adopting the narrative and the motivations that come with it
Deleted User 11-Aug-22 02:22 PM
there is no novelty seeking activity more complex than biohacking
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Alyen
Wow u guys are super mods
Netizenne 11-Aug-22 02:22 PM
I will moderate your LIFE There is no escaping this server
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Alyen 11-Aug-22 02:22 PM
lip
14:22
Ok
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Deleted User 11-Aug-22 02:22 PM
there is always new pathways
14:22
and even the old pathways always have new interactions
14:23
these people that left the space didn't do so bcs there is no more novelty in biohacking
14:23
bcs there always is and it's not even hard to come across it
14:24
so you don't even need to seek we're all just showered in novelty
14:24
these people left for 2 reasons
14:25
they got dissapointed by people or their biohacking success or scared of sides for some reason
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Netizenne 11-Aug-22 02:25 PM
Perhaps there is a sweet spot for how much novelty seeking you get. Or perhaps different pathways effect novelty seeking within different domains -like maybe oxytocin increases novelty seeking within “things” but not people. (edited)
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Netizenne
Perhaps there is a sweet spot for how much novelty seeking you get. Or perhaps different pathways effect novelty seeking within different domains -like maybe oxytocin increases novelty seeking within “things” but not people. (edited)
Deleted User 11-Aug-22 02:27 PM
seeking new people for the novelty is just low IQ
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Netizenne 11-Aug-22 02:28 PM
Idk not really Meet the right person and you can stumble upon insane wealths of knowledge
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Deleted User 11-Aug-22 02:28 PM
well yeah
14:28
but you did that for the knowledge not the person
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Netizenne 11-Aug-22 02:29 PM
Does novelty seeking, divergent thinking, creativity and aberrant synaptogenesis all have something in common???
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Deleted User 11-Aug-22 02:30 PM
can put paranoia in that category
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Netizenne 11-Aug-22 02:31 PM
I think sirsad said psychedelics cause massive aberrant synaptogenesis like it was a bad thing, -but aren’t the abnormal/divergent connections of these substances where the creativity comes from???????
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Deleted User 11-Aug-22 02:31 PM
just make the brain go brr if u ask me
ultrabrain 1
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Netizenne
I think sirsad said psychedelics cause massive aberrant synaptogenesis like it was a bad thing, -but aren’t the abnormal/divergent connections of these substances where the creativity comes from???????
Odder_Sea (Glowie) 11-Aug-22 02:31 PM
Yeah, as long as you don't overdo it, and alternate with pruning protocols, I forsee mostly benefits
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Netizenne 11-Aug-22 02:32 PM
How do different dopamine receptors modulate aberrant synaptogenesis ? Could the novelty seeking of D2 and D4 be considered that?
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Odder_Sea (Glowie) 11-Aug-22 02:32 PM
Excited to find that Matrine may be a viable pruning aid, I'll pick some up in a few months with the ND winter sale
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Deleted User
just make the brain go brr if u ask me
Netizenne 11-Aug-22 02:32 PM
brrrrrrrrrrrrerrrrrrrraaaiiiiin
14:33
Ya I am not sure about pruning tbh
14:33
Is probably necessary but I think you’ve got a limited amount of connections to prune or something maybe (edited)
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Deleted User 11-Aug-22 02:33 PM
what I'm sure about psychs is that they produced a permanent hallucinatory state for me
14:33
I can't say it's bad tho
14:34
also I'm sure this state is largely underreported as many users don't even know what it is or that it came from psychs
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Netizenne
Is probably necessary but I think you’ve got a limited amount of connections to prune or something maybe (edited)
Odder_Sea (Glowie) 11-Aug-22 02:34 PM
Gets rid of the ones you don't need/reinforce. Can help with learning new habits/unlearning old habits Excessive use of neurogenics will probably lead to autism-like cognitive patterns over time
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Netizenne 11-Aug-22 02:35 PM
Image attachment
14:36
Image attachment
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Deleted User 11-Aug-22 02:36 PM
the problem with neurogenesis is that the neurons and synapses start stacking on top of one another
14:36
eventually u end up with a smooth brain
14:37
so the only way to really get gains is to trepanate and grow another brain outside
14:38
heh my pfp finally lived up to it's name
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Netizenne 11-Aug-22 02:38 PM
Disintegrins are what enable cancer cells to drill through tissues and invade/connect different regions I think. Maybe you can grow the brain without it all becoming connected somehow by researching these. (edited)
14:38
I could be wildly misrepresenting their role tho
14:38
Def double check that
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Deleted User 11-Aug-22 02:39 PM
today I had the weirdest trip
14:39
I stopped riding for a second
14:40
had the sensation of falling sideways
14:40
then extreme nausea and cold sweats for 20 mins
💀 1
😬 1
14:40
kinda like food poisoning
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Netizenne 11-Aug-22 02:41 PM
Hmmm that does not seem good lol
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Deleted User 11-Aug-22 02:41 PM
ye
14:41
weirdest thing is
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Netizenne 11-Aug-22 02:41 PM
It’ has been very hot out here lately
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Deleted User 11-Aug-22 02:42 PM
after the 20 mins like nothing happened
14:42
I can't handle the heat anymore for sure
14:42
it's fucking torture
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Netizenne
Click to see attachment 🖼️
Netizenne 11-Aug-22 03:19 PM
It is weird how this model almost suggests autism results from too much pruning tbh ……….
15:20
Like there’s something off there
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Netizenne
It is weird how this model almost suggests autism results from too much pruning tbh ……….
Netizenne 11-Aug-22 03:20 PM
@Yana
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Netizenne
It is weird how this model almost suggests autism results from too much pruning tbh ……….
Deleted User 11-Aug-22 03:24 PM
wth is that anyways
15:24
been staring at it for 2 mins straight
15:24
only to notice the title last
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Deleted User
wth is that anyways
Netizenne 11-Aug-22 03:35 PM
They use slime molds to model Tokyo subways system and now they’re using slime molds to mode human cognitive diversity
15:35
I guess
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Deleted User
it's fucking torture
Netizenne 11-Aug-22 03:38 PM
https://en.m.wikipedia.org/wiki/Siesta I am trying to learn how to siesta
Siesta
A siesta (from Spanish, pronounced [ˈsjesta] and meaning "nap") is a short nap taken in the early afternoon, often after the midday meal. Such a period of sleep is a common tradition in some countries, particularly those in warm-weather zones. The "siesta" can refer to the nap itself, or more generally to a period of the day, generally between 2...
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MEE6 BOT 11-Aug-22 03:38 PM
GG @Netizenne, you just advanced to level 3!
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Netizenne 11-Aug-22 03:39 PM
I’ve found I tend to have a midday period where I’ll laze in bed and kinda rest, but I don’t ever go so far as to actually sleep much
15:40
I just sit in bed all cozyyy
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Netizenne
https://en.m.wikipedia.org/wiki/Siesta I am trying to learn how to siesta
Deleted User 11-Aug-22 04:00 PM
that's easy for me
16:01
I just quit caffeine and modafinil
16:01
it's siesta all day every day
16:01
I have 20 mins of productivity
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Netizenne
https://en.m.wikipedia.org/wiki/Siesta I am trying to learn how to siesta
Yana 11-Aug-22 04:01 PM
https://supermemo.guru/wiki/Biphasic_life
Biphasic life
16:01
Image attachment
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Yana
Click to see attachment 🖼️
Deleted User 11-Aug-22 04:02 PM
now compare to modafinil graph
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Deleted User
now compare to modafinil graph
Yana 11-Aug-22 04:02 PM
Straighter
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Netizenne
@Yana
Yana 11-Aug-22 04:04 PM
idek
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Yana
Click to see attachment 🖼️
Netizenne 11-Aug-22 04:04 PM
That is a pretty good model of my day tbh
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Yana
Straighter
Deleted User 11-Aug-22 04:05 PM
the 2 PM drowsiness is hyperstimulation for me
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Deleted User
it's siesta all day every day
Netizenne 11-Aug-22 04:05 PM
Me too despair despair despair despair despair I must have chronic fatigue or something
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Yana 11-Aug-22 04:05 PM
This is why working until later in the day is crucial since you just get back home tired
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MEE6 BOT 11-Aug-22 04:05 PM
GG @Yana, you just advanced to level 1!
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Deleted User 11-Aug-22 04:05 PM
I need to get up and clean the apartment or do 150 pushups to feel normal again
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Yana 11-Aug-22 04:06 PM
The graph is hours after waking btw
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Yana
The graph is hours after waking btw
Deleted User 11-Aug-22 04:06 PM
the dip is around 2 PM
16:06
if u wake up at sunrise
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Yana 11-Aug-22 04:07 PM
Yeah
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Yana
Click to see attachment 🖼️
Netizenne 11-Aug-22 04:14 PM
If the Siesta is a summer phenomena, does that mean there’s less of a dip in this chart during the winter? Maybe melatonin or vitamin D control this. (edited)
16:15
What even is the biggest regulator of seasonal changes actually (edited)
16:19
Image attachment
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Netizenne
What even is the biggest regulator of seasonal changes actually (edited)
Deleted User 11-Aug-22 04:20 PM
serotonin
👀 1
16:21
serotonin production and release are dependent on retina light exposure
emoji_37 1
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Netizenne 11-Aug-22 04:21 PM
Waoh no way what the heck
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Netizenne
Waoh no way what the heck
Deleted User 11-Aug-22 04:22 PM
yeah it's pretty obvious even in everyday life
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Netizenne
Waoh no way what the heck
Deleted User 11-Aug-22 04:23 PM
btw did u see my write up
16:23
plenty of old ideas in a single article
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Deleted User
btw did u see my write up
Netizenne 11-Aug-22 04:24 PM
Where’s it at????? I need to lurk in rocket chat more
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Netizenne
Where’s it at????? I need to lurk in rocket chat more
Deleted User 11-Aug-22 04:24 PM
https://www.reddit.com/r/gvane/comments/wlo665/the_connection_between_occupational_reward/
r/gvane - The Connection Between Occupational Reward, Vesicular Neu...
1 vote and 0 comments so far on Reddit
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Netizenne 11-Aug-22 04:25 PM
Gvane Brain!!!!!! Waow
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Deleted User 11-Aug-22 04:25 PM
I need to up my writing game tho
16:26
so many redundant words
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Netizenne
https://en.m.wikipedia.org/wiki/Siesta I am trying to learn how to siesta
Potential 11-Aug-22 04:27 PM
Have you noticed that many people wake up with anxiety after an afternoon nap. 🤔
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Potential
Have you noticed that many people wake up with anxiety after an afternoon nap. 🤔
Deleted User 11-Aug-22 04:27 PM
it's a hit or miss for me
16:27
never anxiety
16:28
but sometimes it provides rest, sometimes it makes me even more tired
16:28
if I have nice dreams it's usually the most rejuvenating
16:28
lucid dreaming esp
16:29
I feel like the key is to stay conscious throughout the whole thing
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Deleted User
but sometimes it provides rest, sometimes it makes me even more tired
Potential 11-Aug-22 04:29 PM
You have to factor in the circadian rhythm. I've found with myself that a (max) 30min rest doesn't usually trigger anxiety.
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MEE6 BOT 11-Aug-22 04:29 PM
GG @Potential, you just advanced to level 2!
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Deleted User 11-Aug-22 04:29 PM
total loss of consciousness would be hard to get back from
This 1
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Potential 11-Aug-22 04:31 PM
A combination of L-theanine, Taurine and Phenibut is nice when I really need good quality sleep.
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Potential
You have to factor in the circadian rhythm. I've found with myself that a (max) 30min rest doesn't usually trigger anxiety.
Deleted User 11-Aug-22 04:31 PM
I don't think it's about duration at all. I could sit in meditation for 4 hours and not feel any more tired at all. But if I lose consciousness for more than a single REM cycle it's over
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Deleted User
https://www.reddit.com/r/gvane/comments/wlo665/the_connection_between_occupational_reward/
Netizenne 11-Aug-22 04:31 PM
I hope creatine helps my mitochondria 🤞
16:32
Day 2 today
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Netizenne
I hope creatine helps my mitochondria 🤞
Deleted User 11-Aug-22 04:32 PM
maybe slightly
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Netizenne
I hope creatine helps my mitochondria 🤞
Potential 11-Aug-22 04:32 PM
I'm potentially buying a photobiomodulation laser device soon and I'll update you on that. 👍
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Deleted User 11-Aug-22 04:32 PM
we'll see
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MEE6 BOT 11-Aug-22 04:33 PM
GG @Deleted User, you just advanced to level 8!
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Deleted User 11-Aug-22 04:33 PM
I need a way to quantify my experiments on this
16:33
but it's hard due to the fact that my training is inconsistent
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Netizenne
I hope creatine helps my mitochondria 🤞
Alyen 11-Aug-22 04:33 PM
I dont think theres any benefit to creatine if you eat enough beef
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Deleted User 11-Aug-22 04:34 PM
btw creatine HCL is a better idea IMO
16:34
if you're doing oral
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Alyen 11-Aug-22 04:35 PM
Why
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Netizenne
I hope creatine helps my mitochondria 🤞
Potential 11-Aug-22 04:35 PM
https://www.sciencedirect.com/science/article/pii/S0306452221006643 https://pubmed.ncbi.nlm.nih.gov/29307593/
Transcranial Photobiomodulation Therapy Ameliorates Perioperative N...
Perioperative neurocognitive disorder (PND) is a serious nervous system complication characterized by progressive cognitive impairment, especially in …
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Transcranial near-infrared photobiomodulation attenuates memory imp...
Sleep deprivation (SD) causes oxidative stress in the hippocampus and subsequent memory impairment. In this study, the effect of near-infrared (NIR) photobiomodulation (PBM) on learning and memory impairment induced by acute SD was investigated. The mice were subjected to an acute SD protocol for 72 …
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Potential
https://www.sciencedirect.com/science/article/pii/S0306452221006643 https://pubmed.ncbi.nlm.nih.gov/29307593/
Netizenne 11-Aug-22 04:37 PM
Oohhhhh How effective is it???????
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Deleted User 11-Aug-22 04:37 PM
thiamine is an idea u know @Netizenne
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Netizenne 11-Aug-22 04:38 PM
I suffer alotta sleep deprivation
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Netizenne
Oohhhhh How effective is it???????
Potential 11-Aug-22 04:38 PM
It's most likely very effective but we shall see.
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Deleted User 11-Aug-22 04:38 PM
like 1000 mg thiamine HCL and 100 mg benfo sulbu or alli thiamine
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Potential 11-Aug-22 04:38 PM
I will be conducting tests, as always.
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Deleted User 11-Aug-22 04:38 PM
and like emi said
16:38
snort the P5P
16:39
pyridoxine HCL should not be legal to sell
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Deleted User
thiamine is an idea u know @Netizenne
Odder_Sea (Glowie) 11-Aug-22 04:40 PM
Thiamine is clutch. Sulbutiamine (pure nootropics) TTFD/allithiamine and Benfotiamine are the bee's knees
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Deleted User 11-Aug-22 04:40 PM
issa secret unkind people will never uncover
16:41
because they're drenched in their pride and self assurance
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Deleted User
https://www.reddit.com/r/gvane/comments/wlo665/the_connection_between_occupational_reward/
Netizenne 11-Aug-22 04:42 PM
So simply increasing vmat is not good enough, I also need to improve mitochondria in order to provide them the energy to load the vesicles???? What is your treatment doc!!!!????????
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Netizenne
So simply increasing vmat is not good enough, I also need to improve mitochondria in order to provide them the energy to load the vesicles???? What is your treatment doc!!!!????????
Deleted User 11-Aug-22 04:42 PM
indeed
16:42
increasing VMAT2 without improving mitochondrial health concurrently will lead to random disorders
16:42
throw a dice
16:43
shizo
16:43
bipolar
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Odder_Sea (Glowie) 11-Aug-22 04:43 PM
Elliot Overton has me convinced that a cycle of high dose thiamine, say 500mg+ of the fat soluble forms, is useful for upregulating enzymes/cellular energy. If you make it a cycle of Sulbutiamine, you can increase D1 dopamine receptors tooemoji_49
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Odder_Sea (Glowie)
Elliot Overton has me convinced that a cycle of high dose thiamine, say 500mg+ of the fat soluble forms, is useful for upregulating enzymes/cellular energy. If you make it a cycle of Sulbutiamine, you can increase D1 dopamine receptors tooemoji_49
Deleted User 11-Aug-22 04:44 PM
u know
16:44
the body is not a fat blob
16:44
unless you're a fat blob
16:45
the brain does accept fat soluble subs via diffusion without transporter action
16:46
but the brain is not the only target of thiamine
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Deleted User
increasing VMAT2 without improving mitochondrial health concurrently will lead to random disorders
Odder_Sea (Glowie) 11-Aug-22 04:46 PM
IMO may, if not most, chronic diseases are to some degree mediated by impaired mitochondrial functioning
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Deleted User
the brain does accept fat soluble subs via diffusion without transporter action
Odder_Sea (Glowie) 11-Aug-22 04:47 PM
I'm on board with those points, bit I'm not tracking 100% what you are trying to communicate here
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Odder_Sea (Glowie)
IMO may, if not most, chronic diseases are to some degree mediated by impaired mitochondrial functioning
Deleted User 11-Aug-22 04:47 PM
indeed, as all transporters use cellular energy
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Deleted User
thiamine is an idea u know @Netizenne
Alyen 11-Aug-22 04:47 PM
Ttfd
16:48
Oh someone said that
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Odder_Sea (Glowie)
I'm on board with those points, bit I'm not tracking 100% what you are trying to communicate here
Deleted User 11-Aug-22 04:48 PM
just substantiating the stack. btw it's not my invention
16:48
the inventor is unknown
16:49
eventually I will develop a life-back serum without stims
16:50
just instant mitochondrial rockin and poppin
16:50
mitochondria go brrrr
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Netizenne 11-Aug-22 04:50 PM
sr9009 or PQQ for mitochondria health
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Netizenne
sr9009 or PQQ for mitochondria health
Deleted User 11-Aug-22 04:51 PM
both pls
16:51
I'm still hesistant about snorting PQQ
16:51
looks both appealing and dangerous at the same time
16:51
absolutely no info online
16:51
btw prob with sr9009 is the short half life
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Netizenne 11-Aug-22 04:52 PM
If I were to start with just 1, pqq is prob safer and more effective right?
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Deleted User 11-Aug-22 04:52 PM
u have to dose it every few hours
despair 1
16:52
at the very least
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Deleted User
u have to dose it every few hours
Netizenne 11-Aug-22 04:52 PM
Ouch what a pain
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Netizenne
If I were to start with just 1, pqq is prob safer and more effective right?
Deleted User 11-Aug-22 04:52 PM
yes
16:52
cheaper as well
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Deleted User
u have to dose it every few hours
Netizenne 11-Aug-22 04:53 PM
I think id probably use it more on a case by case basis in that case, just taking it when I wanna get stuff done
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Deleted User 11-Aug-22 04:53 PM
https://www.researchgate.net/publication/289577469_Positive_association_of_MAOA_and_VMAT2_with_autism_spectrum_disorder_ASD_in_the_indian_population
Positive association of MAOA and VMAT2 with autism spectrum disorde...
Request PDF | On Aug 1, 2015, B. Chakraborti and others published Positive association of MAOA and VMAT2 with autism spectrum disorder (ASD) in the indian population | Find, read and cite all the research you need on ResearchGate
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Netizenne
I think id probably use it more on a case by case basis in that case, just taking it when I wanna get stuff done
Deleted User 11-Aug-22 04:53 PM
not much acute effect by itself from what I've seen
16:54
never tried it
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Deleted User
https://www.researchgate.net/publication/289577469_Positive_association_of_MAOA_and_VMAT2_with_autism_spectrum_disorder_ASD_in_the_indian_population
Netizenne 11-Aug-22 04:55 PM
Any relevant genes you reccomend checking to see if I have?
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MEE6 BOT 11-Aug-22 04:55 PM
GG @Netizenne, you just advanced to level 4!
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Deleted User
never tried it
Netizenne 11-Aug-22 04:55 PM
Blanks been using it but idk if they knew to take it every few hours :/
16:56
Honestly I might not bother with it now that I know that
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Netizenne
Any relevant genes you reccomend checking to see if I have?
Deleted User 11-Aug-22 04:56 PM
well when it comes to this it's not gonna influence treatment anyways
16:56
I'm with Greger on that one
16:56
if you can spend money on something fun why spend it on a test
16:57
if the result is at least somewhat likely to affect your life choices sure take it
16:58
like if you were biten by a tick and your area has frequent lyme disease
16:58
test ASAP
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Deleted User
I'm still hesistant about snorting PQQ
Odder_Sea (Glowie) 11-Aug-22 04:59 PM
I'd move up to Skq1 before snorting PQQ tbh. I take PQQ in the AM with ALCAR
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MEE6 BOT 11-Aug-22 04:59 PM
GG @Odder_Sea (Glowie), you just advanced to level 2!
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Odder_Sea (Glowie)
I'd move up to Skq1 before snorting PQQ tbh. I take PQQ in the AM with ALCAR
Deleted User 11-Aug-22 04:59 PM
they don't do the same thing
17:00
PQQ is special there's no small molecule alike
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ibtisam.midlet 11-Aug-22 07:15 PM
Phenelizen will be bulletproof for neurotransmitters availability
19:16
Its very effective for social Anxiety
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Deleted User
they don't do the same thing
Odder_Sea (Glowie) 11-Aug-22 07:44 PM
What are your targets with IN PQQ?
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Deleted User
https://www.reddit.com/r/gvane/comments/wlo665/the_connection_between_occupational_reward/
komodo dragon 11-Aug-22 10:13 PM
Good post
22:13
Good read
22:13
👍
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Deleted User 11-Aug-22 11:17 PM
7/10 would boof again
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Odder_Sea (Glowie)
What are your targets with IN PQQ?
veganpermanently 12-Aug-22 12:12 AM
DJ-1. If u find another DA neuron penetrable compound that prevents DJ-1 oxidation you're golden. DJ-1 is a master regulator of VMAT2 expression. If the transporter is dysfunctional, oxidation rises and DJ-1 acts as a chemical antioxidant. The only way to stop the process is to introduce another antioxidant that is capable of DJ-1 protection which is only PQQ.
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Deleted User
serotonin production and release are dependent on retina light exposure
blank 12-Aug-22 12:12 AM
sometimes I feel a lot more productive if I just spend the whole day in the dark what does this mean 🧐
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veganpermanently
DJ-1. If u find another DA neuron penetrable compound that prevents DJ-1 oxidation you're golden. DJ-1 is a master regulator of VMAT2 expression. If the transporter is dysfunctional, oxidation rises and DJ-1 acts as a chemical antioxidant. The only way to stop the process is to introduce another antioxidant that is capable of DJ-1 protection which is only PQQ.
Odder_Sea (Glowie) 12-Aug-22 12:13 AM
Aha. I knew PQQ was OG. Suck it Sirsad
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veganpermanently 12-Aug-22 12:14 AM
BTW it's not like people have invented this. PQQ is endogenous and this is it's job in the brain
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veganpermanently
DJ-1. If u find another DA neuron penetrable compound that prevents DJ-1 oxidation you're golden. DJ-1 is a master regulator of VMAT2 expression. If the transporter is dysfunctional, oxidation rises and DJ-1 acts as a chemical antioxidant. The only way to stop the process is to introduce another antioxidant that is capable of DJ-1 protection which is only PQQ.
blank 12-Aug-22 12:14 AM
why hasn't anyone talked about this before 😩
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Odder_Sea (Glowie) 12-Aug-22 12:15 AM
How big of a difference are we going to see from IN administration versus oral? What's the Ideal dose for IN and Oral? I've been using 20mg in the AM with my ALCAR for synergistic effect and to prevent TMAO bacteria from colonizing. (edited)
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blank
sometimes I feel a lot more productive if I just spend the whole day in the dark what does this mean 🧐
veganpermanently 12-Aug-22 12:16 AM
Probably your 5ht2c is too sensitive to serotonin or you have too much oxidation, your kynurenine pathway is too activated. Dark metabolizes 5HT via AANAT preferentially.
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blank 12-Aug-22 12:16 AM
✍️
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blank
why hasn't anyone talked about this before 😩
veganpermanently 12-Aug-22 12:16 AM
Bcs I am the VMAT2 God
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Odder_Sea (Glowie)
How big of a difference are we going to see from IN administration versus oral? What's the Ideal dose for IN and Oral? I've been using 20mg in the AM with my ALCAR for synergistic effect and to prevent TMAO bacteria from colonizing. (edited)
veganpermanently 12-Aug-22 12:17 AM
I don't recommend IN no one has tried this before
00:17
There are no studies either. Unexpected results may occur esp in terms of nasal cavity
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veganpermanently
Bcs I am the VMAT2 God
Odder_Sea (Glowie) 12-Aug-22 12:18 AM
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veganpermanently
I don't recommend IN no one has tried this before
Odder_Sea (Glowie) 12-Aug-22 12:19 AM
Ok. Making sure I wasn't missing the boat on something awesome here. What do you feel is the ideal oral dose/schedule for general purposes?
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Odder_Sea (Glowie)
Ok. Making sure I wasn't missing the boat on something awesome here. What do you feel is the ideal oral dose/schedule for general purposes?
veganpermanently 12-Aug-22 12:19 AM
20 mg
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veganpermanently
20 mg
Odder_Sea (Glowie) 12-Aug-22 12:19 AM
Once daily?
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veganpermanently 12-Aug-22 12:23 AM
Yes
00:23
Morning
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Odder_Sea (Glowie) 12-Aug-22 12:23 AM
And what's your opinion on Ubiquinone/Ubiquinol? I've been taking them off and on for years, after learning that vegans tend to have lower levels. Currently on 100mg of vitacost ToCoQ10 with tocotrienols and bioperine in the AM, allegedly sun exposure converts it to ubiquinol in the bloodstream. Have some qunol ubiquinol I take on cloudy days
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veganpermanently 12-Aug-22 12:24 AM
I like it but it's too expensive. I'd like to do other things with my money now. Maybe when I'm older
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Odder_Sea (Glowie) 12-Aug-22 12:26 AM
And were you the one recommending chlorophyll? I picked up a bunch of chlorophyllin from LEF, allegedly activated by sunlight, some people theorize may assist with production of ATP, but haven't seen anything solid on it. I take 100mg with the ToCoQ10 in the AM (edited)
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CEO
Yo
blank 12-Aug-22 12:26 AM
emoji_51
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veganpermanently
I like it but it's too expensive. I'd like to do other things with my money now. Maybe when I'm older
Odder_Sea (Glowie) 12-Aug-22 12:26 AM
I picked up two years worth from vitacost for about $60 on sale
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Odder_Sea (Glowie)
And were you the one recommending chlorophyll? I picked up a bunch of chlorophyllin from LEF, allegedly activated by sunlight, some people theorize may assist with production of ATP, but haven't seen anything solid on it. I take 100mg with the ToCoQ10 in the AM (edited)
veganpermanently 12-Aug-22 12:28 AM
I recommend everyone to eat leaves (edited)
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MEE6 BOT 12-Aug-22 12:28 AM
GG @veganpermanently, you just advanced to level 3!
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veganpermanently 12-Aug-22 12:29 AM
Chlorophyll is one of the nice parts of leaf tho', holds a few biohacking secrets
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veganpermanently
I recommend everyone to eat leaves (edited)
Odder_Sea (Glowie) 12-Aug-22 12:30 AM
I eat tons of greens, But allegedly very little of intact chlorophyll makes it to the bloodstream
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Odder_Sea (Glowie)
I eat tons of greens, But allegedly very little of intact chlorophyll makes it to the bloodstream
veganpermanently 12-Aug-22 12:31 AM
Well the thing is chloroplasts have more than chlorophyll
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blank 12-Aug-22 12:32 AM
emoji_50
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veganpermanently 12-Aug-22 12:32 AM
I think juicing should release the contents
00:32
Wheat grass juice is nice if prepared fresh and well
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veganpermanently
I think juicing should release the contents
Odder_Sea (Glowie) 12-Aug-22 12:32 AM
I wonder if consuming with a bit of Sunflower lecithin may improve uptake?
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Odder_Sea (Glowie)
I wonder if consuming with a bit of Sunflower lecithin may improve uptake?
veganpermanently 12-Aug-22 12:34 AM
Cool idea. Without ultrasonication no but... When life gives you lemons Make a cake
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Odder_Sea (Glowie) 12-Aug-22 12:36 AM
I like to throw a teaspoon In with my green smoothies, I wondered if the vitamin released enough energy to liposomalize any fraction of the nutrients. I was under the impression the lipophyllic/emulsifying nature of lecithin would help with intestinal uptake even if not fully complexed,
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MEE6 BOT 12-Aug-22 12:36 AM
GG @Odder_Sea (Glowie), you just advanced to level 3!
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veganpermanently 12-Aug-22 12:36 AM
Time to start experimenting with this stuff. Liposomal everything, nano/microemulsions, etc.
00:38
Took 1500 mg MgCl yesterday before sleep. Bowel movement is now perfect
00:38
I Guess I was deficient
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Odder_Sea (Glowie) 12-Aug-22 12:39 AM
I've always wondered if you could make liposomal/PC DHA (Ala krill oil) with algae oil and lecithin via ultrasonic complexing, which may be beneficial for APOE carriers die to their poor transport of non-PC DHA across the BBB (edited)
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Odder_Sea (Glowie)
I've always wondered if you could make liposomal/PC DHA (Ala krill oil) with algae oil and lecithin via ultrasonic complexing, which may be beneficial for APOE carriers die to their poor transport of non-PC DHA across the BBB (edited)
veganpermanently 12-Aug-22 12:43 AM
PC no, liposomal yes but what this would do IDK
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veganpermanently
PC no, liposomal yes but what this would do IDK
Odder_Sea (Glowie) 12-Aug-22 12:44 AM
I think the AvailOM Algal should accomplish the same feat, so sort of a moot point maybe
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Odder_Sea (Glowie)
I think the AvailOM Algal should accomplish the same feat, so sort of a moot point maybe
veganpermanently 12-Aug-22 12:46 AM
ALA is superior anyways
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veganpermanently
ALA is superior anyways
Odder_Sea (Glowie) 12-Aug-22 12:54 AM
I know some if the literature suggests this, though I've always been concerned about relying on endogenous conversion for DHA, mostly from the positive studies of DHA intervention (though individuals were almost certainly not vegans) Related, I've seen it referenced that curcumin, and I think longvida specifically, may increased endogenous conversion of ALA into DHA in the brain
00:55
But also that the conversion is fairly oxidative in nature, so may result in excess ROS compared to exogenous, pre-formed DHA As in, 10 units of ALA have to be oxidized to get 1 unit of DHA. I'll try to find the source on that
00:56
For many years I was having several teaspoons per day of Flax/Chia, but slightly concerned about anti-androgenic effects of flax, as I'm (or was, last time I was checkedbtwo years ago) borderline low-T High-E
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Odder_Sea (Glowie)
But also that the conversion is fairly oxidative in nature, so may result in excess ROS compared to exogenous, pre-formed DHA As in, 10 units of ALA have to be oxidized to get 1 unit of DHA. I'll try to find the source on that
Deleted User 12-Aug-22 12:58 AM
it doesn't matter. the compounds themselves are antioxidants so this reaction is actually protecting everything else from oxidation. It's like saying don't take PQQ because it oxidizes. Of course it does - it's an antioxidant
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Odder_Sea (Glowie)
For many years I was having several teaspoons per day of Flax/Chia, but slightly concerned about anti-androgenic effects of flax, as I'm (or was, last time I was checkedbtwo years ago) borderline low-T High-E
Deleted User 12-Aug-22 12:59 AM
dietary phytoestrogens will not influence endogenous hormone levels. If anything they should reduce estrogen, but they don't
01:01
but. it's probably best to get an oil press and press your own oil from flax, not for the phytoestrogens but the cyanogenic glycosides. A few teaspoons will not be toxic but if you want real gains from ALA you need to press it
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Deleted User
dietary phytoestrogens will not influence endogenous hormone levels. If anything they should reduce estrogen, but they don't
Odder_Sea (Glowie) 12-Aug-22 01:02 AM
I don't believe that Flax's anti-androgenic effects were mediated primarily by phytoestrogen. I consider phytoestrogens to be generally positive for men and women
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Deleted User 12-Aug-22 01:02 AM
why not just buy flax oil? it oxidizes quickly when it's not protected by the seed shell. You need to consume it within 4 hours of pressing. Which is why homepress is best. It's also the cheapest, tho' the upfront cost is about 300 USD.
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Deleted User
why not just buy flax oil? it oxidizes quickly when it's not protected by the seed shell. You need to consume it within 4 hours of pressing. Which is why homepress is best. It's also the cheapest, tho' the upfront cost is about 300 USD.
Odder_Sea (Glowie) 12-Aug-22 01:03 AM
I normally just used flax ground at home In a coffee grinder- the ALA is stable for over 6months at room temperature, which was irrelevant as I'd keep it in the fridge in a Mason jar and make a new batch every few weeks
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Odder_Sea (Glowie)
I normally just used flax ground at home In a coffee grinder- the ALA is stable for over 6months at room temperature, which was irrelevant as I'd keep it in the fridge in a Mason jar and make a new batch every few weeks
Deleted User 12-Aug-22 01:05 AM
yes even when ground it is stable because the shell contains antioxidants, but when you separate the oil it oxidizes within hours
01:06
@Netizenne yo this is what I was talking about the other day
01:06
why do people DM me with small talk
01:06
do I appear like such a person
01:07
'hey dude' 'what's good bruh'
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Deleted User
yes even when ground it is stable because the shell contains antioxidants, but when you separate the oil it oxidizes within hours
Odder_Sea (Glowie) 12-Aug-22 01:08 AM
Yeah, and all the fiber benefits/blood sugar mitigating effects are from the ground seeds, not the oil
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Deleted User
'hey dude' 'what's good bruh'
blank 12-Aug-22 01:08 AM
I feel like those are spam accounts
01:09
I've actually tried to talk to them a few times and they are unable to do so and just keep repeating small talk phrases
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Odder_Sea (Glowie) 12-Aug-22 01:09 AM
Imma start doing that again, Aldi's sells the seeds for dirt cheap. Adding a tablespoon to every meal/smoothie
01:09
Really good for giving a smoothie a thick. Ice-creamy texture
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blank
I've actually tried to talk to them a few times and they are unable to do so and just keep repeating small talk phrases
Deleted User 12-Aug-22 01:09 AM
I don't even know what to respond in the case it's a real person
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blank 12-Aug-22 01:10 AM
ask them if they have done anything interesting recently
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MEE6 BOT 12-Aug-22 01:10 AM
GG @blank, you just advanced to level 2!
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blank 12-Aug-22 01:10 AM
usually shuts them up 😂
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blank
ask them if they have done anything interesting recently
Deleted User 12-Aug-22 01:10 AM
I asked if it was a bot
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Odder_Sea (Glowie)
Really good for giving a smoothie a thick. Ice-creamy texture
Deleted User 12-Aug-22 01:11 AM
yes I prepare a smoothie like this every day: 200 g Banana 200 mL Soy milk 20 g Flax seed 30 g Chia seed 3 g Ceylon Cinnamon Water until consistency is desireable
01:12
I omit the ceylon and soy milk while fasting mimicking and use just 1 banana. less seeds as well
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Deleted User
yes I prepare a smoothie like this every day: 200 g Banana 200 mL Soy milk 20 g Flax seed 30 g Chia seed 3 g Ceylon Cinnamon Water until consistency is desireable
Odder_Sea (Glowie) 12-Aug-22 01:13 AM
Do you pre-grind the flax?
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blank
ask them if they have done anything interesting recently
Deleted User 12-Aug-22 01:14 AM
he said he's not a bot, he comes in peace and proceeded with the small talk
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Deleted User
he said he's not a bot, he comes in peace and proceeded with the small talk
Odder_Sea (Glowie) 12-Aug-22 01:14 AM
Kill it with fire
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Odder_Sea (Glowie)
Do you pre-grind the flax?
Deleted User 12-Aug-22 01:14 AM
yes in a coffee grinder
01:15
I love it how my reddit karma keeps going up and down
01:15
all posts have below 70% upvote rate
01:15
emoji_51
01:17
https://www.reddit.com/r/fuckcars/comments/wlrjgz/for_a_while_i_have_been_video_recording_when/
r/fuckcars - for a while I have been video recording when crossing ...
25,306 votes and 1,340 comments so far on Reddit
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11-Aug-22 06:34 AM
01:17
everyday life in croatia be like
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Deleted User
https://www.reddit.com/r/fuckcars/comments/wlrjgz/for_a_while_i_have_been_video_recording_when/
Odder_Sea (Glowie) 12-Aug-22 01:20 AM
I just saw that posted on r/idiotsincars
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blank 12-Aug-22 01:20 AM
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01:20
that would never happen here
01:21
it's more an issue that cars stop for you even when they wouldn't have needed to and you awkwardly walk in front of them while they are stopped 😂 (edited)
01:22
but I'm glad it be this way
01:23
like here the second car already would have stopped and maybe even the first car on a weird day
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blank
it's more an issue that cars stop for you even when they wouldn't have needed to and you awkwardly walk in front of them while they are stopped 😂 (edited)
Deleted User 12-Aug-22 01:25 AM
there's a law here that states a cyclist needs to get off the bike when crossing a zebra. but cyclists are not allowed to ride on the pedestrian pavement. so you know how fucked up it is
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blank
it's more an issue that cars stop for you even when they wouldn't have needed to and you awkwardly walk in front of them while they are stopped 😂 (edited)
Netizenne 12-Aug-22 01:25 AM
Lol same Sometimes I’ll wait to J-walk and the car will stop even though there’s no intersections or crosswalks lmfao So instead I just have to really slowly walk or pose like I’m not waiting on traffic to cross xdddd
💯 1
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Deleted User 12-Aug-22 01:25 AM
there is an obvious contradiction in law
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Netizenne 12-Aug-22 01:26 AM
I always get mad inside “like wtf!!! You have the right of what wtf are you doing!!!?!???”
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Netizenne
Lol same Sometimes I’ll wait to J-walk and the car will stop even though there’s no intersections or crosswalks lmfao So instead I just have to really slowly walk or pose like I’m not waiting on traffic to cross xdddd
Deleted User 12-Aug-22 01:26 AM
it's like you're living in a GTA city
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Deleted User
it's like you're living in a GTA city
Netizenne 12-Aug-22 01:26 AM
Ya lmao ig
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Deleted User 12-Aug-22 01:27 AM
usually the traffic is fine here but not because of law
01:27
but because the people have unwritten rules they stand by
01:27
mostly respect and logic
01:27
but one fool is enough to throw my mood off for the whole day
01:28
it's mostly Bosnians roflmao
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Deleted User
usually the traffic is fine here but not because of law
Odder_Sea (Glowie) 12-Aug-22 01:28 AM
Are you also Croat?
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Odder_Sea (Glowie)
Are you also Croat?
Deleted User 12-Aug-22 01:28 AM
yes
01:28
I am VP dude
Awwwhhh 1
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Deleted User
it's mostly Bosnians roflmao
Deleted User 12-Aug-22 01:29 AM
with a heavy accent and no common sense
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Netizenne 12-Aug-22 01:30 AM
okaye gn
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Deleted User 12-Aug-22 01:31 AM
I need to up my glycogen game
01:31
thinking D Ribose high dose
01:33
isomaltulose as well
01:34
pea protein
01:37
https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/oral-hydroxycitrate-supplementation-enhances-glycogen-synthesis-in-exercised-human-skeletal-muscle/D77A9A80E6DAC87EA8FE1EE819129F6B
Oral hydroxycitrate supplementation enhances glycogen synthesis in ...
Oral hydroxycitrate supplementation enhances glycogen synthesis in exercised human skeletal muscle - Volume 107 Issue 7
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01:37
if someone has more ideas lemme kno
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Deleted User
I am VP dude
Odder_Sea (Glowie) 12-Aug-22 01:37 AM
How many alts you got bruh
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Potential 12-Aug-22 01:37 AM
@Deleted User It seems that we are neighbours. I find the interactions between former nations of Yugoslavia intriguing to say the least. So much pride everywhere.
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Odder_Sea (Glowie) 12-Aug-22 01:38 AM
Is this a whole server of VP arguing with himself with different avatars?
😂 1
REAL 1
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Deleted User 12-Aug-22 01:38 AM
😂
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Odder_Sea (Glowie) 12-Aug-22 01:40 AM
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Potential
@Deleted User It seems that we are neighbours. I find the interactions between former nations of Yugoslavia intriguing to say the least. So much pride everywhere.
Deleted User 12-Aug-22 01:41 AM
I don't have pride about my people, I feel pity if anything. I feel we suffered greatly historically. All of the nations here. Our true cultural identities are stolen. I have pride about where we all come from, pride about this geographical space, it's very special
01:43
what I said about Bosnians and road, they don't understand things in Zagreb don't work according to law. Common sense needs to be applied for everything to work smoothly
01:43
if they spend some time here eventually they realize how things work
01:44
it's not about them, it's about the cultural shock. all minorities are like this it's just that the Bosnians are the most frequent minority
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Odder_Sea (Glowie) 12-Aug-22 01:48 AM
https://www.leoandlongevity.com/post/changing-2-of-your-genes-with-sodium-butyrate-my-second-favorite-salt
Changing 2% of Your Genes with Sodium Butyrate: My Second Favorite ...
A bird's eye summary of the research on sodium butyrate's effects on health.
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01:48
What ya think VP?
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Odder_Sea (Glowie)
https://www.leoandlongevity.com/post/changing-2-of-your-genes-with-sodium-butyrate-my-second-favorite-salt
Deleted User 12-Aug-22 01:48 AM
I found some issue about butyrate supplementation one night when I was overly stoned but forgot about what it was
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MEE6 BOT 12-Aug-22 01:48 AM
GG @Deleted User, you just advanced to level 9!
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Deleted User
I found some issue about butyrate supplementation one night when I was overly stoned but forgot about what it was
Odder_Sea (Glowie) 12-Aug-22 01:49 AM
I'm interested in butylated hydroxytoluene. Any thought on that?
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MEE6 BOT 12-Aug-22 01:49 AM
GG @Odder_Sea (Glowie), you just advanced to level 4!
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Deleted User 12-Aug-22 01:57 AM
https://www.dm.hr/frutabela-nature-vocna-plocica-malina-i-cikla-p3838945030847.html
01:57
order 100 of these you won't regret
01:58
nootropic ergogenic tastes like Eden
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Odder_Sea (Glowie)
I'm interested in butylated hydroxytoluene. Any thought on that?
Deleted User 12-Aug-22 01:59 AM
https://www.biorxiv.org/content/10.1101/2020.02.04.934919v1.full
Short chain fatty acid butyrate promotes virus infection by repress...
Butyrate is an abundant metabolite produced by the gut microbiota and is known to modulate multiple immune system pathways and inflammatory diseases. However, studies of its effects on virus infection of cells are limited and enigmatic. We found that butyrate increases cellular infection and virus replication in influenza virus, reovirus, and hu...
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02:00
something to be considered regarding all dietary interventions
02:03
https://watermark.silverchair.com/cr0470164407.pdf
02:03
yes I found it
02:03
Butyrates will cause Epstein Barr reinfection @Odder_Sea (Glowie) be careful
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Deleted User
https://www.biorxiv.org/content/10.1101/2020.02.04.934919v1.full
Odder_Sea (Glowie) 12-Aug-22 02:05 AM
Interesting. I was peaked in interest on BHT as it is alleged to supress herpes viruses, and I am swayed by the viral theory of alzheimers (though as a degenerative symptom, rather than the root cause)
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Odder_Sea (Glowie)
Interesting. I was peaked in interest on BHT as it is alleged to supress herpes viruses, and I am swayed by the viral theory of alzheimers (though as a degenerative symptom, rather than the root cause)
Deleted User 12-Aug-22 02:05 AM
https://pubmed.ncbi.nlm.nih.gov/26205347/
Inhibition of class I histone deacetylases by romidepsin potently i...
Pan-histone deacetylase (HDAC) inhibitors, which inhibit 11 HDAC isoforms, are widely used to induce Epstein-Barr virus (EBV) lytic cycle in EBV-associated cancers in vitro and in clinical trials. Here, we hypothesized that inhibition of one or several specific HDAC isoforms by selective HDAC inhibi …
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02:05
the most interesting thing you can use it to chase out the virus and kill it
02:08
I feel like everything I take is making my face look younger by the day but I still have acne problems due to excessive sebum secretion
02:09
does anybody have biohacks against this other than the retinoids
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Deleted User
the most interesting thing you can use it to chase out the virus and kill it
Odder_Sea (Glowie) 12-Aug-22 02:09 AM
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Deleted User
I feel like everything I take is making my face look younger by the day but I still have acne problems due to excessive sebum secretion
Odder_Sea (Glowie) 12-Aug-22 02:11 AM
Ditching most processed oils from my diet gives me zero facial acne and great skin
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Odder_Sea (Glowie)
Ditching most processed oils from my diet gives me zero facial acne and great skin
Deleted User 12-Aug-22 02:11 AM
IG I could try that. I still use olive oil and pumpkin seed oil
02:11
makes the dishes way better
02:12
the prob is I've inherited this sebum secretory skin from my mother
02:12
she still has acne sometimes at nearly 60 yrs old
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Odder_Sea (Glowie) 12-Aug-22 02:13 AM
I only use a dash of olive oil (Sirtuin activator) and a few caps of NCT with my morning coffee/tea, and some algae oil at night. Other than that, it's Carbs carbs, carbs
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Odder_Sea (Glowie)
I only use a dash of olive oil (Sirtuin activator) and a few caps of NCT with my morning coffee/tea, and some algae oil at night. Other than that, it's Carbs carbs, carbs
Deleted User 12-Aug-22 02:13 AM
I think it's key to separate the oils from the carbs
02:14
I notice instant sebum secretion when I consume a meal that's high in both
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Deleted User
I think it's key to separate the oils from the carbs
Odder_Sea (Glowie) 12-Aug-22 02:14 AM
Def don't play well together. I love Olive oil, there's a great Grove nearby I need to check out. But at the end of the day, it's just fat emoji_52
02:15
I'm trying to maximize insulin sensitivity and cut bodyfat
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Deleted User 12-Aug-22 02:15 AM
indeed. omega 9 increases sebum secretion
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Odder_Sea (Glowie)
I'm trying to maximize insulin sensitivity and cut bodyfat
Deleted User 12-Aug-22 02:15 AM
use my protocol
02:15
you will cut within days
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Deleted User
use my protocol
Odder_Sea (Glowie) 12-Aug-22 02:15 AM
What's your prootocol
02:15
Bro
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Odder_Sea (Glowie)
What's your prootocol
Deleted User 12-Aug-22 02:15 AM
u don't know
02:15
omg
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Odder_Sea (Glowie) 12-Aug-22 02:16 AM
IDK sheet
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Deleted User 12-Aug-22 02:16 AM
there's a lot to be said
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Odder_Sea (Glowie) 12-Aug-22 02:16 AM
Lay it on me you Croatian MF'er
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Deleted User 12-Aug-22 02:17 AM
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02:17
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02:17
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02:18
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02:19
I modified it. omitted the memantine and DHF for optimal neuronal pruning
02:20
1st day 1200 kcal 40 g protein 2nd-5th day 725 kcal and 30 g protein
02:20
light endurance exercise as much as possible, without strenous activity
02:21
when you refeed don't introduce food in 500 kcal increments per day. do not bring in more at once it will cause hyperglycemia. space out the meals as much as possible in the insulin sensitive window
02:22
which is 9 AM to 2 PM and 3PM to 6 PM
02:23
subL matcha is essential for optimal visceral fat targeted weight loss. also improves fasting tolerance i.e. reduces hunger
02:24
will make you a bit nauseous if you do it food a few hours after you take it tho
02:24
so do it first thing in the morning and around 1 o clock PM (edited)
02:25
the original protocol is by Valter Longo I have only build upon it
02:26
https://www.youtube.com/watch?v=d6PyyatqJSE
FoundMyFitness
Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevi...
02:26
he is a true genius no other doctor like him on the planet
02:27
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02:28
will play more with the protocol, I think B vitamins may be key here.
02:30
btw the addition of Rapamycin may have caused too much autophagy and apoptosis. I had a headache and muscle pains on day 3 last time I did it. Stimulation followed by weakness, had to take a nap
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Deleted User
subL matcha is essential for optimal visceral fat targeted weight loss. also improves fasting tolerance i.e. reduces hunger
Odder_Sea (Glowie) 12-Aug-22 02:30 AM
Would EGCG or Green Tea phytosome have the same effect?
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Odder_Sea (Glowie)
Would EGCG or Green Tea phytosome have the same effect?
Deleted User 12-Aug-22 02:31 AM
likely yes, but only with caffeine
02:31
caffeine + EGCG have synergistic anorectic effects
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Odder_Sea (Glowie) 12-Aug-22 02:32 AM
I usually take with caffeine, such as organic coffee, Fresh green yerba mate, and or guayusa (edited)
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Deleted User 12-Aug-22 02:32 AM
nice
02:32
btw don't do this too often. it will be stressful on the psyche first time you do it
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Odder_Sea (Glowie) 12-Aug-22 02:33 AM
I have a bunch of the green-tea phytomse from science.bio shutdown. I have a bag of Jade leaf matcha, but I try to limit my green tea intake due to flouride concerns (edited)
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Deleted User 12-Aug-22 02:33 AM
body and brain literally sense famine incoming
02:33
which is exactly the point of this
02:33
to signal repair and optimization
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Odder_Sea (Glowie) 12-Aug-22 02:34 AM
I've been doing calorie restriction/IF vegan for years
02:34
Its been a while since I've done a proper 72hr plus fast
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Deleted User 12-Aug-22 02:34 AM
yeah calorie restriction is not as effective in my and Longo's opinion
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Odder_Sea (Glowie)
Its been a while since I've done a proper 72hr plus fast
Deleted User 12-Aug-22 02:34 AM
takes 3 days to enter true autophagy.
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Odder_Sea (Glowie) 12-Aug-22 02:35 AM
I think protein, or more specifically Leucine/methionine restriction is generally superior
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Deleted User 12-Aug-22 02:35 AM
I don't recommend true fasting because it can cause electrolyte imbalances and hypoglycemia followed by the extreme hyperglycemic state when refed
02:36
this can be life threatening
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Deleted User
I don't recommend true fasting because it can cause electrolyte imbalances and hypoglycemia followed by the extreme hyperglycemic state when refed
Odder_Sea (Glowie) 12-Aug-22 02:36 AM
I'd like to try for 5 days with NAD+ and senolytics at some point
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Deleted User 12-Aug-22 02:36 AM
your vitals need to be monitored
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Odder_Sea (Glowie) 12-Aug-22 02:36 AM
Might be a good time to reset my caffeine tilerance
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Odder_Sea (Glowie)
I'd like to try for 5 days with NAD+ and senolytics at some point
Deleted User 12-Aug-22 02:36 AM
just try the FMD you will be convinced the benefits are the same, yet the risks are greatly diminished
02:37
there is no reasoning to do a true fast after Longo's work
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Deleted User
Click to see attachment 🖼️
Odder_Sea (Glowie) 12-Aug-22 02:37 AM
You did show me this one before, the FMD cronometer
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Deleted User 12-Aug-22 02:37 AM
it should be a thing of the past now
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Deleted User
light endurance exercise as much as possible, without strenous activity
Odder_Sea (Glowie) 12-Aug-22 02:38 AM
Would multiple hour walks suffice for this?
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Deleted User 12-Aug-22 02:38 AM
I don't think humans have ever historically fasted at all, there was always some food to it, but it was limited at times
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Odder_Sea (Glowie)
Would multiple hour walks suffice for this?
Deleted User 12-Aug-22 02:38 AM
indeed
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Deleted User
indeed
Odder_Sea (Glowie) 12-Aug-22 02:38 AM
That's my antidepressant of choice
02:39
I hadn't watched Longo interview or reviewed much of his literature
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Odder_Sea (Glowie)
That's my antidepressant of choice
Deleted User 12-Aug-22 02:39 AM
mine is cycling. my walking parts of the brain have withered away. I even cringe a little when I see people walk roflmao
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Deleted User
mine is cycling. my walking parts of the brain have withered away. I even cringe a little when I see people walk roflmao
Odder_Sea (Glowie) 12-Aug-22 02:40 AM
Randomly went on a 6 hour walk the other day
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Deleted User 12-Aug-22 02:40 AM
sometimes I choose to walk to the store
02:40
feels extremely awkward
02:41
like I'm a demon that just took control of a new host
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Deleted User
like I'm a demon that just took control of a new host
Odder_Sea (Glowie) 12-Aug-22 02:44 AM
Your alts are starting to make more sense
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Deleted User 12-Aug-22 02:46 AM
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02:46
he's not wrong
02:46
but his solution is
02:46
people need to ride bikes
02:47
quite simply. laziness needs to be nooked with chemicals
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Deleted User
Click to see attachment 🖼️
Odder_Sea (Glowie) 12-Aug-22 02:51 AM
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Odder_Sea (Glowie)
Click to see attachment 🖼️
Deleted User 12-Aug-22 02:54 AM
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02:54
Amsterdam everywhere please
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Odder_Sea (Glowie) 12-Aug-22 02:56 AM
The Segway guy was onto something IMO
02:56
Bike speeds in a walking footprint
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Odder_Sea (Glowie)
Bike speeds in a walking footprint
Deleted User 12-Aug-22 02:56 AM
wut
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Deleted User
wut
Odder_Sea (Glowie) 12-Aug-22 02:57 AM
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MEE6 BOT 12-Aug-22 02:57 AM
GG @Odder_Sea (Glowie), you just advanced to level 5!
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Odder_Sea (Glowie) 12-Aug-22 02:58 AM
Great solution for urban mobility, of there was sufficient adoption/infrastructure created with them in mind. However due to the cost and stigma, they remain niche
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Odder_Sea (Glowie)
Click to see attachment 🖼️
Deleted User 12-Aug-22 02:58 AM
ye I know what a segway is. it's less safe compared to a non-electric bike, has a way higher footprint, burns almost no calories at all
02:58
also you look like a dork
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Deleted User
ye I know what a segway is. it's less safe compared to a non-electric bike, has a way higher footprint, burns almost no calories at all
Odder_Sea (Glowie) 12-Aug-22 02:58 AM
Wdym by footprint?
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Deleted User
also you look like a dork
Odder_Sea (Glowie) 12-Aug-22 02:59 AM
That's the stigma
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Odder_Sea (Glowie)
Wdym by footprint?
Deleted User 12-Aug-22 02:59 AM
ecological footprint. it still uses lithium batteries, requires a computer, etc.
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Deleted User
people need to ride bikes
blank 12-Aug-22 02:59 AM
And cities need to have everything necessary in a few km range
03:00
https://twitter.com/wrathofgnon
03:00
🙏
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Deleted User 12-Aug-22 03:00 AM
average lifetime of Segway and electric scooters is abysmal compared to a bicycle. esp if it steel or aluminum
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Deleted User
ecological footprint. it still uses lithium batteries, requires a computer, etc.
Odder_Sea (Glowie) 12-Aug-22 03:00 AM
Yup
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Deleted User 12-Aug-22 03:01 AM
I have an aluminum frame now. as soon as I kill it somehow I'm getting a stainless steel bike and keeping it for life
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blank
And cities need to have everything necessary in a few km range
Deleted User 12-Aug-22 03:02 AM
not really people just need to become stamina beasts they really are again
03:02
takes me 30 mins to cross 10 km easily.
03:03
we are made for bicycles. feet are fucked up. but legs are optimal
03:03
hence we can barely run without getting injured
03:04
but anyone can ride a bike as long as their mitochondrion are functional (edited)
03:04
and the best thing is, riding a bike makes the mitochondrion functional
emoji_49 1
03:04
so it's a self fulfilling prophecy in a way
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Odder_Sea (Glowie) 12-Aug-22 03:05 AM
I've had an aluminum felt for years. Done many a repairs to keep it chugging. It's a mountain bike frame that I put road tires on, and allows me to lock out the front shocks on road, and I can swap in my offroad tires if I want to hit trails (edited)
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Deleted User 12-Aug-22 03:06 AM
blank I read your stylized username like a retarded brit would pronounce the word blunt while spitting saliva in your face
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Odder_Sea (Glowie) 12-Aug-22 03:06 AM
Sadly I trashed my knee years ago from commuting by bike too much, I think I have a cyst on my left IT band and wayy advanced arthritis for my age
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Deleted User
blank I read your stylized username like a retarded brit would pronounce the word blunt while spitting saliva in your face
blank 12-Aug-22 03:06 AM
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Odder_Sea (Glowie)
Sadly I trashed my knee years ago from commuting by bike too much, I think I have a cyst on my left IT band and wayy advanced arthritis for my age
Deleted User 12-Aug-22 03:07 AM
IDK what's your exact problem with the knees but biking did not cause it
03:07
if you push too hard you can fuck up your knees
03:08
if you do drops you will fuck up your knees
03:08
if your bike is too small you will fuck up your knees
03:08
if your pedals are too close together for your hip size it will fuck up your knees
03:09
if you know how to ride and did a proper bike fit, you will not fuck up your knees
03:09
in fact it will heal your knees
03:09
I had many knee accidents in my life and biking has always improved it and got me back on track
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Deleted User
IDK what's your exact problem with the knees but biking did not cause it
Odder_Sea (Glowie) 12-Aug-22 03:10 AM
I was commuting 15 miles per day for years along with recreation riding. I left work and was pedaling hard and felt a pop, never been the same since. Had a bunch of MRI's and x-rays, orthopedic surgeons Saud there wasn't much they could do
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Deleted User 12-Aug-22 03:10 AM
yeah you got humbled I guess
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Odder_Sea (Glowie) 12-Aug-22 03:10 AM
Told me I'll need a knee replacement, eventually diuble
03:10
However
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Deleted User 12-Aug-22 03:10 AM
I ride at high speeds but never push
03:11
build up the speed slowly
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Odder_Sea (Glowie) 12-Aug-22 03:11 AM
I yhink I'll try to Find a doc whose willing to do arthroscopy
03:11
And then start on Stem cells and rehab
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Deleted User 12-Aug-22 03:12 AM
have u trialed bpc
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Odder_Sea (Glowie) 12-Aug-22 03:12 AM
I don't want bionic parts. I wanna fix my OEM
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Deleted User
have u trialed bpc
Odder_Sea (Glowie) 12-Aug-22 03:12 AM
I have two Nasal sprays from science.bio, considered injecting
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Deleted User 12-Aug-22 03:12 AM
nasal spray delivery is often suboptimal
03:13
injecting is best
03:13
but be careful. talk to Cogmetics. he has some things against it
03:13
I never had the need to do it so never really researched it well
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Odder_Sea (Glowie)
I don't want bionic parts. I wanna fix my OEM
blank 12-Aug-22 03:15 AM
bionic legs though 🤤
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Deleted User 12-Aug-22 03:15 AM
btw I slept like a baby. had a dream in which a random person I know tried to mog me for money with some gang members. I tricked them with word play they left
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blank 12-Aug-22 03:15 AM
🤣
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Deleted User
btw I slept like a baby. had a dream in which a random person I know tried to mog me for money with some gang members. I tricked them with word play they left
Odder_Sea (Glowie) 12-Aug-22 03:15 AM
Busting rhymes on these ninjas
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Odder_Sea (Glowie)
Busting rhymes on these ninjas
Deleted User 12-Aug-22 03:16 AM
Monkey Island vibes
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Deleted User
but be careful. talk to Cogmetics. he has some things against it
Odder_Sea (Glowie) 12-Aug-22 03:16 AM
Uxkull got depressive symptoms IIRC
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Odder_Sea (Glowie)
Uxkull got depressive symptoms IIRC
Deleted User 12-Aug-22 03:19 AM
well not a very trustworthy source on anecdotals kek
03:19
but there's more. Cog knows more
03:21
@ibtisam.midlet would u like to introduce this emoji. I can edit it for the transparent bg
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MEE6 BOT 12-Aug-22 03:21 AM
GG @Deleted User, you just advanced to level 10!
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Deleted User 12-Aug-22 03:23 AM
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03:23
fuck I need this sticker on my bike
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Deleted User 12-Aug-22 04:01 AM
https://link.springer.com/article/10.1007/s11011-021-00836-y
Oxytocin levels in individuals with schizophrenia are high in cereb...
Metabolic Brain Disease - Schizophrenia is a debilitating mental illness. Levels of oxytocin have been proposed as a biomarker of schizophrenia; however, the observed levels of oxytocin in...
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blank 12-Aug-22 04:12 AM
suspicious
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blank
suspicious
Deleted User 12-Aug-22 04:13 AM
u have too much oxytocin bruh
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Deleted User
u have too much oxytocin bruh
blank 12-Aug-22 04:14 AM
I used to be really autistic though
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ibtisam.midlet 12-Aug-22 04:14 AM
@Deleted User there is no place, do you have GIF emojis?
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blank 12-Aug-22 04:14 AM
emoji_49
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Deleted User 12-Aug-22 04:14 AM
it really explains a lot about shizotypal minds considering the effects of oxytocin on outgroup aggression
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blank 12-Aug-22 04:14 AM
this emoji is duplicated
04:15
and discord has it's own flag emojis so they could just be removed
04:15
🔪
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blank
emoji_49
ibtisam.midlet 12-Aug-22 04:15 AM
I forget to stole this
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blank 12-Aug-22 04:15 AM
emoji_21 🔥
04:15
2 different fire emojis too 😩
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Deleted User 12-Aug-22 04:15 AM
Pepe is the best
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blank
and discord has it's own flag emojis so they could just be removed
ibtisam.midlet 12-Aug-22 04:15 AM
That's Unicode 9.0 before google start getting crazy
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Deleted User 12-Aug-22 04:15 AM
toad men mascot
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ibtisam.midlet 12-Aug-22 04:16 AM
They just seek novelty
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Deleted User 12-Aug-22 04:16 AM
I wanted Murray to mock annoying users
04:18
Image attachment
04:18
this one is better for that purpose
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ibtisam.midlet 12-Aug-22 04:18 AM
emoji_51 emoji_40 emoji_40
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Deleted User 12-Aug-22 04:19 AM
https://monkeyisland.fandom.com/wiki/Murray
Murray
"... and the forces of darkness will applaud me as I STRIDE through the gates of hell carrying your head on a pike!" ―Murray Murray is a Demonic Skull that terrorized Guybrush Threepwood who first appeared the Curse of Monkey Island. He was originally part of LeChuck's Army of the Undead, before losing his entire skeletal body, and becoming some...
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blank 12-Aug-22 04:19 AM
emoji_51
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MEE6 BOT 12-Aug-22 04:19 AM
GG @blank, you just advanced to level 3!
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Deleted User 12-Aug-22 04:19 AM
if the user knows the context it's even more effective
04:21
https://www.reddit.com/r/Nootropics/comments/wmbpv1/why_alphagpc_and_cdpcholine_can_temporarily_cause/
r/Nootropics - Why alpha-GPC and CDP-choline can temporarily cause ...
6 votes and 4 comments so far on Reddit
04:21
finally some contribution from r/Nootropics
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Deleted User 12-Aug-22 04:28 AM
btw dudes and dudettes. if anyone has COVID anosmia let me know
04:28
I managed to fully recover from mine
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Deleted User 12-Aug-22 04:41 AM
I am still mesmerized by the fasoracetam ADHD study
04:41
the no adverse effect thing is most amazing
04:42
it appears we only need to make it cheaper
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ibtisam.midlet 12-Aug-22 04:50 AM
what the subjective effect was exctly
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ibtisam.midlet
what the subjective effect was exctly
Deleted User 12-Aug-22 04:51 AM
never tried it, most users report anxiolysis, relaxed mood
04:52
most users is actually just a few people
04:52
no one knew about this until they talked to me
04:52
everyone thought 50 mg dose does something before I stepped on deck
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ibtisam.midlet 12-Aug-22 04:53 AM
What's the function of  metabotropic glutamate receptors
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ibtisam.midlet
What's the function of  metabotropic glutamate receptors
Deleted User 12-Aug-22 04:53 AM
pfft there's 7 of them
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Deleted User
no one knew about this until they talked to me
ibtisam.midlet 12-Aug-22 04:53 AM
I take it, I give full report
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ibtisam.midlet
I take it, I give full report
Deleted User 12-Aug-22 04:53 AM
yeah but how much
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ibtisam.midlet 12-Aug-22 04:54 AM
they are involved in learning, memory, anxiety, and the perception of pain
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Deleted User
yeah but how much
ibtisam.midlet 12-Aug-22 04:54 AM
If I take it
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ibtisam.midlet
they are involved in learning, memory, anxiety, and the perception of pain
ibtisam.midlet 12-Aug-22 04:54 AM
Wikipage
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ibtisam.midlet
they are involved in learning, memory, anxiety, and the perception of pain
Deleted User 12-Aug-22 04:55 AM
indeed
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ibtisam.midlet 12-Aug-22 04:55 AM
See there relation
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ibtisam.midlet
See there relation
Deleted User 12-Aug-22 04:58 AM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884290/
mGluR5 positive allosteric modulators facilitate both hippocampal L...
Highly selective positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) have emerged as a potential approach to treat positive symptoms associated with schizophrenia. mGluR5 plays an important role in both long term ...
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04:58
emoji_21
04:59
faso means fire
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ibtisam.midlet 12-Aug-22 05:00 AM
it block learned hopelessness
05:01
https://www.biotune.org/2019/07/what-receptors-do-antidepressants-and.html (edited)
receptors function database
what is antidepressant and how it's work and what receptors act on with full details
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Deleted User 12-Aug-22 05:01 AM
mGluRs are many. they have many functions. we can get a load of effects modulating these
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ibtisam.midlet 12-Aug-22 05:01 AM
Glutamate is a library
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Deleted User 12-Aug-22 05:01 AM
the receptor heteromers only make this more true
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ibtisam.midlet 12-Aug-22 05:03 AM
Look at these
05:03
https://en.m.wikipedia.org/wiki/Proglumide
Proglumide
Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application. An interesting side effec...
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05:03
There a protein that cause your PFC to detect triggers, some people have upregulation in it causing them to be highly reapornsive to placebo/CBT/sensitive to feel rewards, this type of thing inculding placebo in reality not something that not exist , it is product geniunly real effect (edited)
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ibtisam.midlet
https://www.biotune.org/2019/07/what-receptors-do-antidepressants-and.html (edited)
Deleted User 12-Aug-22 05:05 AM
ur golden
05:06
I see u upgraded this from the last time I seen it
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Deleted User
I see u upgraded this from the last time I seen it
ibtisam.midlet 12-Aug-22 05:09 AM
There new superior version
05:09
Still not uploaded
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Deleted User 12-Aug-22 05:09 AM
nice
05:09
lmk
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ibtisam.midlet 12-Aug-22 05:09 AM
I'm trying to make it just show one receptor par time
05:10
When I see it I read it like news paper
05:10
But other people have a hard time lol
05:10
AMPA respect++
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Deleted User 12-Aug-22 05:10 AM
other people have cognitive dysfunction or low IQ
05:11
or just illiterate
05:11
obv there are many more things to add here
05:11
references above all
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ibtisam.midlet 12-Aug-22 05:12 AM
Reference is available click on small point in the cell
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ibtisam.midlet
Reference is available click on small point in the cell
Deleted User 12-Aug-22 05:13 AM
nice didn't notice that
05:13
I wouldn't use wiki as reference tho
05:13
too unreliable
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Deleted User
other people have cognitive dysfunction or low IQ
ibtisam.midlet 12-Aug-22 05:13 AM
I think its due to practice the data a lot , so AMPA duplicated neuron pathway used
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Deleted User 12-Aug-22 05:13 AM
so many things are wrong on wiki, they have broken references, they delete things often
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ibtisam.midlet
I think its due to practice the data a lot , so AMPA duplicated neuron pathway used
Deleted User 12-Aug-22 05:14 AM
yeah data spreadsheet illiterate that's what I meant
05:14
so many people can't even read a simple graph and it's 2022 such a shame and disgrace to humanity
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ibtisam.midlet 12-Aug-22 05:16 AM
Google blocked my blog last week
05:16
Due I made a article named , stop lifying please
05:16
😂
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Deleted User 12-Aug-22 05:17 AM
🥊
05:17
we'll fight dem
05:17
we need powe
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ibtisam.midlet 12-Aug-22 05:17 AM
renamed the article and Contacted them , about that article about nature tell humanity this
05:17
They opens it again
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Deleted User 12-Aug-22 05:18 AM
https://www.youtube.com/watch?v=JivNDRvdhpk
SΣLΣNNΣ
grimes - we appreciate power (slowed + reverb)
emoji_37 1
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Deleted User
https://www.reddit.com/r/Nootropics/comments/wmbpv1/why_alphagpc_and_cdpcholine_can_temporarily_cause/
Yana 12-Aug-22 06:36 AM
This will keep you from pissing clear every 2 minutes
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Yana
This will keep you from pissing clear every 2 minutes
Deleted User 12-Aug-22 06:37 AM
actually it has a diuretic effect until I develop tolerance. this seems to correlate with the negative mood effects
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Deleted User
actually it has a diuretic effect until I develop tolerance. this seems to correlate with the negative mood effects
Yana 12-Aug-22 06:38 AM
Do you develop "tolerance" to anything else besides the endocrine vasopressin effect
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Yana
Do you develop "tolerance" to anything else besides the endocrine vasopressin effect
Deleted User 12-Aug-22 06:40 AM
it appears not. this sucks because my regimen calls for cycling of citicoline one week on one week off. this brings the tolerance back to normal which is bad because it means I'll be fucked up for half of the week
06:40
I cycle it because of TMAO bacteria die off
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Deleted User
I cycle it because of TMAO bacteria die off
Yana 12-Aug-22 06:41 AM
Could you wage a perpetual war with some kind of probiotic?
06:43
Also wait you're saying having elevated antidiuretic hormone has a diuretic effect?
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Yana
Could you wage a perpetual war with some kind of probiotic?
Deleted User 12-Aug-22 06:43 AM
there is too litle info on this sadly. microbiome is largely a mystery. What we do know is that in absence of dietary choline and carnitine these bacteria die off or change their metabolic preferences as shown by the reduced TMAO levels in vegetarians. upon introduction of choline after a week they had the same TMAO levels as omnis
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Yana
Also wait you're saying having elevated antidiuretic hormone has a diuretic effect?
Deleted User 12-Aug-22 06:44 AM
this is because of the MoA of release.
06:44
choline is diuretic itself and the effect appears stronger than the vasopressin release it causes
06:45
so it's not that the elevated vasopressin causes a diuretic effect, it's just that CDP choline has a diuretic effect DESPITE the vasopressin release
🙀 1
06:47
btw look into the cholinergic syndrome prophylaxis
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Deleted User
choline is diuretic itself and the effect appears stronger than the vasopressin release it causes
Yana 12-Aug-22 06:48 AM
ok ok so it's this you're developing tolerance to?
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Deleted User 12-Aug-22 06:48 AM
aCh is a potent secretagogue of everything that comes out of the human body
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Yana
ok ok so it's this you're developing tolerance to?
Deleted User 12-Aug-22 06:48 AM
yes after about 3 days my pissing habits are back to normal
06:48
depending on the rest of the supplementation, hydration and diet ofc
06:49
the negative mood effects are also gone after 3 days
06:50
I can tolerate people again emoji_48
06:50
it's not like I ever like them tho
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ibtisam.midlet 12-Aug-22 07:01 AM
Isn't colinagic is depressive due to muscarine receptors antagonists being drug of abuse
07:02
And produce euphoria
07:03
I'm longterm user of tehyrexphynodyle
07:03
its ultimately develop tolerance where you need to take it once every 23 days to works
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Deleted User 12-Aug-22 07:04 AM
it's multimodal probably.
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ibtisam.midlet 12-Aug-22 07:04 AM
And tolerance develop for euphoria but not for cognitive decline
07:04
So if you analyzed this exp in opposite way
07:05
Then agonists will enhance cognition and decrease mood
07:05
But evenatly you will get just enchantment in cognition
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Deleted User 12-Aug-22 07:06 AM
I think muscarinic activation prevents you to unsee the bad aspects of your own life. So the cognition improving aspect and the decrease in mood is the same thing
07:06
but after a while it is easier to tolerate the negative affect
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ibtisam.midlet 12-Aug-22 07:07 AM
Yeah I thinged about that
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ibtisam.midlet
I'm longterm user of tehyrexphynodyle
Deleted User 12-Aug-22 07:07 AM
what is this
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ibtisam.midlet 12-Aug-22 07:07 AM
It might control neuron that its job is transmittion of bad memory
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Deleted User 12-Aug-22 07:08 AM
yes rumination is exceptionally easy when muscarinic receptors are activated, but more than anything, it is easier to recognize bad intentions of other people which generates a negative worldview quickly
07:09
if everyone around you is ill-intended your life cannot be good logically
07:09
but these are not schizotypal semidelusions, they're realistic examinations of other people
07:10
look at wiki page of negative affect
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ibtisam.midlet 12-Aug-22 07:10 AM
The same problem in memoriesing by M1-5 and understanding of D2
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Deleted User 12-Aug-22 07:10 AM
people with high negative affect are nearly immune to deception
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ibtisam.midlet 12-Aug-22 07:10 AM
Both decrease mood
07:10
In way or other
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Deleted User 12-Aug-22 07:11 AM
also people with negative affect are less likely to discriminate against other races for example
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Deleted User
people with high negative affect are nearly immune to deception
ibtisam.midlet 12-Aug-22 07:11 AM
Nice
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Deleted User 12-Aug-22 07:11 AM
so in my opinion high negative affect is optimal
07:12
but an optimistic worldview needs to be maintained
07:12
because this is correlated to overall life success
emoji_37 1
07:13
problem is that these two are negatively correlated
07:14
so we need to break the correlation between negative affect and pessimism somehow
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ibtisam.midlet 12-Aug-22 07:16 AM
you are thinking like I does (edited)
emoji_21 1
07:16
Thinking after the point where other people stop
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Deleted User 12-Aug-22 07:17 AM
we're gonna burn the world and grow a new one
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Deleted User
so we need to break the correlation between negative affect and pessimism somehow
ibtisam.midlet 12-Aug-22 07:18 AM
I almost did the samething for daltafos b
07:19
Eventually found he relay on nmda association to know what drugs caused euphoria
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ibtisam.midlet
I almost did the samething for daltafos b
Deleted User 12-Aug-22 07:19 AM
my expression is probably very high
07:19
I'm addicted to cycling
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ibtisam.midlet 12-Aug-22 07:19 AM
Then he start unfair selective agreement generation advocate drug use
07:20
Block nmda and your unawareness can't know THC sigarrt is the cause
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Deleted User 12-Aug-22 07:20 AM
I believe the evolutionary usecase of delta fos B is to stimulate locomotor activity and make it hurtful for the organisms to stay still for too long
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ibtisam.midlet 12-Aug-22 07:20 AM
No drug cue
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Deleted User 12-Aug-22 07:20 AM
yes I recovered from THC addiction with memantine
07:21
but it did not decrease propensity for exercise
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Deleted User
I believe the evolutionary usecase of delta fos B is to stimulate locomotor activity and make it hurtful for the organisms to stay still for too long
ibtisam.midlet 12-Aug-22 07:21 AM
I found dalta fos be help me in getting addicted to coding
07:21
It make it less anxious and more pleasurable by decreasing aversion and doing rewards sensitization
07:22
Almost year and half ago I made experiment on codiene
07:22
Took 2 doses 120mg
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Deleted User 12-Aug-22 07:22 AM
of amph?
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ibtisam.midlet 12-Aug-22 07:23 AM
Then waited to see how much craving need to faded
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Deleted User 12-Aug-22 07:23 AM
oh codeine
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ibtisam.midlet 12-Aug-22 07:23 AM
I found that I needed 4 months to forget how opiates look like
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Deleted User 12-Aug-22 07:23 AM
I thought you meant coding 😛
07:23
opiates cause no behavioral sensitization for me
07:24
they cause negative mood states
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ibtisam.midlet 12-Aug-22 07:24 AM
With a half life like this , daily intake will accumulate craving to point having enough dominance to change your opinion
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Deleted User
they cause negative mood states
ibtisam.midlet 12-Aug-22 07:24 AM
What's is this opiate
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Deleted User 12-Aug-22 07:24 AM
dysphoria with a large decrement in attention and overall cognition
07:24
but I tried heroin only
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ibtisam.midlet 12-Aug-22 07:25 AM
People who took hero always not like it first time
07:25
Don't try it again
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Deleted User 12-Aug-22 07:26 AM
I won't it was an accident
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ibtisam.midlet 12-Aug-22 07:26 AM
microdosing codeiene and multi substance formula I talked about was not addictive
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Deleted User 12-Aug-22 07:26 AM
thought it was just cannabis
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ibtisam.midlet 12-Aug-22 07:26 AM
I took 7.5mg /d for 2 month
07:27
blocked depandance in silent phrase by topiramat
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ibtisam.midlet
blocked depandance in silent phrase by topiramat
Deleted User 12-Aug-22 07:38 AM
never knew about that drug it's amazing
07:38
Image attachment
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ibtisam.midlet 12-Aug-22 07:38 AM
I'm trying to find the study
07:38
Anyway
07:39
Its ampa antagonist
07:39
Aftee you stop opiates there 3 days
07:39
Where opiates in not in your system but you still did not get withdrewal
07:40
Its called sielnt phrase
07:40
In this phrase amap work I'm encoding level which we don't know shit about
07:41
To prepare need for withdrawnl execution (some types of depandance not all)
07:42
Then their job end and signal transfired to nmda who will execute it
07:43
Blocking ampa in sielnt phrase block withdrewall symptoms
07:43
Or you will need long term usage of nmda antagonist (21days) for switching bad emotions off
07:44
21 due to median need practice for humans to gain habit is 21days
07:45
Which depende on nmda and habit not always being good and not always awerness mediated, its just sometype of plasticity
07:46
This type of research called biotuning and there group of people like biohackers for it
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Deleted User 12-Aug-22 07:46 AM
biotuners
07:46
more accurate compared to biohackers
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ibtisam.midlet 12-Aug-22 07:48 AM
They analyze things in biological manner without using computional neuroscience, which will cause you to not understand anything lol
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Deleted User 12-Aug-22 07:48 AM
behavioral experiments?
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ibtisam.midlet 12-Aug-22 07:51 AM
Mean what
07:53
?
07:54
Don't mention CBT
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Deleted User 12-Aug-22 07:55 AM
I mean take one substance which is a known agonist of some receptor, take another substance, if it potentiates effect it's a PAM, if it has additive effects it's another agonist and if it cancels effect it's either an inverse agonist or antagonist
07:55
for example
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ibtisam.midlet 12-Aug-22 07:56 AM
Need a lot of cycling time
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Deleted User 12-Aug-22 07:56 AM
obviously these experiments are confounded by many things such as enzymatic interaction, indirect receptor activity, etc.
07:57
unrelated activities may produce similar behavioral effects as well
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ibtisam.midlet 12-Aug-22 07:57 AM
mmm yeah pregabaline opiates
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ibtisam.midlet
mmm yeah pregabaline opiates
Deleted User 12-Aug-22 08:00 AM
IMO these studies are mostly sufficient after thorough in vitro binding activity testing
08:00
but there are always unknown or untested receptors, enzymes, transporters, even modulation of gene expression
08:02
@ibtisam.midlet do you have ideas for safety testing without animals?
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Deleted User
@ibtisam.midlet do you have ideas for safety testing without animals?
Yana 12-Aug-22 08:05 AM
Supercomputing/AI until full-brain/full-organism in silico modeling
08:05
It can happen
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Yana
It can happen
Deleted User 12-Aug-22 08:06 AM
Can happen is not enough for it to happen tho'
08:06
everything that can go wrong will go wrong eventually
08:07
but everything that can go right will rarely go right without intervention
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Yana 12-Aug-22 08:08 AM
Maybe biohack to get superhuman regeneration ability so we can give ourselves organ failure etc. and just replace it
emoji_51 2
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MEE6 BOT 12-Aug-22 08:08 AM
GG @Yana, you just advanced to level 2!
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Deleted User
@ibtisam.midlet do you have ideas for safety testing without animals?
ibtisam.midlet 12-Aug-22 08:08 AM
Taking D3 antagonist and willing to not increase dose more then 25% par day
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Yana
Maybe biohack to get superhuman regeneration ability so we can give ourselves organ failure etc. and just replace it
Deleted User 12-Aug-22 08:09 AM
if I was the other sex I would be hot and moist listening to your fantasies
08:13
https://pubmed.ncbi.nlm.nih.gov/17467122/
Interleukin-1 beta impairs brain derived neurotrophic factor-induce...
The expression of IL-1 is elevated in the CNS in diverse neurodegenerative disorders, including Alzheimer's disease. The hypothesis was tested that IL-1 beta renders neurons vulnerable to degeneration by interfering with BDNF-induced neuroprotection. In trophic support-deprived neurons, IL-1 beta co …
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08:15
https://jneuroinflammation.biomedcentral.com/track/pdf/10.1186/1742-2094-10-59.pdf
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MEE6 BOT 12-Aug-22 08:15 AM
GG @Deleted User, you just advanced to level 11!
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Deleted User 12-Aug-22 08:15 AM
interleukinss have the most annoyingly complex interaction with everything
08:15
even tissue selective modulation is largely unusable becuse of this
08:18
we need time selective modulation for the whole inflammasome it seems however this would require a higher understanding of biomarkers we can use to see if inflammation is necessary at all
08:18
i.e. in infection, injury, etc.
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The Blur 12-Aug-22 09:03 AM
notetake
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MEE6 BOT 12-Aug-22 09:03 AM
GG @The Blur, you just advanced to level 2!
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Deleted User
https://link.springer.com/article/10.1007/s11011-021-00836-y
Netizenne 12-Aug-22 11:47 AM
I’m actually not able to find a study on oxytocin levels in autist’s cerebral spinal fluid -they’ve all stuck to testing blood/serum levels. Honestly it never made sense that oxytocin would be low in autists considering oxytocin promotes a slow life history strategist phenotype -and that autism (imo) seems to be an exemplary slow life history strategist phenotype. But I could be wrong about autism == slow life history strategist phenotype -I’ve heard claims of the contrary. Also autism and schizophrenia share a lot of similarities, having even been considered the same disorder at one point too. (edited)
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Deleted User
https://www.reddit.com/r/Nootropics/comments/wmbpv1/why_alphagpc_and_cdpcholine_can_temporarily_cause/
Netizenne 12-Aug-22 12:11 PM
Omg ur a godsend vegan Prayge Prayge Prayge Prayge Prayge Prayge Prayge
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Deleted User
@ibtisam.midlet do you have ideas for safety testing without animals?
blank 12-Aug-22 12:13 PM
Homeless people 👍
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Deleted User 12-Aug-22 01:08 PM
I feel superhuman
13:08
people on the internet are constantly telling me what I'm doing is impossible
emoji_37 1
13:09
maybe internet people are just pussies tho'
13:09
delta males getting mad about other man's modest success
😂 1
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ibtisam.midlet 12-Aug-22 01:18 PM
Congrats emoji_52
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ibtisam.midlet
Congrats emoji_52
Deleted User 12-Aug-22 01:22 PM
thanks? emoji_1
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Deleted User
Click to see attachment 🖼️
Yana 12-Aug-22 01:27 PM
3 different sneeds? Part bird for sure
13:28
Thinking about basically replacing milch with lentil soup, kale, and calcium carbonate, but I think I can count on one hand the amount of times I've had legumes or leafy greens in my life 💀
13:32
That's so much iron, manganese, and folate dawg
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13:33
I need some deferoxamine
emoji_37 1
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ibtisam.midlet 12-Aug-22 01:34 PM
Buy it?
13:34
I think 50mg would be good dose
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Yana 12-Aug-22 01:37 PM
I'll add it to the potato water
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Deleted User
I am still mesmerized by the fasoracetam ADHD study
Odder_Sea (Glowie) 12-Aug-22 01:42 PM
Something I should look into? I'd like non-stim options for ADD
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Deleted User
there is too litle info on this sadly. microbiome is largely a mystery. What we do know is that in absence of dietary choline and carnitine these bacteria die off or change their metabolic preferences as shown by the reduced TMAO levels in vegetarians. upon introduction of choline after a week they had the same TMAO levels as omnis
Odder_Sea (Glowie) 12-Aug-22 01:46 PM
I've been wondering about this, as I take 600mg of ALCAR and 85mg of citicoline most days. I tend to combine with PQQ, resverateol and a teaspoon of EVOO to hopefully mitigate TMAO conversion, and itherwise eat a high fiber plant-based diet, But I wonder what else can be done to inhibit TMAO and the pathogenic bacteria that produce it (edited)
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Deleted User
maybe internet people are just pussies tho'
Netizenne 12-Aug-22 01:53 PM
Tbh :/
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Odder_Sea (Glowie)
Something I should look into? I'd like non-stim options for ADD
Deleted User 12-Aug-22 02:11 PM
yes you should look into it. but before trying it get gene testing. it's too expensive to be a hit or miss.
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Odder_Sea (Glowie)
I've been wondering about this, as I take 600mg of ALCAR and 85mg of citicoline most days. I tend to combine with PQQ, resverateol and a teaspoon of EVOO to hopefully mitigate TMAO conversion, and itherwise eat a high fiber plant-based diet, But I wonder what else can be done to inhibit TMAO and the pathogenic bacteria that produce it (edited)
Deleted User 12-Aug-22 02:13 PM
dudeee u dropped the L to lowercase. AICAR is another substance.
👍 1
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Deleted User
yes you should look into it. but before trying it get gene testing. it's too expensive to be a hit or miss.
Odder_Sea (Glowie) 12-Aug-22 02:13 PM
TL;DR on the genes in question? I've already been tested
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Deleted User 12-Aug-22 02:13 PM
you won't get any TMAO from that stack
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Odder_Sea (Glowie)
TL;DR on the genes in question? I've already been tested
Deleted User 12-Aug-22 02:14 PM
https://www.nature.com/articles/s41467-017-02244-2
Fasoracetam in adolescents with ADHD and glutamatergic gene network...
Nature Communications - Stimulant drugs are most commonly used to treat ADHD. Here, the authors demonstrate that in adolescents with ADHD who also have genetic variation in genes impacting...
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14:14
look at study for reference (edited)
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Deleted User 12-Aug-22 02:32 PM
Image attachment
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Netizenne 12-Aug-22 02:50 PM
emoji_21 1
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Netizenne
Click to see attachment 🖼️
Deleted User 12-Aug-22 02:50 PM
epilepsy alert
14:51
look at my DM plsss
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Netizenne 12-Aug-22 02:51 PM
oh whoops ya
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Deleted User
look at my DM plsss
Netizenne 12-Aug-22 02:51 PM
Oh right!!!!!@!!!!!!
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The Blur 12-Aug-22 03:35 PM
Thotties
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Deleted User 12-Aug-22 04:29 PM
twoad
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Netizenne
Click to see attachment 🖼️
Yana 12-Aug-22 04:36 PM
https://www.youtube.com/watch?v=mk1KA4A0sr4 (edited)
Needle
GNB Chili - Emotionally Unavailable
16:38
amen break soothes ones soulemoji_51
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Yana
amen break soothes ones soulemoji_51
Deleted User 12-Aug-22 04:40 PM
it rly does
16:43
https://www.youtube.com/watch?v=GsHtHpjgFsg
DJ Smokey
DJ Smokey - "DNA Force" (Official Music Video by @positivepabs)
16:43
this hits diff tho
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Deleted User
Click to see attachment 🖼️
Odder_Sea (Glowie) 12-Aug-22 04:46 PM
I've been assuming you're Gvanebrain on the reddit?
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Deleted User
https://www.youtube.com/watch?v=GsHtHpjgFsg
Yana 12-Aug-22 04:48 PM
He's selling spiral energy from Gurren Lagann
16:48
He already sells pregnenolone and calls it 'the real red pill'
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Odder_Sea (Glowie)
I've been assuming you're Gvanebrain on the reddit?
Deleted User 12-Aug-22 04:48 PM
yes
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Yana
He's selling spiral energy from Gurren Lagann
Deleted User 12-Aug-22 04:50 PM
his supplements have no merit. but his infomercials are perfect mixtape food.
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Yana 12-Aug-22 04:51 PM
https://www.youtube.com/watch?v=5X9RUOEOoNQ
nuncaleite
Alex Jones explains Evangelion to Joe Rogan
16:51
Shadowbanned video
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Odder_Sea (Glowie)
I've been assuming you're Gvanebrain on the reddit?
Deleted User 12-Aug-22 04:56 PM
https://www.reddit.com/r/gvane/comments/wlo665/the_connection_between_occupational_reward/
r/gvane - The Connection Between Occupational Reward, Vesicular Neu...
2 votes and 0 comments so far on Reddit
16:56
read my write up
16:57
join the subreddit ur even vegan
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Yana
https://www.youtube.com/watch?v=5X9RUOEOoNQ
blank 12-Aug-22 04:57 PM
Alex Jones is sadly a fraud but this is so entertaining to listen to
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blank
Alex Jones is sadly a fraud but this is so entertaining to listen to
Deleted User 12-Aug-22 04:59 PM
I will be the next Alex Jones but with real supplements emoji_50
17:00
plot twist: keeping the tomes for myself. I'll be the smartest person on the planet
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Yana 12-Aug-22 05:00 PM
@Deleted User I thought vegans were supposed to be anemic lol
Image attachment
17:01
EZ
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Yana
@Deleted User I thought vegans were supposed to be anemic lol
Deleted User 12-Aug-22 05:01 PM
yeah I'm near anemic despite more than 50 mg dietary iron daily
17:01
I consider this a good thing
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Yana 12-Aug-22 05:01 PM
But how
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Deleted User 12-Aug-22 05:01 PM
stupid doc told me I'm prolly depressed because of this
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Yana 12-Aug-22 05:01 PM
Oh yeah heme exists
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Deleted User 12-Aug-22 05:02 PM
took high dose D3 and rested for a while the bad mood went away
17:02
still near anemic
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Yana 12-Aug-22 05:02 PM
is this off blood tests
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MEE6 BOT 12-Aug-22 05:02 PM
GG @Yana, you just advanced to level 3!
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Yana
is this off blood tests
Deleted User 12-Aug-22 05:02 PM
yes
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Yana 12-Aug-22 05:03 PM
So proud
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Yana
So proud
Deleted User 12-Aug-22 05:03 PM
vegan diet is naturally full of iron chelators
17:04
i.e. polyphenols
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Yana 12-Aug-22 05:04 PM
Need to get my plant compund knowledge up 💯 like you
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Yana
Need to get my plant compund knowledge up 💯 like you
Deleted User 12-Aug-22 05:17 PM
that's what she said
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komodo dragon 12-Aug-22 06:31 PM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572771/
A Thalamic Orphan Receptor Drives Variability in Short-Term Memory
Working memory is a form of short-term memory that involves maintaining and updating task-relevant information toward goal-directed pursuits. Classical models posit persistent activity in prefrontal cortex (PFC) as a primary neural correlate, but emerging ...
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Deleted User
vegan diet is naturally full of iron chelators
Odder_Sea (Glowie) 12-Aug-22 07:21 PM
I've been taking Primavie Shilajit, which I suspect helps protect from anemia
19:22
But IMO borderline insufficient iron stores are superior to excess iron, by a long shot
👍 1
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komodo dragon
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572771/
Netizenne 12-Aug-22 07:51 PM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226366/ Responsible for 17% of variance in working memory in mice and is agonized by sphingosine 1 phosphate ????? Also related to CB1 receptor. (edited)
Advances in Neurobiology and Pharmacology of GPR12
GPR12 is a G protein-coupled orphan receptor genetically related to type 1 and type 2 cannabinoid receptors (CB[1] and CB[2] ) which are ancient proteins expressed all over the body. Both cannabinoid receptors, but especially CB[1] , are involved in ...
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Netizenne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226366/ Responsible for 17% of variance in working memory in mice and is agonized by sphingosine 1 phosphate ????? Also related to CB1 receptor. (edited)
komodo dragon 12-Aug-22 08:26 PM
God knows it's still an orphan recrptor
20:26
Endogenous ligands are in the grey area
20:26
CBD is an inverse agonist
20:26
Some neuropeptide is an agonist
20:28
Nesfatin-1
20:29
The receptor is related to LPA (edited)
20:29
MCR
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komodo dragon
God knows it's still an orphan recrptor
Netizenne 12-Aug-22 08:29 PM
Oh fair lol, I retracted closely from related (edited)
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komodo dragon 12-Aug-22 08:29 PM
Nah it's related to cannabinoid receptors by homology
20:30
MCR too
20:30
All I know is that it's a very promising target for cognition
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komodo dragon
MCR too
Netizenne 12-Aug-22 08:30 PM
That is interesting
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komodo dragon 12-Aug-22 08:30 PM
Well working memory aspect specifically (edited)
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Netizenne 12-Aug-22 08:38 PM
I gotta find an evolutionary tree of g coupled protein receptors evolution
20:38
A hierarchical taxonomy of how they all diverged
20:38
Probably would reveal a lot
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komodo dragon 12-Aug-22 08:39 PM
I'm gonna look into more gpcrs and orphan receptors for cognition
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MEE6 BOT 12-Aug-22 08:39 PM
GG @komodo dragon, you just advanced to level 1!
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komodo dragon 12-Aug-22 08:39 PM
:D
20:39
GPR139 is interesting
20:39
How it antagonizes MOR and is co-expressed with D2
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komodo dragon
I'm gonna look into more gpcrs and orphan receptors for cognition
Netizenne 12-Aug-22 08:45 PM
Novel targets are cool cause we might accidentally find a new way to get high if we’re lucky loool (edited)
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Odder_Sea (Glowie)
But IMO borderline insufficient iron stores are superior to excess iron, by a long shot
Deleted User 13-Aug-22 01:36 AM
indeed, less oxidation, esp in dopaminergic neurons which is important for Parkinson's prevention
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Netizenne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226366/ Responsible for 17% of variance in working memory in mice and is agonized by sphingosine 1 phosphate ????? Also related to CB1 receptor. (edited)
Deleted User 13-Aug-22 01:37 AM
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Deleted User
indeed, less oxidation, esp in dopaminergic neurons which is important for Parkinson's prevention
Odder_Sea (Glowie) 13-Aug-22 01:44 AM
I think excess iron is also involved in lipofuscin and amyloid plaques.
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Netizenne
Novel targets are cool cause we might accidentally find a new way to get high if we’re lucky loool (edited)
Deleted User 13-Aug-22 01:46 AM
I did find a new way to get high but I can't disclose it because the community is a shithole stealing novel substances to make money. Whoever doesn't steal likes talking and it eventually ends up with Sirsad
01:47
I won't be a psychedelic Nikola Tesla. My fate is to be crowned as the toad king
01:48
Image attachment
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Deleted User
I won't be a psychedelic Nikola Tesla. My fate is to be crowned as the toad king
Odder_Sea (Glowie) 13-Aug-22 01:50 AM
Image attachment
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Odder_Sea (Glowie)
Click to see attachment 🖼️
Deleted User 13-Aug-22 02:12 AM
Funny thing I had a CEV the other day of a unicorn prince fetus. He was pretty, shiny and cute
02:13
gotta make it with MJ
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͘                 вυɩɩϲҺίϲ𝗄е𝗇360 13-Aug-22 02:21 AM
hi
02:21
is this a nootropic server? i joined from a random invite
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͘                 вυɩɩϲҺίϲ𝗄е𝗇360
is this a nootropic server? i joined from a random invite
Deleted User 13-Aug-22 02:33 AM
advanced biohacking
02:33
mostly cognitive enhancement but also longevity
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͘                 вυɩɩϲҺίϲ𝗄е𝗇360 13-Aug-22 02:33 AM
cool
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Deleted User 13-Aug-22 02:43 AM
https://www.youtube.com/watch?v=JivNDRvdhpk
SΣLΣNNΣ
grimes - we appreciate power (slowed + reverb)
02:43
time for 30 mg memantine
02:45
ohh not today
02:45
tomorrow
02:45
lol
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deepAI 13-Aug-22 02:59 AM
@Deleted User
02:59
let me finish at least
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deepAI
let me finish at least
Deleted User 13-Aug-22 03:01 AM
watch your step
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deepAI 13-Aug-22 03:02 AM
it is your decision, but if you idea is to learn
03:02
is to enhance learning
03:02
you are missing the %50 of the stuff
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Original message was deleted or could not be loaded.
deepAI 13-Aug-22 03:03 AM
this is the %50 of the job
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Deleted User 13-Aug-22 03:05 AM
I said what I said. You acting like you know me for the past 10 years and have been studying beside me makes you look dumb and rude. Don't hmu until you change yourself again
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deepAI 13-Aug-22 03:06 AM
whatever
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Deleted User 13-Aug-22 03:06 AM
Image attachment
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deepAI 13-Aug-22 03:08 AM
take care, predators out there.
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Deleted User 13-Aug-22 03:53 AM
i really expected snorting modafinil to hurt
03:53
i was wrong
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Deleted User
i really expected snorting modafinil to hurt
Deleted User 13-Aug-22 04:00 AM
armoda?
04:01
regular moda
04:01
w fillers
04:01
Image attachment
04:01
presumably
04:01
toad king checking in. mossy branch cozy
04:01
moissst
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Deleted User
w fillers
Deleted User 13-Aug-22 04:02 AM
pleb shit
04:02
ill have you know the indians are very competent
04:03
obv
04:03
the prob is that you buy pills not powders
04:03
has emi teached you nothing
04:03
where you gonna get modafinil powder
04:03
i have thousands of $ of powders
04:03
and no pills except this sort of shit
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Deleted User
where you gonna get modafinil powder
Deleted User 13-Aug-22 04:04 AM
I have pure armoda emoji_51
04:04
ok well wheres mine
04:04
i have fladra powder
04:04
where the plug at yyooo
04:04
https://www.youtube.com/watch?v=ftpTM3BzIIs
ultra-violence
lil peep - toxic city 💖
04:05
NAC kills moda just like it does amps and phenidates\
04:05
hopefully enough time between
04:05
NAC has abysmal half life
04:05
i posted more shit in my noot channel today than in 2 months
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Deleted User
NAC has abysmal half life
Deleted User 13-Aug-22 04:06 AM
yea
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Deleted User
i posted more shit in my noot channel today than in 2 months
Deleted User 13-Aug-22 04:06 AM
obv
04:06
i also started learning algebra 2 to increase grey matter
04:06
Moda is next gen caffeine
04:06
i just now took it
04:07
i take it every work day
04:07
caffeine propelled humanity to industrial revolution, moda is about to propell humanity to become a new species
04:07
im just inducing a hypomanic strreak
04:07
hypomania is not even a thing
04:07
i must stay up 5 days 🙂
04:07
or else ill panic
04:08
jail in 6 days v possible
04:08
now that's where you made the mistake
04:08
i have to make the most of my time
04:08
I sleep erry day
04:08
8 hours
04:08
i do too
04:08
this is extenuating circumstances
04:08
btw almost subL'd 150 mg DHF
04:08
kek
04:08
want me to follow
04:08
didn't even look at the scale
04:09
i eyeball errything lol
04:09
I did scale it in the last sec before it entered my mouth
04:09
once youve weighed everytthing you take out for 2 years
04:09
no point anymore unless your dumb
04:10
well I don't trust my judgement
04:10
tho' it is very accurate
04:10
this time didn't even think about the amount
04:11
I'm pretty sure nothing bad would happen anyways
04:11
meh its anti hypertensive anyways
04:12
whats worsdt case
04:12
oh kay moda is kicking in
04:12
intruiging
04:12
much head warmth from insuff
04:12
well i gotta get back to research
04:13
ttyl
04:13
you can see whatever i find in my serber
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Deleted User
you can see whatever i find in my serber
Deleted User 13-Aug-22 04:14 AM
will talk to you tomorrow
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Deleted User 13-Aug-22 04:45 AM
is it a dihexa day?
04:45
its always a risk but this game is risky
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Deleted User
is it a dihexa day?
judas 13-Aug-22 04:45 AM
What’s your usually day after you take something like Dihexa
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Deleted User 13-Aug-22 04:46 AM
well, if it goes well cognition increases a lot
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Deleted User
is it a dihexa day?
Deleted User 13-Aug-22 04:46 AM
it's never an exogenous oligopeptide day
04:46
if it doesnt, iget bad brain fog
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judas 13-Aug-22 04:46 AM
I would like play different sports all day
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Deleted User 13-Aug-22 04:46 AM
dihexa is the definition of a coinflip noot for me
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judas
I would like play different sports all day
Deleted User 13-Aug-22 04:46 AM
I like to push the pedal for 12 hours a day
04:46
the more i use it the worse brainfog
04:47
but its been 4.5 months since i dosed it
04:47
and that was 5 doses in 3 days
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Deleted User
the more i use it the worse brainfog
judas 13-Aug-22 04:47 AM
Makes sense considering what it does
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Deleted User 13-Aug-22 04:47 AM
DIHEXA is retarded
04:47
question is
04:47
is my current state one that would benefit from it
04:47
even endogenous BDNF is retarded most times
04:48
elucidate me as to when dihexa would be optimal
04:48
NO BIASES
04:48
and no cancer propoganda!
04:48
when intraneuron chloride concentration is very low
04:48
same as BDNF
04:48
hmmmmm
04:48
exercise stimulated BDNF releases chloride
04:49
drug stimulated BDNF usually does the opposite
04:49
I would guess DIHEXA does what BDNF secretagogues do to an extreme level
04:49
im probably about to do retarded
04:49
lemme flip a coin
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Deleted User
even endogenous BDNF is retarded most times
judas 13-Aug-22 04:49 AM
Ngl you’re right I realized this recently
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Deleted User 13-Aug-22 04:49 AM
I took too much DHF
04:50
lol
04:50
welp
04:50
I have to go push the pedal for 10 hrs straight now
04:50
i took a 4 dma 78 dhf when you dosed
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judas 13-Aug-22 04:50 AM
I got bored of using DHF
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Deleted User 13-Aug-22 04:50 AM
its best acutely
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judas 13-Aug-22 04:51 AM
I realized that
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MEE6 BOT 13-Aug-22 04:51 AM
GG @judas, you just advanced to level 1!
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Deleted User 13-Aug-22 04:51 AM
daily sucks for me
04:51
Leaf lemme ask you
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judas 13-Aug-22 04:51 AM
I was taking it daily for a week before I realized
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Deleted User 13-Aug-22 04:51 AM
r u capable of DJing
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judas 13-Aug-22 04:51 AM
Then did a cycle of Polygala after
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Deleted User
r u capable of DJing
Deleted User 13-Aug-22 04:51 AM
only if your tripping
04:51
I was thinking
04:52
we could increase group cohesion if we had a radio channel
04:52
yea we need one
04:52
i mean i can play my stuff
04:52
but i cant guarantee it will be optimal
04:52
@Netizenne u play your breakcore. I trust you not to break my heart
04:52
oh ik
04:53
just play savant
04:53
all autists love savant
04:53
ive been on a white person music meme lately tho
04:53
I'll spin ambient
04:54
choose your weapon @Deleted User
04:54
youd play elevator music
04:54
and like it
04:55
classical psychedelic ambient
04:56
ima play whats it called
04:56
makes me think of blimps
04:58
welpi cant remember
04:58
so id play dirty heads, kanye and watsky
04:58
it's hard to find music that imbues emotion yet doesn't trigger autistic misophonia
04:59
Image attachment
04:59
i hated music most of my life
04:59
Image attachment
04:59
it just
04:59
was boring or too many bpm
04:59
always think of these objects when I say this word
05:00
i want that soup now you fucker
05:00
ima murder you in my sleep
05:00
me too
05:00
but I don't have time for cooking
05:00
I have to push pedals
05:00
or else I will become retarded soon
05:01
today is the day
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MEE6 BOT 13-Aug-22 05:01 AM
GG @Deleted User, you just advanced to level 8!
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Deleted User 13-Aug-22 05:01 AM
i think
05:01
yea bot agrees
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Deleted User
yea bot agrees
Deleted User 13-Aug-22 05:01 AM
no
05:01
p sure the hottest girl at work is working today
05:01
stop with the superstition
05:01
it will KILL YA
05:01
time to get a number
05:02
oh trust me, im way better at killing myself than superstition is
05:02
alcohol is anti superstition
05:02
and im an alcy
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Deleted User
time to get a number
Deleted User 13-Aug-22 05:02 AM
remember to lean against the wall, tilt your head, take a deep breath, sigh and squint your eyes before you say anything
05:02
thats
05:02
wel its a new one
05:03
i mean she always tries to talk to me
05:03
p sure its in the bag, along w schrodingers cat (i catnapped it)
05:03
catnipped?
05:03
i stole his cat
05:04
it's kinda rude
05:04
should have at least bribed it with catnip
05:04
HE WAS KILLING IT
05:05
yay I have a first reddit follower
05:05
Ok this is what happens when autism begets autism begets autism
05:06
reddit is weird
05:06
i have the best drug potentiation guide on reddit kekek
05:06
I have a feeling all of the users are obese and easy to trigger
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Deleted User
i have the best drug potentiation guide on reddit kekek
Deleted User 13-Aug-22 05:06 AM
link twink
05:07
https://www.reddit.com/r/Drugs/comments/hk0yiv/the_ultimate_drug_potentiation_guide_updated/
r/Drugs - [NSFW] The ultimate drug potentiation guide [Updated]
196 votes and 91 comments so far on Reddit
05:07
old
05:07
and no sources kek
05:07
also missing shit as of now
05:07
i could double the length now
05:07
no homo
05:07
some homo?
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Deleted User
some homo?
Deleted User 13-Aug-22 05:08 AM
boss
05:08
nah im just an employee
05:09
the psychedelic aspect is prob most focused on in that guide
05:09
i need take quercetinnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn
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Deleted User
https://www.reddit.com/r/Drugs/comments/hk0yiv/the_ultimate_drug_potentiation_guide_updated/
Deleted User 13-Aug-22 05:10 AM
cognitively dysfunctional ideas
05:10
I can see why you're fucked
05:10
oh definitely
05:10
thats just the start
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Deleted User
nah im just an employee
Deleted User 13-Aug-22 05:10 AM
I'm the boss
05:10
half of those ideas prolly kill a lot of braincells
05:10
all the psych potentiation does
05:11
farily sure
05:11
yes
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MEE6 BOT 13-Aug-22 05:11 AM
GG @Deleted User, you just advanced to level 12!
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Deleted User 13-Aug-22 05:11 AM
also: benzo potentiation
05:11
however, i have proven noopept potentiates lsd 3x w my free mice
05:12
they tilted their heads at a 3 times higher angle
05:12
black humor is how slavs deal with emotional distress
05:13
thats racist
05:13
should say dark humor
05:13
your just negging them at this point
05:16
if rapamycin wasnt hypertensive i prob would have snorted it all already (edited)
05:22
theres a 33% chance dihexa works great if i take today
05:22
66% it causes brainfog
05:22
1% chance i die
05:22
hmmmm
05:23
tis a thonker for certain
05:25
wheres my muse, i need inspiration
05:28
"Therapeutic sleep deprivation (SD) is a rapid acting treatment for major depressive disorder (MDD). Within hours, SD leads to a dramatic decrease in depressive symptoms in 50–60% of patients with MDD."
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Deleted User
ok well wheres mine
ibtisam.midlet 13-Aug-22 05:41 AM
See this adrafinil is insanely cheap there online vendors meta search engine: https://nootropicsindex.com/
Nootropics Product Comparison | Nootropics Index
Find out where you can buy nootropics. Compare prices for all vendors worldwide. Filter by type: capsules, powder or solution. Sort products by price per gram, price per capsule or product price. Show listed products based on their content and weight.
05:41
Di you have better price?
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Deleted User 13-Aug-22 05:43 AM
adrafinil is shit tho
05:43
even fladra is p shit
05:43
i havent tried armoda
05:44
but only moda is based for me so far
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ibtisam.midlet 13-Aug-22 05:44 AM
Do you have better price for any of them
05:44
Like dirty cheap
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Deleted User
i havent tried armoda
veganpermanently 13-Aug-22 05:45 AM
Armoda is the based part of racemic Moda. You can expect double potency
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Deleted User 13-Aug-22 05:49 AM
steal it from indians
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Deleted User
i could double the length now
blank 13-Aug-22 05:59 AM
do it emoji_49
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Deleted User 13-Aug-22 06:02 AM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498068/
MC159 of Molluscum Contagiosum Virus Suppresses Autophagy by Recrui...
MC159 is a viral FLIP (FLICE inhibitory protein) encoded by the molluscum contagiosum virus (MCV) enabling MCV to evade antiviral immunity and to establish persistent infections in humans. Here, we show that MC159 contains a functional SH3 binding motif, ...
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06:03
My "benign" viral infection
06:03
Your gonna tell me a virus is benign if it impairs ability for autophagy?
06:03
If I continue to have it it will almost certainly shorten lifespan
06:04
This is why rapamycin is the cure tho
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Deleted User 13-Aug-22 06:28 AM
oh hey rapamycin fixes that 🙂
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ibtisam.midlet 13-Aug-22 06:30 AM
@everyone This backup server invite https://discord.gg/Ahx3kVsp69 Join it, It just backup users you can't read/write or get notified from it.
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Deleted User 13-Aug-22 06:31 AM
i uhhhh, likely found a cure to an incurable virus
06:31
i just got lucky
06:31
the autophagy inhbition from molluscum is reveresed by rapamycin
06:31
BOOM
06:33
the science is in my server and the mouse is me lol
06:33
but also just fasting for a month should cure it
06:34
i admit the science is still weak
06:34
but theres enough connections for it to be a trialable hypothesis
06:34
if any researchers actually gave 2 shits
06:36
why do you think i dont own my own server
06:36
its a precaution
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ibtisam.midlet 13-Aug-22 06:39 AM
Stop misleading members
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MEE6 BOT 13-Aug-22 06:50 AM
GG @ibtisam.midlet, you just advanced to level 12!
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ibtisam.midlet 13-Aug-22 06:52 AM
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Deleted User 13-Aug-22 07:03 AM
uhm
07:03
i developed the ability to type eyes closed overnight
07:03
what the actual fuck
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ibtisam.midlet 13-Aug-22 07:06 AM
The attention deficit if was a human
07:06
take risperidone +_+
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Deleted User 13-Aug-22 07:17 AM
you first
07:17
and take mine too babe
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ibtisam.midlet 13-Aug-22 07:21 AM
Doing x10 hard work to increase task quality from 95% to 99% will destroy your life
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Deleted User 13-Aug-22 07:26 AM
I don't afaik
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ibtisam.midlet 13-Aug-22 07:36 AM
you might just addicted to baseline
07:36
dalta fos b can close your eyes
07:37
Happen to me
07:37
Just try things even if you thing they are useless
07:38
It will lead to a lot of discoveries
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ibtisam.midlet 13-Aug-22 07:51 AM
BTW @Deleted User does modafinil halped you
07:52
What's the substances that can suck dick of coffee for you
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Deleted User 13-Aug-22 07:52 AM
I hate baseline
07:52
I love moda
07:52
I hate amphetamine
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ibtisam.midlet 13-Aug-22 07:53 AM
Yeah amp induce psychosis
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Deleted User 13-Aug-22 07:53 AM
Also just terrible for health
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ibtisam.midlet 13-Aug-22 07:53 AM
beta blocker and you eliminated the heart side effect of it
07:53
Tested before and works
07:54
Between you lost some rewards due to blockage of beta
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Deleted User 13-Aug-22 07:54 AM
Yea yea but I'd rather profit off the amp
07:54
Theoretically
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ibtisam.midlet 13-Aug-22 07:55 AM
Cycling meds was not effective for me , I ended using 10 and everyone of them started to work once every month
07:55
Now I seek new receptors to fuck with
07:56
Found that a lot of emotions like optamistic is controled by widely unknown receptors
07:56
I'm reward travaler
08:03
@Sirsadalot do you have private emoji pack to rob
08:05
Controlling servers from a phone is awsome BTW!!
08:07
finally
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Deleted User 13-Aug-22 08:09 AM
Oh I see, sirsad is here but not my server
08:09
raises fist
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ibtisam.midlet 13-Aug-22 08:09 AM
@abcd develop some plasticity from reading channels here, you would feel a stranger in first
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Deleted User
Oh I see, sirsad is here but not my server
ibtisam.midlet 13-Aug-22 08:11 AM
just act like its yours, in good way
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Deleted User 13-Aug-22 08:12 AM
I'm taking piracetam rn @Sirsadalot
08:12
Btw, 44 g piracetam in 2 days is too much
08:12
Just a heads up
08:15
I always imagine suboxone delivery when I see #subs-delivery
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ibtisam.midlet 13-Aug-22 08:16 AM
@abcd I invited you to sirsad server and other one, they are one of the best biohacking servers here
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Deleted User 13-Aug-22 08:17 AM
Invite me too
08:17
To sirs
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Deleted User
Btw, 44 g piracetam in 2 days is too much
ibtisam.midlet 13-Aug-22 08:17 AM
When was the first time you took it
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Deleted User 13-Aug-22 08:17 AM
4 years ago
emoji_37 1
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Deleted User
Invite me too
ibtisam.midlet 13-Aug-22 08:17 AM
Sirsad depandanat
08:18
Did he banned you
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Deleted User 13-Aug-22 08:18 AM
No I lefted
08:18
A few weeks agos
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ibtisam.midlet 13-Aug-22 08:18 AM
I invited you to one
08:18
Wait
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Deleted User 13-Aug-22 08:19 AM
Wronk one
08:19
But I'm upset w gintrux for not inviting me to that one
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ibtisam.midlet 13-Aug-22 08:19 AM
take lamotrigin to not feel such emotions
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ibtisam.midlet 13-Aug-22 08:28 AM
I have chemical solution for everything emoji_49
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Deleted User
i developed the ability to type eyes closed overnight
Deleted User 13-Aug-22 08:57 AM
unimpressive tbh
08:57
learned this at 9 yrs old or so
08:58
however word count is hard to get up for me
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Deleted User
But I'm upset w gintrux for not inviting me to that one
Deleted User 13-Aug-22 08:59 AM
nothing lost no opportunity of gain lost either
08:59
https://www.youtube.com/watch?v=eQ9yp_9PanM
HighFocusTV
Lee Scott - Spaced (OFFICIAL VIDEO) (Prod. Dirty Dike)
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Deleted User
unimpressive tbh
Deleted User 13-Aug-22 09:03 AM
I was retarded at 9 and only passed typing class bc no teacher is gonna fail someone for typing class lmao
09:04
It's a dramatic increase for me to gain that ability at random
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Deleted User
I was retarded at 9 and only passed typing class bc no teacher is gonna fail someone for typing class lmao
Deleted User 13-Aug-22 09:07 AM
we had no typing class I was just geekin my whole life
09:08
I'm not even human
09:14
https://soundcloud.com/milkavelli616/geekin
Milkavelli616
GEEKIN
PRODUCED BY OMELET
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Deleted User
I did find a new way to get high but I can't disclose it because the community is a shithole stealing novel substances to make money. Whoever doesn't steal likes talking and it eventually ends up with Sirsad
Netizenne 13-Aug-22 11:37 AM
:(
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ibtisam.midlet 13-Aug-22 11:50 AM
who care for being credited
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Netizenne 13-Aug-22 11:57 AM
yesegg
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Deleted User
I did find a new way to get high but I can't disclose it because the community is a shithole stealing novel substances to make money. Whoever doesn't steal likes talking and it eventually ends up with Sirsad
blank 13-Aug-22 12:05 PM
Sell it yourself emoji_49
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Deleted User 13-Aug-22 12:13 PM
@veganpermanently are u mad hatterz?
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Netizenne 13-Aug-22 01:22 PM
They indeed are lool (edited)
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ibtisam.midlet
who care for being credited
Deleted User 13-Aug-22 01:23 PM
it's nice to be credited but making money off of someone else's idea is straight Edison BS
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blank
Sell it yourself emoji_49
Deleted User 13-Aug-22 01:25 PM
Nootropic company from Croatia? you must be joking or don't know the situation here
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Deleted User
Click to see attachment 🖼️
Netizenne 13-Aug-22 01:25 PM
It was yanas find
13:25
Yana Prayge
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Netizenne
Yana Prayge
Yana 13-Aug-22 01:25 PM
@komodo dragon 's
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Deleted User 13-Aug-22 01:26 PM
eggg
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Yana 13-Aug-22 01:26 PM
emoji_44
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Deleted User
Nootropic company from Croatia? you must be joking or don't know the situation here
blank 13-Aug-22 01:26 PM
emoji_52
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Deleted User 13-Aug-22 01:26 PM
13:26
@komodo dragon
13:27
I have been told multiple times I look like Michael Jackson
13:27
I can't see the resemblance at all
13:27
was wondering why people make these funny connections
13:28
many times someone says someone looks like someone else but to me never
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Deleted User
Nootropic company from Croatia? you must be joking or don't know the situation here
blank 13-Aug-22 01:28 PM
or maybe a partnership with an already established noot shop
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blank
or maybe a partnership with an already established noot shop
Deleted User 13-Aug-22 01:28 PM
tried that with sirsa
13:28
went well
13:30
best solution is to move out of this beautiful hell
13:30
tho' my heart jumps a beat just thinking about it
13:31
https://www.youtube.com/watch?v=0kf8ibi15tU
K.Flay
K.Flay - FML [Official Video]
13:32
@ibtisam.midlet what's your chemical solution for heartbreak
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Deleted User
was wondering why people make these funny connections
komodo dragon 13-Aug-22 01:33 PM
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13:33
do he look like dababy?
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komodo dragon
do he look like dababy?
Deleted User 13-Aug-22 01:33 PM
he looks like A baby
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komodo dragon 13-Aug-22 01:33 PM
lmfao
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Deleted User 13-Aug-22 01:37 PM
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Deleted User
Click to see attachment 🖼️
komodo dragon 13-Aug-22 01:44 PM
was that made using midjourney
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komodo dragon
was that made using midjourney
Deleted User 13-Aug-22 01:44 PM
yes
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komodo dragon 13-Aug-22 01:44 PM
looks rly cool
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Deleted User 13-Aug-22 01:45 PM
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13:45
toad king in natural environment
13:45
midjourney is insane powerful
13:46
I decided to use substances and have fun in midjourney all winter until I go crazy
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komodo dragon 13-Aug-22 01:46 PM
generate a hyperrealistic watermelon!
13:47
if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
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Deleted User 13-Aug-22 01:47 PM
🍉
13:47
G
13:48
I just crushed a few kgs of watermellow
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komodo dragon 13-Aug-22 01:48 PM
dam fr
13:48
why
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Deleted User 13-Aug-22 01:49 PM
kek did you even read my spam
13:49
it's not just for spam it's to send a message you know
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komodo dragon 13-Aug-22 01:52 PM
uhh
13:52
wheres your spam 😅
13:52
didnt read it no
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komodo dragon
wheres your spam 😅
Deleted User 13-Aug-22 01:53 PM
if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
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komodo dragon
why
Deleted User 13-Aug-22 01:53 PM
if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
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komodo dragon
didnt read it no
Deleted User 13-Aug-22 01:53 PM
if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
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komodo dragon 13-Aug-22 01:53 PM
yea but why crush it
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Netizenne 13-Aug-22 01:53 PM
if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
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komodo dragon 13-Aug-22 01:53 PM
was the watermelon looking at you funny
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komodo dragon
was the watermelon looking at you funny
Deleted User 13-Aug-22 01:53 PM
if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
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komodo dragon
yea but why crush it
Deleted User 13-Aug-22 01:53 PM
if you pee is not clear here's a watermelon. it tastes nice, it's exceptionally hydrating and makes your snake fat, pent up and ready to strike. 🍉
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komodo dragon 13-Aug-22 01:54 PM
i love watermelons man im not a hater
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komodo dragon
i love watermelons man im not a hater
Deleted User 13-Aug-22 01:56 PM
btw do you know which melon is the best
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komodo dragon 13-Aug-22 01:57 PM
no
13:57
which is the best 1
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Deleted User 13-Aug-22 01:57 PM
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komodo dragon 13-Aug-22 01:57 PM
ive seen those somewhere
13:57
dont know what theyre called
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Deleted User 13-Aug-22 01:57 PM
pure sugar
13:57
also highest in citrulline
13:58
the stats that eating 5 kg of watermelon is like consuming a citrulline supplement is for this one
13:58
not for the red one
13:58
that will never provide enough citrulline
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komodo dragon 13-Aug-22 01:58 PM
makes your snake fat, pent up and ready to strike!
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MEE6 BOT 13-Aug-22 01:58 PM
GG @komodo dragon, you just advanced to level 2!
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komodo dragon
makes your snake fat, pent up and ready to strike!
Deleted User 13-Aug-22 01:59 PM
tho you can crush the seeds of a normal one and still get a fat snake
13:59
bcs of arginine content
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komodo dragon 13-Aug-22 02:00 PM
🐍
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Potential 13-Aug-22 04:02 PM
So far Sialic acid is feeling really good. For those that don't know, Edible Bird's Nest as a Potential Cognitive Enhancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120600/ Molecular Mechanism Underlying Sialic Acid as an Essential Nutrient for Brain Development and Cognition https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649484/ Sialic acid is an essential nutrient for brain development and cognition https://pubmed.ncbi.nlm.nih.gov/19575597/ now you know.
Edible Bird's Nest as a Potential Cognitive Enhancer
Cognitive enhancement is defined as the augmentation of the mind's core capabilities through the improvement of internal or external information processing systems. Recently, the focus has shifted to the potential therapeutic effects of natural products ...
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Molecular Mechanism Underlying Sialic Acid as an Essential Nutrient...
The early stages of neurodevelopment in infants are crucial for establishing neural structures and synaptic connections that influence brain biochemistry well into adulthood. This postnatal period of rapid neural growth is of critical importance for cell ...
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Sialic acid is an essential nutrient for brain development and cogn...
The rapid growth of infant brains places an exceptionally high demand on the supply of nutrients from the diet, particularly for preterm infants. Sialic acid (Sia) is an essential component of brain gangliosides and the polysialic acid (polySia) chains that modify neural cell adhesion molecules (NCA …
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Potential
So far Sialic acid is feeling really good. For those that don't know, Edible Bird's Nest as a Potential Cognitive Enhancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120600/ Molecular Mechanism Underlying Sialic Acid as an Essential Nutrient for Brain Development and Cognition https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649484/ Sialic acid is an essential nutrient for brain development and cognition https://pubmed.ncbi.nlm.nih.gov/19575597/ now you know.
Deleted User 13-Aug-22 04:04 PM
what r u using
16:05
pure sialic acid?
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Deleted User
that will never provide enough citrulline
Odder_Sea (Glowie) 13-Aug-22 04:05 PM
What about the rinds?
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Deleted User
pure sialic acid?
Potential 13-Aug-22 04:05 PM
Pure.
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Potential
Pure.
Deleted User 13-Aug-22 04:06 PM
can u provide sauce
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Potential 13-Aug-22 04:08 PM
Sauce is from Gintrux but I've found a vendor that also sells. https://nextvalley.com/shop/sialic-acid/?attribute_pa_package=180-capsules&attribute_pa_dose=100-mg&cgkit_search_word=sialic
Buy Sialic Acid - Nootropics - Next Valley
Buy Sialic Acid (N-Acetylneuraminic Acid) with a 30% stack discount from €20.55 /60 capsules. Next Valley supplies High Quality Sialic Acid with a Certificate of Analysis
16:10
I have steadily been increasing the dosage. Started with just 600mg and worked my way up to 2 grams.
16:13
Breast milk has been shown to contain high levels of sialic acid and there's been studies evaluating how the time period of breastfeeding effects infant IQ.
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Deleted User 13-Aug-22 04:13 PM
did u notice anything
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Potential 13-Aug-22 04:17 PM
Keep in mind that I've only been using it for a couple of days. But with that being said, I feel more alert for 2-3 hours after taking it and weirdly enough since taking it I have incorporated some small new things to my routine out of the blue. Pure optimization to already successful practises. Also light brain tingles.
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Deleted User
@ibtisam.midlet what's your chemical solution for heartbreak
ibtisam.midlet 13-Aug-22 06:31 PM
Anti empathy
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Deleted User
it's nice to be credited but making money off of someone else's idea is straight Edison BS
ibtisam.midlet 13-Aug-22 06:38 PM
There was a time where getting money from work is like getting it from bank
18:38
You did not tested the power of biology
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ibtisam.midlet
Click to see attachment 🖼️
Netizenne 13-Aug-22 10:20 PM
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Netizenne 13-Aug-22 10:35 PM
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Netizenne 13-Aug-22 11:38 PM
Would getting good consistent cardio balance out the working memory deficits of cannabis use??????
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Netizenne
Would getting good consistent cardio balance out the working memory deficits of cannabis use??????
Potential 14-Aug-22 12:36 AM
I don't think it would completely balance it but it would help. I have personally fixed a guy's brain from years of cannabis abuse. Improved his average grade by 2.
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MEE6 BOT 14-Aug-22 12:36 AM
GG @Potential, you just advanced to level 3!
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Netizenne
Would getting good consistent cardio balance out the working memory deficits of cannabis use??????
veganpermanently 14-Aug-22 12:57 AM
Not with concurrent use. If you stop consuming yes but you need to do as much as possible though you can do it at an easy pace. I recommend bike cycling because ligament and tendon injuries and insults are almost impossible to happen.
01:00
Also if you stop doing the exercise the deficits will quickly return. Benefits are best while exercising, which is why I recommend a stationary bike if you need it to do something on a computer. Otherwise normal bikes are better because of the mindfulness needed to pay attention to the road, this helps rebuild gray matter as well.
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Netizenne
I gotta find an evolutionary tree of g coupled protein receptors evolution
Netizenne 14-Aug-22 01:01 AM
https://www.researchgate.net/profile/Jan_Klomp/publication/51561494_Ss-TEA_Entropy_based_identification_of_receptor_specific_ligand_binding_residues_from_a_multiple_sequence_alignment_of_class_A_GPCRs/links/568baf1a08ae051f9afc5863/Ss-TEA-Entropy-based-identification-of-receptor-specific-ligand-binding-residues-from-a-multiple-sequence-alignment-of-class-A-GPCRs.pdf?origin=publication_detail
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Netizenne
https://www.researchgate.net/profile/Jan_Klomp/publication/51561494_Ss-TEA_Entropy_based_identification_of_receptor_specific_ligand_binding_residues_from_a_multiple_sequence_alignment_of_class_A_GPCRs/links/568baf1a08ae051f9afc5863/Ss-TEA-Entropy-based-identification-of-receptor-specific-ligand-binding-residues-from-a-multiple-sequence-alignment-of-class-A-GPCRs.pdf?origin=publication_detail
Netizenne 14-Aug-22 01:01 AM
The first figure is really cool
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ibtisam.midlet
Anti empathy
veganpermanently 14-Aug-22 01:01 AM
I meant homesick heartbreak, it doesn't work for this. I'm low empathy since 2015 or so
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Netizenne 14-Aug-22 01:02 AM
I’m gonna bring it into mspaint and make an annotated version for my notes
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Netizenne 14-Aug-22 01:09 AM
Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree
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01:09
Makes sense since they’re both very involved in hunger i guess
01:09
Stress too
01:09
Neat
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veganpermanently 14-Aug-22 01:10 AM
Memantine day
01:10
Alpha frequency
01:11
Translationary symmetry
01:11
Let's go motherfuckers.
01:12
Make small step for a man, large for mankind
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MEE6 BOT 14-Aug-22 01:12 AM
GG @veganpermanently, you just advanced to level 4!
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Netizenne
Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree
Netizenne 14-Aug-22 01:12 AM
GPR12, the one related to working memory, is also right there
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veganpermanently 14-Aug-22 01:12 AM
Dreams r on point
01:15
Listen to Water (Alpha 8Hz (Isochronic)) by DJ Taz Rashid on #SoundCloud https://soundcloud.app.goo.gl/84vAL
DJ Taz Rashid
Water (Alpha 8Hz (Isochronic))
DJ Taz Rashid (DJ TAZ) brings a high vibrational energy to any crowd instantly by mixing the beats and rhythms of Love, Ancient New World, Remixes, House, Kirtan, Devotional, and all the cosmic sounds
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01:15
Resting heart rate
01:15
Less than zero
01:16
Makes you feel like you don't even need to breathe anymore
01:16
🐸
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Deleted User 14-Aug-22 01:19 AM
@veganpermanently thought about what you said and I no longer think intelligence is just as simple as g factor
emoji_37 1
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veganpermanently
I meant homesick heartbreak, it doesn't work for this. I'm low empathy since 2015 or so
ibtisam.midlet 14-Aug-22 01:28 AM
when I'm very low in empathy (anafranil withdrawal) I don't have any type of it and completely empathy none responsive, but anyway blocking serotonin will harm you more then benefit you, it rarely act as depressant
01:29
dopamine 3 would greatly help
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Deleted User
@veganpermanently thought about what you said and I no longer think intelligence is just as simple as g factor
veganpermanently 14-Aug-22 01:32 AM
Glad u opened your mind
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Netizenne
Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree
Netizenne 14-Aug-22 01:33 AM
An environment with excess resources becomes r-selected Lots of feeding = lots of breeding perhaps
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Deleted User 14-Aug-22 01:34 AM
The night before
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Netizenne
An environment with excess resources becomes r-selected Lots of feeding = lots of breeding perhaps
veganpermanently 14-Aug-22 01:34 AM
But only if it is still space restricted. I.e. mouse Utopia experiment
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ibtisam.midlet 14-Aug-22 01:35 AM
@Netizenne why your account don't show up, I want to see you super mod x_x
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Deleted User 14-Aug-22 01:35 AM
I found some old data showing a working memory test my psych professor administered to me. I thought I had found the perfect and most simplistic test. Yes it was only loosely correlated to Iq which probably isn't even the full picture
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ibtisam.midlet
@Netizenne why your account don't show up, I want to see you super mod x_x
Netizenne 14-Aug-22 01:36 AM
????? But I am!!!! D:
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Deleted User 14-Aug-22 01:36 AM
I guess then I'll redefine my goal as general cognitive enhancement in any possible fashion I can muster.
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Deleted User
I found some old data showing a working memory test my psych professor administered to me. I thought I had found the perfect and most simplistic test. Yes it was only loosely correlated to Iq which probably isn't even the full picture
veganpermanently 14-Aug-22 01:37 AM
Little steps 😅
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Deleted User 14-Aug-22 01:37 AM
I don't think I see Iq as one pure thing anymore
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Deleted User
I don't think I see Iq as one pure thing anymore
veganpermanently 14-Aug-22 01:37 AM
Nice
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Netizenne
????? But I am!!!! D:
ibtisam.midlet 14-Aug-22 01:37 AM
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Netizenne
Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree
Netizenne 14-Aug-22 01:39 AM
I am going to worship this tree I want to know it inside out It will be my axis mundi -what holds it all together (edited)
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ibtisam.midlet
Click to see attachment 🖼️
Netizenne 14-Aug-22 01:40 AM
Owh rip I am always invisible mode lol
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ibtisam.midlet
You did not tested the power of biology
Deleted User 14-Aug-22 01:40 AM
no one did. I'm on the trajectory
01:40
So I would probably aim to increase any of the following. When it comes to intelligence - long term memory - processing speed - working memory - implicit skill acquisition - general brain health - mental stamina (edited)
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MEE6 BOT 14-Aug-22 01:40 AM
GG @Deleted User, you just advanced to level 1!
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Deleted User
So I would probably aim to increase any of the following. When it comes to intelligence - long term memory - processing speed - working memory - implicit skill acquisition - general brain health - mental stamina (edited)
Deleted User 14-Aug-22 01:42 AM
discipline
01:43
That too
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Netizenne
Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree
Netizenne 14-Aug-22 01:45 AM
Holy crap those are also the sphingosine 1 phosphate receptors also crammed into that tiny branch along with MCR and endocanninoids!!!!! They’re all so closely related
01:46
Only thing I’m not familiar with on that branch is LPAR (edited)
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Netizenne
Holy crap those are also the sphingosine 1 phosphate receptors also crammed into that tiny branch along with MCR and endocanninoids!!!!! They’re all so closely related
Deleted User 14-Aug-22 01:47 AM
You are really into this
01:47
I wish I could join you
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Deleted User
You are really into this
Netizenne 14-Aug-22 01:48 AM
Treeeeeeeeeeesssss
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Deleted User
So I would probably aim to increase any of the following. When it comes to intelligence - long term memory - processing speed - working memory - implicit skill acquisition - general brain health - mental stamina (edited)
ibtisam.midlet 14-Aug-22 01:48 AM
Processing speed dopamine 1 , alpha 2 a adrenaline Mental stamina =dfo IN
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Netizenne 14-Aug-22 01:48 AM
The treeeees connect it allll
01:48
Web of wyrd
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Deleted User 14-Aug-22 01:49 AM
Maybe humans are just too evolved to get wm increases from dfo
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Deleted User
no one did. I'm on the trajectory
ibtisam.midlet 14-Aug-22 01:49 AM
Ask @abcd on MDMA and methylene blue
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Netizenne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226366/ Responsible for 17% of variance in working memory in mice and is agonized by sphingosine 1 phosphate ????? Also related to CB1 receptor. (edited)
Netizenne 14-Aug-22 01:49 AM
Jukesta did you see this orphan receptor we found?????
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ibtisam.midlet 14-Aug-22 01:50 AM
Or ask me on nmda-tune
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Netizenne 14-Aug-22 01:50 AM
It is right on that branch of the tree too
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Netizenne
Jukesta did you see this orphan receptor we found?????
Deleted User 14-Aug-22 01:50 AM
No what's it about
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Deleted User
No what's it about
Netizenne 14-Aug-22 01:51 AM
It’s responsible for a lot of genetic variance in working memory Highly implicated (edited)
01:51
It’s closely related to endocannabinoid receptors which are also known to mess with working memory (edited)
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Deleted User 14-Aug-22 01:52 AM
Mh
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Netizenne
Endocannibinoid receptors and Melanocortin receptors are on the same branch of the GCPR family tree
Netizenne 14-Aug-22 01:52 AM
Tree pic
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ibtisam.midlet 14-Aug-22 01:53 AM
There some impossibility you can find functional agonist that produce canabiniod effect and enhance memory
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Deleted User 14-Aug-22 01:53 AM
Cb1
emoji_37 1
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ibtisam.midlet
There some impossibility you can find functional agonist that produce canabiniod effect and enhance memory
Deleted User 14-Aug-22 01:53 AM
i did
confusion 1
01:53
What
01:55
there's multiple of these compounds in nature
01:55
I just need to isolate and produce large quantities
01:55
Thc?
01:55
will send you guys samples
Waow 1
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MEE6 BOT 14-Aug-22 01:55 AM
GG @Deleted User, you just advanced to level 2!
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Deleted User
Thc?
Deleted User 14-Aug-22 01:56 AM
no it's unrelated to cannabis
01:56
Urb 597?
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Netizenne 14-Aug-22 01:56 AM
We need to breed bacteria Or inject them with the dna to make the right enzymes
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Deleted User
Urb 597?
Deleted User 14-Aug-22 01:56 AM
noo
01:56
Well
01:56
So it's a cb1 receptor agonist?
01:57
not really, but it does have the same effects
01:57
Can you just say what it is?
01:57
no
01:57
that would cost me hundreds of thousands
despair 1
01:58
offfered this info for 0.5 btc
01:58
Well okay as long as I get a sample
01:58
now the price is 1 btc
emoji_52 1
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Deleted User
Well okay as long as I get a sample
Deleted User 14-Aug-22 01:58 AM
probably
01:58
Good enough
01:59
Continuing this topic I have noticed some interesting effects from high doses of weed in the past
01:59
I will first test it on myself
01:59
like any respectable biohacker
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Deleted User
Continuing this topic I have noticed some interesting effects from high doses of weed in the past
Deleted User 14-Aug-22 01:59 AM
I do high dose once a month
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Netizenne 14-Aug-22 01:59 AM
Idc about profit or getting high tbh I’m just curious at this point wtf despair despair despair despair despair despair despair
01:59
riiip
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Deleted User 14-Aug-22 01:59 AM
I don't consume it anymore other than that
02:00
I try to avoid it but
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Netizenne 14-Aug-22 02:00 AM
I can keep lip zeal 🤐🥺
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Deleted User 14-Aug-22 02:00 AM
I'll admit it has acutely exploded my ability to visualize in the past
02:00
this is Terrence Mckenna method but he was clueless about reward pathways and never had the willpower to do it like that as result
02:01
I have found ways to make me not have the desire to redose next day
02:01
but increases effects on the day of consumption
02:01
tomorrow is the day
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Deleted User
once youve weighed everytthing you take out for 2 years
blank 14-Aug-22 02:01 AM
Yeah tbh I've been weighing stuff for about a month now and more often than not get it within a few mg of the target weight in the first measurement
02:01
I was stuck reading some old messages 💀
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Deleted User
tomorrow is the day
Deleted User 14-Aug-22 02:02 AM
The day you get lit?
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Deleted User
The day you get lit?
Deleted User 14-Aug-22 02:02 AM
yes
02:02
Nice
02:02
every 15th of the month
02:02
I'll probably use lsd soon
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blank 14-Aug-22 02:02 AM
What about oleamide for cb1?
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blank
What about oleamide for cb1?
Deleted User 14-Aug-22 02:02 AM
that will impair cognition
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blank 14-Aug-22 02:02 AM
I think it was also 5ht2c antagonist and maybe something
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Deleted User
that will impair cognition
blank 14-Aug-22 02:02 AM
Prolly
02:02
What's this CB receptor talk
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Deleted User 14-Aug-22 02:03 AM
Apparently cb1 is related to variance in wm
02:03
Which I'm actually inclined to believe based on my experience with cannabis
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Netizenne 14-Aug-22 02:04 AM
Tyrosine kinase family tree https://www.frontiersin.org/articles/10.3389/fendo.2013.00193/full
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Frontiers | Phylogenetic Investigation of Peptide Hormone and Growt...
Peptide hormones and growth factors bind to membrane receptors and regulate a myriad of processes in insects and other metazoans. The evolutionary relationships among characterized and un-characterized (“orphan”) receptors can provide insights into receptor-ligand biology and narrow target choices in deorphanization studies. However, the large n...
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Deleted User
Apparently cb1 is related to variance in wm
Deleted User 14-Aug-22 02:05 AM
in a perfect world we don't need cb1 agonism
02:05
but the world is very polluted
02:06
Do you know anything about urb 597
02:06
so if you go live on a mountain at say 1-2000 m elevation you will be clearheaded all the time
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Deleted User
Do you know anything about urb 597
Deleted User 14-Aug-22 02:06 AM
yes FAAH inhibition sucks
02:07
Really and why's that @Deleted User
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Netizenne
Tyrosine kinase family tree https://www.frontiersin.org/articles/10.3389/fendo.2013.00193/full
Netizenne 14-Aug-22 02:10 AM
I think this tree includes non-human proteins :/
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Deleted User 14-Aug-22 02:10 AM
Urb 597 would supposedly upregulate cb1
02:10
As well as other things
02:10
And I've heard a rumor that it can induce lucid dreaming
02:10
I'd like to know more
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Netizenne
Tyrosine kinase family tree https://www.frontiersin.org/articles/10.3389/fendo.2013.00193/full
Netizenne 14-Aug-22 02:12 AM
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Deleted User 14-Aug-22 02:13 AM
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Deleted User
Click to see attachment 🖼️
Deleted User 14-Aug-22 02:13 AM
@Netizenne thoughts?
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Deleted User
Which I'm actually inclined to believe based on my experience with cannabis
Netizenne 14-Aug-22 02:15 AM
Well it defiantly has been shown to decrease it after a while, so we atleast know it interacts with wm and that it has some role in the mechanisms of wm (edited)
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Netizenne
Well it defiantly has been shown to decrease it after a while, so we atleast know it interacts with wm and that it has some role in the mechanisms of wm (edited)
Deleted User 14-Aug-22 02:16 AM
What do you think about cb1s relation to anxiety and motivation
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MEE6 BOT 14-Aug-22 02:16 AM
GG @Deleted User, you just advanced to level 3!
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Deleted User
Click to see attachment 🖼️
Deleted User 14-Aug-22 02:16 AM
I had same effects from high dose CBD
02:16
a bit less than a gram daily for a week (edited)
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Deleted User
What do you think about cb1s relation to anxiety and motivation
Netizenne 14-Aug-22 02:17 AM
Probably has some role modulating HPA axis It’s related to MCRs and also has obvious effects on stress Idk about motivation tho (edited)
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Deleted User 14-Aug-22 02:17 AM
made me not give a f about anything
02:17
very worrying state
02:18
So lets assume that cb1 upregulation would enhance wm. And taking urb 597 could be a means to achieve this. The lack of vigilance could be more of a downside then its worth
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Deleted User
What do you think about cb1s relation to anxiety and motivation
Netizenne 14-Aug-22 02:18 AM
Working memory is essential for the organization of goal-directed behavior, as it maintains task-relevant information.
I wrote this earlier in response to that quote:
Working memory holds information to direct goals as well as the information to accomplish those goals? It holds the check list and equation sheets to solve? So say your working memory is divided into 7 slots to hold information. If you have 5 goals instead of 1 does that limit how much free processing power you have to pursue those goals? (5 different classes in school) People with adhd or autism who have a specific interest, I feel like that occupies too much space in their mind at all times for them to focus. Or maybe not.
 (edited)
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MEE6 BOT 14-Aug-22 02:18 AM
GG @Netizenne, you just advanced to level 6!
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Deleted User
So lets assume that cb1 upregulation would enhance wm. And taking urb 597 could be a means to achieve this. The lack of vigilance could be more of a downside then its worth
blank 14-Aug-22 02:19 AM
Work capacity > IQ anyways
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Deleted User
So lets assume that cb1 upregulation would enhance wm. And taking urb 597 could be a means to achieve this. The lack of vigilance could be more of a downside then its worth
Deleted User 14-Aug-22 02:19 AM
indeed
02:20
it changes your personality
02:20
Have you taken?
02:20
I am usually a very worried person. I take care that I and everybody around me are safe
02:20
Hmm
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Deleted User
@Netizenne thoughts?
Netizenne 14-Aug-22 02:21 AM
I’ve never heard of Urb, looks interesting
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Deleted User 14-Aug-22 02:21 AM
but taking CBD completely removes this aspect of my personality
02:21
which is a detriment if you ask me
02:21
it would decrease intelligence by virtue of decreasing negative affect
02:22
Hyper vigilance is probably correlated to IQ
02:22
This is difficult
02:22
indeed
02:22
if I could I would upregulate FAAH
02:23
Really
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Deleted User
Hyper vigilance is probably correlated to IQ
Deleted User 14-Aug-22 02:23 AM
IQ is prerequisite to hypervigilance but hypervigilance is necessary to apply intelligence in everyday life
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blank 14-Aug-22 02:23 AM
What comes to mind when I think about vigilance is some 100 IQ go getter 😂
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Deleted User
So lets assume that cb1 upregulation would enhance wm. And taking urb 597 could be a means to achieve this. The lack of vigilance could be more of a downside then its worth
Netizenne 14-Aug-22 02:24 AM
CB1 agonism doesn’t acutely enhance wm does it????????????? I’ve read that it can reduce it up to 3 months after cessation though. (edited)
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Netizenne
CB1 agonism doesn’t acutely enhance wm does it????????????? I’ve read that it can reduce it up to 3 months after cessation though. (edited)
Deleted User 14-Aug-22 02:27 AM
Nvm I misresd the paper u sent
02:27
It was
02:27
Gpr12 (edited)
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Netizenne 14-Aug-22 02:27 AM
Check the one also linked directly above the one I posted
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Netizenne
Check the one also linked directly above the one I posted
Deleted User 14-Aug-22 02:28 AM
This was mostly a misunderstanding
02:28
But
02:28
I'm still interested in cb1 and urb 597 (edited)
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Deleted User
I'm still interested in cb1 and urb 597 (edited)
Deleted User 14-Aug-22 02:32 AM
it's funny to think about these things (edited)
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Netizenne 14-Aug-22 02:33 AM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871916/
A primary function of the endocannabinoid signaling system is to maintain or recover homeostasis following psychological and physiological threats.
 (edited)
Endocannabinoid Signaling and the Hypothalamic-Pituitary-Adrenal Axis
The elucidation of Δ[9] -tetrahydrocannabinol as the active principal of Cannabis sativa in 1963 initiated a fruitful half-century of scientific discovery, culminating in the identification of the endocannabinoid signaling system, a previously ...
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02:33
More HPA loreeeeeeeeeee HPA is core (edited)
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Deleted User 14-Aug-22 02:33 AM
Image attachment
02:34
plenty of paradoxes when it comes to this.
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Netizenne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871916/
A primary function of the endocannabinoid signaling system is to maintain or recover homeostasis following psychological and physiological threats.
 (edited)
Netizenne 14-Aug-22 02:35 AM
This part is especially interesting
We discuss recent findings that corticotropin-releasing hormone in the amygdala enables hypothalamic-pituitary-adrenal axis activation via an increase in the catabolism of the endocannabinoid N-arachidonylethanolamine.
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02:37
So the endogenous cannabinoid is constantly signalling to put the breaks on the HPA axis, and CRH activates it by increasing the breakdown of that endocannabinoid
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Deleted User 14-Aug-22 02:38 AM
https://www.youtube.com/watch?v=qQ_W1w9v-2Y
Mettaverse Music
Astral | Deep Theta 4Hz | Binaural Beats Soundscape | Internal Focu...
02:38
I might try urb 597
02:39
See if it does anything to wm
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Deleted User
See if it does anything to wm
Deleted User 14-Aug-22 02:42 AM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156972/
Pharmacological elevation of anandamide impairs short-term memory b...
In rodents, many exogenous cannabinoid agonists including Δ[9] -THC and WIN 55,212-2 (WIN-2) have been shown to impair short-term memory (STM) by inhibition of hippocampal neuronal assemblies. However, the mechanisms by which endocannabinoids ...
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Deleted User
I might try urb 597
blank 14-Aug-22 02:42 AM
it's cheap?
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veganpermanently 14-Aug-22 02:43 AM
Stupid ideas
02:43
Shortsighted
02:43
Devoid of lateral thought
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Deleted User
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156972/
Deleted User 14-Aug-22 02:44 AM
And nvm
02:45
Too bad there's no grp12 agonist
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Netizenne 14-Aug-22 02:45 AM
HPA axis controls stress and dealing with the problems causing our stress
02:46
elevated cortisol induced by stress increases serotonin uptake
💯 1
02:46
(2a) Serotonergic mindset is problem solving mode (edited)
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veganpermanently 14-Aug-22 02:46 AM
Wut
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Netizenne 14-Aug-22 02:46 AM
Imo
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veganpermanently 14-Aug-22 02:46 AM
How does that follow
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komodo dragon 14-Aug-22 02:47 AM
Hey how are you all
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veganpermanently 14-Aug-22 02:47 AM
Can u link study about 5ht uptake
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Deleted User 14-Aug-22 02:47 AM
This is madness
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Netizenne 14-Aug-22 02:47 AM
When I take psychedelics I feel like I can solve any problem, answer any question I feel capable of any and everything on psychedelics, like I’m at 1000% functioning
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komodo dragon
Hey how are you all
veganpermanently 14-Aug-22 02:47 AM
With a resting heart rate less than zero
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Netizenne
When I take psychedelics I feel like I can solve any problem, answer any question I feel capable of any and everything on psychedelics, like I’m at 1000% functioning
Netizenne 14-Aug-22 02:47 AM
Psychedelics made me feel like I was in problem solving mode
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Netizenne
When I take psychedelics I feel like I can solve any problem, answer any question I feel capable of any and everything on psychedelics, like I’m at 1000% functioning
Deleted User 14-Aug-22 02:48 AM
I don't know if you actually are able to
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veganpermanently
With a resting heart rate less than zero
komodo dragon 14-Aug-22 02:48 AM
You've transcended us all 😲
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Deleted User 14-Aug-22 02:49 AM
Psychs are known to make people think they are smarter than they are and see patterns where there isn't any
02:49
I agree it increases pattern recognition
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komodo dragon 14-Aug-22 02:49 AM
Just wanted to put this out here: I think PRL could interact with GPR139
02:49
That's all
02:49
I will disappear now.
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veganpermanently
How does that follow
Netizenne 14-Aug-22 02:50 AM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ Two ways of dealing with your problems: Active coping (problem solving) Passive coping (problem ignoring/accepting) Both are stress responses
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Serotonin and brain function: a tale of two receptors
Previous attempts to identify a unified theory of brain serotonin function have largely failed to achieve consensus. In this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the ...
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02:50
It’s a robin carhart harris theory
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veganpermanently
Can u link study about 5ht uptake
Netizenne 14-Aug-22 02:51 AM
https://pubmed.ncbi.nlm.nih.gov/12467107/ I could be wrong, just googled it and read what google said
Enhancement of serotonin uptake by cortisol: a possible link betwee...
Stress and depression are characterized by elevation of circulating cortisol, as well as by changes in physiological functions. In this study, we addressed the possibility that elevated cortisol is also associated with the origin and development of depression. We report here that cortisol at the nM- …
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komodo dragon
I will disappear now.
Netizenne 14-Aug-22 02:52 AM
boywave
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Netizenne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ Two ways of dealing with your problems: Active coping (problem solving) Passive coping (problem ignoring/accepting) Both are stress responses
Deleted User 14-Aug-22 02:52 AM
you're golden
Waow 2
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Netizenne 14-Aug-22 02:52 AM
Farewelllll
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Deleted User 14-Aug-22 02:53 AM
that pic
02:53
omg
02:53
my mind on a piece of paper
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Deleted User
you're golden
Netizenne 14-Aug-22 02:53 AM
JC Denton sent that study a while back 🙏 (edited)
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Netizenne
JC Denton sent that study a while back 🙏 (edited)
Deleted User 14-Aug-22 02:54 AM
that motherfucker
02:54
🙏
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Deleted User
that pic
Netizenne 14-Aug-22 02:54 AM
Imagine if you couldn't passively cope and felt forced to actively engage every arrogant idiot who ever annoyed you to reduce how much their existence bothers you lol …..I wouldn’t know xdddd withered (edited)
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Netizenne
Imagine if you couldn't passively cope and felt forced to actively engage every arrogant idiot who ever annoyed you to reduce how much their existence bothers you lol …..I wouldn’t know xdddd withered (edited)
Deleted User 14-Aug-22 02:55 AM
kek I'm close
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Netizenne 14-Aug-22 02:55 AM
There’s a place for both 1A and 2A
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Deleted User 14-Aug-22 02:56 AM
I heard 5meo dmt targets 5htp1a pretty well
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Deleted User
I heard 5meo dmt targets 5htp1a pretty well
Deleted User 14-Aug-22 02:56 AM
all classical psychs target it
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Netizenne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ Two ways of dealing with your problems: Active coping (problem solving) Passive coping (problem ignoring/accepting) Both are stress responses
Netizenne 14-Aug-22 02:57 AM
Also idk if you’ve watched neon genesis evangelion -but I think how shinji accepts the situation his father puts him in (passive cope) and just fights the robots (active cope) it demonstrates a lot how the two systems can work together synergistically. They aren’t necessarily opposing i think. (edited)
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Deleted User 14-Aug-22 02:57 AM
Meo seems mostly like 1a
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Mabus Tiefsee 14-Aug-22 02:57 AM
stupid question, how does the brain change when it goes from shugar metabolism to ketone metabolism.
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Netizenne
HPA axis controls stress and dealing with the problems causing our stress
Netizenne 14-Aug-22 03:00 AM
Does cannabis decrease serotonergic activity? (edited)
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Deleted User 14-Aug-22 03:01 AM
I'm not gonna lie mice wm studies seem like shit
03:02
Not entering the same room twice is basically the extent of mice wm testing
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Mabus Tiefsee 14-Aug-22 03:02 AM
all behaviour mice/rat studis that include male researcher are scewed anyway. They react way more stressed around male smell. And as a rat breeder i can confirm that (and used that behaviour multiple times)
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Deleted User 14-Aug-22 03:02 AM
I feel like that could include so much more than pure wn
03:03
Chimp studies would be a million times better since they can actually be taught wm games
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Netizenne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871916/
A primary function of the endocannabinoid signaling system is to maintain or recover homeostasis following psychological and physiological threats.
 (edited)
Netizenne 14-Aug-22 03:03 AM
cannabinoid receptor 1 (CB1R) signaling can both inhibit and potentiate the activation of the hypothalamic-pituitary-adrenal axis by stress tho
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Netizenne
cannabinoid receptor 1 (CB1R) signaling can both inhibit and potentiate the activation of the hypothalamic-pituitary-adrenal axis by stress tho
Deleted User 14-Aug-22 03:03 AM
Makes sense
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Netizenne 14-Aug-22 03:03 AM
It’s ofc more complex than first would seem despair (edited)
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MEE6 BOT 14-Aug-22 03:03 AM
GG @Deleted User, you just advanced to level 4!
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Netizenne
It’s ofc more complex than first would seem despair (edited)
Deleted User 14-Aug-22 03:03 AM
It's all brutally complex
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Netizenne
Does cannabis decrease serotonergic activity? (edited)
Deleted User 14-Aug-22 03:04 AM
no it increases it somehow
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Deleted User
It's all brutally complex
Netizenne 14-Aug-22 03:04 AM
Trees will organize for us Prayge
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Deleted User 14-Aug-22 03:04 AM
We need smarter drugs
03:04
5ht2a
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Netizenne 14-Aug-22 03:04 AM
Well I need sleep gnnnnnnnn
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Deleted User 14-Aug-22 03:04 AM
We need drugs that do more than agonism or pam
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Mabus Tiefsee 14-Aug-22 03:04 AM
and not all got the same amount of canabis receptors, i assume my amount is lower than the average (or somegow different in an other way?)
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Deleted User 14-Aug-22 03:05 AM
That actually have complex mechanisms
03:06
Like imagine drugs that would upregulate gamma wave activity directly
03:10
Tbh I'm just gonna try out my plans when it comes to cognitive enhancement.
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komodo dragon 14-Aug-22 03:13 AM
Jukesta I believe in you
03:13
@Deleted User is nitraria komarovii worth pursuing or nah
03:14
iyo
03:14
For all ik it could be recreationally, hallucinogenic or whatever
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komodo dragon
@Deleted User is nitraria komarovii worth pursuing or nah
Deleted User 14-Aug-22 03:17 AM
if u can get viable seeds yes
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Netizenne 14-Aug-22 03:18 AM
03:18
Gnnnnnnnn chattt!!!!!!!!!!!!!!!!!!
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Netizenne
Click to see attachment 🖼️
ibtisam.midlet 14-Aug-22 03:19 AM
Where the video that you look like on MDMA buzz
03:19
emoji_1
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ibtisam.midlet
Where the video that you look like on MDMA buzz
Deleted User 14-Aug-22 03:27 AM
need nitro to upload it xD
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Netizenne
Click to see attachment 🖼️
Deleted User 14-Aug-22 03:27 AM
@ibtisam.midlet yo
03:28
Image attachment
03:29
toad king out. about to merge with my swamp
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Netizenne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ Two ways of dealing with your problems: Active coping (problem solving) Passive coping (problem ignoring/accepting) Both are stress responses
Deleted User 14-Aug-22 04:45 AM
u know Neti... 5HT1A has many problems. Nooking 5HT2A is one of them
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Deleted User 14-Aug-22 05:00 AM
they're opposing forces. life can either be easy, stuff gets put under the rug, or it can be hard, yet better by the day
05:00
second law of thermodynamics
05:00
whatever doesn't improve will get worse
05:01
so 5HT1A is an evil receptor
05:03
it is C.O.P.E.
05:03
/cancerous obedient people externalizing
05:07
We need to connect the TAFFA /thoughts actions feelings facts associations/ to gain the holy trinity of I /intuition intention intervention/, master the MAD /meaning aspiration dedication/ LAD /liberty alternation discipline/, defeat the DAD /distractions addictions delusions/ and finally, above all, complete the MISSION /mapping investigation structure superintendence infrastructure operation naturalization/.
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Deleted User 14-Aug-22 05:39 AM
https://www.reddit.com/r/gvane/comments/wo5eqp/enhanced_human/
r/gvane - Enhanced Human
0 votes and 0 comments so far on Reddit
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ibtisam.midlet 14-Aug-22 07:06 AM
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Deleted User 14-Aug-22 07:20 AM
Why lol
💀 2
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ibtisam.midlet
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Potential 14-Aug-22 07:25 AM
Hot.
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Deleted User
/cancerous obedient people externalizing
Yana 14-Aug-22 07:26 AM
The C.O.N.S.P.I.R.A.C.Y., short for Cliques Of Normals Secretly Planning Insidious Rituals Aimed at Controlling You
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REAL 1
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Deleted User
they're opposing forces. life can either be easy, stuff gets put under the rug, or it can be hard, yet better by the day
Yana 14-Aug-22 07:27 AM
This is an interesting way of putting it
07:27
Is this why DMT can be so scary
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Deleted User
Why lol
Deleted User 14-Aug-22 07:39 AM
to distract you from the MISSION
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Deleted User 14-Aug-22 09:09 AM
😆
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Deleted User
😆
Deleted User 14-Aug-22 09:09 AM
https://www.youtube.com/watch?v=UNKZb2cVZZw
ElWosky
STAY FOCUS ft.Mario Bote
09:10
Thinking about my plan tbh
09:10
I haven't been set on actions
09:12
https://soundcloud.com/jeremychknsht/temporary @Netizenne
Lafew
temporary
Listen to temporary by Lafew #np on #SoundCloud
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09:12
Prob just gonna keep taking ha p6
09:12
fuck peptides
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komodo dragon 14-Aug-22 09:12 AM
why do you dislike peptides
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Deleted User 14-Aug-22 09:13 AM
because they always mimic endogenous peptides or proteins
09:13
Most of the noots I have are acute
09:13
this makes them dangerous because the body can develop antibodies
09:13
it can do so for small molecules as well, but in that case you just stop taking the drug
09:14
in the case of the peptide you can't stop taking it because you're producing it
emoji_37 1
09:14
I take it infrequently
09:14
I think it might have improved my vision
09:14
secondly, peptides are never orally active which is the safest RoA other than transdermal
09:15
because of infections mainly
09:15
but also it's easier to administer
09:15
Hm
09:15
they're also never active sublingually unless it's just a dipeptide
09:15
I've fought about that
09:15
I use the same syringe every time I take it although I wash with hot water first
09:15
buccally too
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komodo dragon 14-Aug-22 09:15 AM
Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death https://pubmed.ncbi.nlm.nih.gov/30684217/ Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506974/ Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217549/ NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder https://pubmed.ncbi.nlm.nih.gov/29770430/ Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder https://pubmed.ncbi.nlm.nih.gov/15635701/ NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570679/ Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364372/ Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645690/ Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925045/ Epinephrine Released During Traumatic Events May Strengthen Contextual Fear Memory Through Increased Hippocampus mRNA Expression of Nr4a Transcription Factors https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167477/ A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631643/ Pharmacological activation of Nr4a rescues age-associated memory decline https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917472/ @Deleted User
Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neurop...
NR4A2 is a nuclear receptor and a transcription factor, with distinctive physiological features. In the cell nuclei of the central nervous system, it is widely expressed and identified as a crucial regulator of dopaminergic (DA) neuronal differentiation, survival, and maintenance. Importantly, it ha …
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Differential roles for Nr4a1 and Nr4a2 in object location vs. objec...
Nr4a1 and Nr4a2 are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to block expression ...
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Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dop...
Dopaminergic neurons form in diverse areas of the vertebrate di- and mesencephalon to constitute several major neuromodulatory systems. While much is known about mammalian mesencephalic dopaminergic neuron development, little is known about the specification ...
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NR4A2 haploinsufficiency is associated with intellectual disability...
NR4A2, a member of the nuclear receptor superfamily, is involved in modulation of target gene transcription, regulating several developmental processes such as regulation of cellular homeostasis, neuronal development, inflammation and carcinogenesis. 2q24.1 deletions are extremely rare, and only 1 p …
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Identification and characterization of human NR4A2 polymorphisms in...
Attention deficit hyperactivity disorder (ADHD) is a highly heritable and common disorder thought to arise, in part, from alterations in dopamine function. NR4A2, or Nurr1, is an orphan nuclear receptor implicated in the development of dopaminergic cells of the ventral tegmental area (VTA) and the s …
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09:16
Development and Differentiation of Midbrain Dopaminergic Neuron: From Bench to Bedside https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349799/ Failure of Glial Cell-Line Derived Neurotrophic Factor (GDNF) in Clinical Trials Orchestrated By Reduced NR4A2 (NURR1) Transcription Factor in Parkinson’s Disease. A Systematic Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943926/ NR4A Transcription Factor Family: Key Regulators of Memory Formation https://cdn.discordapp.com/attachments/962009752488013834/1008362881634533386/296498079.pdf (thanks blank ❤️) potential pro-oncogene (or not, varies on a case-by-case basis): https://pubmed.ncbi.nlm.nih.gov/22566377/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864866/
Development and Differentiation of Midbrain Dopaminergic Neuron: Fr...
Parkinson’s Disease (PD) is a neurodegenerative disorder affecting the motor system. It is primarily due to substantial loss of midbrain dopamine (mDA) neurons in the substantia nigra pars compacta and to decreased innervation to the striatum. ...
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Failure of Glial Cell-Line Derived Neurotrophic Factor (GDNF) in Cl...
Parkinson’s disease (PD) is one of the most common neurodegenerative maladies with unforeseen complex pathologies. While this neurodegenerative disorder’s neuropathology is reasonably well known, its etiology remains a mystery, making ...
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Molecular pathways: the role of NR4A orphan nuclear receptors in ca...
Nuclear receptors are of integral importance in carcinogenesis. Manipulation of classic ligand-activated nuclear receptors, such as estrogen receptor blockade in breast cancer, is an important established cancer therapy. Orphan nuclear receptors, such as nuclear family 4 subgroup A (NR4A) receptors, …
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The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer
The three-orphan nuclear receptor 4A genes are induced by diverse stressors and stimuli, and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1) and NR4A3 (Nor1) play an important role in maintaining cellular homeostasis and in pathophysiology. ...
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09:16
wys
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Deleted User 14-Aug-22 09:16 AM
Wtf
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komodo dragon
Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death https://pubmed.ncbi.nlm.nih.gov/30684217/ Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506974/ Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217549/ NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder https://pubmed.ncbi.nlm.nih.gov/29770430/ Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder https://pubmed.ncbi.nlm.nih.gov/15635701/ NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570679/ Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364372/ Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645690/ Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925045/ Epinephrine Released During Traumatic Events May Strengthen Contextual Fear Memory Through Increased Hippocampus mRNA Expression of Nr4a Transcription Factors https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167477/ A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631643/ Pharmacological activation of Nr4a rescues age-associated memory decline https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917472/ @Deleted User
Deleted User 14-Aug-22 09:16 AM
dude
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komodo dragon 14-Aug-22 09:16 AM
im a nr4a goon
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Deleted User 14-Aug-22 09:16 AM
I have no attention span rn
09:16
dosed memantine
09:16
Chlo
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komodo dragon 14-Aug-22 09:16 AM
wait i have something that will give u the attention span
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komodo dragon
wait i have something that will give u the attention span
Deleted User 14-Aug-22 09:16 AM
it will come back in a few days
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komodo dragon 14-Aug-22 09:16 AM
itll make ur snake pent up. (edited)
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Deleted User 14-Aug-22 09:16 AM
I did this on purpose
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komodo dragon 14-Aug-22 09:17 AM
Overexpression of Nurr1 up-regulates Pitx3, TH and Vmat2 mRNAs
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komodo dragon
Overexpression of Nurr1 up-regulates Pitx3, TH and Vmat2 mRNAs
Deleted User 14-Aug-22 09:17 AM
I know about Nurr1
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MEE6 BOT 14-Aug-22 09:17 AM
GG @Deleted User, you just advanced to level 13!
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komodo dragon 14-Aug-22 09:17 AM
nr4a = nurr1
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Deleted User 14-Aug-22 09:17 AM
why you talking to me like I'm some noob 😛
09:17
These are the drugs I'm eye balling: Ara 290 IN Insulin Clemastine Phosphitidylserine
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komodo dragon 14-Aug-22 09:17 AM
D:
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Deleted User 14-Aug-22 09:17 AM
Thoughts?
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komodo dragon 14-Aug-22 09:17 AM
seems good
09:18
i believe in u jukesta.
09:18
take clemastine close to bed though
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Deleted User 14-Aug-22 09:18 AM
Nurr1 is a good thing
09:18
do u have agonist?
09:18
Nook it roflmao
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komodo dragon 14-Aug-22 09:18 AM
chloroquine
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Deleted User
Nook it roflmao
komodo dragon 14-Aug-22 09:19 AM
why
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komodo dragon
why
Deleted User 14-Aug-22 09:19 AM
nookin has suddenly got a whole new meaning
09:19
Nurr1 agonist nooks it
09:19
Ara 290 to unregulate epo Insulin which probably has a myriad of benefits Clemastine apparently myelinates the occular nerve Phosphatidylserine for myelination
09:19
and antagonist stops the explosion 😛
09:19
Also rapamycin
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Deleted User
Ara 290 to unregulate epo Insulin which probably has a myriad of benefits Clemastine apparently myelinates the occular nerve Phosphatidylserine for myelination
Deleted User 14-Aug-22 09:20 AM
u putting it all in your eyes or wut
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Deleted User
and antagonist stops the explosion 😛
komodo dragon 14-Aug-22 09:20 AM
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MEE6 BOT 14-Aug-22 09:20 AM
GG @komodo dragon, you just advanced to level 3!
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Deleted User 14-Aug-22 09:20 AM
Which due to autophagy should help with synaptic pruning and de-noising my brain
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Deleted User
u putting it all in your eyes or wut
Deleted User 14-Aug-22 09:20 AM
I want better vision
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Deleted User
I want better vision
Deleted User 14-Aug-22 09:20 AM
did u try CDPC
09:20
I think my brain is noisy right now from neurogenics
09:20
it improved my vision substantially
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Deleted User
did u try CDPC
Deleted User 14-Aug-22 09:20 AM
Nope havent
09:20
Tropoflavin as well
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Deleted User
I think my brain is noisy right now from neurogenics
Deleted User 14-Aug-22 09:21 AM
you've accumulated too much chloride
09:21
go ride a bike
09:21
for a few hours
09:21
you'll feel better
09:21
Chloride?
09:21
From what?
09:21
also NMDA antagonist will help
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Deleted User
From what?
Deleted User 14-Aug-22 09:21 AM
from exogenously evoked BDNF
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Deleted User
go ride a bike
Deleted User 14-Aug-22 09:22 AM
Was just about to ride a bike actually
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Deleted User
from exogenously evoked BDNF
Deleted User 14-Aug-22 09:22 AM
Really
09:22
the neurons start piling chloride
09:22
exercise-induced BDNF gets rid of this chloride accumulation
09:22
it has differential effects
09:23
When doing digit span I notice harder time reading and more noise than I used to
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Deleted User
also NMDA antagonist will help
judas 14-Aug-22 09:23 AM
Other than NMDA antags is there anything else you can use
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Deleted User 14-Aug-22 09:23 AM
Yea I've been wanting to exercise more
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judas
Other than NMDA antags is there anything else you can use
Deleted User 14-Aug-22 09:23 AM
bromides but I don't recommend this you will fuck yourself permanently from it
09:23
Exercise seems to be the most cognitively enhancing thing for me
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Deleted User
it has differential effects
Yana 14-Aug-22 09:23 AM
wtf
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Deleted User
bromides but I don't recommend this you will fuck yourself permanently from it
Deleted User 14-Aug-22 09:24 AM
Thoughts on using rapamycin to de noise?
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Yana
wtf
Deleted User 14-Aug-22 09:24 AM
I don't get surprised by these things anymore. Exercise uses every single mechanism in the best possible way
09:24
I've been noticing an increase in autistic like symptoms
09:25
Noise and chaos agitates me more than it ever has
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Deleted User
Thoughts on using rapamycin to de noise?
Deleted User 14-Aug-22 09:25 AM
in my experience it only creates more noise
09:25
Really
09:25
I thing autophagy would help cut down on loose synapses
09:26
yes. but fasting + rapamycin restarts the whole thing. neurogenics have effects similar to the honeymoon period for a while after the fast
09:26
rapamycin alone just creates a whole lot of confusion
09:26
Restarts?
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MEE6 BOT 14-Aug-22 09:26 AM
GG @Deleted User, you just advanced to level 5!
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Deleted User 14-Aug-22 09:26 AM
Wdym by that
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komodo dragon
Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death https://pubmed.ncbi.nlm.nih.gov/30684217/ Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506974/ Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217549/ NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder https://pubmed.ncbi.nlm.nih.gov/29770430/ Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder https://pubmed.ncbi.nlm.nih.gov/15635701/ NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570679/ Association Between NR4A2 Gene Polymorphism and Depressive Symptoms and Antidepressant Effect https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364372/ Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645690/ Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925045/ Epinephrine Released During Traumatic Events May Strengthen Contextual Fear Memory Through Increased Hippocampus mRNA Expression of Nr4a Transcription Factors https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167477/ A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631643/ Pharmacological activation of Nr4a rescues age-associated memory decline https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917472/ @Deleted User
Deleted User 14-Aug-22 09:27 AM
pls remind me if I forget I'll review this in a few days
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Deleted User
Restarts?
Deleted User 14-Aug-22 09:27 AM
I just explained lol
09:27
it's like taking neurogenics for the first time
09:27
similar
09:27
Oh
09:27
Wtf why
09:28
I guess it is effective at cutting the noise
09:28
but it does give me a headache
09:28
the day I take Rapa
09:28
I take it on day 3 of the fast
09:28
Dose?
09:28
when AMPK is the highest
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Deleted User
Dose?
Deleted User 14-Aug-22 09:28 AM
4-6 mg oral
09:28
Oh
09:29
capsulated
09:29
I assumed you would use IN
09:29
no
09:29
I'm not Pax
09:29
and I don't advocate that
09:29
Isn't oral rapa more systemic?
09:29
it's just a meme
09:29
In rapa?
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Deleted User
Isn't oral rapa more systemic?
Deleted User 14-Aug-22 09:29 AM
yes
09:29
I know that drugs taken IN target the brain better
09:30
but it is unknown what is the difference
09:30
For the most part
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Deleted User
but it is unknown what is the difference
Deleted User 14-Aug-22 09:39 AM
What's your opinion on pax
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Deleted User
What's your opinion on pax
Deleted User 14-Aug-22 09:40 AM
I have not talked to him for a long time
09:40
Like it's true that he can be sporadic but he did what pretty much everyone in the nootropic community does
09:40
last time I heard from him he sent me a voice recording yelling at me for 2 mins straight
emoji_13 1
09:41
He did his research he found some things that hypothetically would increase cognition
09:41
And yet those things did not increase cognition
09:41
Namely dfo
09:42
By all means dfo should have worked
09:42
It had lots of promise
09:42
Yet it didn't live up to the hype
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Mabus Tiefsee 14-Aug-22 09:43 AM
the main problem with brain abilitys, the amount you can increase is limited. You can't turn an idiot into a genious (maybe transhumanists can do that sometime with brainimplants combined with AI)
09:44
same with lifespan. You may be able to get 10-50 extra years, but that's it
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Deleted User
He did his research he found some things that hypothetically would increase cognition
Deleted User 14-Aug-22 09:44 AM
He tries to find fringe substances no one else used and use them to increase cognition according to his holistic understanding of the brain
09:45
This is similar to my approach, except I don't use substances that may cripple me in some way
DiosaSkull 1
09:45
True but you have to admit dfo had alot of research
09:45
First and foremost I look for substances that already have human or at least animal research behind them
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Deleted User
This is similar to my approach, except I don't use substances that may cripple me in some way
Mabus Tiefsee 14-Aug-22 09:45 AM
no risk no fun, i use carcinogenes
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Mabus Tiefsee
no risk no fun, i use carcinogenes
Deleted User 14-Aug-22 09:46 AM
this is a very irresponsible thing to say in this space
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Mabus Tiefsee
no risk no fun, i use carcinogenes
Deleted User 14-Aug-22 09:46 AM
Lol
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Mabus Tiefsee 14-Aug-22 09:46 AM
should i lie about the carcinogen abillity of igf1 and vit b3? it's a tradeoff
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Deleted User 14-Aug-22 09:46 AM
I am like a golden mean of Sirsad and Pax, one of them has no holistic understanding, while the other applies no risk management
😂 2
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Yana 14-Aug-22 09:47 AM
b3 lol how
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Mabus Tiefsee
should i lie about the carcinogen abillity of igf1 and vit b3? it's a tradeoff
Deleted User 14-Aug-22 09:47 AM
that's not what I meant
09:47
'no risk no fun'
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Mabus Tiefsee 14-Aug-22 09:47 AM
ah yeah, that part
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Yana 14-Aug-22 09:47 AM
Inhibiting FAO and SIRT is anti cancer
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Deleted User 14-Aug-22 09:48 AM
we need to strive to prevent risk at every cost
09:48
because that will make us go further
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Mabus Tiefsee 14-Aug-22 09:48 AM
sirt reminds me, i should eat some of my shugar limited wild cherrys again... taste good and healtgy
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Mabus Tiefsee
sirt reminds me, i should eat some of my shugar limited wild cherrys again... taste good and healtgy
Deleted User 14-Aug-22 09:49 AM
dude where r u
09:49
long gone cherry season here
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ibtisam.midlet
Click to see attachment 🖼️
Deleted User 14-Aug-22 09:49 AM
https://soundcloud.com/prrrrrrr-records/cam-hands-good-ass
Prrrrrrr
Cam & Hands - Good Ass
[PRR013] - support the artist: prrrrrrr.bandcamp.com/album/good-ass-ep produced by @cam-hands mastered by Precise Mastering coverart by @kaya-moody
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Deleted User
we need to strive to prevent risk at every cost
Mabus Tiefsee 14-Aug-22 09:50 AM
my mindset is different, wevhave to educate on tge tradeoffs; you wabt biger musckes and a longer dong? No problem HOWEVER your cancer risk will increase and you will suffer the following list of symptoms (insert agromegaly description)
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Mabus Tiefsee
my mindset is different, wevhave to educate on tge tradeoffs; you wabt biger musckes and a longer dong? No problem HOWEVER your cancer risk will increase and you will suffer the following list of symptoms (insert agromegaly description)
Deleted User 14-Aug-22 09:50 AM
I have ways to grow muscle without cancer risk
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Deleted User
dude where r u
Mabus Tiefsee 14-Aug-22 09:51 AM
made jam without shugar, the substances won't be destroyed if not heated above 120 (or something like that)
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Deleted User 14-Aug-22 09:51 AM
u know
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Mabus Tiefsee 14-Aug-22 09:51 AM
tried that, got to low natural backgroubd igf1 in my body
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Deleted User 14-Aug-22 09:51 AM
if you find me a piece of evidence showing exercise causes cancer I'll give up everything to your approach
09:52
yet it increases IGF1
09:52
yet it grows muscle
09:52
but this is just an example
09:52
so many interventions that grow muscle yet decrease cancer risk
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Mabus Tiefsee 14-Aug-22 09:53 AM
exercuse does not cause cancer but it is low, tidious and bot everybody can get the same results based on their genetics
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Deleted User 14-Aug-22 09:53 AM
time and tissue selectivity of interventions is key
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Mabus Tiefsee 14-Aug-22 09:54 AM
and to see the cancer risk, i give my 17 year old cat calf liver, she loves it, it prevents muscledystrophy and i will see how big the cancer risk is truly.
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Mabus Tiefsee
exercuse does not cause cancer but it is low, tidious and bot everybody can get the same results based on their genetics
Deleted User 14-Aug-22 09:54 AM
I don't mind the work
09:54
I have time because of the antiaging interventions
09:54
I have willpower because of the cognitive enhancement
09:54
so why not
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Mabus Tiefsee 14-Aug-22 09:55 AM
it all started because i wabted to grow my cheekbones/chin. That failed/was to slow however the musclegrowth is excelent. GH gut was a problem because of training problems
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Yana 14-Aug-22 09:57 AM
Liver fr gave you acormegaly and GH gut?
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Yana
Liver fr gave you acormegaly and GH gut?
Deleted User 14-Aug-22 09:58 AM
plot twist: the BCAA excess gave him visceral fat
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Mabus Tiefsee 14-Aug-22 09:58 AM
acromegaly simptoms. And the GH gut just started to apear once i trained my abs. It disapeared when i trained the inner abs (vaccum is the training method that helps)
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Mabus Tiefsee
acromegaly simptoms. And the GH gut just started to apear once i trained my abs. It disapeared when i trained the inner abs (vaccum is the training method that helps)
Deleted User 14-Aug-22 09:59 AM
how old r u
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Mabus Tiefsee 14-Aug-22 09:59 AM
over 30
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Deleted User
plot twist: the BCAA excess gave him visceral fat
Yana 14-Aug-22 09:59 AM
BCAA doesn't make your hands grow from M to XL
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Deleted User 14-Aug-22 09:59 AM
https://www.youtube.com/watch?v=FKyfvGCSQFA
This Never Happened
Lane 8 - Watermelon Wormhole
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Yana
BCAA doesn't make your hands grow from M to XL
Deleted User 14-Aug-22 09:59 AM
tru
09:59
🍉
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Yana
BCAA doesn't make your hands grow from M to XL
Deleted User 14-Aug-22 10:00 AM
we'll just call it the weird growth action
10:00
and attribute it to an unknown force we'll look for later
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Yana
BCAA doesn't make your hands grow from M to XL
Mabus Tiefsee 14-Aug-22 10:01 AM
just temporary XL for a month. Before that easy to wear M gloves. After they shrunk back (little swollen) tgey where barely L but the gloves didn't break anymore therefore L
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Mabus Tiefsee
just temporary XL for a month. Before that easy to wear M gloves. After they shrunk back (little swollen) tgey where barely L but the gloves didn't break anymore therefore L
Deleted User 14-Aug-22 10:02 AM
bone growth cannot revert
10:02
what you had was water retention from the inflammation
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Deleted User
bone growth cannot revert
Mabus Tiefsee 14-Aug-22 10:04 AM
XL was partyally because the tissue grew/swollen (happend in my face as well) and the bonegrowth was slower than the tissue growth. And yes, not reversable. Still size L hands. And i assume if i had more calcium in my diet, the bones could have grown further. But that's just an asumption
10:06
Before that i fit easily in site M gloves. Now i fit barely in size L and rip apart size M gloves (edited)
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komodo dragon 14-Aug-22 10:06 AM
https://www.pnas.org/doi/abs/10.1073/pnas.1902490116 👀
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
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Mabus Tiefsee 14-Aug-22 10:08 AM
oh by the way i was on a strict carnivore diet during that time. Therefore the glucose intake was one bar of chokolate a week or nothing. (edited)
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Mabus Tiefsee 14-Aug-22 10:16 AM
no matter what it was, it was direktly after eating 2,5 kg raw calf liver. And the symptoms matched IGF1 overexpression sideeffects.
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Deleted User
I am like a golden mean of Sirsad and Pax, one of them has no holistic understanding, while the other applies no risk management
ibtisam.midlet 14-Aug-22 10:20 AM
Combine considerable impulsivity and smartness with curiosity and you will solve everything
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Deleted User 14-Aug-22 10:23 AM
You just described me
emoji_8 1
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ibtisam.midlet
Combine considerable impulsivity and smartness with curiosity and you will solve everything
Potential 14-Aug-22 11:06 AM
I lack the impulsivity. Every move I make and the next 5 after that are meticulously calculated. This has brought me great success in life but has also hindered me in other ways.
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Potential
I lack the impulsivity. Every move I make and the next 5 after that are meticulously calculated. This has brought me great success in life but has also hindered me in other ways.
Mabus Tiefsee 14-Aug-22 11:07 AM
i was like that once, too. With age comes the attitude "just du stuff and see what happens"
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komodo dragon
https://www.pnas.org/doi/abs/10.1073/pnas.1902490116 👀
Deleted User 14-Aug-22 11:10 AM
I've used a dirty Nurr1 agonist that paradoxically reduced dopamine availability
11:10
it was hell
11:11
zero motivation until it was completely gone from my organism. recovered with modafinil
11:11
if u know a selective agonist let's go
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Mabus Tiefsee 14-Aug-22 11:12 AM
what gives me motivation to do stuff, but i don't want to do it. Removing my smartphone. I assume it is way to efficient in removing bordom for my own good...
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Mabus Tiefsee
what gives me motivation to do stuff, but i don't want to do it. Removing my smartphone. I assume it is way to efficient in removing bordom for my own good...
Deleted User 14-Aug-22 11:14 AM
tried that
11:14
with an antipsychotic removing stimuli will not help
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Mabus Tiefsee 14-Aug-22 11:15 AM
i assume at this point, your brain became an abnormallity anyway (if you where born with a normal one?) and therefore everything has to be discovered for your specific one anyway
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Mabus Tiefsee
i assume at this point, your brain became an abnormallity anyway (if you where born with a normal one?) and therefore everything has to be discovered for your specific one anyway
Deleted User 14-Aug-22 11:16 AM
one more person not to talk to ig
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Deleted User
Dose?
Netizenne 14-Aug-22 11:16 AM
They made a long detailed post a while back in this channel you should look for
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Deleted User 14-Aug-22 11:17 AM
https://www.youtube.com/watch?v=qvqWzlc16nA
Nora En Pure
Nora En Pure | Arnensee, Switzerland
11:17
let's go motherfuckers
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Deleted User
plot twist: the BCAA excess gave him visceral fat
Netizenne 14-Aug-22 11:22 AM
There is BCAAs in my creatine :/ I don’t eat that many per day, is it really that bad…??
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Netizenne
There is BCAAs in my creatine :/ I don’t eat that many per day, is it really that bad…??
Deleted User 14-Aug-22 11:24 AM
in my experience using 10 g leucine and 4 g lysine for 2-3 weeks produced insulin resistance and gave me visceral fat which was hard to get rid of
11:24
I did not have visceral since I was 14 yrs old so that was out of ordinary
11:26
https://www.jneurosci.org/content/40/18/3675 @komodo dragon unexpected results may follow
Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Lev...
The transcription factor Nurr1 has been identified to be ectopically induced in the striatum of rodents expressing l-DOPA-induced dyskinesia (LID). In the present study, we sought to characterize Nurr1 as a causative factor in LID expression. We used rAAV2/5 to overexpress Nurr1 or GFP in the parkinsonian striatum of LID-resistant Lewis or LID-p...
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Deleted User
in my experience using 10 g leucine and 4 g lysine for 2-3 weeks produced insulin resistance and gave me visceral fat which was hard to get rid of
Mabus Tiefsee 14-Aug-22 11:26 AM
next time you want to lose fat in specific areas, increase the bloodflow there while you are hungry/in energy defency. The ways for increasing the bloodflow are using muscles in that area/massage/hitting that area with a flat hand/vibration/chilly cream With increased blood flow, the fat cells get priority to be used
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Netizenne
https://pubmed.ncbi.nlm.nih.gov/12467107/ I could be wrong, just googled it and read what google said
Netizenne 14-Aug-22 11:43 AM
Wait I actually didn’t understand what I was saying when I posted this.
11:44
I thought cortisol raised serotonin lmaoo
11:44
Whoops, embarrassing :/ I guess it still kinda makes sense tho lol (edited)
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Potential
I lack the impulsivity. Every move I make and the next 5 after that are meticulously calculated. This has brought me great success in life but has also hindered me in other ways.
ibtisam.midlet 14-Aug-22 11:55 AM
Impulsivity is more benfitical then harm
11:57
I found my self go to work in things without caring much about the stress Ill get evuantulay due to responsapility a started to work 24h a day which solved my unproductivity.
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Deleted User
I've used a dirty Nurr1 agonist that paradoxically reduced dopamine availability
komodo dragon 14-Aug-22 11:58 AM
whatd u use
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Deleted User 14-Aug-22 12:21 PM
Time to give up on increasing IQ and figure out how to turn people into anime girls
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komodo dragon
whatd u use
veganpermanently 14-Aug-22 12:28 PM
Doxycycline
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ibtisam.midlet
Impulsivity is more benfitical then harm
veganpermanently 14-Aug-22 12:30 PM
Mindfulness makes impulsivity safe. Mindless impulsivity will killya
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Deleted User
Time to give up on increasing IQ and figure out how to turn people into anime girls
Pax1l 14-Aug-22 12:41 PM
Simp
Awwwhhh 1
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Deleted User 14-Aug-22 12:49 PM
Nah it's domination
12:49
Turn ur homies into anime girls and make a harem
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veganpermanently 14-Aug-22 12:50 PM
Someone has been watching Andrew Tate
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Deleted User
I did not have visceral since I was 14 yrs old so that was out of ordinary
Netizenne 14-Aug-22 12:56 PM
I had no visceral till like a few months ago despair
12:56
it’s not much but now I’m spooked
12:56
I have to start exercising to stay in shape withered
12:57
it’s cause I’m 21 in a few days
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veganpermanently 14-Aug-22 12:57 PM
Do my FMD protocol
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Netizenne 14-Aug-22 12:58 PM
Reading about how fat cells never get removed once you’ve grown new ones was really spook Like once you fuck up and eat too much once, those fat cells are with you for life, and the only way to keep them from filling up from that point on is to exercise Wuhhhh
12:58
Ngl I’ve gotten away with eating pretty unhealthy and never exercising up until this point with no issue
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Netizenne
Reading about how fat cells never get removed once you’ve grown new ones was really spook Like once you fuck up and eat too much once, those fat cells are with you for life, and the only way to keep them from filling up from that point on is to exercise Wuhhhh
Alyen 14-Aug-22 12:59 PM
What? As in old fat is only burned after new fat is burned?
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MEE6 BOT 14-Aug-22 12:59 PM
GG @Alyen, you just advanced to level 1!
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Alyen
What? As in old fat is only burned after new fat is burned?
Netizenne 14-Aug-22 01:03 PM
When you lose weight your emptying fat cells of lipids. When you gain weight your filling them with lipids. And this is a massive over simplification (cause I don’t understand it too fully) but if your fat cells are already completely full with lipids and you have nowhere to store the new fat your eating, your body will build new fat cells to store the new weight in. And these new fat cells are permanent, can’t get rid of them. (edited)
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Netizenne
When you lose weight your emptying fat cells of lipids. When you gain weight your filling them with lipids. And this is a massive over simplification (cause I don’t understand it too fully) but if your fat cells are already completely full with lipids and you have nowhere to store the new fat your eating, your body will build new fat cells to store the new weight in. And these new fat cells are permanent, can’t get rid of them. (edited)
veganpermanently 14-Aug-22 01:11 PM
Fat cells can get huge, some researchers even think people have a fixed number of fat cells
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Deleted User 14-Aug-22 01:16 PM
@Netizenne visceral fat cells are the ones that get huge and this implicates the insulin resistance, inflammation and so forth. We can gain fat cells but those are the cool subQ ones.
13:17
I want to keep as much subQ fat as possible while still maintaining zero visceral fat. exposing subQ fat to cold turns it to something similar to brown fat or what I like to call metabolic fat.
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Netizenne
When you lose weight your emptying fat cells of lipids. When you gain weight your filling them with lipids. And this is a massive over simplification (cause I don’t understand it too fully) but if your fat cells are already completely full with lipids and you have nowhere to store the new fat your eating, your body will build new fat cells to store the new weight in. And these new fat cells are permanent, can’t get rid of them. (edited)
Alyen 14-Aug-22 01:18 PM
Am I retarded or can you not just lose weight to get rid of the fat cells
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Deleted User 14-Aug-22 01:18 PM
This kind of fat produces heat when stimulated by either cold or heat AND 5ht2a agonism
13:19
so it's fat that actually burns calories and keeps you insulin sensitive. Kind of like muscle
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Alyen 14-Aug-22 01:20 PM
Is that “brown fat”
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Alyen
Is that “brown fat”
Deleted User 14-Aug-22 01:20 PM
no, it's white fat that has turned brown
13:20
it's not the same tissue but it has the same effects
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Deleted User
no, it's white fat that has turned brown
Alyen 14-Aug-22 01:21 PM
So it is brown fat?
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Deleted User 14-Aug-22 01:22 PM
I keep forgetting I block people for a reason
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Netizenne
When you lose weight your emptying fat cells of lipids. When you gain weight your filling them with lipids. And this is a massive over simplification (cause I don’t understand it too fully) but if your fat cells are already completely full with lipids and you have nowhere to store the new fat your eating, your body will build new fat cells to store the new weight in. And these new fat cells are permanent, can’t get rid of them. (edited)
ibtisam.midlet 14-Aug-22 01:24 PM
Adipocyte size 0.1mm empty , 0.3mm full we are fucked
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Deleted User
I keep forgetting I block people for a reason
Alyen 14-Aug-22 01:24 PM
49_pepekek
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ibtisam.midlet
Adipocyte size 0.1mm empty , 0.3mm full we are fucked
ibtisam.midlet 14-Aug-22 01:26 PM
https://en.m.wikipedia.org/wiki/Adipocyte https://journals.physiology.org/doi/full/10.1152/ajpregu.00257.2017 (edited)
Adipocyte
Adipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipocytes are derived from mesenchymal stem cells which give rise to adipocytes through adipogenesis. In cell culture, adipocyte progenitors can also form osteoblasts, myocytes and other cell types. Ther...
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Netizenne 14-Aug-22 01:40 PM
Butterflies are outt
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Netizenne
Butterflies are outt
Deleted User 14-Aug-22 01:40 PM
hhmmm
13:41
I have trouble IDing Rosa species
13:41
rugosa came to mind when I saw that
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Netizenne 14-Aug-22 01:41 PM
Image attachment
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Deleted User 14-Aug-22 01:41 PM
it must be rugosa
13:41
take it
13:42
it is nootropic
13:42
not the butterfly but the plant
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ibtisam.midlet 14-Aug-22 01:42 PM
Did anyone mega dosed rediola
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Deleted User
not the butterfly but the plant
Netizenne 14-Aug-22 01:42 PM
Holyshig
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ibtisam.midlet
Did anyone mega dosed rediola
judas 14-Aug-22 01:42 PM
I’m curious as to what this would do
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Netizenne 14-Aug-22 01:42 PM
I could never!!!! looooool (edited)
13:43
Those butterflies don’t grow in factories y’know
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Deleted User 14-Aug-22 01:43 PM
my ex and I had a love triangle with a butterfly
Awwwhhh 1
13:43
he was magnificent
13:43
we fed the caterpillar and it turned into a butterfly
Love 1
13:43
and he didn't want to leave my ex
13:43
for 2 week
13:44
I was jelly
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Netizenne 14-Aug-22 01:44 PM
Pretty bugs
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MEE6 BOT 14-Aug-22 01:44 PM
GG @Netizenne, you just advanced to level 7!
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judas
I’m curious as to what this would do
ibtisam.midlet 14-Aug-22 01:44 PM
Excepted to be less side effect in dose to dose potency of wallbutrine
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Netizenne 14-Aug-22 01:45 PM
There’s alotta grasshoppers flying around lately They kinda remind me of tiny winged reptiles lmfao
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Netizenne
There’s alotta grasshoppers flying around lately They kinda remind me of tiny winged reptiles lmfao
Deleted User 14-Aug-22 01:45 PM
do you know those motherfuckers can smell cancer
👀 1
13:45
even better than dogs
13:45
and can tell diff types of cancer apart
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Netizenne 14-Aug-22 01:45 PM
How do I utilize that
13:46
Can I catch them and harness this power????????
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Deleted User 14-Aug-22 01:46 PM
no but someone is working on it
13:46
someone with more money and power than us
13:46
https://www.youtube.com/watch?v=JivNDRvdhpk
SΣLΣNNΣ
grimes - we appreciate power (slowed + reverb)
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Netizenne
Can I catch them and harness this power????????
Deleted User 14-Aug-22 01:51 PM
https://pubmed.ncbi.nlm.nih.gov/34719871/
Dietary citrate supplementation enhances longevity, metabolic healt...
Citrate is an essential substrate for energy metabolism that plays critical roles in regulating cell growth and survival. However, the action of citrate in regulating metabolism, cognition, and aging at the organismal level remains poorly understood. Here, we report that dietary supplementation with …
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🍋 1
13:51
yooooo
13:52
😄
13:52
you know where this goes
13:54
if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap. 🍋
13:54
🍋
🍉 3
lemonuwu 2
13:55
@komodo dragon motherfucker
13:55
if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap. 🍋
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komodo dragon 14-Aug-22 01:55 PM
if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap. 🍋
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Netizenne 14-Aug-22 03:23 PM
https://www.frontiersin.org/articles/10.3389/fnins.2020.00612/full This ALA I’ve been taking is an iron chelator Holyshig
Frontiers | Alpha-Lipoic Acid Mediates Clearance of Iron Accumulati...
Disruption of neuronal iron homeostasis and oxidative stress are related to the pathogenesis of Parkinson’s disease (PD). Alpha-lipoic acid (ALA), a naturally occurring enzyme cofactor with antioxidant and iron chelator properties, has many known effects. It is known that ALA has neuroprotective effects on PD, but its underlying mechanism remain...
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15:23
not sure I need DFO then????? (edited)
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Netizenne
not sure I need DFO then????? (edited)
Deleted User 14-Aug-22 03:23 PM
no one needs DFO
despair 1
15:24
people need to get their shit straight
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Netizenne 14-Aug-22 03:24 PM
https://open.spotify.com/track/04zxGiXcmNQ0m9oDXtwo18?si=ZRaU6GGgT7SNYe8gwrcYXg This song by gorillas has the same back track as a sewerslvt song
15:24
But without the breaks rip
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Deleted User 14-Aug-22 03:24 PM
gorillaz
15:25
my fav band
15:25
...
15:25
when I was 12 yrs old
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Deleted User
when I was 12 yrs old
Netizenne 14-Aug-22 03:25 PM
Lmaooo same
15:26
Ive gone down the music rabbit hole a bit lately and realized I need to find some more accessible music for playing around family lol
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Deleted User 14-Aug-22 03:26 PM
I left a cut cucumber on my desk for 24 hours
15:26
I bet it's toxic now
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Netizenne
Ive gone down the music rabbit hole a bit lately and realized I need to find some more accessible music for playing around family lol
Deleted User 14-Aug-22 03:27 PM
that's one of the reasons not to have a family
👍 1
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Netizenne 14-Aug-22 03:27 PM
familyyyyyyyyyyyyyyyyyy
15:27
but they take care of meeeeee
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Deleted User 14-Aug-22 03:27 PM
emoji_52
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Netizenne
but they take care of meeeeee
Deleted User 14-Aug-22 03:28 PM
21 is the perfect time to change that
15:30
lemons will liberate us folks
15:31
https://www.youtube.com/watch?v=uX35EpKLWu4
Spleen G
Spleen G - Limunska kiselina
15:31
if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap. 🍋
15:31
@Deleted User
15:33
will use citrate as filler now for everything
15:33
it's fucking ridiculous
15:34
Que
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Deleted User
Que
Deleted User 14-Aug-22 03:34 PM
do you even citratize yourself
15:35
Nah scurvy-maxxing (edited)
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Deleted User
Nah scurvy-maxxing (edited)
Deleted User 14-Aug-22 03:37 PM
missing out
15:37
I'm gonna start dosing it constantly
15:39
hmmm
15:39
maybe citrate tablets in shape of lemon
15:40
Effects?
15:40
yeheheheheee
15:40
🍋
15:40
if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap. 🍋
15:46
Limunska kiselina, na usta ide mi slina, ja volim taj spoj, ja sam mašina, ja sam stroj.
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Deleted User 14-Aug-22 04:09 PM
@Yana
16:09
it's ridiculous
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Yana 14-Aug-22 04:11 PM
emoji_25
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Yana
emoji_25
Deleted User 14-Aug-22 04:11 PM
kek
16:11
there must be some errors with that metric
16:11
it's impossible to maintain the ratio they suggest
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Yana 14-Aug-22 04:12 PM
Going gorilla on the leafy greens is the only way without supplements
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Yana
Going gorilla on the leafy greens is the only way without supplements
Deleted User 14-Aug-22 04:13 PM
I see no point
16:13
people eat vegan food, lift weights and have the same bone density
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Netizenne 14-Aug-22 04:13 PM
https://www.reddit.com/r/Nootropics/comments/ao89y9/how_alpha_lipoic_acid_treated_my_lowgrade/?utm_source=share&utm_medium=ios_app&utm_name=iossmf
r/Nootropics - How Alpha Lipoic Acid treated my low-grade depression
10 votes and 10 comments so far on Reddit
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Deleted User 14-Aug-22 04:15 PM
@Yana my bones are good I repeatedly put them to various tests
16:15
average phosphorus intake is 2g, often more
16:15
average calcium intake 600 mg
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Yana 14-Aug-22 04:18 PM
What are some good bone tests
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Yana
What are some good bone tests
Deleted User 14-Aug-22 04:21 PM
falling off a bike
16:22
hitting shit
16:22
skateboarding
16:23
eventually you get a free x ray
16:23
for your feats of bravery
Waow 1
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Deleted User
will use citrate as filler now for everything
Odder_Sea (Glowie) 14-Aug-22 04:25 PM
I bought a lb of citric acid, but have not been able to find it for weeks
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Odder_Sea (Glowie)
I bought a lb of citric acid, but have not been able to find it for weeks
Deleted User 14-Aug-22 04:26 PM
it's cheap as f
16:26
buy another one
16:26
and another one
16:26
and another one
16:26
https://www.youtube.com/watch?v=OFXW3R3Wy-k
RucasLicks
DJ Khaled: Another one (MLG EDIT)
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Deleted User
it's cheap as f
Odder_Sea (Glowie) 14-Aug-22 04:27 PM
I need to buy a bunch of sorghum anywho
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Deleted User 14-Aug-22 04:34 PM
tried 6 mg Agomelatine subL
16:34
stings like a mofo
16:39
not doing this again
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Deleted User 14-Aug-22 05:15 PM
https://www.sciencedirect.com/science/article/abs/pii/S0090429507022534
Citrate Levels in Fresh Tomato Juice: A Possible Dietary Alternativ...
To detect citrate levels in fresh tomato juice, to reveal whether it can be studied for prevention of recurrent hypocitraturic nephrolithiasis.Juices …
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17:16
time to start lycopening the shit out of my diet
“Pete” joined the server. 14-Aug-22 05:36 PM
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Deleted User 14-Aug-22 06:09 PM
Gonna get some lemon juice
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Odder_Sea (Glowie) 14-Aug-22 08:06 PM
Careful, Lycopene is a 5AR inhibitor, can be fatiguing to those with lower levels of DHT I take about 15mg supplemental most days (edited)
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Alyen 14-Aug-22 08:25 PM
https://twitter.com/reuters/status/1233607828239196162?s=21
Author icon
Reuters (@Reuters)
Scientists are experimenting with larva fat to replace butter. They soak insects in water and then mush them with a blender before centrifuges separate a butter-like substance, which the team then uses to bake with https://t.co/dIkTtYWV68
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Deleted User
exercise-induced BDNF gets rid of this chloride accumulation
Netizenne 14-Aug-22 08:32 PM
Do you have any studies on that? Know why that might be? Maybe it’s partly reliant on mechanical filtration the way the lymphatic system is??? Or else is there probably another pathway out there we could theoretically hack?? (edited)
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Netizenne 14-Aug-22 10:48 PM
Does anyone know a good source for pregnenolone nasal sprays?
edy joined the server. 15-Aug-22 12:18 AM
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Odder_Sea (Glowie)
Careful, Lycopene is a 5AR inhibitor, can be fatiguing to those with lower levels of DHT I take about 15mg supplemental most days (edited)
veganpermanently 15-Aug-22 12:41 AM
Nah that's not a prob. Eat your tomato and have it too
00:42
https://youtu.be/SEG92Z_NGJE
JIDVEVO
J.I.D - EdEddnEddy (Official Video)
00:43
@edy welcome to madman's land
ibtisam.midlet pinned a message to this channel. 15-Aug-22 12:44 AM
ibtisam.midlet pinned a message to this channel. 15-Aug-22 12:44 AM
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Netizenne
Do you have any studies on that? Know why that might be? Maybe it’s partly reliant on mechanical filtration the way the lymphatic system is??? Or else is there probably another pathway out there we could theoretically hack?? (edited)
veganpermanently 15-Aug-22 12:45 AM
Nah transporters become regulated. Exercise is mainly an epigenetic intervention. This is why we don't have drugs that mimic exercise fully. It's effects are too complex but also we only have a few thorough screenings for epigenetic effects of small molecules.
ibtisam.midlet pinned a message to this channel. 15-Aug-22 12:50 AM
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ibtisam.midlet 15-Aug-22 01:04 AM
If you want to die read pinned messages 😂
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Netizenne 15-Aug-22 01:16 AM
https://open.spotify.com/album/53TG5hOEgGlaPUaDiRPe00?si=TQ3MKLmeRrWTnzx4y8AdEg
Avarrus
Jääportit · Album · 2006 · 5 songs.
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01:16
Such a good albummmm (edited)
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veganpermanently
https://youtu.be/SEG92Z_NGJE
Potential 15-Aug-22 01:31 AM
Did you see his new single? Also very good.
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Potential
Did you see his new single? Also very good.
Deleted User 15-Aug-22 02:31 AM
surprisingly banger thanks for lmk
02:31
https://www.youtube.com/watch?v=EVlGLtCnN-Y
JIDVEVO
JID - Dance Now (Official Video)
emoji_21 1
02:32
man is evolving
02:33
master of rhythm, holder of meaning, wielder of style
TheUnranked joined the server. 15-Aug-22 04:35 AM
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veganpermanently
https://youtu.be/SEG92Z_NGJE
komodo dragon 15-Aug-22 05:24 AM
I'm excited for his new album
05:24
Was bumping DiCaprio 2 like crazy when it came out
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Deleted User
surprisingly banger thanks for lmk
Potential 15-Aug-22 05:45 AM
Yep, he is indeed evolving One of the goats in the future probably.
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Potential
Yep, he is indeed evolving One of the goats in the future probably.
komodo dragon 15-Aug-22 06:03 AM
Really
06:04
JID is very talented but I don't think I can out him up there yet until he proves that with a project
06:05
Artists like Baby Keem is probably one of the next best/big artists (edited)
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Netizenne
Does anyone know a good source for pregnenolone nasal sprays?
ibtisam.midlet 15-Aug-22 06:27 AM
Major ven here don't have it
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Deleted User 15-Aug-22 07:32 AM
https://www.reddit.com/r/gvane/comments/wp14bn/how_do_heroic_doses_feel_to_you_what_is_the_state/
r/gvane - How do heroic doses feel to you? What is the state you en...
0 votes and 0 comments so far on Reddit
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Yana 15-Aug-22 07:39 AM
Took 7g shrooms once and basically felt sober
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Yana
Took 7g shrooms once and basically felt sober
Deleted User 15-Aug-22 07:40 AM
bunk mushrooms? Cubes?
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Yana 15-Aug-22 07:40 AM
🧊 s
07:40
A friend and I took the same stuff before and it was good
07:40
Same batch
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Deleted User 15-Aug-22 07:40 AM
hmm
07:40
r u on ssris
07:40
or alike
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Yana 15-Aug-22 07:40 AM
No
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MEE6 BOT 15-Aug-22 07:40 AM
GG @Yana, you just advanced to level 4!
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Yana 15-Aug-22 07:40 AM
THC gives me more visuals than the few times I took shrooms
07:40
LSD is another story
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Deleted User 15-Aug-22 07:41 AM
THC does produce visuals for me
07:41
mushrooms produce visuals as well but they're nothing compared to the whole experience I described in the article
07:42
I have met a few people like u
07:42
with variable response to the same mushrooms
07:42
I find it peculiar
07:43
even DMT some people are immune at times
07:43
I haven't a clue why this is
07:44
maybe there's an endogenous antagonist of 5ht2a
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Yana 15-Aug-22 07:45 AM
Low 5ht2a-mglur2 heteromerization?
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Yana
Low 5ht2a-mglur2 heteromerization?
Deleted User 15-Aug-22 07:46 AM
the irregular pattern of this phenomenon would suggest otherwise
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Yana 15-Aug-22 07:47 AM
I mean I wasn't "sober" that one time but it was just like the mind was too clean
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Deleted User 15-Aug-22 07:47 AM
it appears more likely there's a protein or even a small molecule that prevents the effect of 5ht2a activation on mGlur2 (edited)
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Deleted User 15-Aug-22 09:06 AM
https://www.youtube.com/watch?v=Ga92yvgarT8
FOMH
SHDOW - Spirit.
09:06
we're all gonna make it bruhs
09:06
decided I'll go persuade my doctor to prescribe me cetirizine tomorrow @ibtisam.midlet wish luck
emoji_37 1
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ibtisam.midlet 15-Aug-22 09:07 AM
Overdose! Overdose!
09:07
Never OTC did not work for me with it (edited)
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ibtisam.midlet
Never OTC did not work for me with it (edited)
Deleted User 15-Aug-22 09:09 AM
high dose nettle extract did make me regrow my hair in 2015 but it also produced gynecomastia and fluid discharge in the right boob
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ibtisam.midlet 15-Aug-22 09:11 AM
Yeah possibility is these things is considerable but if you found something's works then its easy to mitigate the side effect in way or other
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ibtisam.midlet
Yeah possibility is these things is considerable but if you found something's works then its easy to mitigate the side effect in way or other
Deleted User 15-Aug-22 09:12 AM
yeah I could go have gyno surgery
09:12
but that's too expensive for my cheap booty
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ibtisam.midlet 15-Aug-22 09:12 AM
Nahh not that lol
09:12
there anti gyno meds
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Deleted User 15-Aug-22 09:12 AM
also it produced erectile dysfunction
09:12
tho' reversible
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ibtisam.midlet 15-Aug-22 09:13 AM
How does nettle do it from first
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ibtisam.midlet
How does nettle do it from first
Deleted User 15-Aug-22 09:13 AM
it is likely multimodal
09:13
I have produced my own extract, nothing else worked
09:14
tea, topical, etc. Only my own extract
09:14
oral
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ibtisam.midlet 15-Aug-22 09:14 AM
We have a lot of bisexuals here I would told them to grow boobs emoji_51 emoji_49
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Deleted User 15-Aug-22 09:15 AM
idk about that
09:15
gynecomastia is very unpleasant I would recommend it to nobody
09:15
it itches, reacts to random stuff like foods, temperature change, touch, etc.
09:16
it produces a discharge which would be embarassing for anyone
09:16
but that's just my experience
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ibtisam.midlet
How does nettle do it from first
Deleted User 15-Aug-22 09:17 AM
https://www.ingentaconnect.com/content/ben/ctm/2017/00000003/00000003/art00003 (edited)
09:19
this hair growth effect and the accompanying feminization and erectile dysfunction is likely due to the inhibition of 5 alpha reductase.
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MEE6 BOT 15-Aug-22 09:19 AM
GG @Deleted User, you just advanced to level 14!
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Deleted User 15-Aug-22 09:19 AM
the hair growth is also likely to be promoted by it's antiinflammatory properties.
09:21
it is also an aromatase inhibitor which would make one think it would stop gynecomastia, but the net effect is negative because DHT is a powerful inhibitory factor in the breast tissue and even without estrogen, with enough prolactin and IGF1 the tissue can grow.
09:22
all in all it's a very dirty drug if we're looking at it from this perspective. the negative effects can even be pronounced with topical use.
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ibtisam.midlet 15-Aug-22 09:28 AM
interesting
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MEE6 BOT 15-Aug-22 09:28 AM
GG @ibtisam.midlet, you just advanced to level 13!
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Alyen 15-Aug-22 10:49 AM
brehhhh homie got fucked up
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ibtisam.midlet 15-Aug-22 10:53 AM
What heppen
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ibtisam.midlet
What heppen
Alyen 15-Aug-22 11:12 AM
I was referring to the guy getting gyno and ED from nettle extract
11:12
I did fall off my skateboard recently and my back hurts rn tho :/
❤️ 1
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Alyen
I was referring to the guy getting gyno and ED from nettle extract
veganpermanently 15-Aug-22 11:22 AM
Don't worry I reversed it both
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Alyen 15-Aug-22 11:39 AM
Prove it post ur chest area
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Deleted User 15-Aug-22 01:22 PM
I am becoming Goku
13:22
13:22
13:23
13:23
13:24
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Deleted User 15-Aug-22 01:39 PM
someone help me source galantamine bulk pleaaase
13:39
I need 100 g
13:40
pure powder obviously
13:45
Image attachment
13:45
roflmaooo
13:47
https://pubmed.ncbi.nlm.nih.gov/22746245/
Microdose lithium treatment stabilized cognitive impairment in pati...
A lower incidence of dementia in bipolar patients treated with lithium has been described. This metal inhibits the phosphorylation of glycogen-synthase-kinase 3-α and β, which are related to amyloid precursor protein processing and tau hyperphosphorylation in pathological conditions, respectively. F …
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13:47
300 mcg
13:47
cool
13:51
https://soundcloud.com/subaruusux/pwm-angelic
5ubaruu
pwm angelic
track from Human Divided Vol. 1
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13:51
transcend motherfuckers
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ibtisam.midlet
there anti gyno meds
Potential 15-Aug-22 01:56 PM
Anti-prolactin compounds?
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Potential
Anti-prolactin compounds?
Deleted User 15-Aug-22 01:56 PM
Modafinil fixed it
13:56
also fasting, Rapamycin
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Deleted User
Modafinil fixed it
Potential 15-Aug-22 01:56 PM
Interesting.
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Deleted User 15-Aug-22 01:56 PM
lots of endurance exercise
13:57
AMPK activation
13:57
nook IGF1 mTOR
13:57
activate dopamine receptors
13:57
downregulate 5HT2C
13:57
etc
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Potential
Interesting.
Deleted User 15-Aug-22 01:58 PM
Armoda downregulates prolactin and nightly GH release
13:58
dual action very effective
13:58
I have to use agomelatine to maintain quality of sleep
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13:59
but this helps the gyno even more
13:59
however I wasn't doing this all because of gyno but because of the nootropic effect
13:59
getting rid of the gyno was a nice side 😛
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14:01
@Netizenne I'm making a breakcore mix motherfucker
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Deleted User
Armoda downregulates prolactin and nightly GH release
Potential 15-Aug-22 02:02 PM
https://pubmed.ncbi.nlm.nih.gov/16401653/
Comparison of pramipexole and modafinil on arousal, autonomic, and ...
The noradrenergic locus coeruleus is a major wakefulness-promoting nucleus of the brain, which is also involved in the regulation of autonomic and endocrine functions. The activity of the locus coeruleus is believed to be tonically enhanced by a mesocoerulear dopaminergic pathway arising from the ve …
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Deleted User
@Netizenne I'm making a breakcore mix motherfucker
Potential 15-Aug-22 02:02 PM
Link it when it's done.
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Potential
Link it when it's done.
Deleted User 15-Aug-22 02:03 PM
in a few mo roflmao
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Deleted User
in a few mo roflmao
Potential 15-Aug-22 02:04 PM
Exactly. I will remember.
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Deleted User 15-Aug-22 02:04 PM
I'm cheap I don't wanna buy a turntable so I just wait for my friend to let me play at his house 😛 (edited)
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Deleted User
I'm cheap I don't wanna buy a turntable so I just wait for my friend to let me play at his house 😛 (edited)
Potential 15-Aug-22 02:04 PM
Maybe try it first at your friend's house.
14:05
Or borrow it for an undefined amount of time if he's not using it. (edited)
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Deleted User 15-Aug-22 02:05 PM
turntable is the last on my list lel
14:05
nah he's using it
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14:05
that's why I must wait
14:06
already played a few times
14:06
it's fun as hell
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Potential 15-Aug-22 02:06 PM
Playing at a party as a DJ is on my bucket list. (edited)
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Deleted User 15-Aug-22 02:07 PM
it's so cool
14:07
when you see drugged out people drooling over the speakers
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Deleted User
when you see drugged out people drooling over the speakers
Potential 15-Aug-22 02:07 PM
Utopia.
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Potential
Utopia.
Deleted User 15-Aug-22 02:08 PM
and you're all clear headed nooted up ready to strike the mofo who breaks the equipment emoji_50
14:09
then you shut off bass and echo and reverb over only the high
14:09
motherfuckers transcend
14:09
sadly they don't remember it day after
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Deleted User
Armoda downregulates prolactin and nightly GH release
Yana 15-Aug-22 02:11 PM
Oh dayum are there actual differences like this between moda and armoda beyond half life or is that just what you were taking
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Yana
Oh dayum are there actual differences like this between moda and armoda beyond half life or is that just what you were taking
Deleted User 15-Aug-22 02:11 PM
armoda is the active part of modafinil
14:11
I'm not sure esmoda does anything worthwhile
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Yana 15-Aug-22 02:11 PM
So is S-moda no?
14:12
I thought S-moda is just modafinl with like 6 hour half life. But no clinical efficacy or something
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Deleted User 15-Aug-22 02:33 PM
@komodo dragon I forgot to tell you I don't hate all peptides. I love dipeptides. They're all orally active, never heard of antibodies to them, they are usually very stable compounds, they're easy and cheap to produce.
14:35
they can also be grafted to various small molecules to yield extra activities, reduce sides, improve potency, pharmacokinetics, etc.
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Deleted User
@komodo dragon I forgot to tell you I don't hate all peptides. I love dipeptides. They're all orally active, never heard of antibodies to them, they are usually very stable compounds, they're easy and cheap to produce.
komodo dragon 15-Aug-22 02:36 PM
not all peptides are created equal
14:36
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komodo dragon
not all peptides are created equal
Deleted User 15-Aug-22 02:36 PM
indeed, but the rule of thumb goes, the bigger the worse
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Deleted User
@Netizenne I'm making a breakcore mix motherfucker
Netizenne 15-Aug-22 02:38 PM
Waow
14:38
I wish you good luck, break core soothes the soul!!!!!!!!!!!
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Deleted User 15-Aug-22 02:38 PM
@Netizenne u got me hooked
14:39
riding with breakcore is unlike anything else
14:39
I have not even taken armoda with it yet (edited)
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Yana 15-Aug-22 02:42 PM
https://www.youtube.com/watch?v=sRUmHHWrDxM https://www.youtube.com/watch?v=100g5RBV18c
ソルス
wtchx - break! the beginning of the end
Sewerslvt
Sewerslvt - Blooming Iridescent Flower
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Deleted User
@Netizenne u got me hooked
Netizenne 15-Aug-22 02:43 PM
I got into breakcore by listening to sewerslvt in 2020 cause the people I hung out with in vr played it a lot
14:43
https://m.youtube.com/watch?v=sHwqp0hTiAU (edited)
theuppermostinlife
Sewerslvt - Selected Works (2017-2021)
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Netizenne
https://m.youtube.com/watch?v=sHwqp0hTiAU (edited)
Netizenne 15-Aug-22 02:44 PM
This is a really nice playlist
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Deleted User
and you're all clear headed nooted up ready to strike the mofo who breaks the equipment emoji_50
Potential 15-Aug-22 02:45 PM
Lol something along those lines.
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Deleted User 15-Aug-22 02:47 PM
u know what really fascinates me
14:48
the fact that serotonin metabolism is dependent on dopamine metabolism
14:48
it is so so perfect
14:48
God is great
14:50
we need to find ways to make DBH go brr
14:50
cuz once we do we will improve our circadian rhythms immeasurably with no detriment
14:51
it will reduce oxidative load immensely as well
14:51
increase brain plasticity
14:51
etc.
14:52
just time selective overexpression of a single enzyme
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Deleted User 15-Aug-22 03:03 PM
https://www.reddit.com/r/Nootropics/comments/woh2s2/good_mood_increases_creativity_and_a_bad_mood/
r/Nootropics - Good mood Increases Creativity, and a Bad mood Ampli...
68 votes and 15 comments so far on Reddit
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Netizenne 15-Aug-22 03:59 PM
https://pubmed.ncbi.nlm.nih.gov/12650926 Sphingosine 1 phosphate is a sphingomyelinase inhibitor / FIASMA (edited)
Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks a...
Sphingosine-1-phosphate (Sph-1-P) regulates critical cellular functions including cell proliferation, differentiation, angiogenesis, and cell survival. However, its mechanisms of action are incompletely understood. Here, we show a novel biological effect of Sph-1-P: inhibition of acidic sphingomyeli …
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komodo dragon 15-Aug-22 10:33 PM
@veganpermanently @Deleted User @Potential pray for haiti is such a good album man
The Duke of Wellington joined the server. 15-Aug-22 10:58 PM
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The Duke of Wellington
Joined the server.
Deleted User 15-Aug-22 11:02 PM
Sticker
23:02
the adder is getting fatter
23:04
The Olmec tribes created images of a toad god of rebirth, eating its own skin. It is reborn by consuming itself, caught in a cycle of death and rebirth, like people, and like the natural world itself. @Netizenne 😮
23:07
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Deleted User 15-Aug-22 11:29 PM
https://www.youtube.com/watch?v=1nLnR8yK_BA
FrenchMontanaVEVO
French Montana - Mopstick (Official Music Video) ft. Kodak Black
23:29
@komodo dragon I haven't a clue why but lately I started to like the music of these two sleezebags
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komodo dragon 15-Aug-22 11:32 PM
Lmfao
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Deleted User 15-Aug-22 11:33 PM
Image attachment
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komodo dragon 15-Aug-22 11:33 PM
Kodak isn't that bad
23:33
French Montana though
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Deleted User 15-Aug-22 11:33 PM
him sleezing all over the beat
23:33
I like it
23:33
is it gay
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komodo dragon 15-Aug-22 11:33 PM
No
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komodo dragon
French Montana though
Deleted User 15-Aug-22 11:34 PM
umma change yuh mind
23:34
https://www.youtube.com/watch?v=RaVewRMHX6o
SkillibengVEVO
Skillibeng - Whap Whap (Official Video) ft. Fivio Foreign, French M...
23:34
@komodo dragon check his delivery here
23:34
so fucking hype
23:35
riding 60 flat on my bike listening to it
23:37
tbh
23:37
not much else
23:37
roflmao
23:40
https://www.youtube.com/watch?v=SO3-speGvdc
BustaRhymesVEVO
Busta Rhymes, M.O.P. - Czar (Official Video)
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23:41
Busta tho
23:41
lights the network every single time
23:42
https://www.youtube.com/watch?v=Yl_-3oSlWaU
BustaRhymesVEVO
Busta Rhymes - Look Over Your Shoulder (Lyric Video) ft. Kendrick L...
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Deleted User
@komodo dragon check his delivery here
komodo dragon 15-Aug-22 11:44 PM
I like repping my fellow Moroccans but I'm not really a fan of his music
23:44
Fivio Foreign is great though
23:44
Don't have an idea about french rap
23:47
Listen to westside Gunn pray for Paris album though
23:47
That & pray for Haiti is what I've been listening a lot to lately
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Deleted User 16-Aug-22 03:17 AM
what strains
03:17
anything else?
03:18
good luck
03:18
outdoors?
03:18
it's a bit late for that
03:18
I'm an agriculturalist btw
03:19
I can help u if u have questions
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Deleted User 16-Aug-22 03:27 AM
@ibtisam.midlet I just realized cetirizine is one-time-prescription in my country (edited)
03:28
fuck that
03:29
I need a new doc
03:29
someone I can call and say hey man gimme this gimme that
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MEE6 BOT 16-Aug-22 03:29 AM
GG @abcd, you just advanced to level 1!
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Deleted User 16-Aug-22 03:29 AM
everything is so strict here
03:29
you can't get almost nothing without prescription
03:30
and the one-time-prescriptions are a great nuisance
03:30
Croatia
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Deleted User 16-Aug-22 03:30 AM
they're all digital here you can't cheat it
03:30
unless you hack and that's terrorism
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ibtisam.midlet 16-Aug-22 03:31 AM
Lol I got cit for 100mg/0.5$ unlimited amount
03:31
This fucked up country has some benfits
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ibtisam.midlet
This fucked up country has some benfits
Deleted User 16-Aug-22 03:32 AM
they usually do
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ibtisam.midlet
Lol I got cit for 100mg/0.5$ unlimited amount
Deleted User 16-Aug-22 03:32 AM
do you know if there's systemic absorption with topical
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Deleted User
do you know if there's systemic absorption with topical
ibtisam.midlet 16-Aug-22 03:42 AM
There is no study made for this subject
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ibtisam.midlet
There is no study made for this subject
Deleted User 16-Aug-22 03:44 AM
urine HPLC would be enough to prove this
03:45
why
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Deleted User 16-Aug-22 03:47 AM
IMO it would produce an inoptimal state
03:48
no it would be like Buspirone
03:48
it would feel good yes
03:48
but it would decrease cognition and analytical thought, increase risk of dementia
03:49
it would create a passive coping state
03:49
we went over this a few days ago
03:49
it's a very dumb way to stop depression
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MEE6 BOT 16-Aug-22 03:49 AM
GG @Deleted User, you just advanced to level 15!
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Deleted User 16-Aug-22 03:50 AM
🤦‍♂️
03:51
anyways if I could I would knock out post synaptic 5HT1A
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Deleted User 16-Aug-22 03:51 AM
because it generates a warrior-like mindset
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MEE6 BOT 16-Aug-22 03:52 AM
GG @abcd, you just advanced to level 2!
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Deleted User 16-Aug-22 03:52 AM
depends
03:52
if you wanna be a pussy yes
03:52
😂
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Netizenne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ Two ways of dealing with your problems: Active coping (problem solving) Passive coping (problem ignoring/accepting) Both are stress responses
Deleted User 16-Aug-22 03:53 AM
@abcd
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Deleted User 16-Aug-22 03:54 AM
I prefer to improve my life before I improve my mind
03:55
for that I need low 5HT1A
03:55
and high 5HT2A
03:55
they form heteromers so you can't have both
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Deleted User 16-Aug-22 03:55 AM
I like to call it sincere escapism
03:56
make effort to make your life self sustainable
03:57
freedom from other people decreases stress levels globally
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Deleted User 16-Aug-22 03:57 AM
no it's not
03:57
it never is
03:57
it's a spectrum
03:58
but ultimately there is always someone you need for something
03:58
you grow you food?
03:58
your produce your own energy?
03:58
your own medicine?
03:58
drugs?
03:59
you can spend 5 yrs alone without yearning for social connection?
03:59
you can spend 5 yrs celibate without relapsing masturbating?
03:59
etc.
03:59
so many levels of freedom in life
03:59
at the end of it all
03:59
you live in a country
03:59
that country has laws
04:00
which limit your freedom immensely
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Deleted User 16-Aug-22 04:01 AM
I disagree
04:01
this is 5HT1A thinking
04:02
we need to produce solutions, if we don't, everything will crumble
04:02
2nd law of thermodynamics
04:02
whatever doesn't improve worsens
04:03
I would rather stay in this biological form eating delicious food for 10k yrs
04:05
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Deleted User 16-Aug-22 04:06 AM
no that is in the case of reversed monoamine transporters
04:06
this state is anti-immortalist
04:06
creates immense oxidative load
04:06
I work against this state
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Deleted User 16-Aug-22 04:06 AM
no
04:07
you inhibit MAO B in this state and WORSEN the oxidative stress
04:07
https://pubmed.ncbi.nlm.nih.gov/22407500/
The effect of adenosine A(2A) receptor antagonists on hydroxyl radi...
It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that adenosine A(2A) receptor antagonist …
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04:07
Home BLOW YOUR MIND WITH SCIENCE
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Deleted User 16-Aug-22 04:07 AM
autoxidation
04:07
MAO B is endogenous
04:08
why would the body produce a protein that makes damage to the body
04:08
it makes no sense
04:08
MAO B is protective against VMAT2 dysfunction
04:08
you don't have understanding of this sry I'm not here to argue
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Deleted User 16-Aug-22 04:09 AM
study release dynamics
04:10
you will understand that vesicular release is 100% necessary to keep oxidative load restrained
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Deleted User 16-Aug-22 04:10 AM
actually I prefer to call those substances reuptake transporter agonists
04:11
they don't inhibit the transporter, they reverse it
04:11
like cocaine, methylphenidate, amphetamine
04:11
modafinil is a true reuptake inhibitor
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Deleted User 16-Aug-22 04:12 AM
again, your understanding is brief
04:12
you don't have a clue about transporter conformations
04:12
I can teach but you seem stubborn, set in your ways
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MEE6 BOT 16-Aug-22 04:12 AM
GG @abcd, you just advanced to level 3!
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Deleted User 16-Aug-22 04:12 AM
mkay
04:13
so the transporters can have 3 states
04:13
one is uptake, that's normal, it pulls monoamines to the neuron cytosol from the presynaptic cleft and from cytosol to vesicules
04:14
another is inhibition, it's when the transporter does not work anymore
04:14
and the third state is called open-to-out conformation, it's when the transporter leaks contents in the opposite direction of normal
04:15
the third state is what methylphenidate, cocaine and amphetamine produce
04:15
mph and cocaine do not touch VMAT2
04:15
but amphetamine produces open-to-out conformation for VMAT2 too
04:16
this creates a brain state that's independent of cellular energy, it does not matter if mitochondria produce ATP or not, if you eat enough, if you're healthy or sick (edited)
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Deleted User
Croatia
Yana 16-Aug-22 06:08 AM
why not thailand
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Yana 16-Aug-22 06:29 AM
Why are all the other guys' messages deleted tho
06:29
Farewell chlo
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ibtisam.midlet 16-Aug-22 07:01 AM
unusual idea: https://discord.com/channels/1001420842179239936/1001427252543758357/1009098795931418685
chrisO joined the server. 16-Aug-22 12:16 PM
SAGE（２０２２） joined the server. 16-Aug-22 12:18 PM
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Deleted User
you don't have a clue about transporter conformations
Deleted User 16-Aug-22 01:00 PM
So citric acid is based?
emoji_37 1
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ibtisam.midlet 16-Aug-22 01:00 PM
Fuck Thailand ahhh Why you deleted the message 😅
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Deleted User 16-Aug-22 01:00 PM
Dw about it
emoji_49 1
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Alyen 16-Aug-22 01:01 PM
What type of stf
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MEE6 BOT 16-Aug-22 01:01 PM
@Alyen, you just advanced to level 2 respect++
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Alyen 16-Aug-22 01:01 PM
Std
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Deleted User 16-Aug-22 01:01 PM
Cab I get citric acid from lemon juice?
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Alyen 16-Aug-22 01:01 PM
Nooo
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Deleted User
Cab I get citric acid from lemon juice?
ibtisam.midlet 16-Aug-22 01:02 PM
they use it to convert some drugs, so yes
13:02
Addictio cause you to be smart
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Deleted User 16-Aug-22 01:03 PM
Idk how much
13:03
I'll just wing it
13:05
Taking creatine and lemon juice
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Deleted User
Cab I get citric acid from lemon juice?
Odder_Sea (Glowie) 16-Aug-22 03:38 PM
if your mind isn't as sharp, if you feel brain fogged, if you long for an instant glimpse of clarity Here's a lemon. When life gives you lemons you supply your acetyl CoA cycle with the most important nutrients. It makes your mitochondrion go brrr and your brain ready, steady, eager to snap. 🍋
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Deleted User 16-Aug-22 04:48 PM
Lmao
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ibtisam.midlet 16-Aug-22 05:44 PM
For who want to understand plasticity more (AFAIK) https://discord.com/channels/1001420842179239936/1002135152778035220/1008831273927725226
17:45
Plasticity receptors seems to have other functions then this , which I don't know shit about
17:45
Anyone know more feel free to give input
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Deleted User
So citric acid is based?
The Blur 16-Aug-22 06:08 PM
Manufactured citric acid no wtf. Who gave u that idea?
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Deleted User 16-Aug-22 06:38 PM
Resolution thought
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Deleted User
I prefer to improve my life before I improve my mind
Alyen 16-Aug-22 06:42 PM
🥴
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The Blur
Manufactured citric acid no wtf. Who gave u that idea?
Odder_Sea (Glowie) 16-Aug-22 07:22 PM
VP
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Deleted User
Resolution thought
The Blur 16-Aug-22 07:23 PM
?
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Odder_Sea (Glowie)
VP
The Blur 16-Aug-22 07:23 PM
Who is VP
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The Blur
Who is VP
Odder_Sea (Glowie) 16-Aug-22 07:24 PM
@veganpermanently
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The Blur 16-Aug-22 07:24 PM
Oh
19:24
Just to clarify MCA should be avoided. Citric acid derived from food is fine (there is no supplement for this)
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The Blur
?
Deleted User 16-Aug-22 07:25 PM
Neuron spike model of working memory
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The Blur
Just to clarify MCA should be avoided. Citric acid derived from food is fine (there is no supplement for this)
Odder_Sea (Glowie) 16-Aug-22 07:25 PM
What's the rationale for avoiding manufactured citric acid?
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Deleted User 16-Aug-22 07:26 PM
It's not just number of items. It's one item and the resolution that that item is represented at
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Alyen 16-Aug-22 07:26 PM
Yeah what exactly makes mca bad but citric acid ok
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Alyen
Yeah what exactly makes mca bad but citric acid ok
Odder_Sea (Glowie) 16-Aug-22 07:27 PM
Sometimes synthesized versions of molecules have no beneficial, or even paradoxical effects compared to natural source. Astaxanthin is an example of this (edited)
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Deleted User 16-Aug-22 07:27 PM
Like a TV is a device which is 1st order of abstraction. Then the TV is the TV. Then specific details like the show playing, the model, the color. Then hyper specific details like the button placement and the writing. This is how working memory works. It's not just a few items
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Odder_Sea (Glowie)
What's the rationale for avoiding manufactured citric acid?
The Blur 16-Aug-22 07:28 PM
Approximately 99% of the world production of MCA is through microbial processes using toxic black mold Aspergillus niger [1].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097542/
Potential role of the common food additive manufactured citric acid...
Citric acid naturally exists in fruits and vegetables. However, it is not the naturally occurring citric acid, but the manufactured citric acid (MCA) that is used extensively as a food and beverage additive. Approximately 99% of the world’s production ...
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Deleted User 16-Aug-22 07:28 PM
Each level down you have exponentially more things to remember since its higher resolution
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Odder_Sea (Glowie)
Sometimes synthesized versions of molecules have no beneficial, or even paradoxical effects compared to natural source. Astaxanthin is an example of this (edited)
Alyen 16-Aug-22 07:28 PM
I dont think thats the case with citric acid
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Deleted User 16-Aug-22 07:28 PM
High IQ individuals might seem to have low WM sometimes but that's just with one resolution
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The Blur 16-Aug-22 07:28 PM
MCA comes from black mold. It’s too expensive for companies to derive it naturally from food
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Alyen 16-Aug-22 07:29 PM
Lmfaoooo what
19:29
Nigga thinks they are making citric acid out if black mold
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Alyen
Nigga thinks they are making citric acid out if black mold
The Blur 16-Aug-22 07:30 PM
Because that is the case. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097542/
Potential role of the common food additive manufactured citric acid...
Citric acid naturally exists in fruits and vegetables. However, it is not the naturally occurring citric acid, but the manufactured citric acid (MCA) that is used extensively as a food and beverage additive. Approximately 99% of the world’s production ...
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Alyen 16-Aug-22 07:30 PM
Apergillus niger and candida is not black mold
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The Blur 16-Aug-22 07:30 PM
Lmfao
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Alyen 16-Aug-22 07:30 PM
Those are native bacteria in your stomach
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The Blur 16-Aug-22 07:30 PM
This guy doesn’t know that aspergillus niger IS black mold
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Odder_Sea (Glowie) 16-Aug-22 07:34 PM
This is four case reports, and the only postulated mechanism is black mold pathogens, which I assume is able to be purified out. Also, IIRC, Aspergilus Niger isn't the "black mold" that tends to cause severe respiratory/CFS diseases, but it's cousin, aspergailus Fumigatus. I'm sure that aspergilus could cause issues in people who have an allergy, But IIRC it's mostly a threat in its live form, when it tries to colonize the lungs
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Alyen 16-Aug-22 07:39 PM
Yeah im retarded..I got it mixed up with the aspergillus you ferment miso with
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The Blur
This guy doesn’t know that aspergillus niger IS black mold
Odder_Sea (Glowie) 16-Aug-22 07:40 PM
It's one of the big three, but IIRC by far the least toxic, mostly a threat due to infection of airways
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Alyen 16-Aug-22 07:40 PM
Still the theory is what, that toxins are somehow staying in the citric acid?
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Odder_Sea (Glowie) 16-Aug-22 07:41 PM
It's the one that frequently grows on fruits and in onions
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Alyen
Still the theory is what, that toxins are somehow staying in the citric acid?
Odder_Sea (Glowie) 16-Aug-22 07:41 PM
I suspect it is an allergic response from people that are allergic to the mold
19:42
I have CFS from living in a house that wound up being condemned due to Starchybortris contamination, had pneumonia off and on for a year
19:42
So I could possibly be in that camp, but since it's a different strain of fungi, I doubt it
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Odder_Sea (Glowie)
I suspect it is an allergic response from people that are allergic to the mold
Alyen 16-Aug-22 07:44 PM
Isnt that the same thing, you are saying something in the mold is staying in the citric acid even after purification
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Alyen
Isnt that the same thing, you are saying something in the mold is staying in the citric acid even after purification
Odder_Sea (Glowie) 16-Aug-22 07:48 PM
That was my takeaway from reading the article, also the only plausible mechanism I can think of
19:49
But I'm sure you can get as much or more Aspergillis, in whole form, just from eating produce
19:49
Including fresh lemons 🍋
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Alyen 16-Aug-22 07:50 PM
Yeah thats interesting
19:54
Its always worrying when the fact checkers tell you not to worry about something
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Alyen
Yeah im retarded..I got it mixed up with the aspergillus you ferment miso with
blank 16-Aug-22 07:56 PM
🤓
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Alyen 16-Aug-22 07:57 PM
Fuck you blank
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MEE6 BOT 16-Aug-22 07:57 PM
@Alyen, you just advanced to level 3 respect++
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Odder_Sea (Glowie)
It's the one that frequently grows on fruits and in onions
Yana 16-Aug-22 08:23 PM
like in my medjool dates?
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Yana
like in my medjool dates?
Odder_Sea (Glowie) 16-Aug-22 08:44 PM
Indeed
20:45
The dreaded "black pit"
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Yana 16-Aug-22 08:45 PM
EXTERMINATE!!!!
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ibtisam.midlet 16-Aug-22 11:19 PM
Extracting dxm looks weird
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Alyen
Fuck you blank
blank 16-Aug-22 11:26 PM
hi
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Deleted User
So citric acid is based?
veganpermanently 16-Aug-22 11:46 PM
Y
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ibtisam.midlet
Extracting dxm looks weird
veganpermanently 16-Aug-22 11:46 PM
Prutty
emoji_37 1
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Deleted User
Cab I get citric acid from lemon juice?
veganpermanently 16-Aug-22 11:47 PM
I recommend tomatoes but lemon is good as well
emoji_37 1
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The Blur
Approximately 99% of the world production of MCA is through microbial processes using toxic black mold Aspergillus niger [1].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097542/
veganpermanently 16-Aug-22 11:51 PM
It's a pure substance who cares where it comes from roflmao. You won't get mold poisoning with citric acid. However they may be other treaths using high doses. I am investigating
23:52
It is an approved food additive so you can use small doses with no worry
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Yana
like in my medjool dates?
veganpermanently 16-Aug-22 11:55 PM
The faint white coating you can observe on the skin of sweet fruits is a strain of yeast similar to Baker's and Brewer's yeast, S. cerevisiae (edited)
23:56
Harmless 👻
23:58
Every other color on food means it has gone bad potentially deadly. If it's thick white it can still be mold but hasn't sporulated yet. Throw
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Alyen
Its always worrying when the fact checkers tell you not to worry about something
Netizenne 17-Aug-22 12:00 AM
Looool
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Netizenne 17-Aug-22 12:51 AM
http://neuroskeptic.blogspot.com/2011/12/psychedelic-tale-of-two.html I found this really nice article
A Psychedelic Tale of Two Neurotransmitters
An unexpected interaction between neurotransmitter systems may explain psychosis and hallucinations, according to a fascinating new paper . ...
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Netizenne
http://neuroskeptic.blogspot.com/2011/12/psychedelic-tale-of-two.html I found this really nice article
ibtisam.midlet 17-Aug-22 01:34 AM
When an agonist bind to receptor complex its agonist its receptor, but prevent the other receptor from getting agonisted without providing any agonist efficacy in replacement
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veganpermanently
It's a pure substance who cares where it comes from roflmao. You won't get mold poisoning with citric acid. However they may be other treaths using high doses. I am investigating
Odder_Sea (Glowie) 17-Aug-22 01:45 AM
Uncompensated metabolic acidosis?
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veganpermanently
The faint white coating you can observe on the skin of sweet fruits is a strain of yeast similar to Baker's and Brewer's yeast, S. cerevisiae (edited)
Odder_Sea (Glowie) 17-Aug-22 01:50 AM
Aspergillis often grows on the inside of dates, between the fruit and the pit. Nicknamed the black pit, absolutely gross, but I'm sure there's plenty in small amounts on lots of dates, that I don't notice. This is the same kind that grows between the paper/layers of onions. It doesn't produce substantial amounts of aflatoxin, like its cousin aspergillis fumigatus, I don't consider it to be a huge health hazard by any stretch when consumed in tiny quantities in food for most people.
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01:51
I'm earing Muscadine grapes from a friend's orchard right now. I'm sure some of these have aspergilis growing in/on them. (edited)
01:52
I think peanuts often get contaminated with aflatoxin, though, possibly through fumigatus, or another strain
01:56
BTW Muscadine grapes? One of the healthiest things in existence, buddy. Its like the American AMLA berry
emoji_50 1
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Netizenne
http://neuroskeptic.blogspot.com/2011/12/psychedelic-tale-of-two.html I found this really nice article
Netizenne 17-Aug-22 02:10 AM
What is the primary endogenous super agonist I wonder?
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Netizenne
What is the primary endogenous super agonist I wonder?
veganpermanently 17-Aug-22 02:11 AM
Bofutenine
02:11
🐸
02:12
5 Meo as well
02:13
Serotonin itself could probably be psychedelic in specific brain states
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Netizenne 17-Aug-22 02:13 AM
DMT possibly???
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Netizenne
DMT possibly???
veganpermanently 17-Aug-22 02:14 AM
Prolly but it is weaker compared to what I mentioned
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veganpermanently
Serotonin itself could probably be psychedelic in specific brain states
Netizenne 17-Aug-22 02:14 AM
It’s no superagonist tho!
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Netizenne
It’s no superagonist tho!
veganpermanently 17-Aug-22 02:15 AM
The comformation of the heteromer can change
😮 2
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Netizenne 17-Aug-22 02:15 AM
Owhhh so many factors
02:18
What’s are the most common natural situations in which 5HT2a and mGluR2 interact, what is the natural function of their relationship????
02:18
Can only wonder
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veganpermanently
The comformation of the heteromer can change
Netizenne 17-Aug-22 02:25 AM
Altered topography 😵‍💫
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Netizenne
What is the primary endogenous super agonist I wonder?
ibtisam.midlet 17-Aug-22 03:12 AM
DMT but trigger just when you die (edited)
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Netizenne
DMT possibly???
ibtisam.midlet 17-Aug-22 03:12 AM
Yeah
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ibtisam.midlet
DMT but trigger just when you die (edited)
veganpermanently 17-Aug-22 04:34 AM
Nah I'm pretty sure schizoautist spectrum people release it on the daily
😂 2
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ibtisam.midlet 17-Aug-22 04:43 AM
We need someone on benzo here
🤣 2
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blank 17-Aug-22 08:24 AM
@ibtisam.midlet why did you steal Swiss chads PFP this is so confusing
emoji_51 2
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ibtisam.midlet 17-Aug-22 08:40 AM
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veganpermanently 17-Aug-22 08:41 AM
Make her look to the right so we can tell you apart
08:41
Horizontal flip
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veganpermanently
It is an approved food additive so you can use small doses with no worry
The Blur 17-Aug-22 10:43 AM
Lmfao the term approved means nothing
10:43
Keep clinging to your FDA approved nonsense. You will definitely outlive us all
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veganpermanently
It's a pure substance who cares where it comes from roflmao. You won't get mold poisoning with citric acid. However they may be other treaths using high doses. I am investigating
The Blur 17-Aug-22 10:44 AM
Blocked for spreading your false information and endangering people
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MEE6 BOT 17-Aug-22 10:44 AM
@The Blur, you just advanced to level 3 respect++
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ibtisam.midlet 17-Aug-22 01:46 PM
Majority always label minority opinion as pseudoscience
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ibtisam.midlet
Majority always label minority opinion as pseudoscience
veganpermanently 17-Aug-22 02:31 PM
The prob is he tried to substantiate his statement saying citrate is not healthy because it's produced by Aspergillus sp. This is nonsense. Now he's saying I'm endangering ppl saying they can consume something everyone consumes anyways. Obv if u were to capsulate pure citric acid it would cause irritation but dude use common sense and do look it up. It's safe to add to water at least 5 g/L if not more
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ibtisam.midlet 17-Aug-22 02:50 PM
It was just thought
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ibtisam.midlet
Majority always label minority opinion as pseudoscience
Potential 17-Aug-22 02:53 PM
This is true.
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Yana 17-Aug-22 02:58 PM
pretty pictures 😻 https://www.frontiersin.org/articles/10.3389/fpls.2020.00357/full
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Frontiers | Plant Glycosides and Glycosidases: A Treasure-Trove for...
Plants contain numerous glycoconjugates that are metabolized by specific glucosyltransferases and hydrolysed by specific glycosidases, some also catalyzing synthetic transglycosylation reactions. The documented value of plant-derived glycoconjugates to beneficially modulate metabolism is first addressed. Next, focus is given to glycosidases, the...
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SAGE（２０２２） 17-Aug-22 03:17 PM
why does alcohol cure my depression @ibtisam.midlet
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SAGE（２０２２）
why does alcohol cure my depression @ibtisam.midlet
Potential 17-Aug-22 03:24 PM
Alcohol being a weak Gaba A agonist probably helps. 👍
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SAGE（２０２２）
why does alcohol cure my depression @ibtisam.midlet
ibtisam.midlet 17-Aug-22 03:54 PM
Seems Your depression is anxiety based
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ibtisam.midlet
Seems Your depression is anxiety based
SAGE（２０２２） 17-Aug-22 03:54 PM
most likely so id say
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SAGE（２０２２）
most likely so id say
ibtisam.midlet 17-Aug-22 03:56 PM
There alcohol acculvent you might cycle them
15:57
Prazepam( slowest benzo in tolerance)
15:57
Pregabaline (calsium channel antagonist)
15:57
Etifoxin (gaba a-rho agonis)
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ibtisam.midlet
Pregabaline (calsium channel antagonist)
SAGE（２０２２） 17-Aug-22 03:58 PM
pregabaline really messes up with my memory though I tried it makes me rather foggy
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ibtisam.midlet 17-Aug-22 03:59 PM
The only anti anxiety that don't mess with memory (they even increase it) is SNRIs exactly strongest one, venalafaxine
16:00
Did you took any before
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ibtisam.midlet
Did you took any before
SAGE（２０２２） 17-Aug-22 04:03 PM
no, but I took NSI 189 before (for 3-4 months) and I feel my anxiety went up significantly after that, as well as my fear response
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MEE6 BOT 17-Aug-22 04:03 PM
@SAGE（２０２２）, you just advanced to level 1 respect++
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ibtisam.midlet 17-Aug-22 04:05 PM
Mislead, SNRIs us serotonin adrenaline's reuptake inhibitor
16:06
This the exact feeling
16:07
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16:07
Face looking is 100%
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SAGE（２０２２） 17-Aug-22 04:09 PM
?
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ibtisam.midlet 17-Aug-22 04:10 PM
Lool you will stay a boy
16:11
I mean the confident etc
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Potential
Alcohol being a weak Gaba A agonist probably helps. 👍
Netizenne 17-Aug-22 04:54 PM
Time to switch to pregnenolone 👍
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ibtisam.midlet
Click to see attachment 🖼️
Sirsadalot 17-Aug-22 05:57 PM
Give me
emoji_1 1
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ibtisam.midlet
Face looking is 100%
Netizenne 17-Aug-22 10:55 PM
She Korean you figure or what?
✅ 1
22:55
They’re expert biohackers over there lol
✅ 1
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ibtisam.midlet 17-Aug-22 11:12 PM
gigantic boobs between
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veganpermanently 17-Aug-22 11:58 PM
- complains of back pain all the time - have to be stabilized while pounding What is the benefit? 🙀
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ibtisam.midlet 18-Aug-22 02:01 AM
feminine feeling ᴗ
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Deleted User 18-Aug-22 09:14 AM
Beauty
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veganpermanently 18-Aug-22 09:15 AM
Beauty is a side effect of function
09:15
Y'all confused as hell
09:16
Function of boob is breastfeeding. if you don't plan to do that it's a burden and looks ugly
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ibtisam.midlet 18-Aug-22 10:52 AM
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Sirsadalot
Give me
Odder_Sea (Glowie) 18-Aug-22 10:55 AM
No
Ban 1
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ibtisam.midlet 18-Aug-22 11:22 AM
I was think its easy to run server without ban
11:22
but when you start being an admin you will find there a lot of variables you was not know about, define why admins have to ban
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Mabus Tiefsee 18-Aug-22 12:36 PM
discord admins must be ugly perverts who never leave their room, you are not fit for that job!
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veganpermanently
- complains of back pain all the time - have to be stabilized while pounding What is the benefit? 🙀
Mabus Tiefsee 18-Aug-22 12:38 PM
training back muscles would be a good idea - however how to do that without getting a wide back?
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veganpermanently
Function of boob is breastfeeding. if you don't plan to do that it's a burden and looks ugly
Mabus Tiefsee 18-Aug-22 12:40 PM
my personal assumption is that female human breast tissue above an B cub is like a peacock tail. And i want to know what happend in prehistoric times to give such a huge selection preasure for that?
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ibtisam.midlet 18-Aug-22 12:49 PM
Lets someone narcissistic attack you here and I'll get popcorn
12:49
instead of banning him
12:49
I have more tolerance then others
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Mabus Tiefsee 18-Aug-22 12:50 PM
nah narcissm is one of the dark traits i did not get
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ibtisam.midlet 18-Aug-22 12:50 PM
But temp ban mostly will be routine
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Mabus Tiefsee 18-Aug-22 12:51 PM
reminds me, in the quail to limusaurus biohacking server was a guy who "did not believe in dinosaures" because they are to big. We all where sad when he left the seerver. It was fun!
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ibtisam.midlet 18-Aug-22 12:51 PM
Better then you gain alot of friends and you found your self parama banned
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Mabus Tiefsee 18-Aug-22 12:53 PM
nah, friends are just an illusion. That way we don't have to admit to ourself that we use humans just for their benefits, while we help them to gain other benefits as well
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veganpermanently
Function of boob is breastfeeding. if you don't plan to do that it's a burden and looks ugly
Netizenne 18-Aug-22 04:12 PM
Function of boob is mostly fertility signalling tbh
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SAGE（２０２２） 18-Aug-22 04:33 PM
also somewhat cultural
16:33
romans didnt like big boobs because they thought they were comical
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komodo dragon 18-Aug-22 04:46 PM
i LOVE big boobs
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Alyen 18-Aug-22 05:02 PM
Anyone here try j147
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SAGE（２０２２）
romans didnt like big boobs because they thought they were comical
Alyen 18-Aug-22 05:03 PM
Yeah right
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Alyen
Yeah right
SAGE（２０２２） 18-Aug-22 05:11 PM
its true https://sartorialadventure.tumblr.com/post/178668256363/ancient-roman-apodesme-worn-by-both-women-and
Sartorial Adventure
Sartorial Adventure
Ancient Roman apodesme, worn by both women and men, folded from a single piece of fabric. The breast band was a normal, if optional, item in a woman’s underwear. Women in Ancient Rome adopted a form...
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Alyen 18-Aug-22 05:51 PM
Yeah thats fake
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Alyen
Yeah thats fake
SAGE（２０２２） 18-Aug-22 06:26 PM
https://www.quora.com/Its-well-known-that-the-ancient-Greeks-and-Romans-disliked-large-penises-because-they-symbolised-lack-of-sexual-restraint-in-men-What-did-they-think-of-large-breasts-on-women
18:26
cope
18:27
roman sculptures in contrast with other civilizations, depicted ideal female forms with small comparatively small breasts
18:28
rome
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18:28
india arround the same period
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SAGE（２０２２）
romans didnt like big boobs because they thought they were comical
Potential 19-Aug-22 12:39 AM
or big dicks that's why all of their male statues have small penises. Their theory was that the longer the penis the more savage/animalistic the person. A small penis was a sign of an intellectual. emoji_49
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00:39
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Potential
or big dicks that's why all of their male statues have small penises. Their theory was that the longer the penis the more savage/animalistic the person. A small penis was a sign of an intellectual. emoji_49
Odder_Sea (Glowie) 19-Aug-22 12:54 AM
I didn't want to contribute to the stereotype that otters are aggresive, savage predators... but alas.
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ibtisam.midlet 19-Aug-22 02:04 AM
Those don't have emoji_24
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Potential
or big dicks that's why all of their male statues have small penises. Their theory was that the longer the penis the more savage/animalistic the person. A small penis was a sign of an intellectual. emoji_49
Deleted User 19-Aug-22 09:13 AM
Or they actually just had small dicks and they knew that making that excuse would make future historians think that they were just lowballing their cocks
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MEE6 BOT 19-Aug-22 09:13 AM
@Deleted User, you have advanced to lvl 6 respect++ emoji_51
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ibtisam.midlet 19-Aug-22 11:07 AM
What yall think about nardil
11:08
Its maio a/b selective irrivisible inhibitor
11:08
can be ultimate biohacking tool
11:10
Instead of spending few k in increasing aadc activity by providing it co-factor , which will end with major oxidative problems due to increased catabolism (edited)
11:10
You can just inhibit monoamine catabolism
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ibtisam.midlet 19-Aug-22 11:22 AM
from then you will need 90% less bromantan then normal people
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ibtisam.midlet
from then you will need 90% less bromantan then normal people
SAGE（２０２２） 19-Aug-22 11:55 AM
how do I shrink my amygdala
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SAGE（２０２２）
how do I shrink my amygdala
ibtisam.midlet 19-Aug-22 11:56 AM
Nardil inhibit other enzyme that breakdown gaba and in therapy doses
11:56
Making it superior then other for social anxiety
11:57
For maio You have inhibited the primary moa for the body to breakdown
11:57
Due to irrrevisible inhibition The body need 14 days to refill maio stockage, and you need just one nardil attached to the enzme to unactivate it forever
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SAGE（２０２２） 19-Aug-22 11:58 AM
are there any bad side-effects
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ibtisam.midlet 19-Aug-22 12:02 PM
The only thing that made maio inhibitors deprecated is that you can't eat cheese or any high thyramin food with it
12:02
Because thyramin is adrenaline releasing agent
12:02
Cause hypertension crisis
12:05
The effectiveness of maios was not able to make them stay in use, and replaced by lower efficiency less side effect alternative SSRIs
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MEE6 BOT 19-Aug-22 12:05 PM
@ibtisam.midlet, you have advanced to lvl 14 respect++ emoji_51
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ibtisam.midlet 19-Aug-22 12:06 PM
To solve hypertension crisis when your adrenaline baseline is 1 there thershould ~3 if you increased aderanaline more then it, then you get hypertension problems
12:06
The problem that maios increase it 5 times
12:06
What you need to do is antagonisting beta receptors sighlightly returning them to safe rang
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ibtisam.midlet 20-Aug-22 12:57 AM
https://youtu.be/m02z4Q9gz7w
waveya 2011
HyunA(현아) -어때? (How's this?)cover dance WAVEYA 웨이브야
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ibtisam.midlet 20-Aug-22 02:29 AM
our research will lead to increased crime emoji_52
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ibtisam.midlet
our research will lead to increased crime emoji_52
Deleted User 20-Aug-22 12:58 PM
He's playing chess cop's playing checkers
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Mabus Tiefsee
discord admins must be ugly perverts who never leave their room, you are not fit for that job!
ibtisam.midlet 20-Aug-22 08:30 PM
@Sirsadalot hit him
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Mabus Tiefsee
discord admins must be ugly perverts who never leave their room, you are not fit for that job!
Sirsadalot 20-Aug-22 08:35 PM
bruh
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ibtisam.midlet
https://youtu.be/m02z4Q9gz7w
Deleted User 20-Aug-22 10:16 PM
U seem obsessed with skimpy girls bro
22:16
I thought it was a one off but now I'm sus
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Drafter 20-Aug-22 10:21 PM
What's the issue
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Netizenne 20-Aug-22 10:22 PM
Nekosob 1
22:23
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Netizenne
Click to see attachment 🖼️
Deleted User 20-Aug-22 10:25 PM
I could have lived 70 years without seeing this
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Deleted User
I could have lived 70 years without seeing this
Mabus Tiefsee 20-Aug-22 10:58 PM
bold of you tu assume you life that long
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MEE6 BOT 20-Aug-22 10:58 PM
@Mabus Tiefsee, you have advanced to lvl 7 respect++ emoji_51
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Deleted User
I could have lived 70 years without seeing this
Sirsadalot 21-Aug-22 02:08 AM
Same bruh
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Artichemillion 21-Aug-22 02:27 AM
Hey everyone. Soonly I will synthesize research chemical called MPEP (similar to MTEP), that have shown its efficiency in treating addiction in mices. Does anybody interested in this RC despite that fact that no one human have tried this?
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Artichemillion
Hey everyone. Soonly I will synthesize research chemical called MPEP (similar to MTEP), that have shown its efficiency in treating addiction in mices. Does anybody interested in this RC despite that fact that no one human have tried this?
ibtisam.midlet 21-Aug-22 06:59 AM
Did you tested mtep? Lithium can be alternative for all of this if it is a start for you. lithium cause learned hopelessness like mglue5 antagonist which mpep selective on it https://en.wikipedia.org/wiki/Lithium_(medication)
Lithium (medication)
Certain lithium compounds, also known as lithium salts, are used as psychiatric medication, primarily for bipolar disorder and for major depressive disorder. In these disorders, it sometimes reduces the risk of suicide. Lithium is taken orally.Common side effects include increased urination, shakiness of the hands, and increased thirst. Serious ...
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06:59
This basically means that lithium have inhibition on that receptor which means the anti addiction effect of lethium is from there
06:59
reduce drug self-administration regardless of dose https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_5 https://en.wikipedia.org/wiki/3-((2-Methyl-4-thiazolyl)ethynyl)pyridine https://en.wikipedia.org/wiki/Fenobam
Metabotropic glutamate receptor 5
Metabotropic glutamate receptor 5 is an excitatory Gq-coupled G protein-coupled receptor predominantly expressed on the postsynaptic sites of neurons. In humans, it is encoded by the GRM5 gene.
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MTEP
3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5. Identified through structure-activity relationship studies on an older mGluR5 antagonist MPEP, MTEP has subsequently itself acted as a lead compound for ...
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Fenobam
Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain. Subsequently, it was determined that fenobam acts as a potent and selective negative allosteric modulator of the metabotropic glutamate receptor subtype mGluR5, and it ha...
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06:59
https://www.sciencedirect.com/science/article/pii/S2468171720300053
Low-dose lithium impact in an addiction treatment setting
This study is to assess the effectiveness of low-dose lithium Carbonate (150 mg) augmentation or as a substitute for synthetic antidepressants and ant…
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07:00
If modulating a feeling like hope reached its maximal benefits then you need to play with other one. (edited)
07:01
There a possibility that the effect is completely based on dose dependant curve realising the fact what "hope" is and expecting how it could cause anti addiction effect You will need high doses.
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Netizenne
Click to see attachment 🖼️
ibtisam.midlet 21-Aug-22 07:20 AM
that type of aesthetic called hime gyaru emoji_7
07:21
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ibtisam.midlet
that type of aesthetic called hime gyaru emoji_7
Netizenne 21-Aug-22 12:46 PM
I neeeed the hime gyaru haaaaat reiflush3
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ibtisam.midlet 21-Aug-22 11:22 PM
After I learned "I promise" I overused it for few weeks, just because how it sound
23:23
Now I have problem payback my promises emoji_6
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Lux ✨ 22-Aug-22 04:58 AM
LOL
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ibtisam.midlet 22-Aug-22 11:01 AM
The moment where Elon Musk made history :The successful rocket launch appeared :Then landing it to be reused elon: where the shine , this is bad :The rocket came back to work and landed smoothly
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Deleted User 22-Aug-22 04:03 PM
I think house flies are getting bigger
16:03
Like the one I just killed was massive
16:03
Like 3-4x the size of flies I'm used to
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Netizenne 22-Aug-22 06:25 PM
Ya we had a monster flying around here the other day too lol
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ibtisam.midlet
Click to see attachment 🖼️
Mabus Tiefsee 22-Aug-22 11:02 PM
filter ir truly as big eyes?
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Mabus Tiefsee
filter ir truly as big eyes?
ibtisam.midlet 22-Aug-22 11:55 PM
its truly, you want one of it emoji_52 ?
23:56
treat her good!
23:57
between my 2nd account her is @elena.final_fail
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Mabus Tiefsee 22-Aug-22 11:57 PM
Nah, as big eyes are creepy in RL, my cousin and her 3 children got as big ones as well... ....besides eyes don't stay fresh for long outside the socket
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Mabus Tiefsee
Nah, as big eyes are creepy in RL, my cousin and her 3 children got as big ones as well... ....besides eyes don't stay fresh for long outside the socket
ibtisam.midlet 22-Aug-22 11:58 PM
big eyes= aniiiiiiiiiime
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Mabus Tiefsee 22-Aug-22 11:58 PM
works only for asians
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ibtisam.midlet 22-Aug-22 11:58 PM
we need more collagen
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Netizenne
Function of boob is mostly fertility signalling tbh
veganpermanently 23-Aug-22 07:25 AM
Yeah in today's day and age. But it does store a lot of fat which could come in handy in prehistoric times esp during breastfeeding. I think this is the reason why it signals fertility in the first place
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ibtisam.midlet 23-Aug-22 02:59 PM
Pig is credible animal Give him your broken phone, trashbin, bag of expired substances and he will convert them to meat
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ibtisam.midlet 23-Aug-22 03:20 PM
🍻
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ibtisam.midlet 24-Aug-22 01:51 AM
Does anyone know how to treat cognitive fatigue?
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ibtisam.midlet
Does anyone know how to treat cognitive fatigue?
veganpermanently 24-Aug-22 02:07 AM
Rest, VMAT2 upregulation, mitochondrial biogenesis
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veganpermanently
Rest, VMAT2 upregulation, mitochondrial biogenesis
ibtisam.midlet 24-Aug-22 02:09 AM
Its not sleep deprivation mediated but just because programming (edited)
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ibtisam.midlet 24-Aug-22 02:22 AM
rest did not help in this
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ibtisam.midlet
Does anyone know how to treat cognitive fatigue?
Netizenne 24-Aug-22 04:58 AM
Reactive oxygen species build up, pushing mitochondrial limits, repairing damage done by ROS from overexertion? lactate maybe (not too sure what lactate does but I think it has to do with literal physical exertion) Oxidative stress is associated with autism too.
04:58
Idk I am fairly certain I have chronic fatigue of some sort and wish I knew the answer despair
04:58
I’m trying to get more exercise
04:59
Got my bike fixed!!! Been heading out to the woods everyday!!
04:59
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05:00
Found some jumps I can graduate too once I get a bit more confident!!
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MEE6 BOT 24-Aug-22 05:00 AM
@Netizenne, you have advanced to lvl 8 respect++ emoji_51
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veganpermanently 24-Aug-22 05:04 AM
Bruh
05:04
How r ur forests so spacious
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Netizenne
Got my bike fixed!!! Been heading out to the woods everyday!!
veganpermanently 24-Aug-22 05:05 AM
That'll fix the fatigue over time
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Netizenne
Got my bike fixed!!! Been heading out to the woods everyday!!
ibtisam.midlet 24-Aug-22 06:37 AM
Yeah that does help noticeably, but I need more!!!
06:37
Look: It start when I'm stuck in a problem, if I stay stuck for 30min I'll get cognitive fatigue until it solved
06:37
Otherwise in normal task archivment manner , I can work like this for weeks with only naps
06:37
It seems that when I'm on goal directed state, I start love the task archivment euphoria, causing me to ignore anxiety, which cause more task completion...
06:37
Until I found my self in problem like now 🥲
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ibtisam.midlet
Until I found my self in problem like now 🥲
veganpermanently 24-Aug-22 07:47 AM
do u have bromantane or modafinil
07:47
but not the analogs
07:47
only armoda works
07:48
memantine should work but the dose required to do this is cognitively impairing through alpha7 inhibition
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ibtisam.midlet 24-Aug-22 07:59 AM
I have source for creatine rhidiola Metformin What would be the most benefitical, knowing that I will overdose
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veganpermanently
memantine should work but the dose required to do this is cognitively impairing through alpha7 inhibition
ibtisam.midlet 24-Aug-22 08:05 AM
Magnesium pidolate injection works, but I did mistake injecting 12g once, due to pidolate being prodrug for glutamate it was capable to overcome mag nmda channel blockage Other then that I need some learning not just keep increasing globale IQ
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ibtisam.midlet
I have source for creatine rhidiola Metformin What would be the most benefitical, knowing that I will overdose
blank 24-Aug-22 08:06 AM
take creatine at least
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08:06
rhodiola is a gamble if it's going to do anything but it can be nice
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ibtisam.midlet 24-Aug-22 08:17 AM
What the effect of metformin was @machineyadav
08:17
Detailed if you can
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blank 24-Aug-22 08:18 AM
lowers blood sugar and some other things
08:18
it's a diabetic medication not sure why it would do anything for fatigue
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ibtisam.midlet 24-Aug-22 08:18 AM
No psychoactive effect
08:18
By increase insuline sensitivity
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ibtisam.midlet
What the effect of metformin was @machineyadav
machineyadav 24-Aug-22 08:18 AM
AMPK activation benefits: insulin sensitivity, energy, mitochondria, less inflammation (edited)
08:18
Gut benefits
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ibtisam.midlet 24-Aug-22 08:19 AM
How it supposed to activate ampk
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ibtisam.midlet
How it supposed to activate ampk
veganpermanently 24-Aug-22 08:19 AM
by virtue of limiting glucose availability
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ibtisam.midlet
How it supposed to activate ampk
machineyadav 24-Aug-22 08:19 AM
Not sure exact mechanisms
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ibtisam.midlet
Does anyone know how to treat cognitive fatigue?
Odder_Sea (Glowie) 24-Aug-22 10:25 AM
I've read some of this is due to buildup of extrasynaptic Glutamate and ROS? I imagine Creatine would be helpful
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blank
rhodiola is a gamble if it's going to do anything but it can be nice
Odder_Sea (Glowie) 24-Aug-22 10:26 AM
I think It's effects are largely down to your COMT genes and expression status
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blank
take creatine at least
Odder_Sea (Glowie) 24-Aug-22 10:27 AM
@ibtisam.midlet What he said. Creatine is OG for this
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ibtisam.midlet 24-Aug-22 01:38 PM
Lisa in Last blackpink song look like a game character
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ibtisam.midlet 24-Aug-22 01:55 PM
@Netizenne What's your k/r selection theories between
13:57
someone mentioned me about it
13:57
emoji_49
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Netizenne 24-Aug-22 05:05 PM
Oxytocin seems to act as an epigenetic switch for controlling the development of a lot traits
17:07
Without an understanding of r/K selection all the various functions and phenotypes oxytocin controls might seem unrelated or random -but if you view it through the lens of a “Life History theory” framework, then it all makes coherent sense. (edited)
17:09
https://incels.wiki/w/Life_history_theory This is a pretty good article on it (up until the CSR section which a different author writes). (They teach this in bio or ecology 101 at university, life history is a pretty core theory). (edited)
Life history theory
Life history theory is a collection of hypotheses in evolutionary biology that explain why animal species differ in so-called life-history traits. These traits include body size (including size at birth), growth and developmental schedules, the number, size, and sex ratio of offspring, reproductive schedules, sex drive, lifespan, extent of inves...
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17:11
It’s basically an axis, a continuum of correlated traits with a basis in reproductive strategies
17:12
Larger species tend to live longer, reproduce less, be more pro social, be more cognitively adaptive on an individual level, etc. -these are all traits of a K-selected slow life history strategist. (edited)
17:13
r-selected Fast life history strategists on the other hand grow up asap, reproduce asap, and maximize reproducing as much as possible. In highly unpredictable environments full of unavoidable disease and predation -to grow up asap and reproduce as much as possible is the most ideal strategy (as opposed to taking your time to develop and putting lots of parental effort into fewer offspring). (edited)
17:15
r-selection is also more ideal in environments not at carrying (K)capacity, where resources are less limited and the competition for them is more lax. (edited)
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17:17
https://www.sciencedirect.com/science/article/pii/S266649762100062X This study basically pins oxytocin as controlling K selected traits
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Love and longevity: A Social Dependency Hypothesis
Mammals, including humans, are reliant for survival and reproduction on adaptations associated with sociality and physiological investment, which can …
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17:21
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17:21
Oxytocin and activity of the HPA-axis (cortisol/stress system) via ACTH basically have opposing effects on the melanocortin system (a group of 5 receptors and their ligands). The different receptors of the melanocortin system (MCR1-5) control for various parts of r/K selective phenotypes -like linear growth rate, mating effort, aggression, etc (edited)
17:24
ACTH in that other drawing is the same as this one, the melanocortin system is a critical component of the HPA axis
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17:25
… Early childhood stress, adversity, or immune insults -can be interpreted as signals of an unstable environment full of unavoidable disease or predation to the body. Growing up fast as possible and reproducing as much as possible becomes the ideal strategy in such an environment -and decreases in oxytocin for life then act as an epigenetic switch to produce that phenotypic strategy. (edited)
17:27
Anyways this all can be useful for predicting who’d make good responders to Semax since it should mimic some of the effects of oxytocin. Probably benefits people with childhood adversity more. (edited)
17:28
Trauma lowers oxytocin: https://www.sciencedirect.com/science/article/pii/S0272735821000283#tf0005 Childhood adversity and stress is associated with decreases oxytocin and the consequent promotion of a fast life history strategy
Developmental programming of oxytocin through variation in early-li...
Despite evidence supporting a role for oxytocin (OT) in regulating social behavior, surprisingly little is known about how this neuropeptide is calibr…
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17:28
Sorry this is so messy :(
17:28
I haven’t been thinking about it much lately, been kinda drifting away from it
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Netizenne 24-Aug-22 06:19 PM
There’s holes in it I don’t understand tho pain
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ibtisam.midlet 24-Aug-22 08:47 PM
It's good as it is
20:47
Humans seems an adepting specie
20:48
Because in 3rd world county people see reproduction as life project
20:48
Between on 1st world country they interested on more big standards
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machineyadav 25-Aug-22 02:40 AM
Netizenne knows amazing things about oxytocin system emoji_51 emoji_50
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Mabus Tiefsee 25-Aug-22 02:53 AM
around one month ago i regained all my tastebuds. Since yesterday i lost them all again 😭
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Mabus Tiefsee
around one month ago i regained all my tastebuds. Since yesterday i lost them all again 😭
veganpermanently 25-Aug-22 03:03 AM
My fasting mimicking protocol fixes this
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Mabus Tiefsee
around one month ago i regained all my tastebuds. Since yesterday i lost them all again 😭
Drafter 25-Aug-22 03:04 AM
You got covid again?
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veganpermanently
My fasting mimicking protocol fixes this
Mabus Tiefsee 25-Aug-22 04:07 AM
yeah they will come back, they always do after an infection.... i am infected again. Could be the 6 time? And the 4th time i lost my tastebuds.
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Drafter
You got covid again?
Mabus Tiefsee 25-Aug-22 04:08 AM
probably, tests say no - but i am high on vitamins therefore false negatives are likely
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ibtisam.midlet 25-Aug-22 09:41 AM
metformin 0.5g (insuline+) 50%LT Repamycin 0.5mg (mtor-) 50%LT Anafranil 18.75mg (SERT/NET-) 72%LT Modafinil 50mg (DAT~) 50%LT Tianpetine 37.5mg (mu~) 95%LT Idra-21 10mg (AMPA+) 33%LT Phenibut 250mg (cal-) 50%LT Mag pidolate 5g (NMDA-) 95%LT
09:42
What ya think about this stack
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Pax1l 25-Aug-22 09:42 AM
That is far too many drugs
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MEE6 BOT 25-Aug-22 09:42 AM
@Pax1l, you have advanced to lvl 1 respect++ emoji_51
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ibtisam.midlet 25-Aug-22 09:43 AM
That's take over the world secret (edited)
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Pax1l 25-Aug-22 09:45 AM
No thats mixing a large number of experimental drugs with no ideal of how they would interact
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ibtisam.midlet 25-Aug-22 09:46 AM
Its microdosing btw
09:46
I'm specialized in combination
09:46
I'll solve problems easily when happen
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Drafter 25-Aug-22 09:47 AM
@Pax1l what do you think about people getting covid repeatedly 3 4 6+ times
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Pax1l 25-Aug-22 09:47 AM
Everyone says theyre an expert in combining drugs but what is your record of accomplishment
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Drafter
@Pax1l what do you think about people getting covid repeatedly 3 4 6+ times
Pax1l 25-Aug-22 09:47 AM
Its sad
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Drafter 25-Aug-22 09:48 AM
I wonder what will be the result of it years down the line if they keep getting reinfected
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Drafter
I wonder what will be the result of it years down the line if they keep getting reinfected
Pax1l 25-Aug-22 09:49 AM
Its never good
09:51
Ive heard from so many people in the noot community that believe they have an idea how to mix noots but from my experience interacting with so many people is that these drugs should not be mixed in such large quantities and using tianeptine which is a tricyclic antidepressant with other drugs is really dangerous
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ibtisam.midlet 25-Aug-22 09:51 AM
My record validity is something will define my safety not yours, so its not something I have to establish
09:52
do those stuff to gain exp, it will help you next
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Drafter 25-Aug-22 09:52 AM
I do a lot of supplements but it's mostly natural stuf, like zinkc magnesium, glycine, betaine
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Pax1l 25-Aug-22 09:53 AM
Whatever you define as safe is not goal oriented towards promoting better cognition
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Drafter 25-Aug-22 09:53 AM
I try to only do things that will help my body do what it wants to do (edited)
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ibtisam.midlet 25-Aug-22 09:53 AM
and take D3- anti impulsivity , when you mix maois with triple releasers (edited)
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Pax1l 25-Aug-22 09:53 AM
This server is called bio-tolerance
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ibtisam.midlet 25-Aug-22 09:53 AM
that's my advice
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ibtisam.midlet
and take D3- anti impulsivity , when you mix maois with triple releasers (edited)
Pax1l 25-Aug-22 09:54 AM
No
09:55
If you are intently focused on just targeting multiple pathways with little focus on their interactions youre not going to reach the highest understanding of biochemistry
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MEE6 BOT 25-Aug-22 09:55 AM
@Pax1l, you have advanced to lvl 2 respect++ emoji_51
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ibtisam.midlet 25-Aug-22 10:12 AM
If you are intently focused on understanding multiple pathways interactions with little focus on the time you waste not experimenting them, you are not going to take over the world
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Pax1l 25-Aug-22 10:13 AM
I do not care what you think
10:14
Ive pioneered the use of more drugs than any single person in the nootropics community and honestly all of you are perpetually stuck in this 2015 mindset
10:15
People have done what they can to try to kill me and i dont think you have what it takes to go through half of it
10:20
What drugs have you synthed
10:24
Is it zero
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ibtisam.midlet 25-Aug-22 10:25 AM
the daily life of research chemicals gambler
10:25
I'm drug user
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Pax1l 25-Aug-22 10:26 AM
So youre a polydrug addict?
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ibtisam.midlet 25-Aug-22 10:27 AM
yeah
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Pax1l 25-Aug-22 10:29 AM
I will find your insecurities and I will use them against you
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ibtisam.midlet 25-Aug-22 10:32 AM
I'm feeling bothered by agreements, so i'll payback -typos
10:38
++ you have unlimited insecurities
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Pax1l 25-Aug-22 10:54 AM
Today im going to snort 200iu of insulin, 500mg dfo, inject 100mcg cb3 and thats my stqck for the day
💟 2
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sono 25-Aug-22 11:26 AM
I saw a vid on youtube talking about a vit D study, and markers for aging, the vit D group had reverse aged about 2 yrs in one test? something like that
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sono
I saw a vid on youtube talking about a vit D study, and markers for aging, the vit D group had reverse aged about 2 yrs in one test? something like that
Pax1l 25-Aug-22 11:28 AM
Id look into getting a liquid vitamin D supplement and using that intranasally
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sono 25-Aug-22 11:29 AM
why would you recommend that?
11:29
i tried liquid vit c.
11:30
liposomoal 2000mg (edited)
11:30
Took 2000iu vit D3 throughout the autumn and winter... But stopped for the summer.
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Pax1l 25-Aug-22 11:31 AM
https://www.jacionline.org/article/S0091-6749(13)02396-8/fulltext#:~:text=Intranasal%20vitamin%20D%20administration%20reduced,systemic%20cytokine%20production%20by%20splenocytes.
11:31
https://pubmed.ncbi.nlm.nih.gov/27671249/
Intranasal administration of vitamin D attenuates blood-brain barri...
In this study, we investigated the role of vitamin D3 (VitD3) on endogenous osteopontin (OPN), a neuroprotective glycoprotein, after subarachnoid hemorrhage (SAH). The endovascular perforation SAH model in Sprague-Dawley rats was used to study the effect of intranasal VitD3 (30 ng/kg) before (Pre-SA …
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sono 25-Aug-22 11:33 AM
in plain english whats the deal with the blood brain barrier thing in that article?
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MEE6 BOT 25-Aug-22 11:33 AM
@sono, you have advanced to lvl 1 respect++ emoji_51
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Pax1l 25-Aug-22 11:35 AM
Intranasal use of vitamin d better targets the brain and improves the function of microglial cells to promote phageocytosis to recycle damaged brain tissue
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sono 25-Aug-22 11:36 AM
Thanks.
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Pax1l 25-Aug-22 11:40 AM
Microglial cells are in essence the immune cells of our brain and in disorders such as stroke or alzheimers the function of microglial cells to break down inflammation deteriorates and even worse feeds forward in the promotion of inflammation through the induction of tnf-a and il-6 release to activate astrocytes which release hepcidin to promote the accumulation of iron within brain cells including microglial cells. This promotes cellular senescence through promoting oxidative stress and breakdown in mitochondrial function
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MEE6 BOT 25-Aug-22 11:40 AM
@Pax1l, you have advanced to lvl 3 respect++ emoji_51
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sono 25-Aug-22 11:42 AM
Should a healthy person be doing intranasal vitD?
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ibtisam.midlet
metformin 0.5g (insuline+) 50%LT Repamycin 0.5mg (mtor-) 50%LT Anafranil 18.75mg (SERT/NET-) 72%LT Modafinil 50mg (DAT~) 50%LT Tianpetine 37.5mg (mu~) 95%LT Idra-21 10mg (AMPA+) 33%LT Phenibut 250mg (cal-) 50%LT Mag pidolate 5g (NMDA-) 95%LT
veganpermanently 25-Aug-22 11:42 AM
reductionistic IMO. clomipramine is a pharmacological clusterfuck. Modafinil does almost nothing to DAT, it's effects are through alpha1 activation and epigenetic effects which will synergize with Tianeptine, may even lead to SS. They may also have additive hepatotoxic effects. I'd just ditch the phenibut and replace the Mg pidolate with other sources of Mg, threonate, malate, aspartate, orotate, chloride
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sono 25-Aug-22 11:46 AM
What's your thinking on this supplement I tried, it seems to do nothing, is it bullshit or real or the wrong type of lithium?
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sono
Should a healthy person be doing intranasal vitD?
Pax1l 25-Aug-22 11:46 AM
Yes vitamin D has not been found to produce harmful effects upto 120k iu per day injected
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Pax1l
Yes vitamin D has not been found to produce harmful effects upto 120k iu per day injected
sono 25-Aug-22 11:47 AM
i once was taking like 15000 iu a day caps and it gave me bad insomnia...
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sono
What's your thinking on this supplement I tried, it seems to do nothing, is it bullshit or real or the wrong type of lithium?
Pax1l 25-Aug-22 11:47 AM
Thats possibly a good choice to have on hand but at such a low dosage it only modulates gsk3b and i have little idea to what degree
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sono 25-Aug-22 11:48 AM
would you recommend lithium as a nootropic?
11:49
i heard theres orotate and lots of other forms.
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sono
i once was taking like 15000 iu a day caps and it gave me bad insomnia...
Pax1l 25-Aug-22 11:49 AM
Vitamin D is a neurosteroid which greatly supports energy and cognitive functions. Its been determined that 120k iu injections of vitamin D in the elderly greatly promoted activity and well being
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sono
would you recommend lithium as a nootropic?
Pax1l 25-Aug-22 11:50 AM
Lithium is fairly underwhelming in comparison to intranasal insulin, intranasal deferoxamine and intranasal Rapamycin
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Pax1l
Yes vitamin D has not been found to produce harmful effects upto 120k iu per day injected
veganpermanently 25-Aug-22 11:51 AM
in b4 amyloid overload
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veganpermanently
in b4 amyloid overload
Pax1l 25-Aug-22 11:53 AM
Where do you have evidence to substantiate that claim. https://pubmed.ncbi.nlm.nih.gov/29257109/
Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and I...
Alzheimer's disease (AD) is characterized by extracellular plaques in the brain, mainly consisting of amyloid-β (Aβ), as derived from sequential cleavage of the amyloid precursor protein. Epidemiological studies suggest a tight link between hypovitaminosis of the secosteroid vitamin D and AD. Beside …
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veganpermanently 25-Aug-22 11:53 AM
it wasn't a claim
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sono 25-Aug-22 11:54 AM
anyone found a cure for grey hair yet>
11:55
im getting some annoying greys, im 40
11:56
i heard chaga mushrooms because of its melanin content...
11:56
but i guess its probably way more complicated than that
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Pax1l 25-Aug-22 11:56 AM
D-pdmp may be a good option https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065400/ (edited)
Inhibition of glycosphingolipid synthesis reverses skin inflammatio...
Sphingolipids have been accorded numerous biological functions however, the effects of feeding a western diet (diet rich in cholesterol and fat) on skin phenotypes, and color is not known. Here, we observed that chronic high-fat and high-cholesterol diet ...
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12:02
We would need a custom synth but this is high on my priority list. I am willing to accept funding towards such a project
12:05
We can also synthesize glutathione capped gold nanoparticles to promote accumulation of gsh in hair follicles
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sono 25-Aug-22 12:07 PM
All way beyond my understanding.
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Pax1l 25-Aug-22 12:10 PM
Its worth exploring d-pdmp to reverse cellular abnormalities in all cell lines
12:12
It should be a simple synth
12:15
Topical deferoxamine may mitigate skin aging and ameliorate hair loss and greying
👍 2
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veganpermanently
reductionistic IMO. clomipramine is a pharmacological clusterfuck. Modafinil does almost nothing to DAT, it's effects are through alpha1 activation and epigenetic effects which will synergize with Tianeptine, may even lead to SS. They may also have additive hepatotoxic effects. I'd just ditch the phenibut and replace the Mg pidolate with other sources of Mg, threonate, malate, aspartate, orotate, chloride
ibtisam.midlet 25-Aug-22 12:40 PM
what you think about oxidase salt
12:41
i can get 200g pidolate acculevent by 0.25$ from it
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Pax1l 25-Aug-22 12:42 PM
Modafinil really isnt that great from what i heard and its controlled in the us
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ibtisam.midlet 25-Aug-22 12:43 PM
does moda decrease time needed to complete a task
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ibtisam.midlet 25-Aug-22 12:53 PM
@Pax1l @Pax1l
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veganpermanently
reductionistic IMO. clomipramine is a pharmacological clusterfuck. Modafinil does almost nothing to DAT, it's effects are through alpha1 activation and epigenetic effects which will synergize with Tianeptine, may even lead to SS. They may also have additive hepatotoxic effects. I'd just ditch the phenibut and replace the Mg pidolate with other sources of Mg, threonate, malate, aspartate, orotate, chloride
Yana 25-Aug-22 01:49 PM
Then why did modafinil lack wakefgulness-promotion in DAT-KO mice? Or are your saying that effect isn't significant
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veganpermanently 25-Aug-22 01:49 PM
Moda is the best productivity drug I've ever tried. Also the best antidepressant
💯 3
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Yana
Then why did modafinil lack wakefgulness-promotion in DAT-KO mice? Or are your saying that effect isn't significant
veganpermanently 25-Aug-22 01:50 PM
kek DAT KO mice are fukd
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Yana 25-Aug-22 01:50 PM
True
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veganpermanently 25-Aug-22 01:51 PM
don't get me wrong, Moda is clearly dopaminergic, but it is a very weak DAT inhibitor. It is a vesicular release agent
13:52
the DAT inhibition is only notable in relation to it's antiaddictive properties against DAT agonists like cocaine, amph and methylphenidate
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ibtisam.midlet 25-Aug-22 01:52 PM
it is established as DAT functional inhibitor see lasts news guys
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ibtisam.midlet
it is established as DAT functional inhibitor see lasts news guys
veganpermanently 25-Aug-22 01:53 PM
pls ref this
13:53
I'm curious
13:53
have not found a definitive study on this
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Yana 25-Aug-22 01:55 PM
https://jpet.aspetjournals.org/content/319/2/561
Modafinil Occupies Dopamine and Norepinephrine Transporters in Vivo...
2-[(Diphenylmethyl) sulfinyl]acetamide (modafinil), prescribed principally to treat narcolepsy, is undergoing assessment for other neuropsychiatric disorders and medical conditions. The neurochemical substrates of modafinil are unresolved. We postulated that modafinil enhances wakefulness by modulating dopamine (DAT), norepinephrine (NET), or se...
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13:55
1115mg HED = 35 +- 12% DAT occupancy in monke (edited)
13:56
Wonder what the number for phenidates/amphetamines are
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MEE6 BOT 25-Aug-22 01:56 PM
@Yana, you have advanced to lvl 5 respect++ emoji_51
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Yana
Wonder what the number for phenidates/amphetamines are
veganpermanently 25-Aug-22 02:00 PM
it's not very relevant because the phenidates and amphs are DAT agonists not inhibitors
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ibtisam.midlet 25-Aug-22 02:10 PM
there multiple things you need to know there something called functional selectivity, when a ligend bind to a protien there multiple pathways he can trigger, some ligends act as agonist on some antagonist in other https://en.wikipedia.org/wiki/Functional_selectivity one of this pathways is beta-arrestine which are implicated on both effect of dopmaine and tolerance ----------- GRK5 and the closely related GRK6 phosphorylate receptors at sites that encourage arrestin-mediated signaling rather than arrestin-mediated receptor desensitization, internalization and trafficking (in contrast to GRK2 and GRK3, which have the opposite effect).[9][10] This difference is one basis for pharmacological biased agonism (also called functional selectivity), where a drug binding to a receptor may bias that receptor’s signaling toward a particular subset of the actions stimulated by that receptor.[11][12] - https://en.wikipedia.org/wiki/GRK5 moda bind to DAT without touching beta-arrestine, this cause loss of beta-areestine mediated signaling, and also stop beta-arrestine mediated tolerance
Functional selectivity
Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signaling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor. Functional selectivity can be present when...
GRK5
G protein-coupled receptor kinase 5 is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases, and is most highly similar to GRK4 and GRK6. The protein phosphorylates the activated forms of G protein-coupled receptors to regulate their signaling.
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14:10
the result is a substance that have better tolerance profile but lack some of dopaminagic effect. (edited)
14:11
https://en.wikipedia.org/wiki/Modafinil
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Modafinil
Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant medication used to treat sleepiness due to narcolepsy, shift work sleep disorder, and obstructive sleep apnea. While it has seen off-label use as a purported cognitive enhancer to improve wakefulness in animal and human studies, the research o...
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SAGE（２０２２） 25-Aug-22 09:49 PM
@ibtisam.midlet do you know how to calculate mice dosage to human dosage conversion?
21:49
25 mg/kg in mice I want to know
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ibtisam.midlet 25-Aug-22 10:22 PM
~2mg/kg
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Pax1l
Topical deferoxamine may mitigate skin aging and ameliorate hair loss and greying
machineyadav 26-Aug-22 04:53 AM
I might experiment with this later
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machineyadav
I might experiment with this later
machineyadav 26-Aug-22 04:55 AM
I am troubled by thin skin
04:55
Particular high cortisol for prolonged period
04:55
Caused acne, oily skin and thin skin
04:56
Also pockmarks/acne scars from acne
04:56
Tret and isotretinoin combined doesn't work
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machineyadav
Also pockmarks/acne scars from acne
veganpermanently 26-Aug-22 05:39 AM
one made up word: microneedling
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veganpermanently
one made up word: microneedling
machineyadav 26-Aug-22 05:46 AM
I know it helps
05:47
But main issue is thin skin
05:47
Then acne and acne scars
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machineyadav
Also pockmarks/acne scars from acne
Yana 26-Aug-22 06:35 AM
I am of pockmarked shapes, the vermin you need to loathe
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Yana 26-Aug-22 07:48 AM
@veganpermanently Thoughts on oysters/ostroveganism
07:51
People like to say they have no nervous system but like they do (edited)
07:51
too advanced for me
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Yana
People like to say they have no nervous system but like they do (edited)
veganpermanently 26-Aug-22 08:20 AM
They do have a nervous system but it's very simple, consist of a pair of ganglia and they don't have a CNS. Some are mobile, some are sessile, for this reason ostrovegans eat only oysters and mussels while bivalvegans eat all of the bivalves. As a child I used to spend hours collecting these creatures from the seafloor, after I came home they would move around the table seemingly trying to find a way back to the sea. It's unclear if this is simply a muscular response or if the animals are capable of feeling the desire to return back to the sea. They may experience nociception but are unlikely to be traumatized by it, comprehend the event of relocation or the fact that their life may end because they lack a CNS. In other words, they're unlikely to feel the complex emotion of pain
08:22
TLDR I think these people are vegans
08:23
it would be cool to gene modify oysters to omit the ganglia too then it would be sure they don't experience anything
08:23
just meat growing on an underwater rock
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veganpermanently
it would be cool to gene modify oysters to omit the ganglia too then it would be sure they don't experience anything
Yana 26-Aug-22 08:26 AM
Pretty much lab-grown meat less scientifically advanced edition
08:27
Which is even better... It's not like muscle meat they're growing is some kind of superfood. Seems kinda pointless though I'd rather die than eat impossible burger
08:29
Idk it's a weird one and pretty much reminds me of scientific discussions on consciousness how it never comes to a definitive conclusion
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Yana
Idk it's a weird one and pretty much reminds me of scientific discussions on consciousness how it never comes to a definitive conclusion
veganpermanently 26-Aug-22 08:40 AM
Yeah it's hard to draw a line but people get ridiculous about it. My father spat the idea that atoms are conscious as an argument against veganism. I left the bar and never talked to him again. In these situations common sense needs to be applied but people would rather justify their current way of life by relativizing or go to other extremes like one of my friends stopped eating altogether because he was convinced plants feel pain. I can't deal with these people
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Yana
Which is even better... It's not like muscle meat they're growing is some kind of superfood. Seems kinda pointless though I'd rather die than eat impossible burger
veganpermanently 26-Aug-22 08:43 AM
btw there is nothing in oysters that plants cannot provide. Active B12 is present in water lentils, even chlorella has small amounts. Omega 3 is more available from ALA due to blood brain transport. Vegans have the same levels of serum zinc and copper as omnivores despite the decreased dietary intake ratio, probably due to homeostasis regulation and Cu chelation by isoflavones.
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veganpermanently
Yeah it's hard to draw a line but people get ridiculous about it. My father spat the idea that atoms are conscious as an argument against veganism. I left the bar and never talked to him again. In these situations common sense needs to be applied but people would rather justify their current way of life by relativizing or go to other extremes like one of my friends stopped eating altogether because he was convinced plants feel pain. I can't deal with these people
Yana 26-Aug-22 08:47 AM
Based breatharian
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veganpermanently
btw there is nothing in oysters that plants cannot provide. Active B12 is present in water lentils, even chlorella has small amounts. Omega 3 is more available from ALA due to blood brain transport. Vegans have the same levels of serum zinc and copper as omnivores despite the decreased dietary intake ratio, probably due to homeostasis regulation and Cu chelation by isoflavones.
Yana 26-Aug-22 08:47 AM
Wdym homeostasis regulation
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Yana
Based breatharian
veganpermanently 26-Aug-22 08:47 AM
Dude turned into a frail stick
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Yana 26-Aug-22 08:48 AM
Why would chelation of divalent metals maintain high zinc/copper unless at the expense of something else like iron
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Yana
Wdym homeostasis regulation
veganpermanently 26-Aug-22 08:48 AM
well I would presume there is some feedback and the body can regulate absorption to a degree
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veganpermanently
well I would presume there is some feedback and the body can regulate absorption to a degree
Yana 26-Aug-22 08:48 AM
Do you think this has potential to get out of whack on an oimnivorous diet
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veganpermanently 26-Aug-22 08:49 AM
Zinc intake is lower in vegans, while copper is way higher, yet the serum levels are the same as in omnivores
08:49
zinc and copper compete for absorption, but I think it's way more nuanced than this
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Yana 26-Aug-22 08:50 AM
Ah yes I thought copper was low on vegan diet for some reason... maybe that's carnivore
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veganpermanently 26-Aug-22 08:51 AM
there is no shortage of that roflmao. manganese as well
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Yana 26-Aug-22 08:51 AM
Zinc causes buildup of metallothionein which chelates copper in stomach
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veganpermanently 26-Aug-22 08:51 AM
I have trouble maintaining them below the recommended limit (edited)
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Yana
Zinc causes buildup of metallothionein which chelates copper in stomach
veganpermanently 26-Aug-22 08:52 AM
I think there's more stuff like this science is yet to uncover
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Yana 26-Aug-22 08:53 AM
With all the chelators present in plant foods I would think regulating the enzymes that break them down like phytase would be a big part of herbivore metabolism as opposed to blocking uptake like with ferroportin or heme carrier proteins
08:54
I think having this enzyme would be net negative
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Yana
With all the chelators present in plant foods I would think regulating the enzymes that break them down like phytase would be a big part of herbivore metabolism as opposed to blocking uptake like with ferroportin or heme carrier proteins
veganpermanently 26-Aug-22 08:56 AM
nice
08:56
I gotta dip talk to you later
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Yana 26-Aug-22 09:12 AM
https://pubmed.ncbi.nlm.nih.gov/19280374/
The plasma zinc/serum copper ratio as a biomarker in children with ...
The frequency of zinc deficiency, copper toxicity and low zinc/copper in children with autism spectrum disorders (ASDs) may indicate decrement in metallothionein system functioning. A retrospective review of plasma zinc, serum copper and zinc/copper was performed on data from 230 children with autis …
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Yana
People like to say they have no nervous system but like they do (edited)
Netizenne 26-Aug-22 11:49 AM
Bet plants have some equivalent of a stress signalling system
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veganpermanently
it would be cool to gene modify oysters to omit the ganglia too then it would be sure they don't experience anything
Netizenne 26-Aug-22 11:51 AM
At that point may as well breed cows with omitted ganglia lol
11:51
Kinda unrelated but have you read hitchhikers guide to the galaxy?? There’s a scene where the waiters at a restaurants are the very cows the people are gonna eat lol. I think they were bred / engineered to really get off on the idea of it or something. (edited)
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veganpermanently
Yeah it's hard to draw a line but people get ridiculous about it. My father spat the idea that atoms are conscious as an argument against veganism. I left the bar and never talked to him again. In these situations common sense needs to be applied but people would rather justify their current way of life by relativizing or go to other extremes like one of my friends stopped eating altogether because he was convinced plants feel pain. I can't deal with these people
Netizenne 26-Aug-22 11:54 AM
Oh lol rip what’ve I done Wuhhhh
11:54
Tbf it is kinda fun to get into the debate of concioussness tho
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Netizenne
At that point may as well breed cows with omitted ganglia lol
veganpermanently 26-Aug-22 12:03 PM
how are they going to grow up without a brain? Also it's a lot of unnecessary tissues like organs etc. Bivalve without the ganglia is pure meat growing on a rock eating blue green algae
12:03
very economical
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veganpermanently
how are they going to grow up without a brain? Also it's a lot of unnecessary tissues like organs etc. Bivalve without the ganglia is pure meat growing on a rock eating blue green algae
Netizenne 26-Aug-22 09:33 PM
I think like how they raise veil could work
21:34
Might need feeding tubes and stuff tho
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Netizenne
Bet plants have some equivalent of a stress signalling system
blank 27-Aug-22 08:29 AM
they even use some of the same neurotransmitters as us it's pretty crazy
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Levi 27-Aug-22 01:57 PM
emoji_52
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JUNGLE | Toasty 27-Aug-22 01:58 PM
hey guys what is the effective way to take phenibut to not build tolerance
13:58
taking it every 3rd day right now
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Levi
emoji_52
veganpermanently 27-Aug-22 01:59 PM
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JUNGLE | Toasty
hey guys what is the effective way to take phenibut to not build tolerance
veganpermanently 27-Aug-22 01:59 PM
not taking it
13:59
or take it with a pinch of salt
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veganpermanently
Click to see attachment 🖼️
Levi 27-Aug-22 01:59 PM
You're here emoji_52
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Netizenne
Bet plants have some equivalent of a stress signalling system
Man2 27-Aug-22 02:00 PM
i like eating things that feel pain
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Levi 27-Aug-22 02:00 PM
Wait are you the real one
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Levi
Wait are you the real one
veganpermanently 27-Aug-22 02:00 PM
yes
14:00
when we're talking about salt
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Levi 27-Aug-22 02:00 PM
Blue wine or red wine
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veganpermanently 27-Aug-22 02:00 PM
I should go salt my bird's tail
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Levi
Blue wine or red wine
veganpermanently 27-Aug-22 02:01 PM
red is an indication of acidity
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Levi 27-Aug-22 02:01 PM
Ok you're the real one
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veganpermanently 27-Aug-22 02:02 PM
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Original message was deleted or could not be loaded.
veganpermanently 27-Aug-22 02:03 PM
u should change your nick to roofies
14:03
because that's the only way you can loose your virginity
14:04
@Levi yo why is everyone asking me if I'm VP
14:05
do I have impersonators or what
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Levi 27-Aug-22 02:05 PM
I thought you left discord because your old account is deleted
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veganpermanently 27-Aug-22 02:05 PM
oh mkay
14:05
btw
14:05
r u in bio.hax
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Levi 27-Aug-22 02:05 PM
Yeah
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veganpermanently 27-Aug-22 02:06 PM
k cheers
14:06
have a good one I'm about to sleep
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Levi 27-Aug-22 02:06 PM
Sleep well
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veganpermanently 27-Aug-22 02:06 PM
tnx I'll need it
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Man2
i like eating things that feel pain
Netizenne 27-Aug-22 02:07 PM
What if there was a gene for masochism ????
14:08
We don’t even really need to breed the consciousness out of them, can just get rid of their awareness of the situation
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Netizenne
What if there was a gene for masochism ????
Doctor Bonk 27-Aug-22 02:10 PM
and what if we have it! emoji_50
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Netizenne
We don’t even really need to breed the consciousness out of them, can just get rid of their awareness of the situation
Man2 27-Aug-22 02:11 PM
yeah consciousness exists at all levels of matter no getting rid of that
14:12
i dont cows are very aware
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Netizenne 27-Aug-22 02:35 PM
https://broadblogs.com/2010/11/04/men-aren%E2%80%99t-hard-wired-to-find-breasts-attractive/
BroadBlogs
Men Aren’t Hard Wired To Find Breasts Arousing
Men aren’t hard wired to find breasts arousing? No. And how do we know this? The same way we discover that many things aren’t biologically-based. By learning about other cultures. And the breast fe…
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TreeSlayer 27-Aug-22 02:52 PM
"with images of a nude woman creating greater blood flow to the vaginal area than images of a nude man"
14:52
Hmm
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veganpermanently
not taking it
snekborg 27-Aug-22 04:02 PM
facts
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Netizenne
https://broadblogs.com/2010/11/04/men-aren%E2%80%99t-hard-wired-to-find-breasts-attractive/
snekborg 27-Aug-22 04:03 PM
its not the nipple part tho its the cleavage part emoji_49
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Netizenne 27-Aug-22 04:20 PM
https://mad.science.blog/2021/05/20/do-psychedelics-produce-illusions-by-inducing-night-vision/
theschizotypal
Do Psychedelics Produce Illusions By Inducing Night Vision?
Some of the mechanisms behind darkness adaptation overlap with illusory motion. These mechanisms may be tied to the mechanisms of psychedelic drugs. It may be that psychedelics amplify an endogenou…
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The Duke of Wellington 27-Aug-22 04:34 PM
Na
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The Blur 27-Aug-22 04:35 PM
People still do this? lol
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Pax1l 27-Aug-22 04:35 PM
@admin
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Levi 27-Aug-22 04:35 PM
Chill out
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MEE6 BOT 27-Aug-22 04:35 PM
@Levi, you have advanced to lvl 1 respect++ emoji_51
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The Blur 27-Aug-22 04:35 PM
Who the fuck is Wufus you dumb fuck @Rufus
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Pax1l 27-Aug-22 04:35 PM
@super mod
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The Blur 27-Aug-22 04:35 PM
Like give us context
16:35
Yikes
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Levi 27-Aug-22 04:36 PM
He got banned at sirsad server
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blank 27-Aug-22 04:36 PM
@Lux ✨ @Potential
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The Blur 27-Aug-22 04:36 PM
Hate to break it to you but SirMad eats McDonald’s @Rufus
🤣 1
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TreeSlayer
"with images of a nude woman creating greater blood flow to the vaginal area than images of a nude man"
Odder_Sea (Glowie) 27-Aug-22 04:37 PM
Can confirm, cleavage makes me moist
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Pax1l 27-Aug-22 04:37 PM
Dude honestly get a fucking life
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MEE6 BOT 27-Aug-22 04:37 PM
@Rufus, you have advanced to lvl 1 respect++ emoji_51
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The Blur 27-Aug-22 04:38 PM
Why is Pax shit? @Rufus
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Pax1l 27-Aug-22 04:38 PM
Maybe the reason youre banned is because youre too fucking stupid to make an alt account
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Pax1l
Maybe the reason youre banned is because youre too fucking stupid to make an alt account
blank 27-Aug-22 04:39 PM
he already made a few but he's trolling is so obvious he keeps getting banned
16:39
why the fuck does this server have no mods
😂 2
16:39
he's literally spamming the entire chat with n word then comes here to beg for unban
16:39
...
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blank
he's literally spamming the entire chat with n word then comes here to beg for unban
The Blur 27-Aug-22 04:40 PM
When has he said the n word?
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blank 27-Aug-22 04:40 PM
he harassed everyone's dms in nootopics for like weeks just to get unabnned
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blank
he's literally spamming the entire chat with n word then comes here to beg for unban
Odder_Sea (Glowie) 27-Aug-22 04:40 PM
I don't think he ever actually used the n word
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blank
why the fuck does this server have no mods
Pax1l 27-Aug-22 04:40 PM
Because @ibtisam.midlet just has no clue how to run a server
despair 1
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MEE6 BOT 27-Aug-22 04:40 PM
@Pax1l, you have advanced to lvl 4 respect++ emoji_51
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Man2 27-Aug-22 04:40 PM
just block him
16:40
fuk
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Odder_Sea (Glowie)
I don't think he ever actually used the n word
blank 27-Aug-22 04:40 PM
1 or 2 g's doesn't really matter the intent is clear
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The Blur 27-Aug-22 04:41 PM
this kind of stuff never happens at WaterWellness, just saying
😂 1
👍 1
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Man2 27-Aug-22 04:41 PM
he gone
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The Blur
this kind of stuff never happens at WaterWellness, just saying
blank 27-Aug-22 04:41 PM
tf is waterwellness
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blank
tf is waterwellness
The Blur 27-Aug-22 04:41 PM
My server 🤣
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The Blur
My server 🤣
blank 27-Aug-22 04:42 PM
can I haz unbanish 🙏🏽
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The Blur
this kind of stuff never happens at WaterWellness, just saying
Man2 27-Aug-22 04:42 PM
send invite?
16:42
or is it paxes server ?
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blank 27-Aug-22 04:42 PM
did someone finally revive it
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JUNGLE | Toasty 27-Aug-22 04:42 PM
sorry idiot from our discord server escaped
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The Blur
My server 🤣
Netizenne 27-Aug-22 04:42 PM
You should really put your server in your discord bio at the bare minimum tbh
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JUNGLE | Toasty 27-Aug-22 04:42 PM
reached your server
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blank
can I haz unbanish 🙏🏽
The Blur 27-Aug-22 04:42 PM
Didn’t u do the same thing thinkW
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Man2
or is it paxes server ?
Odder_Sea (Glowie) 27-Aug-22 04:42 PM
Bio-tolerance
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Odder_Sea (Glowie)
Bio-tolerance
Man2 27-Aug-22 04:42 PM
no waterwellness
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Netizenne 27-Aug-22 04:42 PM
Mb guys rip
🥚 3
eSobbing 1
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Netizenne
Mb guys rip
Doctor Bonk 27-Aug-22 04:43 PM
emoji_13
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The Blur
this kind of stuff never happens at WaterWellness, just saying
Odder_Sea (Glowie) 27-Aug-22 04:43 PM
Waterwellness it is. Invite?
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The Blur 27-Aug-22 04:43 PM
everyone click the link in my bio to join AYS_Sparkles WaterWellness AYS_Sparkles
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Levi 27-Aug-22 04:44 PM
Waterwellness is blur's server
16:44
Not pax
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Man2 27-Aug-22 04:44 PM
pog paxs is full of scammers who dm u
🧢 1
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The Blur
Didn’t u do the same thing thinkW
blank 27-Aug-22 04:44 PM
I don't even remember anymore
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blank
I don't even remember anymore
The Blur 27-Aug-22 04:44 PM
unbanned
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blank 27-Aug-22 04:45 PM
🕴️
👀 5
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Man2
pog paxs is full of scammers who dm u
Pax1l 27-Aug-22 04:46 PM
Youre not a member of my server
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machineyadav 27-Aug-22 05:34 PM
Wtf
17:34
,pings
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Yana 27-Aug-22 06:01 PM
https://www.youtube.com/playlist?list=PLwCIO0axV4qZKUvYJxpXqGhYMBsIWoUOQ
Nutritarian Bodybuilder Diet Series
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ibtisam.midlet 27-Aug-22 07:02 PM
Imagine giving all members banning power??
19:03
everyone will ban his anxiety trigger
19:03
Anyway, thanks @Netizenne
19:07
Who you would ban between @everyone
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Man2
pog paxs is full of scammers who dm u
Odder_Sea (Glowie) 27-Aug-22 07:17 PM
I have never had anyone on @Pax1l's server PM or try to sell me anything
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snekborg 27-Aug-22 07:21 PM
im in vc
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Netizenne
https://mad.science.blog/2021/05/20/do-psychedelics-produce-illusions-by-inducing-night-vision/
ibtisam.midlet 27-Aug-22 07:28 PM
Yeah Ht2a expressed on eyes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340756/
5-hydroxytryptamine level and 5-HT2A receptor mRNA expression in th...
To investigate 5-hydroxytryptamine (5-HT) function and 5-HT receptor 2A (5-HT2A) mRNA expression in the formation of lens-induced myopia (LIM).Lens-induced myopia construction method was applied to generate myopia on guinea pig right eye (LIM eye).LIM ...
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19:30
Making expression pattern for all receptors would be neat
19:31
I'll just need to scrap all Wikipedia pages side bar
19:31
@Netizenne do you think its good idea to focus on it right now
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ibtisam.midlet
Who you would ban between @everyone
blank 27-Aug-22 08:51 PM
randomly delete half of the server emoji_49
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ibtisam.midlet
I'll just need to scrap all Wikipedia pages side bar
Netizenne 27-Aug-22 08:52 PM
Most active servers have very few channels and keep things simple
20:52
But idk
20:52
Maybe you should make a new server instead of deleting everything if your gonna try a simpler design (edited)
20:53
I’d hate to see it all gone :/
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ibtisam.midlet 27-Aug-22 09:02 PM
Server activity related to casual
21:02
even if other channels being active
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ibtisam.midlet 27-Aug-22 09:47 PM
a girl blocked me lol
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MEE6 BOT 27-Aug-22 09:47 PM
@ibtisam.midlet, you have advanced to lvl 15 respect++ emoji_51
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ibtisam.midlet 27-Aug-22 09:58 PM
Image attachment
22:00
Its from complexity server someone go simp her
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friday 27-Aug-22 10:13 PM
hi
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friday
hi
ibtisam.midlet 27-Aug-22 10:17 PM
Hiii 😍😍😍
22:17
Wanna talk in DMs??
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friday 27-Aug-22 10:18 PM
ok add me
22:19
also i have a penis
💟 1
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Odder_Sea (Glowie) 27-Aug-22 11:03 PM
🥰
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RentableZulu 27-Aug-22 11:05 PM
First time back in months and this is the exchange I see. “Also, I have a penis” literally gold 😂
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Netizenne
https://broadblogs.com/2010/11/04/men-aren%E2%80%99t-hard-wired-to-find-breasts-attractive/
veganpermanently 27-Aug-22 11:48 PM
I was thinking the other day. It's prolly a kink
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RentableZulu
First time back in months and this is the exchange I see. “Also, I have a penis” literally gold 😂
Odder_Sea (Glowie) 27-Aug-22 11:48 PM
Extra special
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veganpermanently
I was thinking the other day. It's prolly a kink
Odder_Sea (Glowie) 27-Aug-22 11:49 PM
...probably? emoji_4
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veganpermanently
I was thinking the other day. It's prolly a kink
Netizenne 28-Aug-22 12:03 AM
Normal sexual attraction and orientations probably share the same (or a very similar) underlying mechanism of cultural ingraining as the warped and trans and etc.
00:04
Aka is it all just fetishes underneath? (edited)
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Blossoming Tree of Peace 28-Aug-22 12:06 AM
I'm back
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Netizenne 28-Aug-22 12:13 AM
Hello back, I’m neti
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Netizenne
Normal sexual attraction and orientations probably share the same (or a very similar) underlying mechanism of cultural ingraining as the warped and trans and etc.
veganpermanently 28-Aug-22 12:24 AM
I think the only normal sexual attraction is being attracted to the whole person not it's body parts or even personality parts, actions-reactions, etc. Anything too specific is a fetish IMO. The point is reproduction therefore why would one want to carry on the genes of a boob and not much else
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veganpermanently
I think the only normal sexual attraction is being attracted to the whole person not it's body parts or even personality parts, actions-reactions, etc. Anything too specific is a fetish IMO. The point is reproduction therefore why would one want to carry on the genes of a boob and not much else
Netizenne 28-Aug-22 12:30 AM
I think the principle of fetishization is normal and it’s just the sorts of fetishes that people develop that differ (edited)
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Netizenne
I think the principle of fetishization is normal and it’s just the sorts of fetishes that people develop that differ (edited)
veganpermanently 28-Aug-22 12:31 AM
well in a mouse utopia sure
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MEE6 BOT 28-Aug-22 12:31 AM
@veganpermanently, you have advanced to lvl 8 respect++ emoji_51
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Netizenne 28-Aug-22 12:32 AM
how do you fix someone incapable of love
00:32
?!?!???????????
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Blossoming Tree of Peace 28-Aug-22 12:32 AM
I have a document for this one lol
00:32
Assuming you mean narcissism is the reason why
00:32
But I don't have a fix yet
00:33
Many of the brain regions disturbed/deviating from the norm have been identified
00:33
So I think just fix those?
00:34
Brain connectivity between regions is also fucked, so NSI-189 for that
00:34
But idk how to assess each region
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veganpermanently 28-Aug-22 12:34 AM
NGF
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Blossoming Tree of Peace 28-Aug-22 12:34 AM
Bacopa
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veganpermanently 28-Aug-22 12:34 AM
NGF BDNF GDNF
00:35
NA DA 5HT
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Blossoming Tree of Peace 28-Aug-22 12:35 AM
Narcissists need bacopa
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veganpermanently 28-Aug-22 12:35 AM
ascorbate
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Blossoming Tree of Peace 28-Aug-22 12:35 AM
Can we actually treat Narcissism tho
00:35
Is it possible
00:35
There's been 0 success so far
00:35
I like a challenge tho
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veganpermanently 28-Aug-22 12:35 AM
IDK
00:36
feels like they don't want to be fixed
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Blossoming Tree of Peace 28-Aug-22 12:36 AM
Just don't want to waste time on one that can't be conquered
00:36
Yea but what if the narcissism is caused by ALS
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MEE6 BOT 28-Aug-22 12:36 AM
@Blossoming Tree of Peace, you have advanced to lvl 1 respect++ emoji_51
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Blossoming Tree of Peace 28-Aug-22 12:36 AM
There's evidence of this
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veganpermanently 28-Aug-22 12:36 AM
narcissim is much like addicion IMO
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Blossoming Tree of Peace 28-Aug-22 12:36 AM
It really is
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veganpermanently 28-Aug-22 12:37 AM
if the person doesn't recognize the dependency there is no chance of recovery
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veganpermanently
narcissim is much like addicion IMO
Netizenne 28-Aug-22 12:37 AM
NAC
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Blossoming Tree of Peace 28-Aug-22 12:37 AM
Hmm I'll try and cure addiction first, bc I'm an addict
00:37
I take nac daily
00:37
Doesn't help much there
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veganpermanently
narcissim is much like addicion IMO
CEO 28-Aug-22 12:37 AM
D-serine
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Blossoming Tree of Peace 28-Aug-22 12:37 AM
Didn't help me
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Netizenne 28-Aug-22 12:37 AM
L-theanine!!!!
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Blossoming Tree of Peace 28-Aug-22 12:37 AM
Caused bad headaches too
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Netizenne
L-theanine!!!!
Blossoming Tree of Peace 28-Aug-22 12:37 AM
Lmfao
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Netizenne
NAC
veganpermanently 28-Aug-22 12:37 AM
NAC Memantine and Naltrexone. my theoretical stack for addiction
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Blossoming Tree of Peace 28-Aug-22 12:38 AM
Tried it
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CEO
D-serine
veganpermanently 28-Aug-22 12:38 AM
D-aspartate
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Blossoming Tree of Peace 28-Aug-22 12:38 AM
I've tried everything, but looking at addiction as a singular will get you nowhere
00:38
You have to look at why the person is an addict
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Blossoming Tree of Peace
I've tried everything, but looking at addiction as a singular will get you nowhere
veganpermanently 28-Aug-22 12:38 AM
you haven't tried my stack
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Blossoming Tree of Peace
You have to look at why the person is an addict
Netizenne 28-Aug-22 12:39 AM
Past conditioning maybe
00:39
With behavioural addictions that’s the case
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Blossoming Tree of Peace 28-Aug-22 12:39 AM
I've tried nac mem and naltrexone combined for months lol
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veganpermanently 28-Aug-22 12:39 AM
Memantine alone solved all of my addictions so I don't even need the wider stack
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veganpermanently
D-aspartate
CEO 28-Aug-22 12:39 AM
What do you recommend for obsessive and intrusive thoughts
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Blossoming Tree of Peace
I've tried nac mem and naltrexone combined for months lol
veganpermanently 28-Aug-22 12:39 AM
oh rly
00:39
what doses
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Netizenne
With behavioural addictions that’s the case
Netizenne 28-Aug-22 12:39 AM
Sirsad talks about it in terms of sensitization
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Blossoming Tree of Peace 28-Aug-22 12:39 AM
Yes
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veganpermanently 28-Aug-22 12:39 AM
what r u addicted to
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Netizenne 28-Aug-22 12:40 AM
Dreams
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Blossoming Tree of Peace 28-Aug-22 12:40 AM
100 mg mem daily (ik it's a lot and could fault rhe anecdote), 2400 mg nac in multiple doses, 50 mg naltrexone daily
00:40
I've tried other forms of the stack but dif doses as well, just not for as lengthy of times
00:41
I'm addicted to everything p much
00:41
My addiction stems from health issues
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Netizenne 28-Aug-22 12:42 AM
efggg
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veganpermanently 28-Aug-22 12:42 AM
powerful
00:42
Neti
00:42
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Blossoming Tree of Peace 28-Aug-22 12:42 AM
I'll cure addiction
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veganpermanently 28-Aug-22 12:43 AM
100 mg Memantine wtf
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Blossoming Tree of Peace 28-Aug-22 12:43 AM
Autisms
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veganpermanently 28-Aug-22 12:43 AM
how were you functioning
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Blossoming Tree of Peace 28-Aug-22 12:43 AM
It helped my adhd lol
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veganpermanently 28-Aug-22 12:43 AM
like were you not M holing all the time
00:43
roflmao
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Blossoming Tree of Peace 28-Aug-22 12:43 AM
I've written a lab report on 300 mg mem w no tolerance before
00:44
I got a 96
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veganpermanently 28-Aug-22 12:44 AM
bruh
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Blossoming Tree of Peace 28-Aug-22 12:45 AM
I'm a fucking anomaly in every regard
00:45
Hence why I have to figure everything out myself
00:45
Bc other people's suggestions are just not comprehensive enough, ever
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Blossoming Tree of Peace
I'm a fucking anomaly in every regard
Netizenne 28-Aug-22 12:45 AM
Do you bleed ?
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Netizenne
Do you bleed ?
veganpermanently 28-Aug-22 12:46 AM
I don't bleed I piss out of my veins
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Blossoming Tree of Peace 28-Aug-22 12:46 AM
I have adhd, autism, depression, anxiety, probable bipolar, anhedonia, severe health issues etc
00:46
I need the most comprehensive approach possible if i want to get better
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veganpermanently 28-Aug-22 12:48 AM
I've never been diagnosed with anything thank God
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Blossoming Tree of Peace 28-Aug-22 12:48 AM
Rapamycin has been the most helpful thing for me yet
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MEE6 BOT 28-Aug-22 12:48 AM
@Blossoming Tree of Peace, you have advanced to lvl 2 respect++ emoji_51
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veganpermanently 28-Aug-22 12:48 AM
u snort rapa?
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Blossoming Tree of Peace 28-Aug-22 12:48 AM
Brings me back to childhood like state bc autoimmunity is assessed
00:48
I did snort it initially
00:49
But I've been trying oral lately
00:49
I dose every 3 days or so
00:49
Bc it's pretty hypertensive and I have brain hypertension too!
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veganpermanently 28-Aug-22 12:49 AM
ye I found oral effects better
00:49
less sides
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Blossoming Tree of Peace 28-Aug-22 12:49 AM
Oral is more leveled
00:50
It's appetite suppression is significant tho
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veganpermanently 28-Aug-22 12:50 AM
btw how do you be addicted to everything and take the supplements too
00:50
you just consume all day?
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Blossoming Tree of Peace 28-Aug-22 12:50 AM
I make money too lmfao
00:50
Yea
00:51
I don't really have an issue w consuming things lol
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veganpermanently 28-Aug-22 12:51 AM
like what
00:51
cannabis
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Blossoming Tree of Peace 28-Aug-22 12:51 AM
I toss and wash everything
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veganpermanently 28-Aug-22 12:51 AM
opiates
00:51
benzos
00:51
alcohol
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Netizenne 28-Aug-22 12:51 AM
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Original message was deleted or could not be loaded.
veganpermanently 28-Aug-22 12:52 AM
nooo
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Blossoming Tree of Peace 28-Aug-22 12:52 AM
Cannabis, benzos, kratom (don't risk going to stronger stuff but have done hydros,, codeine and morphine), phenibut, gabapentin, and alcohol
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veganpermanently 28-Aug-22 12:52 AM
delete pls
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Blossoming Tree of Peace 28-Aug-22 12:52 AM
Alcohol is the hardest one for me
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veganpermanently 28-Aug-22 12:52 AM
thank u
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Blossoming Tree of Peace 28-Aug-22 12:52 AM
I quit everything else
00:52
But can't quit alcohol
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Blossoming Tree of Peace
Cannabis, benzos, kratom (don't risk going to stronger stuff but have done hydros,, codeine and morphine), phenibut, gabapentin, and alcohol
veganpermanently 28-Aug-22 12:52 AM
ooooff
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Blossoming Tree of Peace 28-Aug-22 12:53 AM
It's the accessibility and it helps me focus and put sentences together better
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veganpermanently 28-Aug-22 12:53 AM
no wonder the memNACnaltrexone doesn't help
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Blossoming Tree of Peace 28-Aug-22 12:53 AM
Memnacltrexone*
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Blossoming Tree of Peace
Memnacltrexone*
veganpermanently 28-Aug-22 12:53 AM
read in a hard scottish accent
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Netizenne 28-Aug-22 12:53 AM
I think there needs to be more research on the potential that western people’s biologies have adapted to an enviroment where there’s always a small amount of alcohol in the water supply, and how to best minimize that evolutionary mismatch between our evolved and current environment (edited)
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Blossoming Tree of Peace 28-Aug-22 12:54 AM
I think I read in a Scandinavian accent
00:54
Close enough
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Blossoming Tree of Peace
I think I read in a Scandinavian accent
veganpermanently 28-Aug-22 12:54 AM
I spat all of my mouth moisture on my desk reading it
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Blossoming Tree of Peace 28-Aug-22 12:55 AM
Yea so close enough then
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Netizenne
I think there needs to be more research on the potential that western people’s biologies have adapted to an enviroment where there’s always a small amount of alcohol in the water supply, and how to best minimize that evolutionary mismatch between our evolved and current environment (edited)
veganpermanently 28-Aug-22 12:56 AM
funnily enough I was always sensitive to alcohol but since I started neurotrophin maxxing I became absolutely intolerant
00:56
I can't drink a single drop
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Blossoming Tree of Peace 28-Aug-22 12:56 AM
I was buzzed from 2 drinks for 12 hrs my first times
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veganpermanently 28-Aug-22 12:57 AM
hate that high
00:57
makes me feel so stupid
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Blossoming Tree of Peace 28-Aug-22 12:57 AM
I love it bc it makes me smarter
00:57
Objectively
00:57
I've tested work performance on it
00:57
I'm a cook so its easy to test
00:58
Can I keep up or do I fall behind is all that needs to be tested
00:58
And I always keep up on alc
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Blossoming Tree of Peace
I'm a cook so its easy to test
veganpermanently 28-Aug-22 12:58 AM
that explains everything
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Blossoming Tree of Peace 28-Aug-22 12:58 AM
Sober I fall behind
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veganpermanently 28-Aug-22 12:58 AM
roflmao
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Netizenne 28-Aug-22 12:58 AM
In what ways might our biology have shifted around to adapt for an ever persistent alcohol intake
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veganpermanently 28-Aug-22 12:58 AM
tip for u
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Blossoming Tree of Peace 28-Aug-22 12:58 AM
Oh yea cooks have to be addicts
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veganpermanently 28-Aug-22 12:58 AM
if you wanna get rid of your addictions
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Blossoming Tree of Peace 28-Aug-22 12:58 AM
Get a new jib if I wanna be sober
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veganpermanently 28-Aug-22 12:58 AM
change your profession
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Blossoming Tree of Peace 28-Aug-22 12:58 AM
I'm aware
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veganpermanently 28-Aug-22 12:58 AM
😄
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Blossoming Tree of Peace 28-Aug-22 12:59 AM
Unfortunately none pay as well
00:59
I could gas station work but it'd be so boring I'd end up using more
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Blossoming Tree of Peace
I could gas station work but it'd be so boring I'd end up using more
veganpermanently 28-Aug-22 01:00 AM
delivery my guy
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Blossoming Tree of Peace 28-Aug-22 01:00 AM
My car kinda fucked rn
01:00
It'll drive but too much squeaky
01:01
I'd just drink while delivering and crash honestly
01:01
I need something I'm passionate about and has room for progression
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Blossoming Tree of Peace
I'd just drink while delivering and crash honestly
veganpermanently 28-Aug-22 01:02 AM
true
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Blossoming Tree of Peace 28-Aug-22 01:03 AM
It really doesn't matter what my job is
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MEE6 BOT 28-Aug-22 01:03 AM
@Blossoming Tree of Peace, you have advanced to lvl 3 respect++ emoji_51
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Blossoming Tree of Peace 28-Aug-22 01:04 AM
I'll drink there
01:04
So changing jobs won't fix the issue
01:04
I have to address the why
01:05
Even when I didn't work I drank daily before school
01:05
Anything that causes anxiety will make me want to, and every single job will cause anxiety in some fashion
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veganpermanently 28-Aug-22 01:05 AM
idk can't relate
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Blossoming Tree of Peace 28-Aug-22 01:05 AM
I'm aware
01:06
That's why I'm explaining my perspective
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veganpermanently 28-Aug-22 01:07 AM
I never even feel anxiety
01:07
in life threatening situations my body shakes yet my mind is collected
01:08
calmly persuade the robber while looking like I'm freezing at -20C
01:08
roflmao
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Blossoming Tree of Peace 28-Aug-22 01:08 AM
Jealous
01:08
Ive had severe anxiety every day of my life
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veganpermanently 28-Aug-22 01:09 AM
I've been dosed with caffeine since 5yrs old maybe that's why I'm like this
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veganpermanently
delivery my guy
Netizenne 28-Aug-22 01:09 AM
What’s the best paying driving type job?
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Netizenne
What’s the best paying driving type job?
veganpermanently 28-Aug-22 01:09 AM
trucker
01:10
drug mule
01:10
if u wanna go dark
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Netizenne 28-Aug-22 01:10 AM
I could become an ice trucker one day………. Waow
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veganpermanently 28-Aug-22 01:10 AM
met quite a few truckers that do both
01:10
it's easy to hide drugs in a truck full of random stuff
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Netizenne 28-Aug-22 01:10 AM
Ice road truckers can earn between $30,000 and $40,000 in just three months, making them some of the highest-paid drivers there are. However, this impressive salary comes at a cost. Ice road trucking can be a dangerous job.Feb 11, 2020
01:11
I think that’s good pay (edited)
01:11
Really I think I wanna maximize free time > pay tho
01:12
Pay would be nice tho cause then I can own a home on the coast with a garden
01:12
Idk what I’ll do
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Netizenne
Really I think I wanna maximize free time > pay tho
veganpermanently 28-Aug-22 01:12 AM
don't become a drug dealer then
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Netizenne
Ice road truckers can earn between $30,000 and $40,000 in just three months, making them some of the highest-paid drivers there are. However, this impressive salary comes at a cost. Ice road trucking can be a dangerous job.Feb 11, 2020
Netizenne 28-Aug-22 01:14 AM
Trucking seems like a potentially nice work balance Couple months of hard, methed out work then the rest of the year off (edited)
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MEE6 BOT 28-Aug-22 01:14 AM
@Netizenne, you have advanced to lvl 9 respect++ emoji_51
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Netizenne
Trucking seems like a potentially nice work balance Couple months of hard, methed out work then the rest of the year off (edited)
veganpermanently 28-Aug-22 01:15 AM
not a good idea to use illicits while trucking
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Netizenne 28-Aug-22 01:15 AM
They drug test a lot I’ve heard
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veganpermanently 28-Aug-22 01:15 AM
ye
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Netizenne 28-Aug-22 01:15 AM
I have adhd and a vyvanse script tho
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veganpermanently 28-Aug-22 01:15 AM
you need to sleep anyways
01:15
because it's enforced
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Netizenne
I have adhd and a vyvanse script tho
veganpermanently 28-Aug-22 01:16 AM
still makes no sense
01:16
they will catch you driving for more than allowed
01:16
it's heavily enforced at least here
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Netizenne 28-Aug-22 01:18 AM
Ya but Isn’t it really easy to focus on singular and boring things while on meth?
01:18
Actually what would be the ideal trucker stack lol
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Netizenne
Actually what would be the ideal trucker stack lol
veganpermanently 28-Aug-22 01:18 AM
lots of modafinil
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Blossoming Tree of Peace 28-Aug-22 01:36 AM
Probably
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Netizenne 28-Aug-22 03:31 AM
Hey @ibtisam.midlet , what do you think about biperiden, galantamine, and phenylpiracetam together?
03:31
Biperiden specifically, is it very dangerous? Could galantamine help balance it?
03:32
… Biperiden is a FIASMA (which I have reason to believe is good) It also blocks M1 (which your site suggests it’s agonism can block WM). (edited)
03:35
Galantamine is a positive allosteric modulator of a4b2 -the receptor phenylpiracetam agonizes for its effects. Phenyl has been one of my all time favourite noots tbh
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Netizenne
Do you bleed ?
Doctor Bonk 28-Aug-22 03:50 AM
emoji_51
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MEE6 BOT 28-Aug-22 03:50 AM
@Doctor Bonk, you have advanced to lvl 1 respect++ emoji_51
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Netizenne
… Biperiden is a FIASMA (which I have reason to believe is good) It also blocks M1 (which your site suggests it’s agonism can block WM). (edited)
veganpermanently 28-Aug-22 04:36 AM
Embedded image
04:37
Galantamine PP memantine hybrid drugs lesss gooo
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Netizenne 28-Aug-22 04:38 AM
https://www.reddit.com/r/Nootropics/comments/8h3h9l/how_to_increase_orexin/?utm_source=share&utm_medium=ios_app&utm_name=iossmf a4b2 and galantamine increase orexin???? (edited)
r/Nootropics - How To Increase Orexin
28 votes and 7 comments so far on Reddit
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04:40
https://www.reddit.com/r/Nootropics/comments/jpf1p5/nicotinic_receptor_positive_allosteric_modulator/?utm_source=share&utm_medium=ios_app&utm_name=iossmf Some other highlights on galantamines pharmacology
r/Nootropics - Nicotinic Receptor: Positive Allosteric Modulator + ...
53 votes and 17 comments so far on Reddit
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Netizenne
Biperiden specifically, is it very dangerous? Could galantamine help balance it?
ibtisam.midlet 28-Aug-22 04:40 AM
-Very dangerous Nope, I'm long term user of anti muscarine, I'm fine -Could glantamine help balance it ofc -Biperiden is fiasma Biperiden ic50 1.44 on M1 Give me ic50 on fiasma ill give the dose need to archive noticeable effect as fiasma
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Netizenne
… Biperiden is a FIASMA (which I have reason to believe is good) It also blocks M1 (which your site suggests it’s agonism can block WM). (edited)
ibtisam.midlet 28-Aug-22 04:40 AM
The right part is "when antagonising"
04:41
You spcitial memory problem
04:41
Which blockage on M1 will worsn it
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ibtisam.midlet
-Very dangerous Nope, I'm long term user of anti muscarine, I'm fine -Could glantamine help balance it ofc -Biperiden is fiasma Biperiden ic50 1.44 on M1 Give me ic50 on fiasma ill give the dose need to archive noticeable effect as fiasma
Netizenne 28-Aug-22 04:41 AM
Actually your probably a good person to ask, but in your opinion what’s the best way to inhibit the enzyme sphingomyelinase? (Or to reduce ceramide)
💟 1
04:45
Gotta sleep gnn
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ibtisam.midlet 28-Aug-22 04:54 AM
https://www.wikipathways.org/index.php/Pathway:WP5194
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ibtisam.midlet 28-Aug-22 05:31 AM
studies label substance as inhibitor even if its selectivity less then x100 (which means you will need x100 times the therapy dose of biperiden for Parkinson) to noticeably get effect on ceramide
05:33
searching for fiasma IC50 of biperiden found no result, do you have result for any other fiasma?
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ibtisam.midlet 28-Aug-22 05:51 AM
the other way is inhibiting Dihydroceramide desaturase (dihydroceramide into ceramide)
05:51
Cyclopropene Analogues of Ceramide, are Potent Inhibitor of Dihydroceramide Desaturase, they cause the enzyme to catalyze them instead of dihydroceramide, acting as competitive inhibitor
05:51
Dihydroceramide desaturase was inhibited by dithiothreitol, which suggests that it might be possible to alter ceramide synthesis
05:51
https://www.sciencedirect.com/science/article/pii/S0021925819659120
Characterization of Ceramide Synthesis: A DIHYDROCERAMIDE DESATURAS...
Ceramide (N-acylsphingosine) biosynthesis has been proposed to involve introduction of the 4,5-trans-double bond of sphingosine after synthesis of dih…
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ibtisam.midlet
Cyclopropene Analogues of Ceramide, are Potent Inhibitor of Dihydroceramide Desaturase, they cause the enzyme to catalyze them instead of dihydroceramide, acting as competitive inhibitor
ibtisam.midlet 28-Aug-22 05:53 AM
https://core.ac.uk/download/42338341.pdf
05:53
its easier to find inhibitors for this
05:55
the best way is mixing fiasma + Dihydroceramide desaturase and you get superior result , if ceramid was 20 (fiasma)>>5(Dihydroceramide desaturase)>>1.25
05:56
this cause none selective substance start giving potent effect
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ibtisam.midlet 28-Aug-22 06:23 AM
@CheckOnGoogleScholar unban me mr confident emoji_24, i promise will not act scum (or disrupt your plans)
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Netizenne
Actually your probably a good person to ask, but in your opinion what’s the best way to inhibit the enzyme sphingomyelinase? (Or to reduce ceramide)
ibtisam.midlet 28-Aug-22 07:43 AM
this list inhibitors for that https://www.bindingdb.org/rwd/bind/AdvancedSearch.jsp?sources=0&sources=1&sources=2&sources=3&sources=4&sources=5&sources=6&criteria=&choices=target_name%3A0%3A0%3A0&tn_name%3A0=contains&tn_text%3A0=sphingomyelinase try to filter one being clinically available
AdvancedSearch
Protein-Ligand Binding and Molecular Recognition Database
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ibtisam.midlet
this list inhibitors for that https://www.bindingdb.org/rwd/bind/AdvancedSearch.jsp?sources=0&sources=1&sources=2&sources=3&sources=4&sources=5&sources=6&criteria=&choices=target_name%3A0%3A0%3A0&tn_name%3A0=contains&tn_text%3A0=sphingomyelinase try to filter one being clinically available
Netizenne 28-Aug-22 12:56 PM
They are all highly experimental, nameless and random research chemicals despair
😂 2
12:58
https://open.spotify.com/track/44l2QraBH96L5LejzEFWLH?si=Kj8mztNwSp-OZzVXcLg6CA
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Netizenne
They are all highly experimental, nameless and random research chemicals despair
veganpermanently 28-Aug-22 12:58 PM
nameless chemicals is a cute band name
Awwwhhh 3
REAL 3
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ibtisam.midlet 29-Aug-22 04:41 AM
does anyone took Pseudoephedrine before
04:42
It cause physical comfort and feeling of excited
04:44
It seems to act selectivity on Hypothalamospinal tract which its desfunction linked to restless leg syndrom
04:45
https://en.m.wikipedia.org/wiki/Dopaminergic_pathways
Dopaminergic pathways
Dopaminergic pathways (dopamine pathways, dopaminergic projections) in the human brain are involved in both physiological and behavioral processes including movement, cognition, executive functions, reward, motivation, and neuroendocrine control. Each pathway is a set of projection neurons, consisting of individual dopaminergic neurons or dopami...
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Feeling is like when I wait a Instagram post to load, I just feel excited to see what is about This generally being in all life espect
04:51
The idea is Dosage on psdu 240mg/d
04:52
Because now when I took just 240mg it being powerful but next day that dose don't effect me
04:52
It need to be cycled every 4 days To work 240mgx 4 =960mg
04:52
If I took 960mg dose will it cause pesdu to work longterm??
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ibtisam.midlet
does anyone took Pseudoephedrine before
veganpermanently 29-Aug-22 05:15 AM
me
05:16
worst stim I ever took
05:17
produced stimulation for about 6 h
05:17
ruined my cardiovascular system permanently
05:17
had palpitations for months after
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Auwii 29-Aug-22 05:19 AM
cvd permanently
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ibtisam.midlet 29-Aug-22 05:20 AM
combining rehdiola aculvent dose of 240mg pesdu Then (240+240)x2=960mg
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veganpermanently 29-Aug-22 05:20 AM
U will die
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ibtisam.midlet 29-Aug-22 05:20 AM
I've always been good responser for everything
05:20
Dw
05:24
Intractable problems require intractable solutions 👍
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ΘωΘ 29-Aug-22 05:42 AM
hii
💟 2
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ibtisam.midlet
does anyone took Pseudoephedrine before
machineyadav 29-Aug-22 05:57 AM
I have taken phenylephrine
05:58
Sucks
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ibtisam.midlet 29-Aug-22 06:25 AM
@machineyadav descript good subjective effects
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ibtisam.midlet
@machineyadav descript good subjective effects
machineyadav 29-Aug-22 06:27 AM
Vasoconstriction and mao will be used breaking down phenylephrine so other drugs acts longer
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MEE6 BOT 29-Aug-22 06:27 AM
@machineyadav, you have advanced to lvl 3 respect++ emoji_51
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machineyadav 29-Aug-22 06:27 AM
However vasoconstriction is terrible
06:27
Even though bioavailability is 37% when taken oral
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ibtisam.midlet 29-Aug-22 06:27 AM
Does it produce any mood lift 995525573067677707
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ibtisam.midlet
Does it produce any mood lift 995525573067677707
machineyadav 29-Aug-22 06:28 AM
It surely did, not well compared to traditional stimulants, more like tachycardia causing caffeine dosage
06:29
5mg enhances dxm though
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ibtisam.midlet 29-Aug-22 06:29 AM
Yea most stimulant are mania inducers
06:29
I have problem finding that effect on any substance
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veganpermanently 29-Aug-22 06:51 AM
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machineyadav
It surely did, not well compared to traditional stimulants, more like tachycardia causing caffeine dosage
veganpermanently 29-Aug-22 06:52 AM
yea but caffeine is actually better
06:52
like less sides / same amount of stimulation
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Auwii 29-Aug-22 06:53 AM
I never want to feel like I have to take caffeine in the morning, or I will be feeling awful
06:53
I much prefer stims with no withdrawals
06:54
I want to be free of any dependency (edited)
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Auwii
I much prefer stims with no withdrawals
veganpermanently 29-Aug-22 06:57 AM
so basically modafinil
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Auwii 29-Aug-22 06:59 AM
Yeah, that seems to fit
06:59
But it is prescription, so not gonna get it
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Auwii
But it is prescription, so not gonna get it
veganpermanently 29-Aug-22 07:00 AM
I have a conspiracy theory about that
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Auwii 29-Aug-22 07:01 AM
What is it?
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Auwii
What is it?
veganpermanently 29-Aug-22 07:06 AM
Modafinil is heavily controlled in the US because it is a means of maintenance of the economical hierarchy. It removes the limitations of the lower class in terms of supressed drive and general outlook i.e. pessimism. The reason why methylphenidate and amphetamines are pushed instead is bcs they're unsustainable stimulants and don't promote cognition. Modafinil improves mitochondrial health over time and other stims destroy it. The lower class needs to do a money making marathon to move up the social ladder which is why these stims will never work for them - they provide a limited window of opportunity. The lower class needs to fight, get wrecked, get up and fight again. Repeat this a million times. There is no way to do this without Modafinil
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MEE6 BOT 29-Aug-22 07:06 AM
@veganpermanently, you have advanced to lvl 9 respect++ emoji_51
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Auwii 29-Aug-22 07:10 AM
Yes, this seems quite plausible, as amphetamines just make you do the dumb thing faster, not smarter. I can't imagine corporations or government wanting people to be more smart, beyond what is needed for people to do the work. Rich and powerful don't want to be overtaken by peasants. I would say you could substitute it with some kind of combination of supplements from nootropics depot, but that's way off from mainstream adoption and learning curve is high(also ain't cheap) (edited)
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MEE6 BOT 29-Aug-22 07:10 AM
@Auwii, you have advanced to lvl 1 respect++ emoji_51
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Auwii
Yes, this seems quite plausible, as amphetamines just make you do the dumb thing faster, not smarter. I can't imagine corporations or government wanting people to be more smart, beyond what is needed for people to do the work. Rich and powerful don't want to be overtaken by peasants. I would say you could substitute it with some kind of combination of supplements from nootropics depot, but that's way off from mainstream adoption and learning curve is high(also ain't cheap) (edited)
veganpermanently 29-Aug-22 07:23 AM
the truth is Modafinil will never have a replacement. It is an exogenous intraneuron antioxidant, it increases the expression of VMAT2, it stimulates vesicular trafficking via alpha1 adrenergic agonism. It is an orexin and histamine release agent. It blocks dopamine reuptake without letting anything out and displacing other stimulants i.e. drugs of abuse. This produces the following: Wakefulness promoting effect Improvement of memory Increase of locomotion Increase of subjective drive and motivation Antidepressant effect Decrease of addiction towards other stimulants - while other stims create cross tolerance and increase chance of addiction toward other stims Decrease of whole brain oxidative load esp. inside monoaminergic neurons - opposite of other stims Improvement of mitochondrial health - opposite of other stims Increase of appetite - opposite of other stims Vasodilation - opposite of other stims Increase of libido - opposite of other antidepressants all of this being sustainable and not very likely to produce tolerance quick makes it impossible to produce a substance or a combination thereof that produces the same effects It does have it's risks but the risks of poverty are much higher IMO
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Auwii 29-Aug-22 07:30 AM
It does certainly sound amazing, except for increase in apetite(lots of people are fat). Although quality of sources could be a concern, that's where much greater risks are(as is the case with many of street drugs) As for replacement, I am not that pessimistic, given so many various plants out there, with various yet undiscovered compounds in them, but it does seem like it doesn't exist yet. (edited)
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Auwii
But it is prescription, so not gonna get it
Yana 29-Aug-22 07:33 AM
There are dozens of gray market sites
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Auwii 29-Aug-22 07:34 AM
Yeah, I would guess, but main issue is trust
07:34
I am putting these things in my body
07:34
I want to be sure it is good
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Yana 29-Aug-22 07:35 AM
https://www.reddit.com/r/modareviewsnotbought/ banned 💀
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Auwii 29-Aug-22 07:35 AM
Rip
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Auwii
It does certainly sound amazing, except for increase in apetite(lots of people are fat). Although quality of sources could be a concern, that's where much greater risks are(as is the case with many of street drugs) As for replacement, I am not that pessimistic, given so many various plants out there, with various yet undiscovered compounds in them, but it does seem like it doesn't exist yet. (edited)
veganpermanently 29-Aug-22 07:43 AM
if you remove animal products from your diet as well as the unhealthy processed foods / there are lots of healthy proccessed foods / and increase locomotion, you don't have a problem with overeating anymore, you have a problem with undereating.
07:44
therefore at least for me having a good appetite is not only welcomed but a necessity
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Auwii 29-Aug-22 07:44 AM
Or I could just balance it out with saffron extract
07:44
Appetite is not that hard to control the way you want (edited)
07:46
That said, I don't know much about veganism (edited)
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Auwii
That said, I don't know much about veganism (edited)
veganpermanently 29-Aug-22 07:47 AM
it decreases caloric density of food immensely
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Auwii 29-Aug-22 07:48 AM
I see
07:48
Just this protein intake is likely hard to meet
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blank 29-Aug-22 09:04 AM
Unless you are literally a bodybuilder protein intake barely matters at all
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Auwii
Just this protein intake is likely hard to meet
veganpermanently 29-Aug-22 02:38 PM
what r u talkin about
14:38
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blank
Unless you are literally a bodybuilder protein intake barely matters at all
CEO 29-Aug-22 02:40 PM
Bodybuilding is a waste of time
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CEO
Bodybuilding is a waste of time
veganpermanently 29-Aug-22 02:48 PM
your frail self at 65 will regret this
14:49
hell you'll regret it at 50
14:49
at 65 you'll just crumble
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CEO 29-Aug-22 02:50 PM
Idk having huge muscles doesn’t seem beneficial to me
14:50
Prefer to be slimmer but fit
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veganpermanently
Click to see attachment 🖼️
Auwii 29-Aug-22 02:50 PM
When I was looking at it, I found it complicated I guess you got it figured out
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CEO
Idk having huge muscles doesn’t seem beneficial to me
veganpermanently 29-Aug-22 02:51 PM
having huge muscles is not something you just choose to have you know
14:51
it's an insane amount of hard work
14:52
so it won't happen by accident if you decide to train to avoid frailty at an older age
14:52
bodybuilding in terms of what it is today, yeah it's a shame
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Auwii 29-Aug-22 02:54 PM
Training lots and eating lots of protein is sure an absolute necessity at old age (edited)
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MEE6 BOT 29-Aug-22 02:54 PM
@Auwii, you have advanced to lvl 2 respect++ emoji_51
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Auwii 29-Aug-22 02:54 PM
But at young age say 25, I am not so sure
14:55
We do know methionine and mtor are linked with aging At old age you are of course trying to max those things out to still be able to function, bit at young age it may be beneficial to tone those things down (edited)
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veganpermanently
bodybuilding in terms of what it is today, yeah it's a shame
CEO 29-Aug-22 02:55 PM
That’s what I’m referring to
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MEE6 BOT 29-Aug-22 02:55 PM
@CEO, you have advanced to lvl 1 respect++ emoji_51
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Auwii
Training lots and eating lots of protein is sure an absolute necessity at old age (edited)
veganpermanently 29-Aug-22 03:00 PM
u will not make any gains at 65
15:00
at that point it's all about preservation
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Auwii
When I was looking at it, I found it complicated I guess you got it figured out
Yana 29-Aug-22 03:00 PM
It is complicated getting brotein if you want to avoid antinutrients, goitrogens, phytic acid, and high phosphorus content
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Yana
It is complicated getting brotein if you want to avoid antinutrients, goitrogens, phytic acid, and high phosphorus content
veganpermanently 29-Aug-22 03:00 PM
laughable weirds
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Yana 29-Aug-22 03:01 PM
Getting <60 or so is relatively easy
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veganpermanently
u will not make any gains at 65
Auwii 29-Aug-22 03:01 PM
I am more thinking age 40 or 50
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veganpermanently
if you remove animal products from your diet as well as the unhealthy processed foods / there are lots of healthy proccessed foods / and increase locomotion, you don't have a problem with overeating anymore, you have a problem with undereating.
Odder_Sea (Glowie) 29-Aug-22 03:01 PM
Ain't this the truth. My goal is to get more whole carbs and salt in my diet
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veganpermanently
Click to see attachment 🖼️
Odder_Sea (Glowie) 29-Aug-22 03:03 PM
Jeebus. I was at 150g the other day, and felt like I was getting too much
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Yana
It is complicated getting brotein if you want to avoid antinutrients, goitrogens, phytic acid, and high phosphorus content
Auwii 29-Aug-22 03:03 PM
Huh, really? Even if you blast pea protein?
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Auwii
Huh, really? Even if you blast pea protein?
Yana 29-Aug-22 03:04 PM
Nah but isn't that cheating
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Yana
Nah but isn't that cheating
Auwii 29-Aug-22 03:04 PM
True, it is
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Yana
Nah but isn't that cheating
veganpermanently 29-Aug-22 03:04 PM
look at mah day
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Yana 29-Aug-22 03:04 PM
I'm not against it though that's what I'll do for a while probably
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veganpermanently 29-Aug-22 03:04 PM
80 g of that amount is pea protein
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Yana 29-Aug-22 03:05 PM
Have you tried other kinds like rice protein?
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Yana
Have you tried other kinds like rice protein?
veganpermanently 29-Aug-22 03:05 PM
never will I ever
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Yana 29-Aug-22 03:05 PM
I saw this brand of brown rice protein on cronometer that had like 8x the methionine of pea lol
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veganpermanently 29-Aug-22 03:05 PM
P protein is king
15:05
cheaper than whey
15:05
same gains
15:05
half the methionine
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Yana 29-Aug-22 03:06 PM
What about digestibility
15:06
All the amino acid compositions of vegan proteins seem to be pretty good
15:06
Normal leucine if that's even something you want
15:06
etc
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Yana
What about digestibility
veganpermanently 29-Aug-22 03:06 PM
the factors you think matter don't
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Yana
Getting <60 or so is relatively easy
Auwii 29-Aug-22 03:06 PM
I wanted to say I am not getting even that But I just checked my 0.77$ pizzas I have in stock that I eat daily, and they do have 30 g protein each, I am surprised
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veganpermanently
the factors you think matter don't
Yana 29-Aug-22 03:06 PM
Wdym
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Yana
Wdym
veganpermanently 29-Aug-22 03:07 PM
simply look at intervention studies
15:07
it's the same
15:07
so even if digestibility is worse it doesn't matter
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Yana 29-Aug-22 03:07 PM
Wdym factors
15:07
What is the same
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veganpermanently 29-Aug-22 03:07 PM
the gainz
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Yana 29-Aug-22 03:08 PM
Yeah but what about toilet gains
15:08
And GI gains
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veganpermanently 29-Aug-22 03:08 PM
toilet is okay
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Yana 29-Aug-22 03:08 PM
But if pea is the most easily digestible for most ppl then well end of story
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Odder_Sea (Glowie) 29-Aug-22 03:09 PM
Most of those "antinutrients" are evidenced to be generally health promoting
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veganpermanently 29-Aug-22 03:09 PM
yeah I giggle every time someone mentions phytic acid and goitrogens
15:10
like dude
15:10
luteolin glycosides are an issue?
15:10
ROFLMAO
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veganpermanently
yeah I giggle every time someone mentions phytic acid and goitrogens
Yana 29-Aug-22 03:13 PM
I'm not good at converting in vitro mMol into human equivalent doses. What are antinutrients you actually avoid
15:14
Are you saying negatives are overplayed
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Yana
Are you saying negatives are overplayed
veganpermanently 29-Aug-22 03:14 PM
there are no negatives
15:14
it's a fucking farce
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Yana 29-Aug-22 03:15 PM
Goitrogens?
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MEE6 BOT 29-Aug-22 03:15 PM
@Yana, you have advanced to lvl 6 respect++ emoji_51
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Yana
Goitrogens?
veganpermanently 29-Aug-22 03:15 PM
indeed
15:15
but you know what isn't a farce
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Yana 29-Aug-22 03:15 PM
Now I'm enlightened
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veganpermanently 29-Aug-22 03:15 PM
estrogenic activity of Lamiaceae herbs
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15:16
tho the culinary amounts may not cause this
15:16
but used as supplement def
15:17
anyways I'm trying to biohack acne and sebum secretion
15:18
found a few cheap solutions
15:18
will try tomorrow
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Odder_Sea (Glowie) 29-Aug-22 03:44 PM
I wouldn't say that there no downsides, just that they downsides that do exist are easily prevented mitigated. Also, guess what the anti-plant crusader conveniently leave out? (Animal flesh contains lectins too... nasty ones.)
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ibtisam.midlet 30-Aug-22 02:09 AM
https://youtu.be/of2O04tLJN8
waveya 2011
Waveya_ 제시 쎈언니 Jessi SSENUNNI cover dance
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Netizenne 30-Aug-22 02:58 AM
Image attachment
02:58
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ibtisam.midlet 30-Aug-22 06:10 AM
Sam-e is reallly underrated noot
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Netizenne
Click to see attachment 🖼️
ibtisam.midlet 30-Aug-22 07:31 AM
+_+
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Auwii 30-Aug-22 07:35 AM
o.o
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Free Will I Am 30-Aug-22 07:35 AM
OwO
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machineyadav 30-Aug-22 10:16 AM
Oo
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CEO
Idk having huge muscles doesn’t seem beneficial to me
Potential 30-Aug-22 11:34 AM
It is beneficial because it impacts your success in life.
11:36
Just like height does.
11:37
I've already conquered one of these. Next, I am going to break my own legs so that I can gain 20cm. 975869370045722694
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ibtisam.midlet 30-Aug-22 12:20 PM
@Netizenne did you found any potent substance target oxytocin
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ibtisam.midlet
@Netizenne did you found any potent substance target oxytocin
veganpermanently 30-Aug-22 02:30 PM
oxytocin is targeted by more things than ppl think
14:30
all catecholaminergics cause oxytocin release. vitamin C as well and the effects are additive
14:30
recently I discovered ascorbyl palmitate has better availability to the brain
14:31
some substances inhibit oxy breakdown we should find a low hanging fruit among those
14:31
I ordered EDTA but I'm hesistant to try it
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veganpermanently
recently I discovered ascorbyl palmitate has better availability to the brain
Odder_Sea (Glowie) 30-Aug-22 02:33 PM
That's what I've been using. Acute administration doesn't raise serum valuse as high as ascorbic acid, but continued usage increases intracellular ascorbate moreso than ascorbic acid, like due to its lipophilic nature
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Odder_Sea (Glowie)
That's what I've been using. Acute administration doesn't raise serum valuse as high as ascorbic acid, but continued usage increases intracellular ascorbate moreso than ascorbic acid, like due to its lipophilic nature
veganpermanently 30-Aug-22 02:35 PM
I keep wondering if it would induce oxaluria at all
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veganpermanently
I keep wondering if it would induce oxaluria at all
Odder_Sea (Glowie) 30-Aug-22 02:37 PM
I was hoping it wouldn't impact oxalates in the manner as ascorbic acid
14:38
It's dosage is generally a lot lower as well compared to water soluble forms, so that should cut down by 80% off the top, ignoring other dynamics
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veganpermanently
some substances inhibit oxy breakdown we should find a low hanging fruit among those
Netizenne 30-Aug-22 02:44 PM
Removing IRAP, the enzyme that metabolizes oxytocin into MIF1, seems to block its antidepressant effects https://pubmed.ncbi.nlm.nih.gov/23177092/ (edited)
Antidepressant-like effects of oxytocin in mice are dependent on th...
Oxytocin is a neuromodulator with antidepressant-like effects. In vitro, oxytocin is rapidly cleaved by insulin-regulated aminopeptidase (IRAP). Oxytocin metabolites are known to exert strong central activities that are different from the effects of the parent molecule. Our goal is to investigate in …
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14:44
Circle arrow is PAM
14:46
Insulin-regulated aminopeptidase (IRAP)
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ibtisam.midlet
@Netizenne did you found any potent substance target oxytocin
Netizenne 30-Aug-22 02:49 PM
Not really tbh Semax mimics some effects of MIF1 on melanocortin receptors. That’s about all. Magtein sensitizes oxytocin receptors.
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Netizenne
Removing IRAP, the enzyme that metabolizes oxytocin into MIF1, seems to block its antidepressant effects https://pubmed.ncbi.nlm.nih.gov/23177092/ (edited)
veganpermanently 30-Aug-22 02:58 PM
great find
14:58
u golden again Neti
Awwwhhh 1
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veganpermanently 30-Aug-22 03:17 PM
well that's out the way
15:19
maybe we should increase both synthesis and metabolism
15:20
easier said than done tho
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ibtisam.midlet 30-Aug-22 07:57 PM
From my exp Oxytocin vs serotonin orgasm: yes. Yes(strong)
19:58
social recognition: yes. Yes(weak)
19:58
pair bonding: yes. Yes(strong)
19:58
anxiety:(empathy/caring mediated: yes. Yes(strong)
19:59
in-group bias: yes. No(generating argument for both sides)
19:59
honesty: dishonesty in the participants' responses increased for their in-group members when a beneficial outcome for their group was expected (both oxy and sero)
19:59
Bonding: yes. Yes(strong)
20:00
Maternal behavior: yes. Yes(strong)
20:00
Fear learning(when someone mad at you): fear lack of anxiety response (you just say: nahhh relax!!) Adrenaline=fight response
20:01
addiction vulnerability: decrease, decrease , adrenaline=none clinically vaulable increase (The only part if addiction psychology that oxytocin increase is conditional place preference, you start falling in love with the place you was doing drugs in)
20:01
envy: yes, unk
20:01
Trust: yes. yes
20:01
Romantic attachment: yes. Yes(kissed my cousin )
💀 3
DiosaSkull 3
20:01
wound healing: yes (physically your body start care for his self) , unk
20:02
Cortisol: decrease(both oxy and sero relief stress more then produce it)
20:02
My exp was with serotonin not oxy Oxy data is from reading about it
20:04
What you think @Netizenne
20:04
This would be beneficial for you
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ibtisam.midlet
What you think @Netizenne
Netizenne 30-Aug-22 08:18 PM
How were you increasing serotonin for these anecdotes? (edited)
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Netizenne
How were you increasing serotonin for these anecdotes? (edited)
ibtisam.midlet 30-Aug-22 08:21 PM
Anafranil is strongest serotonin reuptake inhibitor
20:21
and lowest in tolerance
20:22
I'm on it from 2009 never stop working
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ibtisam.midlet
Fear learning(when someone mad at you): fear lack of anxiety response (you just say: nahhh relax!!) Adrenaline=fight response
Netizenne 30-Aug-22 08:22 PM
Could you clarify the oxytocin/serotonin difference for this one?
20:23
What are some best noots for both retroactively and proactively reducing fear learning..???
20:24
Wanna get d-serine soon which may help
20:25
I could use less adrenaline
20:25
I think
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ibtisam.midlet 30-Aug-22 08:36 PM
oxytocin make you express facial anxiety and increase fear response when threatened, and cause anxiety-mediated submissiveness, between serotonin truly do the opposite
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Netizenne
What are some best noots for both retroactively and proactively reducing fear learning..???
ibtisam.midlet 30-Aug-22 08:38 PM
serotonin, i don't know really why you ignore this
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ibtisam.midlet 30-Aug-22 08:53 PM
this adrenergic response 😎
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ibtisam.midlet
Romantic attachment: yes. Yes(kissed my cousin )
Free Will I Am 30-Aug-22 08:55 PM
Hot emoji_4
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ibtisam.midlet 30-Aug-22 08:55 PM
i should be called biology debugger
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Free Will I Am
Hot emoji_4
ibtisam.midlet 30-Aug-22 08:56 PM
haha i was not in connection with her before that, now she are my close friend irl (edited)
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Netizenne
I could use less adrenaline
veganpermanently 31-Aug-22 12:20 AM
Nah
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veganpermanently 31-Aug-22 12:29 AM
Increasing dopamine metabolism to NE is probably the best thing one can do. It reduces oxidative stress and neuromelanin formation within the DA neurons by shunting metabolism away from the countless dirty metabolites, it increases wakefulness when a person is exposed to light, but it induces sleep when in dark due to the AANAT stimulation in the pineal gland. This improves the circadian rhythm and generates N Acetyl Serotonin, Melatonin and it's metabolites. This further decreases oxidative load and increases plasticity via activation of TrkB. Defective dopamine metabolism has been demonstrated to be implicated in dementias.
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ibtisam.midlet 31-Aug-22 01:53 AM
What ya think about cabergoline as cognitive and mania inducer Its d2/3 selective agonist
01:55
My concern is with HT2b agonism
01:58
It cause heart valvulopathy
01:58
This study say it not really a problem https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240058/
Long-term cardiac (valvulopathy) safety of cabergoline in prolactinoma
Clinical relevance of association of cabergoline use for hyperprolactinemia and cardiac valvulopathy remains unclear.The aim of the study was to determine the prevalence of valvular heart abnormalities in patients taking cabergoline for the treatment ...
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01:59
Dopamine agonists/antagonists tend to work forever even if its depandance is rough
01:59
I'm thinking about microdosage of them (for some reasons)
02:02
Microdosing will give the major part of highest therapy dose , so I don't have interest in going more
02:07
It make you have the same logic and behaviors like elon musk, in microdosing it will upper standars and impulsivity in mild degree converting everyone from farmers to scientists (edited)
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ibtisam.midlet
It make you have the same logic and behaviors like elon musk, in microdosing it will upper standars and impulsivity in mild degree converting everyone from farmers to scientists (edited)
veganpermanently 31-Aug-22 02:17 AM
elon musk is a weak motherfucker
02:17
remove his wealth he is zero and will never regain the wealth
🤣 1
02:18
he is emotionally dependent and requires validation from others
02:19
he pretends to be aspergers autist genius but in fact he is a narcissist machiavelian prick
975906197771272273 1
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ibtisam.midlet 31-Aug-22 02:19 AM
In current life situation it will not give any benefits to have more then 30k dollar/month
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ibtisam.midlet
In current life situation it will not give any benefits to have more then 30k dollar/month
Maestus 31-Aug-22 02:23 AM
If you are working on a project or running a business then you’re excluded, the boundary of happiness becomes the object of your focus. Thereby you are also bounded to those in your comparative circles for emotional regulation. If you reorder your identity yes you are exactly correct, less becomes infinitely more.
💟 1
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veganpermanently
elon musk is a weak motherfucker
Maestus 31-Aug-22 02:24 AM
I try to judge little my friend, for I always project when I cast my shadows on another.
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Maestus
I try to judge little my friend, for I always project when I cast my shadows on another.
veganpermanently 31-Aug-22 02:24 AM
it's not a judgement it's an observation
02:25
I've been observing what that guy does for a long time it's very consistent
02:25
and he admits it himself
02:25
there's a video that explains it well
02:26
https://www.youtube.com/watch?v=UCS0SuPsDH4
Common Sense Skeptic
Elon Musk Claims of Asperger's
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Maestus 31-Aug-22 02:26 AM
Not vindicating him at all, just validating what is human to all of us.
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Maestus
Not vindicating him at all, just validating what is human to all of us.
veganpermanently 31-Aug-22 02:27 AM
it's a stereotype not a rule
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Maestus 31-Aug-22 02:28 AM
Can not Stereotypes be archetypal, no?
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veganpermanently 31-Aug-22 02:28 AM
most humans do this doesn't mean all humans do this
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Maestus
Can not Stereotypes be archetypal, no?
veganpermanently 31-Aug-22 02:29 AM
I ran across people that have the same argument as you many times
02:31
it is ironic because the act of accusation of judgemental projection is a judgemental projection itself unless the claimed statement is actually a judgemental projection which means it must not be a default position and if it is it makes the person fallacious and an enemy of truth
02:33
to be more exact an enemy of reality bcs if it is the default position there is nothing that is real. everything is subjective to the point another cannot even observe the actions of another human
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Maestus 31-Aug-22 02:34 AM
Well then we get into the meta analysis of perception and logic, for that I’d point you to Wittgenstein.
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Maestus
Well then we get into the meta analysis of perception and logic, for that I’d point you to Wittgenstein.
veganpermanently 31-Aug-22 02:35 AM
that's not fair is it
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veganpermanently
that's not fair is it
Maestus 31-Aug-22 02:37 AM
Well that’s definitely a valid judgement.
02:37
But few things are from man’s perspective.
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veganpermanently 31-Aug-22 02:39 AM
to be sincere I read only a bit of Wittgenstein, but everything I did read made me cringe. I see where society went wrong when I read that shit
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JUNGLE | Toasty 31-Aug-22 03:03 AM
wrong chat lmao
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ibtisam.midlet
oxytocin make you express facial anxiety and increase fear response when threatened, and cause anxiety-mediated submissiveness, between serotonin truly do the opposite
Netizenne 31-Aug-22 03:10 AM
I just ordered some demoxytocin so we’ll see!!!!! The way you describe Oxytocin makes it sound like it could engage 5HT1a biased serotonergic activity -due to the submissive quality of it reminding me of “passive coping”. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ (edited)
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Serotonin and brain function: a tale of two receptors
Previous attempts to identify a unified theory of brain serotonin function have largely failed to achieve consensus. In this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the ...
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Netizenne
I just ordered some demoxytocin so we’ll see!!!!! The way you describe Oxytocin makes it sound like it could engage 5HT1a biased serotonergic activity -due to the submissive quality of it reminding me of “passive coping”. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ (edited)
veganpermanently 31-Aug-22 03:24 AM
https://pubmed.ncbi.nlm.nih.gov/8334526/ Both receptors stimulate oxytocin release, but 5ht2a blocks it completely while 5ht1a only attenuate it.
Stimulation of 5-HT1A and 5-HT2/5-HT1C receptors induce oxytocin re...
Plasma oxytocin responses to the 5-HT1A receptor agonists 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), buspirone and ipsapirone, and the 5-HT2/5-HT1C receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)2-aminopropane (DOI) have been studied in conscious, freely moving male rats. All four compound …
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03:26
which means 5HT1A signalling potentiates 5HT2A activation-induced oxytocin release, while 5HT2A is the main MoA of serotonin-induced oxytocin release
03:27
https://pubmed.ncbi.nlm.nih.gov/1436376/
Activation of central D-1 dopamine receptors stimulates oxytocin re...
The stimulatory effect of dopamine (DA) on the release of oxytocin (OT) in lactating rats is exerted at the D-1 DA receptor subtype. Because the neural loci mediating this effect have not been identified, the objective of the present studies was to test whether OT release in the lactating rat would …
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03:28
https://www.sciencedirect.com/science/article/pii/S0018506X20301033
The role of D2 dopamine receptors in oxytocin induced place prefere...
Neuropeptide oxytocin (OT) is involved in the regulation of social and non-social behaviour. The central nucleus of amygdala (CeA), part of the limbic…
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03:29
D1 receptor signalling also stimulates OT release, while D2 receptor appears to mediate it's behavioral effects since antagonists cancel it
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Netizenne
I just ordered some demoxytocin so we’ll see!!!!! The way you describe Oxytocin makes it sound like it could engage 5HT1a biased serotonergic activity -due to the submissive quality of it reminding me of “passive coping”. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606297/ (edited)
Maestus 31-Aug-22 03:42 AM
https://www.hedweb.com/ecstasy/index.html
03:43
I hope to see something like this in my lifetime.
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MEE6 BOT 31-Aug-22 03:43 AM
@Maestus, you have advanced to lvl 2 respect++ emoji_51
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Maestus
https://www.hedweb.com/ecstasy/index.html
veganpermanently 31-Aug-22 07:08 AM
that was a great read. sadly it doesn't mention it's effect on VMAT2 which is by far most important both in terms of it's behavioral effects and catecholaminergic depletion following use
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ibtisam.midlet
What ya think about cabergoline as cognitive and mania inducer Its d2/3 selective agonist
Yana 31-Aug-22 09:13 AM
This can be done
09:14
https://www.pinknews.co.uk/2011/02/01/man-says-parkinsons-drug-turned-him-into-gay-sex-addict/
Benjamin Cohen
Man says Parkinson’s drug turned him into gay sex addict
A French man is suing pharmaceuticals giant Glaxo because he claims that a drug used to treat his Parkinson's disease turned him into a gay sex addict.
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09:15
https://amp.theguardian.com/uk/2001/jul/12/medicalscience.highereducation
Drug 'made me a deranged sex maniac' | UK news | The Guardian
A businessman turned into a "deranged sex maniac" under the influence of prescribed drugs, the high court heard yesterday.
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Yana
https://www.pinknews.co.uk/2011/02/01/man-says-parkinsons-drug-turned-him-into-gay-sex-addict/
ibtisam.midlet 31-Aug-22 09:59 AM
Its more severe then that, look https://www.vox.com/2014/10/20/6995011/addiction-dopamine-agonist-parkinsons
Warning: this Parkinson's drug can make you addicted to gambling, s...
Messing with the brain's dopamine supply might not be a great idea.
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Yana
https://www.pinknews.co.uk/2011/02/01/man-says-parkinsons-drug-turned-him-into-gay-sex-addict/
ibtisam.midlet 31-Aug-22 10:13 AM
Who I'm?
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nomegatto 31-Aug-22 10:33 AM
Hey guys i just joined to the server. Glad to see you are talking about dopamine, one of the reason why i'm here is that I want to learn how to maximize dopamine receptors sensitivity and keep them healthy
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ibtisam.midlet 31-Aug-22 10:41 AM
You are welcome
10:41
read intent, and traval channels/thread to see what we research about
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nomegatto
Hey guys i just joined to the server. Glad to see you are talking about dopamine, one of the reason why i'm here is that I want to learn how to maximize dopamine receptors sensitivity and keep them healthy
ibtisam.midlet 31-Aug-22 10:47 AM
D2 receptor can be severely upregulated by some retinoid RXR-gamma receptors agonists Due to normally %40 of D2 is transcripted by them
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nomegatto
Hey guys i just joined to the server. Glad to see you are talking about dopamine, one of the reason why i'm here is that I want to learn how to maximize dopamine receptors sensitivity and keep them healthy
ibtisam.midlet 31-Aug-22 10:52 AM
Or you can use retinoid (vit A) it self 25.000IU sperated to 4 times a day, tested and working
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ibtisam.midlet
Or you can use retinoid (vit A) it self 25.000IU sperated to 4 times a day, tested and working
nomegatto 31-Aug-22 10:53 AM
But what happen when you stop taking it? (edited)
10:54
There should be no crash right
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veganpermanently 31-Aug-22 10:54 AM
retinoid are not and cannot be made safe
10:54
anyways
10:55
explain the mystery of alpha methyl tyrosine
10:55
I feel that might hold some clues
10:55
pretreatment attenuates meth induced dopamine depletion which I found odd
10:56
TH deficiency must lead to some other mechanism being upregulated
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nomegatto
But what happen when you stop taking it? (edited)
ibtisam.midlet 31-Aug-22 11:00 AM
nope
11:04
Some study https://pubmed.ncbi.nlm.nih.gov/20620876
Retinoid x receptor gamma control of affective behaviors involves d...
Abnormal signaling by retinoids or n-3 polyunsaturated fatty acids has been implicated in clinical depression. The converging point in activities of these two classes of molecules is transcriptional activation of retinoid X receptors (Rxr). We show here that ablation of Rxrgamma in mice leads to dep …
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nomegatto 31-Aug-22 11:06 AM
I'll check it out, thanks
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ibtisam.midlet 01-Sep-22 12:16 AM
bell-shaped and U/J-shaped dose response curves https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939687/figure/f1-drp-08-253/?report=objectonly
Potential Relevance of Bell-Shaped and U-Shaped Dose-Responses for ...
Tumor angiogenesis, the growth of new blood vessels into tumors, facilitates tumor growth and thus represents an attractive therapeutic target. Numerous experimental angiogenesis inhibitors have been characterised and subsequently trialled in patients. ...
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ibtisam.midlet
Some study https://pubmed.ncbi.nlm.nih.gov/20620876
veganpermanently 01-Sep-22 02:25 AM
if u want selective ligand there is one. It doesn't look good tho'. https://www.frontiersin.org/articles/10.3389/fphar.2021.613211/full
Frontiers | Bexarotene Impairs Cognition and Produces Hypothyroidis...
All individuals with Down syndrome (DS) eventually develop Alzheimer’s disease (AD) neuropathology, including neurodegeneration, increases in β-amyloid (Aβ) expression, and aggregation and neurofibrillary tangles, between the third and fourth decade of their lives. There is currently no effective treatment to prevent AD neuropathology and the as...
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Free Will I Am 01-Sep-22 02:32 AM
https://neurosciencenews.com/brain-sync-distance-21330/
Neuroscience News
Interacting Brains Sync Without Physical Presence - Neuroscience News
The brains of people playing online video games synchronize, even when there is a physical distance between the players.
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02:32
I've never been able to do this and that's why my friend told me I was autistic
02:33
Somewhat similar to Elon, I just self diagnosed off of that but in truth idfk
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Free Will I Am
Somewhat similar to Elon, I just self diagnosed off of that but in truth idfk
veganpermanently 01-Sep-22 02:33 AM
did u watch the vid I posted
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MEE6 BOT 01-Sep-22 02:33 AM
@veganpermanently, you have advanced to lvl 10 respect++ emoji_51
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veganpermanently
if u want selective ligand there is one. It doesn't look good tho'. https://www.frontiersin.org/articles/10.3389/fphar.2021.613211/full
ibtisam.midlet 01-Sep-22 02:33 AM
They said it produce hyperactivity, so yes it upregulate D2
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veganpermanently
did u watch the vid I posted
Free Will I Am 01-Sep-22 02:33 AM
Half of it
02:34
Up to the point where he said to look at the traits of autsim and showed the list but I didn't watch the breakdown
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ibtisam.midlet
They said it produce hyperactivity, so yes it upregulate D2
veganpermanently 01-Sep-22 02:34 AM
depending on brain state it could either permanently improve cognition or cause neurodegeneration
02:35
it's a dice roll esp if you have APOE4 genes but it's more to this than just that, receptor dimer expression is modulated
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veganpermanently
depending on brain state it could either permanently improve cognition or cause neurodegeneration
ibtisam.midlet 01-Sep-22 02:36 AM
Yes I'm my self was searching for antagonist so I down regulate D2
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veganpermanently 01-Sep-22 02:38 AM
btw I cured my acne in 3 days
02:38
we'll see how much it lasts
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ibtisam.midlet 01-Sep-22 02:38 AM
My friend who are Wall of text specialist and complexity addict, took retinoid and now he are in psychosis and broke up with me due to him being start being soo sensitive to anxiety if I said something against his opinion
02:38
He can't work with any biohacker right now
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veganpermanently 01-Sep-22 02:39 AM
he transcended
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ibtisam.midlet 01-Sep-22 02:40 AM
Its tuning therpy good for Generality that what I can say
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Free Will I Am
I've never been able to do this and that's why my friend told me I was autistic
Free Will I Am 01-Sep-22 02:41 AM
On the plus side, I could just carry the match by 1v2ing everyone and winning to the amazement of people watching so
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ibtisam.midlet 01-Sep-22 02:41 AM
When you have superior Dopamine 1 then upregulate D2 like you want (edited)
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Free Will I Am
I've never been able to do this and that's why my friend told me I was autistic
ibtisam.midlet 01-Sep-22 02:45 AM
If you have symptoms then don't care about diagnosis
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veganpermanently 01-Sep-22 02:46 AM
then you grow a bunch of D1D2 heterodimers
02:46
@ibtisam.midlet https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948031/
Dopamine D1 Receptor Agonist and D2 Receptor Antagonist Effects of ...
(−)–Stepholidine (SPD), an active ingredient of the Chinese herb Stephania, is the first compound found to have dual function as a dopamine receptor D1 agonist and D2 antagonist. Insights into dynamical behaviors of D1 and D2 receptors ...
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02:47
u know about this one
02:47
I'm not sure if any humans tried it at all
02:47
https://www.nature.com/articles/cddis2015315
L-Stepholidine rescues memory deficit and synaptic plasticity in mo...
Cell Death & Disease - L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer’s disease via activating dopamine D1 receptor/PKA signaling pathway
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02:47
I wonder if it would cause extrapyramidal sides
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ibtisam.midlet 01-Sep-22 02:50 AM
D1 is protective against schizophrenia and Parkinson
02:51
As long as you have enough D1 resource for PFC to calculate what D2 demand, you are safe
02:54
Otherwise you start getting memory considaltion errors (false memory..) And encoding-like errors
03:00
Thats in term of cognition
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veganpermanently 01-Sep-22 03:00 AM
Image attachment
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ibtisam.midlet 01-Sep-22 03:00 AM
but In term of productivity
03:00
If you get a farmer and upregulated his D1 he will be productive and just farms all the country with potato's (Africa )
03:01
Co-agonist his D2 and his standards get better (western)
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ibtisam.midlet
As long as you have enough D1 resource for PFC to calculate what D2 demand, you are safe
ibtisam.midlet 01-Sep-22 03:03 AM
@Sirsadalot you seems to have the same opinion
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ibtisam.midlet 01-Sep-22 10:04 AM
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ibtisam.midlet
Click to see attachment 🖼️
CEO 01-Sep-22 10:04 AM
They need more ass
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Free Will I Am 01-Sep-22 10:56 AM
Ong
10:57
If only more Asian women were like nnnnekochan (moved to #meme-anime-n-decent-silly-😆 ) (edited)
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ibtisam.midlet 01-Sep-22 10:59 AM
Wait wait this should be spoiled emoji_50
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Free Will I Am 01-Sep-22 10:59 AM
Kek
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MEE6 BOT 01-Sep-22 10:59 AM
@Free Will I Am, you have advanced to lvl 2 respect++ emoji_51
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Free Will I Am 01-Sep-22 10:59 AM
How do you spoiler images?
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Original message was deleted or could not be loaded.
CEO 01-Sep-22 10:59 AM
emoji_14
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Free Will I Am 01-Sep-22 11:00 AM
Do you just type when attaching images
11:00
" | |. | | "
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CEO 01-Sep-22 11:00 AM
SPOILER
Image attachment
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Free Will I Am 01-Sep-22 11:01 AM
Spoiler fail
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ibtisam.midlet 01-Sep-22 11:01 AM
Explisit stuff can be on meme n' decent silly channel , its need 18+ confirmation notice now
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Free Will I Am 01-Sep-22 11:02 AM
😢
11:02
Oki
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ibtisam.midlet
Explisit stuff can be on meme n' decent silly channel , its need 18+ confirmation notice now
CEO 01-Sep-22 11:02 AM
Rep white
11:02
SPOILER
Image attachment
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CEO
Click to see attachment 🖼️
Free Will I Am 01-Sep-22 11:03 AM
🤮 🤮 🤮
11:04
I love me some spics but not bbws
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Free Will I Am
🤮 🤮 🤮
CEO 01-Sep-22 11:04 AM
Rep white
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ibtisam.midlet 01-Sep-22 11:04 AM
SPOILER
11:04
He are doing it by will
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Free Will I Am 01-Sep-22 11:04 AM
How do you spoiler images and vids? (edited)
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CEO 01-Sep-22 11:04 AM
@Free Will I Am how’s your Pure O
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ibtisam.midlet 01-Sep-22 11:05 AM
And now please stop @CEO
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CEO
@Free Will I Am how’s your Pure O
Free Will I Am 01-Sep-22 11:05 AM
Not bad rn
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CEO 01-Sep-22 11:05 AM
When it’s like this click on the image again and the spoiler option will pop up
Image attachment
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Free Will I Am 01-Sep-22 11:05 AM
I have on and off moments when it comes to Pure O; I'm not really sure what triggers it (edited)
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Free Will I Am
I have on and off moments when it comes to Pure O; I'm not really sure what triggers it (edited)
CEO 01-Sep-22 11:06 AM
It hit me pretty hard last week
11:06
I was getting tormented
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Free Will I Am 01-Sep-22 11:06 AM
Yeah
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CEO 01-Sep-22 11:06 AM
Feeling better now but it’s changed the way I think about certain things
11:06
Can’t think normally anymore
11:06
It changes themes
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Free Will I Am 01-Sep-22 11:07 AM
Has it not always been a thing for you? I've had it for as long as I can remember
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ibtisam.midlet
Click to see attachment 🖼️
machineyadav 01-Sep-22 11:08 AM
Wtf
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Free Will I Am
Has it not always been a thing for you? I've had it for as long as I can remember
CEO 01-Sep-22 11:08 AM
I’ve had intrusive thoughts a lot but the Pure O started when I was 17
11:08
That’s when I remember it getting really bad
11:08
It’s changed themes
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machineyadav
Wtf
Free Will I Am 01-Sep-22 11:09 AM
Ikr?! Why are they shaking their asses when there's nothing to shake?!
😂 1
11:09
Criminal
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CEO
I’ve had intrusive thoughts a lot but the Pure O started when I was 17
Free Will I Am 01-Sep-22 11:09 AM
Always been there for me
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Free Will I Am
Always been there for me
CEO 01-Sep-22 11:11 AM
Does yours change themes as well
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CEO
Does yours change themes as well
Free Will I Am 01-Sep-22 11:12 AM
Not sure what you mean buddy
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ibtisam.midlet 01-Sep-22 11:15 AM
They surely need more boobs, but ass is just okay
11:15
Big ass rain beautifulness
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Free Will I Am 01-Sep-22 11:15 AM
Ass > Tits
11:15
Sorry not sorry
11:16
You can be flat as a board if your ass is nice plump and juicy
11:16
Ideally there's a bit of Booba there but I really don't care
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Free Will I Am
Ass > Tits
machineyadav 01-Sep-22 11:25 AM
Will have to disagree on that one 😄
11:25
@ibtisam.midlet post more boobs
11:25
Am in horny mood today
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Free Will I Am 01-Sep-22 11:25 AM
Everyone has their preference
👍 1
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CEO 01-Sep-22 11:25 AM
@ibtisam.midlet is Native American
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machineyadav 01-Sep-22 11:26 AM
Ibtisam posts amazing girls content ngl
11:26
Since I am not on nofap these days
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Free Will I Am 01-Sep-22 11:26 AM
But if we are going in to an evolutionary standpoint then big tits flop about everywhere and is impractical for running (hence sports bras etc) big titties don't necessarily count for more milk either
11:27
They are fun to play with though
😂 1
11:27
And super soft
11:27
My god
11:27
I love women
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machineyadav 01-Sep-22 11:27 AM
November is coming so these two months I will ruin my dopamine receptors
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Free Will I Am 01-Sep-22 11:28 AM
Kek
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machineyadav
November is coming so these two months I will ruin my dopamine receptors
machineyadav 01-Sep-22 11:28 AM
To the max
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Free Will I Am 01-Sep-22 11:28 AM
I fap 4 days a week
😮 1
11:28
I'm strict about it
11:28
Once on hump day and then over the weekends
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machineyadav 01-Sep-22 11:28 AM
I fap like degenerated when I start but go to nofap situation comes
11:29
There's no middle line for me
11:29
Either on upper or lower extreme
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Free Will I Am 01-Sep-22 11:29 AM
Been there bro
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machineyadav
Since I am not on nofap these days
Yana 01-Sep-22 11:30 AM
wtf happened to dopaminergic neuron feeding
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Yana
wtf happened to dopaminergic neuron feeding
machineyadav 01-Sep-22 11:30 AM
I ran out of money but will be back on feeding once swap bots goes online
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Yana 01-Sep-22 11:31 AM
is this really the best food
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Yana
is this really the best food
machineyadav 01-Sep-22 11:31 AM
Not the best but is what I can afford
11:31
The faucets I used to interact has it's api changed
11:32
Which would take more 28 hours to come back
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machineyadav
Not the best but is what I can afford
Free Will I Am 01-Sep-22 11:32 AM
Bro you need a sustainable income source before you splerg on nutrient dense foods
11:32
Or at least be growing it
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Free Will I Am
Bro you need a sustainable income source before you splerg on nutrient dense foods
machineyadav 01-Sep-22 11:33 AM
I had been spending around 10$ daily before all thing got messed up from yesterday
11:33
Money is still there but can't swap it to btc
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machineyadav
I had been spending around 10$ daily before all thing got messed up from yesterday
Free Will I Am 01-Sep-22 11:34 AM
Oh dear, some one ran it up too many times on the slot machine
😂 2
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Yana
wtf happened to dopaminergic neuron feeding
veganpermanently 01-Sep-22 12:39 PM
what the hell r u talking about
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Lux ✨ 01-Sep-22 01:46 PM
Don't let the brainworms consume you, masturbate freely
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~ Yuri le Flügel présomptueux ~ 01-Sep-22 01:50 PM
Hi, nootropics newbie here, looking for some info from the cognition savys. Feel free to join me in the vocal. 🙂
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JUNGLE | Toasty 01-Sep-22 01:53 PM
I fap every day
13:53
Before sleep, after taking melatonin, sleep like a baby
13:53
👍
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~ Yuri le Flügel présomptueux ~
Hi, nootropics newbie here, looking for some info from the cognition savys. Feel free to join me in the vocal. 🙂
ibtisam.midlet 01-Sep-22 01:55 PM
You should microdose substances targeting multiple pathways imooo
13:56
See here as example https://discord.com/channels/1001420842179239936/1014233351919521842/1014238519952166992
👍 1
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ibtisam.midlet
You should microdose substances targeting multiple pathways imooo
~ Yuri le Flügel présomptueux ~ 01-Sep-22 01:56 PM
Interesting, would you like to talk in depth about it in the vc?
13:58
Thank you🙂
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ibtisam.midlet 01-Sep-22 01:58 PM
Cell to mee personally
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~ Yuri le Flügel présomptueux ~ 01-Sep-22 01:58 PM
Ok 👌
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veganpermanently
what the hell r u talking about
Yana 01-Sep-22 02:21 PM
An old alias of his
14:21
He used to foster exotic cultivars of dopaminergic neurons via DXM
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ibtisam.midlet
Click to see attachment 🖼️
Netizenne 01-Sep-22 02:40 PM
They are advertising their fertility and good health So are they trying to get married then…?
14:41
It’s a mating dance I think
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veganpermanently 01-Sep-22 02:42 PM
they gettin railed
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Yana
He used to foster exotic cultivars of dopaminergic neurons via DXM
veganpermanently 01-Sep-22 02:43 PM
I'd smoke some of those
14:48
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.18-0162 @Yana @ibtisam.midlet @Netizenne time for some science fix-ion snorting vesicles snorting mitochondria next up we're snorting receptors Les go motherfuckers
😅 1
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Netizenne
They are advertising their fertility and good health So are they trying to get married then…?
ibtisam.midlet 01-Sep-22 03:07 PM
not really, i have the same wanting its because public sex is sooo pleasurable
15:13
seems estradiol have great role in why they express that with dancing
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ibtisam.midlet
See here as example https://discord.com/channels/1001420842179239936/1014233351919521842/1014238519952166992
blank 01-Sep-22 03:14 PM
Can you very carefully explain why this isn't a bad idea
🤭 1
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ibtisam.midlet 01-Sep-22 03:24 PM
Intractable problems require intractable solutions
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MEE6 BOT 01-Sep-22 03:24 PM
@ibtisam.midlet, you have advanced to lvl 16 respect++ emoji_51
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blank
Can you very carefully explain why this isn't a bad idea
ibtisam.midlet 01-Sep-22 03:27 PM
and i'm in month 7 from starting this project
15:28
i faced a lot of problems no one know about
15:28
and solved all of them right now
15:29
still just the probem that combining 12 substance is not trialed by someone with no pre-intake of the substances (no tolerance)
15:30
in first all substances doses combined need to be equal to one normal substance dose
15:31
then double the dose every month, with no caring about tolerance developed or not
15:32
until you reach x8 to x(number of substance x 8) of what you started with
emoji_51 2
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ibtisam.midlet 01-Sep-22 03:40 PM
all of this substances is mixed in one powder emoji_49
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ibtisam.midlet 01-Sep-22 03:52 PM
Then you will have this life
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Free Will I Am 01-Sep-22 09:30 PM
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Maestus 01-Sep-22 10:31 PM
I don’t want to deal with all this virgin crap
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Maestus
I don’t want to deal with all this virgin crap
veganpermanently 02-Sep-22 12:17 AM
much judgement projection eh?
00:18
emoji_17
00:18
u know what this emoji is
00:18
vegan blood sample
00:20
Image attachment
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ibtisam.midlet 02-Sep-22 01:53 AM
From now porn is limited to decent silly channel You can post in causal, cute anime and pretty girls with sexy cloths but not more then that. it should be intented to aesthetic not sexual purpose
01:56
and don't rain a discussion with spamming that
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ibtisam.midlet
From now porn is limited to decent silly channel You can post in causal, cute anime and pretty girls with sexy cloths but not more then that. it should be intented to aesthetic not sexual purpose
veganpermanently 02-Sep-22 06:02 AM
kek ur the one that started doing this 😛
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ibtisam.midlet 02-Sep-22 06:08 AM
noticed irritability from a member
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veganpermanently 02-Sep-22 06:10 AM
https://www.youtube.com/watch?v=OZFt53axwqE
Danzim
Reject Modernity, Embrace Masculinity
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ibtisam.midlet
noticed irritability from a member
Free Will I Am 02-Sep-22 07:08 AM
He already left
07:08
It's fiiiiiine
07:08
We chillin
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Blossoming Tree of Peace 02-Sep-22 09:39 AM
WILLIAM
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Blossoming Tree of Peace
WILLIAM
Free Will I Am 02-Sep-22 09:43 AM
I am on top of the world rn! What's good Tree?!
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Blossoming Tree of Peace 02-Sep-22 09:43 AM
Everything except my monetary situation lmfao
09:43
Elsewise I'm greeaaat!
09:47
I lost one of my nicotine vapes
09:47
Good thing I plan with redundancy and have 2 kek
09:51
I think we have ourselves a dihexa day William
09:51
I see no flaws w this approach bc I don't work today
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Blossoming Tree of Peace
I think we have ourselves a dihexa day William
Free Will I Am 02-Sep-22 09:52 AM
Go for it champ 👍
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Blossoming Tree of Peace 02-Sep-22 09:53 AM
My autism superpowers will blow yout out of the pond
09:53
My memory at work was way better yesterday
09:54
However if I overdo it the opposite will occur
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Blossoming Tree of Peace
My autism superpowers will blow yout out of the pond
Free Will I Am 02-Sep-22 09:54 AM
My autism is on 24/7. It will be exciting to see someone reach my level
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Blossoming Tree of Peace 02-Sep-22 09:55 AM
I'm that unique type of exuberant autism
09:55
Where everyone says shutup while laughing at your jokes
☝️ 1
09:55
And I never shutup
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Blossoming Tree of Peace
Where everyone says shutup while laughing at your jokes
Free Will I Am 02-Sep-22 09:56 AM
That's me
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Blossoming Tree of Peace 02-Sep-22 09:56 AM
You have my autisms?
09:56
Wow omfg
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Blossoming Tree of Peace
You have my autisms?
Free Will I Am 02-Sep-22 09:56 AM
🥺 👉 👈
09:56
Besties?
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Blossoming Tree of Peace 02-Sep-22 09:57 AM
For leaf!
09:57
I mean life
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Free Will I Am 02-Sep-22 09:57 AM
💋 💋 💋
09:57
💁
09:57
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Blossoming Tree of Peace 02-Sep-22 09:57 AM
"Jordan why did you decide to be such a smartass"
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Blossoming Tree of Peace
"Jordan why did you decide to be such a smartass"
Free Will I Am 02-Sep-22 09:57 AM
LITERALLY ME
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Blossoming Tree of Peace 02-Sep-22 09:58 AM
Bc a dumbass is a dumbass obvi
☝️ 1
09:58
I might just go gay for you william
😳 1
09:58
Just for you
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Free Will I Am 02-Sep-22 09:58 AM
M....
09:59
M....
09:59
Me too!
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Blossoming Tree of Peace 02-Sep-22 09:59 AM
Faggot
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Free Will I Am 02-Sep-22 09:59 AM
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Blossoming Tree of Peace
Faggot
Free Will I Am 02-Sep-22 09:59 AM
Bender!
09:59
Bum boy!
09:59
gay slurs
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Blossoming Tree of Peace 02-Sep-22 09:59 AM
Bender gerder
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Free Will I Am 02-Sep-22 10:00 AM
Dude I would totally get gender reassignment if it was easy enough to switch back
10:00
I'd love to try being female for a few months just to see what it felt like
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Blossoming Tree of Peace 02-Sep-22 10:00 AM
I just put my shit in weird places now to test my cognition
10:00
Yea ikwym
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Blossoming Tree of Peace
I just put my shit in weird places now to test my cognition
Free Will I Am 02-Sep-22 10:00 AM
I know them ones
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Blossoming Tree of Peace 02-Sep-22 10:01 AM
My charger is on top of the dryer
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Free Will I Am 02-Sep-22 10:01 AM
Where's your wallet?
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Blossoming Tree of Peace 02-Sep-22 10:01 AM
And I have no clothes in thr dryerb
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MEE6 BOT 02-Sep-22 10:01 AM
@Blossoming Tree of Peace, you have advanced to lvl 4 respect++ emoji_51
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Free Will I Am 02-Sep-22 10:01 AM
Did you hide your keys?
10:01
That's a big one
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Blossoming Tree of Peace 02-Sep-22 10:01 AM
My wallet is in my pockets
10:02
As are keys
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Free Will I Am 02-Sep-22 10:02 AM
If you did that you got balls
10:02
Oh
10:02
Rip
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Blossoming Tree of Peace 02-Sep-22 10:02 AM
I normally do!
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Free Will I Am 02-Sep-22 10:02 AM
He's not ready for those levels
10:02
Tsk tsk
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Blossoming Tree of Peace 02-Sep-22 10:02 AM
Yes I am father
10:02
Father
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Free Will I Am 02-Sep-22 10:02 AM
It's okay leaf eventually you will have my ultra high cognition
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Blossoming Tree of Peace 02-Sep-22 10:02 AM
Father
10:02
Father
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Free Will I Am 02-Sep-22 10:02 AM
Just keep taking those noots
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Blossoming Tree of Peace 02-Sep-22 10:03 AM
I barely made it through elementary
10:03
There's a lot of upping to do
10:04
When every system becomes maxxed, my potential is realized
10:04
And that is when shit gets fun
10:05
Is moving your fingers around a stim?@Free Will I Am
10:05
For the autism I mean
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Blossoming Tree of Peace
Is moving your fingers around a stim?@Free Will I Am
Free Will I Am 02-Sep-22 10:09 AM
No stims unless your odd coffee brew counts
10:09
I'm clean as a whistle
10:10
I would be too op with noots so for the sake of giving everyone a fighting chance I decided to remain in base form
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Free Will I Am
I would be too op with noots so for the sake of giving everyone a fighting chance I decided to remain in base form
Blossoming Tree of Peace 02-Sep-22 11:02 AM
Excuses
11:02
Now I get to steal your thunder
11:02
Amd your lightning too!
11:03
Mwahahaha
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Blossoming Tree of Peace
Amd your lightning too!
Free Will I Am 02-Sep-22 12:57 PM
Come take it if you can
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Blossoming Tree of Peace 02-Sep-22 01:01 PM
Pussy
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Shawn シ 02-Sep-22 04:00 PM
can anybody help me with bio
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Shawn シ
can anybody help me with bio
ibtisam.midlet 02-Sep-22 05:28 PM
I'm here for you 😊
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Free Will I Am 03-Sep-22 12:49 AM
If Joshu enters then he's gonna win
Image attachment
00:49
He's the best typist in the world rn
00:49
He normally enters when money is on the line
00:51
He's done 300wpm raw on monkeytype with about 80 accuracy (which is normally bad but bro 300wpm raw)
00:51
I think his top is like 250 or something
00:52
https://www.youtube.com/watch?v=VzyGSzJK9Nc
joshu
252 WPM: Monkeytype 60s [Former WR]
00:53
https://www.youtube.com/watch?v=i79l8ZFNUmc
joshu
Monkeytype 300 WPM Raw time 15
00:53
Bottom corner shows raw
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Free Will I Am
He's done 300wpm raw on monkeytype with about 80 accuracy (which is normally bad but bro 300wpm raw)
ibtisam.midlet 03-Sep-22 03:26 AM
How his life, work, relationships, archivment in other fields
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ibtisam.midlet
How his life, work, relationships, archivment in other fields
Free Will I Am 03-Sep-22 03:51 AM
No clue 🤷‍♂️
03:52
He would make a fair few bucks from transcribing if he wanted to
03:52
I wouldn't be at all surprised if that's what he did for a living or at least as a side hustle
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ibtisam.midlet 03-Sep-22 08:45 AM
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ibtisam.midlet
Click to see attachment 🖼️
machineyadav 03-Sep-22 12:00 PM
Don't usually like girls with excessive piercings and goth girls but this one is beautiful 😍 (edited)
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machineyadav 03-Sep-22 12:12 PM
@ibtisam.midlet histamine can be strong though, a dual H1 agonist and H3 antagonist would be good drug to improve wakefulness, cogniton and attention (edited)
12:12
Or separate drug for H1 agonism and H3 antagonism combined
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machineyadav
Or separate drug for H1 agonism and H3 antagonism combined
Yana 03-Sep-22 12:27 PM
https://mybiohack.com/blog/conessine-sources-histamine-nootropic-stimulant
The 6+ Benefits Of Conessine (With Natural Sources And Mechanisms) ...
In this post, we will discuss the benefits and natural sources for the steroid alkaloid, Conessine.
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Yana
https://mybiohack.com/blog/conessine-sources-histamine-nootropic-stimulant
machineyadav 03-Sep-22 12:30 PM
emoji_51 emoji_50
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ibtisam.midlet 03-Sep-22 03:17 PM
Tested betahistine Its histamine 1 agonist And H3 antagonist (yea it also block negative feedback of histamine) That cross blood brain Barrie https://en.m.wikipedia.org/wiki/Betahistine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388750/
Betahistine
Betahistine, sold under the brand name Serc among others, is an anti-vertigo medication. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms. It was first registered in Europe in 1970 for the treatment of Ménière's disease but current evidence does not support its efficacy in treating it.
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Betahistine for symptoms of vertigo
Vertigo is a symptom in which individuals experience a false sensation of movement. This type of dizziness is thought to originate in the inner ear labyrinth or its neural connections. It is a commonly experienced symptom and can cause significant problems ...
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15:18
overdosing by 410mg, when max dose par day is 48mg, did not give me any psychoactive effect Just start hearing blood in my ears
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Yana
https://mybiohack.com/blog/conessine-sources-histamine-nootropic-stimulant
veganpermanently 03-Sep-22 03:20 PM
does anybdy have source for pure conessine
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ibtisam.midlet 03-Sep-22 03:22 PM
What ya think, Is intranasal administration possible for pro inflammatory substance like this?
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ibtisam.midlet
Click to see attachment 🖼️
Shawn シ 03-Sep-22 03:35 PM
you got me
🤭 1
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Free Will I Am
If Joshu enters then he's gonna win
Free Will I Am 03-Sep-22 08:21 PM
Aaaaaand he won
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Free Will I Am 03-Sep-22 08:30 PM
Kiregaki and joshu are both 280. Insane...
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blank 03-Sep-22 08:49 PM
how tf is that even possible
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Free Will I Am 03-Sep-22 08:50 PM
Monsters
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le_drig 03-Sep-22 10:49 PM
@ibtisam.midlet can i replace rexulti with cabergoline i just need d2 agonism
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Netizenne 03-Sep-22 11:13 PM
Is increased ACTH release responsible for the aggression of vasopressin while increased aldosterone responsible for the memory and problem solving abilities? Are the two separable?
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Netizenne
Is increased ACTH release responsible for the aggression of vasopressin while increased aldosterone responsible for the memory and problem solving abilities? Are the two separable?
JC Denton 03-Sep-22 11:19 PM
Good question
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le_drig
@ibtisam.midlet can i replace rexulti with cabergoline i just need d2 agonism
ibtisam.midlet 04-Sep-22 12:47 AM
not always works, some people cabergoline works in them as anti-Parkinson without psychoactive effect
00:48
also it does agonist HT2B which limit its long-term use to microdosing
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Netizenne
Is increased ACTH release responsible for the aggression of vasopressin while increased aldosterone responsible for the memory and problem solving abilities? Are the two separable?
ibtisam.midlet 04-Sep-22 01:14 AM
aggression of vasopressin yes also ability to recognize recently investigated mice like gangs does when someone join the club (sure)
01:14
aldosterone responsible for the memory and problem solving abilities? Edit its cortisol, aldosterone considered second function in this and not well studied, compared to cortisol profound effect on this (edited)
01:15
Are the two separable? mm i don't know really, i more in the mirror of adrenaline/serotonin
01:15
what i can say that https://en.wikipedia.org/wiki/Vasopressin_receptor_1B will give you socializing ability that gangs have
Vasopressin receptor 1B
Vasopressin V1b receptor (V1BR) also known as vasopressin 3 receptor (VPR3) or antidiuretic hormone receptor 1B is a protein that in humans is encoded by the AVPR1B (arginine vasopressin receptor 1B) gene. V1BR acts as a receptor for vasopressin. AVPR1B belongs to the subfamily of G-protein coupled receptors. Its activity is mediated by G protei...
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Netizenne 04-Sep-22 01:44 AM
https://pubmed.ncbi.nlm.nih.gov/2149831/
Aldosterone receptors are involved in the mediation of the memory-e...
The blockade of the memory-enhancing effects of piracetam resulting from adrenalectomy can be abolished by substitution with either corticosterone or aldosterone. However, corticosterone substitution does not reinstate these effects if the aldosterone receptors are blocked by the aldosterone antagon …
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01:45
Intranasal vasopressin is apparently a super powerful memory enhancer
01:45
It’s just dangerous so not often used
01:47
It synergizes with CRH to stimulate ACTH release in moments of stress. Stress = problem Stress response = problem solving
01:50
Vasopressin seems to act on HPA axis and renin angiotensin aldosterone axis? Does one control aggression and the other control brain blood supply / problem solving? I’m not familiar with the latter yet (edited)
01:53
Probably controls getting blood to the brain or muscles in times of need or something (edited)
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ibtisam.midlet 04-Sep-22 01:58 AM
Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells, v1a deficit decrease blood pleasure (edited)
01:58
https://pubmed.ncbi.nlm.nih.gov/18448596/
Vasopressin regulates the renin-angiotensin-aldosterone system via ...
The neuropeptide hormone arginine-vasopressin (AVP) is well known to exert its antidiuretic effect via the vasopressin V2 receptor (V2R), whereas the role of the vasopressin V1a receptor (V1aR) in the kidney remains to be clarified. Previously, we reported decreased plasma volume and blood pressure …
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Netizenne 04-Sep-22 01:59 AM
Okay gotta sleep gnnnnn
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ibtisam.midlet
Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells, v1a deficit decrease blood pleasure (edited)
Netizenne 04-Sep-22 02:06 AM
Vasopressin is also capable of causing vasoconstriction and increasing blood pressure.
It’s probably kinda complicated with biphasic reactions, acute vs long term effects, etc etc (edited)
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ibtisam.midlet 04-Sep-22 02:07 AM
https://www.ahajournals.org/doi/10.1161/circheartfailure.109.916114
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Netizenne 04-Sep-22 02:08 AM
I have to sleep fr this time sweet sleppitieesss!!!!!!!!!!!!!!!!!!!
🥚 2
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Free Will I Am 04-Sep-22 04:43 AM
The reason quantum computers will never be able to get beyond 54 qubits is that conservation electance effects are expected in departing from a single quantum coaction state to an erodible multientangled quantum electance state, yielding discordant resonance with reduced electrofermionic action and increased emissions of etheopolerized hyperstatic further desuperoccupying the entangled state. Meanwhile, an operation using electrochromatic nano-LEDs to maintain simultaneity would also fail due to the etheopolerized hyperstasic destabilizing the electrofermionic resonance of the Caddell-Huges simplified progression to the point where it will be impossible to maintain proper Perrier-Hall femtostasis, needed by the quantum registers.
04:43
As a counterpoint, it’s argued that electrochromatic flux in nano-LED’s and other capacitance based hardware emits sterolites which would allow for the reduction in micro-influxitance to the rest of the quantum state. The theory is shaky enough, and further, has never been demonstrated in a lab setting.
04:43
This is why computationally superior quantum computing is simply impossible, giving almost no computational gain over classical computers in almost all conditions. Qubits without a quantum register cannot calculate an electrofermionic artificial neural network, making it impossible to filter out usable data from the quantum state with enough accuracy to apply the technology to any relevant application. It would not be able to register the subtleties and algorithms hidden within quantum boolean completions, therefore failing at everything that matters. Checkmate, atheists.
04:45
@ΘωΘ
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Free Will I Am
This is why computationally superior quantum computing is simply impossible, giving almost no computational gain over classical computers in almost all conditions. Qubits without a quantum register cannot calculate an electrofermionic artificial neural network, making it impossible to filter out usable data from the quantum state with enough accuracy to apply the technology to any relevant application. It would not be able to register the subtleties and algorithms hidden within quantum boolean completions, therefore failing at everything that matters. Checkmate, atheists.
ΘωΘ 04-Sep-22 06:17 AM
https://youtu.be/pb7OWlVYYRw
cheriebibo
Retroincabulator
💟 1
06:18
all gombutation is guantum, because everything is guantum
06:19
googel "monoidal string diagram" kmao
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ΘωΘ
https://youtu.be/pb7OWlVYYRw
Free Will I Am 04-Sep-22 06:41 AM
Fascinating! I shall have to invest stocks in all 4 of these companies! I can see it taking off any day now; basically free money!
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ΘωΘ
https://youtu.be/pb7OWlVYYRw
ibtisam.midlet 04-Sep-22 07:21 AM
Was good idea to tell to tag you 🥳
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Free Will I Am 04-Sep-22 07:22 AM
Yes! We're gonna make a whole lotta money today 🤑
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Netizenne
Vasopressin seems to act on HPA axis and renin angiotensin aldosterone axis? Does one control aggression and the other control brain blood supply / problem solving? I’m not familiar with the latter yet (edited)
ibtisam.midlet 04-Sep-22 07:44 AM
Readed all papers again, Found there critical mistakes (aldosterone is not listed on RFD wasn't able to recall any memory about it) There some papers say opposite of others, but just followed the majority in this IMO Vasopressin increase blood pressure is mediated by aldosterone (after you agonist AVPR1A) https://pubmed.ncbi.nlm.nih.gov/18448596/ https://www.sciencedirect.com/science/article/pii/S0085253815538593 https://en.wikipedia.org/wiki/Vasopressin_receptor aggression, memory potentiation, problem solving is mediated by cortisol (after you agonist AVPR1B) https://en.wikipedia.org/wiki/Vasopressin_receptor_1B https://en.wikipedia.org/wiki/Vasopressin_receptor https://en.wikipedia.org/wiki/Adrenocorticotropic_hormone the only direct effect from Vasopressin is antidiuretic (V2R) and empathy mediated socializing (also by AVPR1A)
Vasopressin regulates the renin-angiotensin-aldosterone system via ...
The neuropeptide hormone arginine-vasopressin (AVP) is well known to exert its antidiuretic effect via the vasopressin V2 receptor (V2R), whereas the role of the vasopressin V1a receptor (V1aR) in the kidney remains to be clarified. Previously, we reported decreased plasma volume and blood pressure …
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Vasopressin regulation of blood pressure and volume: findings from ...
[Arg8]-vasopressin (AVP) has several functions via its three distinct receptors, V1a, V1b, and V2. The V1a vasopressin receptor (V1aR) is expressed in…
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Vasopressin receptor
The actions of vasopressin are mediated by stimulation of tissue-specific G protein-coupled receptors (GPCRs) called vasopressin receptors that are classified into the V1 (V1A), V2, and V3 (V1B) receptor subtypes. These three subtypes differ in localization, function and signal transduction mechanisms.
Vasopressin receptor 1B
Vasopressin V1b receptor (V1BR) also known as vasopressin 3 receptor (VPR3) or antidiuretic hormone receptor 1B is a protein that in humans is encoded by the AVPR1B (arginine vasopressin receptor 1B) gene. V1BR acts as a receptor for vasopressin. AVPR1B belongs to the subfamily of G-protein coupled receptors. Its activity is mediated by G protei...
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Adrenocorticotropic hormone
Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland. It is also used as a medication and diagnostic agent. ACTH is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stres...
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Free Will I Am 04-Sep-22 07:45 AM
Readed
07:45
07:45
Kawaii desu ne
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ibtisam.midlet 04-Sep-22 08:48 AM
Does anyone remember this
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Free Will I Am 04-Sep-22 08:52 AM
Today is a great day for coder-typists!
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ibtisam.midlet 04-Sep-22 09:00 AM
"Writing garbage software that kind of works sometimes " that's me emoji_8
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ibtisam.midlet
"Writing garbage software that kind of works sometimes " that's me emoji_8
Free Will I Am 04-Sep-22 09:02 AM
Yea I peeped the GitHub on the low
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Free Will I Am
Yea I peeped the GitHub on the low
ibtisam.midlet 04-Sep-22 09:03 AM
You can't beat me in writing garbage software
09:03
I'm superior!
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Free Will I Am 04-Sep-22 09:03 AM
Challenge accepted!
09:04
I will dominate in every challange no matter what!
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ibtisam.midlet 04-Sep-22 09:04 AM
Sorry I'm a dope girl!
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Free Will I Am 04-Sep-22 09:04 AM
I will write the longest most inefficient stream of bloat out there mark my words!
😂 1
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ibtisam.midlet 04-Sep-22 09:05 AM
I'll write broke hello world
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Free Will I Am 04-Sep-22 09:07 AM
I'll write a barely usable hello world that only works on discontinued instruction set architecture used on CPUs from the 80s that is written in 100 lines!
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Free Will I Am
I'll write a barely usable hello world that only works on discontinued instruction set architecture used on CPUs from the 80s that is written in 100 lines!
ibtisam.midlet 04-Sep-22 09:11 AM
i thinked about ram consuming hello world which will make laptop crash, but nah
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ibtisam.midlet
i thinked about ram consuming hello world which will make laptop crash, but nah
Free Will I Am 04-Sep-22 09:12 AM
!!!
09:12
I've gotta go harder it seems
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ibtisam.midlet 04-Sep-22 09:12 AM
this competition will need long-term benzo abuse
xd 1
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Free Will I Am 04-Sep-22 09:13 AM
Good luck! I'll make sure to buy out the entire stock to produce a shortage and scalp it at prices you can't afford
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blank
how tf is that even possible
𝔘𝔵𝔨ü𝔩𝔩 04-Sep-22 12:35 PM
https://www.youtube.com/watch?v=KlJ8eTuFe9U
Даниил Сас
ghost in the shell fingers
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Netizenne
Intranasal vasopressin is apparently a super powerful memory enhancer
𝔘𝔵𝔨ü𝔩𝔩 04-Sep-22 12:36 PM
iirc individuals low in vasopressin are much more likely to cheat, has a role in pair bonding
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ibtisam.midlet 05-Sep-22 06:14 AM
I think human cloning is already exist
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ibtisam.midlet 05-Sep-22 06:23 AM
From some gray area company's
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veganpermanently 05-Sep-22 06:25 AM
shut up and take my money
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ibtisam.midlet 05-Sep-22 06:25 AM
the reability/success rate of dark net being so low to be considered something
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veganpermanently 05-Sep-22 06:26 AM
06:26
minime so cute yet so gangsta (edited)
06:26
06:28
https://www.youtube.com/watch?v=znO2iRtWnpo
Pa Salieu
Pa Salieu - Mista / Lennon Freestyle
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veganpermanently
shut up and take my money
ibtisam.midlet 05-Sep-22 06:30 AM
Find me that company then we can talk
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veganpermanently 05-Sep-22 06:30 AM
I still need a good surrogate
06:31
hard to do
06:31
all of the women nowadays lazy and wrecked
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ibtisam.midlet 05-Sep-22 06:39 AM
Its $90,000 to $130,000
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Free Will I Am 05-Sep-22 06:40 AM
Wow! Didn't realize it was so affordable
06:40
@ExileMage
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ibtisam.midlet
Its $90,000 to $130,000
veganpermanently 05-Sep-22 06:40 AM
what's that
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ibtisam.midlet 05-Sep-22 06:40 AM
Surrogate
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Free Will I Am 05-Sep-22 06:41 AM
Oh
06:41
Thought we were talking about cloning
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ibtisam.midlet 05-Sep-22 06:41 AM
Between dog cloning is 50k
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veganpermanently 05-Sep-22 06:41 AM
yeah some wrecked bitch eating mcdonalds and sitting on her ass getting 100k for pushing out a baby once a year
☝️ 1
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Free Will I Am 05-Sep-22 06:42 AM
Get real lol
06:42
She ain't getting a dime unless she's in shape
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veganpermanently 05-Sep-22 06:42 AM
she ain't getting a dime if she can't keep up on the bike
👌 1
🍍 1
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Free Will I Am 05-Sep-22 06:43 AM
You know it brother
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ibtisam.midlet 05-Sep-22 06:43 AM
Someone contract the dog cloning company
06:43
get us some info about human one
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Free Will I Am 05-Sep-22 06:43 AM
She needs to keep up with me on my runs
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Free Will I Am
She needs to keep up with me on my runs
veganpermanently 05-Sep-22 06:46 AM
put her mitochondria to a test
emoji_12 1
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ibtisam.midlet 05-Sep-22 07:58 AM
This is the pet cloning company
07:58
https://www.viagenpets.com/
ViaGen Pets | America's Pet Cloning Experts
Extend the special bond with your beloved pet. ViaGen Pets is America’s pet cloning and genetic preservation experts. Contact ViaGen at 1-888-876-6104.
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07:59
Cat cost 35k
07:59
the cloned cat
08:00
08:00
left (original) Right (cloned)
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ibtisam.midlet
Cat cost 35k
veganpermanently 05-Sep-22 08:02 AM
tell them issa monkey you just need an embrio send them your cells
😂 1
08:02
emoji_50
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ibtisam.midlet
Click to see attachment 🖼️
Yana 05-Sep-22 08:34 AM
IS that dog just a husky
08:35
So cool
975956931392983070 1
❤️ 1
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Yana
IS that dog just a husky
ibtisam.midlet 05-Sep-22 08:39 AM
Yeah
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Yana 05-Sep-22 08:40 AM
Cat cost 35k lol
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ibtisam.midlet
Click to see attachment 🖼️
Ffff ./ 05-Sep-22 11:24 AM
Cat + Some kind of thing (edited)
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ibtisam.midlet
Between dog cloning is 50k
ExileMage 05-Sep-22 11:59 AM
Jfc the procedure is so simple it could be done in a fucking kitchen, and it costs 50k?
11:59
Scientists are the real Jews.
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ExileMage
Jfc the procedure is so simple it could be done in a fucking kitchen, and it costs 50k?
Pax1l 05-Sep-22 02:34 PM
Are you serious😂
14:34
Bare minimum should cost tens of thousands
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ibtisam.midlet
Someone contract the dog cloning company
Netizenne 05-Sep-22 05:25 PM
We need to get some friends on the inside (edited)
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ibtisam.midlet 05-Sep-22 10:44 PM
@𝔘𝔵𝔨ü𝔩𝔩 sorry but CBT is not allowed under any circumstances
👍 1
22:44
you should post sleep cycles explanation alone
22:45
❤
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ExileMage
Jfc the procedure is so simple it could be done in a fucking kitchen, and it costs 50k?
veganpermanently 06-Sep-22 03:31 AM
I have a kitchen lmk the recipe
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Netizenne 06-Sep-22 09:51 AM
What do you guys think of energy homeostasis -the push and pull of energy intake and expenditure? Can it be hacked for nootropic purposes? (edited)
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Netizenne
What do you guys think of energy homeostasis -the push and pull of energy intake and expenditure? Can it be hacked for nootropic purposes? (edited)
ibtisam.midlet 06-Sep-22 10:35 AM
I think nit that r selection = more energy intake (or trying to do), less spending Due the uncaring parent (attention deficited parent I meant) the only think the organizem think of was food , the body spend less energy as he can to accumulate the rest as fat, until the next meal (mean next month hehe) opposite of k
10:36
-can it be hacked for nootropic proposes keto diet
10:36
As for preprogrammed fixed weight, it can be alerted as long as the change in the variables exist
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ibtisam.midlet
I think nit that r selection = more energy intake (or trying to do), less spending Due the uncaring parent (attention deficited parent I meant) the only think the organizem think of was food , the body spend less energy as he can to accumulate the rest as fat, until the next meal (mean next month hehe) opposite of k
Netizenne 06-Sep-22 10:41 AM
Yea oxytocin which generally promotes K selected traits happens to suppress appetite.
10:41
Also I think K selected organisms might have less raw instincts in general -being more reliant on parental investment to teach them behaviour.?
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Netizenne 06-Sep-22 10:56 AM
After consulting here I responded to him like this
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Netizenne
Also I think K selected organisms might have less raw instincts in general -being more reliant on parental investment to teach them behaviour.?
ibtisam.midlet 06-Sep-22 10:58 AM
Yeah seems neat, there should be an oxytocin-mediated dominance in organism unconscious make them follow parents
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Netizenne 06-Sep-22 11:02 AM
I found this quote on Wikipedia
The term homeostatic plasticity derives from two opposing concepts: 'homeostatic' (a product of the Greek words for 'same' and 'state' or 'condition') and plasticity (or 'change'), thus homeostatic plasticity means "staying the same through change".
11:03
https://en.wikipedia.org/wiki/Homeostatic_plasticity kind of an unrelated topic but that quote happens to explain the dichotomy of plasticity and homeostasis. still neat rabbit hole with lots of links to get lost in in its own right. Synaptic scaling looks cool (edited)
Homeostatic plasticity
In neuroscience, homeostatic plasticity refers to the capacity of neurons to regulate their own excitability relative to network activity. Homeostatic synaptic plasticity is a means of maintaining the synaptic basis for learning, respiration, and locomotion, in contrast to the Hebbian plasticity associated with learning and memory. Although Hebb...
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ibtisam.midlet 06-Sep-22 11:15 AM
genome don't force how you are, but he give a incapacitate terms to go against it
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ibtisam.midlet
Yeah seems neat, there should be an oxytocin-mediated dominance in organism unconscious make them follow parents
ibtisam.midlet 06-Sep-22 11:20 AM
"unconscious" to overcome instincts also awareness one to follow parent in rest things, like my parent care for me, so i follow them, this will not possible if you try to follow parent opinion when he is against a instinct
11:21
because unconscious dominance behavioral execution, causing compulsive behaviors
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Netizenne
https://en.wikipedia.org/wiki/Homeostatic_plasticity kind of an unrelated topic but that quote happens to explain the dichotomy of plasticity and homeostasis. still neat rabbit hole with lots of links to get lost in in its own right. Synaptic scaling looks cool (edited)
ibtisam.midlet 06-Sep-22 11:33 AM
-still neat rabbit hole look at me off risperidone you will see few k opened firefox tabs emoji_52
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ibtisam.midlet
-still neat rabbit hole look at me off risperidone you will see few k opened firefox tabs emoji_52
Netizenne 06-Sep-22 11:42 AM
Lmfao I often have multiple full windows of tabs xddddddd
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ibtisam.midlet 06-Sep-22 11:44 AM
i need to return to Dopamine 1 agonists research
11:44
goal directed behaviors is everything
11:46
you don't open a link, if it's not toward solving the problem you started searching for
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ibtisam.midlet
you don't open a link, if it's not toward solving the problem you started searching for
veganpermanently 06-Sep-22 11:52 AM
that's autistic
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veganpermanently
that's autistic
ibtisam.midlet 06-Sep-22 11:53 AM
i dream to be autistic better then perfectionism (edited)
11:53
elon is lucky
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ibtisam.midlet
elon is lucky
veganpermanently 06-Sep-22 11:53 AM
Elon is narcissistic not autistic
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veganpermanently
Elon is narcissistic not autistic
ibtisam.midlet 06-Sep-22 11:54 AM
he is straightforward and people don't like straightforwardness
11:55
asperge emoji_7
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veganpermanently 06-Sep-22 11:55 AM
it is easy to recognize a narcissist
11:56
and asperger's is resistant to this state
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ibtisam.midlet 06-Sep-22 11:57 AM
narcissism is smartness
11:58
just label your relationships
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veganpermanently 06-Sep-22 11:58 AM
no it is weakness by definition
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veganpermanently
and asperger's is resistant to this state
Weeking 06-Sep-22 12:16 PM
As an autistic person I agree, though I believe they could rather be vulnerable narcissistic, if anything. (edited)
💯 1
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Weeking
As an autistic person I agree, though I believe they could rather be vulnerable narcissistic, if anything. (edited)
veganpermanently 06-Sep-22 12:17 PM
maybe depending on nurture but Elon is the polar opposite anyways. But still it is kinda hard to imagine a dependent Aspie
12:19
https://www.youtube.com/watch?v=5MSfHDF2T7o
Joe’s Dojo
I’m autistic as shit
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veganpermanently
Elon is narcissistic not autistic
Yana 06-Sep-22 12:34 PM
Autism = αυτος = with resepect to oneself-ism
💟 4
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Netizenne 06-Sep-22 01:10 PM
I want to flesh out evidence for my conception on ego at some point. That ego defensiveness = trying to keep mental networks they’ve invested a lot time and energy into relevant (either by repurposing it or by keeping their environment around them reliant on them even if wrong). So in such case then, larger ego = larger domain of mental frameworks invested. And ego defensiveness results from the validity of their mental investments being challenged.
13:12
Thinking about it this way, while autists aren’t necessarily weighted with ego defensiveness (like narcissists are) -they do have large egos (large mental frameworks they’ve invested in). (edited)
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Netizenne
I want to flesh out evidence for my conception on ego at some point. That ego defensiveness = trying to keep mental networks they’ve invested a lot time and energy into relevant (either by repurposing it or by keeping their environment around them reliant on them even if wrong). So in such case then, larger ego = larger domain of mental frameworks invested. And ego defensiveness results from the validity of their mental investments being challenged.
judas 06-Sep-22 01:12 PM
Sounds like the sunk cost fallacy
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judas
Sounds like the sunk cost fallacy
Netizenne 06-Sep-22 01:12 PM
There’s a lot of research on the neural bases of biases which this way of thinking about ego lends itself really well to
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veganpermanently 06-Sep-22 01:14 PM
I want to flesh out evidence to disprove the whole DSM 5 once and for all, tho' I'm not invested enough and I like to see the world burn anyways so I'd rather keep cycling to heaven and back
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Netizenne
Thinking about it this way, while autists aren’t necessarily weighted with ego defensiveness (like narcissists are) -they do have large egos (large mental frameworks they’ve invested in). (edited)
Netizenne 06-Sep-22 01:14 PM
Ego defensiveness is about maintaining efficient use of energy at the core of it. Everything evolved to maintain as efficient use of energy as possible. (edited)
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veganpermanently
I want to flesh out evidence to disprove the whole DSM 5 once and for all, tho' I'm not invested enough and I like to see the world burn anyways so I'd rather keep cycling to heaven and back
Netizenne 06-Sep-22 01:15 PM
lol rip
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Weeking 06-Sep-22 01:15 PM
It's not like DSM is really relevant anyway
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veganpermanently 06-Sep-22 01:16 PM
https://www.youtube.com/shorts/-JNyJY2a3I4
ViralHog
Man Apparently Falls Asleep While Riding Bike || ViralHog
13:16
me after 400 km non stop marathon
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Netizenne
Thinking about it this way, while autists aren’t necessarily weighted with ego defensiveness (like narcissists are) -they do have large egos (large mental frameworks they’ve invested in). (edited)
Netizenne 06-Sep-22 01:16 PM
Autists large ego manifests as large cortexes, and their resistance to change is represented by their impaired synaptic pruning.
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veganpermanently 06-Sep-22 01:17 PM
kek my cousin is autist the idiots diagnosed shizophrenia
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Weeking 06-Sep-22 01:17 PM
There is a video of a schizophrenic autist (edited)
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MEE6 BOT 06-Sep-22 01:17 PM
@Weeking, you have advanced to lvl 1 respect++ emoji_51
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veganpermanently 06-Sep-22 01:18 PM
u cannot possibly be shizophrenic at 140 IQ
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Weeking 06-Sep-22 01:18 PM
I heard schizophrenic is the opposite, too much pruning (edited)
13:18
so it would be both?
13:18
in that case
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Netizenne
I want to flesh out evidence for my conception on ego at some point. That ego defensiveness = trying to keep mental networks they’ve invested a lot time and energy into relevant (either by repurposing it or by keeping their environment around them reliant on them even if wrong). So in such case then, larger ego = larger domain of mental frameworks invested. And ego defensiveness results from the validity of their mental investments being challenged.
Netizenne 06-Sep-22 01:18 PM
@Blossoming Tree of Peace You should try seeing if you can understand your articles on narcissism from this perspective? Or maybe you have interesting finds from your research on narcissism to contribute to this? (edited)
emoji_52 1
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veganpermanently 06-Sep-22 01:19 PM
funnything the guy accepted the diagnosis and took the drugs
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Weeking
I heard schizophrenic is the opposite, too much pruning (edited)
Netizenne 06-Sep-22 01:20 PM
Schizophrenic paranoia could be interpreted as insecurity. Maybe they could be unable to invest too much mental thought to something out of fear maybe, though that doesn’t seem right. (edited)
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veganpermanently 06-Sep-22 01:20 PM
first time seeing him exhibit fallacious thinking
13:22
psychology and psychiatry is garbage
📠 1
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veganpermanently
psychology and psychiatry is garbage
Weeking 06-Sep-22 01:23 PM
Oh a hot-take, I see. (edited)
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veganpermanently 06-Sep-22 01:23 PM
when you look at the study quality and compare to neurochemistry
13:23
there is no point to even read that shit
13:23
just burn it all and start again
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Yana
Autism = αυτος = with resepect to oneself-ism
Free Will I Am 06-Sep-22 01:24 PM
🔥
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Weeking 06-Sep-22 01:25 PM
I mean maybe, but there are interesting constructs still.
13:26
in the end some people find themselves in PD's.
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veganpermanently 06-Sep-22 01:26 PM
yeah the vague patterns seem okay but still can't do anything with it
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🌈Ritalin&Rainbows🌈 06-Sep-22 03:23 PM
edgy_dab
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Netizenne
@Blossoming Tree of Peace You should try seeing if you can understand your articles on narcissism from this perspective? Or maybe you have interesting finds from your research on narcissism to contribute to this? (edited)
qwerkyscience 06-Sep-22 03:28 PM
Where are his articles on narcissism
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veganpermanently
psychology and psychiatry is garbage
qwerkyscience 06-Sep-22 03:29 PM
Religion. Professional scientific astrology
emoji_12 1
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qwerkyscience
Where are his articles on narcissism
Free Will I Am 06-Sep-22 03:32 PM
Totally unrelated to the topic but: don't you have a server?
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qwerkyscience 06-Sep-22 03:32 PM
Yes
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Free Will I Am 06-Sep-22 03:32 PM
I think I'm on it with my old account but lost it
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qwerkyscience 06-Sep-22 03:32 PM
https://discord.gg/RaEVwFtBHK
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Free Will I Am 06-Sep-22 03:32 PM
👍
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🌈Ritalin&Rainbows🌈 06-Sep-22 04:10 PM
⬇️
16:11
I wanna go back to just shitpost but I better not
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ibtisam.midlet
-still neat rabbit hole look at me off risperidone you will see few k opened firefox tabs emoji_52
Yana 06-Sep-22 05:38 PM
prl-8-53 does this to me emoji_27
emoji_1 1
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qwerkyscience
Where are his articles on narcissism
Netizenne 06-Sep-22 05:46 PM
They were compiling a list of studies with some annotated notes a while back
17:47
I’ll invite you to their server!!!!!!!!!!
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Yana
prl-8-53 does this to me emoji_27
ibtisam.midlet 06-Sep-22 09:44 PM
interesting
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ibtisam.midlet 06-Sep-22 10:23 PM
I ship yana!
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Yana
prl-8-53 does this to me emoji_27
veganpermanently 06-Sep-22 11:58 PM
Armoda roflmao
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Chad Thundercock 07-Sep-22 05:00 AM
What is this
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🌈Ritalin&Rainbows🌈 07-Sep-22 09:34 AM
Why are the emojis here android emojis
09:34
Kys
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ibtisam.midlet 07-Sep-22 10:16 AM
because they are cuter
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Auwii 07-Sep-22 11:39 AM
Blobs are cute emoji_49
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Free Will I Am 07-Sep-22 11:39 AM
No u
11:39
C'mere
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Auwii 07-Sep-22 11:40 AM
emoji_49
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Free Will I Am 07-Sep-22 11:42 AM
emoji_13 995525573067677707
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Auwii
emoji_49
Netizenne 07-Sep-22 11:58 AM
boywave emoji_4 (edited)
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MEE6 BOT 07-Sep-22 11:58 AM
@Netizenne, you have advanced to lvl 10 respect++ emoji_51
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Auwii 07-Sep-22 11:58 AM
975956931392983070
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Netizenne 07-Sep-22 11:58 AM
Waow
11:59
emoji_50
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Netizenne
emoji_50
Netizenne 07-Sep-22 11:59 AM
Oh this one’s pretty good yay (edited)
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Auwii 07-Sep-22 12:04 PM
Oh, yeah, looks nice
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Free Will I Am 07-Sep-22 11:21 PM
Wait wtf since when did discord implement forums?
23:24
!
Image attachment
Image attachment
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Chad Thundercock 07-Sep-22 11:25 PM
Is this a furry server
23:26
Because if not I'm not interested
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Free Will I Am 07-Sep-22 11:26 PM
I only ever join furry servers friend come on now
23:26
I'm a man of class what do you take me for?
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Free Will I Am
Wait wtf since when did discord implement forums?
ibtisam.midlet 08-Sep-22 12:03 AM
its copiing guilded features
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Chad Thundercock 08-Sep-22 12:03 AM
Goodbye sir
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ibtisam.midlet 08-Sep-22 12:14 AM
I was in a real forum before and they was mad because users switched to chating platform, and they seems not catche it
00:16
Now chating platforms are going to implement the organized feeling of forums
00:16
Its funny how internet started returning to past days of apps instead of sites emoji_1
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Free Will I Am 08-Sep-22 12:22 AM
We need a free software platform that can bridge all these mainstream botnet sites that's what I want to see the most
00:23
Something that can eventually catch up to the innovation of proprietary software
00:23
We need a large enough movement of free software propagators to make it happen
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ibtisam.midlet
Now chating platforms are going to implement the organized feeling of forums
ibtisam.midlet 08-Sep-22 12:24 AM
IMO there should be some sort of severe simplicity here Netizzen are correct
00:26
and the organized data should be in Wikipedia/some sort of searching tools
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Free Will I Am 08-Sep-22 12:26 AM
I don't like how much control a set few companies have over the average person's communication. It limits discourse and encourages mincing of words even among adults
💟 2
00:26
We need free and open self-hostable platforms
00:26
Something that isn't too hard for a normal person to setup
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Free Will I Am
We need a large enough movement of free software propagators to make it happen
ibtisam.midlet 08-Sep-22 12:27 AM
Someone need to update matrix GUI
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ibtisam.midlet
Someone need to update matrix GUI
Free Will I Am 08-Sep-22 12:27 AM
Maybe, I don't know if matrix is the best protocol for this but it's a start
00:27
XMPP is to underdeveloped but I think it's a better model in concept
00:28
The contribution is just too small
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Free Will I Am
We need free and open self-hostable platforms
ibtisam.midlet 08-Sep-22 12:28 AM
rocketchat is neat, just protocolize it to matrix
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Free Will I Am 08-Sep-22 12:28 AM
Whatsapp saw the potential of XMPP then hired devs build on top of it
💟 1
00:29
But it's proprietary which automatically sucks
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ibtisam.midlet 08-Sep-22 12:29 AM
all of those are JavaScript based
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Free Will I Am 08-Sep-22 12:29 AM
Then you have discord that's hosted on Google servers
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ibtisam.midlet 08-Sep-22 12:30 AM
Its will not he hard really for some fluent JavaScript speakers
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Free Will I Am
Then you have discord that's hosted on Google servers
ibtisam.midlet 08-Sep-22 12:30 AM
How
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Free Will I Am 08-Sep-22 12:33 AM
I went through the ToS and Guidelines unlike most people
00:33
It's stated clearly
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Free Will I Am
Whatsapp saw the potential of XMPP then hired devs build on top of it
ibtisam.midlet 08-Sep-22 12:33 AM
Never used xmpp BTW how it looks like
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Free Will I Am 08-Sep-22 12:38 AM
Janky last time I checked if I'm being 100% honest. There's simply not enough innovative development to be a viable replacement or even to integrate as bridge for the less demanding of users. There's no voice chat system. It is barebones and barely meets the needs required to be a functional chat application. Don't expect many features available. The positive aspects are that it's very customisable as you can add extensions which you can choose to add or remove to your self hosted instance and if the extension you add is competent enough then it can be adopted by the entire network
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MEE6 BOT 08-Sep-22 12:38 AM
@Free Will I Am, you have advanced to lvl 8 respect++ emoji_51
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Free Will I Am 08-Sep-22 12:39 AM
It's just that not a lot has been added to it over the past almost 20 years it's been about other than from private companies that have taken the base model and added their own proprietary UI on top of it
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Free Will I Am
Janky last time I checked if I'm being 100% honest. There's simply not enough innovative development to be a viable replacement or even to integrate as bridge for the less demanding of users. There's no voice chat system. It is barebones and barely meets the needs required to be a functional chat application. Don't expect many features available. The positive aspects are that it's very customisable as you can add extensions which you can choose to add or remove to your self hosted instance and if the extension you add is competent enough then it can be adopted by the entire network
Free Will I Am 08-Sep-22 12:41 AM
Another positive aspect is the Tor compatibility feature for the more privacy conscious (edited)
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Free Will I Am
It's just that not a lot has been added to it over the past almost 20 years it's been about other than from private companies that have taken the base model and added their own proprietary UI on top of it
Free Will I Am 08-Sep-22 12:44 AM
Over* 20 years
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ibtisam.midlet 08-Sep-22 12:51 AM
helpfull software
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Free Will I Am
Over* 20 years
ibtisam.midlet 08-Sep-22 12:51 AM
due to nature of open sourceness , projects get rebranded with other names, with some loss in functionality especially add-ons
☝️ 1
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Free Will I Am 08-Sep-22 12:52 AM
Companies refine it to fit their purposes
💟 1
00:53
It's understandable. I personally don't want to live in a world where my communication is at the mercy of a select few companies. It's bad enough that we are at the mercy of our ISP to some extent
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Free Will I Am
It's understandable. I personally don't want to live in a world where my communication is at the mercy of a select few companies. It's bad enough that we are at the mercy of our ISP to some extent
Free Will I Am 08-Sep-22 12:54 AM
There's ways to hide activity from them but it's not fool proof
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Free Will I Am
There's ways to hide activity from them but it's not fool proof
ibtisam.midlet 08-Sep-22 12:55 AM
tor need to be one click option
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Free Will I Am 08-Sep-22 12:59 AM
That's available on XMPP apps natively. Good luck getting that feature on any proprietary application. Twitter has only recently added its own onion link. Pretty much all of them are hesitant to support it because it's not in their best interests to promote privacy of the individual (edited)
👍 1
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ibtisam.midlet 08-Sep-22 01:01 AM
What do you think free software with ads Or paid software without them
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Free Will I Am 08-Sep-22 01:03 AM
Ideally free software with donations with the option for ads that the user selects rather than basic or targeted ads by default (unless the user wants to opt-in)
01:04
So you have an ad profile that you submit and then it caters to that (edited)
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ibtisam.midlet 08-Sep-22 01:06 AM
Paid piratable app IMO
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Free Will I Am 08-Sep-22 01:07 AM
And instead of the of the current feedback model for content I would have personal sets of groups that can interact with content and videos so you can get a better idea of what demographics like certain content compared to just the entire set with the option to feed that into a larger pool of groups to compare
01:08
Take the concept of RSS feeds and expand it
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Free Will I Am
Take the concept of RSS feeds and expand it
ibtisam.midlet 08-Sep-22 01:09 AM
Yes some stuff like ipfs will never beat torrent rate system
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Free Will I Am 08-Sep-22 01:11 AM
That way you are not just seeing (oh the majority of people hate this video) it's the majority dislike and the THIS specific group likes this but THIS other group hates it. If they choose not to be an anonymous submission ofc
01:12
This is something that could be made very complex
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Free Will I Am
That way you are not just seeing (oh the majority of people hate this video) it's the majority dislike and the THIS specific group likes this but THIS other group hates it. If they choose not to be an anonymous submission ofc
ibtisam.midlet 08-Sep-22 01:12 AM
I hate seeing CBT stuff on the daily emoji_28
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ibtisam.midlet
I hate seeing CBT stuff on the daily emoji_28
Free Will I Am 08-Sep-22 01:13 AM
I gathered lol
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Free Will I Am 08-Sep-22 01:23 AM
Imagine you have a set group of people who all contribute to pools that have their submissions anonymized (verified as human somehow) cryptographically and sent off to data analytics companies and given some suitable advertisements which they could also potentially earn money from as well as the creator of content they're watching from depending on their total watch time. All of this done using some extension protocol. I think brave has a very simplistic feature which somewhat touches upon that idea
01:24
With this, you could add it to any content hosting site of your choice
01:26
You would have to verify how many ads you watch etc to the pool and the pool would need to be responsible that you aren't exploiting it somehow
01:30
Essentially you would split the money between the individual, pool, content creator and server host. (You can include the protocol devs for free software if you wanna be fair) The server host would more than likely be prioritized as they hold the most responsibility but it may depend on the value of the pool itself and the individuals that make up that pool (edited)
01:32
This would be invaluable for studying group behavior
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Free Will I Am 08-Sep-22 01:44 AM
We can bring back the 5 star system from old YouTube and have emotional reactions rather than the limited like and dislike. You can see comments that come from pools or you can choose to represent your hosted server or all 3 or none. The options are practically endless. All on free and open platforms like peertube or even lbry even though I don't like lbry that much
01:45
Self-Hosting > Blockchain hosting > Big corpo hosting (edited)
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Free Will I Am 08-Sep-22 02:27 AM
With pools, it also potentially fixes the issue of revenue determining video recommendations as ads are targeting pools and individuals determine whether or not to turn on ads for a video (unless hosts and/or creators mandate it)
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Free Will I Am
We can bring back the 5 star system from old YouTube and have emotional reactions rather than the limited like and dislike. You can see comments that come from pools or you can choose to represent your hosted server or all 3 or none. The options are practically endless. All on free and open platforms like peertube or even lbry even though I don't like lbry that much
veganpermanently 08-Sep-22 02:35 AM
aside from the fact that these services have little to no valuable members they also have lousy GUIs to the point it hurts my eyes
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veganpermanently
aside from the fact that these services have little to no valuable members they also have lousy GUIs to the point it hurts my eyes
Free Will I Am 08-Sep-22 02:36 AM
Yeah they suck rn. This is why the software needs to improve
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veganpermanently 08-Sep-22 02:36 AM
also they have bad algorhythms which greatly reduces watch time for each user
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Free Will I Am 08-Sep-22 02:37 AM
Building pools algorithms with feedback would be useful for these platforms
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veganpermanently 08-Sep-22 02:37 AM
all of this causes the valuable member to just post on utube or watever bcs they see no value in alternatives unless they're being censored all the time and can't cope with it
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Free Will I Am 08-Sep-22 02:37 AM
Any user can join a pool and it can have its own recommendation algorithm to fit their niches
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veganpermanently 08-Sep-22 02:38 AM
IMO since it's decentralized I don't see the reason why it doesn't just copy the GUI of youtube
02:38
could even steal the algorhythm lol
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veganpermanently
all of this causes the valuable member to just post on utube or watever bcs they see no value in alternatives unless they're being censored all the time and can't cope with it
Free Will I Am 08-Sep-22 02:39 AM
I'd like to at some point scrape YouTube channels and upload to a self hosted onion based (so I don't get sued) peertube-like instance
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veganpermanently
IMO since it's decentralized I don't see the reason why it doesn't just copy the GUI of youtube
Free Will I Am 08-Sep-22 02:40 AM
They could target any self hosted instances that have clearnet addresses
02:41
Unless you host in some politically neutral country
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Free Will I Am
They could target any self hosted instances that have clearnet addresses
veganpermanently 08-Sep-22 02:41 AM
yeah it would be cool to create an algorhythm that combines algorhythms of various services
02:42
like just use their output and filter it according to user engagement
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Free Will I Am 08-Sep-22 02:43 AM
With pools, those possibilities become endless because you can take the consensus of said pool and recommend based on that consensus. You could also contribute to more than one pool* (as a user) potentially (edited)
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veganpermanently
like just use their output and filter it according to user engagement
Free Will I Am 08-Sep-22 02:43 AM
Exactly
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Free Will I Am
With pools, those possibilities become endless because you can take the consensus of said pool and recommend based on that consensus. You could also contribute to more than one pool* (as a user) potentially (edited)
Free Will I Am 08-Sep-22 02:45 AM
Take that data from a number of pools that are trustworthy and then you can see the overall engagement of videos. You could even link that same video to every platform it's hosted on (if it's multi-platform)
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veganpermanently 08-Sep-22 02:46 AM
https://www.youtube.com/watch?v=fyPnx_Iv4bE&list=RDjrZ-G_ROLs4
Blah Records
Mcabre Brothers (Lee Scott x Milkavelli) - INABIT (prod. Jack Danz)...
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veganpermanently
https://www.youtube.com/watch?v=fyPnx_Iv4bE&list=RDjrZ-G_ROLs4
Free Will I Am 08-Sep-22 02:52 AM
Rate it
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Free Will I Am
Take that data from a number of pools that are trustworthy and then you can see the overall engagement of videos. You could even link that same video to every platform it's hosted on (if it's multi-platform)
Free Will I Am 08-Sep-22 02:55 AM
And I say trustworthy because there will definitely be groups out there who try to produce artificial engagement
02:56
If one person joins a pool and watches the same video 100+ times e.g sleeps with the video on repeat then does it count?
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veganpermanently
https://www.youtube.com/watch?v=fyPnx_Iv4bE&list=RDjrZ-G_ROLs4
Free Will I Am 08-Sep-22 03:14 AM
https://www.youtube.com/watch?v=N5SelLQ869o
WORLD PENG
"SPLIFTED" - Humble Pious ft Darkus Jahvey (prod. Remulak) [Officia...
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Free Will I Am
https://www.youtube.com/watch?v=N5SelLQ869o
veganpermanently 08-Sep-22 05:09 AM
mid
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Yana 08-Sep-22 05:39 AM
Rocketchat was a good choice by gintrux, I'd say. All you need is an account on that server and you don't have to download anything or deal with some other meta-system rather than just talking on the server. You just send people the damn link
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veganpermanently
mid
Free Will I Am 08-Sep-22 06:37 AM
It is
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Free Will I Am
It is
veganpermanently 08-Sep-22 06:57 AM
emoji_52
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MEE6 BOT 08-Sep-22 06:57 AM
@veganpermanently, you have advanced to lvl 12 respect++ emoji_51
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Leonardo Ruilova BOT 08-Sep-22 04:38 PM
I recommend www.dino.im as a XMPP messaging client
16:38
With messaging server from jabber.ccc.de
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ibtisam.midlet 09-Sep-22 02:17 AM
@Pax1l https://pubmed.ncbi.nlm.nih.gov/18986766/ what's the function of ubiquitin/proteasome
Inhibition of the ubiquitin-proteasome activity prevents glutamate ...
Glutamate transporters play a crucial role in physiological glutamate homeostasis and neurotoxicity. Recently, we have shown that downregulation of glutamate transporters after chronic morphine exposure contributed to the development of morphine tolerance. In the present study, we examined whether r …
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02:19
https://molpharm.aspetjournals.org/content/early/2021/05/24/molpharm.120.000211
ABIN-1 in the brain alleviated opioid tolerance through its action ...
Opioids play an important role in pain relief, but repeated exposure results in tolerance and dependence. To make opioids more effective and useful, research in the field has focused on reducing the tolerance and dependence for chronic pain relief. Here, we showed the effect of ABIN-1 in modulating morphine function. We used hotplate tests and C...
02:20
"ABIN-1-β-arrestin2 complexes, which accelerate β-arrestin2 degradation by ubiquitination"
02:21
whats this new keyword "ubiquitination"
02:22
i found you talk about it in one of your wots
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MEE6 BOT 09-Sep-22 02:22 AM
@ibtisam.midlet, you have advanced to lvl 17 respect++ emoji_51
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ibtisam.midlet
@Pax1l https://pubmed.ncbi.nlm.nih.gov/18986766/ what's the function of ubiquitin/proteasome
veganpermanently 09-Sep-22 02:27 AM
it controls degradation, activation and tissue selectivity of proteins independent from expression
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veganpermanently
it controls degradation, activation and tissue selectivity of proteins independent from expression
ibtisam.midlet 09-Sep-22 02:29 AM
seems strong target
02:30
it even modulated glutamate upregulation mediated tolerance, which beta arrestin don't
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ibtisam.midlet
seems strong target
veganpermanently 09-Sep-22 02:31 AM
well yeah if you can find well researched enzymes to target, in general saying it's a strong target is kinda like saying phosphorylation is a strong target... Yeah, but it means nothing
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veganpermanently
well yeah if you can find well researched enzymes to target, in general saying it's a strong target is kinda like saying phosphorylation is a strong target... Yeah, but it means nothing
ibtisam.midlet 09-Sep-22 02:31 AM
not when you mix it with paroxetine
02:35
in my experience with substance that inhibit tolerance, they don't cause upregulation, it just prevent downregulation, so don't expect any effect
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ibtisam.midlet
not when you mix it with paroxetine
ibtisam.midlet 09-Sep-22 02:40 AM
beta arrestin inhibitor in ~30mg+ dose, tested and found that the time you are on it considered tolerance break
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ibtisam.midlet 09-Sep-22 03:30 AM
does anyone has suicidal reddit account
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ibtisam.midlet
does anyone has suicidal reddit account
Weeking 09-Sep-22 03:33 AM
?
😂 2
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ibtisam.midlet 09-Sep-22 03:46 AM
Found out reddit users use discord
03:46
Spamming them will bring some genuines
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ibtisam.midlet
Found out reddit users use discord
Free Will I Am 09-Sep-22 03:46 AM
Majority of the userbase
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ibtisam.midlet 09-Sep-22 04:39 AM
Image attachment
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ibtisam.midlet
Click to see attachment 🖼️
Weeking 09-Sep-22 04:40 AM
Is it you?
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ibtisam.midlet
https://molpharm.aspetjournals.org/content/early/2021/05/24/molpharm.120.000211
machineyadav 09-Sep-22 04:44 AM
I am collecting list of substances that prevents morphine/opioid tolerance
04:44
And make pathways and big chart
04:44
NMDA antagonist, CCK antagonist, one compound shared by @Pax1l also prevents opiods tolerance, i forgot name and mechanism of actions
04:45
Iron also is somehow involved in tolerance
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Blossoming Tree of Peace 09-Sep-22 04:48 AM
Quercetin reverses opioid tolerance
04:48
Ultra low dose naltrexone too
👍 2
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Weeking
Is it you?
ibtisam.midlet 09-Sep-22 04:53 AM
nope but @Sexy Seojin seen me on/off estrogen
😏 1
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machineyadav
And make pathways and big chart
ibtisam.midlet 09-Sep-22 04:55 AM
they will cross work with other targets
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machineyadav
Iron also is somehow involved in tolerance
Yana 09-Sep-22 05:15 AM
https://www.eneuro.org/content/6/4/ENEURO.0237-19.2019
Morphine-Induced Modulation of Endolysosomal Iron Mediates Upregula...
HIV-associated neurocognitive disorders (HAND) remain prevalent and are aggravated by µ-opioid use. We have previously shown that morphine and other µ-opioids may contribute to HAND by inhibiting the homeostatic and neuroprotective chemokine receptor CXCR4 in cortical neurons, and this novel mechanism depends on upregulation of the protein ferri...
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Yana
https://www.eneuro.org/content/6/4/ENEURO.0237-19.2019
ibtisam.midlet 09-Sep-22 05:42 AM
found more validating data https://pubs.acs.org/doi/10.1021/acschemneuro.9b00539
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machineyadav
NMDA antagonist, CCK antagonist, one compound shared by @Pax1l also prevents opiods tolerance, i forgot name and mechanism of actions
ibtisam.midlet 09-Sep-22 06:09 AM
put that in tolerance channel if you want
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veganpermanently 09-Sep-22 06:14 AM
leaf banned again?
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ibtisam.midlet
put that in tolerance channel if you want
machineyadav 09-Sep-22 06:27 AM
I will make a better list along with mechanical of action soon
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le_drig 09-Sep-22 07:10 AM
anyone know of AQP4?
07:10
know more about it
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le_drig
anyone know of AQP4?
veganpermanently 09-Sep-22 07:14 AM
almost forgot about this
07:14
it's a hard problem
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veganpermanently
leaf banned again?
🌈Ritalin&Rainbows🌈 09-Sep-22 07:32 AM
@Blossoming Tree of Peace
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ibtisam.midlet
nope but @Sexy Seojin seen me on/off estrogen
Netizenne 09-Sep-22 08:10 AM
Estrogen consumer??
08:11
What do you think about liquiritigenin, the selective estrogen receptor beta agonist? You at all very familiar with what to expect besides lower body fat distribution and maybe slightly darker skin?
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veganpermanently 09-Sep-22 08:12 AM
beta selective agonist/AR partial agonist castrato master race
😮 1
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Netizenne 09-Sep-22 08:12 AM
It doesn’t stop the deepening of voice if it’s already deepened tho? rip
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veganpermanently 09-Sep-22 08:13 AM
deep voice is useful
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Netizenne 09-Sep-22 08:14 AM
Is the partial AR agonist for reducing the receptors activity? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931200/ I was thinking this was interesting (edited)
Image attachment
08:15
While on the topic (edited)
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Netizenne
Is the partial AR agonist for reducing the receptors activity? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931200/ I was thinking this was interesting (edited)
veganpermanently 09-Sep-22 08:16 AM
partial agonist is to prevent sides from low AR signaling like reduced locomotion, mood and cognition, it also displaces stronger AR ligands like DHT which can help with prostate growth and hairloss
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Netizenne 09-Sep-22 08:16 AM
What can be taken for that.??
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veganpermanently 09-Sep-22 08:16 AM
it helps maintain muscle size during aging
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Netizenne 09-Sep-22 08:16 AM
Sounds pretty good
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veganpermanently 09-Sep-22 08:17 AM
and bone strength as well
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Netizenne
What can be taken for that.??
veganpermanently 09-Sep-22 08:17 AM
inbox
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ibtisam.midlet
nope but @Sexy Seojin seen me on/off estrogen
Sexy Seojin 09-Sep-22 09:10 AM
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Netizenne
What do you think about liquiritigenin, the selective estrogen receptor beta agonist? You at all very familiar with what to expect besides lower body fat distribution and maybe slightly darker skin?
ibtisam.midlet 09-Sep-22 09:57 AM
you can't expect everything from partial agonist, abilify which is dope 3 partial agonist caused risk avoidance (D3- effect) and increased libido (D3+)
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Netizenne
It doesn’t stop the deepening of voice if it’s already deepened tho? rip
ibtisam.midlet 09-Sep-22 09:58 AM
testosterone beat estrogen in this, you need to block testosterone and increase estrogen, to get that
10:00
the decrease on testosterone by estrogen intake is not enough, (concentration-mediated negative feedback against upregulation of AR receptors)
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Netizenne
Is the partial AR agonist for reducing the receptors activity? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931200/ I was thinking this was interesting (edited)
ibtisam.midlet 09-Sep-22 10:02 AM
look at SARM, you can get the androgen effect you want, with even antagonizing effect on other
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veganpermanently
almost forgot about this
le_drig 09-Sep-22 10:03 AM
why?
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le_drig
why?
veganpermanently 09-Sep-22 10:03 AM
because I have too much stuff on my plate biohacking wise, it's impossible to keep track of it all and keep researching everything simultaneously (edited)
10:04
I did try and it spiraled out of control within weeks. Now I have a more intuitive approach
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🌈Ritalin&Rainbows🌈 09-Sep-22 10:33 AM
What's the most effective AA
10:33
Current one only blocks DHT and not doing much of anything
10:33
I can fucking feel the t
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le_drig
why?
ibtisam.midlet 09-Sep-22 10:34 AM
sorry but i like to talk when i have something important to say, not saying inaccurate randome data Better let other one replay
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🌈Ritalin&Rainbows🌈
What's the most effective AA
ibtisam.midlet 09-Sep-22 10:34 AM
Primo
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🌈Ritalin&Rainbows🌈 09-Sep-22 10:35 AM
What
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MEE6 BOT 09-Sep-22 10:35 AM
@🌈Ritalin&Rainbows🌈, you have advanced to lvl 1 respect++ emoji_51
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🌈Ritalin&Rainbows🌈
What
ibtisam.midlet 09-Sep-22 10:39 AM
Metenolone enanthate
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🌈Ritalin&Rainbows🌈 09-Sep-22 10:39 AM
Ah ty
10:39
Wait this is an androgen
10:40
not antiandrogen?
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🌈Ritalin&Rainbows🌈
What's the most effective AA
Yana 09-Sep-22 10:43 AM
Winstrol, anadrol
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🌈Ritalin&Rainbows🌈 09-Sep-22 10:46 AM
Again
10:46
those are all androgens
10:46
???????
10:47
ANTI
10:47
Androgen
10:47
jfc
10:47
Morons
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ibtisam.midlet 09-Sep-22 10:48 AM
emoji_50
10:49
We use mental autocorrection which do mistakes sometimes
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veganpermanently
because I have too much stuff on my plate biohacking wise, it's impossible to keep track of it all and keep researching everything simultaneously (edited)
le_drig 09-Sep-22 01:02 PM
Interesting
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le_drig 09-Sep-22 01:16 PM
@ibtisam.midlet have you read about AQP4?
13:16
im trying to regulate its expression
13:16
melatonin does dose-dependently
13:16
E2 modulates it too
13:16
its why E2 helps in TBI recovery
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🌈Ritalin&Rainbows🌈
???????
Yana 09-Sep-22 02:38 PM
Your endogenous production will be shut down when you take them
14:39
Simple
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🌈Ritalin&Rainbows🌈
What's the most effective AA
JC Denton 09-Sep-22 02:39 PM
A swift kick in the balls
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Sexy Seojin 09-Sep-22 10:30 PM
🐤
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le_drig
@ibtisam.midlet have you read about AQP4?
ibtisam.midlet 10-Sep-22 12:18 AM
searched known indirect inhibitor doses https://onlinelibrary.wiley.com/doi/full/10.1111/j.1440-1681.2009.05244.x https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210660 can reduce edema in models of ischemia and traumatic brain injury at doses ranging from 15–30 mg/kg, too highest therapy dose is 2mg
Failure of bumetanide to improve outcome after intracerebral hemorr...
After intracerebral hemorrhage (ICH), brain edema commonly occurs and can cause death. Along with edema, there are significant alterations in the concentrations of key ions such as sodium, potassium, and chloride, which are essential to brain function. NKCC1, a cation-chloride cotransporter, is upregulated after brain damage, such as traumatic i...
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00:21
"Bumetanide was selected as the structural scaffold for design of a chemical library of derivatives based on a small but significant block of AQP4 water channel function" they try to make clinically relevant inhibitor based on it
00:24
intranasal can be effective
00:29
"Sleep quality, depth, and feeling of refreshment depend on the glymphatic system's ability to clear up the waste products that accumilate in your brain." anxiety being the major role, switching you off by blocking rem sleep, will productive route to solve this https://www.google.com/search?q=deep+sleep+inducing+peptide&oq=deep+sleep+pept&aqs=chrome.2.69i57j0i512j0i22i30l2j0i390l3.11163j0j7&sourceid=chrome&ie=UTF-8
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le_drig 10-Sep-22 12:30 AM
Cool
00:30
I was researching
💟 1
00:30
Estrogen and Melatonin regulate AQP4
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ibtisam.midlet 10-Sep-22 12:30 AM
targeting sleep cycles directly, that what i can help with
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le_drig 10-Sep-22 12:31 AM
How you do that
00:31
I have a great suspicioun
00:31
My Estrogen Receptor are downregulated in the brain, its why my sleep is never refreshing. AQP4 expression is downregulated
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ibtisam.midlet 10-Sep-22 12:32 AM
think about solving the problem fastly instead of perfectly
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le_drig 10-Sep-22 12:33 AM
I will
00:34
My regimen will be
00:35
Lithium Carbonate 900mg (HDACi) + Testosterone 100mg/week + Trenbolone 30mg EOD + Cabergoline daily
00:35
+ Shiljait (lowers serotonin)
00:35
Lithium Carbonate demethylates sex hormone receptor genes (should)
00:36
sounds like crazy stack but it should be fast stack not perfec t
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MEE6 BOT 10-Sep-22 12:36 AM
@le_drig, you have advanced to lvl 2 respect++ emoji_51
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le_drig 10-Sep-22 12:40 AM
This should upregulate AQP4
00:41
better estrogen signalling/androgen and there should be lower inflammation
00:41
more waste clearance and refreshing sleep aswell as better cognitive function
00:41
ER/AR is located in PFC and controls dopamine release
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ibtisam.midlet 10-Sep-22 12:52 AM
when magnesium kilo dose still not toleranced i was getting restful sleep and i don't get cognitive fatigue from a day 100% of work, it was like listening to music, blunting anxiety was inhibiting 80% of cognitive power needed to complete a task
00:52
causing me to work constantly due to me recover in the same speed of consuming the cognitive function
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le_drig 10-Sep-22 12:55 AM
Kilo dose?
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le_drig 10-Sep-22 02:45 AM
Can I add selegiline to abilify/rexulti/cabergoline?
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ibtisam.midlet 10-Sep-22 02:47 AM
nope
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le_drig 10-Sep-22 02:47 AM
Ok
02:48
Sure
02:48
I will just try other stuff
02:49
But Bromantane
02:49
should be ok
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ibtisam.midlet 10-Sep-22 02:52 AM
https://www.youtube.com/watch?v=_ysomCGaZLw&list=PLjSn4eT9KRsompqvxsPkxyMTW6Zn08WYa&index=144
JYP Entertainment
ITZY "마.피.아. In the morning" M/V @ITZY
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ibtisam.midlet 10-Sep-22 06:30 AM
https://m.haodf.com/neirong/wenzhang/167057.html
老年性痴呆药物治疗及注意事项 - 好大夫在线
治疗老年性痴呆的药物有哪些类别？目前治疗老年痴呆的药物主要有以下几类：1. 乙酰胆碱酯酶抑制剂（AChEI）：如他克林、多奈哌齐、重酒石酸卡巴拉汀、加兰他敏、石杉碱甲等；2. 谷氨酸受体（NMDA）调
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ibtisam.midlet 10-Sep-22 06:50 AM
https://pubmed.ncbi.nlm.nih.gov/20027370/
Tenoten in the therapy of patients with moderate cognitive impairme...
Tenoten is a new anxiolytic and antidepressant based on antibodies to brain-specific protein S-100B. Experimental studies demonstrated the effect of tenoten on mechanisms of neuronal plasticity and manifestations of higher nervous activity. Tenoten is clinically comparable with amitryptiline, sertra …
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06:50
https://www.sciencedirect.com/science/article/abs/pii/S0924933810704259
P01-219 - Clinical efficacy of tenoten for children in treatment of...
To assess efficacy and safety of tenoten for children (TC, ultra-low doses of antibodies to S100 protein) in ADHD patients.In a double-blind placebo-c…
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06:53
Anyone took that?
06:55
Its has signaficate efficacy in clinical trials for adhd and cognitive by acting as anxiolytic
06:56
And it is cheap https://nootropicsindex.com/nootropics/tenoten/
Tenoten Product Comparison | Nootropics Index
Find and compare prices for all Tenoten vendors worldwide or per region. Filter Tenoten products by type: capsules, powder or solution. Sort products by price per gram, price per capsule or product price. Show listed products based on their content and weight.
07:00
This seems the official site https://tenoten-deti.ru/about/
Тенотен детский - инструкция по применению
Чем отличается Тенотен детский от взрослого и с какого возраста его можно использовать? Все о препарате.
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07:01
prescripted for children (safe) for 3 months+ (works longterm)
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veganpermanently 10-Sep-22 07:50 AM
ibti have u trialed 4aminopyridine (edited)
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ibtisam.midlet 10-Sep-22 08:06 AM
Its listed as things I taken, but there is no report, means I did not get positive effect
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ibtisam.midlet
https://www.sciencedirect.com/science/article/abs/pii/S0924933810704259
ibtisam.midlet 10-Sep-22 08:16 AM
What ya all think about this @everyone emoji_50
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le_drig 10-Sep-22 08:21 AM
Interesting
08:21
do you know schisandra @ibtisam.midlet
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ibtisam.midlet
What ya all think about this @everyone emoji_50
machineyadav 10-Sep-22 08:25 AM
Targets unique protein S-100B
08:25
This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. In the developing CNS it acts as a neurotrophic factor and neuronal survival protein. In the adult organism it is usually elevated due to nervous system damage, which makes it a potential clinical marker.
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machineyadav
Targets unique protein S-100B
veganpermanently 10-Sep-22 08:27 AM
have u ever looked into endogenous DMT upregulation
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veganpermanently
have u ever looked into endogenous DMT upregulation
machineyadav 10-Sep-22 08:28 AM
Schizophrenia upregulates it
🤭 1
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veganpermanently 10-Sep-22 08:28 AM
Theoretically we could increase synthesis and decrease degradation of endogenous DMT. Reduction of tryptophan hydroxylase would create a shunt toward tryptamine biosynthesis which is then methylated twice by indole N methyl transferase to yield N,N DMT we all know and love but it is metabolized quickly by the monoamine oxidase A. If TPH is not inhibited serotonin is generated which can be methylated twice by the same enzyme to yield bufotenine which is even more potent that DMT, even 5MeO. Tryptamine is generated by the enzyme aromatic acid decarboxylase which is controlled by protein kinase A, the activity of which can be increased by a metabolite of compounds in Ceylon Cinnamon. Brain tryptophan availability can also be the bottle neck as it competes with BCAA for the same transporter. Methyl group availability may also be the bottle neck, S Adenosyl Methionine taking care of it. The receptors themselves can be insensitive or unheteromerized yielding no effect even with high DMT levels which is why some people have no response to psychedelics. Heteromerization can be promoted by simultaneous activation of both receptors and since mGluR2 agonists are unanavailable, best option would be prior treatment with the precursor L-glutamine. So theoretically Fasting or otherwise BCAA depletion with a low total protein diet for 5 days L-glutamine pretreatment Tryptophan supplementation and pretreatment Ceylon cinnamon Bifemelane Agomelatine S Adenosyl Methionine (edited)
08:28
came up with this today
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veganpermanently
Theoretically we could increase synthesis and decrease degradation of endogenous DMT. Reduction of tryptophan hydroxylase would create a shunt toward tryptamine biosynthesis which is then methylated twice by indole N methyl transferase to yield N,N DMT we all know and love but it is metabolized quickly by the monoamine oxidase A. If TPH is not inhibited serotonin is generated which can be methylated twice by the same enzyme to yield bufotenine which is even more potent that DMT, even 5MeO. Tryptamine is generated by the enzyme aromatic acid decarboxylase which is controlled by protein kinase A, the activity of which can be increased by a metabolite of compounds in Ceylon Cinnamon. Brain tryptophan availability can also be the bottle neck as it competes with BCAA for the same transporter. Methyl group availability may also be the bottle neck, S Adenosyl Methionine taking care of it. The receptors themselves can be insensitive or unheteromerized yielding no effect even with high DMT levels which is why some people have no response to psychedelics. Heteromerization can be promoted by simultaneous activation of both receptors and since mGluR2 agonists are unanavailable, best option would be prior treatment with the precursor L-glutamine. So theoretically Fasting or otherwise BCAA depletion with a low total protein diet for 5 days L-glutamine pretreatment Tryptophan supplementation and pretreatment Ceylon cinnamon Bifemelane Agomelatine S Adenosyl Methionine (edited)
machineyadav 10-Sep-22 08:29 AM
Wasn't DMT created in pineal gland from melatonin or pinealon
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machineyadav
Wasn't DMT created in pineal gland from melatonin or pinealon
veganpermanently 10-Sep-22 08:29 AM
maybe 5MeO
08:30
that would require deacetylization
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machineyadav 10-Sep-22 08:30 AM
I know one article said dark places for very long causes hallucinations because pineal gets activated
08:31
The metabolites become higher after 24+ hour (edited)
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veganpermanently 10-Sep-22 08:31 AM
the pathway I know of is Tryptophan >AADC> Tryptamine >INMT> NMT > INMT> N,N DMT
08:32
alternatively
08:32
Serotonin can be methylated twice to yield bufotenine
08:33
deacetylizing melatonin yields 5MeO Tryptamine which can be methylated twice again to yield 5MeO DMT (edited)
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le_drig 10-Sep-22 08:38 AM
@veganpermanently do you know about epigenetic methylation of SERT/AR/ER?
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le_drig
@veganpermanently do you know about epigenetic methylation of SERT/AR/ER?
veganpermanently 10-Sep-22 08:38 AM
no
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le_drig 10-Sep-22 08:41 AM
ok
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ibtisam.midlet 10-Sep-22 08:55 AM
@le_drig with theanine, it calms the mind, makes it less noisy, and gives you mental energy.
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le_drig 10-Sep-22 08:55 AM
Theanine weak
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ibtisam.midlet 10-Sep-22 08:57 AM
schisandra
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le_drig 10-Sep-22 08:57 AM
Its good
08:57
For glymphatic system too
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ibtisam.midlet
@le_drig with theanine, it calms the mind, makes it less noisy, and gives you mental energy.
veganpermanently 10-Sep-22 09:26 AM
have u megadosed theanine
09:26
like 1g+
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family guy 10-Sep-22 09:40 AM
I have
09:40
I needed that much for anxiolytic effects when i had bad days
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ibtisam.midlet 10-Sep-22 09:44 AM
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family guy 10-Sep-22 09:46 AM
@ibtisam.midlet thats a really nice sounding board, what is it?
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ibtisam.midlet
Click to see attachment 🖼️
veganpermanently 10-Sep-22 09:48 AM
motherfucker
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family guy
I have
veganpermanently 10-Sep-22 09:49 AM
what doses? was it effective? how did it feel? did it affect cognition?
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family guy
@ibtisam.midlet thats a really nice sounding board, what is it?
veganpermanently 10-Sep-22 09:49 AM
I'm wondering as well. looks pretty too
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family guy
@ibtisam.midlet thats a really nice sounding board, what is it?
ibtisam.midlet 10-Sep-22 09:50 AM
Its custom made , and the sound is from speaker afaik
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veganpermanently
have u megadosed theanine
ibtisam.midlet 10-Sep-22 09:51 AM
Yep
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ibtisam.midlet
Click to see attachment 🖼️
ibtisam.midlet 10-Sep-22 09:51 AM
Reverse search that photo
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veganpermanently
like 1g+
ibtisam.midlet 10-Sep-22 09:52 AM
10g
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ibtisam.midlet
10g
veganpermanently 10-Sep-22 09:53 AM
how was it
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family guy
@ibtisam.midlet thats a really nice sounding board, what is it?
ibtisam.midlet 10-Sep-22 09:54 AM
Its keyboard sound look https://youtu.be/oOdfefV2R1I
NoThisIsJohn
Everything you need to know to get from 0 to 200 WPM!
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veganpermanently
how was it
ibtisam.midlet 10-Sep-22 09:55 AM
Mindfulness, alertness, muscle relaxants, happiness
10:00
https://www.reddit.com/r/ErgoMechKeyboards/comments/s9hlju/thumbs_up_44_key_keyboard/
r/ErgoMechKeyboards - Thumbs Up! 44 Key Keyboard
149 votes and 24 comments so far on Reddit
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21-Jan-22 10:37 AM
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Sexy Seojin
🐤
ibtisam.midlet 10-Sep-22 10:05 AM
🐤 1
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Mabus Tiefsee 10-Sep-22 10:10 AM
is today everybody drawing?
Image attachment
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ibtisam.midlet 10-Sep-22 10:14 AM
better then mediation ☝️
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🌈Ritalin&Rainbows🌈 10-Sep-22 10:14 AM
Hey guys
10:14
I'm on alot of dxm
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ibtisam.midlet 10-Sep-22 10:14 AM
improve spatial memory and use both sides of brain
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🌈Ritalin&Rainbows🌈 10-Sep-22 10:14 AM
Just need people to talk to
10:15
How is everyone
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🌈Ritalin&Rainbows🌈
How is everyone
ibtisam.midlet 10-Sep-22 10:15 AM
Some are manic some are wonder
10:17
Do you feel like you want to just engage in simple conversion , not analytical one
10:17
I got that on dextrovers before
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Sexy Seojin 10-Sep-22 10:18 AM
Haaaaaaammmmmm
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MEE6 BOT 10-Sep-22 10:18 AM
@Sexy Seojin, you have advanced to lvl 2 respect++ emoji_51
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Sexy Seojin 10-Sep-22 10:18 AM
🥱🥱🥱🥱
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ibtisam.midlet 10-Sep-22 10:18 AM
KaBoooom
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ibtisam.midlet
better then mediation ☝️
Mabus Tiefsee 10-Sep-22 10:27 AM
it is a different kind of meditation. But the most fun meditation is always followed with "magic" rituals
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MEE6 BOT 10-Sep-22 10:27 AM
@Mabus Tiefsee, you have advanced to lvl 8 respect++ emoji_51
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🌈Ritalin&Rainbows🌈
How is everyone
Mabus Tiefsee 10-Sep-22 10:29 AM
At a village festival.... showing presence for my duck project.. The difficult part, making it look like the hybridisationsni start next year are "natural" and just an accident.
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veganpermanently
what doses? was it effective? how did it feel? did it affect cognition?
family guy 10-Sep-22 11:00 AM
Like 1200mg. Helped calm me down and feel clearer. But its subtle, theres probably more powerful noots.
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le_drig
+ Shiljait (lowers serotonin)
𝔘𝔵𝔨ü𝔩𝔩 10-Sep-22 01:04 PM
source?
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le_drig 10-Sep-22 02:25 PM
@𝔘𝔵𝔨ü𝔩𝔩 dont have rn
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MEE6 BOT 10-Sep-22 02:25 PM
@le_drig, you have advanced to lvl 3 respect++ emoji_51
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le_drig 10-Sep-22 02:25 PM
Mechanical KEyboards are best @ibtisam.midlet
14:25
I have ducky one 2 sf red switches
14:26
@𝔘𝔵𝔨ü𝔩𝔩 im about to fix pssd
👍 1
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Leonardo Ruilova BOT 10-Sep-22 02:58 PM
I am a 40 year old South American (Chile) guy with a physical disability linked to chronic pain, here the health system does not give me a diagnostic, not even a treatment, solution of disability certificationI started using relaxation techniques in 2009, during 2014 I used 3 techniquesI started as a Qi Gong student during 2015When I have economical stability, the pain is a lot lessNo matter pills, complementary medicine or "snake oil", my pain evolves with my socio economic stageAt least I validate with my experience the useless condition of complementary and alopathic medicine (@Mabus Tiefsee)
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Mabus Tiefsee
it is a different kind of meditation. But the most fun meditation is always followed with "magic" rituals (@ibtisam.midlet)
10-Sep-22 10:27 AM
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le_drig
@𝔘𝔵𝔨ü𝔩𝔩 dont have rn
𝔘𝔵𝔨ü𝔩𝔩 10-Sep-22 02:58 PM
found it: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1992;volume=24;issue=1;spage=12;epage=17;aulast=Jaiswal;type=0
Effects of Shilajit on memory, anxiety and brain monoamines in rats...
An official publication of the Indian Pharmacological Society
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ibtisam.midlet 10-Sep-22 11:23 PM
I made an explanation on the deference between high impect vs low impact ampa pam
23:23
Normal situation: Receptors x10 ©@(75%)= ==> ©@(75%)= ==> ©@(75%)= ==> ©@(75%)= ©@(75%)= ©@(75%)= ©@(75%)= = = =
23:24
© = glutamate (efficacy=75%=agonist)
23:24
Situation with low impact ampa pam: ©@(75%)= ==> ©@(75%)= ==> ©@(75%)= ==> ©@(75%)= ©@(75%)= ©@(75%)= ©@(75%)= ®@(30%)= ®@(30%)= ®@(30%)=
23:25
® = low impact ampa pam (efficacy=30%=partial agonist on allostric sites)
23:25
The ampa Pam accupy the remaining binding sites (uncompetitive)
23:25
Situation with low impact ampa pam used in high doses: ®@(30%)= ==> ®@(30%)= ==> ®@(30%)= ==> ®@(30%)= ®@(30%)= ®@(30%)= ®@(30%)= ®@(30%)= ®@(30%)= ®@(30%)=
23:26
This cause dose dependent curve mentioned here"AMPAR activators—including AMPAR agonists and AMPAR potentiators—have some limitations such as insufficient potency, the risk of seizure, and bell-shaped dose–response" https://www.sciencedirect.com/science/article/pii/S009130572100188XX
23:26
low dosed (75x7)+(30x3)=615 activity High dosed (30x10)=300 activity (less)
23:26
If you used high impact (efficacy 60%+) then the synpatic activity resulted will accessed ~700 causing toxicity https://www.nature.com/articles/srep15453 What ya think
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute f...
Scientific Reports - Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments
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𝔘𝔵𝔨ü𝔩𝔩
found it: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1992;volume=24;issue=1;spage=12;epage=17;aulast=Jaiswal;type=0
le_drig 11-Sep-22 01:02 AM
exactly
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le_drig 11-Sep-22 06:23 AM
@ibtisam.midlet you take venlafaxine?
06:27
https://www.longecity.org/forum/topic/54028-treating-anxiety-safely-effectively/
TREATING ANXIETY SAFELY & EFFECTIVELY - Mental Health
Page 1 of 27 - TREATING ANXIETY SAFELY & EFFECTIVELY - posted in Mental Health: Since treating ANXIETY and/or BENZODIAZEPINE WITHDRAWAL seems to be a reoccurring topic I thought it best to post this as a new topic, such that it can be linked to from other threads or read in its own right.Because this is going to comprise quite a bit of informati...
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lmao
06:30
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le_drig
@ibtisam.midlet you take venlafaxine?
ibtisam.midlet 11-Sep-22 06:31 AM
Anafranil, between vena is stronger, but rough withdrawal
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le_drig 11-Sep-22 06:31 AM
You take it daily?
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ibtisam.midlet 11-Sep-22 06:31 AM
Ofc
06:32
Esci is weaker 3 times then anaf
06:32
Vena stronger 30% then anaf
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le_drig 11-Sep-22 06:33 AM
Ok
06:33
what do you take it for
06:33
anxiety?
06:33
why no psychedelics?
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ibtisam.midlet 11-Sep-22 06:34 AM
inhibit narcissistic behaviors (edited)
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veganpermanently 11-Sep-22 06:34 AM
I need anxiogenics
06:34
I've become too relaxed
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le_drig 11-Sep-22 06:34 AM
Ok
06:34
MEth
06:34
Jk
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ibtisam.midlet 11-Sep-22 06:36 AM
Do anyone know why girls do dark makeup??
06:37
Like https://discord.com/channels/1001420842179239936/1001422037539106926/1017892893182136430
06:37
vegan's shared
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ibtisam.midlet
Do anyone know why girls do dark makeup??
veganpermanently 11-Sep-22 07:25 AM
one word
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Drafter 11-Sep-22 09:43 AM
I bought some vitamin d3 powder and the packaging says 100 000iu per g but the ingredients say 100% vitamin d. The thing is, if it's really pure vitamin d3 then it's more like 10 000 000(educated guess) iu per gram
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MEE6 BOT 11-Sep-22 09:43 AM
@Drafter, you have advanced to lvl 1 respect++ emoji_51
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Drafter
I bought some vitamin d3 powder and the packaging says 100 000iu per g but the ingredients say 100% vitamin d. The thing is, if it's really pure vitamin d3 then it's more like 10 000 000(educated guess) iu per gram
ibtisam.midlet 11-Sep-22 10:40 AM
1 g vitamin d3 = 40,000,000 IU https://mypharmatools.com/othertools/iu
International units converter (between IU and g/mg/mcg) — MY PHARMA...
MY PHARMA TOOLS
10:41
100% for promotion
10:42
and as a 100% of vit d3 pure no other active substances..
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ibtisam.midlet
100% for promotion
Drafter 11-Sep-22 02:09 PM
hopefully. I don't think is 100% vitD. I already took 100mg before I realized 100kiu per fram was a bit low for pure vitD. I was just following the instructions
14:10
vit d is not water soluble but it says water soluble on the box so I'm going to try and mix it with water to be sure (edited)
14:11
I should be able to sue the them for this. Imagine some retard uses this and then one day buys actual pure vitD and keeps taking the same dose (edited)
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Auwii 11-Sep-22 04:05 PM
They could kill someone if it was pure, so surely they use fillers
16:06
But can't be sure, when they are contradicting with reality (edited)
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Leonardo Ruilova BOT 11-Sep-22 05:44 PM
There is no enough technology to measure effects of meds inside the brainAny kind of neuro imaging is closed source, so its data is not verifiable, except when we use open source electro encephalographyAny kind of meds require a proper (open source) measure of its effects, as it is possible in diabetes or insuline resistanceBy the way, the proper sciences to modify and measure human behavior are genetics and behavioral psychologyThese sciences implies the will of the patientThere is no enough science to make weak will, because there exists counter measures against that, even in the hypocratic ethics (@le_drig)
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le_drig#7630
what do you take it for
11-Sep-22 06:33 AM
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Netizenne 11-Sep-22 09:18 PM
Are kava and lions mane okay together
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Netizenne
Are kava and lions mane okay together
ibtisam.midlet 11-Sep-22 09:43 PM
Yep
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ibtisam.midlet
If you used high impact (efficacy 60%+) then the synpatic activity resulted will accessed ~700 causing toxicity https://www.nature.com/articles/srep15453 What ya think
ibtisam.midlet 11-Sep-22 10:09 PM
To solve this you need to upregulate the number of receptors instead of aggressively using the same amount. Edit: AMPA receptors are ligand-gated ion channels (edited)
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ExileMage 12-Sep-22 05:54 AM
Anyone have access to this? Sci-Hub doesn't have access to it and my friend's college doesn't subscribe to this Journal either https://royalsocietypublishing.org/doi/abs/10.1098/rstb.2021.0050
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ibtisam.midlet 12-Sep-22 06:37 AM
https://changlab.yale.edu/sites/default/files/files/Putnam_and_Chang_2022b_PTRB.pdf
06:38
@ExileMage
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Adea Osmani 12-Sep-22 07:16 AM
Open DM🍑
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ibtisam.midlet
inhibit narcissistic behaviors (edited)
🌈Ritalin&Rainbows🌈 12-Sep-22 07:27 AM
i wasn't aware there was anything that could even potentially do this
07:27
That's very interesting
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ibtisam.midlet
https://changlab.yale.edu/sites/default/files/files/Putnam_and_Chang_2022b_PTRB.pdf
ExileMage 12-Sep-22 07:27 AM
Cum
07:27
Thank u
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le_drig
Click to see attachment 🖼️
Sexy Seojin 12-Sep-22 11:48 AM
Propranolol..?
11:48
It just beta blocker
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le_drig 12-Sep-22 01:12 PM
it also does something to anxiety
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Leonardo Ruilova BOT 12-Sep-22 02:24 PM
There is just correlation between meds and behavior, or meds and extracranial measurement of hormonesThere is no enough technology to measure intracranial and in vivo hormone levelsAny closed source neuro imaging method just measures brain structures, not hormonesAny DNA test gives correlation between different aspects, but what about epigenetics? (@🌈Ritalin&Rainbows🌈)
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JamieAnne
i wasn&#x27;t aware there was anything that could even potentially do this (@ibtisam.midlet)
12-Sep-22 07:27 AM
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sono 12-Sep-22 03:42 PM
Got a random question for you experts. Dumb question i guess. if i put iodine on the mole on my nose, will it eventually dry up and come off?
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sono
Got a random question for you experts. Dumb question i guess. if i put iodine on the mole on my nose, will it eventually dry up and come off?
ibtisam.midlet 12-Sep-22 05:28 PM
Use 1% iodine like Betadine
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Evelien 13-Sep-22 06:48 PM
How to get more REM-sleep? Deep sleep, latency etc... all seems good. Total sleep is not great, but not too bad, but it seems most nights I don't get any REM until right before I get up, so nothing the first +- 4 hours.... :/
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Evelien
How to get more REM-sleep? Deep sleep, latency etc... all seems good. Total sleep is not great, but not too bad, but it seems most nights I don't get any REM until right before I get up, so nothing the first +- 4 hours.... :/
ibtisam.midlet 13-Sep-22 10:48 PM
The brain does most of its repairing during Stage 3 non-REM
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ibtisam.midlet 13-Sep-22 11:01 PM
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Evelien
How to get more REM-sleep? Deep sleep, latency etc... all seems good. Total sleep is not great, but not too bad, but it seems most nights I don't get any REM until right before I get up, so nothing the first +- 4 hours.... :/
Yana 14-Sep-22 05:47 AM
Same (edited)
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machineyadav 14-Sep-22 05:48 AM
I like deep sleep more since it's associated with GH release
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Yana
Same (edited)
veganpermanently 14-Sep-22 05:48 AM
lel that's the healthy sleep architecture
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machineyadav 14-Sep-22 05:49 AM
I also read REM sleep deprivation can literally kill you so its sussy
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veganpermanently 14-Sep-22 05:49 AM
the body first knocks off the deep sleep or at least tries to
05:50
then after 5 hours of the deep to semi shallow sleep variation it enters the first REM cycle which lasts a few minutes then back to deep sleep for 45 mins exactly
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Yana 14-Sep-22 05:50 AM
I don't know how to separate REM sleep and mere dream recall because I'm going off the latter
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veganpermanently 14-Sep-22 05:50 AM
then the REM lengthens and the cycle repeats
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Yana 14-Sep-22 05:50 AM
And the fact I almost never wake up at night
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veganpermanently 14-Sep-22 05:51 AM
after 12 hours your REM cycle can be up to 20 mins
05:52
had much dreams past few days
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veganpermanently
lel that's the healthy sleep architecture
Yana 14-Sep-22 05:52 AM
Wdym? Shouldn't you get up right after a long final REM stage
05:52
I swear I just magically become half-conscious and fade into existence
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Yana
Wdym? Shouldn't you get up right after a long final REM stage
veganpermanently 14-Sep-22 05:52 AM
yes read what that person wrote
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Yana 14-Sep-22 05:52 AM
Oops I read it as REM only the first 4 hours
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veganpermanently 14-Sep-22 05:53 AM
galantamine is good for REM
05:53
I invented a device that will cause lucid dreams but I need a source of galantamine
05:54
it will supply galantamine directly to the brain and flash red light when it senses motion of the eyes
05:55
this will cause the whole dreamscape to light up red which will signal lucidity to the dreamer when pretrained via reality checks with randomized red light in the living room
05:56
I love lucid dreams but from my experience it takes too much effort. this would take almost none
05:57
u only have to put the mask on your face when you wake up and continue sleeping
05:59
I was successful with nearly all methods of lucid dreaming... wake induced, mnemonic, reality checks, dream journaling, etc., but all of it takes too much time.
06:00
reality checks are cool but redundant due to the fact that you have to find cues that happen often in the dream. It's easier to CAUSE the cue with the red light
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Yana 14-Sep-22 06:11 AM
Maybe it's galantamine time 🤷‍♂️ it feels odd changing the sleep architecture to your will instead of letting it remain natural but we shall see
06:12
Caffeine use delays/decreases REM anyways (edited)
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Yana
Maybe it's galantamine time 🤷‍♂️ it feels odd changing the sleep architecture to your will instead of letting it remain natural but we shall see
veganpermanently 14-Sep-22 06:41 AM
I used to think like this about various stuff from hormones to sleep and mood. Nowadays I can see how that's fallacious bcs we modulate this stuff whether we want it or not, in one direction or the other. Might as well give our best to make it all optimal (edited)
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veganpermanently
I used to think like this about various stuff from hormones to sleep and mood. Nowadays I can see how that's fallacious bcs we modulate this stuff whether we want it or not, in one direction or the other. Might as well give our best to make it all optimal (edited)
Yana 14-Sep-22 06:46 AM
Agreed but who's to say it's "optimal"
06:46
For hormones etc. I agree but sleep feels a bit different
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Yana
Agreed but who's to say it's "optimal"
veganpermanently 14-Sep-22 06:47 AM
increase in REM sleep without disruption of sleep architecture is def desired
06:49
there are studies showing it improves emotional control, memory, etc.
06:50
we can easily increase slow wave sleep without disrupting REM as well, with melatoninergic modulation
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veganpermanently
increase in REM sleep without disruption of sleep architecture is def desired
Yana 14-Sep-22 06:58 AM
Is there not a cost in the other stages if you want to increase REM?
06:58
Dream recall being something different
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Yana
Is there not a cost in the other stages if you want to increase REM?
veganpermanently 14-Sep-22 07:01 AM
not necessarily. you can increase the amplitude or duration of sleep without changing the sleep architecture
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veganpermanently
not necessarily. you can increase the amplitude or duration of sleep without changing the sleep architecture
Yana 14-Sep-22 07:02 AM
How does this look on a hypnogram
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Free Will I Am 14-Sep-22 07:02 AM
Polyphasic sleeping increased my Lucid Dreaming without effort. The long term effects of that haven't been well tested as people on the old Nootopics like to keep reminding me
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Yana
How does this look on a hypnogram
veganpermanently 14-Sep-22 07:02 AM
I don't know what that is to be sincere
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Free Will I Am
Polyphasic sleeping increased my Lucid Dreaming without effort. The long term effects of that haven't been well tested as people on the old Nootopics like to keep reminding me
veganpermanently 14-Sep-22 07:02 AM
that's the most intensive effort for me
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Free Will I Am 14-Sep-22 07:02 AM
It was
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veganpermanently 14-Sep-22 07:03 AM
using stims makes polyphasic sleep useless and hard to do
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Free Will I Am 14-Sep-22 07:03 AM
Not the actual sleeping itself
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veganpermanently
using stims makes polyphasic sleep useless and hard to do
Free Will I Am 14-Sep-22 07:03 AM
Oh, I never used stims
07:03
Your circadian will never fix if you use stims on poly
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veganpermanently 14-Sep-22 07:03 AM
I do caffeine, nicotine, modafinil
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Free Will I Am 14-Sep-22 07:03 AM
You might be able to get away with a morning dose on something like segmented
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veganpermanently 14-Sep-22 07:04 AM
my circadian amplitude is very high, I like to keep it that way
07:04
no 2am energy dip
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Free Will I Am 14-Sep-22 07:04 AM
Yeah no doubt
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veganpermanently 14-Sep-22 07:05 AM
slow wave sleep is good due to agomelatine
07:05
REM is amiss a bit
07:05
which is why I want galantamine but it's expensive
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Free Will I Am 14-Sep-22 07:06 AM
How expensive?
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veganpermanently 14-Sep-22 07:06 AM
best quote I got was 50000 USD for a kg
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MEE6 BOT 14-Sep-22 07:06 AM
@Free Will I Am, you have advanced to lvl 9 respect++ emoji_51
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Free Will I Am 14-Sep-22 07:06 AM
Oh
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veganpermanently
I don't know what that is to be sincere
Yana 14-Sep-22 07:06 AM
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veganpermanently
best quote I got was 50000 USD for a kg
Free Will I Am 14-Sep-22 07:06 AM
Wait... 50k?!
07:06
For 1k?
07:06
1kg*
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veganpermanently 14-Sep-22 07:06 AM
yes
07:06
it is impossible to synthesize it
07:07
it's extracted from a plant which produces very small quantities and the extraction itself is expensive because it must be very pure due to the fact that the plant contains many toxic alkaloids as well
💀 2
07:08
it's a hard problem
07:08
we need to modify a yeast to produce it that would be best bet I think
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Free Will I Am 14-Sep-22 07:09 AM
I guess that would be the first thing you would try to do if you could get your hands on some? That's if you need the substance to produce it
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Free Will I Am
I guess that would be the first thing you would try to do if you could get your hands on some? That's if you need the substance to produce it
veganpermanently 14-Sep-22 07:10 AM
I want to make a prodrug from it to make direct brain delivery possible.
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veganpermanently
I want to make a prodrug from it to make direct brain delivery possible.
Yana 14-Sep-22 07:10 AM
Galantamine XR?
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MEE6 BOT 14-Sep-22 07:10 AM
@Yana, you have advanced to lvl 7 respect++ emoji_51
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veganpermanently 14-Sep-22 07:10 AM
GI exposure is a problem obviously
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Yana 14-Sep-22 07:10 AM
Delayed release
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veganpermanently 14-Sep-22 07:10 AM
no
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Yana 14-Sep-22 07:11 AM
Or is that not useful
07:11
Because there's the method where you wake up after 4 hours and take galantamine then go back to sleep (edited)
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Yana
Because there's the method where you wake up after 4 hours and take galantamine then go back to sleep (edited)
veganpermanently 14-Sep-22 07:19 AM
yeah that's the reasoning
07:20
but I want to increase CNS exposure to allow freedom of dosing
07:20
40 mg would obviously be more effective than 4 but 40 would surely give you diarrhea
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veganpermanently 14-Sep-22 11:40 AM
https://www.reddit.com/r/Nootropics/comments/xdp3ug/fasoracetam_highly_addictive/
r/Nootropics - Fasoracetam HIGHLY ADDICTIVE
5 votes and 5 comments so far on Reddit
11:41
emoji_1
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veganpermanently
40 mg would obviously be more effective than 4 but 40 would surely give you diarrhea
Pax1l 14-Sep-22 07:30 PM
Diarrhea you say 😳
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Pax1l 14-Sep-22 07:59 PM
Just had about 100mcg of igf2 intranasal. It's exceptionally powerful in raising mood. (edited)
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veganpermanently
we need to modify a yeast to produce it that would be best bet I think
Pax1l 14-Sep-22 08:06 PM
I think at that point its beyond feasibility. While i wouldve loved getting a synth of the galantamine curcumin hybrid i think it mat be worth looking at something like a multi target drug ligand if we wanted something exciting
20:07
There was a tacrine deferiprone mtdl which has improved toxicity profile as well as enhanced binding to acetycholinterase
20:09
It also has iron chelating properties so thats an extra win. Otherwise I dont believe synthing small molecule drugs are as worth it compared to the affordability, and speed that peptide synths can reach
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ibtisam.midlet
I made an explanation on the deference between high impect vs low impact ampa pam
Pax1l 14-Sep-22 08:17 PM
Working on a ampa glu1, nr2a, nr2b pam. Just sent the funding to the lab tonight. Should be very fun!
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ibtisam.midlet 15-Sep-22 10:02 AM
this life is so easy
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ibtisam.midlet 15-Sep-22 10:35 AM
kleptomania being one of D3 hyperactivity subjective effect mehhh
10:35
(a recurrent urge to steal, typically without regard for need or profit)
10:36
https://en.wikipedia.org/wiki/Impulse-control_disorder
Impulse-control disorder
Impulse-control disorder (ICD) is a class of psychiatric disorders characterized by impulsivity – failure to resist a temptation, an urge, or an impulse; or having the inability to not speak on a thought. Many psychiatric disorders feature impulsivity, including substance-related disorders, behavioral addictions, attention deficit hyperactivity ...
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Damianze 15-Sep-22 02:46 PM
For a genetically modified creature, if it only passes down half of its DNA to its offsprings when it reproduce, is it possible that one of its offspring might not inherited any of the modified genes?
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Damianze
For a genetically modified creature, if it only passes down half of its DNA to its offsprings when it reproduce, is it possible that one of its offspring might not inherited any of the modified genes?
ibtisam.midlet 15-Sep-22 04:47 PM
The offspring pass one half of its DNA, which can be the none modified part He will not express the gene if the other parent downed part is dominant
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ibtisam.midlet
The offspring pass one half of its DNA, which can be the none modified part He will not express the gene if the other parent downed part is dominant
Damianze 15-Sep-22 04:49 PM
Is it depends on which chromosome it is located? Besides the sex chromosome Y and X, which of the chromosomes are more likely to be passed down, and which of the chromosomes are more prone to get shuffled off when a germline cell is matured? Is the chance entirely random?
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Damianze
Is it depends on which chromosome it is located? Besides the sex chromosome Y and X, which of the chromosomes are more likely to be passed down, and which of the chromosomes are more prone to get shuffled off when a germline cell is matured? Is the chance entirely random?
ibtisam.midlet 15-Sep-22 04:52 PM
The expression is not gambling, but the pass down is
16:55
You can read this https://discord.com/channels/1001420842179239936/1006326720573481091/1006326726944632882
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ibtisam.midlet
The expression is not gambling, but the pass down is
Damianze 15-Sep-22 05:57 PM
So the dominant/recessive expression is usually fixed, with some genes being more dominant and some being recessive, but the chance of which genes will get pass down, which will be lost forever is all random?
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17:59
Like just because a gene is more dominant, doesn't mean that it will be the one that will be passed down during genetic shuffling in germline?
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ibtisam.midlet 16-Sep-22 04:18 AM
Image attachment
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ibtisam.midlet 16-Sep-22 04:28 AM
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veganpermanently 16-Sep-22 09:00 AM
how do we biohack lung capacity
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ibtisam.midlet 16-Sep-22 10:31 AM
https://www.nature.com/articles/s41422-020-0369-7#:~:text=Alveolar%20regeneration%20after%20an%20acute,new%20alveoli%20after%20lung%20injury.
Pulmonary alveolar regeneration in adult COVID-19 patients
Cell Research - Pulmonary alveolar regeneration in adult COVID-19 patients
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10:32
https://en.wikipedia.org/wiki/Pulmonary_alveolus
Pulmonary alveolus
A pulmonary alveolus (plural: alveoli, from Latin alveolus, "little cavity"), also known as an air sac or air space, is one of millions of hollow, distensible cup-shaped cavities in the lungs where oxygen is exchanged for carbon dioxide. Alveoli make up the functional tissue of the mammalian lungs known as the lung parenchyma, which takes up 90 ...
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10:38
@veganpermanently
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veganpermanently 16-Sep-22 10:39 AM
@ibtisam.midlet I suspect HIF1a/VEGF cascade is a target?
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Damianze 16-Sep-22 12:55 PM
I have read that chromosomes in germline cells will "cross-over" to exchange genes with each other, does this happen only after the germline cell has half of its chromosomes separated from diploid to haploid? Or it already happened in the progenitor cells with a full set of DNA when there are still 46 chromosomes in it?
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veganpermanently
@ibtisam.midlet I suspect HIF1a/VEGF cascade is a target?
ibtisam.midlet 16-Sep-22 10:54 PM
it protect from injury, but not induce regeneration demonstrate that mechanical-tension-induced YAP activation in alveolar stem cells plays a major role in promoting post-PNX alveolar regeneration https://pubmed.ncbi.nlm.nih.gov/27498861/
MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pu...
The pulmonary alveolar epithelium undergoes extensive regeneration in response to lung injuries, including lung resection. In recent years, our understanding of cell lineage relationships in the pulmonary alveolar epithelium has improved significantly. However, the molecular and cellular mechanisms …
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22:54
we showed that EC-niche-generated S1P is an important signal to activate AT2 cell YAP through S1PR2. https://www.cell.com/cell-reports/pdfExtended/S2211-1247(20)30809-3
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ibtisam.midlet 16-Sep-22 11:09 PM
AT2 cells who do regeneration, but the primary way to activate them hard to find
23:10
there multiple co-factors found but they are not important much, the regeneration is already happening after covid what will sure fix that is inducing it more, otherwise co-factors don't play a bottleneck in normal situation
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ibtisam.midlet 17-Sep-22 02:25 AM
https://www.jneurosci.org/content/jneuro/19/21/9550.full.pdf
02:25
Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli
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ibtisam.midlet
Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli
veganpermanently 17-Sep-22 02:36 AM
been wanting to find an available d4 agonist for a while. it appears it is prosexual, stimulant and doesn't downregulate at least not as quickly as other DA receptors
02:37
https://pubmed.ncbi.nlm.nih.gov/19020411/
Selective dopamine D4 receptor agonist (A-412997) improves cognitiv...
Current therapies for attention deficit hyperactivity disorder comprise psychostimulants, which block the dopamine transporter and/or stimulate the release of dopamine, leading to a global elevation in extrasynaptic dopamine. These drugs are, however, associated with a series of unwanted side effect …
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veganpermanently
been wanting to find an available d4 agonist for a while. it appears it is prosexual, stimulant and doesn't downregulate at least not as quickly as other DA receptors
ibtisam.midlet 17-Sep-22 02:41 AM
Gotta get another type of intelligence 975869691522326638
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erin 17-Sep-22 06:12 AM
based
06:12
i walk in and get hit with a nerd linking a ton of papers
06:12
this is what i like to see
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a r c t !^ 17-Sep-22 06:21 AM
feddy
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erin
i walk in and get hit with a nerd linking a ton of papers
veganpermanently 17-Sep-22 07:14 AM
not the n word
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erin 17-Sep-22 07:15 AM
<3
07:15
nerds are beautiful
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erin
nerds are beautiful
veganpermanently 17-Sep-22 07:15 AM
no such thing as drug nerd. we're geeks
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erin 17-Sep-22 07:16 AM
lies
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erin
lies
veganpermanently 17-Sep-22 07:16 AM
Image attachment
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erin 17-Sep-22 07:16 AM
im aware of the distinction
07:17
geeks typically have more social skills than nerds
07:17
its certainly possible to have a special interest in neurochemistry and have shit social skills lol
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erin
its certainly possible to have a special interest in neurochemistry and have shit social skills lol
veganpermanently 17-Sep-22 07:18 AM
do u know of the slang 'being geek'd out'
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erin 17-Sep-22 07:18 AM
thats when you do a lot of meth and read papers for 12 hours straight right
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veganpermanently 17-Sep-22 07:18 AM
indeed
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erin 17-Sep-22 07:19 AM
anyway heres my contribution
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MEE6 BOT 17-Sep-22 07:19 AM
@erin, you have advanced to lvl 1 respect++ emoji_51
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erin 17-Sep-22 07:19 AM
https://catgirl.online/2020/05/05/comt-mutations-and-stimulants.html
I have ADHD that I've been treated for off and on throughout my life. Recently, I sought psychostimulant treatment as I was having trouble being interested in projects at work that were necessary and prolonged. I had pharmacogenetic testing performed several years ago, and at that time found it odd that it had remarked on increased stimulant sid...
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veganpermanently 17-Sep-22 07:20 AM
@brothermanbill can u verify your identity
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veganpermanently
do u know of the slang 'being geek'd out'
brothermanbill 17-Sep-22 07:20 AM
When you take desoxyparaxanthine https://en.m.wikipedia.org/wiki/Desoxypipradrol
Desoxypipradrol
Desoxypipradrol, also known as 2-⁠diphenylmethylpiperidine (2-DPMP), is a drug developed by Ciba in the 1950s which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI).
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veganpermanently
@brothermanbill can u verify your identity
brothermanbill 17-Sep-22 07:20 AM
Geek
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erin 17-Sep-22 07:21 AM
i apologize for misattributing nerdiness to yall :P
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brothermanbill
When you take desoxyparaxanthine https://en.m.wikipedia.org/wiki/Desoxypipradrol
veganpermanently 17-Sep-22 07:21 AM
that does it
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erin 17-Sep-22 07:21 AM
perhaps i was projecting
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veganpermanently
Click to see attachment 🖼️
erin 17-Sep-22 07:28 AM
anyway according to this i def fall closer to nerd than geek; (nerd) ✅ computer programming? coding? why do they use different terms. ig im not so good at it that im senior but people have said im probably mid-level ✅ fantasy/sci-fi ✅ lean twd introverted ✅ once upon a time poor social skills but theyve improved (geek) ✅ nich interests (not expect status, but thats probably downplaying myself) ✅ TECHNO MUSIQUE i dont have such encyclopedic knowledge as for it to be impractical, at least not in computer shit tho, considering i turned it into a successful career in system operations also why is either mac or PC a distinguishing trait?? who made this? did normies make this? i run arch linux
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erin
anyway according to this i def fall closer to nerd than geek; (nerd) ✅ computer programming? coding? why do they use different terms. ig im not so good at it that im senior but people have said im probably mid-level ✅ fantasy/sci-fi ✅ lean twd introverted ✅ once upon a time poor social skills but theyve improved (geek) ✅ nich interests (not expect status, but thats probably downplaying myself) ✅ TECHNO MUSIQUE i dont have such encyclopedic knowledge as for it to be impractical, at least not in computer shit tho, considering i turned it into a successful career in system operations also why is either mac or PC a distinguishing trait?? who made this? did normies make this? i run arch linux
veganpermanently 17-Sep-22 07:31 AM
emoji_50
07:31
ur funny
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erin 17-Sep-22 07:33 AM
thanks greyscale guru elder person
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veganpermanently 17-Sep-22 07:34 AM
I'm not sure I fall into either category
07:34
I get geeky about biology that's about it
07:35
hate fiction
07:35
techno is okay
07:36
coding makes me dissociated for days can't do it
07:38
socially inept no but I don't socialize much bcs I find meetings with people I used to call my friends draining nowadays
07:38
it's not even like they're doing something wrong I just can't stand the pointlessness of the events
07:39
used to just hate small talk so I found ways to start meaningful conversations then realized I am hanging around with incompetent people
07:40
all of their deepest thoughts are so simple and redundant
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veganpermanently
Click to see attachment 🖼️
Yana 17-Sep-22 08:24 AM
Low T vs High IQ
08:25
& 'tism
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Yana
Low T vs High IQ
veganpermanently 17-Sep-22 08:26 AM
I'm both 983795135575883818
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erin 17-Sep-22 08:45 AM
yana has the right of it
08:45
normies are so very boring 😩
08:46
hate small talk myself
08:46
like, i have to explain to people that i will just never respond to any message that amounts to 'hi' or 'how are you'
08:46
im not trying to be rude it just doesnt catch my attn
08:46
also probably i dissociate a lot and dont want to think about how i emotionally am doing :)
08:48
i like chatting about feelings and stuff, but typically not with normie acquaintances who think its weird and uncomfortable to talk about deep psychological issues within the first 10 minutes of meeting
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erin
i like chatting about feelings and stuff, but typically not with normie acquaintances who think its weird and uncomfortable to talk about deep psychological issues within the first 10 minutes of meeting
veganpermanently 17-Sep-22 08:49 AM
same
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erin 17-Sep-22 08:50 AM
so like, yeah, i dont want to answer 'how are you' in that context because it takes a lot of brain power to phrase shit in a way thats acceptable to someone who doesnt actually want to put much effort into empathizing or introspection
08:50
and that feels invalidating and bad
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veganpermanently 17-Sep-22 08:50 AM
nah they just ask that shit to act polite and concerned
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MEE6 BOT 17-Sep-22 08:50 AM
@veganpermanently, you have advanced to lvl 14 respect++ emoji_51
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veganpermanently 17-Sep-22 08:50 AM
it's like microvirtuesignalling or smthng
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erin 17-Sep-22 08:50 AM
yeah thats the problem
08:51
they dont actually care and get all awkward when i tell them how im actually feeling
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veganpermanently 17-Sep-22 08:51 AM
r u sure u care? is a good comeback
08:52
if they say yes then you can unload a truckfull bcs they asked for it
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erin 17-Sep-22 08:52 AM
i once asked a clerk at the grocery why they want to know how im doing
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MEE6 BOT 17-Sep-22 08:52 AM
@erin, you have advanced to lvl 2 respect++ emoji_51
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erin 17-Sep-22 08:52 AM
peak autism moment
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erin
i once asked a clerk at the grocery why they want to know how im doing
veganpermanently 17-Sep-22 08:52 AM
r u the FBI
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erin 17-Sep-22 08:52 AM
lol
08:53
"what if i told you im not doing very well? do you really want to know that?"
08:53
"oh uh, i mean, maybe i could cheer you up" (edited)
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erin
"oh uh, i mean, maybe i could cheer you up" (edited)
veganpermanently 17-Sep-22 08:53 AM
this is when I request a 10K EUR loan
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erin 17-Sep-22 08:54 AM
anyway, looking at my blog reminded me i havent posted anything in nearly a year
08:55
tryna finish this draft on my iPhone review
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veganpermanently 17-Sep-22 08:55 AM
blogs are so 2000
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erin 17-Sep-22 08:55 AM
i switched at the start of the year and have been taking notes on the experience, being a lifelong android user
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veganpermanently 17-Sep-22 08:56 AM
is iPhone better
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erin 17-Sep-22 08:56 AM
i love blogs! love reading a 10k word deep dive on some shit
08:56
no
08:56
it is significantly worse if you value customization whatsoever
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erin
i love blogs! love reading a 10k word deep dive on some shit
veganpermanently 17-Sep-22 08:56 AM
I like studies more
08:56
if crafted well they don't spike my HPPD or ADHD
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erin 17-Sep-22 08:57 AM
and by customization, i mean "using any non-apple application ever"
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veganpermanently 17-Sep-22 08:57 AM
they have short paragraphs and lots of graphs
08:57
I love graphs
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erin 17-Sep-22 08:57 AM
in addition to like, OS customization
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erin
it is significantly worse if you value customization whatsoever
veganpermanently 17-Sep-22 08:57 AM
oh yeah
08:57
forgot about that
08:58
for a sec
08:58
a friend gave me an iPhone to use for a month
08:58
I had to literally google every stupid shit
08:58
nothing is intuitive
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erin 17-Sep-22 08:58 AM
this is my closing section
unfortunately, i found that i'm far too much of a "power user" to be able to live comfortably with an iPhone. beyond that though, i think the largest of my problems arose from being unwilling to fully convert and buy in to the ecosystem. i'm sure that if i'd used FaceTime and iMessage instead of Discord, Apple Music instead of Spotify, and iCloud for notes and photos, i'd have had no audio or synchronization issues. alas, i have no interest in undoing all of the work i'd done to separate myself from cloud services. the consequences of this are much harsher on iOS. these devices may be perfectly adequate for normies who have no issue with paying for all this and handing their most precious data over to a mega-corpation. in my case, i'd rather own my data and reap the benefits of that. the sandboxing is obnoxious, intrusive and insulting. frankly i was shocked that after years and years of iPhone development, it's still such a hinderance to third-party apps! i'm frankly dumbfounded over how Apple manages to get any Android converts whatsoever with such a model being so central to their offerings.
 (edited)
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veganpermanently
nothing is intuitive
erin 17-Sep-22 08:58 AM
yes!
08:58
i dont get it
08:59
i heard that its all so intuitive and "just works" from iphone users
08:59
its not true!
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veganpermanently 17-Sep-22 08:59 AM
it's just made to look cleaner
08:59
which is probably the best feature of Apple
09:02
now I started asking myself dumb questions like would I want to live in an Apple house and drive an Apple car
09:02
and the answer is obvious
09:02
the aesthetic works only for a phone ig
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erin 17-Sep-22 09:04 AM
i thought id adjust to a lot of the things but it just.. didnt happen
09:04
i think because its just not as polished
09:04
like heres something obnoxious:
gesture actions have significant calibration issues that i was never able to adapt to * swipe directionality has to be made with high precision. if an app requires a swipe up to perform some action, but also has left/right swiping actions, when swiping slightly diagonally, the left/right action will occur. * swipe length and acceleration detection is less sensitive the sense that you have to swipe further on the screen for actuation to occur. this isn't ameliorated by flicking. * swiping too close to the screen edges accidentally triggers OS-level functionality when you don't intend to
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veganpermanently
which is probably the best feature of Apple
erin 17-Sep-22 09:06 AM
yes
09:06
my smooth aesthetics-driven girl brain was not immune to the pull of its beauty
09:06
this is 100% the reason i decided to try an iPhone
09:07
and its utterly gorgeous
09:07
the tech itself though? terrible
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veganpermanently 17-Sep-22 09:07 AM
can u replace OS
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erin 17-Sep-22 09:07 AM
no
09:07
there are no working jailbreaks
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veganpermanently 17-Sep-22 09:07 AM
omagah
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erin 17-Sep-22 09:08 AM
there have never been any replacement OSes to begin with though
09:08
just roots
09:08
because iOS isnt open source
09:09
jailbreaking would overcome a LOT of my gripes
09:09
i wish i could do it
09:09
i detest the sandboxing
09:11
there were no working hacks for the later pixel series either though
09:11
the behemoths have their security on lock meow
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erin
the behemoths have their security on lock meow
veganpermanently 17-Sep-22 09:13 AM
maybe we can find copies of their cases and use other hackable hardware
09:13
and make an illegal cellphone company 😛
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erin 17-Sep-22 09:14 AM
cases?
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MEE6 BOT 17-Sep-22 09:14 AM
@erin, you have advanced to lvl 3 respect++ emoji_51
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erin
cases?
veganpermanently 17-Sep-22 09:24 AM
I see there are iPhone 14 clones out there
09:26
what is the prettiest iPhone
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veganpermanently
what is the prettiest iPhone
Yana 17-Sep-22 12:43 PM
4s
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Netizenne 17-Sep-22 04:58 PM
https://amp.theguardian.com/lifeandstyle/2021/may/26/hot-tub-health-kick-why-a-long-bath-is-almost-as-good-for-you-as-a-long-run Real???
Hot tub health kick: why a long bath is almost as good for you as a...
Researchers have discovered that prolonged immersion in a piping hot bath has many of the same medical benefits as aerobic exercise
16:58
I wanna get the cardiovascular of a triathalon
16:59
Lots of blood flow to the brain
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Cast 17-Sep-22 06:27 PM
Noots to lower empathy and raise cognitive empathy? (edited)
18:27
Im psychopath maxxing
18:29
Maybe agmantine and adderall
Avatar
Netizenne 17-Sep-22 06:37 PM
D-serine increases turnover of fear learning I think -both increasing extinction and learning (that’s how sirsad described it iirc). In other words it seems it makes fear learning more short term, less long lasting. It’s being studied for ptsd and such for this reason. Psychopaths are fast life history strategists (strong and well known association) -it could make sense if they fear things on a shorter time scale. Fast life history strategists are adapted for unstable environments where things are constantly changing and there’s no reason too look too far into the future. They are more selfish and higher in dark triad traits. Traditionally a key component of psychopaths was thought to be some sort of impairment with fear learning, athough some puzzling conflicting evidence both for and against this have come out. I haven’t looked into the exact details on this but maybe it’s partly that psychopaths have increased turnover of fear learning and a narrower timeframe of concern (like d-serine would produce). Everything I just said should be verified cause I am really just guessing Fear conditioning in psychopaths: Event-related potentials and peripheral measures https://www.sciencedirect.com/science/article/pii/S0301051112000336
In contrast with healthy controls, high psychopathic individuals appear deficient in the capacity to form appropriate associations between a cue and an aversive (Hare et al., 1978, Flor et al., 2002) or fear-evoking event (Patrick et al., 1994, Birbaumer et al., 2005)—despite intact cognitive processing of stimuli (Flor et al., 2002, Birbaumer et al., 2005, Kiehl, 2006). In healthy individuals, aversive or threatening cues result in the mobilization of defensive actions, which can be measured by fear-associated responses such as the startle reflex that increase during presentation of aversive stimuli (Davis, 1989, Lang et al., 1990, Patrick et al., 1996). In psychopathic individuals, who are theorized to lack the ability to anticipate and learn from punishment (Lykken, 1957, Hare and Quinn, 1971, Hare et al., 1978, Veit et al., 2002, Blair, 2004, Birbaumer et al., 2005, Mitchell et al., 2006), the fear-associated startle reflex has been found to be diminished or absent (Patrick et al., 1993, Levenston et al., 2000, Pastor et al., 2003, Benning et al., 2005). Startle potentiation in response to aversive events (Davis, 1992, Angrilli et al., 1996, Pissiota et al., 2003) as well as an anticipatory skin conductance response (Bechara et al., 1999) are known to be mediated by amygdalar connections, suggesting a deficit in the amygdala or affiliated structures in psychopathic individuals.
 (edited)
Fear conditioning in psychopaths: Event-related potentials and peri...
Aversive pavlovian delay conditioning was investigated in a sample of 11 criminal psychopaths as identified by using the Psychopathy Checklist-Revised…
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18:37
The volume of the nucleus accumbens was 13% smaller in psychopathy (p corrected for multiple comparisons <0.006).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603572/
D-serine down-regulated the BDNF signaling pathway in NAc during CSDS procedure. Furthermore, BDNF signaling inhibitor (K252a) enhanced the antidepressant effects of D-serine.
D-serine shrinks NAC????? What do the nac do? https://pubmed.ncbi.nlm.nih.gov/34654365/ (edited)
Atypical nucleus accumbens morphology in psychopathy: another limbi...
Psychopathy has been associated with increased putamen and striatum volumes. The nucleus accumbens –a key structure in reversal learning, less effective in psychopathy –has not yet received specific attention. Moreover, basal ganglia morphology ...
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D-Serine produces antidepressant-like effects in mice through suppr...
D-Serine exerts antidepressant-like effects in mice mediated through restraining the BDNF signaling pathway and regulating synaptic plasticity in NAc.
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Netizenne 17-Sep-22 07:01 PM
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Netizenne
https://amp.theguardian.com/lifeandstyle/2021/may/26/hot-tub-health-kick-why-a-long-bath-is-almost-as-good-for-you-as-a-long-run Real???
ibtisam.midlet 17-Sep-22 07:04 PM
That's a strong reward
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Netizenne
The volume of the nucleus accumbens was 13% smaller in psychopathy (p corrected for multiple comparisons <0.006).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603572/
D-serine down-regulated the BDNF signaling pathway in NAc during CSDS procedure. Furthermore, BDNF signaling inhibitor (K252a) enhanced the antidepressant effects of D-serine.
D-serine shrinks NAC????? What do the nac do? https://pubmed.ncbi.nlm.nih.gov/34654365/ (edited)
ibtisam.midlet 17-Sep-22 07:05 PM
D-serine +_+
19:06
How's this
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Netizenne 17-Sep-22 07:09 PM
They say people who’ve been through a lot of pain are the nicest
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ibtisam.midlet 17-Sep-22 07:09 PM
Oh yes agonisting nmda on reward system
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Netizenne
They say people who’ve been through a lot of pain are the nicest
ibtisam.midlet 17-Sep-22 07:10 PM
I think it depend
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Netizenne 17-Sep-22 07:10 PM
People who learn to forget everything become psychos and those who can’t become schizo maybe.
19:10
Wild guess
emoji_1 1
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Netizenne
People who learn to forget everything become psychos and those who can’t become schizo maybe.
ibtisam.midlet 17-Sep-22 07:12 PM
Cortisol enhance memory doing flashbulb memory for the trauma
19:13
When he found that this memory will goes with the person insane
19:13
Cortisol system seems to format it
19:15
Its some action done by PFC thinking I guess
19:17
Means PFC calculate if the memory is better to deleted or not, by expecting future , normally by downstream sinario cacadac
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Netizenne
People who learn to forget everything become psychos and those who can’t become schizo maybe.
Netizenne 17-Sep-22 07:20 PM
Remember to care Remember beware Remember the pains Of what possible nightmares (edited)
💟 1
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Netizenne
D-serine increases turnover of fear learning I think -both increasing extinction and learning (that’s how sirsad described it iirc). In other words it seems it makes fear learning more short term, less long lasting. It’s being studied for ptsd and such for this reason. Psychopaths are fast life history strategists (strong and well known association) -it could make sense if they fear things on a shorter time scale. Fast life history strategists are adapted for unstable environments where things are constantly changing and there’s no reason too look too far into the future. They are more selfish and higher in dark triad traits. Traditionally a key component of psychopaths was thought to be some sort of impairment with fear learning, athough some puzzling conflicting evidence both for and against this have come out. I haven’t looked into the exact details on this but maybe it’s partly that psychopaths have increased turnover of fear learning and a narrower timeframe of concern (like d-serine would produce). Everything I just said should be verified cause I am really just guessing Fear conditioning in psychopaths: Event-related potentials and peripheral measures https://www.sciencedirect.com/science/article/pii/S0301051112000336
In contrast with healthy controls, high psychopathic individuals appear deficient in the capacity to form appropriate associations between a cue and an aversive (Hare et al., 1978, Flor et al., 2002) or fear-evoking event (Patrick et al., 1994, Birbaumer et al., 2005)—despite intact cognitive processing of stimuli (Flor et al., 2002, Birbaumer et al., 2005, Kiehl, 2006). In healthy individuals, aversive or threatening cues result in the mobilization of defensive actions, which can be measured by fear-associated responses such as the startle reflex that increase during presentation of aversive stimuli (Davis, 1989, Lang et al., 1990, Patrick et al., 1996). In psychopathic individuals, who are theorized to lack the ability to anticipate and learn from punishment (Lykken, 1957, Hare and Quinn, 1971, Hare et al., 1978, Veit et al., 2002, Blair, 2004, Birbaumer et al., 2005, Mitchell et al., 2006), the fear-associated startle reflex has been found to be diminished or absent (Patrick et al., 1993, Levenston et al., 2000, Pastor et al., 2003, Benning et al., 2005). Startle potentiation in response to aversive events (Davis, 1992, Angrilli et al., 1996, Pissiota et al., 2003) as well as an anticipatory skin conductance response (Bechara et al., 1999) are known to be mediated by amygdalar connections, suggesting a deficit in the amygdala or affiliated structures in psychopathic individuals.
 (edited)
Cast 17-Sep-22 09:12 PM
I think i have maoa warrior genes that didnt activate since i had a good childhood
21:13
I have hella low serotonin sensitivty which is like indicative of these genes
21:13
I just need more trauma
21:14
I still have anxiety tho just to a lesser extent
21:15
In that its a different kind of anxiety
21:15
A sense of impending doom
21:15
But im not rlly anxious at a particular scenerio (edited)
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Cast
I think i have maoa warrior genes that didnt activate since i had a good childhood
veganpermanently 18-Sep-22 12:54 AM
jelly
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Cast
I just need more trauma
Netizenne 18-Sep-22 12:59 AM
I’ve heard people say that the military’s perfected using trauma to shape autists into functional human beings due to how long the tradition goes back lol (edited)
00:59
Idk if you really want it tho
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Netizenne
I’ve heard people say that the military’s perfected using trauma to shape autists into functional human beings due to how long the tradition goes back lol (edited)
veganpermanently 18-Sep-22 12:59 AM
u can do it yourself
00:59
self imposed trauma is gold
👀 1
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veganpermanently
self imposed trauma is gold
Netizenne 18-Sep-22 01:01 AM
I think I’ve had moments where I’ve metaphorically hit my head against wall mentally to get things to stick but only extremely rarely and in desperation (edited)
💟 1
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Netizenne
I think I’ve had moments where I’ve metaphorically hit my head against wall mentally to get things to stick but only extremely rarely and in desperation (edited)
veganpermanently 18-Sep-22 01:07 AM
people are into SM only in sexual environments because it's not socially accepted otherwise. When imposed on self there is nothing stopping us except death
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veganpermanently
people are into SM only in sexual environments because it's not socially accepted otherwise. When imposed on self there is nothing stopping us except death
Netizenne 18-Sep-22 01:13 AM
SM?
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Netizenne
SM?
veganpermanently 18-Sep-22 01:13 AM
sadism/mazochism
01:19
I have terrible bruxism headache today, only laughter relieves it
01:19
pls send me ur best memes
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Netizenne
I think I’ve had moments where I’ve metaphorically hit my head against wall mentally to get things to stick but only extremely rarely and in desperation (edited)
ibtisam.midlet 18-Sep-22 01:34 AM
Notice all big biologist in the community have behavior like this especially in childhood (edited)
01:35
We are not typical
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ibtisam.midlet 18-Sep-22 07:23 AM
found out that biohacking girls dominant longevity groups in facebook
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ibtisam.midlet
found out that biohacking girls dominant longevity groups in facebook
Cast 18-Sep-22 07:57 AM
Why u so downbad
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MEE6 BOT 18-Sep-22 07:57 AM
@Cast, you have advanced to lvl 1 respect++ emoji_51
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ibtisam.midlet 18-Sep-22 08:20 AM
To what exactly
08:22
I'm feminine addict
08:22
wanna be girl, feel I'm girl, and like to interact with girls
08:28
@Cast boys for potatoes
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ibtisam.midlet
found out that biohacking girls dominant longevity groups in facebook
JK 18-Sep-22 08:29 AM
What group?
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ibtisam.midlet
wanna be girl, feel I'm girl, and like to interact with girls
JK 18-Sep-22 08:29 AM
Then transfer?
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ibtisam.midlet 18-Sep-22 08:29 AM
I'm going to it matter of time
👍 1
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ibtisam.midlet
wanna be girl, feel I'm girl, and like to interact with girls
Cast 18-Sep-22 08:29 AM
Boy ur a man
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ibtisam.midlet 18-Sep-22 08:30 AM
because I pass easily
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JK 18-Sep-22 08:31 AM
Anyone has any idea, on why my veins intermittently narrow then bp rises, I start to experience confusion/stress and on top it makes all my muscles swell/tense up at least 1-2 cm (edited)
975869370045722694 1
08:32
NO works somewhat
08:32
Ain’t no fucking doc is able to find a reason (edited)
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JK
Anyone has any idea, on why my veins intermittently narrow then bp rises, I start to experience confusion/stress and on top it makes all my muscles swell/tense up at least 1-2 cm (edited)
veganpermanently 18-Sep-22 08:33 AM
oral dysbiosis
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veganpermanently
oral dysbiosis
JK 18-Sep-22 08:35 AM
No gum diseases, 29 yr never had a cavity
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JK
No gum diseases, 29 yr never had a cavity
ibtisam.midlet 18-Sep-22 08:40 AM
Where veins are
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JK
No gum diseases, 29 yr never had a cavity
veganpermanently 18-Sep-22 08:41 AM
that's not the issue
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ibtisam.midlet
Where veins are
JK 18-Sep-22 08:41 AM
Arms
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MEE6 BOT 18-Sep-22 08:41 AM
@JK, you have advanced to lvl 1 respect++ emoji_51
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JK 18-Sep-22 08:41 AM
Feels like a hammer in my chest
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veganpermanently
oral dysbiosis
Yana 18-Sep-22 08:41 AM
Ideas on how to fix (edited)
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JK
Arms
ibtisam.midlet 18-Sep-22 08:41 AM
Leg also?
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JK 18-Sep-22 08:41 AM
Yes
08:42
Swelling every limb
08:42
Face arms chest etc
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ibtisam.midlet 18-Sep-22 08:42 AM
so possibility of atherosclerosis
08:42
see photos
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Yana
Ideas on how to fix (edited)
veganpermanently 18-Sep-22 08:42 AM
yes nitrate supplementation
08:42
other than diet optimization
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ibtisam.midlet
so possibility of atherosclerosis
JK 18-Sep-22 08:42 AM
Alright ill check it out
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ibtisam.midlet 18-Sep-22 08:43 AM
in google for initial symptoms and late
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veganpermanently 18-Sep-22 08:43 AM
https://www.youtube.com/watch?v=EnkJqACCEE4
Conquer Aging Or Die Trying!
Biohacking the Oral Microbiome
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ibtisam.midlet 18-Sep-22 08:43 AM
if its correct then meds are easy
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veganpermanently 18-Sep-22 08:43 AM
nook sat fat
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veganpermanently
https://www.youtube.com/watch?v=EnkJqACCEE4
Yana 18-Sep-22 08:44 AM
Dope
08:44
Never heard of that
08:44
I get oral thrush/tongue staining easily
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veganpermanently
https://www.youtube.com/watch?v=EnkJqACCEE4
ibtisam.midlet 18-Sep-22 08:44 AM
i contacted that ytber he are soo advanced
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Yana
I get oral thrush/tongue staining easily
veganpermanently 18-Sep-22 08:44 AM
tongue staining is not oral thrush
08:45
if u do have thrush there's an easy fix
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ibtisam.midlet
in google for initial symptoms and late
JK 18-Sep-22 08:46 AM
It seems there are some correlation, and I have been eating fat heavy. Bloodwork shows elevated cholesterol (5) but triglycerides within range
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veganpermanently 18-Sep-22 08:47 AM
we should probably formulate a mouthwash that modulates microbiota instead of just nooking it
08:47
I had pretty good results from subL probiotics
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JK 18-Sep-22 08:49 AM
If I were to go about experimenting my way to an answer, what could I start with?
08:49
High dose k2?
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JK
If I were to go about experimenting my way to an answer, what could I start with?
veganpermanently 18-Sep-22 08:49 AM
just nook the sat fat
08:49
and put omegas to a balance of 1:1
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macross89 18-Sep-22 08:50 AM
Image attachment
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veganpermanently 18-Sep-22 08:51 AM
so much to optimize about diet
08:51
ppl don't pay attention at all
08:51
then wonder how they got chronic disease
08:51
if they do pay attention they do the wrong thing always
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veganpermanently
just nook the sat fat
JK 18-Sep-22 08:52 AM
I’ll try
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macross89 18-Sep-22 08:53 AM
Image attachment
08:53
975870265147940914
emoji_13 1
08:54
which medication should I use
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Cast 18-Sep-22 08:54 AM
Which one ru
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macross89 18-Sep-22 08:54 AM
I scored 27
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Cast 18-Sep-22 08:54 AM
975869370045722694
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macross89 18-Sep-22 08:54 AM
right now I use mirtazapine, without it, I can't sleep
08:54
had insomnia for like a decade
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Cast 18-Sep-22 08:55 AM
Dont take ssris
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JK 18-Sep-22 08:55 AM
It’s an snri
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Cast
Dont take ssris
veganpermanently 18-Sep-22 08:55 AM
this rly shows how noob u r
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macross89 18-Sep-22 08:55 AM
lol
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JK
It’s an snri
veganpermanently 18-Sep-22 08:55 AM
it is not
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Cast 18-Sep-22 08:55 AM
Im not the one with depression
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macross89
Click to see attachment 🖼️
ibtisam.midlet 18-Sep-22 08:55 AM
venlafaxine and magnesium and lamotrigine & Wellbutrin
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Cast
Im not the one with depression
veganpermanently 18-Sep-22 08:56 AM
u don't even deserve to talk to me
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ibtisam.midlet 18-Sep-22 08:56 AM
take one by one until it get fixed
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macross89 18-Sep-22 08:56 AM
magnesium L-threonate ?
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veganpermanently 18-Sep-22 08:56 AM
⚜️
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JK 18-Sep-22 08:56 AM
Alright no NaSSA
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Cast
Im not the one with depression
brothermanbill 18-Sep-22 08:56 AM
Why are u not jukesta anymore
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JK 18-Sep-22 08:56 AM
But almost same moa (edited)
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Cast 18-Sep-22 08:56 AM
Because
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macross89
magnesium L-threonate ?
ibtisam.midlet 18-Sep-22 08:56 AM
magnesium pidolate
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Cast 18-Sep-22 08:56 AM
I wanted a change
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ibtisam.midlet
magnesium pidolate
macross89 18-Sep-22 08:57 AM
ok
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MEE6 BOT 18-Sep-22 08:57 AM
@macross89, you have advanced to lvl 1 respect++ emoji_51
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ibtisam.midlet 18-Sep-22 08:58 AM
see the report here https://discord.com/channels/1001420842179239936/1004024673840922624/1004025149084946512
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macross89
ok
Cast 18-Sep-22 08:58 AM
Whats the cause
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veganpermanently 18-Sep-22 08:58 AM
what is the most antidepressant androgen
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Cast
I wanted a change
brothermanbill 18-Sep-22 08:58 AM
You trolled everyone and fooled them into wondering where the hell young jukesta went.
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😂 1
975869370045722694 1
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ibtisam.midlet 18-Sep-22 08:58 AM
no one took venlafaxine and didn't liked it
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veganpermanently
what is the most antidepressant androgen
brothermanbill 18-Sep-22 08:59 AM
Androsterone IME
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ibtisam.midlet 18-Sep-22 08:59 AM
its cocaine of SNRIs
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Cast
Whats the cause
macross89 18-Sep-22 08:59 AM
chronic cannabis usage induced psychosis 5 days a week at lunch time in high school, which had me have constant negative intrusive thoughts and self hate and paranoia hearing and thinking people were watching me and making fun of me 24/7 for the next 3 years of using.
975869370045722694 1
09:00
from 16 to 19
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Cast 18-Sep-22 09:00 AM
Ur prob schizoid
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macross89 18-Sep-22 09:00 AM
yeah
09:01
probably hyperdopaminergic
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veganpermanently 18-Sep-22 09:01 AM
woa woah woaah
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Cast 18-Sep-22 09:01 AM
What is one thing you want in life that you dont have and others do? @macross89
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macross89 18-Sep-22 09:01 AM
which explains my adhd like symptoms
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veganpermanently 18-Sep-22 09:01 AM
don't jump to conclusions here
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Cast
What is one thing you want in life that you dont have and others do? @macross89
macross89 18-Sep-22 09:01 AM
to not have negative self thought 24/7 and to be able to actually enjoy doing things and function properly
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macross89
chronic cannabis usage induced psychosis 5 days a week at lunch time in high school, which had me have constant negative intrusive thoughts and self hate and paranoia hearing and thinking people were watching me and making fun of me 24/7 for the next 3 years of using.
veganpermanently 18-Sep-22 09:02 AM
sounds like teen having a hard time in school
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macross89
to not have negative self thought 24/7 and to be able to actually enjoy doing things and function properly
Cast 18-Sep-22 09:02 AM
Tangible
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macross89 18-Sep-22 09:02 AM
I've been slowly reintigrating myself back into society after being a shut in for like a decade, now I'm in college in robotics and automation program
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Cast 18-Sep-22 09:02 AM
Tell me something tangible
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macross89 18-Sep-22 09:03 AM
I want meaningful relationships with friends and family and girlfriend
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macross89
I want meaningful relationships with friends and family and girlfriend
Cast 18-Sep-22 09:03 AM
Yep
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macross89 18-Sep-22 09:03 AM
and I want people to view me as successful
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Cast
What is one thing you want in life that you dont have and others do? @macross89
ibtisam.midlet 18-Sep-22 09:03 AM
lamotrigine is exactly to eliminate this feeling
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Cast 18-Sep-22 09:03 AM
Just as i thought
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veganpermanently 18-Sep-22 09:03 AM
those are heavy abstractions tho
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Cast 18-Sep-22 09:03 AM
U just need bitches
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macross89 18-Sep-22 09:03 AM
true
09:04
but I have extremely low self esteem
09:04
and can't do shit
09:04
i'm working on it
09:04
its cause of these god damn intrusive thoughts
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Cast 18-Sep-22 09:04 AM
Psychopath max with me
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Cast
U just need bitches
veganpermanently 18-Sep-22 09:04 AM
dating apps have corrupted Gen Z minds
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Cast 18-Sep-22 09:04 AM
U need to psychopath max
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MEE6 BOT 18-Sep-22 09:04 AM
@Cast, you have advanced to lvl 2 respect++ emoji_51
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veganpermanently
dating apps have corrupted Gen Z minds
macross89 18-Sep-22 09:04 AM
ol true
09:04
I think im a psychopath
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Cast 18-Sep-22 09:05 AM
No u arent
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veganpermanently 18-Sep-22 09:05 AM
the Illuminati is feeding off your simple lustful energy
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Cast 18-Sep-22 09:05 AM
Psychopaths dont have self esteem issues
09:05
And they dont get depressed
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macross89 18-Sep-22 09:05 AM
damn
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veganpermanently 18-Sep-22 09:05 AM
the only way to prevent people from feeding off your energy is to manifest a complex mindset that no one but you can understand
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Cast 18-Sep-22 09:05 AM
Psychopathy is the ticket out of this hell
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veganpermanently
the only way to prevent people from feeding off your energy is to manifest a complex mindset that no one but you can understand
Cast 18-Sep-22 09:05 AM
And psychopath max
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macross89 18-Sep-22 09:06 AM
how are their brains wired, can we hack out brains to become psychopaths or what
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veganpermanently 18-Sep-22 09:06 AM
it is a maze where everyone but you is trapped
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macross89
how are their brains wired, can we hack out brains to become psychopaths or what
Cast 18-Sep-22 09:06 AM
Decreased amygdala and orbital cortex function
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macross89 18-Sep-22 09:06 AM
i think I was a psychopath before I got fucked by cannabis
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Cast 18-Sep-22 09:06 AM
No u werent
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macross89 18-Sep-22 09:06 AM
well what can we take then
09:06
did you already do research or what
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veganpermanently 18-Sep-22 09:06 AM
it's true that cannabis makes you self aware
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Cast 18-Sep-22 09:07 AM
Im still figuring that part out. But stimualnts seem promising
09:07
Molly made me a psychopath temporarily
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veganpermanently 18-Sep-22 09:07 AM
NMDA inactivation is probably implicated
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Cast 18-Sep-22 09:07 AM
It was nice
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macross89 18-Sep-22 09:07 AM
but isnt a schizo basically alraedy have a hyperdopaminergic system
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Cast 18-Sep-22 09:07 AM
U might have maoa warrior genes
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Cast
Molly made me a psychopath temporarily
veganpermanently 18-Sep-22 09:07 AM
daily kanna use in large doses replicates this
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Cast 18-Sep-22 09:07 AM
Check this out nigger
👎 1
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macross89 18-Sep-22 09:08 AM
I took adderall for half a month and literally noticed nothing but more sweats
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MEE6 BOT 18-Sep-22 09:08 AM
@macross89, you have advanced to lvl 2 respect++ emoji_51
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veganpermanently 18-Sep-22 09:08 AM
but let me tell u
09:08
it's not enjoyable at all
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Cast 18-Sep-22 09:08 AM
https://en.m.wikipedia.org/wiki/Low_arousal_theory#:~:text=The%20low%20arousal%20theory%20is,state%20of%20abnormally%20low%20arousal. (edited)
Low arousal theory
The low arousal theory is a psychological theory explaining that people with attention-deficit hyperactivity disorder (ADHD) and antisocial personality disorder seek self-stimulation by excessive activity in order to transcend their state of abnormally low arousal. This low arousal results in the inability or difficulty to sustain attention on a...
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Cast
https://en.m.wikipedia.org/wiki/Low_arousal_theory#:~:text=The%20low%20arousal%20theory%20is,state%20of%20abnormally%20low%20arousal. (edited)
veganpermanently 18-Sep-22 09:08 AM
what kind of link is that
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macross89 18-Sep-22 09:08 AM
Kanna is fucking expensive, it's not sustainable
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Cast 18-Sep-22 09:08 AM
The kind that google uses to snip ur data
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macross89
Kanna is fucking expensive, it's not sustainable
veganpermanently 18-Sep-22 09:08 AM
nah ur poor tho
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macross89 18-Sep-22 09:09 AM
no dude liftmode extract is 100$ for not much
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Cast 18-Sep-22 09:09 AM
Trust me
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macross89 18-Sep-22 09:09 AM
and ur talking about hig doses
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Cast 18-Sep-22 09:09 AM
Psychopath maxxing is just as valuable as IQ maxxing
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macross89
no dude liftmode extract is 100$ for not much
veganpermanently 18-Sep-22 09:09 AM
5 g is ridiculous
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macross89 18-Sep-22 09:09 AM
in what sense
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veganpermanently 18-Sep-22 09:09 AM
u would die if u used that in a month
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macross89 18-Sep-22 09:10 AM
well I have it here
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macross89
in what sense
Cast 18-Sep-22 09:10 AM
In the sense that ur life becomes way easier and more enjyable
09:10
Want the psychopath pill? @macross89
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Cast
In the sense that ur life becomes way easier and more enjyable
veganpermanently 18-Sep-22 09:10 AM
presumption
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Cast
Want the psychopath pill? @macross89
macross89 18-Sep-22 09:10 AM
yeah
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veganpermanently 18-Sep-22 09:10 AM
it is hard to be a psychopath
09:10
much harder than not
09:11
mostly because u have to fake that you care all the time which takes more effort than actually caring
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macross89
yeah
Cast 18-Sep-22 09:11 AM
Basically psychopaths are highly charismatic. Get lots of pussy. Have no fear, worry or anxiety. Dont get depressed and always feel highly of themselves. They dont procrastinate and always get what they want.
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macross89 18-Sep-22 09:11 AM
I don't care and fake that I do but its because I lack self esteem
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Cast
Basically psychopaths are highly charismatic. Get lots of pussy. Have no fear, worry or anxiety. Dont get depressed and always feel highly of themselves. They dont procrastinate and always get what they want.
macross89 18-Sep-22 09:12 AM
Ok so kill anxiety, be on benzos 24/7
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Cast 18-Sep-22 09:12 AM
No
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macross89 18-Sep-22 09:12 AM
benzos "literally melt my anxiety away" "I go into stores and steal shit without a worry"
09:13
thats what I always hear from anecdotes
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veganpermanently
daily kanna use in large doses replicates this
brothermanbill 18-Sep-22 09:13 AM
Not for me lol. At the end of it i was using 120mg oral before work to make it last all shift. Went through 5g of kanna in 2 months
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macross89
benzos "literally melt my anxiety away" "I go into stores and steal shit without a worry"
Cast 18-Sep-22 09:13 AM
Yea but side effects
09:13
U wanna perma alter ur brain lad
09:13
U dont wanna rely on drugs
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macross89 18-Sep-22 09:14 AM
yeah but on them, coupled with exposure therapy you will rewire your brain
09:14
which is what im trying to do
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Cast 18-Sep-22 09:14 AM
Might work
09:14
Might not
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macross89 18-Sep-22 09:14 AM
my brain got rewired from the cannabis abuse
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Cast 18-Sep-22 09:14 AM
U gotta consider the side effects
09:14
U were never a psychopath
09:15
U were most likely adhd
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macross89 18-Sep-22 09:15 AM
apparently it dysregulates the gaba system which leads to hyper active dopamine
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Cast 18-Sep-22 09:15 AM
Hm
09:15
Ill figure it out
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macross89 18-Sep-22 09:16 AM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595795/
Adolescent THC Exposure Causes Enduring Prefrontal Cortical Disrupt...
Chronic adolescent marijuana use has been linked to the later development of psychiatric diseases such as schizophrenia. GABAergic hypofunction in the prefrontal cortex (PFC) is a cardinal pathological feature of schizophrenia and may be a mechanism by ...
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Cast 18-Sep-22 09:16 AM
Weed made u paranoid its obvious
09:16
But u can cure it
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macross89 18-Sep-22 09:17 AM
yeah with gaba
09:17
bromazopam
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Cast 18-Sep-22 09:17 AM
And stims
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macross89 18-Sep-22 09:17 AM
or whatever its called
09:17
no my brain is already hyperdopaminergic probably
09:17
why would I add more dopamine
09:17
😐
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Cast 18-Sep-22 09:17 AM
Not how it works brother
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macross89 18-Sep-22 09:18 AM
I've been starting to take phenibut
09:18
for 4-5 days now
09:18
I don't really notice much, maybe its subtle
09:18
need to try RC benzos
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Cast 18-Sep-22 09:18 AM
Fr
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MEE6 BOT 18-Sep-22 09:18 AM
@Cast, you have advanced to lvl 3 respect++ emoji_51
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brothermanbill
Not for me lol. At the end of it i was using 120mg oral before work to make it last all shift. Went through 5g of kanna in 2 months
veganpermanently 18-Sep-22 09:18 AM
I got lasting inhibition of empathetic behavior and emotions after a month of dosing Kanna daily at high doses
09:19
it wasn't cool tho
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Cast 18-Sep-22 09:19 AM
Tms can make u a psychopath
09:19
I might set it up
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veganpermanently 18-Sep-22 09:19 AM
it just made me loose a bunch of connections
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Cast 18-Sep-22 09:19 AM
It only last for 30 mins
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Netizenne 18-Sep-22 09:19 AM
Your gonna get addicted, your gonna have withdrawals You should atleast try to limit phenibut to like 500-750mg a week whenever needed (so not everyday)
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macross89 18-Sep-22 09:19 AM
Tms ? what is that
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veganpermanently
I got lasting inhibition of empathetic behavior and emotions after a month of dosing Kanna daily at high doses
brothermanbill 18-Sep-22 09:21 AM
Oh actually yeah i see what you’re saying there. When i quit it i was already going through a hard time of my life and i was very zombie and dysfunctional and i felt like kanna was making me slow but also improving some aspects of quality on my life
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macross89 18-Sep-22 09:21 AM
sometimes I wonder if my brain needs cannabis cause it got addicted
09:22
I started taking liquid isolate concentrates again but very little sublingual, can't say I notice anything really
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macross89
sometimes I wonder if my brain needs cannabis cause it got addicted
veganpermanently 18-Sep-22 09:22 AM
I abused Cannabis far more then you
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macross89 18-Sep-22 09:22 AM
then I stopped
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MEE6 BOT 18-Sep-22 09:22 AM
@macross89, you have advanced to lvl 3 respect++ emoji_51
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veganpermanently 18-Sep-22 09:22 AM
and yeah life is harder to navigate if I don't dose in a month
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macross89
Tms ? what is that
Cast 18-Sep-22 09:22 AM
Transcranial magentic stimulation
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macross89 18-Sep-22 09:23 AM
lol
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veganpermanently
it just made me loose a bunch of connections
brothermanbill 18-Sep-22 09:23 AM
Dude funny thing is i gave my friends their first time with kanna intranasal and they were very connecting and god-consciousness and loved how it felt so nice outside
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MEE6 BOT 18-Sep-22 09:23 AM
@brothermanbill, you have advanced to lvl 1 respect++ emoji_51
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macross89 18-Sep-22 09:23 AM
the one where you wear a hat
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brothermanbill
Dude funny thing is i gave my friends their first time with kanna intranasal and they were very connecting and god-consciousness and loved how it felt so nice outside
veganpermanently 18-Sep-22 09:23 AM
never give people your drugs
09:23
that's just stupid
09:24
I stopped even talking about it
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brothermanbill 18-Sep-22 09:24 AM
They gave me drugs though
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veganpermanently 18-Sep-22 09:24 AM
if anyone asks me I just drink coffee
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brothermanbill 18-Sep-22 09:24 AM
Bruh dafuq. emoji_27
emoji_1 1
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veganpermanently 18-Sep-22 09:24 AM
u could never tell I'm VP if you met me in person
💟 1
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Cast 18-Sep-22 09:25 AM
Any drugs that directly effect the amygdala?
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brothermanbill 18-Sep-22 09:25 AM
I will say i smoke crack to the president of the united states i do not give a fork.
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Cast
Any drugs that directly effect the amygdala?
brothermanbill 18-Sep-22 09:25 AM
Nsi-189 grows it. Bpc-157 probably too (edited)
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Netizenne 18-Sep-22 09:25 AM
I felt like a psychopath while one NSI
✅ 1
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brothermanbill
I will say i smoke crack to the president of the united states i do not give a fork.
veganpermanently 18-Sep-22 09:25 AM
I don't give a fuck either that's why I lie 983795135575883818
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brothermanbill
Nsi-189 grows it. Bpc-157 probably too (edited)
Cast 18-Sep-22 09:25 AM
Shrink it
09:26
What drugs shrink it
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Cast
What drugs shrink it
brothermanbill 18-Sep-22 09:26 AM
Cyproheptadine
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brothermanbill
Cyproheptadine
veganpermanently 18-Sep-22 09:26 AM
nice
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macross89 18-Sep-22 09:26 AM
I think I just need therapy lol, think my issue is just lack of confidence, I've tried adderall and phenibut with no noticeable effects, those are like the top of each category of receptor acting drugs before we pass the threshold into meth and benzos
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veganpermanently 18-Sep-22 09:26 AM
roflmao
09:26
hypocampus depends on amygdala
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brothermanbill
Cyproheptadine
Cast 18-Sep-22 09:27 AM
Side effects?
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veganpermanently 18-Sep-22 09:27 AM
shrinking amygdala will nook your memory
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veganpermanently
shrinking amygdala will nook your memory
Cast 18-Sep-22 09:27 AM
How to become a psychopath
09:27
I dont rely on emotions for memory usually
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Cast
What drugs shrink it
brothermanbill 18-Sep-22 09:27 AM
TAAR1 antagonists, protein kinase inhibitors, some sort of tryptamine-inhibitors/reducers
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macross89 18-Sep-22 09:27 AM
I fixed my issues before by going through hell for 4 months re-integrating myself into society, meditation (mindfulness), daily gym, job, anti inflammatory diet (edited)
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Cast 18-Sep-22 09:27 AM
My brain and mindset is already in the best state for psychopathy
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Netizenne 18-Sep-22 09:28 AM
NSI provides alot of control switching outwardly projected emotional states when needed ime (edited)
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macross89 18-Sep-22 09:28 AM
but then I fell back down once my shifts got changed back to night shifts on weekends and had to work with asshole and assholes came to job place cause casino is right next door
09:28
975870265147940914
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Cast
How to become a psychopath
veganpermanently 18-Sep-22 09:28 AM
I jsut realized ur trying to MK Ultra yourself
09:29
roflmao
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veganpermanently
I jsut realized ur trying to MK Ultra yourself
Cast 18-Sep-22 09:29 AM
Wasnt that lsd + ptsd?
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Cast
Wasnt that lsd + ptsd?
veganpermanently 18-Sep-22 09:29 AM
yeah but their goal was to make psychopaths
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Netizenne
NSI provides alot of control switching outwardly projected emotional states when needed ime (edited)
JK 18-Sep-22 09:29 AM
That is borderline psychopathic lol
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Cast 18-Sep-22 09:29 AM
Did it work? (edited)
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Cast
Did it work? (edited)
veganpermanently 18-Sep-22 09:30 AM
depends.
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JK 18-Sep-22 09:30 AM
But nice, right behind ya
09:30
Need this in my life
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Netizenne
NSI provides alot of control switching outwardly projected emotional states when needed ime (edited)
macross89 18-Sep-22 09:30 AM
why isn't it more talked about then
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JK
That is borderline psychopathic lol
Netizenne 18-Sep-22 09:30 AM
It felt like it Like I could do the Ren and Stimpy thing where he begins to look almost calm when angry looool (edited)
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Cast 18-Sep-22 09:30 AM
Are you sure that was mk ultra @veganpermanently
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macross89
why isn't it more talked about then
Netizenne 18-Sep-22 09:30 AM
There’s been lots of discussion on nsi
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Cast
Are you sure that was mk ultra @veganpermanently
veganpermanently 18-Sep-22 09:31 AM
ye
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Cast 18-Sep-22 09:31 AM
I thought mk ultra was for hypnosis and interragation
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Cast
I thought mk ultra was for hypnosis and interragation
veganpermanently 18-Sep-22 09:31 AM
well yeah that's what they told the public
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macross89 18-Sep-22 09:31 AM
when people talk about controlling emotions and intrusive thoughts and shit on reddit, the only thing I read is NAC
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Netizenne
It felt like it Like I could do the Ren and Stimpy thing where he begins to look almost calm when angry looool (edited)
JK 18-Sep-22 09:31 AM
Image attachment
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MEE6 BOT 18-Sep-22 09:31 AM
@JK, you have advanced to lvl 2 respect++ emoji_51
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brothermanbill 18-Sep-22 09:31 AM
February-march 2020 I was extreme psychopath with severe GABA-A downregulation, extreme GABA-b agonism, extreme D2 agonism, and extreme weed withdrawals. But that was like the highlight of my life cuz i felt like everything was grandiose grandeur delusion
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veganpermanently 18-Sep-22 09:31 AM
if they told the public they just wanted to make serial killers CIA would be no more
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Cast 18-Sep-22 09:32 AM
Also i have noticed something akin to that on lsd
09:32
Was in a bad enviroment on lsd and afterwards i became more psychopathic
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JK 18-Sep-22 09:32 AM
NSI + Novichock = Win
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Cast 18-Sep-22 09:33 AM
It just dissolved my morality a bit
09:33
Made me see things not so black and white
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JK 18-Sep-22 09:33 AM
You’ve always been psychopathic Jukesta
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Cast 18-Sep-22 09:33 AM
No im not
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Cast
Was in a bad enviroment on lsd and afterwards i became more psychopathic
brothermanbill 18-Sep-22 09:33 AM
ETH-LAD + AL-LAD = god
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JK 18-Sep-22 09:34 AM
I’m joking
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veganpermanently 18-Sep-22 09:34 AM
DHEA 7DHA ACP-105 we need an ERB agonist ASAP
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JK 18-Sep-22 09:34 AM
Also, u still feeling the after effects of DFO?
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veganpermanently 18-Sep-22 09:34 AM
I can't believe these bodybuilding websites don't list any
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Cast 18-Sep-22 09:34 AM
I dont know what dfo does
09:35
In the 10 minutes after dosing there is a slight euphoria. But it was definetly over hyped
09:35
I did 1.75g and never touched it since
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veganpermanently
DHEA 7DHA ACP-105 we need an ERB agonist ASAP
brothermanbill 18-Sep-22 09:35 AM
What does dhea and pregnenolone a 3-methoxy-pregnanolone do to ERB
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macross89 18-Sep-22 09:35 AM
Why are people giving anecdotes of NSI making them more emotional but then the other dude says it makes him able to control his emotions :bruh:
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veganpermanently 18-Sep-22 09:35 AM
Image attachment
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macross89 18-Sep-22 09:36 AM
975870265147940914
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Cast 18-Sep-22 09:36 AM
Dont take nsi unless u want to be a pussy
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Cast
I did 1.75g and never touched it since
brothermanbill 18-Sep-22 09:36 AM
I’ll do 500mg tomorrow intranasal wallah. I still use it and dont regret using multiple grams intranasal it is really good to use because nothing is as strong to chelate neuronal iron
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Cast
Dont take nsi unless u want to be a pussy
brothermanbill 18-Sep-22 09:37 AM
I have had very opposite experiences in a wide span of time frame on nsi-189 freebase specifically
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Cast
I did 1.75g and never touched it since
JK 18-Sep-22 09:37 AM
1.75g is a lot no?
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macross89 18-Sep-22 09:37 AM
we need to get rid of empathy
✅ 2
09:37
and pussyness
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macross89
we need to get rid of empathy
brothermanbill 18-Sep-22 09:37 AM
Acetaminophen
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macross89 18-Sep-22 09:37 AM
no it damages the intestinal lining or something
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JK
1.75g is a lot no?
Cast 18-Sep-22 09:37 AM
About 3 n a half doses
09:38
We have to figure out a safe way to become psychopaths
👍 1
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Cast
About 3 n a half doses
brothermanbill 18-Sep-22 09:38 AM
I get headache from dfo even at 200mg wbu
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MEE6 BOT 18-Sep-22 09:38 AM
@brothermanbill, you have advanced to lvl 2 respect++ emoji_51
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JK 18-Sep-22 09:38 AM
Bonk says it cured his lifetime of headaches (edited)
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macross89 18-Sep-22 09:38 AM
yeah
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brothermanbill
I get headache from dfo even at 200mg wbu
Cast 18-Sep-22 09:38 AM
Nope
09:38
I took 500 mg first day
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Cast
We have to figure out a safe way to become psychopaths
brothermanbill 18-Sep-22 09:39 AM
Shilajit megadose + tongkat + cistanche + hydroxybetacholesterol, and eating turkey hearts
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Cast 18-Sep-22 09:39 AM
I shot it up my nose just like pax did
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macross89 18-Sep-22 09:39 AM
where was acetominophen from
09:39
advil or tylenol
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Cast
Dont take nsi unless u want to be a pussy
Netizenne 18-Sep-22 09:39 AM
It doesn’t do that lol
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veganpermanently 18-Sep-22 09:39 AM
I found a better drug than DFO
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Cast
I shot it up my nose just like pax did
brothermanbill 18-Sep-22 09:39 AM
I will buy the remaining vials off you man ❤️
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Cast
We have to figure out a safe way to become psychopaths
JK 18-Sep-22 09:39 AM
Megadose lithium orotate?
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veganpermanently 18-Sep-22 09:39 AM
10x more potent
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brothermanbill
Shilajit megadose + tongkat + cistanche + hydroxybetacholesterol, and eating turkey hearts
Cast 18-Sep-22 09:39 AM
Is this jokes?
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veganpermanently
I found a better drug than DFO
Cast 18-Sep-22 09:39 AM
?
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JK
Megadose lithium orotate?
Cast 18-Sep-22 09:40 AM
Reasoning?
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macross89 18-Sep-22 09:40 AM
I think we're all just lazy and unhealthy
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Cast
Is this jokes?
brothermanbill 18-Sep-22 09:40 AM
Stg i have been taking $7-10 of shilajit resin daily for the past 2 weeks
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Cast
Reasoning?
JK 18-Sep-22 09:40 AM
Flatlined emotional spectrum
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Cast
?
veganpermanently 18-Sep-22 09:40 AM
ciclopirox
09:40
10x more effective at erythropoiesis
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JK
Flatlined emotional spectrum
Cast 18-Sep-22 09:40 AM
Really
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veganpermanently 18-Sep-22 09:41 AM
with less iron chelation
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brothermanbill 18-Sep-22 09:41 AM
Megadose shilajit was kept secret by the master yogi’s in ancient india
975869370045722694 1
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Cast 18-Sep-22 09:41 AM
Does it flatline fear?
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Cast
Really
JK 18-Sep-22 09:41 AM
And drive, and motivation and everything u need to utilize your psychopathy
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brothermanbill 18-Sep-22 09:41 AM
They were gods of meditation and telepathy
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macross89 18-Sep-22 09:41 AM
megadosing is unsustainable with like all of these supplements
09:41
you will be broke
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JK
And drive, and motivation and everything u need to utilize your psychopathy
Cast 18-Sep-22 09:41 AM
Permanent or acute changes?
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Cast
Permanent or acute changes?
JK 18-Sep-22 09:42 AM
No idea
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Cast 18-Sep-22 09:42 AM
Thats the most important factor
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macross89 18-Sep-22 09:42 AM
man
09:42
permanent changes probably require abusing drugs
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JK 18-Sep-22 09:42 AM
Acute change just kill aomeone
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Cast 18-Sep-22 09:42 AM
U want to become a psychopath permanetly
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macross89 18-Sep-22 09:42 AM
and exposing yourself daily to whatever
09:43
for like a couple years
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Cast 18-Sep-22 09:43 AM
Tms + rapamycin could do it (edited)
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JK 18-Sep-22 09:43 AM
In all seriousness
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macross89 18-Sep-22 09:44 AM
I wonder if you can get autoimmune disease or MCAS from hanging weights from your dick
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JK 18-Sep-22 09:44 AM
I hardly think nuking your emotional specteum is functional with regards to whatever you want to achieve. Perhaps a more functional egoism is better to strive for
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macross89 18-Sep-22 09:44 AM
maybe that's why I have symptoms of autoimmune disease or mcas
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JK
I hardly think nuking your emotional specteum is functional with regards to whatever you want to achieve. Perhaps a more functional egoism is better to strive for
Cast 18-Sep-22 09:45 AM
Do you think no emotional specturm = psychopathy since i dont know
09:45
Psychopaths are highly productive
09:45
Goal driven
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Cast
Do you think no emotional specturm = psychopathy since i dont know
JK 18-Sep-22 09:45 AM
More sociopathy, but I think psychopaths lack empathy
09:45
I don’t know much about it
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macross89 18-Sep-22 09:45 AM
anyone tried acetominophen for a long period of time
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Cast 18-Sep-22 09:45 AM
U should watch some james fallon
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macross89 18-Sep-22 09:45 AM
for its emotional blunting effects
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Cast 18-Sep-22 09:46 AM
Hes a neuroscientist who discovered he was a psychopath
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JK 18-Sep-22 09:46 AM
Ah that guy
09:46
Yea I know
09:46
Found the epigenetic tendencies towards psychopathic predispositions
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macross89 18-Sep-22 09:46 AM
I wonder if theres anything that can reduce or prevent the damage acetominophen does to the stomach lining
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JK 18-Sep-22 09:46 AM
Remember a documentary where he found out he was predisposed himself
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Netizenne 18-Sep-22 09:47 AM
Secondary psychpaths -the anxious, impulsive, and more destructive type- I would take NSI for. And then D-serine for fear learning and verbal wit/charisma.
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macross89 18-Sep-22 09:47 AM
did you try d serine
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Netizenne 18-Sep-22 09:47 AM
D-serine apparently improves verbal iq
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macross89
did you try d serine
Netizenne 18-Sep-22 09:47 AM
Not yet
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macross89 18-Sep-22 09:47 AM
🙄
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JK 18-Sep-22 09:47 AM
I will probably get on it soon also
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macross89 18-Sep-22 09:47 AM
why would you take NSI
09:48
literally everyone says it makes them more emotionally vulnerable basically
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JK 18-Sep-22 09:48 AM
But the neurotoxic potential I don’t like
09:48
From d-serine
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Netizenne
Secondary psychpaths -the anxious, impulsive, and more destructive type- I would take NSI for. And then D-serine for fear learning and verbal wit/charisma.
Cast 18-Sep-22 09:48 AM
D serine for fear learning?
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Netizenne 18-Sep-22 09:48 AM
Vulnerability has its uses Good for stuff like music
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Cast 18-Sep-22 09:48 AM
Wouldnt it induce fear extinction?
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macross89 18-Sep-22 09:48 AM
yeah but I don't care about music
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MEE6 BOT 18-Sep-22 09:48 AM
@macross89, you have advanced to lvl 4 respect++ emoji_51
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Netizenne 18-Sep-22 09:48 AM
Being very emotional in general is good for music
👍 3
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JK 18-Sep-22 09:49 AM
Was just about to say
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MEE6 BOT 18-Sep-22 09:49 AM
@JK, you have advanced to lvl 3 respect++ emoji_51
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macross89 18-Sep-22 09:49 AM
lol
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Netizenne
Being very emotional in general is good for music
Cast 18-Sep-22 09:49 AM
Dont be emotional
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JK 18-Sep-22 09:49 AM
I make music as a side, and want to do it fully
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macross89 18-Sep-22 09:49 AM
I've always considered D-Serine
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JK 18-Sep-22 09:49 AM
I don’t want to nuke my emotions lol
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macross89 18-Sep-22 09:49 AM
music makes you gay
09:49
look at all the music producers
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Cast 18-Sep-22 09:49 AM
Psychopathy maxxing is based
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MEE6 BOT 18-Sep-22 09:49 AM
@Cast, you have advanced to lvl 4 respect++ emoji_51
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JK 18-Sep-22 09:49 AM
But it would damn sure help with the business side of things
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a r c t !^ 18-Sep-22 09:49 AM
Discord makes you gay
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a r c t !^
Discord makes you gay
macross89 18-Sep-22 09:50 AM
stop projecting
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Cast 18-Sep-22 09:50 AM
I thiught dserine = fear extinction
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JK 18-Sep-22 09:50 AM
Gays make u straight
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macross89 18-Sep-22 09:50 AM
975870265147940914
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JK 18-Sep-22 09:50 AM
If u aren’t gay that is
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JK
Gays make u straight
macross89 18-Sep-22 09:50 AM
lol this is true
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macross89
literally everyone says it makes them more emotionally vulnerable basically
Netizenne 18-Sep-22 09:50 AM
It’s thought that one of the main functions of variance in emotional intensity is to assign value to memories -that the more emotional an experience the better it’s remembered.
👍 1
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JK 18-Sep-22 09:51 AM
I thought nsi made you more emotional?
ibtisam.midlet pinned a message to this channel. 18-Sep-22 09:51 AM
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Netizenne
It’s thought that one of the main functions of variance in emotional intensity is to assign value to memories -that the more emotional an experience the better it’s remembered.
Cast 18-Sep-22 09:51 AM
Pure memory is better
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macross89 18-Sep-22 09:51 AM
but what if my experiences are always bad due to my ruminations
09:51
would it not make things worse
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Cast 18-Sep-22 09:51 AM
It would
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Netizenne 18-Sep-22 09:51 AM
Amygdala is part of the hippocampus -the primary part of the brain involved in memory many would say (edited)
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Cast 18-Sep-22 09:51 AM
Dont take nsi if ur emotional
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macross89 18-Sep-22 09:51 AM
nsi is gae
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veganpermanently 18-Sep-22 09:51 AM
found sauce for ciclopirox
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Netizenne 18-Sep-22 09:51 AM
Emotion and memory are very linked
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Cast 18-Sep-22 09:51 AM
Dont take nsi if ur unstable
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macross89 18-Sep-22 09:51 AM
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JK 18-Sep-22 09:52 AM
Why not?
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Netizenne
Emotion and memory are very linked
Cast 18-Sep-22 09:52 AM
Not if u learn to memorize things unemotionally
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macross89
stop projecting
a r c t !^ 18-Sep-22 09:52 AM
I’m not gay I’m shy
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JK 18-Sep-22 09:52 AM
Like psilocybin for schizophrenia?
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Netizenne 18-Sep-22 09:52 AM
I found NSI to make me the opposite of a pussy tbh I stood up to my parents drunken arguing they’re always engaging in and have gotten them to stop for a while (edited)
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macross89 18-Sep-22 09:52 AM
maybe I need to get back on NAC, It made me unable to sleep and I alraedy have insomnia, but since I staretd mirtazapine I sleep ez n fast and good
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Cast
Not if u learn to memorize things unemotionally
JK 18-Sep-22 09:52 AM
That seems so wrong
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Cast 18-Sep-22 09:53 AM
Its not
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JK 18-Sep-22 09:53 AM
I probably not it just seems like that imo
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Netizenne
Being very emotional in general is good for music
brothermanbill 18-Sep-22 09:53 AM
Opioid withdrawalemoji_1
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macross89 18-Sep-22 09:53 AM
NAC makes you gay, but at least I won't have OCD and be emotional
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JK 18-Sep-22 09:53 AM
Like I associate memorize with a lot of sensory impressions
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macross89 18-Sep-22 09:53 AM
hopefully
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JK 18-Sep-22 09:53 AM
Smells etc
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Netizenne 18-Sep-22 09:53 AM
Sure, there’s lot of reasons to dislike NSI (it will have you acting psychopathic a tad maybe) but thinking that it makes you a ‘gae pussy’ is not why you should dislike it (edited)
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JK 18-Sep-22 09:53 AM
And they correlate to a specific mindset and feeling
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macross89 18-Sep-22 09:54 AM
NAC effects the NAC receptor which is used to modulate emotions relating to gay
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Cast 18-Sep-22 09:54 AM
U dont have to
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veganpermanently 18-Sep-22 09:54 AM
anything unemotionally is subhuman
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macross89 18-Sep-22 09:54 AM
it agonizes the NAC receptor, in turn makes you gay
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Cast 18-Sep-22 09:54 AM
I can recall 90% of events that u had no emotional connection to
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veganpermanently
anything unemotionally is subhuman
JK 18-Sep-22 09:54 AM
Or epi (edited)
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veganpermanently 18-Sep-22 09:54 AM
it's lame really
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JK 18-Sep-22 09:54 AM
I agree
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veganpermanently 18-Sep-22 09:55 AM
the thought that u need to castrate yourself emotionally to get ahead
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JK 18-Sep-22 09:55 AM
But it has its functionality
09:55
In some aspects of life
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Cast 18-Sep-22 09:55 AM
Emotions are hinderance
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JK 18-Sep-22 09:55 AM
Like needing to be an asshole to your sidebich when she wants to be serious
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JK
In some aspects of life
veganpermanently 18-Sep-22 09:55 AM
yeah in low IQ professions
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JK 18-Sep-22 09:55 AM
You feel bad about it
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veganpermanently 18-Sep-22 09:55 AM
like police force
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JK 18-Sep-22 09:55 AM
But you need too
09:55
I don’t agree with that
09:55
But sure
09:56
Police in Denmark are over average in terms of fluent intelligence
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JK
Police in Denmark are over average in terms of fluent intelligence
veganpermanently 18-Sep-22 09:56 AM
here you can't get a job in police if you're above 120 IQ
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JK 18-Sep-22 09:56 AM
jees
09:56
Where is that?
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macross89 18-Sep-22 09:56 AM
I don't really care about IQ, in the end if I have no emotions and Im a psychopath I can control people and get what I want
emoji_1 1
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veganpermanently 18-Sep-22 09:56 AM
Croatia
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Cast 18-Sep-22 09:56 AM
Literally?
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macross89 18-Sep-22 09:56 AM
like sure its nice to have
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Cast
Literally?
veganpermanently 18-Sep-22 09:57 AM
yes
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macross89
I don't really care about IQ, in the end if I have no emotions and Im a psychopath I can control people and get what I want
Cast 18-Sep-22 09:57 AM
Exactly
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JK 18-Sep-22 09:57 AM
Ah yeah, all cro cops
09:57
I see
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JK
And they correlate to a specific mindset and feeling
Netizenne 18-Sep-22 09:57 AM
The goal your memorizing stuff for the sake of accomplishing is probably motivated by emotion
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Cast 18-Sep-22 09:57 AM
@macross89 lets start a small research group
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macross89 18-Sep-22 09:57 AM
well use benzos
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Netizenne
The goal your memorizing stuff for the sake of accomplishing is probably motivated by emotion
JK 18-Sep-22 09:57 AM
That resonates
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macross89 18-Sep-22 09:57 AM
emoji_50
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Cast 18-Sep-22 09:58 AM
Accept my request
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macross89 18-Sep-22 09:58 AM
no dud
09:58
I cant commit
09:58
i have school n shit
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JK 18-Sep-22 09:58 AM
Brothers u will end up in jail
emoji_51 2
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Cast 18-Sep-22 09:58 AM
No commitment
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JK 18-Sep-22 09:58 AM
Or dead
09:58
It’s not functional long term
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Cast 18-Sep-22 09:58 AM
Just a place to post studies my guy
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macross89 18-Sep-22 09:58 AM
I dont have time for that
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JK
It’s not functional long term
Cast 18-Sep-22 09:58 AM
Look up pro social psychopaths
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veganpermanently 18-Sep-22 09:59 AM
we should move somewhere where no one can find us
09:59
then make MK Ultra again
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JK 18-Sep-22 09:59 AM
I always thought I had it in me to kill someone, and I probably do. Few weeks ago I was attacked, and held the guy down while the fucker bit me etc.
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veganpermanently 18-Sep-22 09:59 AM
emoji_52
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Cast
Look up pro social psychopaths
Netizenne 18-Sep-22 09:59 AM
That seems so contradictory, psychopathy is literally called “antisocial personality disorder” more formally
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JK 18-Sep-22 09:59 AM
Do I want to fo to jail?
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Cast 18-Sep-22 09:59 AM
Lets go psychopath maxxing
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JK 18-Sep-22 10:00 AM
No
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Netizenne
That seems so contradictory, psychopathy is literally called “antisocial personality disorder” more formally
Cast 18-Sep-22 10:00 AM
Two types of social
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JK 18-Sep-22 10:00 AM
You need empathy and emotions to regulate your actions
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JK
I always thought I had it in me to kill someone, and I probably do. Few weeks ago I was attacked, and held the guy down while the fucker bit me etc.
veganpermanently 18-Sep-22 10:00 AM
perfect test
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JK 18-Sep-22 10:00 AM
Yup
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Cast 18-Sep-22 10:00 AM
Social as in good at communicating and social as in valuing society
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JK 18-Sep-22 10:00 AM
I thought long about it
10:00
Could bashes his head in the asphalt
10:00
But why?
10:00
He was on drugs, drunk
10:01
Talked about suicidal
10:01
Poor fella was in pain
10:01
And I don’t like small spaces
10:01
And getting ass raped by bikers
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JK
But why?
veganpermanently 18-Sep-22 10:01 AM
to enforce cultural evolution like all real men did before u
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Cast 18-Sep-22 10:01 AM
If ur iq is above 115 you can become a psychopath without worry
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JK 18-Sep-22 10:01 AM
Mine is 142 on Norwegian Mensa
10:01
And I’m not
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Cast 18-Sep-22 10:02 AM
U would make a good psychopath
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Cast
U would make a good psychopath
veganpermanently 18-Sep-22 10:02 AM
y r u so autistic
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Cast 18-Sep-22 10:02 AM
Chris watts is a low Iq psychopath
10:02
https://youtu.be/2ZJzEZ8Y-rM
Derek Van Schaik
Watch How Police Caught Chris Watts, Family Murderer, With Body Lan...
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JK 18-Sep-22 10:03 AM
People with this white teeth always up to something
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veganpermanently 18-Sep-22 10:03 AM
if u don't have children by 25 ur not psychopath
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Cast 18-Sep-22 10:03 AM
Low IQ psychopath < neurotypical < high IQ psychopath
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veganpermanently 18-Sep-22 10:04 AM
at really high IQ psychopathy will be only a burden
10:04
for high IQ people it's easy to override empathetic thought
10:04
that means you can't feel empathy only when you need it
10:04
there is no usecase
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JK 18-Sep-22 10:04 AM
Yea unless you have a aspergers and grew up with daddy’s goldmine capital
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macross89 18-Sep-22 10:05 AM
anyways maybe my new stack will include D-Serine and NAC
10:05
haven't tried D-serine yet
10:05
just sick and tired of using all these god damn BS herbs and supplements that do fuck all lol
💀 1
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JK 18-Sep-22 10:05 AM
Try it with NSI, and go fix the economy
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veganpermanently
at really high IQ psychopathy will be only a burden
judas 18-Sep-22 10:05 AM
Pretty much
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macross89 18-Sep-22 10:05 AM
what really works is pharma
10:05
and RCs
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JK 18-Sep-22 10:05 AM
And empathy!
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macross89 18-Sep-22 10:06 AM
if you want to live forever stop buying dumb ass herbs, just get metformin, rapamycin and SKQ1
10:06
you don't need 100 herbs
10:06
to barely have the effect of one of the above (edited)
10:06
975870265147940914
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veganpermanently 18-Sep-22 10:06 AM
berberine
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JK 18-Sep-22 10:06 AM
The immune suppressive aspect of raps scares me
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veganpermanently 18-Sep-22 10:06 AM
PQQ
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macross89 18-Sep-22 10:06 AM
alternate between berberine and metformin 1:1 apparently
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JK 18-Sep-22 10:07 AM
But I don’t have diabetussss?
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veganpermanently 18-Sep-22 10:07 AM
metformin nooks muscle
10:07
berberine improves it
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macross89 18-Sep-22 10:07 AM
theres a study that shows that people with diabetus that take metformin live 15% longer than people without diabetus that take metformin, idk I just read the title (edited)
10:07
somebody posted it in nootopics
10:08
edit
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macross89
if you want to live forever stop buying dumb ass herbs, just get metformin, rapamycin and SKQ1
brothermanbill 18-Sep-22 10:08 AM
Whats the best source for skq1
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JK 18-Sep-22 10:08 AM
Yeah I got it
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macross89 18-Sep-22 10:08 AM
idk I just use sirsad
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JK 18-Sep-22 10:08 AM
Cosmic has no?
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MEE6 BOT 18-Sep-22 10:08 AM
@JK, you have advanced to lvl 4 respect++ emoji_51
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veganpermanently
for high IQ people it's easy to override empathetic thought
Cast 18-Sep-22 10:08 AM
Yep
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macross89 18-Sep-22 10:08 AM
and I use mitovan for skincare
10:08
which uses SQK1
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JK 18-Sep-22 10:08 AM
I will try their mitovan
10:08
At some point
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macross89 18-Sep-22 10:08 AM
its expensive
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Cast 18-Sep-22 10:08 AM
But its not all about empathy
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macross89 18-Sep-22 10:08 AM
you could try the concentrate that is like half price and mix it with your skincare products
10:08
motivitan i think
10:09
mitovitan
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Cast 18-Sep-22 10:09 AM
Psychopathic motivation is real
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JK 18-Sep-22 10:09 AM
That’s what I was thinking
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Cast
But its not all about empathy
veganpermanently 18-Sep-22 10:09 AM
the reason you don't see smart people doing unempathetic stuff is because in most cases it's not the optimal thing to do
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JK 18-Sep-22 10:09 AM
Mixing it with normal moisturizer
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macross89 18-Sep-22 10:09 AM
also apparently hyaluronic acid ingested is better than applied topically
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brothermanbill 18-Sep-22 10:09 AM
Fuck my life i accidentally deleted my comment
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macross89 18-Sep-22 10:09 AM
as long as its a small enough molecule
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JK 18-Sep-22 10:09 AM
We won’t survive as a species without empathy?
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veganpermanently
the reason you don't see smart people doing unempathetic stuff is because in most cases it's not the optimal thing to do
Cast 18-Sep-22 10:09 AM
But they will when they have to
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JK 18-Sep-22 10:09 AM
The lack of it is why we are fucked
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Cast
But they will when they have to
veganpermanently 18-Sep-22 10:10 AM
ofc
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Cast 18-Sep-22 10:10 AM
Kill or be killed
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macross89 18-Sep-22 10:10 AM
fuckkkk
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Cast 18-Sep-22 10:10 AM
Psychopathy is the meta rn
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veganpermanently 18-Sep-22 10:10 AM
it's like asking me what would I do on a desert island as a vegan
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JK 18-Sep-22 10:10 AM
Find the core of the self, and understand empathy
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veganpermanently 18-Sep-22 10:10 AM
dumb question
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macross89 18-Sep-22 10:10 AM
acetominophen why does it have to damage stomach lining or whatever
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Cast
Psychopathy is the meta rn
brothermanbill 18-Sep-22 10:11 AM
I agree i want psychopathy again. But i would have to quit weed for sure
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brothermanbill
I agree i want psychopathy again. But i would have to quit weed for sure
JK 18-Sep-22 10:12 AM
The month after quitting weed is pure mental darkness
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JK
The month after quitting weed is pure mental darkness
veganpermanently 18-Sep-22 10:12 AM
what r u talking about
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JK 18-Sep-22 10:12 AM
Archetypical shadow stuff, I just wanted to kill and do illegal stuff
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Cast
But they will when they have to
brothermanbill 18-Sep-22 10:13 AM
More like when they don’t have to. They are more likely to be forced into empathy rather than expressing it.
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JK
Archetypical shadow stuff, I just wanted to kill and do illegal stuff
veganpermanently 18-Sep-22 10:13 AM
should have made a drug empire
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JK 18-Sep-22 10:13 AM
I considered it a rage state almost. Like a subconscious resilience
10:13
Dude
10:13
I even thought about it
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Cast 18-Sep-22 10:13 AM
I think lsd and ptsd will do it bois
10:14
After that lots of addy
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JK 18-Sep-22 10:14 AM
Now I’m out here preaching peace
10:14
Tf happened
10:14
Eyo Jukesta maybe im in
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Cast 18-Sep-22 10:14 AM
Gktta force my brain into a goal oriented mindset
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JK
I even thought about it
veganpermanently 18-Sep-22 10:14 AM
do u have connections
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JK 18-Sep-22 10:14 AM
Let’s go get psyched
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Cast 18-Sep-22 10:14 AM
Nice
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veganpermanently
do u have connections
JK 18-Sep-22 10:14 AM
Everyone in my country has
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veganpermanently 18-Sep-22 10:15 AM
that doesn't give u an edge
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JK 18-Sep-22 10:15 AM
That’s true
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Cast 18-Sep-22 10:15 AM
Im in a state where i have no reason to not be a psychopath. No love, dont talk to many. I already trust no one
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JK 18-Sep-22 10:15 AM
None for bulk over 500g etc
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Cast
Im in a state where i have no reason to not be a psychopath. No love, dont talk to many. I already trust no one
JK 18-Sep-22 10:16 AM
Go hug a random
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macross89 18-Sep-22 10:16 AM
make eye contact with everyone you see, thats how you become dominant alpha chad bussin fr fr no cap dead ass aint finna lie male
10:17
you will not sis
10:17
sus
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JK
I considered it a rage state almost. Like a subconscious resilience
brothermanbill 18-Sep-22 10:17 AM
Yeah first time in my life rn im like damn bro its either i quit my daily smoking and hope i can feel cognitively and emotionally better or i keep smoking to keep the piling stress at bay and not flip out, cuz im very prone to flip out on the wrong people because i don’t know what to rage to or what to rage at
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Cast 18-Sep-22 10:18 AM
I miss what molly did to me
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brothermanbill
Yeah first time in my life rn im like damn bro its either i quit my daily smoking and hope i can feel cognitively and emotionally better or i keep smoking to keep the piling stress at bay and not flip out, cuz im very prone to flip out on the wrong people because i don’t know what to rage to or what to rage at
JK 18-Sep-22 10:18 AM
Exactly my experience my man. Almost animalistic tendencies, I swear I could have hurt someone I loved.
10:18
I would quit
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Cast 18-Sep-22 10:18 AM
Molly made me invincible
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JK 18-Sep-22 10:18 AM
You WILL get back to “a” baseline
10:19
It’s not the old you, but you are in control. And that’s all worth it imo
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Cast
Molly made me invincible
brothermanbill 18-Sep-22 10:20 AM
I did mdma like 12 times and i agree but at the same time i can’t remember any of my experiences except for a few. I never went over 150mg oral wbu
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veganpermanently 18-Sep-22 10:21 AM
https://www.youtube.com/shorts/ytaFJfyo9N8
Eeshxn
Zyzz the God🔱
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macross89 18-Sep-22 10:21 AM
you develop permanent tolerance to certains levels of effects of molly ?
10:21
gen bussin
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Cast
Molly made me invincible
brothermanbill 18-Sep-22 10:21 AM
Last two times i did molly were terrible experiences weird (edited)
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veganpermanently 18-Sep-22 10:22 AM
the thing about psychopathy
10:22
if anyone realizes you're a psycho no one will like u anymore
10:22
then u can change towns and start all over
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Cast 18-Sep-22 10:22 AM
https://youtu.be/Re4oM4DzPrc
Our Hidden History
The Psychopath Machine: MKULTRA-linked Torture at Penetang Hospital...
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veganpermanently
if anyone realizes you're a psycho no one will like u anymore
brothermanbill 18-Sep-22 10:23 AM
Does oxytocin diminish toward psychopathy
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MEE6 BOT 18-Sep-22 10:23 AM
@brothermanbill, you have advanced to lvl 3 respect++ emoji_51
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brothermanbill
Last two times i did molly were terrible experiences weird (edited)
Cast 18-Sep-22 10:23 AM
Rip
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veganpermanently 18-Sep-22 10:23 AM
psychopathy is hell
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Cast 18-Sep-22 10:23 AM
Molly made me have infinite confidence and no regard for other people
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macross89 18-Sep-22 10:23 AM
wtf in ontario canada ?
10:23
shitttt
10:23
I live right next door
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veganpermanently 18-Sep-22 10:23 AM
to survive u have to pretend you're not a psychopath
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Cast
Molly made me have infinite confidence and no regard for other people
JK 18-Sep-22 10:23 AM
???
10:23
So reversed
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Cast 18-Sep-22 10:24 AM
Kicked peoole out, boasted about myself, pretended to know what i was talking about to seem smart. Easily talked to women
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veganpermanently 18-Sep-22 10:24 AM
and any time if it comes across anyone's mind to ask you about empathy you're done
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Cast 18-Sep-22 10:24 AM
Made me a psychopath temporarily it was nice (edited)
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Cast
Kicked peoole out, boasted about myself, pretended to know what i was talking about to seem smart. Easily talked to women
JK 18-Sep-22 10:24 AM
That’s… cocaine
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Cast
Kicked peoole out, boasted about myself, pretended to know what i was talking about to seem smart. Easily talked to women
macross89 18-Sep-22 10:24 AM
sounds like an asshole
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Cast 18-Sep-22 10:24 AM
Yea (edited)
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Cast
Kicked peoole out, boasted about myself, pretended to know what i was talking about to seem smart. Easily talked to women
veganpermanently 18-Sep-22 10:24 AM
no one liked you
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Cast
Kicked peoole out, boasted about myself, pretended to know what i was talking about to seem smart. Easily talked to women
brothermanbill 18-Sep-22 10:24 AM
Ahhahahahahh
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Cast 18-Sep-22 10:24 AM
U tend to do anti social things when ur under psychopathy
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JK 18-Sep-22 10:25 AM
I always get laid on cocaine
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veganpermanently 18-Sep-22 10:25 AM
you got nothing from it
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Cast 18-Sep-22 10:25 AM
No
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JK 18-Sep-22 10:25 AM
I can do anything
10:25
Which is why I have to not do it
10:25
..
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Cast 18-Sep-22 10:25 AM
I wasnt an asshole really i was more manipulative and dominant
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macross89 18-Sep-22 10:25 AM
Image attachment
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veganpermanently
then u can change towns and start all over
Netizenne 18-Sep-22 10:25 AM
Fast life history strategist -adapted to unstable ecologies.
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JK
I can do anything
veganpermanently 18-Sep-22 10:25 AM
every cokehead out there
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macross89 18-Sep-22 10:26 AM
what does cocaine feel like
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JK 18-Sep-22 10:26 AM
Yeah it’s a tragicomedy
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macross89 18-Sep-22 10:26 AM
what does it do for you
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JK 18-Sep-22 10:26 AM
Don’t do it lol
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veganpermanently 18-Sep-22 10:26 AM
https://www.youtube.com/watch?v=38hwk0BgGNU
Eternalised
The Psychology of The Trickster
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JK 18-Sep-22 10:26 AM
If u so call me first
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brothermanbill
Does oxytocin diminish toward psychopathy
Netizenne 18-Sep-22 10:26 AM
Probably considering they are fast life history strategists
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Cast 18-Sep-22 10:26 AM
Pov no one realized i was an asshole since it wss multiple small things on several different people
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MEE6 BOT 18-Sep-22 10:26 AM
@Cast, you have advanced to lvl 5 respect++ emoji_51
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macross89 18-Sep-22 10:26 AM
how does it compare to adderall ?
10:26
is it just a stimulant
10:26
or what
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JK 18-Sep-22 10:27 AM
What cocaine?
10:27
Or mdma
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macross89 18-Sep-22 10:27 AM
cocaine
10:27
to adderall
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JK 18-Sep-22 10:27 AM
They are both herbs
10:27
Adaptogens
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Netizenne 18-Sep-22 10:27 AM
Image attachment
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JK 18-Sep-22 10:27 AM
I thing cocaine is akin to adderal in some sense
10:28
Quicker onset
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Cast
Pov no one realized i was an asshole since it wss multiple small things on several different people
veganpermanently 18-Sep-22 10:28 AM
did u ask them
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macross89 18-Sep-22 10:28 AM
ok cause i felt nothing on adderall so it probably wont do much
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veganpermanently 18-Sep-22 10:28 AM
no one will tell you ure an asshole unless u ask
10:28
it's not in their self interest
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Cast 18-Sep-22 10:28 AM
Eh maybe they did but it feels so good that its worth it and youll get better at being s psychopath over time (edited)
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macross89 18-Sep-22 10:29 AM
you can only be an asshole if youre a chad
10:29
you have to be a certain height
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Cast
Eh maybe they did but it feels so good that its worth it and youll get better at being s psychopath over time (edited)
veganpermanently 18-Sep-22 10:29 AM
r u demented
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macross89 18-Sep-22 10:29 AM
like a giant
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Cast 18-Sep-22 10:29 AM
If i was in that state permanetly i would be highly manipulative and charismatic by now and i would probably have anything i want
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macross89
ok cause i felt nothing on adderall so it probably wont do much
brothermanbill 18-Sep-22 10:29 AM
Try zenzedi 50mg boofed you will be locked and loaded and ready to spurt split splat splotch a bunch of cream in the milk jug🥦
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macross89 18-Sep-22 10:29 AM
no
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Cast 18-Sep-22 10:30 AM
Actually
10:30
Whats interesting is psychopathy is thkught to be caused by excess serotonin as a fetus (edited)
10:30
And mdma is a powerful serotonin agonist
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ibtisam.midlet 18-Sep-22 10:30 AM
https://youtu.be/d6El5Tdjcwo
Zen - Kun
Nightcore - Psycho
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macross89 18-Sep-22 10:30 AM
ok maybe we need more ssris
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veganpermanently 18-Sep-22 10:30 AM
https://www.youtube.com/watch?v=38hwk0BgGNU
Eternalised
The Psychology of The Trickster
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Cast
Whats interesting is psychopathy is thkught to be caused by excess serotonin as a fetus (edited)
veganpermanently 18-Sep-22 10:31 AM
watch this
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macross89 18-Sep-22 10:31 AM
maybe I need to give up my sexual hunger for psychopathy
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veganpermanently 18-Sep-22 10:31 AM
@Netizenne u too
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veganpermanently
https://www.youtube.com/watch?v=38hwk0BgGNU
Cast 18-Sep-22 10:31 AM
What is it
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macross89 18-Sep-22 10:31 AM
zoloft perhaps
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Cast
What is it
veganpermanently 18-Sep-22 10:31 AM
it will provide a better archetype than psychopath
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macross89
maybe I need to give up my sexual hunger for psychopathy
Cast 18-Sep-22 10:31 AM
Psychopaths are sex fiends
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veganpermanently 18-Sep-22 10:31 AM
everyone will like u as a trickster
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macross89 18-Sep-22 10:31 AM
I feel like a psychopath wouldnt give a shit about sex
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MEE6 BOT 18-Sep-22 10:31 AM
@macross89, you have advanced to lvl 5 respect++ emoji_51
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veganpermanently 18-Sep-22 10:32 AM
because you will be fun to be around
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macross89 18-Sep-22 10:32 AM
like meaningless
10:32
and not fun for them really
10:32
they just do it to feel superior
10:32
but dont enjoy it prob
10:32
its not something theyre really after
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veganpermanently 18-Sep-22 10:32 AM
and those who don't like you will be despised by everyone else
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macross89 18-Sep-22 10:32 AM
they just want to control everything maybe
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Cast
Pov no one realized i was an asshole since it wss multiple small things on several different people
Netizenne 18-Sep-22 10:32 AM
Psychopathy is adapted for environments where people are coming and going lots, where there aren’t long lasting social structures you have to conform to. R-selection refers to the selective pressure to adapt to these unstable environments where things are always changing and unpredictable. Psychopathy, selfishness, and dark triad traits are all associated with it.
👍 1
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Netizenne
Psychopathy is adapted for environments where people are coming and going lots, where there aren’t long lasting social structures you have to conform to. R-selection refers to the selective pressure to adapt to these unstable environments where things are always changing and unpredictable. Psychopathy, selfishness, and dark triad traits are all associated with it.
Cast 18-Sep-22 10:32 AM
So nyc
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Netizenne 18-Sep-22 10:33 AM
Ya
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Cast 18-Sep-22 10:33 AM
I took lsd st nyc and i could feel the assimilation. I was far colder at the end
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Netizenne
Ya
macross89 18-Sep-22 10:33 AM
Image attachment
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macross89
I feel like a psychopath wouldnt give a shit about sex
veganpermanently 18-Sep-22 10:33 AM
Sex is disappointment for me
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Cast 18-Sep-22 10:33 AM
Always moving fast pushing others out of my way
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macross89
Click to see attachment 🖼️
Netizenne 18-Sep-22 10:33 AM
Fr
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macross89 18-Sep-22 10:33 AM
sex is boring
10:33
why are you guys always looking for sex
10:33
maybe tahts y u have problems
10:34
nah sex is good
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Cast
Whats interesting is psychopathy is thkught to be caused by excess serotonin as a fetus (edited)
brothermanbill 18-Sep-22 10:34 AM
L-tryptophan for mothers, along with tryptophan hydroxylase promotion with black seed oil, pinealon intranasal, thymogen intrnanasal, bpc-157. Also mk-677 does something to amagydala that causes ptsd-like behavior when taken longterm and alters serotonin brain metabolism
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Cast 18-Sep-22 10:34 AM
Marcoss stop projecting
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macross89 18-Sep-22 10:34 AM
i like sex
10:34
lol
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brothermanbill
L-tryptophan for mothers, along with tryptophan hydroxylase promotion with black seed oil, pinealon intranasal, thymogen intrnanasal, bpc-157. Also mk-677 does something to amagydala that causes ptsd-like behavior when taken longterm and alters serotonin brain metabolism
Cast 18-Sep-22 10:34 AM
Also maoa l genes
10:35
Psychopathy doesnt seem to hard to induce
10:35
Thr tricky part is to avoid side effects
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Netizenne 18-Sep-22 10:35 AM
Edward Dutton has a book called “The Genius Famine” where he discusses how the right mix of both r and K selected traits are needed to be a creative genius. I haven’t read it but I’ve read about it -and iirc a creative genius is an r-selected individual who comes from a K-selected population.
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Cast
Thr tricky part is to avoid side effects
brothermanbill 18-Sep-22 10:35 AM
Synesthesia side effects.
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Cast 18-Sep-22 10:36 AM
Molly will probably make u a psychopath with abuse but at the expense of cognitive function
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Netizenne
Edward Dutton has a book called “The Genius Famine” where he discusses how the right mix of both r and K selected traits are needed to be a creative genius. I haven’t read it but I’ve read about it -and iirc a creative genius is an r-selected individual who comes from a K-selected population.
Netizenne 18-Sep-22 10:36 AM
So the creative genius is genetically K selected while epigenetically r-selected I think
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Netizenne
Psychopathy is adapted for environments where people are coming and going lots, where there aren’t long lasting social structures you have to conform to. R-selection refers to the selective pressure to adapt to these unstable environments where things are always changing and unpredictable. Psychopathy, selfishness, and dark triad traits are all associated with it.
SorryIwasAway 18-Sep-22 10:36 AM
Is that why it’s highest in African population? Because large stable societies weren’t a thing
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SorryIwasAway
Is that why it’s highest in African population? Because large stable societies weren’t a thing
Netizenne 18-Sep-22 10:37 AM
They are the most r selected
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SorryIwasAway
Is that why it’s highest in African population? Because large stable societies weren’t a thing
veganpermanently 18-Sep-22 10:37 AM
so that's why my psychopath friend wants to travel Africa
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Netizenne 18-Sep-22 10:37 AM
Besides maybe seasians (edited)
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veganpermanently 18-Sep-22 10:37 AM
impreegnate bunch of melanistic bitches
10:38
because the chalky ones won't take his seed
despair 1
10:38
ayways
10:38
anyone used swisschems
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veganpermanently
so that's why my psychopath friend wants to travel Africa
judas 18-Sep-22 10:39 AM
Depends what part of Africa. I would assume a place like Nigeria is K-selected
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macross89 18-Sep-22 10:40 AM
why does google describe mollys effects as increased empathy
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Cast 18-Sep-22 10:40 AM
Because serotonin lol
10:40
For some reason it does the opposite for me
10:40
It just acts like meth
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macross89 18-Sep-22 10:41 AM
is it ?
10:41
3,4-Methyl​enedioxy​methamphetamine (edited)
10:41
😐
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Cast 18-Sep-22 10:41 AM
Yea
10:41
I think idk
10:42
Mdma
10:42
4 words
10:42
Meth dioxy meth amphetamine
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macross89
why does google describe mollys effects as increased empathy
Cast 18-Sep-22 10:43 AM
Molly will probably make u less psychopathic acutely if u arent like me
10:44
I need to tske ig again
10:45
https://youtu.be/YYyEkXu_76g
The Means of Seduction
SEDUCE WITH YOUR EYES: A Lesson in Hypnosis & Eye Contact | The Mea...
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macross89 18-Sep-22 10:46 AM
gay
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Cast 18-Sep-22 10:46 AM
Dark psych bro
10:46
Psychopathy is just the mindset u need the tools
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judas
Depends what part of Africa. I would assume a place like Nigeria is K-selected
Netizenne 18-Sep-22 10:50 AM
Why so?
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macross89
is it ?
veganpermanently 18-Sep-22 10:51 AM
same MoA. Adderal too
10:51
find me a way to embody the trickster
10:52
I did it before with harmalas, nicotine and psilocin
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Cast 18-Sep-22 10:52 AM
https://www.instagram.com/reel/CiBBzYNA5ru/?igshid=MTA0ZTI1NzA=
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Cast
https://www.instagram.com/reel/CiBBzYNA5ru/?igshid=MTA0ZTI1NzA=
Cast 18-Sep-22 10:53 AM
This comes naturally to psychopaths
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veganpermanently 18-Sep-22 10:53 AM
ew instagram
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Cast 18-Sep-22 10:53 AM
This page is based
10:53
Its a bunch of charisma and dark psych tips
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veganpermanently 18-Sep-22 10:54 AM
u r obsessed
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Cast 18-Sep-22 10:54 AM
Yea
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veganpermanently 18-Sep-22 10:54 AM
same as your IQ obsession before
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Cast 18-Sep-22 10:54 AM
Its my adhd
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veganpermanently 18-Sep-22 10:54 AM
nah it's pure O
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Cast 18-Sep-22 10:54 AM
I get obsessed with some shit randomly its all i care about for weeks (edited)
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veganpermanently
nah it's pure O
Yana 18-Sep-22 10:55 AM
I thought you wanted to burn the DSM to the ground
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Yana
I thought you wanted to burn the DSM to the ground
veganpermanently 18-Sep-22 10:55 AM
I didn't try to signal that here
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Yana 18-Sep-22 10:55 AM
Meme diagnosis just for someone obsessed with things
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veganpermanently 18-Sep-22 10:56 AM
obsession is a pattern not a diagnosis
10:57
perhaps the simplest pattern of neurotransmission
10:57
or so it seems
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Cast
I get obsessed with some shit randomly its all i care about for weeks (edited)
CEO 18-Sep-22 10:59 AM
Happens to me a lot
10:59
Pretty sure it’s Pure O
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Cast 18-Sep-22 11:01 AM
Wtf is pure o
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Cast
I get obsessed with some shit randomly its all i care about for weeks (edited)
Netizenne 18-Sep-22 11:01 AM
Honestly the way to go about things tho
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macross89 18-Sep-22 11:01 AM
ok how good is nitocint
11:01
nicotine
11:01
like fuck that burning in haling shit
11:01
but theres other ways
11:01
patch and spray
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Cast 18-Sep-22 11:01 AM
I think ill just mk ultra myself by taking lsd in public
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Cast
Wtf is pure o
Netizenne 18-Sep-22 11:02 AM
ocd subtype Pure obsession
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macross89
like fuck that burning in haling shit
veganpermanently 18-Sep-22 11:02 AM
in my experience intranasal was best
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Cast
I think ill just mk ultra myself by taking lsd in public
veganpermanently 18-Sep-22 11:02 AM
did that
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Cast 18-Sep-22 11:02 AM
My fear is being antagonized on lsd could turn me into a pussy instead of a psychopath
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Cast
I think ill just mk ultra myself by taking lsd in public
veganpermanently 18-Sep-22 11:02 AM
whatever u think of I already tried emoji_52
11:03
trickster is always one step ahead of you
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Cast 18-Sep-22 11:03 AM
Have u tried
11:03
Starvation?
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veganpermanently 18-Sep-22 11:03 AM
yes
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Netizenne 18-Sep-22 11:03 AM
We’ve all gone through a phase of trying to use psyches to induce lasting synesthesia I bet (edited)
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Cast 18-Sep-22 11:03 AM
Phase?
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veganpermanently 18-Sep-22 11:03 AM
lol
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Cast 18-Sep-22 11:03 AM
U think im done with that?
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veganpermanently 18-Sep-22 11:03 AM
I often forget about how much experience I have
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veganpermanently
I often forget about how much experience I have
Netizenne 18-Sep-22 11:04 AM
So wise Greek statue man!!!!!!!!
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Cast 18-Sep-22 11:04 AM
I never forget my obsessions they just go on standby
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Cast
I never forget my obsessions they just go on standby
Netizenne 18-Sep-22 11:04 AM
Ideally they even build on top of eachother
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Cast 18-Sep-22 11:05 AM
They do for me
11:05
Everything is constantly building
11:06
I just need better tools
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Netizenne
Why so?
judas 18-Sep-22 11:06 AM
The contrast in culture. You’ll understand if you ever interact with Nigerians
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Cast 18-Sep-22 11:06 AM
I wish i could get brain surgery for whatever i wanted
11:07
I would have them nuke my orbital cortex and amygdala. Then i would get high IQ stem cell injections into my parietal cortex and my hippocampus
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macross89 18-Sep-22 11:07 AM
I'm going to try D-Serine eventually
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Cast 18-Sep-22 11:07 AM
Then after a bit of recovery id be a 150 IQ psychopathic
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macross89
I'm going to try D-Serine eventually
Cast 18-Sep-22 11:08 AM
For fear extinction?
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Cast
This comes naturally to psychopaths
judas 18-Sep-22 11:08 AM
You should befriend one it’ll help demystify them so you can make more accurate judgements about them
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macross89 18-Sep-22 11:08 AM
I'm now working at a museum of war and a museum of history
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MEE6 BOT 18-Sep-22 11:08 AM
@judas, you have advanced to lvl 2 respect++ emoji_51
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macross89 18-Sep-22 11:08 AM
basically set up events inside
11:08
we have one of hitlers cars in our museum of war
11:08
lol
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judas
You should befriend one it’ll help demystify them so you can make more accurate judgements about them
Cast 18-Sep-22 11:08 AM
No
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macross89 18-Sep-22 11:08 AM
yeah fear extinction
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Cast 18-Sep-22 11:08 AM
I already know two psychopaths
11:08
I dont talk to them
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macross89 18-Sep-22 11:08 AM
if you don't fear anything then maybe thats all we need
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Cast 18-Sep-22 11:09 AM
No
11:09
U wont fear failure
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macross89 18-Sep-22 11:09 AM
isn't emotions regulated by fear
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Cast 18-Sep-22 11:09 AM
U wont fear becoming a loser
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Cast
I dont talk to them
judas 18-Sep-22 11:09 AM
They’re not that scary
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macross89 18-Sep-22 11:09 AM
so if you don't fear your free from its clutches
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judas
They’re not that scary
Cast 18-Sep-22 11:09 AM
They arent trustworthy
11:09
The one i know is a pathological liar
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macross89 18-Sep-22 11:09 AM
holy shit
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Cast 18-Sep-22 11:10 AM
Makes up pettylies
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Cast
They arent trustworthy
judas 18-Sep-22 11:10 AM
They won’t try you as much if they don’t think you’re gullible
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veganpermanently 18-Sep-22 11:11 AM
Image attachment
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Cast
The one i know is a pathological liar
judas 18-Sep-22 11:11 AM
I was a pathological liar at one point when I was younger so ig I’m just more attuned to interacting with them.
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macross89 18-Sep-22 11:11 AM
I feel like if I can't at least walk on the treadmill for like 9 hours then I'm probably unhealthy as fuck
11:11
like its just walking
11:12
maybe on weekends I need to walk on treadmill for 4 or 5 hours
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judas 18-Sep-22 11:12 AM
Walking in one spot for 9 hours sounds like just an autistic way to get your cardio in
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Cast
I wish i could get brain surgery for whatever i wanted
Netizenne 18-Sep-22 11:12 AM
Imo I think we have to take diy biohacking to the next level eventually and venture from more than just psychiatry Diy home brain surgery is the next frontier in biohacking just you wait
Eyespop 1
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macross89 18-Sep-22 11:13 AM
yeah but if I run for 1 hour then I sit/lie down for 23 hours I feel like thats super unhealthy
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judas
I was a pathological liar at one point when I was younger so ig I’m just more attuned to interacting with them.
Cast 18-Sep-22 11:13 AM
Ig but im not getring close to soemone who would toss me aside at a moments notice
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Netizenne 18-Sep-22 11:13 AM
Gonna start with trepanations (edited)
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Cast
Ig but im not getring close to soemone who would toss me aside at a moments notice
judas 18-Sep-22 11:14 AM
You make them co-dependent on you and not the other way around but it has to be done carefully (edited)
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Netizenne
Imo I think we have to take diy biohacking to the next level eventually and venture from more than just psychiatry Diy home brain surgery is the next frontier in biohacking just you wait
Cast 18-Sep-22 11:14 AM
If u had a sterile wire to penetrate the skull and knew where the blood vessels were
11:14
You know whats funny
11:14
My mom thought i was a psychopath
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Cast
U wont fear failure
Netizenne 18-Sep-22 11:15 AM
Maybe all you need is desire
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Cast 18-Sep-22 11:15 AM
She accused me of having no emotions and constantly tested me
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Original message was deleted or could not be loaded.
veganpermanently 18-Sep-22 11:15 AM
all of my three bitches liked this picture
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macross89 18-Sep-22 11:16 AM
I think youre obssesed with psychopathy
11:16
are you sure its what you're looking for
11:16
or maybe you have some kind of underlying issue
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Cast 18-Sep-22 11:16 AM
Yes
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MEE6 BOT 18-Sep-22 11:16 AM
@Cast, you have advanced to lvl 6 respect++ emoji_51
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Cast 18-Sep-22 11:16 AM
Everything is clicking
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macross89 18-Sep-22 11:16 AM
maybe you don't love yourself and tahts why youre always looking to be something else
Eyespop 1
11:16
😐
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Cast 18-Sep-22 11:17 AM
No
11:17
I want power
11:17
And control (edited)
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macross89 18-Sep-22 11:17 AM
You could say I'm projecting hahaha but I do realize that I'm like that
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veganpermanently 18-Sep-22 11:17 AM
let's psychologize him
11:18
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Cast 18-Sep-22 11:18 AM
Ur pseudo projecting
11:18
Understanding ur ownself by projecting on to others
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veganpermanently 18-Sep-22 11:19 AM
needless psychologization
11:19
none of u are responsible adults
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Cast 18-Sep-22 11:20 AM
True
11:20
Yea so d serine goes on my checklist
11:21
Agmantine perhaps
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macross89 18-Sep-22 11:21 AM
agmatine is a must for me
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Cast 18-Sep-22 11:21 AM
Also ive heard things about ashwaganda
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macross89 18-Sep-22 11:21 AM
cause apparently it reduces the tolerance to drugs
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Cast
Also ive heard things about ashwaganda
veganpermanently 18-Sep-22 11:21 AM
limp dick tomato
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MEE6 BOT 18-Sep-22 11:21 AM
@veganpermanently, you have advanced to lvl 15 respect++ emoji_51
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Cast 18-Sep-22 11:22 AM
The rough stack so far: Agmantine Ashwaganda D serine Stims
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veganpermanently
limp dick tomato
Cast 18-Sep-22 11:22 AM
?
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macross89 18-Sep-22 11:22 AM
my current stack is not much
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veganpermanently 18-Sep-22 11:23 AM
I'll try replacing caffeine with moda tomorrow
11:23
never tried that
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macross89 18-Sep-22 11:23 AM
I just use agmatine, bromantane w/ alcar, omega3, modafinil, idra-21, montelukast
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veganpermanently 18-Sep-22 11:23 AM
that was the reason I bought moda in the first place lol
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macross89 18-Sep-22 11:24 AM
and vit d3
11:24
what I need is a multi mineral and vitamine which I found earlier today
11:24
its not expensive
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Cast 18-Sep-22 11:24 AM
U prob need hard drugs
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macross89 18-Sep-22 11:24 AM
and I take skq1 when I have it
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Cast 18-Sep-22 11:24 AM
Nootropics are just nootropics
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macross89 18-Sep-22 11:24 AM
then I want to reincorporate NAC
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Cast 18-Sep-22 11:25 AM
U need something stronger to permanetly alter yourself
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macross89 18-Sep-22 11:25 AM
and meditate and exercise
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Cast
U prob need hard drugs
veganpermanently 18-Sep-22 11:25 AM
I swear you suddenly became demented from something
💀 1
11:25
or degenerate
11:25
or retarded
11:25
or everything
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macross89 18-Sep-22 11:25 AM
probablu
11:25
ahha
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Cast 18-Sep-22 11:25 AM
I did
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macross89 18-Sep-22 11:26 AM
I also take phenibut now
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Cast 18-Sep-22 11:26 AM
The day after i took molly
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macross89 18-Sep-22 11:26 AM
but i cant tell if its doing anything
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Cast 18-Sep-22 11:26 AM
I went psychotic and was convinced my friends betrayed me
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macross89 18-Sep-22 11:26 AM
I think what you need is therapy with a psychologist lol
11:26
I used to be like you
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Cast 18-Sep-22 11:26 AM
No
11:27
This is part of the process
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veganpermanently 18-Sep-22 11:27 AM
nah boy needs to clean up
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Cast 18-Sep-22 11:27 AM
I need to exist in pain to be enlightened
11:27
Watch tokyo ghoul first season
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macross89 18-Sep-22 11:27 AM
ice cold showers perhaps
11:27
oh no
11:27
you watch anime
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Cast 18-Sep-22 11:27 AM
Im essentially kaneki being tortured
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macross89
ice cold showers perhaps
veganpermanently 18-Sep-22 11:27 AM
yeah and a run
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macross89 18-Sep-22 11:27 AM
975870265147940914
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veganpermanently 18-Sep-22 11:27 AM
also don't be a weeb
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macross89 18-Sep-22 11:28 AM
dont watch anime
11:28
or tv in general
11:28
cringe
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Cast 18-Sep-22 11:28 AM
Thats gay mindset
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macross89 18-Sep-22 11:28 AM
😐
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Cast
Thats gay mindset
veganpermanently 18-Sep-22 11:28 AM
did u just say not watching anime is gay
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Cast 18-Sep-22 11:28 AM
No
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macross89 18-Sep-22 11:28 AM
also don't look at social media
11:28
it will make u gay
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Cast 18-Sep-22 11:28 AM
Thinking anime is gay is gay
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macross89 18-Sep-22 11:29 AM
no I dont think its gay
11:29
it will make you gay
emoji_52 1
11:29
emoji_50
11:31
I also want to incorporate metformin into my stack
11:31
once every two days
11:31
I already have my beauty stack set
11:31
just gay stuff like
11:33
sunscreen, glycolic acid, ceramides lotion, tretinoin 0.25%, green tea toner, green tea serum, mitovitan SKQ1 serum, hyaluronic acid oral supplement with low molecular weight
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veganpermanently
yeah and a run
Netizenne 18-Sep-22 11:33 AM
Or nice long hot bath perhaps even!!!
11:34
I might try hot baths more
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macross89 18-Sep-22 11:34 AM
hot baths make me lazy and kill my skin
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Netizenne 18-Sep-22 11:34 AM
hmm
11:34
I need my skin
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macross89
sunscreen, glycolic acid, ceramides lotion, tretinoin 0.25%, green tea toner, green tea serum, mitovitan SKQ1 serum, hyaluronic acid oral supplement with low molecular weight
judas 18-Sep-22 11:35 AM
Link for the Trentinoin?
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macross89
no I dont think its gay
Cast 18-Sep-22 11:35 AM
Tokyo ghoul will change ur mindset
🏳️‍🌈 1
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macross89 18-Sep-22 11:36 AM
mine is prescription from online pharmacy in my country
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Cast 18-Sep-22 11:36 AM
Its part of the reason i discovered the importance of psychopathy
11:36
Mc was a beta male that got tortured into a psychopathic chad
11:36
Finger nails ripped off
11:37
Centipede inserted into his ear
11:37
He had to choose between a couple being executed (edited)
11:38
He was too beta to choose so the instigator killed them both
11:38
He learned the hardway
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macross89 18-Sep-22 11:39 AM
damn bro
11:39
bro not gonna lie
11:40
you need therapy and to change your mentality lol
11:40
like your outlook
11:40
and the way you see things
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Cast 18-Sep-22 11:40 AM
Thought u were gonna say it sounded metal
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macross89 18-Sep-22 11:40 AM
like the whole beta alpha stuff
11:40
well yeah it is metal
11:40
but like
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Cast 18-Sep-22 11:40 AM
I dont actually believe in that shit
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macross89 18-Sep-22 11:40 AM
the beta alpha stuff is like, cringe social media crap that turns people into cucks
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Cast 18-Sep-22 11:40 AM
Its just easier to say beta than submissive
11:41
Beta. Pussy submissive
11:41
Its all the same
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macross89 18-Sep-22 11:41 AM
just don't get too entangled in that stuff imo
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Cast 18-Sep-22 11:41 AM
I dint believe in actual archetypes
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macross89 18-Sep-22 11:41 AM
975870265147940914
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MEE6 BOT 18-Sep-22 11:41 AM
@macross89, you have advanced to lvl 6 respect++ emoji_51
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Cast 18-Sep-22 11:41 AM
Thats a fixed mindset
11:41
Humans are complex and fluid (edited)
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macross89
just don't get too entangled in that stuff imo
Cast 18-Sep-22 11:42 AM
But more importantly dont detract from the original intent of my message
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Cast
Tokyo ghoul will change ur mindset
Yana 18-Sep-22 11:42 AM
I have a gay friend and this is one of his favorite anime
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Cast 18-Sep-22 11:42 AM
Which is that u need to develop a killer instinct
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Yana
I have a gay friend and this is one of his favorite anime
Cast 18-Sep-22 11:43 AM
Autistic fixation
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macross89 18-Sep-22 11:43 AM
anytime I think of people with that focus on alpha beta mentality I think of people with low self esteem that probably end up abusing anabolics, party drugs and alwasy try to look for attention and end up a huge fucking mess and probably dying or dying early and plenty of diseases
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Cast 18-Sep-22 11:43 AM
Certain subtypes of media appeal to autists/queers but it doesnt mean u cant gst value out of it
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macross89
anytime I think of people with that focus on alpha beta mentality I think of people with low self esteem that probably end up abusing anabolics, party drugs and alwasy try to look for attention and end up a huge fucking mess and probably dying or dying early and plenty of diseases
Cast 18-Sep-22 11:43 AM
No retard
11:44
Ignore the beta alpha shit
11:44
Just watch tokyo ghoul first season
11:44
And really adopt the kill or be killed theme it protrays
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veganpermanently
or everything
Yana 18-Sep-22 11:44 AM
Lmao
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Yana
Lmao
Cast 18-Sep-22 11:47 AM
Have u tried tak yana
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Yana 18-Sep-22 11:48 AM
Yeah
11:48
The first 2 times I took it (4mg) it was dissociative but after cumulative use it feels more like NSI almost
11:49
Just clean, diffuse BDNF-like glowing
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Cast 18-Sep-22 11:49 AM
Do any cog testing?
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Yana 18-Sep-22 11:50 AM
I took 2 IQ tests and they both ended up being capped at like 125 but I'm not sure if I was smarter
11:50
The dissociation is bourne of a kind of skepticism in your thoughts/actions
11:50
Basically I think it took a lot more WM than usual to verify the answer I chose was correct
11:50
Typical results on HB
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Cast 18-Sep-22 11:50 AM
So it was anti nootropic?
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Yana 18-Sep-22 11:51 AM
And I got like 138 on symbol search and it was the most insane 2 minutes ever but I've never taken it before
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Cast
So it was anti nootropic?
Yana 18-Sep-22 11:51 AM
Overall probably not. I'll have to give it more time
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Cast 18-Sep-22 11:51 AM
I get like 142 on sym search
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Yana 18-Sep-22 11:51 AM
In the studies benefits lasted past the half life so I may need to hop off for a few days
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Yana
Overall probably not. I'll have to give it more time
Cast 18-Sep-22 11:52 AM
Seems like a far cry from what sirsad boasted
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Yana 18-Sep-22 11:52 AM
It definitely feels different subjectively than what everyone expected
11:53
Well ig besides sirsad himself
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Cast 18-Sep-22 11:53 AM
I never had faith in it amplifying anything other than procedual memory
11:53
Since thats what ampa pams are notorious for doing
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Yana 18-Sep-22 11:53 AM
I'll have to play around with it more but the first 2 or 3 days I noted impaired lateral thinking for sure
11:54
Made it very hard to go between different schemas
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Cast 18-Sep-22 11:54 AM
Odd
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Yana 18-Sep-22 11:54 AM
Mood boosting though for sure
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Cast 18-Sep-22 11:54 AM
Im dissapointed
11:55
Despite my skepticism actually wanted it to work
11:55
To literally increase working memory as sirsad said
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Netizenne
I might try hot baths more
veganpermanently 18-Sep-22 11:55 AM
bath is so 18th century
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Yana 18-Sep-22 11:56 AM
Yeah it's for sure more for procedural memory
11:56
You might like it though
11:56
Not sure it touches wm
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Cast 18-Sep-22 11:56 AM
For typing (edited)
11:56
I told sirsad thats what it would do lol
11:56
Ampa pams arent the right place to look
11:56
Or pretty much any existing pathway in common noots (edited)
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Yana 18-Sep-22 11:57 AM
I didn't know about this aspect of ampa
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Cast 18-Sep-22 11:57 AM
What aspect?
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Yana 18-Sep-22 11:57 AM
That it is primarily for procedural
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Cast 18-Sep-22 11:57 AM
Ah
11:57
I knew because idra 21 was my first nootropic
11:57
Which was all the craze a year ago
11:58
Turned out to not be helpful with intellectual pursuits but rather motor skills lol
👍 1
11:58
People thought it would increase wm
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veganpermanently 18-Sep-22 11:59 AM
@Netizenne I'm addicted to hot showers as fast as winter arrives. I guess my circulation is fucked unless I bike for 10 hours in a day
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Cast 18-Sep-22 11:59 AM
Also sirsads tables arent conclusive at all
12:00
U can get increases like that from placebo and training effect
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veganpermanently 18-Sep-22 12:00 PM
bromantane.co scam
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veganpermanently
@Netizenne I'm addicted to hot showers as fast as winter arrives. I guess my circulation is fucked unless I bike for 10 hours in a day
Netizenne 18-Sep-22 12:01 PM
How cold does it get there, can you bike in the winter?
12:01
The temp dropped here pretty suddenly and biking became pretty chilly
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Netizenne
How cold does it get there, can you bike in the winter?
veganpermanently 18-Sep-22 12:02 PM
I can't solely because I get nasal problems very quickly
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veganpermanently
I can't solely because I get nasal problems very quickly
Netizenne 18-Sep-22 12:04 PM
Ah rip I might get that issue too
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Netizenne
How cold does it get there, can you bike in the winter?
Yana 18-Sep-22 12:04 PM
It's not too bad down there in Adelaide
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Yana
It's not too bad down there in Adelaide
Netizenne 18-Sep-22 12:05 PM
Your Australian?????????????
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Netizenne
Your Australian?????????????
Yana 18-Sep-22 12:05 PM
Nah he is
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Yana
Nah he is
veganpermanently 18-Sep-22 12:05 PM
lel wut
12:05
is that a meme
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Yana 18-Sep-22 12:05 PM
@veganpermanently's youtube account is durianrider
😯 1
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veganpermanently 18-Sep-22 12:05 PM
Croatian in Australia
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Yana
@veganpermanently's youtube account is durianrider
veganpermanently 18-Sep-22 12:06 PM
do u know those videos with the hydration chart and sexy voice explaining it
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veganpermanently
do u know those videos with the hydration chart and sexy voice explaining it
Yana 18-Sep-22 12:07 PM
Nope
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veganpermanently 18-Sep-22 12:08 PM
https://www.youtube.com/watch?v=JzA5xcHinWw
durianrider
Weight Loss FACTS - How Water Helps You Burn MORE Fat
12:08
he started taking TRT and aged 20 years in a year
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Cast 18-Sep-22 12:11 PM
Wtf
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ibtisam.midlet 18-Sep-22 12:11 PM
click boobs emoji_1
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veganpermanently
he started taking TRT and aged 20 years in a year
Yana 18-Sep-22 12:12 PM
Classic
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veganpermanently
bromantane.co scam
JK 18-Sep-22 12:21 PM
Wdym?
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JK
Wdym?
veganpermanently 18-Sep-22 12:22 PM
someone should do rouge testing
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JK 18-Sep-22 12:23 PM
I think you could ask for his third-party lab results
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veganpermanently
Croatian in Australia
CEO 18-Sep-22 12:55 PM
Damn I know a Croatian from New Zealand in another server
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JK
Anyone has any idea, on why my veins intermittently narrow then bp rises, I start to experience confusion/stress and on top it makes all my muscles swell/tense up at least 1-2 cm (edited)
𝔘𝔵𝔨ü𝔩𝔩 18-Sep-22 01:19 PM
Try horse chestnut maybe, did you get the covid vaxx?
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JK
High dose k2?
𝔘𝔵𝔨ü𝔩𝔩 18-Sep-22 01:20 PM
Definitely not Vit. K if you have blood flow issues.
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𝔘𝔵𝔨ü𝔩𝔩
Try horse chestnut maybe, did you get the covid vaxx?
JK 18-Sep-22 01:22 PM
Nah, I tried two doses of k7 today, and felt like my head was going to explode. Will, look into what you recommended above. And no, I didn’t get it. I might have contracted Covid at some point, but no noticeable symptoms
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macross89
how are their brains wired, can we hack out brains to become psychopaths or what
𝔘𝔵𝔨ü𝔩𝔩 18-Sep-22 01:23 PM
You dont want that, they may not be depressed but they can never be happy.
emoji_52 1
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MEE6 BOT 18-Sep-22 01:23 PM
@𝔘𝔵𝔨ü𝔩𝔩, you have advanced to lvl 2 respect++ emoji_51
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macross89
no my brain is already hyperdopaminergic probably
𝔘𝔵𝔨ü𝔩𝔩 18-Sep-22 01:25 PM
Prob not, chronic cannabis use causes down-regulation and dysregulation of the dopaminergic system, especially in the striatum and pfc.
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macross89 18-Sep-22 01:25 PM
fuck I scored 28 on this
13:25
https://www.biotune.org/2021/04/yale-brown-ocd-self-rating-scale-y-bocs.html
yale-brown OCD self-rating scale (Y-BOCS)
try automatically calculate your score in yale brown ocd scale
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13:26
now im going to make a sandwhich
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macross89
but then I fell back down once my shifts got changed back to night shifts on weekends and had to work with asshole and assholes came to job place cause casino is right next door
𝔘𝔵𝔨ü𝔩𝔩 18-Sep-22 01:28 PM
Find a different job then and get back on the wagon. RC benzos are not the solution by any means.
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macross89
no it damages the intestinal lining or something
𝔘𝔵𝔨ü𝔩𝔩 18-Sep-22 01:29 PM
Liver
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JK
Nah, I tried two doses of k7 today, and felt like my head was going to explode. Will, look into what you recommended above. And no, I didn’t get it. I might have contracted Covid at some point, but no noticeable symptoms
𝔘𝔵𝔨ü𝔩𝔩 18-Sep-22 01:37 PM
Avoid supplemental K and high K foods. You probably have clotting issues. Get WWB and/or Ginkgo.
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JK 18-Sep-22 01:43 PM
That kinda scares me. I’ve been dealing with it for 3 years going from one doc to another, hospital more times than I can recall. Tried just about every supplement (except wwb, and blood thinners etc.) How would a doc go by testing for this? I need a bulletproof answer for my symptoms, and I want to know if I have any clots that might travel. I know I’m throwing questions at you here, but will supplementing with what you recommended, actually solve it, or just keep it at bay?
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𝔘𝔵𝔨ü𝔩𝔩
Avoid supplemental K and high K foods. You probably have clotting issues. Get WWB and/or Ginkgo.
veganpermanently 18-Sep-22 01:43 PM
avoid K vitamin for suspected clotting issues?
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macross89 18-Sep-22 01:44 PM
damn im reading this and so far its good
13:44
https://www.reddit.com/r/getting_over_it/comments/4sdzxi/rumination_101/
r/getting_over_it - Rumination 101
99 votes and 4 comments so far on Reddit
13:44
I need an anti rumination pathway drug
13:44
🤣
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veganpermanently
avoid K vitamin for suspected clotting issues?
𝔘𝔵𝔨ü𝔩𝔩 18-Sep-22 01:45 PM
Yeah, high dietary K gives me clotting issues personally.
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𝔘𝔵𝔨ü𝔩𝔩
Yeah, high dietary K gives me clotting issues personally.
veganpermanently 18-Sep-22 01:45 PM
like kale?
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macross89
https://www.reddit.com/r/getting_over_it/comments/4sdzxi/rumination_101/
macross89 18-Sep-22 01:47 PM
@Cast "over active amygdala" emoji_52
13:48
@𝔘𝔵𝔨ü𝔩𝔩 can D-serine help with over active amygdala ?
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macross89
@𝔘𝔵𝔨ü𝔩𝔩 can D-serine help with over active amygdala ?
veganpermanently 18-Sep-22 01:49 PM
Taurine, L theanine megadose
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macross89 18-Sep-22 01:50 PM
so you mean things that affect GABA
13:50
like benzos
13:50
emoji_50
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veganpermanently 18-Sep-22 01:50 PM
gram amounts of l theanine
13:50
no benzos suck
13:50
l theanine is not a GABAergic
13:51
and taurine is but it's much more nuanced than that
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veganpermanently
like kale?
𝔘𝔵𝔨ü𝔩𝔩 18-Sep-22 01:51 PM
Yeah most leafy greens. Brocolli, Brussel sprouts in excess. Anything high in K. Especially if Vit. E intake is low, they act antagonistcally, Vit. E thins, K clots.
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veganpermanently 18-Sep-22 01:53 PM
L Theanine + Memantine + Meditation
13:53
I should get on that train again
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macross89
@Cast "over active amygdala" emoji_52
Cast 18-Sep-22 02:35 PM
Ripski
14:35
Ur the opposite of a psychopath with negative charisma
14:35
And im a schizoid autist
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Pax1l 18-Sep-22 02:39 PM
Have you tried going outside
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Pax1l
Have you tried going outside
Cast 18-Sep-22 02:48 PM
Ur one to talk
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MEE6 BOT 18-Sep-22 02:48 PM
@Cast, you have advanced to lvl 7 respect++ emoji_51
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JK 18-Sep-22 02:48 PM
Don’t leave home
14:48
It’s a trap
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Cast 18-Sep-22 02:48 PM
Hows the cb3 peptide going pax?
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macross89 18-Sep-22 02:49 PM
@Cast is this what you're talking about ?https://www.reddit.com/r/science/comments/63kuuw/lsd_reduces_activity_in_the_amygdala_the_region/
r/science - LSD reduces activity in the amygdala, the region of the...
3,740 votes and 186 comments so far on Reddit
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macross89
@Cast is this what you're talking about ?https://www.reddit.com/r/science/comments/63kuuw/lsd_reduces_activity_in_the_amygdala_the_region/
Cast 18-Sep-22 02:49 PM
I had no idea
14:50
I was going off anecdotal evidence
14:50
From my own personal experience
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macross89 18-Sep-22 02:50 PM
yeah but if you read the comments there's a lot of questioning
14:50
as usual
14:50
which is good
14:51
Image attachment
14:51
like this
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JK 18-Sep-22 02:51 PM
So microdose lsd, d-serine, nsi = functional psychopathy?
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macross89 18-Sep-22 02:52 PM
I dont know
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JK 18-Sep-22 02:52 PM
I just want to see Jukesta succeed
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macross89 18-Sep-22 02:53 PM
there's also another thing that I read about GABA that's interesting
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JK 18-Sep-22 02:53 PM
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macross89 18-Sep-22 02:53 PM
https://www.reddit.com/r/science/comments/7aj2q8/comment/dpag3qw/?utm_source=share&utm_medium=web2x&context=3
r/science - Comment by u/Mehofjack on ”Scientists find key to unwan...
37,625 votes and 1,481 comments so far on Reddit
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14:53
I was just looking for things about intrusive thoughts
14:55
So it seems like people with autoimmune disorders would definitely have issues with anxiety
14:55
which I think I do
14:56
So LSD is interesting, anyone already know a lot about it ?
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macross89
https://www.reddit.com/r/science/comments/7aj2q8/comment/dpag3qw/?utm_source=share&utm_medium=web2x&context=3
JK 18-Sep-22 02:56 PM
Cool, but no conclusions as to how one would go about long term upregulation
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MEE6 BOT 18-Sep-22 02:56 PM
@JK, you have advanced to lvl 5 respect++ emoji_51
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macross89 18-Sep-22 02:57 PM
yeah well, at least for me, if I can control my autoimmune disorder maybe with LDN then I could have a lot less issues
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JK 18-Sep-22 02:57 PM
I’m not against gabergic compounds, but not necessarily for them either
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macross89 18-Sep-22 02:57 PM
Have you tried LSD microdoses ?
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JK 18-Sep-22 02:57 PM
LDN is fascinating
14:58
No only hella macro doses of psilocybin
14:58
Would like to try ssri microdose and lad in the future
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macross89 18-Sep-22 02:58 PM
fascinatingly expensive 975870265147940914
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JK 18-Sep-22 02:58 PM
Lsd*
14:59
Yeah so I’ve seen, but if recall russpharma was pretty cheap?
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macross89 18-Sep-22 02:59 PM
is LDN basically psilocin from the mushrooms or is it something else ?
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JK 18-Sep-22 02:59 PM
Or I might be mistaken
14:59
No idea
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JK
So microdose lsd, d-serine, nsi = functional psychopathy?
Cast 18-Sep-22 03:00 PM
Doubt
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macross89 18-Sep-22 03:00 PM
"LSD (lysergic acid diethylamide) is a synthetic chemical, made from a substance found in ergot, which is a fungus that infects rye (grain)."
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Cast 18-Sep-22 03:01 PM
Its not simple
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macross89 18-Sep-22 03:01 PM
what is so different about someones brain who is truly a psychopath
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Cast 18-Sep-22 03:01 PM
The reason i said lsd made me psychopathic wss the context
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macross89
what is so different about someones brain who is truly a psychopath
Cast 18-Sep-22 03:01 PM
Damage to orbital cortex and amygdala
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macross89 18-Sep-22 03:02 PM
oh
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Cast 18-Sep-22 03:02 PM
Lsd wont make u psychopathic. Being tortured on lsd might
15:02
Which is what mk ultra was
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macross89 18-Sep-22 03:02 PM
"When the amygdala is damaged, previously threatening stimuli come to be treated as benign. The classic discovery was that monkeys with amygdala damage were “tamed;” snakes, for example, no longer elicited so-called fight-flight responses after amygdala damage. Later studies in rats by me, and others, mapped out the amygdala’s role in a neural system that detects and responds to threats, and similar circuits were found to be operative when the human brain processes threats."
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Cast 18-Sep-22 03:02 PM
Also psychopathy isnt an accident
15:03
So u cant easily describe it as damage
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macross89 18-Sep-22 03:03 PM
so fight or flight ?
15:03
maybe focus on that
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macross89
what is so different about someones brain who is truly a psychopath
JK 18-Sep-22 03:03 PM
Gene expression
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Cast 18-Sep-22 03:03 PM
Its a purposeful trait emerging from evolution
15:03
Not a malfunction
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JK 18-Sep-22 03:03 PM
Or epigenomics that is
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Cast 18-Sep-22 03:03 PM
Ye
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macross89 18-Sep-22 03:04 PM
see it all seems to be a fear issue
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Cast 18-Sep-22 03:04 PM
Maoa-L gene
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macross89 18-Sep-22 03:04 PM
I'd be happy to try D-Serine
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Cast 18-Sep-22 03:04 PM
D serine seems like the best canidate
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Cast
Its a purposeful trait emerging from evolution
JK 18-Sep-22 03:04 PM
Whats the purpose?
15:04
Besides survival (edited)
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JK
Whats the purpose?
Cast 18-Sep-22 03:04 PM
Well its called the warrior gene
15:04
So u can infer from that
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JK 18-Sep-22 03:04 PM
huh
15:04
Yeah
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Cast 18-Sep-22 03:05 PM
Based on evolutionary psychology
15:05
Tribes needed men who could kill and raid
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JK 18-Sep-22 03:05 PM
Makes sense
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Cast 18-Sep-22 03:05 PM
And softies couldnt tolerate it without ptsd
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macross89 18-Sep-22 03:05 PM
maybe they all were taking d-serine
15:05
🥸
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JK 18-Sep-22 03:05 PM
They were
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macross89 18-Sep-22 03:05 PM
yeah
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JK 18-Sep-22 03:05 PM
Shamans orders
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Cast 18-Sep-22 03:05 PM
They were all pillaging and raping women
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macross89 18-Sep-22 03:06 PM
emoji_51
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JK 18-Sep-22 03:06 PM
Proud Viking genes over here
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Cast 18-Sep-22 03:06 PM
But im pretty sure
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macross89 18-Sep-22 03:06 PM
but thats not how the world works anymore
15:06
except maybe in africa
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Cast 18-Sep-22 03:06 PM
Not everyone who has maoa-l is ap psychopath
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macross89
but thats not how the world works anymore
JK 18-Sep-22 03:06 PM
Exactly
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macross89 18-Sep-22 03:06 PM
and middle east
15:06
haha
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Cast 18-Sep-22 03:06 PM
Theres other genes and epigentic factors
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macross89 18-Sep-22 03:06 PM
and probably ukraine
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JK 18-Sep-22 03:06 PM
Middle easterners all angry because it’s so fucking hot all the time
15:07
Constantly getting sand in your eyes etc
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macross89 18-Sep-22 03:07 PM
damn
15:07
they need sand goggles
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Cast 18-Sep-22 03:07 PM
Lol
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JK 18-Sep-22 03:07 PM
Would hate it as well
15:07
Yup
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Cast 18-Sep-22 03:07 PM
All those fuckers have maoa l
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macross89 18-Sep-22 03:07 PM
basically be the sand tribe in star wars
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JK 18-Sep-22 03:07 PM
No shit
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Cast 18-Sep-22 03:07 PM
LEL has maoa L
15:07
Hes middle eastern
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JK 18-Sep-22 03:07 PM
*talibangene
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macross89 18-Sep-22 03:07 PM
I'm getting a star warws rebel insignia tattoo
15:08
"regrats"
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JK 18-Sep-22 03:08 PM
You basically just need to join some rebel rogue formation (edited)
15:08
And adapt Jukesta
15:08
No noots needed
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macross89 18-Sep-22 03:08 PM
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Cast 18-Sep-22 03:08 PM
Hes what i think
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macross89
Click to see attachment 🖼️
JK 18-Sep-22 03:09 PM
“Punch my neck”
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Cast 18-Sep-22 03:09 PM
Take lsd. Get bullied and beat. Kill animals work ur way up insects -> frogs -> chipmunks -> pigs. Take d serine. Have lots of sex on tinder
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macross89 18-Sep-22 03:10 PM
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JK 18-Sep-22 03:10 PM
U should make an e-book
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Cast 18-Sep-22 03:10 PM
Its degenerate as fuck but u have to do it
15:10
U have to abandon empathy and fear
15:11
Also do stims
15:11
And molly
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macross89 18-Sep-22 03:11 PM
just damage your amydala bro
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Cast 18-Sep-22 03:11 PM
How tho?
15:11
U need a drug that damages amygdala without other areas
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macross89 18-Sep-22 03:11 PM
go back in time and edit your genes
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JK 18-Sep-22 03:11 PM
Jesus dose mushrooms
15:12
Get ptsd
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Cast 18-Sep-22 03:12 PM
No
15:12
Thatll make u beta
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macross89 18-Sep-22 03:12 PM
I have ptsd and all I have is ruminations
15:12
975870265147940914
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Cast 18-Sep-22 03:12 PM
Exactly
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JK 18-Sep-22 03:12 PM
You will get better bro
15:12
With time
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macross89 18-Sep-22 03:12 PM
I did before
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Cast 18-Sep-22 03:12 PM
It wont make u a psychopath
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macross89 18-Sep-22 03:12 PM
just gotta put effort
15:12
self love
15:13
not killing animals
15:13
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JK 18-Sep-22 03:13 PM
Have you tried p-serine for ptsd?
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Cast 18-Sep-22 03:13 PM
Self love will make u more empathetic
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JK 18-Sep-22 03:13 PM
Nukes cortisol
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macross89 18-Sep-22 03:13 PM
phosphatidylserine was one of the few supplements that I noticed anything lol
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Cast 18-Sep-22 03:13 PM
U have to work ur way up so u can stomach killing things
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macross89 18-Sep-22 03:13 PM
maybe it was the combo of phosphati and magnesium l-threonate
15:13
that shit was sedating as fuck
15:13
i was so contempt lol
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JK 18-Sep-22 03:14 PM
I don’t like killing things
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Cast 18-Sep-22 03:14 PM
Desensitize yourself to death
15:14
Work as a
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macross89 18-Sep-22 03:14 PM
PS-100 by AOR
15:14
shits expensive though
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Cast 18-Sep-22 03:14 PM
One of those guys who cleans corpses
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macross89 18-Sep-22 03:14 PM
60$ for 120 caps
15:14
i took 2 a day
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JK 18-Sep-22 03:14 PM
I used bulk
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macross89 18-Sep-22 03:14 PM
so 60 days for 60$
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JK 18-Sep-22 03:14 PM
Quality sucks
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macross89 18-Sep-22 03:14 PM
probably ^
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JK 18-Sep-22 03:14 PM
But it works
15:15
Get rashes from all their stuff
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macross89 18-Sep-22 03:15 PM
bulk supplments ?
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JK 18-Sep-22 03:15 PM
He
15:15
Ye
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macross89 18-Sep-22 03:15 PM
haha
15:15
maybe I need that crazy sedation
15:15
then maybe im not thinking as wmuch
15:15
i was so contempt
15:16
haha
15:16
it was funny
15:16
i probably had droopy eyes on that shit
15:16
like cannabis without the paranoia and mind altering crap
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JK 18-Sep-22 03:16 PM
I can’t smoke cannabis
15:16
Get shit paranoia
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macross89 18-Sep-22 03:16 PM
what do you think all my problems come from
15:16
didnt i say earlier lol
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JK 18-Sep-22 03:17 PM
Oh
15:17
Weed lol?
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macross89
chronic cannabis usage induced psychosis 5 days a week at lunch time in high school, which had me have constant negative intrusive thoughts and self hate and paranoia hearing and thinking people were watching me and making fun of me 24/7 for the next 3 years of using.
macross89 18-Sep-22 03:17 PM
this
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JK 18-Sep-22 03:17 PM
Yeah that should be solvable with behavior correction
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macross89 18-Sep-22 03:17 PM
my ptsd is from that
15:17
yeah
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JK 18-Sep-22 03:17 PM
I’d you even have ptsd
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macross89 18-Sep-22 03:17 PM
thats why I seek therapy now
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JK 18-Sep-22 03:17 PM
Maybe mild
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macross89 18-Sep-22 03:18 PM
its all learned
15:18
and engraved
15:18
into my mind
15:18
D-Serine would help
15:18
maybe
15:18
hopefully
15:18
exposure therapy
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JK 18-Sep-22 03:18 PM
Imo you need positive people around you, that you can be yourself to the core with, and do shit you are got at and get recognize for it
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macross89 18-Sep-22 03:18 PM
yeah
15:19
unfortunately I don't
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JK 18-Sep-22 03:19 PM
Then nothing to do. Listen to Jukesta and start cleaning corpses!
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macross89 18-Sep-22 03:19 PM
I even tried to reach out and hang around my cousin last summer which I thought like... "oh yeah this is family he will help" but he just made fun of me and made things 100% worse I went through extreme hell for the next few months
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MEE6 BOT 18-Sep-22 03:19 PM
@macross89, you have advanced to lvl 7 respect++ emoji_51
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macross89 18-Sep-22 03:19 PM
hair shedding
15:19
no sleep
15:19
constant panick attacks
15:19
what a famil
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JK 18-Sep-22 03:19 PM
Man that sucks
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macross89 18-Sep-22 03:19 PM
family
15:20
975869370045722694
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JK 18-Sep-22 03:20 PM
You can do it on your own
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macross89 18-Sep-22 03:20 PM
fuck yes
15:20
like I did before
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JK 18-Sep-22 03:20 PM
You will fall again, but each time you rise you are more resilient and robust
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macross89
constant panick attacks
Cast 18-Sep-22 03:21 PM
Brutal
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JK 18-Sep-22 03:21 PM
I believe in you
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Cast 18-Sep-22 03:21 PM
Psychopathy would cure u instantly
15:21
Imagine
15:21
No fear
15:21
No care about what people think of you
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Cast
Brutal
macross89 18-Sep-22 03:21 PM
I literally coudlnt breathe most of the day and my throat felt like it had a lump but I was hyperventilating
15:21
stress is no fucking joke
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Cast 18-Sep-22 03:21 PM
Approach hot girls with unlimited confidence
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macross89 18-Sep-22 03:21 PM
never hang around people who dont support you
15:21
...
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JK 18-Sep-22 03:21 PM
If you nuke your fear of death u die
15:21
Lol
15:21
Stop this
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Cast 18-Sep-22 03:21 PM
No u dont
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macross89 18-Sep-22 03:22 PM
hahaha
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Cast 18-Sep-22 03:22 PM
U still cognitvely dont want to die
15:22
And u dont get depressed
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macross89 18-Sep-22 03:22 PM
Embedded image
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JK 18-Sep-22 03:22 PM
You cognitively don’t want to die because without a body ther is no cognition, hence why u need to listen your your biological survival mechanism
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Cast 18-Sep-22 03:23 PM
Biological pussy mechanism
15:23
Embrace psychopathy
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JK 18-Sep-22 03:23 PM
That keeps u alive
15:23
So you can become a psychopath over discord
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Cast 18-Sep-22 03:23 PM
Psychopaths still live long lives
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JK 18-Sep-22 03:23 PM
I doubt it
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Cast 18-Sep-22 03:23 PM
Hm
15:24
Is there any drug that directly targets amygdala
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macross89 18-Sep-22 03:24 PM
look at people with ADHD
15:24
fucking idiots
15:24
those dumbasses statistically live shorter lives
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Cast 18-Sep-22 03:24 PM
If it upregulates it. I hope I could use excitotoxicity to shut it down
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JK 18-Sep-22 03:24 PM
I have adhd
15:25
I think
15:25
But
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macross89 18-Sep-22 03:25 PM
due to their thrilll seeking dumbass behavior
15:25
yeah well ADHD like most mental illnesses suck
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JK 18-Sep-22 03:25 PM
So yea
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macross89 18-Sep-22 03:25 PM
I might have it as well
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JK 18-Sep-22 03:25 PM
Might not become 200
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Cast 18-Sep-22 03:25 PM
Live 80 years as a depressed faggot or 40 years having the hottest sex u can imagine. Making six figure income and giving zero fucks about society and peoples opinions?
15:25
I choose the latter
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Original message was deleted or could not be loaded.
macross89 18-Sep-22 03:25 PM
damn
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JK 18-Sep-22 03:26 PM
It’s all good, I will fix shit soon
15:26
Tomorrow
15:26
After the dishes
15:26
….
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macross89 18-Sep-22 03:26 PM
🤣
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Cast 18-Sep-22 03:26 PM
Im looking for pub med articles gents
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macross89 18-Sep-22 03:27 PM
I tried amphetamine did nothing
15:27
i'm thinking maybe ritalin or vyvanse would help with adhd
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JK 18-Sep-22 03:27 PM
We do Ritalin in my country mostly
15:27
I tried it a few weekends ago
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Cast 18-Sep-22 03:27 PM
Theres 44k references to the amygdala need to narrow it down to just drugs that target amygdala function (edited)
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JK 18-Sep-22 03:27 PM
I swear next 4 days I was on point
15:27
Delayed capsules
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macross89 18-Sep-22 03:28 PM
I'm interested in the "adhd makes you less innatentive and easily distracted" and "emotional dysregulation"
15:28
think something that modulates the dopamine receptors would be good for that
15:28
less attentive*
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JK 18-Sep-22 03:28 PM
Oh no doubt dopamine upregulation is exactly what you want
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macross89 18-Sep-22 03:29 PM
its just annoying because so many mental illnesses symptoms overlap, im sure you've heard of that saying many times
15:29
thats why its a trial and error with medication
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JK 18-Sep-22 03:29 PM
Sure, is it stress or a fatal disease
15:29
Find out next episode
15:29
..
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macross89 18-Sep-22 03:29 PM
975869370045722694
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JK
Whats the purpose?
Netizenne 18-Sep-22 03:32 PM
https://ncase.me/trust/
The Evolution of Trust
an interactive guide to the game theory of why & how we trust each other
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Cast
Take lsd. Get bullied and beat. Kill animals work ur way up insects -> frogs -> chipmunks -> pigs. Take d serine. Have lots of sex on tinder
Netizenne 18-Sep-22 03:35 PM
https://youtu.be/UVuS4U22DJo You to find a schizophrenic cult leader to put you through their rebirth initiation
mesmerdan
V for Vendetta - Evey Reborn scene
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Cast 18-Sep-22 03:35 PM
https://pubmed.ncbi.nlm.nih.gov/30529341/
3,4-methylenedioxymethamphetamine (MDMA) impairs the extinction and...
Clinical trials have demonstrated that 3,4-methylenedioxymethamphetamine (MDMA) paired with psychotherapy is more effective at reducing symptoms of post-traumatic stress disorder (PTSD) than psychotherapy or pharmacotherapy, alone or in combination. The processes through which MDMA acts to enhance p …
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Netizenne
https://youtu.be/UVuS4U22DJo You to find a schizophrenic cult leader to put you through their rebirth initiation
Netizenne 18-Sep-22 03:35 PM
This is a real thing really crazy people do
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Cast 18-Sep-22 03:35 PM
Anxiety treatments arent enough
15:36
Psychopaths literally dont experience most emotions
15:36
It seems like a really specific purposeful trait
15:36
They just so happen to experience anger
15:37
Out of all the emotions
15:37
Thats not random
15:37
They exist to kill
15:37
Now they dont need to but
15:37
It wont be easy to induce psychopathy
15:38
I dont think its as simple as amygdala damage
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Cast
Desensitize yourself to death
Netizenne 18-Sep-22 03:38 PM
It’s just your own death you should be desensitized to
15:38
Play mortal games like lying in the street seeing if the cars will pull over and stop for you
💀 1
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Cast
They exist to kill
macross89 18-Sep-22 03:39 PM
lol well unfortunately they don't bear well in the current and future society
15:39
except if they move to africa or something
15:39
hahaha
15:40
or join the army
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Netizenne
It’s just your own death you should be desensitized to
Netizenne 18-Sep-22 03:40 PM
Or just do what normal people going down this route do and go sky diving or something. Wonder if you get better at conquering fear more generally after experiences like that?
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Netizenne
https://ncase.me/trust/
JK 18-Sep-22 03:41 PM
That was great!
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MEE6 BOT 18-Sep-22 03:41 PM
@JK, you have advanced to lvl 6 respect++ emoji_51
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Cast 18-Sep-22 03:41 PM
https://sci-hub.se/https://doi.org/10.1111/j.1469-7610.2006.01596.x
15:41
Gonna educate myself
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macross89 18-Sep-22 03:41 PM
you need to move to africa and join the militants
15:41
if you survive youll come back with less fear
15:42
but eventually youll return back to before due to surroundings
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Cast 18-Sep-22 03:42 PM
Not psychopathy tho
15:42
Psychopathy is not just no fear
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macross89 18-Sep-22 03:42 PM
we dont live in caveman era anymore
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Cast 18-Sep-22 03:42 PM
Its way more complex
15:44
I knew a psychopath
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JK
That was great!
Netizenne 18-Sep-22 03:45 PM
The tournament thing where they’ve got ratios of different strategies in a population -the whole theory around that is called evolutionarily stable strategies (ESS). Basically overall cooperative strategies tends to prevail over evil cheating strategies, but there’s always a small amount in a population.
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Cast 18-Sep-22 03:46 PM
He was a pathological liar. I was in the school gym alone with him. I just got done benching 2 plates and he went to the bench to try it. He failed and couldny do one rep even tho i didnt see. Next day he lied said he did two and people asked him to prove it but he said he sprained his shoulder
15:46
Sociopath*
15:46
Since he was impulsive
15:46
Just little stuff like that
15:46
But sociopath is bad
15:47
Psychopath is way more cunning and less impulsive
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Netizenne
The tournament thing where they’ve got ratios of different strategies in a population -the whole theory around that is called evolutionarily stable strategies (ESS). Basically overall cooperative strategies tends to prevail over evil cheating strategies, but there’s always a small amount in a population.
Netizenne 18-Sep-22 03:48 PM
I think cheaters and fast life history strategists probably overlap as they’re both selfish (edited)
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MEE6 BOT 18-Sep-22 03:48 PM
@Netizenne, you have advanced to lvl 11 respect++ emoji_51
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Netizenne
The tournament thing where they’ve got ratios of different strategies in a population -the whole theory around that is called evolutionarily stable strategies (ESS). Basically overall cooperative strategies tends to prevail over evil cheating strategies, but there’s always a small amount in a population.
JK 18-Sep-22 03:51 PM
Interesting, I will have to look into this. But as a purely matter of personal perspective, and according to my belief’s, I’d choose the cooperative side. I also managed to get equal results from pure cheating/cooperation.
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Netizenne
I think cheaters and fast life history strategists probably overlap as they’re both selfish (edited)
JK 18-Sep-22 03:51 PM
I agree
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JK
I agree
Netizenne 18-Sep-22 03:53 PM
Idk if the fast life history and cheaters overlap is so certain though.
15:53
I’d like to see studies bridging the two theories but google doesn’t return anything (edited)
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JK 18-Sep-22 03:53 PM
No but there might be a correlation in terms of egoistic tendencies
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macross89 18-Sep-22 03:54 PM
lol the company I work for set up a website and now its down haha
15:54
shit
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JK 18-Sep-22 03:55 PM
I tend to think of it as evolution dividing the roles
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macross89 18-Sep-22 03:55 PM
I think right now is a good opportunity for people to work
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JK 18-Sep-22 03:55 PM
All according to necessity
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macross89 18-Sep-22 03:55 PM
like find jobs
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JK 18-Sep-22 03:55 PM
Leaders won’t prevail by being too rigid etc (edited)
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Cast
It wont be easy to induce psychopathy
Pax1l 18-Sep-22 03:56 PM
Ive been in the mindstate of constant euphoria with being almost impervious to stress and being exceptionally high functioning. Going from those highs to states of boredom or entitlement really is not the best way to live a happy life
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JK 18-Sep-22 03:57 PM
But you need a certain amount of social plasticity with regards to building a pyramid etc
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JK
I tend to think of it as evolution dividing the roles
Netizenne 18-Sep-22 03:57 PM
Related
The competitive exclusion principle says that two species can't coexist if they occupy exactly the same niche (competing for identical resources). Two species whose niches overlap may evolve by natural selection to have more distinct niches, resulting in resource partitioning.
https://en.wikipedia.org/wiki/Competitive_exclusion_principle (edited)
Competitive exclusion principle
In ecology, the competitive exclusion principle, sometimes referred to as Gause's law, is a proposition that two species which compete for the same limited resource cannot coexist at constant population values. When one species has even the slightest advantage over another, the one with the advantage will dominate in the long term. This leads ei...
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Netizenne 18-Sep-22 04:20 PM
Since the heritability of personality is less than one, some combination of chance and the environment does affect the kind of personality which you develop, but only within certain genetic limits. An unstable, dangerous childhood will tend to increase mental instability, and those who experience it will learn to see the world as a dangerous place – and this may have a lasting effect on their behaviour (this calibration of adult behaviour to childhood environment is the subject of Life History studies in biology – humans as well as animals).[7] For instance, when childhood is unpredictable and dangerous, children will tend to be calibrated to ‘live for the now,’ so displaying lower Conscientiousness, and they may be suspicious of other people, leading to lower Agreeableness. Another example is that girls who have grown up in sexually-unstable situations seem to adopt a short-termist sexual strategy, having children with a variety of men who are chosen for their dominance (hence probably good genes) rather than their ability to remain committed to a relationship and provide resources over the long term. In slang terms, girls from unstable homes may exhibit a preference for ‘cads’ rather than ‘Dads’.[8]
16:22
Everything is about reproduction ultimately, when you follow the line of reasoning of why biological things are the way they are far back enough (edited)
16:22
http://geniusfamine.blogspot.com/?m=0
The Genius Famine
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tinidolphin 18-Sep-22 06:55 PM
hai
🥚 1
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Pax1l
Ive been in the mindstate of constant euphoria with being almost impervious to stress and being exceptionally high functioning. Going from those highs to states of boredom or entitlement really is not the best way to live a happy life
ibtisam.midlet 18-Sep-22 06:57 PM
level up
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ibtisam.midlet 18-Sep-22 07:22 PM
Guys what doesn't kill you makes you stronger, remember that 👍
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erin
https://catgirl.online/2020/05/05/comt-mutations-and-stimulants.html
ibtisam.midlet 18-Sep-22 07:49 PM
limits the body's ability to break down and remove neurotransmitters (NTs) by 3-4 times emoji_52
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erin 18-Sep-22 07:50 PM
sounds, right yeah
19:51
when i looked into it, i think it was like 25% the expected clearance rate for COMT Met/Met
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ibtisam.midlet 18-Sep-22 07:51 PM
I think its untuned dope system
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erin
sounds, right yeah
ibtisam.midlet 18-Sep-22 07:52 PM
Try to modulate receptors then the increase in neurotransmitters will only benefits you
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erin 18-Sep-22 07:52 PM
i take LDN for modulation
19:52
works well
19:53
keeps amph tolerance at bay for the most part
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ibtisam.midlet 18-Sep-22 07:53 PM
nice
19:54
Does it increase productivity in any manner
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ibtisam.midlet
nice
CEO 18-Sep-22 07:54 PM
You take any muscle relaxants
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erin 18-Sep-22 07:54 PM
without amph? idk i started it after going on stims
19:54
its an effective antidepressant for me
19:55
that was the primary reason i went on it
19:55
dopamine receptor sensitization was a side benefit :P
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CEO
You take any muscle relaxants
ibtisam.midlet 18-Sep-22 07:57 PM
Yeah, magnesium , occasional benzo, M1/3/4 antagonists and sometimes cabergoline
19:58
@erin what was your symptoms
20:00
Bromanatane increase dope in clean way
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erin 18-Sep-22 08:00 PM
i have year-round dysthymia, seasonal affective disorder, add-i, primary insomnia, upper airway resistance syndrome, and generalized anxiety disorder
20:01
also suspect mild me/cfs or some immunological condition
20:01
getting covid delta was a very fucking bad time
20:01
i was sick for 8 months
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ibtisam.midlet 18-Sep-22 08:03 PM
Mmm mostly they are because one underlying condition
20:04
But anyway it hard to know it
20:05
I would just gamble unique substance
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erin 18-Sep-22 08:07 PM
yeah
20:07
i had a lot of recurrent and chronic strep throat as a kid
20:07
as i understand it, that can lead to immunological fuckery
20:07
like persistent auto-immune response in the brain, neuroinflammation, etc.
20:08
leading to me/cfs and all sorts of wonderful things
20:08
but that was after the adhd diagnoses
20:09
pretty sure that one is genetic. perhaps also the depression
20:09
mom seems hella adhd, dad had a history of depression
20:10
im on some other mad science server with a dude who claims to have a model for these sorts of symptom clusters
20:11
but i dont have the spoons to follow his bonkers diet
20:11
he recommended liposomal thiamine but i havent tried it yet
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erin
like persistent auto-immune response in the brain, neuroinflammation, etc.
ibtisam.midlet 18-Sep-22 08:12 PM
Short term <7 days cortisone will bring if it is or not
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erin 18-Sep-22 08:16 PM
i doubt that reducing that response in the short term would produce a meaningful change. the chronic neuroinflammation and such causes lasting effects that dont undo overnight
20:22
but yeah i was gonna see a rheumatologist before i got covid and had to quit my job
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ibtisam.midlet 18-Sep-22 08:22 PM
If the Neuroinflammation was strong, it would {killed} you, underlying that it don't mess your system faster then it solve it self.
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erin 18-Sep-22 08:23 PM
im better now, just .. dont really give much of a fuck to go back to work 🙃 love to burn up all my savings
emoji_1 1
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ibtisam.midlet 18-Sep-22 08:23 PM
I'll to overspends
20:24
But work in the same time
20:24
Life is soo amazing when you know that you can spend any money you get
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erin 18-Sep-22 08:25 PM
yeah who needs to "retire"
20:25
ill just kill myself when i can no longer work
20:25
thatll solve that problem
😂 1
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ibtisam.midlet 18-Sep-22 08:25 PM
And stop wanting to get a house etc (edited)
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erin 18-Sep-22 08:26 PM
really, im already retired, i just act like im working 😎
20:26
when i was working, i only put in 4 hours a day
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ibtisam.midlet 18-Sep-22 08:26 PM
I love dope 3 975869691522326638
20:27
I don't care much for the outcome of my behaviors
20:27
Just fix the problem when it come
20:27
Amazing life baby
20:27
Noooo worry haha
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erin 18-Sep-22 08:28 PM
why wait til im 60 to go fly and meet a cute girl from the internet when i can spend all my money to live my dreams now
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erin
why wait til im 60 to go fly and meet a cute girl from the internet when i can spend all my money to live my dreams now
brothermanbill 18-Sep-22 08:30 PM
Buy pinealon a gram for $100 best money you can spend for a nasal substance powder lyophilized
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brothermanbill
Buy pinealon a gram for $100 best money you can spend for a nasal substance powder lyophilized
ibtisam.midlet 18-Sep-22 08:32 PM
That's not a cute girl
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erin 18-Sep-22 08:33 PM
look she might have a penis but that doesnt make her any less a girl
💟 1
20:33
:))
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ibtisam.midlet 18-Sep-22 08:34 PM
love them emoji_52
20:34
They can provide all type of sex
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erin
im on some other mad science server with a dude who claims to have a model for these sorts of symptom clusters
Pax1l 18-Sep-22 08:40 PM
Forming a model of cfs isnt fairly complicated, treating the pathology is a much larger question
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ibtisam.midlet
level up
Pax1l 18-Sep-22 08:41 PM
Oh I have certainly been there before. I had become quite adversarial but I was exceptionally motivated
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ibtisam.midlet
They can provide all type of sex
Pax1l 18-Sep-22 08:43 PM
Seems fairly antithetical to be so casual about sex when the goal of the server is developing a better understanding of nootropics.
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Pax1l
Seems fairly antithetical to be so casual about sex when the goal of the server is developing a better understanding of nootropics.
ibtisam.midlet 18-Sep-22 08:48 PM
You are in casual channel emoji_1
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Pax1l 18-Sep-22 09:09 PM
its a bit nsfw and should be in a +18 channel.
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erin 18-Sep-22 09:29 PM
lol
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MEE6 BOT 18-Sep-22 09:29 PM
@erin, you have advanced to lvl 4 respect++ emoji_51
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erin 18-Sep-22 09:30 PM
yeah we better not mention sexual biological function and anatomy someone might get fired from their job for reading about girlcock
21:30
🤣
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Pax1l 18-Sep-22 09:31 PM
no it should just be in its own chat for the sake of discord tos
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erin 18-Sep-22 09:31 PM
it isnt against discord tos to mention the existence of penis in a channel not marked nsfw
21:31
sorry, try again
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erin
https://catgirl.online/2020/05/05/comt-mutations-and-stimulants.html
Netizenne 18-Sep-22 09:32 PM
I saw you had an article on anti androgens!!!!! What are your thoughts on estrogen monotherapy? People say it’s dangerous to raise estrogen high enough to the point where it can suppress testosterone on its own but I don’t think it even actually goes above the estrogen levels of cis women on birth control. People say it increases heart risk, but that’s just part of being a women as well (higher heart risk). I haven’t looked at the exact numbers tho (The pharmaceutical industry has a history of sacrificing their customers health for profit so I am suspicious that they make trans people take estrogen+AAs just to sell more medicine but idk) (edited)
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erin
it isnt against discord tos to mention the existence of penis in a channel not marked nsfw
Netizenne 18-Sep-22 09:33 PM
It’s also against discord tos to be antivax 💀
21:33
rip
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erin 18-Sep-22 09:34 PM
its my understanding that the E2 levels required to fully suppress T without AAs is within cisfem range, albeit at the top end
21:34
well, the trough of the E2 cycle is within cisfem range
21:35
of course trans girls taking exogenous E2 spike well above cisfem range
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Damianze 18-Sep-22 09:35 PM
Do we usually use nanoparticles with diameter smaller than 10nm to deliver stuffs across the blood-brain barrier?
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MEE6 BOT 18-Sep-22 09:35 PM
@Damianze, you have advanced to lvl 2 respect++ emoji_51
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Damianze 18-Sep-22 09:35 PM
The nanoparticles were originally created to across the blood brain barrier, but most of the vessels inside the brain are non-fenestrated blood capillaries, which their windows/pores are less than 20nm. So any nanoparticles with diameter bigger than 20nm won't be able to pass those capillaries, and will stay inside the inner lining even if they entered the brain with circulation?
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erin
i love blogs! love reading a 10k word deep dive on some shit
Netizenne 18-Sep-22 09:36 PM
Recommend any good pharmacology, evolution, or bio ones..?
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erin 18-Sep-22 09:36 PM
but to answer your question, i dont think theres any inordinate danger in monotherapy, no
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Netizenne 18-Sep-22 09:37 PM
It’s a conspiracy They give trans people anti androgens to lobotomize them Wuhhhh
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erin 18-Sep-22 09:37 PM
its possible to go too high and cause a prolactinoma
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Netizenne 18-Sep-22 09:37 PM
I like my brains androgen receptors
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erin 18-Sep-22 09:37 PM
but you have to be poppin' trough measurements of like >1k pg/mL for that, sustained over long periods
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Netizenne
I like my brains androgen receptors
Netizenne 18-Sep-22 09:37 PM
Even normal women don’t get those blocked. Even cis women have a use for them (edited)
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Damianze
Do we usually use nanoparticles with diameter smaller than 10nm to deliver stuffs across the blood-brain barrier?
Pax1l 18-Sep-22 09:38 PM
There are functionalized particles such as liposomes, microemulsions, self assembling peptides that can also be used to promote the transport of compounds past the nasal epithelial barrier. It's a fairly common delivery vehicle for improving the therapeutic index and the passage of drugs into the brain
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erin 18-Sep-22 09:38 PM
it typically takes 250-550 pg/mL at trough to fully suppress T
21:38
and most people can manage it with 350pg/mL, which is the top end of cisfem range
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Netizenne
Even normal women don’t get those blocked. Even cis women have a use for them (edited)
erin 18-Sep-22 09:43 PM
its unclear if theres much use for them in women aside from libido. estrogen does mood regulation, sustains bone density, and libido the same as testosterone though. with a trans girl doing estrogen monotherapy, she'll be seeing an AuC that is higher than that of a cisfem person. this may result in making up for the libido losses to not having a meaningful amount of T. however uhhh, this is trans people we're talking about and a lot of them just.. dont mind that they dont have a libido because they dont want to even think about the fact they have a penis whatsoever
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Pax1l
Seems fairly antithetical to be so casual about sex when the goal of the server is developing a better understanding of nootropics.
Netizenne 18-Sep-22 09:43 PM
Everything is about reproduction ultimately, when you follow the line of reasoning of why biological things are the way they are far back enough. It’s central to evolution and the primary function the whole brains shaped to perform. Reproduction is all everything Prayge (edited)
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Pax1l
There are functionalized particles such as liposomes, microemulsions, self assembling peptides that can also be used to promote the transport of compounds past the nasal epithelial barrier. It's a fairly common delivery vehicle for improving the therapeutic index and the passage of drugs into the brain
Pax1l 18-Sep-22 09:45 PM
This is actually a very valuable search term among a few incredibly dedicated nootropics scholars. Being able to formulate such microemulsions, or gelatin nanoparticles, or even improving peptide delivery through liposomes or functionalized peptide conjugates. Someone I've worked closely with in the past developed a peptide conjugate called HA-P6 that had featured a Peptide bound to hylauronic acid. Hylauronic acid receptors are ubiquitous and help support the basement membranes of our cells so they readily transport into the brain. often peptide conjugates are more resistant to enzymatic degradation and I'm looking at exploring making a peptide conjugate with a self assembling peptide to promote greater neurogenesis and dendritic outgrowth.
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Pax1l
There are functionalized particles such as liposomes, microemulsions, self assembling peptides that can also be used to promote the transport of compounds past the nasal epithelial barrier. It's a fairly common delivery vehicle for improving the therapeutic index and the passage of drugs into the brain
Damianze 18-Sep-22 09:45 PM
So those are like nasal sprays, instead of injections?
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erin
its unclear if theres much use for them in women aside from libido. estrogen does mood regulation, sustains bone density, and libido the same as testosterone though. with a trans girl doing estrogen monotherapy, she'll be seeing an AuC that is higher than that of a cisfem person. this may result in making up for the libido losses to not having a meaningful amount of T. however uhhh, this is trans people we're talking about and a lot of them just.. dont mind that they dont have a libido because they dont want to even think about the fact they have a penis whatsoever
Netizenne 18-Sep-22 09:46 PM
I mean androgen receptors still have an increadibly vital role in female brains, they don’t just solely produce an externally feminine phenotype but also are involved in cognitive processes, development, and resource allocation. When a trans person takes anti androgens -how much are their brains androgen receptors functioning compared to a cis women? Estrogen monotherapy is kinda natural since the body is somewhat designed to be in estrogen -but not anti androgens. It’s unnatural I say, even for women!!!!!!!!!!!!! (edited)
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erin 18-Sep-22 09:47 PM
yeah, i dunno neti. like, i agree with you, its unnatural. i prefer monotherapy for this reason. the reality is though that some trans women literally cannot tolerate any T whatsoever because it makes them profoundly dysphoric and suicidal
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Damianze
So those are like nasal sprays, instead of injections?
Pax1l 18-Sep-22 09:47 PM
Yes the most novel delivery vehicle for drugs currently in research is through intranasal use to directly target the brain. Some of what I'm most enthusiastic is the creation of functionalized chitosan microparticles or microemulsions to improve passage to the brain
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Pax1l
Yes the most novel delivery vehicle for drugs currently in research is through intranasal use to directly target the brain. Some of what I'm most enthusiastic is the creation of functionalized chitosan microparticles or microemulsions to improve passage to the brain
Damianze 18-Sep-22 09:48 PM
Are there a lot of fenestrated capillaries in the brain as well?
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Pax1l 18-Sep-22 09:48 PM
I believe that Laminin derived peptide conjugates or functionalized microparticles can incorporate drugs or small molecules and transport them to the brain as well.
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Damianze 18-Sep-22 09:49 PM
https://link.springer.com/article/10.1007/s004410050678
Capillaries in the lamina propria of human seminiferous tubules are...
Cell and Tissue Research - The three capillary parts of the microvasculature of the human testis, namely the arterial side inter-Leydig cell capillaries, the intramural capillaries, and the venous...
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21:49
I just read this paper on Sci-Hub
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erin
yeah, i dunno neti. like, i agree with you, its unnatural. i prefer monotherapy for this reason. the reality is though that some trans women literally cannot tolerate any T whatsoever because it makes them profoundly dysphoric and suicidal
Netizenne 18-Sep-22 09:49 PM
Ya well estrogen suppresses it tho. It kills the balls. They can probably even go back to a lower dose possibly even once they’re balls are sufficiently killed and put out of production (SHOULD VERIFY THIS tho). I think the only reason people should take antiandrogens are if they’re old or have heart problems. I think I’ve heard that’s the way it was in certain European countries, us might just be f’ed. (edited)
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Damianze 18-Sep-22 09:49 PM
And I thought there are no fenestrated capillaries inside the testis
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Damianze
Are there a lot of fenestrated capillaries in the brain as well?
Pax1l 18-Sep-22 09:50 PM
Our nasal cillia and olfactory bulb is rich in mucous membranes that can transport molecules into the brain
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Damianze 18-Sep-22 09:50 PM
I read that the fenestrations on those capillaries are 60~80nm in diameter
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Pax1l 18-Sep-22 09:51 PM
It's actually a concern faced with air pollution that allows microscopic metal particles to penetrate into the brain and accumulate.
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Damianze 18-Sep-22 09:51 PM
So nanoparticles with diameter smaller than that will have very high permeating rate in the tissue?
21:51
Like in the testis the paper mentions
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Damianze
So nanoparticles with diameter smaller than that will have very high permeating rate in the tissue?
Pax1l 18-Sep-22 09:52 PM
yes. It's not too difficult to transport drugs into the brain intranasally. I do it several times a day
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Netizenne
Ya well estrogen suppresses it tho. It kills the balls. They can probably even go back to a lower dose possibly even once they’re balls are sufficiently killed and put out of production (SHOULD VERIFY THIS tho). I think the only reason people should take antiandrogens are if they’re old or have heart problems. I think I’ve heard that’s the way it was in certain European countries, us might just be f’ed. (edited)
erin 18-Sep-22 09:52 PM
spironolactone usually doesnt fully suppress T anyway fun fact though! i've been on transfem HRT for over 2 years. i decided to go off it for a month, and my gonads resumed normal functioning. they acutally came back EVEN MORE POWERFUL and when i went back on E2 injections, i found out a couple months later through labwork that the same dose i was using before was no longer enough to suppress T :))
despair 1
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Pax1l
yes. It's not too difficult to transport drugs into the brain intranasally. I do it several times a day
Damianze 18-Sep-22 09:53 PM
https://link.springer.com/article/10.1007/s004410050678 This paper says there are such capillaries as "semi-fenestrated"
Capillaries in the lamina propria of human seminiferous tubules are...
Cell and Tissue Research - The three capillary parts of the microvasculature of the human testis, namely the arterial side inter-Leydig cell capillaries, the intramural capillaries, and the venous...
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erin
spironolactone usually doesnt fully suppress T anyway fun fact though! i've been on transfem HRT for over 2 years. i decided to go off it for a month, and my gonads resumed normal functioning. they acutally came back EVEN MORE POWERFUL and when i went back on E2 injections, i found out a couple months later through labwork that the same dose i was using before was no longer enough to suppress T :))
Netizenne 18-Sep-22 09:53 PM
I had to go off estrogen cause my parents found my syringes and made me stop You have any ideas on what supplements, noots, or whatever you’d take in the meanwhile until I’m living on my own?
21:53
To suppress
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Damianze
https://link.springer.com/article/10.1007/s004410050678 This paper says there are such capillaries as "semi-fenestrated"
Damianze 18-Sep-22 09:53 PM
I just looked it up on Sci-hub, the article also says that most of those fenestrations are closed by diaphragms, so the particle permeation of those capillaries are not high even though they are fenestrated? Am I reading it correctly?
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erin 18-Sep-22 09:54 PM
lmao i just realised you have a catgirl PFP and are on ACXD, neti
21:54
based based based
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erin
lmao i just realised you have a catgirl PFP and are on ACXD, neti
Netizenne 18-Sep-22 09:55 PM
And qwerkyscience more notably!!!!!!!!!!
21:55
Best blog (sorry lol) (edited)
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Damianze
I just looked it up on Sci-hub, the article also says that most of those fenestrations are closed by diaphragms, so the particle permeation of those capillaries are not high even though they are fenestrated? Am I reading it correctly?
Pax1l 18-Sep-22 09:55 PM
Why are you learning about the capillary physiology of the gonads to study the blood brain barrier.
xd 1
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Netizenne
I had to go off estrogen cause my parents found my syringes and made me stop You have any ideas on what supplements, noots, or whatever you’d take in the meanwhile until I’m living on my own?
erin 18-Sep-22 09:55 PM
idk have you tried the 4chan femboy feminization guide
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Damianze 18-Sep-22 09:56 PM
The blood-brain-barrier and blood-testis barrier are very similar
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Pax1l 18-Sep-22 09:56 PM
The nasal epithelial barrier is within itself different physiologically than the blood brain barrier.
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Damianze 18-Sep-22 09:57 PM
Image attachment
21:58
Is this saying those fenestrations are closed by diaphragms so not much permeating?
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Pax1l 18-Sep-22 09:59 PM
I haven't read the same literature you're going from. I can't help you with that question unfortunately
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Pax1l
I haven't read the same literature you're going from. I can't help you with that question unfortunately
Damianze 18-Sep-22 09:59 PM
You can read it sci-hub
22:00
https://sci-hub.se/
Sci-Hub: everyone is a pirate — even scientists
Sci-Hub website. Get free access to academic journals. Download research papers for free from ScienceDirect, IEEE, Wiley, Springer, Nature and others
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Pax1l 18-Sep-22 10:01 PM
what Im most familiar with regarding the delivery of drugs to the brain is creating delivery vehicles for the delivery of compounds past the nasal epithelial barrier.
22:02
If its your goal I can share some literature based on that later
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erin
idk have you tried the 4chan femboy feminization guide
Netizenne 18-Sep-22 10:03 PM
You ever heard of liquiritigenin? It’s an estrogen receptor b agonist I’m gonna buy. Not sure of the full range of effects to expect from it. Seems it causes a feminine weight distribution (more pear than apple shaped) but at the same time it also darkens skin (which estrogen does the opposite of) and increases muscle (although maybe it’s just thigh it’s increasing considering the pear thing hopefully but idk). So in some ways it almost seems like it could have opposite effects of estrogen receptor a agonists (and estrogen in general). Another way it’s the opposite of estrogen receptor a agonists is that it decreases breast size. (edited)
22:03
Spooky and don’t know what to expect
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Pax1l
what Im most familiar with regarding the delivery of drugs to the brain is creating delivery vehicles for the delivery of compounds past the nasal epithelial barrier.
Damianze 18-Sep-22 10:04 PM
You have experience of drug delivery using nanoparticles?
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Pax1l 18-Sep-22 10:04 PM
I have a couple hundred grams in my desk. I don't believe that its effects are that direct on peripheral estrogen signaling.
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Damianze
You have experience of drug delivery using nanoparticles?
Pax1l 18-Sep-22 10:05 PM
Yes I've read literature based on the creation of different drug delivery vehicles. I believe its some of the most revolutionary concepts in modern medicine.
22:06
I've looked at RGD peptide, Lactoferrin, and dha delivery vehicles for transport of compounds past the nasal epithelial barrier.
22:07
Even gold nanoparticles can be functionalized to incorporate peptides or amino acids which can deliver compounds past the blood brain barrier.
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Pax1l
Even gold nanoparticles can be functionalized to incorporate peptides or amino acids which can deliver compounds past the blood brain barrier.
Damianze 18-Sep-22 10:08 PM
What about using nanoparticles for gene delivery?
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Damianze
What about using nanoparticles for gene delivery?
Pax1l 18-Sep-22 10:09 PM
There is literature I've seen of functionalizing peptides and viruses to deliver dna plasmids to the brain.
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erin
spironolactone usually doesnt fully suppress T anyway fun fact though! i've been on transfem HRT for over 2 years. i decided to go off it for a month, and my gonads resumed normal functioning. they acutally came back EVEN MORE POWERFUL and when i went back on E2 injections, i found out a couple months later through labwork that the same dose i was using before was no longer enough to suppress T :))
Netizenne 19-Sep-22 12:03 AM
Image attachment
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Cast 19-Sep-22 01:34 AM
Can dmso be swallowed
01:34
Im trying to think of more potent delivery mechanisms for prl 8 53
01:35
IN will probably cause nasal irritation Sublingual may cause enamel decay Oral isnt as potent as the previous roas. So im thinking of an alternativr that could be massively more potent
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ibtisam.midlet 19-Sep-22 02:20 AM
IM x4 more potent
02:23
@Cast
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ibtisam.midlet
IM x4 more potent
Cast 19-Sep-22 02:29 AM
Intramuscular?
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Cast
Intramuscular?
ibtisam.midlet 19-Sep-22 02:30 AM
yea
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ibtisam.midlet 19-Sep-22 02:38 AM
cause a strong desire, if not impulse, to wander, travel and explore the world. https://www.entrepreneur.com/living/there-is-a-wanderlust-gene-but-you-can-be-a-digital-nomad/311322
There Is a 'Wanderlust Gene' but You Can be a Digital Nomad Even Wi...
Science now has a partial explanation why some people love to travel.
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02:39
DRD4-7R
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ibtisam.midlet
cause a strong desire, if not impulse, to wander, travel and explore the world. https://www.entrepreneur.com/living/there-is-a-wanderlust-gene-but-you-can-be-a-digital-nomad/311322
Cast 19-Sep-22 02:40 AM
Travel is gay when america is the best
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ibtisam.midlet 19-Sep-22 02:42 AM
Wanderlust Gene hehe
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ibtisam.midlet 19-Sep-22 02:58 AM
in fact dopamine 4 agonists was constantly used to increase libido, after they found female have discovery behaviors to new sex position
03:02
one time trial the girl jump over company CEO, the substance get discontinued
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Avatar
Netizenne
You ever heard of liquiritigenin? It’s an estrogen receptor b agonist I’m gonna buy. Not sure of the full range of effects to expect from it. Seems it causes a feminine weight distribution (more pear than apple shaped) but at the same time it also darkens skin (which estrogen does the opposite of) and increases muscle (although maybe it’s just thigh it’s increasing considering the pear thing hopefully but idk). So in some ways it almost seems like it could have opposite effects of estrogen receptor a agonists (and estrogen in general). Another way it’s the opposite of estrogen receptor a agonists is that it decreases breast size. (edited)
Mabus Tiefsee 19-Sep-22 03:45 AM
from the effects, it sound like itvalso binds to some testosterone receotors?
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ibtisam.midlet
in fact dopamine 4 agonists was constantly used to increase libido, after they found female have discovery behaviors to new sex position
JK 19-Sep-22 04:52 AM
I will be bringing dopamine 4 agonists, to the next party I’m attending..
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Netizenne
I had to go off estrogen cause my parents found my syringes and made me stop You have any ideas on what supplements, noots, or whatever you’d take in the meanwhile until I’m living on my own?
veganpermanently 19-Sep-22 05:12 AM
975869370045722694
05:13
parents are enemies of experimentation
05:14
as is Andrew Huberman
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erin 19-Sep-22 05:18 AM
no parents allowed
05:18
ban them
💯 1
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macross89 19-Sep-22 05:25 AM
Wtf
05:26
I searched how much firefighters make in my country
05:26
On reddit
05:26
Multiple users with experience say 100k
05:26
One user said 100k after his first year
05:26
Another said after 3 1/2 years
05:27
It's crazy to me how brainless jobs that require like 0 intellect education can make so much
05:27
Maybe I shouldnt waste away 4 years of my life on a bachelor's in automation and robotics (edited)
05:27
975870265147940914
05:28
You could be a security guard or any job for a bank or that protects big money and literally do fuckall and make more than people who are actually making advancements to the world
05:29
975870265147940914 975870265147940914 975870265147940914 975870265147940914
05:30
Like real estate agents who have 0 brains and just right a quick paper to sell a home owners homes and makes biggggg monei (edited)
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macross89
Maybe I shouldnt waste away 4 years of my life on a bachelor's in automation and robotics (edited)
veganpermanently 19-Sep-22 05:31 AM
imagine if u were an artist
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macross89 19-Sep-22 05:32 AM
It makes no sense the little compensation people make for their skills
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erin 19-Sep-22 05:32 AM
if i were the ruler of the universe you would all make at least $50k/yr
05:32
even if u are doing menial labour in the coffee bean mines of starbucks
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veganpermanently
imagine if u were an artist
brothermanbill 19-Sep-22 05:33 AM
Imagine if he didn’t use the “975870265147940914 “
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macross89 19-Sep-22 05:33 AM
Who gives a shit about firefighters and police, there's literally like 7500 applications at a time, so it's oversaturated but still they get paid so much
05:33
975869370045722694
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macross89
Maybe I shouldnt waste away 4 years of my life on a bachelor's in automation and robotics (edited)
erin 19-Sep-22 05:33 AM
yes
05:33
or programming
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macross89 19-Sep-22 05:34 AM
Maybe I shouldn't*
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erin 19-Sep-22 05:34 AM
no
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macross89 19-Sep-22 05:34 AM
Edited
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erin 19-Sep-22 05:34 AM
become an indentured slave
05:34
youll pay off the loans soon enough
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brothermanbill
Imagine if he didn’t use the “975870265147940914 “
macross89 19-Sep-22 05:35 AM
975869370045722694
05:35
Seriously though
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erin 19-Sep-22 05:35 AM
and then in a decade of working you can take a couple years of a break and blow thru all ur savings like me
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macross89 19-Sep-22 05:36 AM
Uhm
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erin 19-Sep-22 05:37 AM
legit tho, i got up to ~130k/yr and made more money than i knew what to do with
05:37
its a good life if u can make it
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macross89 19-Sep-22 05:37 AM
What do you do
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erin 19-Sep-22 05:37 AM
software automation/devops
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erin
if i were the ruler of the universe you would all make at least $50k/yr
veganpermanently 19-Sep-22 05:37 AM
that's average in USA
05:37
why that number
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erin 19-Sep-22 05:38 AM
because 50k/yr is enough to live comfortably
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veganpermanently 19-Sep-22 05:38 AM
if I was the ruler money would be outlawed
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erin 19-Sep-22 05:38 AM
anywhere in the US
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veganpermanently 19-Sep-22 05:38 AM
cut hands for handling money
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erin 19-Sep-22 05:38 AM
well almost anywhere
05:38
lol
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veganpermanently
if I was the ruler money would be outlawed
brothermanbill 19-Sep-22 05:38 AM
We trade in gold nuggets, gems, swords, armour, trinkets odds and ends that sort of thing
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veganpermanently
if I was the ruler money would be outlawed
erin 19-Sep-22 05:39 AM
well sure but thatd require EFFORT
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macross89 19-Sep-22 05:39 AM
130k for deteriorating your body (not active job) and deteriorating your brain from overusing it on complicated task While a firefighter makes 100k after a year literally sitting around goofing with his colleagues and exercising out in the fresh air
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brothermanbill 19-Sep-22 05:39 AM
Cere with a lot maoi action is very interesting how the shadow figures come out to play hehehhe
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erin 19-Sep-22 05:39 AM
lol deteriorating your brain
05:39
what are u a baka dummy smoothbrain
05:39
dont think too hard youll hurt urself
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macross89 19-Sep-22 05:40 AM
What, you think that it's justified that a firefighter or police man makes close to your pay in a year doing... Driving around and spraying a water hose at fire (aka fun times)
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erin 19-Sep-22 05:41 AM
yes
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macross89 19-Sep-22 05:41 AM
You're underpaid for what you offer
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erin 19-Sep-22 05:41 AM
theyre paid for risking their life
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macross89 19-Sep-22 05:41 AM
Wayyy
05:41
If a firefighter makes that much compared to you
05:41
Lol risking their lives
05:41
emoji_2
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brothermanbill 19-Sep-22 05:42 AM
We must pay lots of tax money to our police and firefighter and ambulam and coast guard for out safety and security
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erin 19-Sep-22 05:42 AM
also firefighters do need knowledge of physics and shit to do complicated jobs
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MEE6 BOT 19-Sep-22 05:42 AM
@erin, you have advanced to lvl 5 respect++ emoji_51
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erin 19-Sep-22 05:42 AM
look all im saying is that if someone wanted me to wear a 50lb suit and run into a burning building or get into a helicopter and strategically drop fire retardenant on woodlands id wanna be paid a lot of money too
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brothermanbill
We must pay lots of tax money to our police and firefighter and ambulam and coast guard for out safety and security
veganpermanently 19-Sep-22 05:43 AM
no it's because of karens
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macross89 19-Sep-22 05:43 AM
I disagree but that's imo
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erin 19-Sep-22 05:44 AM
like i said i think everyone should be paid well no matter what u do
05:44
everyone deserves a comfortable life
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veganpermanently 19-Sep-22 05:44 AM
100% of tax money to military
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erin 19-Sep-22 05:44 AM
except for doctors
05:44
doctors should be paid less
05:44
fuck doctors
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macross89 19-Sep-22 05:45 AM
Why
05:45
Why doctors
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erin 19-Sep-22 05:45 AM
idk what ur experience with doctors are but ive been chronically ill and seeing a 4+ doctors a week for years now
05:45
and theyre fucking retarded and never solve my problems nor even know how to answer my questions
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veganpermanently 19-Sep-22 05:45 AM
the only issue with military is that it has the propensity to create tyrannical overthrow of self governance
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erin 19-Sep-22 05:45 AM
and at their worst theyre insulting and patronizing to boot
05:46
or actively harmful by suggesting retarded things and not reading my chart (edited)
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erin
or actively harmful by suggesting retarded things and not reading my chart (edited)
veganpermanently 19-Sep-22 05:46 AM
they wanted me on SSRI, diazepam and tramadol
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macross89 19-Sep-22 05:46 AM
Do you have any ideas what your illness could be a result of
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veganpermanently 19-Sep-22 05:47 AM
little did they know
05:47
I did my homework
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macross89 19-Sep-22 05:47 AM
So did i
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erin 19-Sep-22 05:47 AM
isnt ssri+tramadol an ss risk (edited)
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erin
isnt ssri+tramadol an ss risk (edited)
veganpermanently 19-Sep-22 05:47 AM
isn't diazepam a dementia and addiction risk
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erin 19-Sep-22 05:48 AM
lol
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veganpermanently 19-Sep-22 05:48 AM
isn't tramadol a crippling risk
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erin 19-Sep-22 05:48 AM
ur cute
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veganpermanently 19-Sep-22 05:48 AM
isn't SSRI a risk for severe and permacrippling of sexual function
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macross89 19-Sep-22 05:48 AM
The fear mongering lol
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macross89
The fear mongering lol
veganpermanently 19-Sep-22 05:49 AM
the stats say the otherwise
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erin 19-Sep-22 05:49 AM
i see
05:49
no, im talking about tangibly harmful things
05:49
like suggesting combos that actually would like put me in the hospital
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veganpermanently 19-Sep-22 05:49 AM
yeah limp dicks are not tangible
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macross89 19-Sep-22 05:49 AM
I don't believe in the perma thing, makes no sense imo
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veganpermanently 19-Sep-22 05:50 AM
well that's your problem
05:50
ain't it
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erin 19-Sep-22 05:50 AM
evito i cant tell if youre being serious and youre not exactly speaking clearly
05:51
but yeah i dont really take addiction risk seriously, and personally, ive never experienced marked sexual function impairment on serotonergics
05:51
but there are ways to mitigate all those risks
05:51
easily
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macross89 19-Sep-22 05:51 AM
Also I'd rather use something that actually works like pharma at 1/5 the price of dumbass placebo waste of money supplements where people spend like hundreds of dollars a month combining all these dumbass supplements cause they read it does something good, combing them all for like 1/100th the effect of a pharma medication that is like 10$
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erin 19-Sep-22 05:51 AM
so yeah im not really taking these things ur saying srsly
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macross89 19-Sep-22 05:51 AM
Based on experience of course
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veganpermanently 19-Sep-22 05:52 AM
I use pharmaceutical
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macross89 19-Sep-22 05:52 AM
Good
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veganpermanently 19-Sep-22 05:52 AM
but only the good ones
05:53
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macross89 19-Sep-22 05:53 AM
Yeah
05:53
emoji_21 emoji_18
05:53
emoji_21 emoji_21 emoji_21
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veganpermanently 19-Sep-22 05:53 AM
Modafinil the best antidepressant in the world
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erin 19-Sep-22 05:53 AM
whoa
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macross89 19-Sep-22 05:53 AM
Yeah it's good
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erin 19-Sep-22 05:53 AM
hot take
05:53
moda just gave me migraines
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erin
moda just gave me migraines
veganpermanently 19-Sep-22 05:53 AM
what moda
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erin 19-Sep-22 05:53 AM
actual moda
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veganpermanently 19-Sep-22 05:54 AM
armoda?
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erin 19-Sep-22 05:54 AM
no
05:54
modafinil
05:54
the OG
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macross89 19-Sep-22 05:54 AM
Mirtazapine is an antidepressant worth looking into if you don't want common SSRI side effects like sexual sides
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erin
the OG
veganpermanently 19-Sep-22 05:54 AM
armoda is the OG
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macross89 19-Sep-22 05:54 AM
I use it and done my research beforehand
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erin 19-Sep-22 05:54 AM
dude
05:54
just
05:54
modafinil
05:54
nothing else added
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veganpermanently 19-Sep-22 05:54 AM
the racemic mixture is weaker and more sides
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macross89 19-Sep-22 05:55 AM
Moda makes my pee yellow and smell very strong
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macross89
Mirtazapine is an antidepressant worth looking into if you don't want common SSRI side effects like sexual sides
erin 19-Sep-22 05:55 AM
i wrote like 10k words on mirtazapine/nefazodone and failed to understand how itd interact with my stack or not like, kill me so
05:55
didnt end up trying it
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veganpermanently 19-Sep-22 05:55 AM
the thing about VMAT2 upregulation
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erin 19-Sep-22 05:55 AM
still have a bottle each tho
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macross89 19-Sep-22 05:55 AM
It makes me want to die when I inevitably get a wiff of it
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veganpermanently 19-Sep-22 05:55 AM
it doesn't work unless you work
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macross89 19-Sep-22 05:56 AM
So it's more useful for dumbass firefighters gotcha
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veganpermanently 19-Sep-22 05:56 AM
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macross89 19-Sep-22 05:57 AM
Man the tour the France want to be cyclist are so fucking annoying
05:57
Like 70% of the time they're just pricks
05:57
Assholes on the road
05:58
They literally think they're joining the tour de france
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JK 19-Sep-22 05:59 AM
Or maybe.. Just MAYBE! It's really dangerous cycling +60kmh on the bicycle path..
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macross89 19-Sep-22 06:01 AM
Sleep goes a long fucking way
06:01
I've been insomniac for a decade
06:01
Nothing helped until I used mirtazapine
06:02
Now I'm out for two days and not getting sleep again
06:02
Man u must be writing a story
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JK 19-Sep-22 06:02 AM
How many mg are u taking?
06:03
i recall feeling like a zombie
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macross89 19-Sep-22 06:03 AM
35
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MEE6 BOT 19-Sep-22 06:03 AM
@macross89, you have advanced to lvl 8 respect++ emoji_51
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macross89 19-Sep-22 06:03 AM
Going up to 45 on next refill today
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JK 19-Sep-22 06:03 AM
yeah 35 made me feel like i was moving in water
06:03
but you do manage to sleep!
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veganpermanently 19-Sep-22 06:03 AM
Mitochondrial dysfunction is plaguing modern day society like never before because never before have we been so domesticated, so sedentary giving so little incentive to the mitochondria to produce cellular energy. All of the mental diseases implicate the same problem and will only get worse as long as we get worse. Release of monoamines and glutamate depends on cellular energy if there is none we will be castrated in terms of emotion, motivation, focus.
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JK 19-Sep-22 06:04 AM
4mg delayed melatonin fcking wakes me up in the middle of the night
06:04
ruins my sleep
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macross89 19-Sep-22 06:04 AM
It's all good, I just use skq1
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veganpermanently
Mitochondrial dysfunction is plaguing modern day society like never before because never before have we been so domesticated, so sedentary giving so little incentive to the mitochondria to produce cellular energy. All of the mental diseases implicate the same problem and will only get worse as long as we get worse. Release of monoamines and glutamate depends on cellular energy if there is none we will be castrated in terms of emotion, motivation, focus.
macross89 19-Sep-22 06:04 AM
@this
06:04
I never found melatonin tondo anything
06:04
People are saying lower doses are actually effective
06:04
Like 300mcg
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macross89
It's all good, I just use skq1
JK 19-Sep-22 06:04 AM
How long have u been using? And for what
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macross89 19-Sep-22 06:05 AM
For longevity/health promotion
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macross89
Like 300mcg
JK 19-Sep-22 06:05 AM
I know, but even 2 mg doesn't do anything for me, besides waking me up
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macross89 19-Sep-22 06:05 AM
I used two for sirsads vials but stupidly did it all in 5 days
06:05
Now I have to get more
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JK 19-Sep-22 06:05 AM
sounds expensive
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macross89 19-Sep-22 06:05 AM
It's difficult to dose cause it's so little you need
06:06
And there's so little to work with
06:06
His vials are fucking tiny
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veganpermanently
Mitochondrial dysfunction is plaguing modern day society like never before because never before have we been so domesticated, so sedentary giving so little incentive to the mitochondria to produce cellular energy. All of the mental diseases implicate the same problem and will only get worse as long as we get worse. Release of monoamines and glutamate depends on cellular energy if there is none we will be castrated in terms of emotion, motivation, focus.
JK 19-Sep-22 06:07 AM
Can't we just megadose a fat-soluble form of Thiamine? (edited)
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JK
Can't we just megadose a fat-soluble form of Thiamine? (edited)
veganpermanently 19-Sep-22 06:07 AM
nothing will work as good as endurance exercise
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macross89 19-Sep-22 06:07 AM
I searched multi vitamin and mineral supp all in one, they're really not expensive as opposed to what I would have thought
06:07
Gonna get on that shit
06:07
Real quick
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veganpermanently
nothing will work as good as endurance exercise
JK 19-Sep-22 06:08 AM
What do you do yourself? HIIT?
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JK
What do you do yourself? HIIT?
veganpermanently 19-Sep-22 06:08 AM
cycling
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macross89
I searched multi vitamin and mineral supp all in one, they're really not expensive as opposed to what I would have thought
JK 19-Sep-22 06:08 AM
I'm confused about bioavailability of multies
06:08
Nice
06:08
my dad does as well
06:09
tried it a few, not really for me
06:09
but it's damn good exercise
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macross89 19-Sep-22 06:09 AM
I literally can't expect to sit around all day and be healthy no matter how many supps I take, now I'm starting 30 Mon cardio a day and increase overtime
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JK 19-Sep-22 06:10 AM
start by walking 10k steps a day
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JK
I'm confused about bioavailability of multies
macross89 19-Sep-22 06:10 AM
Idk didn't really do much research but I suppose just get highly bioavailable one?
06:10
I use trusted brands that usually know what they're doing by including things like piperine and other things to the main ingredient to actually make them bioavailable
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macross89
Idk didn't really do much research but I suppose just get highly bioavailable one?
JK 19-Sep-22 06:11 AM
i don't think it matter much. most vitamins combat for absorbtion. Don't think there are any studies showing positive benefits in terms of cardiovascular og cognitivity etc
06:11
Just eat a variety of veggies, and move
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macross89 19-Sep-22 06:12 AM
Image attachment
06:12
Damn
06:12
Multi vitamins a fad?
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JK 19-Sep-22 06:13 AM
i mean current scientific consensus says somewhat
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macross89 19-Sep-22 06:13 AM
There's probably so many normies that take it 🤣
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JK 19-Sep-22 06:13 AM
woman might benefit during pregnancy (edited)
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macross89 19-Sep-22 06:13 AM
That's good to know
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JK 19-Sep-22 06:14 AM
but i can't find any studies with regards to healthy people getting significant benefits from a multi
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veganpermanently 19-Sep-22 06:14 AM
multivitamin large scale studies show no benefit for a few reasons
06:14
it's not like supplementing vitamins doesn't do anything
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macross89 19-Sep-22 06:14 AM
I need to look into it
06:14
I'm interested
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veganpermanently 19-Sep-22 06:15 AM
but putting all of them in a single pill cancels much of the benefits
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JK 19-Sep-22 06:15 AM
right, thats what i gathered as well
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macross89 19-Sep-22 06:15 AM
So how should they all be taken
06:15
At different times a day
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veganpermanently 19-Sep-22 06:15 AM
it's a dumb thing to do that disregards the principle of the most limiting factor
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macross89 19-Sep-22 06:15 AM
Like Im talking about a multi vitamin+ mineral, there's so many
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JK 19-Sep-22 06:16 AM
exactly my thought was all the limiting factors are often not taken into account even with single vitamin intake
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veganpermanently 19-Sep-22 06:16 AM
which states as follows: 1. Administering the most limiting factor will yield most benefit 2. Diluting the most limiting factor with other factors will dilute it's benefits
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macross89 19-Sep-22 06:16 AM
I guess just eat a variety diet
06:17
Maybe the only vitamins and minerals that are really proven to be life extending are like vitamin B12 and vitamin D3+k2 and iodine
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JK 19-Sep-22 06:17 AM
so get your bloodtests done, correct whats needed
06:17
disregard else
06:17
?
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JK
so get your bloodtests done, correct whats needed
veganpermanently 19-Sep-22 06:17 AM
that would cost more than supplying all vitamins
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macross89 19-Sep-22 06:17 AM
Yeah but you do it once
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veganpermanently 19-Sep-22 06:17 AM
IMO you just need to separate them in time
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macross89 19-Sep-22 06:17 AM
A year maybe
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veganpermanently 19-Sep-22 06:18 AM
according to competition and circadian rhythm effects
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JK 19-Sep-22 06:18 AM
i'm not going to ingest a whole pharmacy worth of vitamins and minerals lol
06:18
my liver/kidney will scream
06:18
times in my life i've felt the best i only took proteinpowder
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JK
i'm not going to ingest a whole pharmacy worth of vitamins and minerals lol
veganpermanently 19-Sep-22 06:18 AM
I'll run trials with high dose B vitamins
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JK 19-Sep-22 06:19 AM
okay yeah sure, i do as well
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JK
times in my life i've felt the best i only took proteinpowder
veganpermanently 19-Sep-22 06:19 AM
what else did you do
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JK 19-Sep-22 06:19 AM
allithiamine etc
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veganpermanently 19-Sep-22 06:19 AM
EXERCISE
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JK 19-Sep-22 06:19 AM
but yes
06:19
EXERCISE
06:19
above everything
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JK
okay yeah sure, i do as well
veganpermanently 19-Sep-22 06:19 AM
u don't do what I'll do
06:19
no one has done this
06:19
that's why I wanna do it
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JK 19-Sep-22 06:19 AM
explain then?
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veganpermanently 19-Sep-22 06:19 AM
I just did
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JK 19-Sep-22 06:19 AM
i've done pure enzymatic upregulation
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veganpermanently 19-Sep-22 06:19 AM
u didn't listen
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veganpermanently
I'll run trials with high dose B vitamins
JK 19-Sep-22 06:20 AM
what trials?
06:20
??
06:20
i'm trying but your description is vague
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veganpermanently 19-Sep-22 06:20 AM
no I was diluted by the least limiting factor
06:20
named macro something
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macross89 19-Sep-22 06:21 AM
I'm gonna start supplementing low molecular weight hyaluronic acid
06:21
Might help my chronic dry lips
06:21
Even though I drink plenty of water
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macross89
I'm gonna start supplementing low molecular weight hyaluronic acid
JK 19-Sep-22 06:21 AM
Thought about this as well
06:21
along with the mitovan
06:21
topical
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macross89 19-Sep-22 06:22 AM
Yeah honestly the skq1 as topical cosmetic is probably leads better than anything for skincare
06:22
If you applying on eyelids it probably affects the eyes as well
06:22
But I'm gonna also buy the eye drops
06:23
Crazy how obscure it is
06:23
I'm gonna gatekeep it from the normies 😈
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JK 19-Sep-22 06:23 AM
Haven't seen much feedback on it
06:23
perhaps thats why lol
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macross89 19-Sep-22 06:23 AM
Only I'm allowed to look young forever 🤣
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JK 19-Sep-22 06:23 AM
Hi Jukesta?
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macross89 19-Sep-22 06:24 AM
No
06:24
I've always been a selfish gatekeeper
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JK 19-Sep-22 06:25 AM
man i'm not
06:25
i want the best for everyone
06:25
we need to reach the finnish line as a team
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macross89 19-Sep-22 06:25 AM
Well not always
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JK 19-Sep-22 06:25 AM
can't build a pyramid on your own
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macross89 19-Sep-22 06:25 AM
Or at least not as bad
06:26
I think i really started gatekeeping once I started having terrible experiences with people
06:26
Aka hate for people in general
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JK 19-Sep-22 06:26 AM
other peoples behaviour wont change me for shit
06:26
i have my morals
06:26
my integrity
06:26
fuck what others do
06:26
or society for that matter
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JK
can't build a pyramid on your own
veganpermanently 19-Sep-22 06:26 AM
pyramid wasn't built for the people
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JK 19-Sep-22 06:26 AM
but it was built BY people
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macross89 19-Sep-22 06:27 AM
Yeah but I was in a state of psychosis and schizophrenia from the cannabis abuse so it's a different story if yours isn't similar
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JK
but it was built BY people
veganpermanently 19-Sep-22 06:27 AM
for a tyrannical leader they were brainwashed to think is god
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macross89
Yeah but I was in a state of psychosis and schizophrenia from the cannabis abuse so it's a different story if yours isn't similar
JK 19-Sep-22 06:27 AM
i've smoked half an oceans worth of weed my man
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veganpermanently
for a tyrannical leader they were brainwashed to think is god
JK 19-Sep-22 06:27 AM
and now we have a glorious tourist attraction, isn't that wonderfull
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JK
and now we have a glorious tourist attraction, isn't that wonderfull
veganpermanently 19-Sep-22 06:28 AM
nah that's just stupid
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JK 19-Sep-22 06:28 AM
well luckily you have the option, to not participate in building one
06:29
feel free to go cycling instead brother
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JK
feel free to go cycling instead brother
veganpermanently 19-Sep-22 06:29 AM
busy solving aging
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macross89 19-Sep-22 06:29 AM
Man not getting good sleep these past two nights is already taking a toll on my mental stability
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veganpermanently 19-Sep-22 06:30 AM
thinking about getting an indoor bike so I can solve aging and solve aging too if u get what I mean
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macross89
Man not getting good sleep these past two nights is already taking a toll on my mental stability
JK 19-Sep-22 06:30 AM
Almost considering Mirtazapine just to get a few days sleep also lol
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macross89 19-Sep-22 06:30 AM
I never realized that the use for the probiotic tablets wasn't for raw consumption but rather to make kefir from scratch by adding the bacteria
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JK
Almost considering Mirtazapine just to get a few days sleep also lol
veganpermanently 19-Sep-22 06:31 AM
agomelatine
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veganpermanently
thinking about getting an indoor bike so I can solve aging and solve aging too if u get what I mean
JK 19-Sep-22 06:31 AM
i used to lend my dads indoor trainer for it. damn that was hot
06:31
used some app to cycle against others
06:31
pretty fun actually
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macross89 19-Sep-22 06:32 AM
Rosemary carnosic acid or whatever it's called seems interesting, never tried it yet
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JK
used some app to cycle against others
veganpermanently 19-Sep-22 06:32 AM
nah I just wanna read studies in that state
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veganpermanently
agomelatine
JK 19-Sep-22 06:32 AM
cool, i'll look it up
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veganpermanently
nah I just wanna read studies in that state
JK 19-Sep-22 06:32 AM
haha, well bdnf wise it's a clever move
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veganpermanently 19-Sep-22 06:32 AM
I always start thinking about biohacking on the road
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macross89 19-Sep-22 06:32 AM
Probably the best sleeping stack I can come up with is mirtazapine + phosphatidylserine + magnesium l threonate +, Rosemary carnosic acid
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veganpermanently 19-Sep-22 06:32 AM
then someone almost crashes into me in my dissociative state
06:33
but they fall and I stay on the bike
06:33
⚜️
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macross89 19-Sep-22 06:33 AM
Mirtazapine by itself is enough for me, knocks me the f out
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macross89
Probably the best sleeping stack I can come up with is mirtazapine + phosphatidylserine + magnesium l threonate +, Rosemary carnosic acid
JK 19-Sep-22 06:33 AM
damn, custom nembutal yo
06:34
@veganpermanently what do you consider most important with regards to longevity atm? (edited)
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macross89 19-Sep-22 06:34 AM
I still can't believe that p-serine + Magtein combo sedates the crap out of me (edited)
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JK 19-Sep-22 06:34 AM
not mentioning exercise
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JK
@veganpermanently what do you consider most important with regards to longevity atm? (edited)
veganpermanently 19-Sep-22 06:37 AM
growth pathway homeostasis
06:38
in terms of intervention, fasting mimicking protocol
06:39
in terms of drugs, we need to find ways to make ciclopirox usable orally
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veganpermanently 19-Sep-22 06:47 AM
https://bjorncycles.com/tproduct/1-363076438121-probka
Lightest saddle with 3d printed pad
Lightweight bicycle saddle
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veganpermanently
in terms of drugs, we need to find ways to make ciclopirox usable orally
macross89 19-Sep-22 07:08 AM
What's so special about ciclopirox ? (edited)
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macross89
What's so special about ciclopirox ? (edited)
veganpermanently 19-Sep-22 07:12 AM
50% lifespan increase in C. elegans
07:13
chelates iron, kills fungi unlike DFO which chelates iron but gives you fungi infection
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macross89 19-Sep-22 07:13 AM
C. Elegans? Round worms ?
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macross89
Mirtazapine is an antidepressant worth looking into if you don't want common SSRI side effects like sexual sides
erin 19-Sep-22 07:14 AM
https://rentry.co/atypical-antidepressants
Atypical anti-depressants: Mirtazapine & Nefazodone
AKA Mirtazapine & Nefazodone in a case of multi-model treatment: Pharmacodynamics research & contraindication analysis Summary: Rough research notes on the pharmacodynamics of, and interaction potential for a couple similar atypical anti-depressants, Mirtazapine and Nefazodone, in a case...
07:14
here u go
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veganpermanently 19-Sep-22 07:14 AM
CPX is also a very small molecule and has very good pharmacokinetics unlike DFO but it is toxic to the GI system which should be avoidable with certain preparations
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macross89
C. Elegans? Round worms ?
veganpermanently 19-Sep-22 07:14 AM
noob
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erin 19-Sep-22 07:14 AM
took a bit of time to clean it up (edited)
07:14
but its still a hard read
07:14
maybe ill work it into a cohesive blog post eventually, if i ever do go on it
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veganpermanently 19-Sep-22 07:16 AM
1. easy to synthesize 2. good pharmacokinetics 3. substantial lifespan increase 4. no toxicity 5. no increase in infectious disease risk
07:16
that's all u want from a longevity drug
07:19
also it should be pretty ergogenic and nootropic from what I see
07:19
the erythropoiesis upregulation is dramatic
07:20
which will improve muscular and cerebral blood supply
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erin 19-Sep-22 07:24 AM
updated the document to include relevant parts of my stack
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erin
updated the document to include relevant parts of my stack
macross89 19-Sep-22 07:54 AM
montelukast is a mast cell stabilizer ???
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erin 19-Sep-22 07:56 AM
ye
07:56
love it
07:56
its what finally made all the difference
07:56
i break out in fucking hives every day without it even being on so many antihistamines 😩
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macross89 19-Sep-22 08:01 AM
wtf i had no idea
08:01
I recently started it
08:01
maybe my doctor was listening to me about mast cell lol
08:02
i was telling him I think I need a mast cell stabilizer like ketotifen
08:02
and im having a hard time breathing
08:02
I have asthma
08:02
so I thought he prescribed montelukast for asthma
08:02
didnt know it was a mast cell stabilizer
08:02
shit
08:07
I mean he was, he prescribed my ketotifen but that shit is expensive
08:07
generic is sold out all the time
08:07
here
08:08
but I know a place to get it very cheap
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erin 19-Sep-22 08:08 AM
yeah it treats asthma by stabilizing mast cells...
08:08
which reduces release of hitamine, reducing inflammation it would otherwise cause
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macross89 19-Sep-22 08:08 AM
montelukast is pretty expensive also
08:08
yeah I seem to be sensitive to histamine
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erin 19-Sep-22 08:09 AM
really? its like $10 for a month supply for me
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macross89 19-Sep-22 08:09 AM
when I take NAC I really can't sleep
08:09
and I get irritated
08:09
maybe I have to check again
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erin 19-Sep-22 08:09 AM
and i dont have insurance
08:09
just use coupons
08:10
coupons are often cheaper than using insurance anyway lmao
08:10
like i get a year supply of viagra for like $70
08:10
with a coupon
08:10
when my insurance wont even cover it
08:11
well, when i had insurance
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macross89 19-Sep-22 08:11 AM
do you need viagra as a result of side effects of trazodone or something ?
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erin 19-Sep-22 08:11 AM
HRT
08:12
i dont have much ED problems when having sex
08:12
i take it so i have nocturnal erections
08:12
to stave off penile atrophy and retain the ability to achieve erection
08:12
since estrogen pretty much prevents nocturnal erections in totality (edited)
08:14
male genetalia really doesnt like to function right when in the presence of mostly estrogen 🙃 go figure
08:14
i also use low dose topical testosterone to increase local levels of T there
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macross89 19-Sep-22 08:15 AM
damn that sucks
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erin 19-Sep-22 08:15 AM
yeah im not a fan of it
08:15
considering i like my dick
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macross89 19-Sep-22 08:16 AM
how is your mood since starting hrt
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erin 19-Sep-22 08:16 AM
hugely improved
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macross89 19-Sep-22 08:16 AM
whoops wrong emote
08:16
👍
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erin 19-Sep-22 08:17 AM
it massively improved my self-worth, nearly eliminated dissociation, and gave me a boatload of confidence
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macross89 19-Sep-22 08:17 AM
you have an autoimmune disease ? is that why you take MCAS ?
08:17
i mean
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erin 19-Sep-22 08:17 AM
i have dermatographia
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macross89 19-Sep-22 08:17 AM
montelukast
08:18
oh ok
08:18
I'd imagine you noticed more improvements on montelukast than any of the histamine blockers ?
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erin 19-Sep-22 08:18 AM
which is theoretically a MAST cell condition of the skin
08:18
like, i cant wear tight clothing or it makes me itch
08:19
just sitting for long periods with my back on a chair causes irritation and itching
08:19
rashes, hives, etc.
08:19
the antihistamines help too
08:19
the entire regimen is necessary, unfortunately
08:20
i might eventually replace the fexofenadine with more loratadine though
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macross89 19-Sep-22 08:20 AM
is amphetamine the most costly out of your stack ?
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erin 19-Sep-22 08:20 AM
yes
08:20
$50/mo
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macross89 19-Sep-22 08:20 AM
shits expensive even generic lol
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erin 19-Sep-22 08:20 AM
yep!
08:20
stims all seem like theyre the same price
08:20
even ritalin is $50
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macross89 19-Sep-22 08:20 AM
really ? I would have thought vyvanse and ritaline would be less maybe
08:20
wow
08:21
975869370045722694
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erin 19-Sep-22 08:21 AM
im talking ER formulation tho
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MEE6 BOT 19-Sep-22 08:21 AM
@erin, you have advanced to lvl 6 respect++ emoji_51
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erin 19-Sep-22 08:21 AM
IR is a bit cheaper
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macross89 19-Sep-22 08:21 AM
I think IR is banned in my country
08:21
at least for adderall
08:21
amphetamine
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erin 19-Sep-22 08:21 AM
lol
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macross89 19-Sep-22 08:22 AM
they say because of potential for addiction being likelier
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erin 19-Sep-22 08:22 AM
yeah i hear some european countries hate stims
08:22
i have a friend in poland where amphetamine is entirely banned
08:22
only option is methylphenidate
08:22
and france apparently doesnt believe adult ADD exists
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erin
i also use low dose topical testosterone to increase local levels of T there
Yana 19-Sep-22 08:23 AM
Lmao amazing
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erin 19-Sep-22 08:23 AM
yeah i love my endo, yana
08:24
he even rx'd me BOTH transmasc T AND transfem E2 vials AT THE SAME TIME when i was like YO im an enby and this all estrogen all the time thing kinda sucks sometimes!! (edited)
08:25
unfortunately my brain hates T and going off E2 was a terrible idea
08:25
so i gotta make do and accept that my libido is radically different meow pensiveblob
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macross89
It's crazy to me how brainless jobs that require like 0 intellect education can make so much
Netizenne 19-Sep-22 10:25 AM
They are risking their lives running into great infernos tho
10:26
Also there is the pressure of not letting entire cities burn down when it comes to forest fires
10:27
This lil town Lytton near where I live was completely flattened, not a building spared
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Mabus Tiefsee
from the effects, it sound like itvalso binds to some testosterone receotors?
Netizenne 19-Sep-22 10:30 AM
Just the estrogen beta receptor (ERB) afaik
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Netizenne
Just the estrogen beta receptor (ERB) afaik
veganpermanently 19-Sep-22 10:40 AM
the behavioral effects of testosterone come from erb agonism from it's metabolite 3b androstanedione and the dopamine modulation from AR agonism
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CEO 19-Sep-22 10:43 AM
My head feels so tense
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CEO
My head feels so tense
veganpermanently 19-Sep-22 10:43 AM
I had that yesterday
10:43
lower stims
10:44
also I noticed this happens from GABAergic withdrawal even taurine
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veganpermanently
I had that yesterday
CEO 19-Sep-22 10:46 AM
It happens after I jack off
10:46
Not even trolling
10:46
I need to relax more during the deed
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veganpermanently 19-Sep-22 10:47 AM
sexual headache
10:47
that was the worst I ever felt
10:48
on a mountain fucking a leech doing some breathing exercises on caloric restriction lots of cannabis and coffee
10:48
bad idea
10:49
I thought I'm dead for sure
10:49
I'll die there on that mountain
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veganpermanently
sexual headache
CEO 19-Sep-22 10:50 AM
Yeah exactly this, I also thing it caused me to have some weird bumps on my head
10:50
Thickened skin
10:50
Ridges
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Netizenne 19-Sep-22 10:50 AM
I’ve started biking as far up the mountain as I can and then ditching it when the trails get too steep and beyond my skill level Want to keep exploring despite the roadblock
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Cast
Can dmso be swallowed
Yana 19-Sep-22 10:51 AM
Ye
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Netizenne 19-Sep-22 10:51 AM
Image attachment
10:51
https://open.spotify.com/track/07BVKWiQlIEc5s0Buuq6Du?si=Wo-zQZLPRHe1eGlyIJQcdg
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Netizenne
I’ve started biking as far up the mountain as I can and then ditching it when the trails get too steep and beyond my skill level Want to keep exploring despite the roadblock
veganpermanently 19-Sep-22 10:52 AM
sounds like you were climbing uphill on a downhill trail
10:52
don't do that
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Netizenne 19-Sep-22 10:52 AM
Some of these trails seem like they’re only meant for foot tbh
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Netizenne
Some of these trails seem like they’re only meant for foot tbh
veganpermanently 19-Sep-22 10:53 AM
you wouldn't believe what downhill bikers do
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Netizenne 19-Sep-22 10:53 AM
Also some of them are quite rocky and narrow lil things that ride the sides of cliffs (edited)
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veganpermanently 19-Sep-22 10:53 AM
crazy mofos
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veganpermanently
don't do that
Netizenne 19-Sep-22 10:54 AM
I think I will!!!!!!!!
10:54
(On foot)
10:54
The trail goes under logs and stuff bikers wouldn’t be able to cross
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veganpermanently 19-Sep-22 10:54 AM
well the downhill bikers are idiots for not marking their trails
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Netizenne 19-Sep-22 10:55 AM
Rarely ever see anyone out here anyways, I basically have the hill to myself most of the time
Image attachment
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veganpermanently 19-Sep-22 10:55 AM
plenty of times been exploring shit and then I hear them and jump into the bushes and a second later they zoom by
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Netizenne 19-Sep-22 10:55 AM
Occasionally I see a kid or two riding their bike on the lower trails
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Yana
Ye
Cast 19-Sep-22 03:16 PM
I heard it can cause pneumonia
15:21
I need to psychopath max quickly
15:22
Gotta pull this girl im attracted to (edited)
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Llamamoe 19-Sep-22 03:28 PM
vlorf
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Cast
I need to psychopath max quickly
Llamamoe 19-Sep-22 03:30 PM
pls don't type stuff like this ☠️
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Llamamoe
pls don't type stuff like this ☠️
Cast 19-Sep-22 03:30 PM
Why nigga
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Llamamoe 19-Sep-22 03:31 PM
"psychopath max", "pull this girl", pls
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Cast 19-Sep-22 03:31 PM
I already convinced 2 other people its the path to salvation
15:31
Abandon emotions for infinte confidence
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Netizenne 19-Sep-22 03:31 PM
Llamamoe hello how’d you get here!!!!!
15:32
I think we’ve spoken on my other account (edited)
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Cast 19-Sep-22 03:32 PM
This girl is cute as hell and wants my pp but like i know ill fuck it up if i dont play my cards right
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Netizenne 19-Sep-22 03:32 PM
I asked you about semax maybe
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Cast 19-Sep-22 03:32 PM
Need confidence noots
15:34
emoji_49 im simpin ngl
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MEE6 BOT 19-Sep-22 03:34 PM
@Cast, you have advanced to lvl 8 respect++ emoji_51
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Cast 19-Sep-22 03:35 PM
Like i already thought she was cute but when she called my name with dat level of enthusiasm 😌
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Cast 19-Sep-22 07:57 PM
Absolueldly insane dreams about coding and using neural network language models to make a verbal IQ test with infinite novelty. Type y/N if the question makes sense
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Cast
Absolueldly insane dreams about coding and using neural network language models to make a verbal IQ test with infinite novelty. Type y/N if the question makes sense
ibtisam.midlet 19-Sep-22 10:37 PM
awesome
22:40
pardon, How neural network works?
22:43
I always been interested in full matrix calculation like chess game where computer need to calculate all cascade moves to put his self in best situation possible
22:43
I think PFC works the same
22:47
Just elements replaced with unlimited things like empathy, standards, socially, appetite, sex, and work wanting, advocated by rewards, where dominating reward will have more calculation priorities
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Cast
emoji_49 im simpin ngl
veganpermanently 19-Sep-22 11:30 PM
this variety of psychopath is the worst
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Cast
I already convinced 2 other people its the path to salvation
JK 19-Sep-22 11:33 PM
At least your level of troll sophistication shines through, with every word written bro
23:34
Everybody skepticmaxxin but the two you apparently convinced
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MEE6 BOT 19-Sep-22 11:34 PM
@JK, you have advanced to lvl 7 respect++ emoji_51
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JK
At least your level of troll sophistication shines through, with every word written bro
veganpermanently 19-Sep-22 11:35 PM
he's not trolling bro
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JK 19-Sep-22 11:36 PM
Then he is a lost cause lol
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JK
Then he is a lost cause lol
veganpermanently 19-Sep-22 11:36 PM
yes he's very obsessive about a specific thing for a month or two
23:36
few months ago it was IQ
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JK 19-Sep-22 11:37 PM
If psychopathy is your only way out of fixing inferiority complex
23:37
I have no words man
23:37
Yeah I remember
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CEO 19-Sep-22 11:37 PM
Pure o
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JK 19-Sep-22 11:37 PM
When he violently adopted the dfo mentality also
23:38
Just saying, this guy ends up stabbing his neighbor because his noots aren’t sufficient anymore
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JK
If psychopathy is your only way out of fixing inferiority complex
veganpermanently 19-Sep-22 11:39 PM
Or IQ or whatever. The irony being the obsessive trait makes him unattractive itself
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veganpermanently
Or IQ or whatever. The irony being the obsessive trait makes him unattractive itself
JK 19-Sep-22 11:39 PM
Indeed!
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veganpermanently 19-Sep-22 11:39 PM
But I wouldn't be so quick to psychologize
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JK 19-Sep-22 11:40 PM
Nah, I’m just messing
23:40
Probably a good kid
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veganpermanently 19-Sep-22 11:40 PM
For all we know he wants to improve his life
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JK 19-Sep-22 11:41 PM
Just hilarious the amount of effort he puts into projecting his authority complex, in order to convince himself his on the right path
23:42
I mean, i don’t care what you take or do in order to fix your shit, but I will never understand deliberately nuking your emotions in order to “feel better about existence”
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veganpermanently 19-Sep-22 11:43 PM
I mean if he provided some evidence pointing that APD patient have better lives sure I'd consider
23:43
But all of the evidence I've seen says the otherwise
23:44
And I have experienced unempathetic states and it's not fun nor useful
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JK 19-Sep-22 11:47 PM
Exactly, my own experience is that it’s highly counter productive with regards utilizing motivation/drive in order to achieve whatever you, want to achieve. You also just might end up doing shit you will regret for the rest of your life, when this period ends. But yes take some clopidogrel and go hunt squirrels for all I care
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JK
Exactly, my own experience is that it’s highly counter productive with regards utilizing motivation/drive in order to achieve whatever you, want to achieve. You also just might end up doing shit you will regret for the rest of your life, when this period ends. But yes take some clopidogrel and go hunt squirrels for all I care
veganpermanently 19-Sep-22 11:48 PM
Also I don't think that regret requires emotion at all. The consequences may ruin your life making you regret regardless of your mental state
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JK 19-Sep-22 11:51 PM
IMO regret is often associated with feelings of guilt and shame. I treat regret as an emotion, and empirically i think most do.
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veganpermanently 19-Sep-22 11:51 PM
Why did u mention clopidogrel
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JK 19-Sep-22 11:52 PM
But agree, you might be able to “regret” something like rationally backtracking past behaviors and correlate them with present consequences/results and conclude, it wasn’t a smart move (edited)
23:52
Ah just a joke
23:52
No reason lol
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JK
Ah just a joke
veganpermanently 19-Sep-22 11:54 PM
Roflmao that was my first thought but then I looked up the structure and started looking for offtarget effects
emoji_52 1
23:55
Looks monoaminergic
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Cast 20-Sep-22 12:13 AM
Ngl this was one of my best days yet
00:14
Had a really productive class. Ran into the girl im most attracted to. And the art teacher complimented my work
00:14
Flawless day (edited)
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Cast
Had a really productive class. Ran into the girl im most attracted to. And the art teacher complimented my work
veganpermanently 20-Sep-22 12:15 AM
display your work here
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Cast 20-Sep-22 12:15 AM
Nah
00:15
Im schizo
00:16
But its not good anyways since im just taking art for requirement
00:17
I have weird paranoia that if I show things that occur in my irl life theres a chance I know someone on this server irl and they will recognize it and know my alter ego
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veganpermanently 20-Sep-22 12:18 AM
I get that
00:18
actually I don't
00:18
but mkay
00:19
I get paranoid somehow I'll get doxxed
00:19
what u have is not paranoia
00:19
it's insecurity
00:22
if I was blind it would be exquisite
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Cast 20-Sep-22 12:23 AM
True
00:23
Do you make art?
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veganpermanently 20-Sep-22 12:23 AM
used to
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Cast 20-Sep-22 12:23 AM
I can tell by ur pfp
00:23
Sculptures?
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veganpermanently 20-Sep-22 12:23 AM
I went to art school
00:23
ceramics
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Cast 20-Sep-22 12:23 AM
Ah
00:24
I honeslty thought for a second mine was gonna be the best
00:24
Since others were taking longer
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veganpermanently 20-Sep-22 12:24 AM
u just need practice
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Cast 20-Sep-22 12:25 AM
But then when we all turned our canvases i saw that people had like hypee realistic bottles
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veganpermanently 20-Sep-22 12:25 AM
you seem to have a talent to create an atmosphere
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Cast 20-Sep-22 12:25 AM
Mine was probably average
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veganpermanently 20-Sep-22 12:25 AM
but u need technical knowledge
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Cast 20-Sep-22 12:25 AM
Shit
00:26
I just realized art can be good for getting bitches
00:26
Maybe i do care
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veganpermanently 20-Sep-22 12:26 AM
I had a personal tutor
00:26
my brother gf
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Cast 20-Sep-22 12:26 AM
Oh shi
00:26
Affair?
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veganpermanently
Or IQ or whatever. The irony being the obsessive trait makes him unattractive itself
Netizenne 20-Sep-22 12:27 AM
I like the obsessive behaviour don’t tel them not to get interested in things!!!!
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veganpermanently 20-Sep-22 12:27 AM
lel no I had respect for the guy
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Cast 20-Sep-22 12:27 AM
Good
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veganpermanently 20-Sep-22 12:27 AM
nowadays she runs up to me when she sees me on the street
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Cast 20-Sep-22 12:27 AM
Rlly
00:27
But u cant violate bro code rip
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Netizenne
I like the obsessive behaviour don’t tel them not to get interested in things!!!!
veganpermanently 20-Sep-22 12:27 AM
interest is not the same as obsession
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Cast
But u cant violate bro code rip
veganpermanently 20-Sep-22 12:28 AM
she's wretched now
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Cast 20-Sep-22 12:28 AM
Damn wtf
00:28
Fat?
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Cast
Fat?
veganpermanently 20-Sep-22 12:28 AM
no just senescend
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Cast 20-Sep-22 12:28 AM
Oh
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veganpermanently 20-Sep-22 12:29 AM
that's what alcohol does for u
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Cast 20-Sep-22 12:29 AM
I just realized tho how useful it would be to know art
00:29
Like if you are good that will really impress girls
00:29
But i would need to get good with low commitment
00:29
Because it would just be a side quest for me
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Cast
But i would need to get good with low commitment
veganpermanently 20-Sep-22 12:30 AM
that's not possible
00:30
art is the most intensive process
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veganpermanently
actually I don't
Netizenne 20-Sep-22 12:30 AM
You should send pics of the bike trails you ride sometime!!!!
00:30
I bet it’s so nice there
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veganpermanently
art is the most intensive process
Cast 20-Sep-22 12:30 AM
I bet so
00:30
Unless my Iq was like 150
00:30
Ill never have the talent
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Cast
Unless my Iq was like 150
veganpermanently 20-Sep-22 12:30 AM
it doesn't matter
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Cast 20-Sep-22 12:30 AM
But right now
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veganpermanently 20-Sep-22 12:31 AM
still you need time to develop the technicals
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Cast 20-Sep-22 12:31 AM
I gotta max my own characteristics so I can impress this girl
00:31
Because God is brining us closer
00:32
Rn my skills ars that im ripped, im decent at ___ sport and i can code software. None of which are entertaining to women (edited)
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Cast
I gotta max my own characteristics so I can impress this girl
veganpermanently 20-Sep-22 12:32 AM
in 10 years you'll either be married with children or it won't matter at all
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Cast 20-Sep-22 12:32 AM
Guitar
00:32
I wish i knew and had a nice guitar (edited)
00:33
Its most optimal to not come off as boring so i really need a skil lto show off
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Netizenne
You should send pics of the bike trails you ride sometime!!!!
veganpermanently 20-Sep-22 12:33 AM
I'll start riding in the forest again soon. the ticks have died already probably
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Netizenne 20-Sep-22 12:33 AM
I like to think I can play some pretty decent music but I don’t really interact with enough people irl to ever have the opportunity to share it (edited)
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Cast 20-Sep-22 12:33 AM
Or ill just go the basic route and be the drug guy lol
00:33
Women love drug dealers
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veganpermanently 20-Sep-22 12:34 AM
did you just rat yourself out
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Cast 20-Sep-22 12:34 AM
?
00:34
Yea its gonna be so fuckin easy to impress her actually
00:35
Since I can tell that she would be into hiking on drugs
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veganpermanently 20-Sep-22 12:35 AM
never once did I get laid by impressing a girl
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Cast 20-Sep-22 12:35 AM
Its not just that bro
00:36
Like i dont wanna just fk her and move on
00:36
I wanna date
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veganpermanently 20-Sep-22 12:36 AM
yeah same thing bro
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Cast 20-Sep-22 12:37 AM
Rn tho
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veganpermanently 20-Sep-22 12:37 AM
IME women don't like getting impressed
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Cast 20-Sep-22 12:37 AM
Yea they do
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veganpermanently 20-Sep-22 12:37 AM
makes them feel inferior
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Cast 20-Sep-22 12:37 AM
They dont like when you try to impress them
00:37
But if you are impressive theyll be attracted
00:38
The thing is she was already impressed by my physique
00:38
But
00:38
She doenst really know me well
00:38
Which is why I need to optimize my personality characteristics
00:38
I dont wanna kill her attraction
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Netizenne 20-Sep-22 12:38 AM
Being good at piano or something seems like it’d help you keep her longer rather than gain her to begin with
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veganpermanently 20-Sep-22 12:38 AM
how much relationships have u been in
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Cast 20-Sep-22 12:39 AM
Only 1 bro and it was a highschool relationship lol
00:39
Didnt last long
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veganpermanently 20-Sep-22 12:39 AM
so why do you think you have experience
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Cast 20-Sep-22 12:39 AM
Instinct
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veganpermanently 20-Sep-22 12:39 AM
put that to a test
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Cast 20-Sep-22 12:40 AM
I learned whats wrong with me
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Cast
I learned whats wrong with me
veganpermanently 20-Sep-22 12:40 AM
that you think you know everything when you know almost nothing
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Cast 20-Sep-22 12:40 AM
Thats like one of the big factors of why im trying to psychopath max
00:40
I have bad charisma
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veganpermanently
that you think you know everything when you know almost nothing
Cast 20-Sep-22 12:41 AM
I just know this one specific flaw
00:41
But im thinking about some good noots for confidence
00:42
Adderall seems like a big pick
00:42
Also
00:42
This girl is probably the hottest in this campus and im not even cappin
00:43
And i have good chances with her since she already knows me and was attracted to me before (edited)
00:43
So i cant fuck this oppurtunity up
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veganpermanently 20-Sep-22 12:44 AM
pussy FOMO
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Cast 20-Sep-22 12:45 AM
Wtf is fomo
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veganpermanently 20-Sep-22 12:45 AM
fear of missing out
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Cast 20-Sep-22 12:46 AM
Oh yea true
00:46
But its not a bad thing
00:46
Since im actually speed running my life rn
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veganpermanently 20-Sep-22 12:46 AM
does it gift u a better life or a worse life
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Cast 20-Sep-22 12:47 AM
Better because im doing a bunch of shit to improve myself asap
00:47
So even if it doesnt work out at least ill be in a better state than i was
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veganpermanently 20-Sep-22 12:48 AM
I have no reason to prove you wrong
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Cast 20-Sep-22 12:49 AM
Its not often God gifts me a second chance
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veganpermanently
I have no reason to prove you wrong
Cast 20-Sep-22 12:49 AM
You see she actually approached me first
00:49
We were walking with a group and she was behind me and she said i looked fine and asked for my snapchat
00:50
But
00:50
I blew it
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veganpermanently 20-Sep-22 12:50 AM
u should've
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Cast 20-Sep-22 12:50 AM
Took too long to turn around and respond then my friend came up and asked me for help
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veganpermanently 20-Sep-22 12:50 AM
pull her to the bushes
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Cast 20-Sep-22 12:50 AM
It was hesitation
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veganpermanently 20-Sep-22 12:51 AM
she wanted to fuck u
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Cast 20-Sep-22 12:51 AM
Yea i just didnt expect it lol
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veganpermanently 20-Sep-22 12:51 AM
u want a relationship
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Cast 20-Sep-22 12:51 AM
😔
00:51
You see that doesnt work for me
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veganpermanently 20-Sep-22 12:51 AM
she took 20 dicks in her mouth this summer
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Cast 20-Sep-22 12:51 AM
No
00:52
She has or had a bf
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veganpermanently 20-Sep-22 12:52 AM
sure
00:52
exactly
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Cast 20-Sep-22 12:52 AM
They were on the verge of breaking up when i first met her
00:52
But i could make her just mine
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veganpermanently 20-Sep-22 12:52 AM
and that doesn't tell u anything about her?
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Cast 20-Sep-22 12:53 AM
She doesnt seem like that type of gal
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Cast
But i could make her just mine
veganpermanently 20-Sep-22 12:53 AM
at 20 not at all
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Cast 20-Sep-22 12:53 AM
Nah i could
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Cast
She doesnt seem like that type of gal
veganpermanently 20-Sep-22 12:53 AM
1. monkey branching 2. cheating 3. lying
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Cast 20-Sep-22 12:53 AM
She didnt lie
00:55
But it doesnt matter
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veganpermanently 20-Sep-22 12:55 AM
if everyone knows about the fact her relationship is on the verge of breaking that is outreach
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MEE6 BOT 20-Sep-22 12:55 AM
@veganpermanently, you have advanced to lvl 16 respect++ emoji_51
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Cast 20-Sep-22 12:55 AM
You see she would cheat on him
00:55
She wouldnt cheat on me
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veganpermanently 20-Sep-22 12:55 AM
emoji_50
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Cast 20-Sep-22 12:56 AM
Shes the one i think
00:57
Really low probability i would see her again and yet i did
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veganpermanently 20-Sep-22 12:57 AM
did u invert that weeb pic because you're a blue pilled cuck
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Cast 20-Sep-22 12:57 AM
Wut?
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veganpermanently 20-Sep-22 12:58 AM
emoji_18
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Cast 20-Sep-22 12:58 AM
It just looks better inverted
00:58
Her friend
00:58
Wanted to smash me
00:58
But i turned her advances down
00:58
And she wasnt happy about it
00:59
But honestly
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veganpermanently 20-Sep-22 12:59 AM
now that
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Cast 20-Sep-22 12:59 AM
Maybe i shoukd just start fuckin them
00:59
Because it would be easier to go from there
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veganpermanently 20-Sep-22 12:59 AM
humiliation experts in the chat
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Cast 20-Sep-22 01:00 AM
Yea fuck it
01:00
Ill just sex her and hope she isnt a hoe
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veganpermanently 20-Sep-22 01:00 AM
hope is the dope o the masses
01:01
wear protection
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Cast 20-Sep-22 01:01 AM
@veganpermanently its so inverted these days
01:01
Why tf is it sex firsr then relationship
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veganpermanently 20-Sep-22 01:01 AM
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Cast
Why tf is it sex firsr then relationship
veganpermanently 20-Sep-22 01:02 AM
bcs ppl expect everything and promise nothing
01:02
I agree with u tho
01:02
I'm monogamic AF
01:02
but took me my whole life to realize women are not
01:03
maybe some autistic women are
01:03
but it's too hard to approach them
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Cast 20-Sep-22 01:04 AM
Rip
01:04
They just wanna fuck a bunxh of guys and not commit
01:04
Out of fear
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Cast
They just wanna fuck a bunxh of guys and not commit
veganpermanently 20-Sep-22 01:04 AM
yeah until they can't then they settle with a cuck
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Cast 20-Sep-22 01:05 AM
Sigh
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Cast
Out of fear
veganpermanently 20-Sep-22 01:05 AM
no it's not fear
01:05
it's desire
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Cast 20-Sep-22 01:05 AM
Well ill just fuck her and hope she wants more
01:05
But i would be really good at keeping her in check
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Cast
But i would be really good at keeping her in check
veganpermanently 20-Sep-22 01:05 AM
less put that to a test
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Cast 20-Sep-22 01:06 AM
Yea i will
01:06
I have female dogs
01:06
I know i to keep them in check
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veganpermanently 20-Sep-22 01:06 AM
kek what
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Cast 20-Sep-22 01:06 AM
Through dominance
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veganpermanently 20-Sep-22 01:06 AM
emoji_2
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Cast 20-Sep-22 01:06 AM
She wouldnt cheat on me
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veganpermanently 20-Sep-22 01:06 AM
bruh you should be a stand up artist
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Cast 20-Sep-22 01:06 AM
Nah
01:07
I mwan i could be
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MEE6 BOT 20-Sep-22 01:07 AM
@Cast, you have advanced to lvl 9 respect++ emoji_51
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veganpermanently 20-Sep-22 01:07 AM
your life is pure humor
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Cast 20-Sep-22 01:07 AM
Ive always been the funny sporadic guy
01:07
Mostly when im high but
01:07
Anyways
01:08
I feel like
01:08
Women only cheat on some guys
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veganpermanently 20-Sep-22 01:08 AM
I'm not sure if other people will find the lack of self awareness funny tho
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Cast 20-Sep-22 01:08 AM
I really do think this
01:09
Instinct
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Cast
Women only cheat on some guys
veganpermanently 20-Sep-22 01:09 AM
I never caught a woman cheat
01:09
but
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Cast 20-Sep-22 01:09 AM
U dont have to catch her cheat
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veganpermanently 20-Sep-22 01:09 AM
there's no way you can know
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Cast 20-Sep-22 01:09 AM
Yea there is
01:09
Lots of signs
01:10
And
01:10
She wouldnt cheat on me
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veganpermanently 20-Sep-22 01:10 AM
one girl cheated on me with another girl
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Cast 20-Sep-22 01:10 AM
Wtf
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veganpermanently 20-Sep-22 01:10 AM
broke up with her
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Cast 20-Sep-22 01:10 AM
Damn
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veganpermanently 20-Sep-22 01:10 AM
I think she wanted a threesome but she was being immature
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Cast 20-Sep-22 01:11 AM
Yea cut that hoe off
01:11
The thing is i have plenty of reason to believe i wont be cheated on
01:11
1. My nature. 2. Connection 3. Perception
01:12
My nature is of someone that a girl wouldnt cheat on cant explain this but its a combination of masculinity and soul
01:12
2 is connection
01:13
Because of my nature barely any women are compatible with me unless they have a good nature as well (edited)
01:13
3
01:13
Perception
01:13
I can sense the early signs of losing interest
01:14
I would say it all stems from nature
01:14
Scummy girls who would cheat will never end up in a relationship with me (edited)
01:19
https://www.instagram.com/reel/Cifs9CXJdEP/?igshid=MTA0ZTI1NzA=
01:19
This kind of girl would be perfect for you? @veganpermanently
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Cast
This kind of girl would be perfect for you? @veganpermanently
veganpermanently 20-Sep-22 01:19 AM
send pic
01:19
I don't have ig
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Cast 20-Sep-22 01:20 AM
Image attachment
01:20
Autistic and attractive
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veganpermanently 20-Sep-22 01:20 AM
nah
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Cast 20-Sep-22 01:20 AM
Why
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veganpermanently 20-Sep-22 01:20 AM
maybe when I was in high school
01:20
not my type
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Renard 20-Sep-22 01:20 AM
hello
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Cast 20-Sep-22 01:20 AM
Oh too young
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Renard 20-Sep-22 01:20 AM
I just joined, what is this server about?
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Cast 20-Sep-22 01:20 AM
I dont know how old u are
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Cast
Oh too young
veganpermanently 20-Sep-22 01:20 AM
yeah she's a child
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Cast 20-Sep-22 01:21 AM
Tbh im always fuckin girls 18-25
01:21
Actually
01:21
I take that back
01:21
I just cant comprehend being older and not being attracted to 18 year olds
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Cast
I just cant comprehend being older and not being attracted to 18 year olds
veganpermanently 20-Sep-22 01:22 AM
they have undeveloped bodies and facial structure
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Cast 20-Sep-22 01:22 AM
I guess I cant tell since im 20
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veganpermanently 20-Sep-22 01:23 AM
yeah
01:23
I didn't see that when I was 20 either
01:23
at 25 it slowly becomes more and more apparent
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Cast 20-Sep-22 01:23 AM
Well its good now
01:24
But like personality wise
01:24
U would want a loyal autistic gf?
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veganpermanently 20-Sep-22 01:24 AM
yeah
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Cast 20-Sep-22 01:24 AM
Same ngl
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veganpermanently 20-Sep-22 01:24 AM
quiet, loyal, affectionate
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Cast 20-Sep-22 01:24 AM
Loyal autistic and attractive is the jack pot
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veganpermanently
quiet, loyal, affectionate
Cast 20-Sep-22 01:25 AM
Gonna be a hell of a search
01:25
For me
01:25
I either want that or
01:25
Bpd gf
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veganpermanently 20-Sep-22 01:25 AM
I gave up in 2018
01:25
because I have a very specific taste in terms of looks too
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veganpermanently
I gave up in 2018
Cast 20-Sep-22 01:25 AM
What happened
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Cast
What happened
veganpermanently 20-Sep-22 01:26 AM
I realized the only person I like physically is a bad person
01:26
since then I didn't even see anyone I like
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Cast 20-Sep-22 01:26 AM
Brutal
01:26
I feel that tho
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veganpermanently 20-Sep-22 01:26 AM
like not even online
01:27
I know it's superficial and shallow but I can't help it
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Cast 20-Sep-22 01:27 AM
Its good
01:27
Works out better that way
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veganpermanently 20-Sep-22 01:28 AM
yeah I don't want ugly children
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Cast 20-Sep-22 01:28 AM
My standards arent super high
01:28
But
01:28
I would say
01:28
6-10
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veganpermanently 20-Sep-22 01:28 AM
mine are through the roof
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Cast 20-Sep-22 01:29 AM
Probably because you were an artist lol
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veganpermanently 20-Sep-22 01:29 AM
but if you saw the girl I like you would rate her below average
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Cast 20-Sep-22 01:29 AM
Show me
01:29
Or someone that looks like her
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Cast
Or someone that looks like her
veganpermanently 20-Sep-22 01:29 AM
grimes
01:29
same facial features
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Cast 20-Sep-22 01:30 AM
Elon musks wife?
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Cast
Elon musks wife?
veganpermanently 20-Sep-22 01:30 AM
ex
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Cast 20-Sep-22 01:31 AM
Image attachment
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Renard
I just joined, what is this server about?
ibtisam.midlet 20-Sep-22 01:31 AM
read intents
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Cast
Click to see attachment 🖼️
veganpermanently 20-Sep-22 01:31 AM
kinda
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Cast 20-Sep-22 01:31 AM
Yea shes attractive just not my type
01:32
A bit too masculine in the face for me
01:32
Fuck i really wanna show you the girl im interested in
01:32
Ill find an example
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Cast
A bit too masculine in the face for me
veganpermanently 20-Sep-22 01:34 AM
i like the sharp lines but don't like the bodily atrophy
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Cast 20-Sep-22 01:34 AM
I think she has blue eyes
01:34
Full lips
01:34
Perfect proportions
01:34
Hour glass figure
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veganpermanently
i like the sharp lines but don't like the bodily atrophy
Cast 20-Sep-22 01:34 AM
Sharp lines
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veganpermanently 20-Sep-22 01:34 AM
big lips are mid imo
01:35
feels like suffocation when french kissing
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Cast 20-Sep-22 01:35 AM
No not big lips really
01:35
I have to check hrr insta
01:35
It seems weird but
01:35
I jsut nedd a better mental image
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veganpermanently 20-Sep-22 01:36 AM
Image attachment
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Cast 20-Sep-22 01:37 AM
Whos that
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veganpermanently 20-Sep-22 01:37 AM
- ballpoint nose - thick eyebrows - small face compared to eyes nose and lips
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Cast
Whos that
veganpermanently 20-Sep-22 01:37 AM
grimes
01:38
it's southern slav genetics
01:38
kinda rare still
01:38
like 0.1% girls have these features here
01:38
but nowhere else in the world
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Cast 20-Sep-22 01:38 AM
Similar to what the girl im into looks like
01:38
But diff
01:39
Ill find a similar girl
01:40
Also
01:40
I just realized
01:40
That my chances are prob fucked
01:41
Since shes
01:41
Dual enrolled
01:41
So
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ibtisam.midlet 20-Sep-22 01:41 AM
Image attachment
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Cast 20-Sep-22 01:41 AM
Im competeing with way more dudes then i realized
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ibtisam.midlet
Click to see attachment 🖼️
veganpermanently 20-Sep-22 01:42 AM
musk ruined her
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ibtisam.midlet
Click to see attachment 🖼️
Cast 20-Sep-22 01:42 AM
Looks too mousy for me ngl
01:43
Yea i honestly cant explain what she looks like
01:43
Shes just hot
01:43
But anyways
01:44
I just gotta hope shes not in another relationship and i can pull her in time
01:46
Yea i will
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ibtisam.midlet
read intents
Renard 20-Sep-22 01:50 AM
ok
01:52
Good rules, very well-written
👍 1
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Netizenne
Llamamoe hello how’d you get here!!!!!
Llamamoe 20-Sep-22 01:57 AM
Was invited by friend @erin :0 though I'm not really much into the whole nootropics/neurochem jazz lately
01:58
I think most people are just self-treating undiagnosed or undertreated disorders that healthcare is collectively indifferent to
01:58
Usually based on exceptionally tenuous evidence of efficacy and placebo effect
02:00
The topics are fascinating but of limited value to reason about especially when I already know what my underlying conditions are and just need to fix them
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MEE6 BOT 20-Sep-22 02:00 AM
@Llamamoe, you have advanced to lvl 1 respect++ emoji_51
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Llamamoe 20-Sep-22 02:02 AM
Reading the backscroll, @Cast creeps me the hell out.
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Cast 20-Sep-22 02:03 AM
Got a problem bro?
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Llamamoe 20-Sep-22 02:06 AM
Publicly objectifying and disparaging random women, talking about "pulling" girls, awful magical beliefs rooted in misplaced self-confidence, sound like a dude focused on manipulating girls into sleeping with you instead of having any genuine feelings whatsoever
02:06
It's all weird spook
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Llamamoe
Publicly objectifying and disparaging random women, talking about "pulling" girls, awful magical beliefs rooted in misplaced self-confidence, sound like a dude focused on manipulating girls into sleeping with you instead of having any genuine feelings whatsoever
Cast 20-Sep-22 02:07 AM
U clearly didnt read what I said bro
02:07
Because i said i didnt want a one night stand
02:08
Also ur a little faggot if u think talking about a girls looks is objectification
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Llamamoe 20-Sep-22 02:13 AM
Honestly, do it in PMs and who cares, but publicly discussing it is straight up awful. And not wanting a ONS doesn't say anything about you in my mind
02:14
Thinking that "faggot" is an insult does, on the other hand
02:14
Idk if this is what dudes are usually like but I don't think any girl would feel comfortable with you if they knew this is how you talk about women
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Llamamoe
Idk if this is what dudes are usually like but I don't think any girl would feel comfortable with you if they knew this is how you talk about women
Cast 20-Sep-22 02:17 AM
Ur a women
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Llamamoe 20-Sep-22 02:17 AM
Who knows who I am and does it even matter
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Cast 20-Sep-22 02:18 AM
Yea its called locker room talk. Every guy youve ever talked to talkd about women this way
02:18
Unless theyre gay lol
02:19
Ofc the difference is most men wont bring up a specific girl cuz we competitive like that (edited)
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Cast
Yea its called locker room talk. Every guy youve ever talked to talkd about women this way
Llamamoe 20-Sep-22 02:22 AM
Complete with the path where they don't demonstrate any feelings whatsoever, idolize psychopathy as replacement for confidence, and mention only a girl's looks and other superficial characteristics rather than how they get along and interact?
02:22
Cuz I don't think so, having known a lot of really emotionally intelligent dudes over the years
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Cast 20-Sep-22 02:22 AM
Nah youre misjudging me
02:23
I care more about personality than looks
02:23
But even so
02:24
It doesnt really matter
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veganpermanently 20-Sep-22 02:24 AM
damn now I start to like the guy
02:24
it's so easy to manipulate me
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Cast 20-Sep-22 02:24 AM
Idk why she got so pressed lol
02:25
@Llamamoe youve never talked to your girlfriends about how cute a guy looks? (edited)
02:25
Unless youre an introvert i find that hard to believe (edited)
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veganpermanently 20-Sep-22 02:25 AM
men need to start secret societies
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Llamamoe 20-Sep-22 02:26 AM
You make a lot of assumptions about me
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veganpermanently 20-Sep-22 02:26 AM
because this shit will be illegal in a few
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Cast 20-Sep-22 02:26 AM
Ive made 1 assumption about you
02:26
Youve made 4 of me lol (edited)
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veganpermanently
because this shit will be illegal in a few
Cast 20-Sep-22 02:26 AM
Ikr
02:27
I dont give a shit what anyone says im not censoring myself
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Cast
I dont give a shit what anyone says im not censoring myself
veganpermanently 20-Sep-22 02:27 AM
she didn't realize I'm monk else she would antagonize me
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Cast 20-Sep-22 02:28 AM
Shes just uncomfortable that were looking at other women lol
02:28
Sign of insecurity
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veganpermanently 20-Sep-22 02:29 AM
monks are completely censored dude
02:29
the red pill is still alive and well
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Cast 20-Sep-22 02:29 AM
Im not super red pilled
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veganpermanently 20-Sep-22 02:29 AM
try find a single monk philosopher
02:30
2 years ago they were on fire
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Cast 20-Sep-22 02:30 AM
Rip
02:30
Is david goggins considered a monk?
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veganpermanently 20-Sep-22 02:30 AM
no
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Cast 20-Sep-22 02:31 AM
The issue is people dont like male influence anymore
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veganpermanently 20-Sep-22 02:31 AM
monks are invisible by their very nature
02:31
but the philosophy is very attractive because it's useful
02:31
which is why they needed so hard to censor it
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Cast 20-Sep-22 02:31 AM
Very true
02:32
Monks cant be controlled
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Cast
Shes just uncomfortable that were looking at other women lol
Llamamoe 20-Sep-22 02:32 AM
jfc, you're publicly pointing out what you don't like about conventionally attractive women, in a world where women are already riddled with insecurity because everyone feels entitled to do it
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Cast 20-Sep-22 02:32 AM
Due to their detachment of worldly desires
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Llamamoe 20-Sep-22 02:32 AM
As if they are eyecandy to be talked about and not persons
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Llamamoe
jfc, you're publicly pointing out what you don't like about conventionally attractive women, in a world where women are already riddled with insecurity because everyone feels entitled to do it
Cast 20-Sep-22 02:32 AM
Wahhhhhh
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Llamamoe 20-Sep-22 02:32 AM
You need to have awareness of how the shit you say comes across
02:32
And how it might make people reading it feel
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Cast 20-Sep-22 02:32 AM
This is discord get used to it
02:33
Ill say what i want
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veganpermanently 20-Sep-22 02:34 AM
now I have compassion for the psychopath
02:34
damn it
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Llamamoe 20-Sep-22 02:34 AM
Yeah, because wanting other people to care about other people's feelings is going too far
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MEE6 BOT 20-Sep-22 02:34 AM
@Llamamoe, you have advanced to lvl 2 respect++ emoji_51
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Llamamoe 20-Sep-22 02:34 AM
Self-centered prick
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Cast 20-Sep-22 02:34 AM
Psychopathy is the wave
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Llamamoe
Yeah, because wanting other people to care about other people's feelings is going too far
Cast 20-Sep-22 02:34 AM
Why do u care lol
02:35
U seem riddled with insecurities
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Llamamoe 20-Sep-22 02:35 AM
Because it makes society a better place when people do their best to ensure they don't make anyone feel crap?
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Cast 20-Sep-22 02:35 AM
Because i mentioned two traits of a women totallly unrelated to you that i didnt find attractive
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Cast
U seem riddled with insecurities
Llamamoe 20-Sep-22 02:35 AM
Even if I was, so what? Stop trying to make status plays instead of responding to arguments
02:35
No, it's the entirety of how you communicate that bugs me
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Llamamoe
Yeah, because wanting other people to care about other people's feelings is going too far
veganpermanently 20-Sep-22 02:35 AM
I do care about other people's feelings just not yours
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Llamamoe
Even if I was, so what? Stop trying to make status plays instead of responding to arguments
Cast 20-Sep-22 02:36 AM
Ad hominems lol? 🤣
02:36
Im trying to genuingly understand why you care
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Llamamoe 20-Sep-22 02:36 AM
Also, fun fact, back in my less-compassionate days, I used to argument that psychopaths are the only subgroup of people who should be subjected to death penalty
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veganpermanently 20-Sep-22 02:36 AM
mofos coming to discord to cure low BP
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Llamamoe 20-Sep-22 02:37 AM
Since their mere existence makes society worse
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Llamamoe
Also, fun fact, back in my less-compassionate days, I used to argument that psychopaths are the only subgroup of people who should be subjected to death penalty
Cast 20-Sep-22 02:37 AM
Thats ironic as fuck
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Llamamoe 20-Sep-22 02:37 AM
In contrast to that it's bizarre to come across somebody who wants to be one of those subhuman things
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Cast 20-Sep-22 02:37 AM
🤣
02:38
I misjudged you
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Llamamoe 20-Sep-22 02:38 AM
Anyway I should stop since now I'm starting to feel tempted to troll
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Cast 20-Sep-22 02:38 AM
Nah go on
02:38
Lemme guess
02:38
Got manipulated by ur ex?
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Llamamoe
Anyway I should stop since now I'm starting to feel tempted to troll
veganpermanently 20-Sep-22 02:38 AM
all of the back and forth so far feels like trolling
02:38
to be sincere
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Cast 20-Sep-22 02:39 AM
Yea i wanna be productive ngl
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Cast
Im trying to genuingly understand why you care
Llamamoe 20-Sep-22 02:39 AM
Why do you make this lie? It's obvious that what you are trying to do is to find arguments to undermine my position
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Cast 20-Sep-22 02:39 AM
Probably gonna order some d serine soon and grt an adderall prescription (edited)
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Llamamoe 20-Sep-22 02:39 AM
As if you know I have a point and are aware you cannot refute it, so you instead seek to disparage me as a person
02:40
Ironic for you to be the one to cry "muh ad hominem"
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veganpermanently 20-Sep-22 02:40 AM
finally a blip of pharmacology
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Cast 20-Sep-22 02:40 AM
Fr
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veganpermanently 20-Sep-22 02:40 AM
now shut up about the other stuff
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Cast 20-Sep-22 02:40 AM
I was reading a paper on d serine earlier
02:40
I believe that its more related to fear learning rather than fear extinction
02:41
Which when i thought about it those things are very distinctly different
02:41
From what i read it seems that d serine provides the necessary neurochemical material for amygdala plasticity
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veganpermanently 20-Sep-22 02:41 AM
question is how to quench the oxidative stress from d serine
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Cast 20-Sep-22 02:42 AM
Im not aware of that
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Llamamoe 20-Sep-22 02:42 AM
Isn't fear extinction ultimately conditional upon learning of non-fearful patterns in and of itself?
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Cast 20-Sep-22 02:42 AM
No
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veganpermanently 20-Sep-22 02:42 AM
we should find the MoA of d serine oxidative load increase
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Llamamoe 20-Sep-22 02:43 AM
I remember reading about the notion that the brain doesn't explicitly forget memories, there's only failure to encode, atrophy with time, and being overwritten by new ones
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veganpermanently 20-Sep-22 02:43 AM
then we can prevent it, hopefully without interfering with NMDA activation
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Cast 20-Sep-22 02:43 AM
Hm
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Llamamoe
I remember reading about the notion that the brain doesn't explicitly forget memories, there's only failure to encode, atrophy with time, and being overwritten by new ones
veganpermanently 20-Sep-22 02:43 AM
don't needlessly expand the subject pls
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Cast 20-Sep-22 02:44 AM
Maybe a neuroprotectant?
02:44
Like bromantane
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veganpermanently 20-Sep-22 02:44 AM
bromantane is antioxidant yes
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Cast 20-Sep-22 02:44 AM
Nac maybe
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MEE6 BOT 20-Sep-22 02:44 AM
@Cast, you have advanced to lvl 10 respect++ emoji_51
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veganpermanently 20-Sep-22 02:45 AM
NAC maybe yeah
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Cast 20-Sep-22 02:45 AM
D serine might not even be the best target
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veganpermanently
don't needlessly expand the subject pls
Llamamoe 20-Sep-22 02:45 AM
What does that even mean
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Cast 20-Sep-22 02:45 AM
For psychopathy
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veganpermanently 20-Sep-22 02:45 AM
https://pubmed.ncbi.nlm.nih.gov/21314463/
D-serine treatment induces oxidative stress in rat brain - PubMed
D-serine plays a significant role in neuronal activity, including learning, memory, neuronal migration at developmental stages, and cell-death signaling. It has been also suggested that D-serine can potantiate the neurotoxicity induced by N-methyl-D-aspartate (NMDA) receptor activation due to its co …
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Llamamoe
I remember reading about the notion that the brain doesn't explicitly forget memories, there's only failure to encode, atrophy with time, and being overwritten by new ones
CEO 20-Sep-22 02:45 AM
Changing an old memory with a new one?
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Llamamoe 20-Sep-22 02:46 AM
Think of it as a neural circuit encoding A->hurt being overwritten by learning that A->happy instead
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Cast 20-Sep-22 02:46 AM
Theres a difference tho
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veganpermanently 20-Sep-22 02:46 AM
it is likely it has a bimodal effect on mitochondrial health
02:46
a user has reported better effects from smaller doses
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Cast 20-Sep-22 02:47 AM
I see
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Llamamoe 20-Sep-22 02:47 AM
I doubt you can guess what's happening to the mitochondria based on subjective n=1 effects
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Cast 20-Sep-22 02:47 AM
Macross is getting some soon (edited)
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veganpermanently 20-Sep-22 02:47 AM
kinda reminiscent of the methylnicotineamide aldehyde metabolism effect
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Llamamoe
I doubt you can guess what's happening to the mitochondria based on subjective n=1 effects
veganpermanently 20-Sep-22 02:47 AM
that's not only why I said that
02:48
mitochondria can sense h2o2 and respond hormetically
02:48
in large amounts h2o2 kills the mitochondria obviously
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veganpermanently
mitochondria can sense h2o2 and respond hormetically
Cast 20-Sep-22 02:49 AM
Do you plan on using d serine?
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Cast
Do you plan on using d serine?
veganpermanently 20-Sep-22 02:49 AM
no until we get to the bottom of this oxidative load bullshit
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Llamamoe 20-Sep-22 02:49 AM
I mean, all of this is so extremely hypothetical given most of the murine study effects don't even translate into any impact on humans whatsoever and subjective reports are beyond polluted by placebo/nocebo effects
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veganpermanently 20-Sep-22 02:49 AM
from what I see it will age the brain very quickly
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Llamamoe 20-Sep-22 02:49 AM
I used to be into nootropics chat, but I have become deeply disillusioned with time
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veganpermanently
no until we get to the bottom of this oxidative load bullshit
Cast 20-Sep-22 02:49 AM
The result would be acute neuronal death?
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veganpermanently
from what I see it will age the brain very quickly
Cast 20-Sep-22 02:50 AM
Not good
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Cast
The result would be acute neuronal death?
veganpermanently 20-Sep-22 02:50 AM
damage over time
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Cast 20-Sep-22 02:50 AM
The effects would be globally pronouced in the brain correct?
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Llamamoe 20-Sep-22 02:50 AM
Especially since it seems that almost everything that alters dynamics of neural transmission either increases incidence of neurodegenerative disease or has the potential for long-lasting dysregulation
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Cast 20-Sep-22 02:51 AM
Because if localized to the amygdala. Atrophy in that region would be a gold mine for inducing psychopathic traits
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Cast
The effects would be globally pronouced in the brain correct?
veganpermanently 20-Sep-22 02:51 AM
yes PFC especially
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Cast 20-Sep-22 02:51 AM
That is if the emotional memory role the amygdala plays is not as crucial as thought
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veganpermanently
yes PFC especially
Cast 20-Sep-22 02:51 AM
No go then
02:52
Im looking for a drug that targets just the amygdala. Then via megadosing i would be able to damage it through excitotoxicity
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Cast
Because if localized to the amygdala. Atrophy in that region would be a gold mine for inducing psychopathic traits
Llamamoe 20-Sep-22 02:52 AM
You'd just replicate the blunted affect part of half the mental disorders out there
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MEE6 BOT 20-Sep-22 02:52 AM
@Llamamoe, you have advanced to lvl 3 respect++ emoji_51
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Llamamoe
You'd just replicate the blunted affect part of half the mental disorders out there
Cast 20-Sep-22 02:52 AM
Stimulants
02:53
Molly makes me psychopathic
02:53
Its a crucial part of the equation
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Llamamoe 20-Sep-22 02:54 AM
Last I've read, that's the effect MDMA has on people who are already psychopaths
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Cast 20-Sep-22 02:54 AM
Low serotonin sensitivity
02:54
I probably have the genetic dispostion to become a psychopath
02:55
I just need an epigentic kickstart since my childhood was good
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Llamamoe 20-Sep-22 02:55 AM
It just sounds like you have anxiety/self-esteem issues you should probably deal with in other ways than theorizing about how to damage your brain
02:55
You already come across as a psycho to me
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Llamamoe
It just sounds like you have anxiety/self-esteem issues you should probably deal with in other ways than theorizing about how to damage your brain
Cast 20-Sep-22 02:56 AM
Maybe agmantine ashwaganda and d serine
02:57
Im most pre disposed to becoming a psycho
02:57
My own mother thought i was a psychopath
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Llamamoe 20-Sep-22 02:57 AM
Also what does "low serotonin sensitivity" mean, the serotoninergic system has efferents to half the damn brain and the most receptor types and subtypes of any neurotransmitter, even its breakdown is regionally dependent
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Cast 20-Sep-22 02:58 AM
I think for my brain specifically dopamine
02:58
Llama
02:58
https://en.m.wikipedia.org/wiki/Low_arousal_theory#:~:text=The%20low%20arousal%20theory%20is,state%20of%20abnormally%20low%20arousal.
Low arousal theory
The low arousal theory is a psychological theory explaining that people with attention-deficit hyperactivity disorder (ADHD) and antisocial personality disorder seek self-stimulation by excessive activity in order to transcend their state of abnormally low arousal. This low arousal results in the inability or difficulty to sustain attention on a...
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Llamamoe 20-Sep-22 02:59 AM
I'm just saying, to me it sounds like you're doing the nootropic people's favorite pasttime which is engaging in reducing incredibly complex and inconsistent phenomena to simple factoids that can then be reasoned about, which is not a way to arrive at useful conclusions
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Cast
Maybe agmantine ashwaganda and d serine
veganpermanently 20-Sep-22 02:59 AM
deathist stack
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Llamamoe 20-Sep-22 03:00 AM
As a curious anecdote though,
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Cast 20-Sep-22 03:00 AM
Ill explain my theory but I think adhd and psychopathy are linked via genes. Men who had to hunt had genes like maoa-L and adhd. To reduce stress and increase mobility. Due to the genetic connection and low arousal theory I believe i have this genetic warrior archetype. I need to tap into it
💪🏽 1
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Llamamoe 20-Sep-22 03:00 AM
Before treating my sleep disordered breathing, back when my body was extremely out of whack due to dysautonomia, taking methylphenidate has semi-permanently blunted my emotions
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CEO 20-Sep-22 03:00 AM
Hunter gatherer
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Cast 20-Sep-22 03:01 AM
Psychopaths lose serotonin sensisitivty with age
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Llamamoe 20-Sep-22 03:01 AM
It was an extremely negative experience, traumatic almost, because it just fucked me up in a way that MPH hasn't since I started treating SDB
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Cast 20-Sep-22 03:01 AM
And ive noticed my own serotonin sensistivity is low
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Llamamoe 20-Sep-22 03:01 AM
But afterwards I never had the same emotional genuinity as before
Heartsunken 1
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Llamamoe
Before treating my sleep disordered breathing, back when my body was extremely out of whack due to dysautonomia, taking methylphenidate has semi-permanently blunted my emotions
Cast 20-Sep-22 03:01 AM
Yep
03:01
Stimulants are a great target
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Llamamoe 20-Sep-22 03:01 AM
I find it easy to drop emotion and sink into being cold and calculating
03:01
I just don't because it's abhorrent
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Cast 20-Sep-22 03:02 AM
Im getting adderall and or ritalin soon
03:03
Im worried about affecting my t levels but other than that im excited (edited)
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Cast
Ill explain my theory but I think adhd and psychopathy are linked via genes. Men who had to hunt had genes like maoa-L and adhd. To reduce stress and increase mobility. Due to the genetic connection and low arousal theory I believe i have this genetic warrior archetype. I need to tap into it
Llamamoe 20-Sep-22 03:03 AM
Yeah but ADHD is not a phenotype, it's de facto a deficit. That comes with its share of increased oxidative stress, memory and executive dysfunction, social struggle, elevated rates of neurodegenerative and all-cause morbidity, bla bla
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Cast 20-Sep-22 03:04 AM
Different kind of adhd
03:04
The link between hunter genes is known
03:06
https://youtu.be/WUzr7940kgQ
ADHD Vision
Is ADHD a Disability? (Hunter Gatherer Theory)
03:06
Gonna get a genetic test for maoa L
03:07
But its definetly consistent with all my current attributes (edited)
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Llamamoe 20-Sep-22 03:08 AM
Honestly, ADHD is literally a bundle of shit like a dysfunctional prefrontal cortex, memory encoding failures, increased cogntive fatigue
03:08
It's literally an across-the-board deficit in everything used to self-organize and self-govern
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Llamamoe
It's literally an across-the-board deficit in everything used to self-organize and self-govern
Cast 20-Sep-22 03:10 AM
Differwnt kinds and depends on the person
03:10
My adhd is due to my warrior archetype
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Llamamoe 20-Sep-22 03:10 AM
It's not "paying attention to more things", it's "inability to control and filter attention". A hunter-gatherer with ADHD would be struggling to filter out background noise, to continue paying attention to an identified threat, etc.
03:10
That sounds like a cope
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Cast 20-Sep-22 03:10 AM
Its a primordial form of psychopathy
03:11
If i was abused or lived in the hood i would be a psychopath right now
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Llamamoe
It's not "paying attention to more things", it's "inability to control and filter attention". A hunter-gatherer with ADHD would be struggling to filter out background noise, to continue paying attention to an identified threat, etc.
Cast 20-Sep-22 03:11 AM
Nope
03:11
Did u read the low arousal theory?
03:12
https://en.m.wikipedia.org/wiki/Low_arousal_theory#:~:text=The%20low%20arousal%20theory%20is,state%20of%20abnormally%20low%20arousal
Low arousal theory
The low arousal theory is a psychological theory explaining that people with attention-deficit hyperactivity disorder (ADHD) and antisocial personality disorder seek self-stimulation by excessive activity in order to transcend their state of abnormally low arousal. This low arousal results in the inability or difficulty to sustain attention on a...
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Llamamoe 20-Sep-22 03:12 AM
I've read that and vastly more, I've done multiple deep dives into the possible root causes of ADHD and whether it could be fixed (I think some subtypes can, partially)
03:12
Low arousal theory is just one of multiple theories that "explains" a part of the mechanisms and hails it as a root cause
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Cast 20-Sep-22 03:12 AM
If you see a masculine man with adhd its hunter genes
03:13
If see a fat bitch guy with adhd its asd
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Llamamoe 20-Sep-22 03:13 AM
Did you know that strong masculinity is actually a trait of intra-sexual competition btw, and not even actually linked to being more attractive to women?
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Cast 20-Sep-22 03:13 AM
🤣
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Llamamoe 20-Sep-22 03:14 AM
I've done a shitton of reading into masculinity, femininity, facial and bodily cues of attractiveness, etc.
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veganpermanently 20-Sep-22 03:14 AM
https://www.youtube.com/shorts/t1eDWZyrM_w
JC FREEZE
Sneako Vs Fresh and Fit - ALL REAL MEN ARE RED PILL☠️☠️
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Cast 20-Sep-22 03:14 AM
Lol sneako
03:14
Sneako definetly has hunter genes
03:15
Hes adhd as fuck (edited)
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Llamamoe 20-Sep-22 03:15 AM
And most studies turn up surprising results like women actually preferring androgyny, with masculinity being a cue of dominance related to intrasexual competition
03:15
With substantial cultural variability
03:15
But you wouldn't know that because all that reaches you is filtered by the biases of either the redpill or the incel crowds
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Cast 20-Sep-22 03:16 AM
Who are you bro
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Llamamoe 20-Sep-22 03:16 AM
And being redpill/incel to me is a cue of one thing only
03:16
Oof a man who cares about other men vastly more than about what women actually are like and have to say
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Llamamoe
And most studies turn up surprising results like women actually preferring androgyny, with masculinity being a cue of dominance related to intrasexual competition
veganpermanently 20-Sep-22 03:16 AM
wait
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Cast 20-Sep-22 03:16 AM
Im not red pilled retard
03:16
I dont subscribe to ideologies
03:17
Llama is definetly a feminist lol
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veganpermanently 20-Sep-22 03:17 AM
u disregard animal models and in vitro science yet think that people filling out questionaires is proof of something
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Cast 20-Sep-22 03:17 AM
Or one of those unattractive book girls that resents masculine men since they dont pick her
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veganpermanently
u disregard animal models and in vitro science yet think that people filling out questionaires is proof of something
Cast 20-Sep-22 03:18 AM
🤣
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Llamamoe 20-Sep-22 03:18 AM
What is the use of attempting to label me?
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Cast 20-Sep-22 03:18 AM
I need a biographical perspective on your beliefs
03:18
Because they are so wrong lol
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veganpermanently
u disregard animal models and in vitro science yet think that people filling out questionaires is proof of something
Llamamoe 20-Sep-22 03:19 AM
I don't disregard them, I'm just saying you can find studies identifying fascinating properties for almost every noot out there and in practice 90% of them have zero reliable or appreciable effect
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Cast 20-Sep-22 03:19 AM
"Actually women like andro men and masculinity is uh is like a sign of toxicity and homosexuality" (edited)
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Llamamoe
I don't disregard them, I'm just saying you can find studies identifying fascinating properties for almost every noot out there and in practice 90% of them have zero reliable or appreciable effect
veganpermanently 20-Sep-22 03:19 AM
that's exactly why we're doing this
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Cast 20-Sep-22 03:20 AM
Attractive women fuckin love masculine men
03:21
I can attest from experience
03:21
The only reason they wouldnt is probably because they hate their own attraction lol
03:21
Too much rhetoric
03:21
Theyll always pick them in the end
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veganpermanently 20-Sep-22 03:22 AM
it is so satisfying not having to ever think about that stuff
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Llamamoe 20-Sep-22 03:24 AM
Also on the topic of ADHD x arousal, you might find these two papers interesting: Models of attention-deficit hyperactivity disorder https://sci-hub.se/10.1016/j.beproc.2019.01.001
Abstract One of the most notable aspects of the behavior of individuals with Attention Deficit Hyperactivity Disorder(ADHD) is increased variability in many aspects of their behavior, including response times and attentional focus. Among the many theories of ADHD is one that identifies its material cause as phasic malnutrition of the neurons required to maintain constancy of performance. Of the diverse predictions issuing from this theory, one concerns ubiquitous data: response times and their variance in decision tasks. This paper reviews that behavioral neuroenergetics theory and model, shows how they predict representative data, and suggests their relevance to researchers studying animal models of ADHD
Hyperactivity and sensation seeking as autoregulatory attempts to stabilize brain arousal in ADHD and mania? https://sci-hub.se/10.1007/s12402-014-0144-z
According to the vigilance regulation model, the hyperactivity and sensation seeking observed in overtired children, ADHD and mania may be interpreted as an autoregulatory attempt to create a stimulating environment in order to stabilize vigilance. The unstable regulation of vigilance observed in both mania and ADHD may thus explain the attention deficits, which become especially prominent in monotonous sustained attention tasks. Among the arguments supporting the vigilance regulation model are the facts that destabilizing vigilance (e.g. via sleep deprivation) can trigger or exacerbate symptoms of ADHD or mania, whereas stabilizing vigilance (e.g. via psychostimulants, reducing sleep deficits) alleviates these symptoms.
03:25
I personally hypothesize that many cases of ADHD are caused by sleep disturbances, most notably sleep disordered breathing that goes undiagnosed because Obstructive Sleep Apnea criteria don't catch people on the UARS side of the spectrum, which is where most young people and women are
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MEE6 BOT 20-Sep-22 03:25 AM
@Llamamoe, you have advanced to lvl 4 respect++ emoji_51
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Cast 20-Sep-22 03:25 AM
Many not all
03:26
Adhd has many causes. One of them is warrior genes and thats the type im focused on
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Cast
Attractive women fuckin love masculine men
Llamamoe 20-Sep-22 03:26 AM
Or perhaps your own attraction is partially learned based on which women find you attractive? Masculinity seems to be mainly desirable for ONS type scenarios, from what I've read. Like a once-in-a-while temptation, and largely unrelated to other aspects of sex and romance
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Llamamoe
Or perhaps your own attraction is partially learned based on which women find you attractive? Masculinity seems to be mainly desirable for ONS type scenarios, from what I've read. Like a once-in-a-while temptation, and largely unrelated to other aspects of sex and romance
Cast 20-Sep-22 03:26 AM
Oh yea
03:26
Erin invited you
03:26
So youre liberal?
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Llamamoe 20-Sep-22 03:27 AM
Who knows what I am
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Cast 20-Sep-22 03:27 AM
Social justice archetype book girl?
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Llamamoe
I personally hypothesize that many cases of ADHD are caused by sleep disturbances, most notably sleep disordered breathing that goes undiagnosed because Obstructive Sleep Apnea criteria don't catch people on the UARS side of the spectrum, which is where most young people and women are
veganpermanently 20-Sep-22 03:27 AM
kek that's where you show how noob you are
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Cast 20-Sep-22 03:27 AM
I already have her figured out
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veganpermanently 20-Sep-22 03:27 AM
so many assumptions so little science
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Cast 20-Sep-22 03:28 AM
Or biased science and assumptions
03:28
Shes not worth the attention. Her mindset is already fixed
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Llamamoe 20-Sep-22 03:29 AM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470037/
The Link between Pediatric Obstructive Sleep Apnea (OSA) and Attent...
Obstructive sleep apnea (OSA) is a form of sleep-disordered breathing that affects up to 9.5% of the pediatric population. Untreated OSA is associated with several complications, including neurobehavioral sequelae, growth and developmental delay, cardiovascular ...
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03:29
https://sci-hub.se/10.1016/j.sleep.2006.05.016
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Cast 20-Sep-22 03:29 AM
Ima go do something productive
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Llamamoe 20-Sep-22 03:30 AM
https://sci-hub.se/10.1007/s40368-018-0330-3
03:30
https://sci-hub.se/10.1016/j.ortho.2021.08.005
03:30
Read the above
03:31
Rates of sleep impairment in ADHD are astronomical, and the above paint a very clear picture of cause->effect relationship in at least a subpopulation of patients
03:31
I could keep on linking papers on sleep microarchitecture alterations in ADHD being 1:1 consistent with what is present in SDB, but that'd tell you nothing anyway
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veganpermanently
kek that's where you show how noob you are
Llamamoe 20-Sep-22 03:32 AM
Am I really? I've literally spent years reading about the mechanisms, causes, and alterations found in ADHD.
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Llamamoe
Am I really? I've literally spent years reading about the mechanisms, causes, and alterations found in ADHD.
veganpermanently 20-Sep-22 03:33 AM
the assumption you made has been shown to be the literal opposite
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Cast 20-Sep-22 03:33 AM
All so educated yet all so blind
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Llamamoe 20-Sep-22 03:33 AM
Just check out the papers I linked
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Llamamoe
Just check out the papers I linked
Cast 20-Sep-22 03:34 AM
I want a run down of your beliefs
03:34
Thoughts on working out for gaining muscle and aesthetics? (edited)
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veganpermanently 20-Sep-22 03:36 AM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197028/
Women’s Preference for Masculine Traits Is Disrupted by Images of M...
Women’s preferences for men’s masculinized faces and voices were assessed after women (n = 331) were primed with images of male-on-male aggression, male-on-female aggression, pathogens, and neutral scenes. Male-on-male ...
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03:36
feminism makes you hate masculine men
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Cast 20-Sep-22 03:36 AM
Very true
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veganpermanently 20-Sep-22 03:36 AM
then you project your hatred to the rest of the female populace
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Cast 20-Sep-22 03:36 AM
Socialist? @Llamamoe
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veganpermanently
then you project your hatred to the rest of the female populace
Cast 20-Sep-22 03:37 AM
Its such a terrible ailment really
03:37
Usually attractive women dont fall victim
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Llamamoe 20-Sep-22 03:37 AM
tl;dr: Sleep disturbances are almost universal in ADHD, and sleep loss alone triggers/worsens ADHD symptoms. Deficits in performance are consistent with inability to maintain vigilance(a derivative of restedness), and both hyperactivity and sensation-seeking work to stabilize it(through dopamine spikes and avoiding taxing the same neural circuits). Motivation deficits are consistent with what's in fatigue, and there exists a number of studies demonstrating very high rates of snoring, impaired airways, pediatric apnea in children who have ADHD, with several papers demonstrating significant remission of symptoms with its treatment
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Cast 20-Sep-22 03:38 AM
Thanks for the tldr but we moved on (edited)
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Llamamoe 20-Sep-22 03:38 AM
@veganpermanently @Cast I find it amusing how you insistently try to portray yourselves as beacons of reason when all you do is attempting to learn more about me and make digs at my character/worldviews as an attempt to dismiss what I say
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veganpermanently 20-Sep-22 03:39 AM
https://psycnet.apa.org/record/2016-52090-001
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Cast 20-Sep-22 03:39 AM
We already dismissed what youve been saying
03:40
I want biographical context to understand why you say it
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Llamamoe 20-Sep-22 03:40 AM
sigh
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Llamamoe
@veganpermanently @Cast I find it amusing how you insistently try to portray yourselves as beacons of reason when all you do is attempting to learn more about me and make digs at my character/worldviews as an attempt to dismiss what I say
veganpermanently 20-Sep-22 03:40 AM
I don't dismiss what you say, I analyze it and prove it wrong or accept that it's right
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Llamamoe
sigh
Cast 20-Sep-22 03:40 AM
Poltical opinions
03:40
I know erin is transgender and shes your friend
03:41
Easy to infer you are feminist from that but i dont wanna be wrong about it
03:41
So may you clarify?
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Cast
We already dismissed what youve been saying
Llamamoe 20-Sep-22 03:41 AM
On the basis of not even clicking the studies I linked or considering what I summarized about them? Intriguingly deep thought process.
03:41
I may not. I refuse to identify with any group of people or ideology, as that is not how I form my worldviews
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Cast 20-Sep-22 03:42 AM
Ok ditto
03:42
But i can digurd out your archetype through your beliefs (edited)
03:42
I dont identify as conservative or red pill but many would infer i am as you did earlier
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Llamamoe 20-Sep-22 03:43 AM
I cannot avoid the bias borne of what I am exposed to more/less, but I have enough points of disagreement with every worldview archetype out there that I think I can fairly say I don't align with any
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Cast 20-Sep-22 03:43 AM
So you wouldnt mind me asking a variety of questions pertaining to your beliefs
03:44
Such as views on socialism. Nationalism. Views on social justice. Feminism
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Llamamoe 20-Sep-22 03:44 AM
Given it's obvious that your motivation is primarily to use them as fuel to be dismissive of me, it's a waste of your time as I am disinclined to answer any, as you've surely noticed
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Cast 20-Sep-22 03:44 AM
No
03:44
I genuingly want go understand you
03:45
And we arent gonna get anywhere arguing
03:45
Its better for me to know your roots
03:46
Youre an intellectual person with a world view different from mine
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Llamamoe 20-Sep-22 03:46 AM
My roots are that I have not been a part of society for a very long time
03:47
My intellect is some sort of anomaly because my parents are both stupid and I've been disabled by progressively escalating sleep disordered breathing between 2011-2020
03:47
I've suffered insane amounts of cognitive decline, and even now can barely minimally function thanks to PAP, as I pursue surgical treatment for my deficient airways
03:48
I got into nootropics because I wanted chems to fix my problems
03:48
But then I realized it's a misguided direction
03:48
And most things have causes
03:48
And I am obsessed with reading scientific literature in their pursuit
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Cast 20-Sep-22 03:48 AM
How did you meet erin
03:49
And what characteristics do you have in common with her
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Llamamoe 20-Sep-22 03:50 AM
I genuinely think that most chronic conditions in the world are a product of SDB, gut dysbiosis, metabolic syndromes, and the cumulative over generations impact of environmental pollution(microplastics, chemical plastic additives, NO2, living in elevated CO2, etc). (also forgot to mention, disease burden of postviral syndromes, subpathological infections, etc.) (edited)
03:51
Early life cancer, neurodevelopmental issue, lifelong depression rates aren't skyrocketing on their own
03:51
And are not caused by deficit of psych meds
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Cast 20-Sep-22 03:51 AM
Politically though
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Llamamoe 20-Sep-22 03:52 AM
I don't like to summarize my sociopolitical beliefs without getting into the why of why I hold them
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Llamamoe
I genuinely think that most chronic conditions in the world are a product of SDB, gut dysbiosis, metabolic syndromes, and the cumulative over generations impact of environmental pollution(microplastics, chemical plastic additives, NO2, living in elevated CO2, etc). (also forgot to mention, disease burden of postviral syndromes, subpathological infections, etc.) (edited)
veganpermanently 20-Sep-22 03:52 AM
somewhat
03:52
u know what all mental and chronic disease implicates
03:52
the common denominator
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Llamamoe
I don't like to summarize my sociopolitical beliefs without getting into the why of why I hold them
Cast 20-Sep-22 03:52 AM
I want to know why you find masculinity toxic
03:52
What led you to that mindset
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Llamamoe 20-Sep-22 03:53 AM
If you want to know if I am a socialist, I believe that any and every system is defined by the mechanics of how and what it optimizes, and it's clear what our world optimizes for (profit margins above all)
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Cast 20-Sep-22 03:54 AM
Yep
03:54
Anti captialist
03:54
Now for the feminism confession
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veganpermanently 20-Sep-22 03:54 AM
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-015-0310-y
The many roads to mitochondrial dysfunction in neuroimmune and neur...
Background Mitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson’s disease, schizophrenia, depression, autism, and chronic fatigue syndrome. Discussi...
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03:55
https://www.hindawi.com/journals/omcl/2021/5188306/
Mitochondrial Dysfunction in Chronic Respiratory Diseases: Implicat...
Mitochondrial Dysfunction in Chronic Respiratory Diseases: Implications for the Pathogenesis and Potential Therapeutics: Mitochondria are indispensable for energy metabolism and cell signaling. Mitochondrial homeostasis is sustained with stabilization of mitochondrial membrane potential, balance of mitochondrial calcium, integrity of mitochondri...
03:56
https://www.frontiersin.org/articles/10.3389/fmolb.2021.671908/full
Frontiers | The Role of Mitochondrial Dysfunction in Vascular Disea...
Mitochondrial dysfunction is known to be associated with a wide range of human pathologies, such as cancer, metabolic and cardiovascular diseases. One of the possible ways of mitochondrial involvement in the cellular damage is excessive production of reactive oxygen and nitrogen species (ROS and RNS) that cannot be effectively neutralized by exi...
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Cast
Now for the feminism confession
Llamamoe 20-Sep-22 03:56 AM
Lemme see if I can think of a summary to reduce my worldviews down to.
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veganpermanently 20-Sep-22 03:56 AM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950268/
Role of mitochondrial dysfunction in cancer progression
Deregulated cellular energetics was one of the cancer hallmarks. Several underlying mechanisms of deregulated cellular energetics are associated with mitochondrial dysfunction caused by mitochondrial DNA mutations, mitochondrial enzyme defects, or altered ...
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Cast
Now for the feminism confession
Llamamoe 20-Sep-22 04:04 AM
I believe that humans are not as intrinsically different as most people would like to believe, and that most sociocultural male-vs-female differences are an unhealthy symptom of shitty socioculture, with feminism being a product of the fact that issues affecting women are worse and of nature that directly prompts action, whereas compared to that male socialization inhibits the ability to admit to and progress past the issues plaguing men as doing so would be seen as a "weakness". I don't align with feminism because no matter what anyone else says, there's way too much trauma-driven blanket criticizism/shaming of men and their traits in place of compassion for what shapes them to be the way they are. I see it as a movement that in quest for equality leaves men behind, treating them with the same toxicity it purportedly fights against.
04:06
@veganpermanently I have read a lot about mitochondrial dysfunction, it is definitely a huge target, but IMO a mechanism, not a root cause. Definitely worth treating, but probably not in itself sufficient because it happened for a reason.
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MEE6 BOT 20-Sep-22 04:06 AM
@Llamamoe, you have advanced to lvl 5 respect++ emoji_51
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JK 20-Sep-22 04:06 AM
I have a theory that GRIN2A and SP4, correlates with ancient warrior mentality, and i would like to investigate how gene expression in general contributes to schizophrenia. If anyone ia interested I will be available for one on on sparring, to help you become psychotic. We will probably use imipramine and lithium manipulating aChE, but in the wrong direction as we would like more learned helplessness etc. Not that it has any significance with regards to psychotic tendencies but we just don’t want be self sufficient.
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Llamamoe 20-Sep-22 04:07 AM
You might find this paper interesting, I've not read it but it's insanely comprehensive and reviews a shitton of concepts in brain energy metabolism rescue:https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7948516/
Brain energy rescue: an emerging therapeutic concept for neurodegen...
The brain requires a continuous supply of energy in the form of ATP, most of which is produced from glucose by oxidative phosphorylation in mitochondria, complemented by aerobic glycolysis in the cytoplasm. When glucose levels are limited, ketone bodies ...
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JK 20-Sep-22 04:08 AM
I am positive we are improving the human condition in general, and the above will be an immense evolutionary advantage (edited)
04:09
Oh, and bring your alcar
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Llamamoe
@veganpermanently I have read a lot about mitochondrial dysfunction, it is definitely a huge target, but IMO a mechanism, not a root cause. Definitely worth treating, but probably not in itself sufficient because it happened for a reason.
veganpermanently 20-Sep-22 04:11 AM
it happens because of oxidative stress over time which is increased by lifestyle most notably diet. Low amounts of oxidative stress cause a hormetic response which is why exercise is so beneficial for longevity and chronic disease prevention. My approach is to continually induce the hormetic response while keeping the oxidative load very low independently from the hormesis
04:14
the diet is a problem because many nutrients most notably amino acids like BCAAs and methionine directly cause oxidative stress and modern diets are overflowing with protein availability all the time yet the hormetic cues are low and those people who do induce hormesis from time to time also increase protein intake which cancels much of the benefits. this is why endurance athletes have the best longevity stats - most hormesis and the least protein
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Llamamoe
You might find this paper interesting, I've not read it but it's insanely comprehensive and reviews a shitton of concepts in brain energy metabolism rescue:https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7948516/
veganpermanently 20-Sep-22 04:15 AM
thanks will read it
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veganpermanently
it happens because of oxidative stress over time which is increased by lifestyle most notably diet. Low amounts of oxidative stress cause a hormetic response which is why exercise is so beneficial for longevity and chronic disease prevention. My approach is to continually induce the hormetic response while keeping the oxidative load very low independently from the hormesis
Llamamoe 20-Sep-22 04:18 AM
From what I have read, exercise does a lot more than that, through PPAR agonism, improvements in endothelial function, and muscles being an important organ in their own right. You have to remember that the brain is a separate environment from the periphery, and oxidative stress in muscle fibers doesn't necessarily translate into stress in other organs, esp the brain.
04:19
About diets, I feel like much bigger problems are 1) the prevalence of refined carbs, and 2) loss of periods of fasting
04:20
Fasting in particular appears to be something the human body evolved around, and as far as I've read it confers substantial benefits to longevity and health
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Llamamoe
About diets, I feel like much bigger problems are 1) the prevalence of refined carbs, and 2) loss of periods of fasting
veganpermanently 20-Sep-22 04:20 AM
that is bcs you haven't researched the detrimental effects of amino acids
04:20
the effects of fasting come from reduction in amino acid intake
04:21
which is again hormetic in it's nature
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Llamamoe 20-Sep-22 04:21 AM
And it seems that ketone bodies are an important mediator of its benefits, with exogenous ketones in fact replicating many of the same benefits, even in the absence of switch away from glucose
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veganpermanently 20-Sep-22 04:21 AM
and all of the benefits you mentioned are also downstream of hormetic pathways
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erin 20-Sep-22 04:21 AM
damn llama came in hard lmao
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Llamamoe
And it seems that ketone bodies are an important mediator of its benefits, with exogenous ketones in fact replicating many of the same benefits, even in the absence of switch away from glucose
veganpermanently 20-Sep-22 04:22 AM
methylnicotineamide also replicates much of the benefits of fasting and exercise
04:23
it's a neurotoxin
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erin 20-Sep-22 04:23 AM
love to take neurotoxins
04:23
just like i move to give myself cancer by vaping
04:23
om nom
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erin
love to take neurotoxins
veganpermanently 20-Sep-22 04:23 AM
in small doses it's neurprotective
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erin 20-Sep-22 04:24 AM
dont they say that alcohol protects the heart in small doses too
04:24
until a new study says it doesnt
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veganpermanently 20-Sep-22 04:25 AM
I didn't say all toxins are healthy in small doses
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erin
dont they say that alcohol protects the heart in small doses too
Llamamoe 20-Sep-22 04:25 AM
I think my conclusion on alcohol is "too much financial incentives to trust any of it. Maybe there's a beneficial compound or two in wine or beer, but alcohol is deffo bad for you"
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veganpermanently 20-Sep-22 04:25 AM
I mentioned methylnicotinamide for a reason because it's endogenous and upregulated in low caloric and high energy demand environments
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Llamamoe 20-Sep-22 04:26 AM
Honestly, I think most neurotransmission-altering chems are best avoided if one has the choice
joyous 2
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erin 20-Sep-22 04:26 AM
oh thats interesting
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veganpermanently 20-Sep-22 04:26 AM
https://discord.gg/nsJauYJN
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Llamamoe
Honestly, I think most neurotransmission-altering chems are best avoided if one has the choice
veganpermanently 20-Sep-22 04:27 AM
u should be banned
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erin 20-Sep-22 04:27 AM
yeah llama i dont think thats the vibe for this server
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veganpermanently 20-Sep-22 04:28 AM
emoji_50
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erin 20-Sep-22 04:28 AM
i read a lot of what u said and its rather uhhh
04:28
anti what the server is about
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Llamamoe 20-Sep-22 04:28 AM
Yea I've noticed given @Cast was literally talking about trying to figure out how to excitotoxicity his amygdala
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erin 20-Sep-22 04:29 AM
based
04:29
we inducing ASPD up in here?
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Llamamoe 20-Sep-22 04:30 AM
My impression is that he is a psychopath with confidence/self-esteem issues who idolizes men who are more psychopathic than he is and wants to "psychopathymaxx"
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veganpermanently 20-Sep-22 04:30 AM
why does everyone psychologize Lukesta
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JK 20-Sep-22 04:30 AM
He is not a psychopath
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erin
we inducing ASPD up in here?
Cast 20-Sep-22 04:31 AM
Yep
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JK
He is not a psychopath
Cast 20-Sep-22 04:31 AM
Not yet
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JK 20-Sep-22 04:31 AM
Just a guy with.. shall we say intense focus on optimization
04:31
Yeah next month, you’ll be singing kumbaya and doing ayuascha
04:32
But we were here investigating with you
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veganpermanently 20-Sep-22 04:32 AM
llama really fucking embodied modern day female energy
04:32
10/10 don't ever change queen
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JK 20-Sep-22 04:32 AM
haha
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Cast 20-Sep-22 04:33 AM
Fuck it
04:33
Gonan set up an appointment to get adhd diagnosis today
975869370045722694 1
04:33
Stims here i come
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JK 20-Sep-22 04:34 AM
Good idea
04:34
Don’t kill him bro
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veganpermanently
llama really fucking embodied modern day female energy
Llamamoe 20-Sep-22 04:35 AM
I don't even know what that means
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erin 20-Sep-22 04:36 AM
me either, but really, just revel in the gender affirmation, grl
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Cast
Gonan set up an appointment to get adhd diagnosis today
veganpermanently 20-Sep-22 06:48 AM
dude bad idea
06:50
amphetamine will increase oxidative load in monoaminergic neurons, D serine in glutamatergic neurons and kidney, agmatine in the liver and maybe some brain parts
06:50
stupid stack
06:51
at this point whatever Sirsa recommends do the opposite
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veganpermanently
at this point whatever Sirsa recommends do the opposite
blank 20-Sep-22 07:49 AM
sirsad has clearly stated he doesn't support the use of amphetamine and also just to mention jukesta now "cast" already got banned from nootopics so whatever ideas he has aren't from us as if he ever listened to advice anyways jukesta is just obsessed with self inducing psychopathy and autism while getting high on mdma
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Cast 20-Sep-22 07:54 AM
Image attachment
07:55
My life is gonna start getting way better
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Llamamoe
My impression is that he is a psychopath with confidence/self-esteem issues who idolizes men who are more psychopathic than he is and wants to "psychopathymaxx"
Netizenne 20-Sep-22 08:25 AM
I think it’s post irony
08:25
Like it’s kinda fun to just not treat life so seriously
08:26
Tbh I wouldn’t mind having someone interested in psychopathy, cause even though I don’t want to become one, learning to understand them on a pharmacological scale would be interesting
08:26
Sometimes you need application to motivate
08:27
Jukesta the jesta
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a r c t !^ 20-Sep-22 08:28 AM
Ketty neti
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Netizenne 20-Sep-22 08:28 AM
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a r c t !^
Ketty neti
Netizenne 20-Sep-22 08:28 AM
lainwave
08:28
Hello!!
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a r c t !^ 20-Sep-22 08:29 AM
Did you get neet bucks yet 💸
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Cast
Ill explain my theory but I think adhd and psychopathy are linked via genes. Men who had to hunt had genes like maoa-L and adhd. To reduce stress and increase mobility. Due to the genetic connection and low arousal theory I believe i have this genetic warrior archetype. I need to tap into it
Netizenne 20-Sep-22 08:43 AM
Nah I’m not sure psychos are hunter gatherers. Too r-selected, they might have more likely have arose during agriculture in cities imo (or I guess in really fertile lands). You need good group cohesion in hunter gather tribes. Psycho thrives in places they have endless people to toss, throw away, and move onto new ones. (edited)
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a r c t !^
Did you get neet bucks yet 💸
Netizenne 20-Sep-22 08:44 AM
Not quite despair
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Netizenne
Nah I’m not sure psychos are hunter gatherers. Too r-selected, they might have more likely have arose during agriculture in cities imo (or I guess in really fertile lands). You need good group cohesion in hunter gather tribes. Psycho thrives in places they have endless people to toss, throw away, and move onto new ones. (edited)
Cast 20-Sep-22 08:47 AM
They were raiders
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Llamamoe
Yeah but ADHD is not a phenotype, it's de facto a deficit. That comes with its share of increased oxidative stress, memory and executive dysfunction, social struggle, elevated rates of neurodegenerative and all-cause morbidity, bla bla
Netizenne 20-Sep-22 08:47 AM
Often an early death is part of the phenotype. It’s part of what’s known as being a “fast life history strategist”. It’s just a trade off. Oxytocin and HPA axis controls the epigenetic switch between slow and fast life history strategists. https://www.sciencedirect.com/science/article/pii/S266649762100062X https://www.sciencedirect.com/science/article/pii/S0272735821000283#tf0005 (edited)
Love and longevity: A Social Dependency Hypothesis
Mammals, including humans, are reliant for survival and reproduction on adaptations associated with sociality and physiological investment, which can …
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Developmental programming of oxytocin through variation in early-li...
Despite evidence supporting a role for oxytocin (OT) in regulating social behavior, surprisingly little is known about how this neuropeptide is calibr…
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Cast 20-Sep-22 08:47 AM
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Cast
Its a primordial form of psychopathy
Netizenne 20-Sep-22 08:51 AM
https://emilkirkegaard.dk/en/2022/07/psychotics-are-bad-anti-psychotics-are-good/ ADHD seems to be more predisposed to violent crime than even schizophrenics
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Emil O. W. Kirkegaard
Psychotics are bad, anti-psychotics are good
Remember this guy? His name is Noah Esbensen. Actually, he is not a big deal outside of Denmark, but he made a brief stir in the media by going into a mall in Denmark and shooting people. This kind of thing happens very rarely in Denmark, so it gets a lot of attention. His kill count was terr
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08:52
People with adhd are wack!!!!!!!
08:52
Impulsive and unhinged
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Cast
They were raiders
Netizenne 20-Sep-22 08:54 AM
ADHD were hunter gatherers and raiders
08:54
Image attachment
🤣 3
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Netizenne
ADHD were hunter gatherers and raiders
Cast 20-Sep-22 08:55 AM
Yh
08:56
https://en.m.wikipedia.org/wiki/Low_arousal_theory#:~:text=The%20low%20arousal%20theory%20is,state%20of%20abnormally%20low%20arousal
Low arousal theory
The low arousal theory is a psychological theory explaining that people with attention-deficit hyperactivity disorder (ADHD) and antisocial personality disorder seek self-stimulation by excessive activity in order to transcend their state of abnormally low arousal. This low arousal results in the inability or difficulty to sustain attention on a...
08:56
Read this neti
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Netizenne 20-Sep-22 08:56 AM
Let me catch up on chat first
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Llamamoe
I don't disregard them, I'm just saying you can find studies identifying fascinating properties for almost every noot out there and in practice 90% of them have zero reliable or appreciable effect
Netizenne 20-Sep-22 09:00 AM
What are your thoughts on the methodology of looking through metanalyses on SNPs associated with high IQ and then finding drugs that effect the proteins the same way the genes do?
09:01
I think letting nature do all the design and us just copying what she does is one of the more reliable ways to go about it tbh. Biomimicry
09:01
So much of our technology from airplanes to medicine is based on that approach as is
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Cast
https://en.m.wikipedia.org/wiki/Low_arousal_theory#:~:text=The%20low%20arousal%20theory%20is,state%20of%20abnormally%20low%20arousal
Yana 20-Sep-22 09:09 AM
Is this the canon theory
09:09
Is this what psychiatrists are taught
09:10
I've been assuming so
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Cast
I want to know why you find masculinity toxic
Netizenne 20-Sep-22 09:10 AM
I cant stand masculine looking people, I see them irl and I just can’t help but think of them as evil with all my body even though they could be really nice. Think it could be partly why I took estrogen, hatred of my own masculinity (edited)
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Yana
Is this the canon theory
Cast 20-Sep-22 09:11 AM
I have no idea if its canon
09:11
it just seems right to me
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Netizenne
Click to see attachment 🖼️
ibtisam.midlet 20-Sep-22 09:14 AM
Miku ♡
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blank
sirsad has clearly stated he doesn't support the use of amphetamine and also just to mention jukesta now "cast" already got banned from nootopics so whatever ideas he has aren't from us as if he ever listened to advice anyways jukesta is just obsessed with self inducing psychopathy and autism while getting high on mdma
Yana 20-Sep-22 09:21 AM
What'd he get banned for
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Yana
What'd he get banned for
blank 20-Sep-22 09:27 AM
for being completely unhinged
💀 1
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Cast 20-Sep-22 09:34 AM
I think dark empaths are just high IQ psychopaths
09:34
I dont believe in the distinciton
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Netizenne
Not quite despair
a r c t !^ 20-Sep-22 09:37 AM
🔜🤞
prayer 1
🇨🇦 1
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Netizenne
I cant stand masculine looking people, I see them irl and I just can’t help but think of them as evil with all my body even though they could be really nice. Think it could be partly why I took estrogen, hatred of my own masculinity (edited)
veganpermanently 20-Sep-22 10:43 AM
socially acceptable sexist thing to say
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veganpermanently
socially acceptable sexist thing to say
Cast 20-Sep-22 10:44 AM
lol if it was the opposite people would cry incel
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veganpermanently 20-Sep-22 10:44 AM
emoji_52 1
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Cast
lol if it was the opposite people would cry incel
veganpermanently 20-Sep-22 10:44 AM
yeah buddy
10:45
the statement did motivate me to push harder tomorrow
10:45
also: order a bunch of androgens
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ibtisam.midlet 20-Sep-22 11:20 AM
Someone sent me MTF Bible
11:21
It makes sure that estrogen will work with everything you might ask detailed
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Free Will I Am 20-Sep-22 11:32 AM
hrt.cafe?
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Free Will I Am
hrt.cafe?
ibtisam.midlet 20-Sep-22 11:46 AM
nope
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ibtisam.midlet
Someone sent me MTF Bible
Yana 20-Sep-22 12:22 PM
https://archive.org/details/serial-experiments-lain-episode-1
Serial Experiments Lain Episode 1 : Yasuyuki Ueda : Free Download, ...
Serial Experiments Lain (シリアルエクスペリメンツレイン Shiriaru Ekusuperimentsu Rein) is a science fiction anime series directed...
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veganpermanently
socially acceptable sexist thing to say
Netizenne 20-Sep-22 12:30 PM
It’s just how I feel
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Netizenne
It’s just how I feel
veganpermanently 20-Sep-22 12:31 PM
don't worry I don't believe in sexism
12:31
I was just exposing society's double standards
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Netizenne 20-Sep-22 12:32 PM
My anthropology teacher decided she was gonna cut out a buncha the science to just talk about the social controversy/implication of evolution despair
12:32
I guess it could be kinda interesting
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veganpermanently 20-Sep-22 12:32 PM
isms are invented
12:33
they have nothing to do with ethics
12:34
it gives so much false power to people for no reason
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Cast 20-Sep-22 12:40 PM
https://www.instagram.com/reel/CifY-DIpWR0/?igshid=MTA0ZTI1NzA=
12:45
https://www.instagram.com/reel/CiaikfJD6LP/?igshid=MTA0ZTI1NzA=
12:50
I think ashwaganda + adderall + d serine and mayne agmantine
12:55
Although id need a way to counter d serine oxidativr strss
12:56
For now ashwaganda + adderall seems optimal
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veganpermanently 20-Sep-22 12:56 PM
liver + kidney failure
12:56
and brain damage
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veganpermanently
and brain damage
Cast 20-Sep-22 12:57 PM
How about just ashwaganda and adderall?
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Cast
How about just ashwaganda and adderall?
veganpermanently 20-Sep-22 12:58 PM
adderall is neurotoxic my man
12:58
it increases oxidative stress INSIDE the neuron
12:58
Modafinil however decreases it
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veganpermanently
Modafinil however decreases it
Cast 20-Sep-22 12:59 PM
So moda + addy is actually smart?
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MEE6 BOT 20-Sep-22 12:59 PM
@Cast, you have advanced to lvl 11 respect++ emoji_51
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Cast
So moda + addy is actually smart?
veganpermanently 20-Sep-22 01:00 PM
no because amphetamine reverses the vesicular transporter
13:00
and moda upregulates it
13:00
so taking amph and moda together is like taking amphetamine + the adrenergic sides of moda
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veganpermanently
so taking amph and moda together is like taking amphetamine + the adrenergic sides of moda
Cast 20-Sep-22 01:01 PM
If you were going to take adderall which neuroprotectants would you take?
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Cast
If you were going to take adderall which neuroprotectants would you take?
veganpermanently 20-Sep-22 01:01 PM
I wouldn't take amphetamine
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veganpermanently
liver + kidney failure
Yana 20-Sep-22 01:02 PM
Source on agmatine liver damage? What's the rationale
13:02
The increase in beta oxidation is worrying I guess
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veganpermanently 20-Sep-22 01:02 PM
it's like asking me what I would do if I took rat poison
13:02
dumb question
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a r c t !^ 20-Sep-22 01:03 PM
You retards spend more time discussing cognitive enhancements in Discord than practicing 10x more effective natural enhancements
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Cast 20-Sep-22 01:03 PM
Amphetamine is useful and prescribed to millions
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Yana 20-Sep-22 01:03 PM
Are polyamines naughty? 😳
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a r c t !^ 20-Sep-22 01:03 PM
It’s the same conversation every day
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Cast 20-Sep-22 01:03 PM
I already have adhd (edited)
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a r c t !^ 20-Sep-22 01:03 PM
🧠
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a r c t !^
You retards spend more time discussing cognitive enhancements in Discord than practicing 10x more effective natural enhancements
Yana 20-Sep-22 01:03 PM
Drugs are natural
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veganpermanently 20-Sep-22 01:03 PM
@ibtisam.midlet why the hell did this server suddenly fill up with enhancement haters
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a r c t !^ 20-Sep-22 01:04 PM
Go take meth then Yana
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veganpermanently 20-Sep-22 01:04 PM
who is responsible for this
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a r c t !^ 20-Sep-22 01:04 PM
Ciao
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Cast 20-Sep-22 01:04 PM
Good ridance
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a r c t !^ 20-Sep-22 01:04 PM
Riddance *
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veganpermanently 20-Sep-22 01:04 PM
jeez
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Cast 20-Sep-22 01:04 PM
Anyways back to the topic of discussion
13:04
Im still looking for amygdala targets
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Cast
Amphetamine is useful and prescribed to millions
veganpermanently 20-Sep-22 01:04 PM
so is tramadol
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a r c t !^ 20-Sep-22 01:05 PM
Shut up you pathetic subhumans
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veganpermanently 20-Sep-22 01:05 PM
fentanyl
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a r c t !^ 20-Sep-22 01:05 PM
Just go outside
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Cast 20-Sep-22 01:05 PM
Any idea on some pubmed keywords?
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a r c t !^ 20-Sep-22 01:05 PM
😭
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Cast
Any idea on some pubmed keywords?
veganpermanently 20-Sep-22 01:05 PM
whatever u use it will bring up studies that improve amygdala functionality
13:05
and connection to hippocampus
13:05
which is what you should do
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Cast 20-Sep-22 01:06 PM
I dont think so
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veganpermanently 20-Sep-22 01:06 PM
why
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Cast 20-Sep-22 01:07 PM
Im pretty sure amygdala atrophy is the target
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veganpermanently 20-Sep-22 01:07 PM
like show me a piece of evidence that shows that people with atrophied amygdala have better lives in any capacity
👍 1
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veganpermanently
like show me a piece of evidence that shows that people with atrophied amygdala have better lives in any capacity
Yana 20-Sep-22 01:07 PM
All the studies on meditation will show decreased amygdala activity
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a r c t !^ 20-Sep-22 01:08 PM
None of your lives are objectively good for as long as you sit on Discord all day
13:08
Low IQ retards live better than you idiots
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veganpermanently
like show me a piece of evidence that shows that people with atrophied amygdala have better lives in any capacity
Cast 20-Sep-22 01:08 PM
Atrophied amygdala should be a target for psychopathy and i wrong?
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Cast
Atrophied amygdala should be a target for psychopathy and i wrong?
veganpermanently 20-Sep-22 01:08 PM
ur autistic as shit my boy
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Cast
Although id need a way to counter d serine oxidativr strss
Netizenne 20-Sep-22 01:08 PM
Shorter life is just part of the deal of being a fast life history strategists such a psychopath is
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veganpermanently
ur autistic as shit my boy
Cast 20-Sep-22 01:08 PM
What am i missing?
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a r c t !^ 20-Sep-22 01:08 PM
Grass
💀 1
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Cast
What am i missing?
veganpermanently 20-Sep-22 01:09 PM
u pick a target and go at it full force
13:09
and just assume it will improve your life
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Yana
All the studies on meditation will show decreased amygdala activity
veganpermanently 20-Sep-22 01:10 PM
that statement lacks all nuance
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Cast 20-Sep-22 01:10 PM
Psychopathy is my current target
13:10
Image attachment
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a r c t !^ 20-Sep-22 01:10 PM
Chronically online
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Cast 20-Sep-22 01:10 PM
You know
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a r c t !^ 20-Sep-22 01:10 PM
Why am I in this server
13:10
Fucking retards
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a r c t !^
Shut up you pathetic subhumans
Netizenne 20-Sep-22 01:10 PM
Arct noooo ;__;
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Cast
Click to see attachment 🖼️
veganpermanently 20-Sep-22 01:10 PM
see the difference @Yana
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Cast 20-Sep-22 01:11 PM
Yes
13:11
But
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Netizenne 20-Sep-22 01:11 PM
this is a hobby more than an attempt to self better we just like learning (edited)
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Cast 20-Sep-22 01:11 PM
If i chronically down regulate activity in my amygdala i should be able to induce atrophy
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veganpermanently 20-Sep-22 01:11 PM
meditation is opposite of what this fool wants to do
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Cast
If i chronically down regulate activity in my amygdala i should be able to induce atrophy
Yana 20-Sep-22 01:11 PM
Meditation
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Cast 20-Sep-22 01:11 PM
Also with autophagy
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Yana
Meditation
veganpermanently 20-Sep-22 01:12 PM
why are you so inconsistent in your brilliance
despair 1
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Yana 20-Sep-22 01:12 PM
Do a 10 day meditation retreat is the only nuclear option
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veganpermanently 20-Sep-22 01:12 PM
like one moment you have 200 IQ the other you're barely above average
Wuhhhh 1
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veganpermanently
like one moment you have 200 IQ the other you're barely above average
Yana 20-Sep-22 01:13 PM
Because this conversation is below average
13:13
Studies on meditation show either atrophy of gray matter in the amygdala or reduced functional connectivity with areas like ACC
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Netizenne 20-Sep-22 01:14 PM
omw chat is toxic today Wuhhhh
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Yana 20-Sep-22 01:14 PM
Same difference roughly speaking
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Netizenne 20-Sep-22 01:14 PM
nice!!!!!
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Yana
Because this conversation is below average
veganpermanently 20-Sep-22 01:14 PM
I agree but you should've mentioned something about the difference between negative affect amygdala reactivity and vmPFC-amygdala connection
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Yana
Do a 10 day meditation retreat is the only nuclear option
JK 20-Sep-22 01:14 PM
@Yana Did you participate in a vipassana retreat?
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JK
@Yana Did you participate in a vipassana retreat?
Yana 20-Sep-22 01:14 PM
No sir
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JK 20-Sep-22 01:14 PM
Me neither, i've always wanted to
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Cast 20-Sep-22 01:15 PM
Hmm
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JK 20-Sep-22 01:16 PM
As soon as i'm back in good health, i will probably do it. Or perhaps go back to vajrayana and see what i can gather there (edited)
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veganpermanently 20-Sep-22 01:16 PM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671286/
Impact of short- and long-term mindfulness meditation training on a...
Meditation training can improve mood and emotion regulation, yet the neural mechanisms of these affective changes have yet to be fully elucidated. We evaluated the impact of long- and short-term mindfulness meditation training on the amygdala response ...
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veganpermanently
meditation is opposite of what this fool wants to do
Yana 20-Sep-22 01:16 PM
O shit
13:16
Yes I just saw this. Increased vmPFC-amygdala activity kek
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Yana
Yes I just saw this. Increased vmPFC-amygdala activity kek
veganpermanently 20-Sep-22 01:17 PM
so called emotional processing pathway
13:17
that's why monks have 1000 EQ
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Cast 20-Sep-22 01:17 PM
How do we break this circuit
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veganpermanently 20-Sep-22 01:17 PM
emoji_50
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Cast
How do we break this circuit
veganpermanently 20-Sep-22 01:17 PM
put a roadblock there
13:17
I let it flow
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Cast 20-Sep-22 01:18 PM
No its not my destiny
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Cast
How do we break this circuit
JK 20-Sep-22 01:18 PM
Look if you really want bonkers mentality just do a bunch of dissociatives on the regular
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Cast 20-Sep-22 01:18 PM
Wtf (edited)
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JK 20-Sep-22 01:19 PM
idk megadose Methoxetamine every for rest of your life
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Cast 20-Sep-22 01:19 PM
I just remembered my friends been taking a bunch of ashwaganda and stimulants
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veganpermanently 20-Sep-22 01:19 PM
memantine is meditation in a pill
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Cast 20-Sep-22 01:19 PM
My friends been psychopath maxxing
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veganpermanently
memantine is meditation in a pill
JK 20-Sep-22 01:19 PM
hard to come by these days?
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JK
hard to come by these days?
veganpermanently 20-Sep-22 01:19 PM
I have enough
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JK 20-Sep-22 01:19 PM
Source?
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veganpermanently 20-Sep-22 01:19 PM
emoji_51
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Cast 20-Sep-22 01:20 PM
Doesnt nootropic source have it( not trustworthy i know)
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veganpermanently 20-Sep-22 01:20 PM
worst source
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JK 20-Sep-22 01:20 PM
it's menantine
13:20
or something
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veganpermanently
worst source
Cast 20-Sep-22 01:20 PM
Truly
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veganpermanently 20-Sep-22 01:21 PM
rip scibio
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Cast 20-Sep-22 01:21 PM
Sci bio is coming back
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veganpermanently 20-Sep-22 01:21 PM
yeah it's called swisschems now
13:21
emoji_50
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JK 20-Sep-22 01:22 PM
cosmic is $45.00 for 30 tabs
13:22
go fuck thyself
13:22
memantine and phenylpira should be otc
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Cast 20-Sep-22 01:23 PM
https://botany.bio/wp-content/uploads/2021/10/restricted.svg
13:23
How tf do u bypass this lol
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veganpermanently 20-Sep-22 01:23 PM
I swear memantine is an amino acid on a distant alien planet
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JK 20-Sep-22 01:24 PM
never tried it, and always been keen on trying with long sittings of meditation
13:24
hrv 300 ms
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Cast 20-Sep-22 01:24 PM
https://restricted.science.bio/
Science.bio - Driving Innovative Research in Life Science
Welcome to Science.bio. Our mission is to drive innovative research in nootropic, metabolic and longevity science. We supply new, rare and unusual biochemicals.
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ibtisam.midlet 20-Sep-22 01:25 PM
in respectfull way @Cast @veganpermanently @JK https://discord.com/channels/1001420842179239936/1001422332335767664/1002124443868467220
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JK
never tried it, and always been keen on trying with long sittings of meditation
veganpermanently 20-Sep-22 01:25 PM
yeah it's good for that
13:25
This will also block jealous and enevy which amygadala-mediated bad feeling ended with sirsad banning pax 😳
13:26
emoji_50
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veganpermanently
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671286/
Yana 20-Sep-22 01:27 PM
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MEE6 BOT 20-Sep-22 01:27 PM
@Yana, you have advanced to lvl 8 respect++ emoji_51
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veganpermanently
like one moment you have 200 IQ the other you're barely above average
Yana 20-Sep-22 01:29 PM
Blood sugar
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Yana
Blood sugar
veganpermanently 20-Sep-22 01:29 PM
ye I have that issue as well
13:29
that is unless I ride for 10 hours daily
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Yana
Click to see attachment 🖼️
veganpermanently 20-Sep-22 01:33 PM
what's the difference between group 1 and 3
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veganpermanently
what's the difference between group 1 and 3
Yana 20-Sep-22 01:35 PM
Pretty sure it's the same group
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Yana
Pretty sure it's the same group
veganpermanently 20-Sep-22 01:35 PM
with the opposite response??
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Yana 20-Sep-22 01:35 PM
So very well could be inhibitory projections from vmPFC
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veganpermanently 20-Sep-22 01:36 PM
ohh
13:36
gosh
13:36
I'm retarded
13:39
notice the variability of the samples tho
13:40
goes to show the extent of benefits of meditation
13:41
...for the average meditator
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veganpermanently
goes to show the extent of benefits of meditation
Yana 20-Sep-22 01:41 PM
Ay surely it's adaptogenic
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Yana
Ay surely it's adaptogenic
veganpermanently 20-Sep-22 01:42 PM
in my experience meditation only makes me evil
13:42
if I just let my mind flow on it's own it's a shitshow
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Netizenne 20-Sep-22 01:48 PM
What is the neural basis for varying inclinations to ingroup size?
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MEE6 BOT 20-Sep-22 01:48 PM
@Netizenne, you have advanced to lvl 12 respect++ emoji_51
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Netizenne 20-Sep-22 01:48 PM
I want to know more about the science in/out group dynamics
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Netizenne
What is the neural basis for varying inclinations to ingroup size?
veganpermanently 20-Sep-22 01:49 PM
ingroup size is consistent
13:49
narrow ingroup up to 9 people and that's rare
13:49
most often up to 5
13:50
broad ingroup up to 150 people
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Netizenne 20-Sep-22 01:50 PM
Schizoids and borderline both seem to have the commonality of really small in groups of like two people
schizoid individuals "prefer to make relationships on their own terms and not in terms of the impulses of other people." Failing to attain that, they prefer isolation.[25] In general, friendship among schizoids is usually limited to one person, often also schizoid, forming what has been called a union of two eccentrics; "within it – the ecstatic cult of personality, outside it – everything is sharply rejected and despised".[26] (Wikipedia)
 (edited)
Eyespop 1
13:51
https://en.wikipedia.org/wiki/Schizoid_personality_disorder
Schizoid personality disorder
Schizoid personality disorder (, often abbreviated as SzPD or ScPD) is a personality disorder characterized by a lack of interest in social relationships, a tendency toward a solitary or sheltered lifestyle, secretiveness, emotional coldness, detachment and apathy. Affected individuals may be unable to form intimate attachments to others and sim...
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Netizenne
Schizoids and borderline both seem to have the commonality of really small in groups of like two people
schizoid individuals "prefer to make relationships on their own terms and not in terms of the impulses of other people." Failing to attain that, they prefer isolation.[25] In general, friendship among schizoids is usually limited to one person, often also schizoid, forming what has been called a union of two eccentrics; "within it – the ecstatic cult of personality, outside it – everything is sharply rejected and despised".[26] (Wikipedia)
 (edited)
veganpermanently 20-Sep-22 01:52 PM
why does every psychology article describe my life to a t
13:52
it's like fucken astrology
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veganpermanently
why does every psychology article describe my life to a t
Netizenne 20-Sep-22 01:52 PM
Lmfao frrr
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veganpermanently 20-Sep-22 01:52 PM
stupid ass pseudoscience
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Netizenne 20-Sep-22 01:57 PM
https://elifesciences.org/articles/65582 Lol nucleus accumbens is active when rats engaged in “helping” behaviour
Neural correlates of ingroup bias for prosociality in rats
A distinct neural network, including the nucleus accumbens as a central hub, is active when rats are exposed to trapped ingroup members they had previously helped escape a trap, but not for outgroup members who had not been helped.
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13:57
We must nook it with d-serine
13:57
Lmfao
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Netizenne
https://elifesciences.org/articles/65582 Lol nucleus accumbens is active when rats engaged in “helping” behaviour
veganpermanently 20-Sep-22 01:59 PM
today I opened the door for 4 people
13:59
I noticed sex dependent reward
🤣 1
14:00
opening the door for men feels so satisfying
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veganpermanently
opening the door for men feels so satisfying
CEO 20-Sep-22 02:01 PM
I ordered some lube
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CEO
I ordered some lube
veganpermanently 20-Sep-22 02:02 PM
u is a pervy man
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MEE6 BOT 20-Sep-22 02:02 PM
@veganpermanently, you have advanced to lvl 17 respect++ emoji_51
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Netizenne 20-Sep-22 02:03 PM
Voidedstare
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Yana 20-Sep-22 02:06 PM
I see why you're into r/K-selection theory if it's to maximize having a Great Work
14:06
But you say even people like Newton had r-selected traits that are necessary for (creative) genius?
14:09
According to some sources, neanderthals had lower dunbar's number and social skills (no surprise). But I recall reading about far superior face recognition or something
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14:10
And oxytocin improves this
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Cast 20-Sep-22 02:10 PM
Ive got shit tier facial recognition
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Cast
Ive got shit tier facial recognition
Yana 20-Sep-22 02:10 PM
Realistically I think getting demoxytocin might be a much less evil way at achieving this current project
14:11
Will increase ingroup biases and stuff but make you nice to the object of your affection
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Yana
According to some sources, neanderthals had lower dunbar's number and social skills (no surprise). But I recall reading about far superior face recognition or something
judas 20-Sep-22 02:11 PM
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MEE6 BOT 20-Sep-22 02:11 PM
@judas, you have advanced to lvl 3 respect++ emoji_51
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Yana
Will increase ingroup biases and stuff but make you nice to the object of your affection
JK 20-Sep-22 02:11 PM
How so?
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Cast 20-Sep-22 02:12 PM
So demoxytocin for facial recognition?
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judas 20-Sep-22 02:12 PM
I actually can’t stand the social behavioral tendencies of high oxytocin. At least when recognized in others
14:12
It triggers some subconscious anger in me
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JK
How so?
Yana 20-Sep-22 02:12 PM
Something like this
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📝 2
14:13
#Netzienne
14:13
#Ethnocentrism
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Yana
Something like this
Cast 20-Sep-22 02:14 PM
Whats this pathway for
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Cast
Whats this pathway for
Yana 20-Sep-22 02:15 PM
From @Netizenne
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Cast
Whats this pathway for
judas 20-Sep-22 02:15 PM
Downstream effects of increased oxytocin production
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Yana 20-Sep-22 02:15 PM
Just the effectors of oxytocin. Idk much about it. Things like facial recognition is probably via stuff like this but localized (edited)
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Yana
Something like this
Netizenne 20-Sep-22 02:19 PM
I drew this because I noticed a pattern in all the melanocortin receptors effects causing increased neoteny (youthful traits in adulthood) when antagonized or unactivated. Further reading led me to find that the reason was because oxytocin (which decreases their activity) is associated with longevity and slowed growth. And the reason it’s associated with both of those is because it’s responsible for producing a slow life history strategist phenotype (higher parental investment [therefor a need to live longer after reproduction] but less kids [quality>quantity]). (edited)
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Yana
But you say even people like Newton had r-selected traits that are necessary for (creative) genius?
Yana 20-Sep-22 02:20 PM
@Netizenne thoughts
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Netizenne 20-Sep-22 02:21 PM
Part of being a creative genius like Newton or Darwin was having a willingness to disrupt and challenge the existing social institutions and doctrine
14:22
It’s kinda antisocial
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Netizenne
Part of being a creative genius like Newton or Darwin was having a willingness to disrupt and challenge the existing social institutions and doctrine
Yana 20-Sep-22 02:22 PM
Is this not anti-outgroup, i.e. oxytocin i.e. K-selection
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Netizenne 20-Sep-22 02:23 PM
Newton was an incredibly evil person if you read about how they talked about wanting to torture their family and burn them alive and such. Super neurotic guy, very suggestive of an r-selected phenotype
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judas
I actually can’t stand the social behavioral tendencies of high oxytocin. At least when recognized in others
veganpermanently 20-Sep-22 02:23 PM
nah man I think I know what you mean and it's not what oxy is
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judas
I actually can’t stand the social behavioral tendencies of high oxytocin. At least when recognized in others
JK 20-Sep-22 02:23 PM
Too content?
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veganpermanently
nah man I think I know what you mean and it's not what oxy is
judas 20-Sep-22 02:23 PM
What do you think it is ?
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judas
What do you think it is ?
veganpermanently 20-Sep-22 02:23 PM
being a fake person to make other people like u
14:24
oxy is gang mentality
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veganpermanently
oxy is gang mentality
judas 20-Sep-22 02:24 PM
This is what I was referring to tho
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judas
What do you think it is ?
Yana 20-Sep-22 02:24 PM
I've heard that kind of thing being ascribed to a serotongeric pheno
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judas
This is what I was referring to tho
veganpermanently 20-Sep-22 02:24 PM
that sucks
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Yana
@Netizenne thoughts
Netizenne 20-Sep-22 02:24 PM
Tbh I don’t exactly understand the specifics of Duttons theories, I need to read his books eventually. Dutton thought it took the right mix of both r and K selected traits to be a creative genius. iirc he thought a creative genius is an r-selected individual who comes from a K-selected population. (edited)
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Yana
I've heard that kind of thing being ascribed to a serotongeric pheno
judas 20-Sep-22 02:25 PM
Ah I remember someone referencing this once as well. I’ll have to look into it. But isn’t high Serotonin correlated with increased Oxytocin production as well?
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judas
Ah I remember someone referencing this once as well. I’ll have to look into it. But isn’t high Serotonin correlated with increased Oxytocin production as well?
veganpermanently 20-Sep-22 02:25 PM
yeah
14:25
5HT2A to be more precise
14:26
and I think this is because of dopamine release and subsequent D2 activation
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Netizenne
Tbh I don’t exactly understand the specifics of Duttons theories, I need to read his books eventually. Dutton thought it took the right mix of both r and K selected traits to be a creative genius. iirc he thought a creative genius is an r-selected individual who comes from a K-selected population. (edited)
Netizenne 20-Sep-22 02:26 PM
So the creative genius is genetically K-selected but epigenetically r-selected I think.
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Netizenne
So the creative genius is genetically K-selected but epigenetically r-selected I think.
judas 20-Sep-22 02:26 PM
What about the reverse ?
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Netizenne
Tbh I don’t exactly understand the specifics of Duttons theories, I need to read his books eventually. Dutton thought it took the right mix of both r and K selected traits to be a creative genius. iirc he thought a creative genius is an r-selected individual who comes from a K-selected population. (edited)
Yana 20-Sep-22 02:27 PM
Interesting
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Netizenne 20-Sep-22 02:28 PM
The reasoning is that iq is associated with K-selection but disagreeableness and willingness to engage in the taboo/non-conventional (which is where most of the discoveries are) is more r-selected or something
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judas
What about the reverse ?
Netizenne 20-Sep-22 02:29 PM
Idk I think it might lack willingness to engage in taboo?
14:30
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14:31
Being an epigenetically r-selected but genetically K-selected individual is like using K-selected equipment/hardware to achieve and r-selected goal/program.
14:31
Maybe
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Netizenne
Click to see attachment 🖼️
Netizenne 20-Sep-22 02:32 PM
I like reposting this cause it kinda grounds us in the concepts
14:32
Dutton could be wrong as well is something to consider
14:34
I feel like you need to start getting mathematical about the direction of the population approaching the carrying capacity and stuff to go further it’s this but that’s all way over my head
14:34
Math sucks
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Netizenne
Click to see attachment 🖼️
Yana 20-Sep-22 02:35 PM
IMO the dichotomy ceases being all that elegant once you get to this level of complexity, compared to animalz
14:36
Doesn't seem very overarching and instead subject to individual factors that are nonetheless connected like OT and 5HT and then interaction with diverse environments that people nowadays can do
14:38
I guess nonconformity can be for the greater good if you think it's misdirected, yknow? Seems more like an intelligence thing
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Netizenne 20-Sep-22 02:47 PM
I drank too much coffee, cannot contest, only shake 💀
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Yana
IMO the dichotomy ceases being all that elegant once you get to this level of complexity, compared to animalz
Netizenne 20-Sep-22 02:54 PM
Ya tbh creative geniuses might be of their own niche
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veganpermanently 20-Sep-22 02:55 PM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382759/
Loratadine Alleviates Advanced Glycation End Product-Induced Activa...
Chondrocytes in joint tissue are responsible for the synthesis and degradation of the cartilage matrix. Chondrocytes have been closely linked to the pathogenesis of osteoarthritis and cartilage damage. Targeted drug intervention directed at chondrocyte ...
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Netizenne 20-Sep-22 03:04 PM
https://www.reddit.com/r/bloodborne/comments/358r5r/bloodborne_and_rk_selection_theory_spoilers/?utm_source=share&utm_medium=ios_app&utm_name=iossmf
r/bloodborne - [NSFW] Bloodborne and r/K selection theory [Spoilers]
3 votes and 3 comments so far on Reddit
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Yana
IMO the dichotomy ceases being all that elegant once you get to this level of complexity, compared to animalz
Netizenne 20-Sep-22 03:11 PM
Why so? A key trait of K-selected species are their high plasticity -their high capacity to be shaped by parental investment, culture, and externally derived insights. (edited)
15:11
Still ties so many different things together
15:14
I think a subgroup of autists are excessively K-selected. Lack all instincts to the point where they can’t even feed themselves. They were meant to be part of a tribe where feeding was done as a group at regular intervals others decided and such (edited)
15:16
A related issue raised by this study is that outside the structured environment of family mealtimes, some participants reported forgetting to eat. This was also linked to difficulties with interoception- specifically, detecting hunger or satiety, which is an area which is known to be atypical in autism [40]. Again, autistic people who experience these difficulties may benefit from structured meal plans to avoid reliance on hunger and satiety cues. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715205/
Eating as an autistic adult: An exploratory qualitative study
Although eating difficulties are known to be common in children on the autism spectrum, there is a lack of research on whether these behaviours persist or change into adulthood. Emerging evidence suggests that autistic adults may experience higher levels ...
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Netizenne
A related issue raised by this study is that outside the structured environment of family mealtimes, some participants reported forgetting to eat. This was also linked to difficulties with interoception- specifically, detecting hunger or satiety, which is an area which is known to be atypical in autism [40]. Again, autistic people who experience these difficulties may benefit from structured meal plans to avoid reliance on hunger and satiety cues. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715205/
Netizenne 20-Sep-22 03:16 PM
Exactly as predicted!!!
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Netizenne
Why so? A key trait of K-selected species are their high plasticity -their high capacity to be shaped by parental investment, culture, and externally derived insights. (edited)
Yana 20-Sep-22 03:16 PM
Maybe I'm dumb 975869691522326638 don't know too much about it
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Netizenne 20-Sep-22 03:17 PM
It is the continuation of Malthus and Darwin’s trajectory of tradition (edited)
15:18
Japanese are probably most K selected https://www.nippon.com/en/japan-topics/c05008/japan’s-hikikomori-population-could-top-10-million.html
Japan’s “Hikikomori” Population Could Top 10 Million
The government estimates that Japan has 1.15 million hikikomori, people who have withdrawn from society. But Saitō Tamaki, a leading expert on this matter, suggests that the figure is larger and may eventually rise to above 10 million. He shares his thoughts about causes of the problem and ways of dealing with these shut-ins.
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Netizenne
A related issue raised by this study is that outside the structured environment of family mealtimes, some participants reported forgetting to eat. This was also linked to difficulties with interoception- specifically, detecting hunger or satiety, which is an area which is known to be atypical in autism [40]. Again, autistic people who experience these difficulties may benefit from structured meal plans to avoid reliance on hunger and satiety cues. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715205/
veganpermanently 20-Sep-22 03:19 PM
that's based
15:19
predisposed to intermittent fasting
15:19
very nice
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Netizenne
Japanese are probably most K selected https://www.nippon.com/en/japan-topics/c05008/japan’s-hikikomori-population-could-top-10-million.html
Netizenne 20-Sep-22 03:20 PM
I think they could be people who are reliant on social structures who find themselves without any functional ones (edited)
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veganpermanently
predisposed to intermittent fasting
Netizenne 20-Sep-22 03:21 PM
Me lol I forget to eat a lot Makes me agitated
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Netizenne
I think they could be people who are reliant on social structures who find themselves without any functional ones (edited)
Yana 20-Sep-22 03:21 PM
Well I heard at least japanese Twitter is something else (edited)
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Netizenne
Me lol I forget to eat a lot Makes me agitated
veganpermanently 20-Sep-22 03:21 PM
u have to monk
15:22
time to slip
15:22
gn
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Netizenne 20-Sep-22 03:22 PM
Oh sleep well!!!!!!!!!!!
15:22
Gnnnnn!!!!!!!
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veganpermanently 20-Sep-22 03:22 PM
thankuu
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Netizenne 20-Sep-22 03:22 PM
Sticker
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Yana
Doesn't seem very overarching and instead subject to individual factors that are nonetheless connected like OT and 5HT and then interaction with diverse environments that people nowadays can do
Netizenne 20-Sep-22 03:28 PM
I feel like investigating the roles of how active and passive coping relate to slow and fast life history strategies could return interesting insights. 5HT2a/5HT1a to OT relationship (edited)
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veganpermanently
thankuu
CEO 20-Sep-22 04:51 PM
Thoughts on PEMT gene
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.josh. 20-Sep-22 07:39 PM
Hello ✨
19:39
Would anyone be interested in helping me answer questions on my neuroscience homework
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.josh.
Would anyone be interested in helping me answer questions on my neuroscience homework
Netizenne 20-Sep-22 09:11 PM
Depends if it’s interesting (or within my skill level atleast personnaly lol), what’s it about? (edited)
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Cast 20-Sep-22 10:11 PM
@macross89 what was the logic behind acetaminophen?
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Netizenne 21-Sep-22 12:02 AM
@Yana
"finally showed that intranasal oxytocin (vs matching placebo) reduced analytical reasoning, and increased holistic processing, divergent thinking and creative performance."
Oxytocin basically makes you: Low analytical + high creativity = childlike state of mind Just completely reliant on your parents and pears to tell you how to model your world. You have to keep in mind that the human brain evolved to evaluate which ideas to believe or not based on the fitness they’ll provide -not their objective truth. To a K-selected organism, it is beneficial to just adopt the belief system the tribe uses to maintain social cohesion. This ability to pick up arbitrary and abstract belief schemas is just part of being highly plastic -plastic as in malleable to whatever form needed. Nevertheless K-selected organisms are still more generally adaptive and therefor intelligent on average -even if they’re gift of capacity knowledge is a double sided sword that can lead them astray. Epigenetically r-selected yet genetically k-selected organisms have the equipment for plasticity and general adaptiveness -and a freedom from the constraints of social conformity. I guess this can maybe lead to more eccentric and experimental ways of being just as much as it can ASPD idk. I think r-selected organisms might have more genetic variety and mutation too idk. Dutton just found that by looking through records of great people -they tended to seem r-selected based on personality. r-selected organisms generally tend to evolve hardwired instincts for perfectly reacting to their environment -but if they have the equipment of a brain available they might put it to use. (edited)
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Netizenne
@Yana
"finally showed that intranasal oxytocin (vs matching placebo) reduced analytical reasoning, and increased holistic processing, divergent thinking and creative performance."
Oxytocin basically makes you: Low analytical + high creativity = childlike state of mind Just completely reliant on your parents and pears to tell you how to model your world. You have to keep in mind that the human brain evolved to evaluate which ideas to believe or not based on the fitness they’ll provide -not their objective truth. To a K-selected organism, it is beneficial to just adopt the belief system the tribe uses to maintain social cohesion. This ability to pick up arbitrary and abstract belief schemas is just part of being highly plastic -plastic as in malleable to whatever form needed. Nevertheless K-selected organisms are still more generally adaptive and therefor intelligent on average -even if they’re gift of capacity knowledge is a double sided sword that can lead them astray. Epigenetically r-selected yet genetically k-selected organisms have the equipment for plasticity and general adaptiveness -and a freedom from the constraints of social conformity. I guess this can maybe lead to more eccentric and experimental ways of being just as much as it can ASPD idk. I think r-selected organisms might have more genetic variety and mutation too idk. Dutton just found that by looking through records of great people -they tended to seem r-selected based on personality. r-selected organisms generally tend to evolve hardwired instincts for perfectly reacting to their environment -but if they have the equipment of a brain available they might put it to use. (edited)
Netizenne 21-Sep-22 12:06 AM
r/K selection is a struggle to grasp because it combines so so so soooo many diverse complex concepts. The greatest cognitive challenge yet. Just overflow the head. I must master it. (edited)
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Netizenne 21-Sep-22 12:20 AM
I have not been able to find out if oxytocin is elevated in autists cerebral spinal fluid or not -writing it down here so I remember to tomorrow, gn chat
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Cast 21-Sep-22 12:22 AM
@veganpermanently thoughts on lithium orotate?
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Cast
@veganpermanently thoughts on lithium orotate?
veganpermanently 21-Sep-22 12:23 AM
very nephrotoxic
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CEO
Thoughts on PEMT gene
veganpermanently 21-Sep-22 12:28 AM
necessary evil
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veganpermanently
very nephrotoxic
Cast 21-Sep-22 12:31 AM
a decent target for fear extinction tho ?
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Cast
a decent target for fear extinction tho ?
veganpermanently 21-Sep-22 12:32 AM
go back to IQ mate
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veganpermanently
go back to IQ mate
Cast 21-Sep-22 12:32 AM
thats even more daunting
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Cast
thats even more daunting
veganpermanently 21-Sep-22 12:33 AM
just saying u lack common sense
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Cast 21-Sep-22 12:33 AM
im just pitching ideas
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veganpermanently 21-Sep-22 12:33 AM
destroying your kidneys to become an evil prick doesn't deserve comments
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Cast 21-Sep-22 12:34 AM
all life is minimizing prediction errors and maximizing rewards
00:34
this is a great path for maximizing rewards
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veganpermanently 21-Sep-22 12:35 AM
it's not
00:35
because it's obvious to society
00:36
and your reward depends purely on trust of society if you do this
00:36
so it's stupid
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Netizenne 21-Sep-22 12:36 AM
I would like to learn about fear learning for cptsd-like stuff (edited)
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Cast 21-Sep-22 12:37 AM
Id honestly bet its not so hard to acheive this goal
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veganpermanently 21-Sep-22 12:37 AM
very small percentage of psychopaths are proficient
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Cast 21-Sep-22 12:37 AM
I have a good sense of the necessary drugs
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veganpermanently 21-Sep-22 12:37 AM
and I bet that's not because they're psychopaths
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Cast 21-Sep-22 12:38 AM
social skills themselves are separate from psychopathy. But its much easier to learn social skills when you have no social anxiety
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veganpermanently 21-Sep-22 12:38 AM
social anxiety has nothing to do with psychopathy
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Cast 21-Sep-22 12:38 AM
exactly
00:39
emotions like fear and sadness also have nothing to do with psychopathy
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veganpermanently 21-Sep-22 12:39 AM
I mean psychopathy is not prerequisite to defeating social anxiety
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Cast 21-Sep-22 12:39 AM
it wouldnt be psychopathy if they did
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veganpermanently
I mean psychopathy is not prerequisite to defeating social anxiety
Cast 21-Sep-22 12:39 AM
I know im just messin with ya
00:40
but anyways since you clearly arent going to help me Ill just go on my own path and send some updates on the progesss
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veganpermanently 21-Sep-22 12:40 AM
I just woke up an hour ago
00:40
😛
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Cast 21-Sep-22 12:40 AM
stating with lithium orotate and ashwaganda. After ill get a ritalin prescription and add that to the mix
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Cast
but anyways since you clearly arent going to help me Ill just go on my own path and send some updates on the progesss
veganpermanently 21-Sep-22 12:40 AM
I would help you if you didn't keep suggesting toxic substances
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Cast 21-Sep-22 12:41 AM
sure
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veganpermanently 21-Sep-22 12:41 AM
I said it's a bad target
00:41
but it's a target nonetheless
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Cast 21-Sep-22 12:41 AM
I wont suggest these substances to anyone else
00:41
ill be solely responsible
00:41
for whatever damage may occur to me
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veganpermanently 21-Sep-22 12:41 AM
as always
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Cast 21-Sep-22 12:41 AM
ill just list all the targets I know of right now
00:42
Ashwaganda Agamantine Benzodiazepine Ritalin/Adderall D-serine lithium orotate
00:43
Not suggesting id take any of these but
00:43
Ill mention the role each one provides
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veganpermanently 21-Sep-22 12:43 AM
kek
00:43
that stack will cripple u
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Cast 21-Sep-22 12:44 AM
Ashwaganda and agmantine blunt emotions. Lithium orotate reduces stress via gabaergic signaling. D serine reduces fear learning. Stimulants provide goal oriented drive and additional blunting of stress
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veganpermanently
that stack will cripple u
Cast 21-Sep-22 12:44 AM
You know alternatives?
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Cast
You know alternatives?
veganpermanently 21-Sep-22 12:44 AM
yeah
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Cast 21-Sep-22 12:45 AM
spill the beans
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veganpermanently 21-Sep-22 12:45 AM
My stack quite literally
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veganpermanently
My stack quite literally
Cast 21-Sep-22 12:46 AM
youve been trying to induce psychopathy?
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Cast
youve been trying to induce psychopathy?
veganpermanently 21-Sep-22 12:46 AM
nah
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Cast 21-Sep-22 12:47 AM
whats this stack?
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veganpermanently 21-Sep-22 12:47 AM
I've been trying to beat attention deficits and pessimism
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Cast 21-Sep-22 12:47 AM
well theres a cross over here
00:47
minus the emotional blunting ofc
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veganpermanently 21-Sep-22 12:47 AM
yeah NAC is good for emotional blunting
00:48
but it kinda cancels the euphoric effects of the stack
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Cast 21-Sep-22 12:48 AM
nac should also be anti oxitive?
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veganpermanently 21-Sep-22 12:48 AM
one thing about negative affect is that it makes you immune to deception
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Cast 21-Sep-22 12:48 AM
were you planning on taking it with d serine
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veganpermanently
one thing about negative affect is that it makes you immune to deception
Cast 21-Sep-22 12:48 AM
how so. I also dont see how that a negative (edited)
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Cast
how so. I also dont see how that a negative (edited)
veganpermanently 21-Sep-22 12:49 AM
ppl without NA can't detect deception because they have no response to the red flags
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Cast
how so. I also dont see how that a negative (edited)
veganpermanently 21-Sep-22 12:49 AM
yeah I think high NA is good. but that means high amygdala reactivity
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Cast 21-Sep-22 12:50 AM
oh immune to deception in a bad way?
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Cast
oh immune to deception in a bad way?
veganpermanently 21-Sep-22 12:50 AM
no such thing as being real in a bad way
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Cast 21-Sep-22 12:50 AM
what is NA?
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veganpermanently 21-Sep-22 12:50 AM
negative affect
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Cast 21-Sep-22 12:51 AM
thats no good
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veganpermanently 21-Sep-22 12:51 AM
https://en.wikipedia.org/wiki/Negative_affectivity
Negative affectivity
Negative affectivity (NA), or negative affect, is a personality variable that involves the experience of negative emotions and poor self-concept. Negative affectivity subsumes a variety of negative emotions, including anger, contempt, disgust, guilt, fear, and nervousness. Low negative affectivity is characterized by frequent states of calmness ...
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00:51
read this page
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Cast 21-Sep-22 12:51 AM
I would want to be vigilant to deception
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Cast
I would want to be vigilant to deception
veganpermanently 21-Sep-22 12:51 AM
exactly
00:51
for that u need high amygdala reactivity
00:52
the thing about psychopaths is that they often run pyramid schemes but they also often run under them
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Cast 21-Sep-22 12:52 AM
I bet I can supplement high cognitive empathy to reduce susceptibility to deception
00:52
High IQ seems to amplify psychopathy
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veganpermanently 21-Sep-22 12:53 AM
https://www.youtube.com/watch?v=lCcwn6bGUtU
Kassius
Bitconnect Ceremony (Original) - Carlos The Meme
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Cast 21-Sep-22 12:53 AM
lol I remember that
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veganpermanently 21-Sep-22 12:53 AM
carlos is the epitome of inappropriate affect to deception
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Cast 21-Sep-22 12:53 AM
BITCONNNNNEEECCCTTTT
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veganpermanently 21-Sep-22 12:54 AM
to be honest Lukesta
00:54
I feel no emotional empathy for years
00:54
I can induce it with thoughts
00:55
but I can also make it stop by will
00:55
it's freeing in a way
00:55
but it doesn't provide an edge
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Cast 21-Sep-22 12:55 AM
so that a bit sociopathic?
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veganpermanently 21-Sep-22 12:55 AM
and it's hard to hide it from other people
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Cast 21-Sep-22 12:55 AM
what about fear?
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veganpermanently 21-Sep-22 12:56 AM
I dunno about fear
00:56
I have adrenaline response
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Cast 21-Sep-22 12:56 AM
I think the missing link is dopamine
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veganpermanently 21-Sep-22 12:56 AM
but I don't think I ever feel fear
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Cast 21-Sep-22 12:57 AM
HMm
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veganpermanently 21-Sep-22 12:57 AM
like I can hear my heart jumping but my mind remains still at all times
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Cast 21-Sep-22 12:57 AM
I recall u sort of abused psychs
00:57
have you always been this way?
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veganpermanently 21-Sep-22 12:57 AM
no
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Cast 21-Sep-22 12:57 AM
was it post psychedelic use?
00:58
or do you know the actual cause
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veganpermanently 21-Sep-22 12:58 AM
this happened after cycling microdose pharmahuasca and kanna for a few months
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Cast 21-Sep-22 12:58 AM
kanna
00:58
doesnt that have ashwaganda?
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veganpermanently 21-Sep-22 12:58 AM
I would take pharmahuasca for a few months
00:59
then cycle off for 2 weeks then kanna for a few months
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Cast 21-Sep-22 12:59 AM
I think you have the first part of the equation down
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veganpermanently 21-Sep-22 12:59 AM
after about 6 months I noticed I feel nothing for my friends
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Cast 21-Sep-22 12:59 AM
you just need more dopamine
00:59
anyways yea im taking notes
01:00
was this purposeful emotional blunting @veganpermanently
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Cast
was this purposeful emotional blunting @veganpermanently
veganpermanently 21-Sep-22 01:00 AM
it wasn't pleasant at the time but it was useful because my life was a wreck
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Cast 21-Sep-22 01:01 AM
I think ill get the same thing
01:01
with just ashwaganda
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veganpermanently 21-Sep-22 01:01 AM
doubt it
01:01
kanna has a peculiar pharmacology
01:01
and pharmahuasca as well
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Cast 21-Sep-22 01:02 AM
Do you think pharamahuasca restructured the brain to allow for kanna to make the changes permanent?
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Cast
Do you think pharamahuasca restructured the brain to allow for kanna to make the changes permanent?
veganpermanently 21-Sep-22 01:02 AM
possibly
01:03
pharmahuasca would induce a state where I was able to pay attention to very small details and predict short term future and react
01:04
like conscious intuition hard to describe
01:04
high vigilance definitely
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Cast 21-Sep-22 01:04 AM
ah
01:04
kanna increases serotonin levels
01:05
you probably fried your serotonin sensitivity (edited)
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veganpermanently 21-Sep-22 01:05 AM
yeah but the MoA is what matters
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Cast 21-Sep-22 01:06 AM
Ill be getting some kanna
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veganpermanently 21-Sep-22 01:06 AM
I would get high from 0.1 g of mushrooms
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veganpermanently
I would get high from 0.1 g of mushrooms
Cast 21-Sep-22 01:06 AM
jesus
01:06
if you took ritalin or adderall rn you would be a psychopath
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veganpermanently 21-Sep-22 01:07 AM
I take modafinil sometimes
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Cast 21-Sep-22 01:07 AM
notice any increased risk taking behavior?
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veganpermanently 21-Sep-22 01:07 AM
it doesn't seem as a risk when I'm on it roflmao
01:07
but yeah
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Cast 21-Sep-22 01:08 AM
hm
01:08
yea so I figured out the stack so far
01:09
Lithium orotate or nac?
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Cast
Lithium orotate or nac?
veganpermanently 21-Sep-22 01:09 AM
nac
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Cast 21-Sep-22 01:10 AM
alr
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Cast 21-Sep-22 01:48 AM
Should be getring the shit tommorow
01:48
I need a confidence badly since im planning on finding this girl
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veganpermanently 21-Sep-22 01:49 AM
if I could give advice to my 20 old self
01:50
I would say 1. stop smoking weed 2 stop exposing yourself to women needlessly 3. spend more time learning 4. find ways to earn more 5. ????
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Cast 21-Sep-22 01:51 AM
1. Yes 2. Im not promiscuous 3. Good chunk of my dat 4. Definetly looking into this
01:53
I got my plan set up
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veganpermanently 21-Sep-22 01:53 AM
I was never promiscuous
01:54
I was looking for a wife
01:54
little did I know
01:54
no such thing as a wife at 20 yrs old
01:55
you just play your mind
01:55
you say you want a wife and that she's the one
01:55
but deep down you know you're both gonna get tired of the relationship within 2 yrs
😂 1
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Cast 21-Sep-22 01:57 AM
Going to go to the sofa thats near the hallway she walks through at the same time i saw her last. Dig my nose into a book and look busy. When she gets close ill act mildly suprised. Oh hey . Hows it goin. Then ill follow up with I take it your __ now. In which she replies yea. Then i say oh hows that going for ya. After that i will then say you look like youre in a hurry i dont wanna keep ya much longer. Then ill say id love to catch up sometime, can i have your snap? Then i hand her my phone and while shes typing it in ill compliment on her new hair style.
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MEE6 BOT 21-Sep-22 01:57 AM
@Cast, you have advanced to lvl 12 respect++ emoji_51
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Cast 21-Sep-22 01:58 AM
Short and simple interaction in which i should be capable of maintaining control over
01:58
The execution is going to be the hard part
01:58
Ill probably take a large dose of fulvic humic acid
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veganpermanently 21-Sep-22 02:02 AM
02:03
somebody mock this motherfucker this is out of my capability
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veganpermanently
somebody mock this motherfucker this is out of my capability
Cast 21-Sep-22 02:04 AM
Itll work
02:04
If it doesnt work nothing would lol
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veganpermanently 21-Sep-22 02:04 AM
imagine planning out your interaction with a pitiful little girl
02:05
I did think like this once
02:05
WHEN I WAS 12 yrs old
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veganpermanently
imagine planning out your interaction with a pitiful little girl
Cast 21-Sep-22 02:05 AM
02:05
Psychopath mindset
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Cast
Psychopath mindset
veganpermanently 21-Sep-22 02:05 AM
this is how you create social anxiety not psychopathy
02:06
you're way too old for this shit
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Cast 21-Sep-22 02:06 AM
Ok if it works
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JK 21-Sep-22 02:06 AM
Vegan is right, at 20 you most likely are better of initiating random relationships and learning to communicate properly (edited)
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Cast 21-Sep-22 02:06 AM
U wanna bet on it?
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JK 21-Sep-22 02:07 AM
Don’t plan it out, it’s all fluent (edited)
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JK
Vegan is right, at 20 you most likely are better of initiating random relationships and learning to communicate properly (edited)
veganpermanently 21-Sep-22 02:07 AM
he should already have some experience not necessarily with relationships but casually approaching people
02:07
this is just retarded
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JK 21-Sep-22 02:07 AM
Also takes away the magical aspect of it imo
02:07
Yeah
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Cast 21-Sep-22 02:08 AM
I think having a plan is better
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JK 21-Sep-22 02:08 AM
Plan for adaption
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veganpermanently 21-Sep-22 02:08 AM
By 20 I was already in 3 long term relationships got down with a dozen women approached a million strangers
02:08
only approaching my first girl I had a plan
02:08
guess what
02:08
it didn't work out
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JK 21-Sep-22 02:09 AM
Seriously Jukesta. You can plan as much as you want, but omens of the day you are initiating a relationship with another human
02:09
It’s not an NPC
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veganpermanently 21-Sep-22 02:09 AM
exactly
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Cast 21-Sep-22 02:09 AM
Yea i know
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veganpermanently 21-Sep-22 02:09 AM
one tip
02:09
if you're scared of approaching women
02:09
try approach men no homo
02:09
it's kind of the same thing
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JK 21-Sep-22 02:10 AM
^^
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Cast 21-Sep-22 02:10 AM
Another man actually approached me casually my first day
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JK 21-Sep-22 02:10 AM
I enjoy making male friend
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veganpermanently 21-Sep-22 02:10 AM
but the risk of rejection is almost null so it won't tank your self esteem
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Cast 21-Sep-22 02:10 AM
I dont think id be rejected
02:10
She already liked me before
02:11
But i mean
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veganpermanently 21-Sep-22 02:11 AM
that stuff changes bruh
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Cast 21-Sep-22 02:11 AM
Its possible if she already got in another relationship
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veganpermanently 21-Sep-22 02:11 AM
if u rejected her she will reject her now unless she's really emotionally mature and you know how to finness the shit out of it
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JK 21-Sep-22 02:11 AM
Just be yourself man, you get a relationship with someone and as soon as the persona falls away, it’s all chaotic
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veganpermanently
if u rejected her she will reject her now unless she's really emotionally mature and you know how to finness the shit out of it
Cast 21-Sep-22 02:12 AM
Ig but
02:12
I think its gonna work out
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JK 21-Sep-22 02:13 AM
Well, damn then go get her
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Cast 21-Sep-22 02:13 AM
My stack is coming today but i wont have time so ill have to be sober
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JK 21-Sep-22 02:13 AM
Report back after victory!!
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Cast 21-Sep-22 02:13 AM
Ye for sure
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JK 21-Sep-22 02:13 AM
Full support
02:13
U got this
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Cast 21-Sep-22 02:14 AM
If i dont approach ill never know
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JK 21-Sep-22 02:14 AM
That’s the proper attitude
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veganpermanently 21-Sep-22 02:15 AM
I never regretted not approaching a woman in my life
02:15
I did regret lots of relationships tho
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Cast 21-Sep-22 02:15 AM
Lol imagine if she just asks for my snap
02:16
I bet thats a possibility
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veganpermanently 21-Sep-22 02:16 AM
bad choices
02:16
so many ignored red flags
02:17
u know love is like a delusional state
02:17
PFC dysfunction
👍 1
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Cast 21-Sep-22 02:17 AM
Yea
02:17
Hmm
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veganpermanently 21-Sep-22 02:18 AM
I had the wrong older men in my life
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JK 21-Sep-22 02:18 AM
Possessed by in inner image
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veganpermanently 21-Sep-22 02:18 AM
they all chased women
02:18
not one ever gave me a red pill
02:19
all of them had as JK says mental images of the women they chased
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Cast 21-Sep-22 02:19 AM
I think its mindset
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veganpermanently 21-Sep-22 02:19 AM
all false ofc
02:19
getting heart broken all the time
02:20
so I never approached women, just tried to better my life, tho' didn't have the technique for it
02:20
nonetheless it attracted lots of women
02:21
and still it made me create these mental images they fed consciously or not
02:21
in 2017 found some red pills laying around
02:22
a friend told me to go more in the direction of mgtow
02:22
I hesitated but was curious
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Cast 21-Sep-22 02:22 AM
Mgtow sounds depressing
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veganpermanently 21-Sep-22 02:22 AM
a year later I took my last blue pill and washed it down with a fist full of red ones
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Cast
Mgtow sounds depressing
veganpermanently 21-Sep-22 02:23 AM
quite the contrary
02:23
it's peaceful
02:23
inspiring
02:24
the problem is that Hollywood really washed people's minds over time
02:24
everyone thinks every hero needs a princess to save
02:25
in reality most heroes save themselves from almost certain death
02:25
in rare situations they save strangers regardless of gender and it doesn't lead to a relationship
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ibtisam.midlet 21-Sep-22 03:29 AM
@erin reach me in DMs
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veganpermanently 21-Sep-22 04:08 AM
My full stack /tested fully/: Mood stabilization, cognition: 100 mg CDP Choline q3D AM 100 mg Ginkgo biloba std. 24% 50 mg 7, 8 DHF subL qAM 30 mg Modafinil qAM 20 mg PQQ qAM 1 mg Memantine q3D AM Self-work: 200 mg Psilocin q6month 200 mg d9THC qmonth 50 mg Memantine qmonth Longevity: 1900 mg MSM qAM 100 mg D-Glucosamine qAM 5 mg Rapamycin qw
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veganpermanently
My full stack /tested fully/: Mood stabilization, cognition: 100 mg CDP Choline q3D AM 100 mg Ginkgo biloba std. 24% 50 mg 7, 8 DHF subL qAM 30 mg Modafinil qAM 20 mg PQQ qAM 1 mg Memantine q3D AM Self-work: 200 mg Psilocin q6month 200 mg d9THC qmonth 50 mg Memantine qmonth Longevity: 1900 mg MSM qAM 100 mg D-Glucosamine qAM 5 mg Rapamycin qw
ibtisam.midlet 21-Sep-22 04:57 AM
does pqq potent
04:58
also DHF
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ibtisam.midlet
does pqq potent
veganpermanently 21-Sep-22 04:58 AM
with this stack it enhances it significantly
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ibtisam.midlet
also DHF
veganpermanently 21-Sep-22 04:59 AM
provides mental clarity acutely
04:59
for a few hours
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ibtisam.midlet 21-Sep-22 04:59 AM
how you get d9THC exctly
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ibtisam.midlet
how you get d9THC exctly
veganpermanently 21-Sep-22 04:59 AM
nice try FBI
🤣 1
05:00
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ibtisam.midlet 21-Sep-22 05:03 AM
not today CIA emoji_49
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Yana
https://archive.org/details/serial-experiments-lain-episode-1
ibtisam.midlet 21-Sep-22 05:34 AM
was you watching it in ur childhood?
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ibtisam.midlet 21-Sep-22 07:47 AM
Image attachment
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MEE6 BOT 21-Sep-22 07:47 AM
@ibtisam.midlet, you have advanced to lvl 19 respect++ emoji_51
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veganpermanently
My full stack /tested fully/: Mood stabilization, cognition: 100 mg CDP Choline q3D AM 100 mg Ginkgo biloba std. 24% 50 mg 7, 8 DHF subL qAM 30 mg Modafinil qAM 20 mg PQQ qAM 1 mg Memantine q3D AM Self-work: 200 mg Psilocin q6month 200 mg d9THC qmonth 50 mg Memantine qmonth Longevity: 1900 mg MSM qAM 100 mg D-Glucosamine qAM 5 mg Rapamycin qw
erin 21-Sep-22 07:48 AM
Embedded image
07:50
oh thats sposed to say 2mg naltrexone BID not 4mg
07:50
4mg total
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Yana
https://archive.org/details/serial-experiments-lain-episode-1
erin 21-Sep-22 07:58 AM
required watching
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ibtisam.midlet
Someone sent me MTF Bible
erin 21-Sep-22 07:59 AM
thats a good one
07:59
have you seen https://transfemscience.org/
Transfeminine Science
Transfeminine Science is a site for information on hormone therapy for transfeminine people.
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08:00
its written by the girl who also authored like 85% of all the wikipedia articles on the majority of transfem-related shit
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erin
required watching
Yana 21-Sep-22 08:11 AM
Is SEL secretly an allegory for transitioning
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erin
its written by the girl who also authored like 85% of all the wikipedia articles on the majority of transfem-related shit
Netizenne 21-Sep-22 08:25 AM
sad amount of mentally ill people in their discord
08:25
not much science going on in it
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erin 21-Sep-22 08:26 AM
absolutely
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Netizenne 21-Sep-22 08:27 AM
I tried talking about science there and someone straight up admitted there was no point trying and that it was more of a daycare for the mentally ill than anything else at that point :/ (edited)
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erin 21-Sep-22 08:27 AM
wait they have a discord separate from TransDIY?
08:28
cause that one is p stinky
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erin
wait they have a discord separate from TransDIY?
Netizenne 21-Sep-22 08:28 AM
Idk
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erin 21-Sep-22 08:28 AM
theres a hidden neurochem channel that is 95% drug addicts
08:28
super disappointing
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erin
theres a hidden neurochem channel that is 95% drug addicts
Netizenne 21-Sep-22 08:28 AM
Ya I was in there lol
08:29
I tried talking about semax releasing BDNF and they got all evangelical about how dangerous it was being a armchair biologist before going back to talking about mdma despair
08:30
It was absolutely ridiculous
08:30
That person had a split personality and thought they were an alien and viewed everyone else as subhuman, also extremely neurotic, narcissistic, and hard to be around (edited)
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veganpermanently
try approach men no homo
Netizenne 21-Sep-22 08:32 AM
I can’t do either
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Mabus Tiefsee 21-Sep-22 08:41 AM
@ibtisam.midlet a since you are biohacking for beauty, may i recomend this exercise https://youtu.be/14veOCV46z8 in males muscle training without that causes bubble gut. If you train anything it won't be as bad in females, however i saw slim fit women with a belly because of this.
Fraser Wilson
How To Stomach Vacuum | 2021
💟 1
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Mabus Tiefsee
@ibtisam.midlet a since you are biohacking for beauty, may i recomend this exercise https://youtu.be/14veOCV46z8 in males muscle training without that causes bubble gut. If you train anything it won't be as bad in females, however i saw slim fit women with a belly because of this.
blank 21-Sep-22 08:52 AM
this is pretty much the only exercise along chin ups that I've consistently done throughout my life and even though my lifestyle is like shit I somehow manage to maintain decent frame
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Mabus Tiefsee 21-Sep-22 08:54 AM
for a slimer V waist, also train the side muscles. Simply moving your hips in an other direction than your torso during walking. Sideeffect, you will create a chad walk
08:55
08:58
@Netizenne i can give you a great advice for getting women my brother gave me "just be around them" and during careval when everybody wears masks "just show them your face" worked like a charm for him however never worked for me, he produced way more IGF1 during development and that showed in his height and face
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Cast 21-Sep-22 08:58 AM
Lmao
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Mabus Tiefsee 21-Sep-22 08:59 AM
"Where did you learn your muscle training?" "Old wacky russian cartoons"
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Cast 21-Sep-22 09:01 AM
My IQ is definetly high rn
09:02
Overrall the function of my hippocampus has improved drastically due to what I think is ha p6
09:02
My PFC has also been developing well
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Cast
Mgtow sounds depressing
Mabus Tiefsee 21-Sep-22 09:03 AM
it depend on your life goals, if ypur life goals have anything with a woman long therm in mind, yes if not, it will give you freedom.
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Mabus Tiefsee
it depend on your life goals, if ypur life goals have anything with a woman long therm in mind, yes if not, it will give you freedom.
Cast 21-Sep-22 09:03 AM
Not for me then
09:03
I need a babe to keep me company when im rich (edited)
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Mabus Tiefsee
@Netizenne i can give you a great advice for getting women my brother gave me "just be around them" and during careval when everybody wears masks "just show them your face" worked like a charm for him however never worked for me, he produced way more IGF1 during development and that showed in his height and face
Netizenne 21-Sep-22 09:03 AM
How do I get around them??
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Cast
Overrall the function of my hippocampus has improved drastically due to what I think is ha p6
Mabus Tiefsee 21-Sep-22 09:04 AM
i fear i have to do something, i guess the "brain fog" of corona got me 🤯
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Cast 21-Sep-22 09:04 AM
What are you taking?
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Netizenne
How do I get around them??
Mabus Tiefsee 21-Sep-22 09:04 AM
just go to them, be good lucking and tall - the rest will just work
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Cast
What are you taking?
Mabus Tiefsee 21-Sep-22 09:05 AM
so far nothing for the brain (just B3 as nadh+ booster and s natural igf1 sourcr from time to time)
09:05
@Netizenne what is your age?
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Cast 21-Sep-22 09:05 AM
You should take dha
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Netizenne 21-Sep-22 09:05 AM
21
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Cast 21-Sep-22 09:06 AM
Ive been taking it for a bit over a month its beneficial as hell
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Netizenne
21
Mabus Tiefsee 21-Sep-22 09:06 AM
yeah might be to late for size increase, but we can still grow your chin, cheekbones, nose, muscles and dick
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Cast
Ive been taking it for a bit over a month its beneficial as hell
Mabus Tiefsee 21-Sep-22 09:07 AM
can you write me a PM where to get it and the full name?
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Mabus Tiefsee
so far nothing for the brain (just B3 as nadh+ booster and s natural igf1 sourcr from time to time)
Netizenne 21-Sep-22 09:07 AM
Are there ways to get the mental benefits of igf1 without letting it change bone structures, facial features, cartilage and stuff? Is that even a concern at 21?
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Mabus Tiefsee 21-Sep-22 09:07 AM
i fear i loose the ibfos otherwise in the chat
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Mabus Tiefsee
yeah might be to late for size increase, but we can still grow your chin, cheekbones, nose, muscles and dick
Netizenne 21-Sep-22 09:07 AM
I don’t want!!!
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Mabus Tiefsee
can you write me a PM where to get it and the full name?
Cast 21-Sep-22 09:07 AM
Its not not some state of the art nootropic its just fish oil. You can get it anywhere
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Netizenne 21-Sep-22 09:08 AM
DHA is an omega 3 fatty acid The other main one you’ll hear about is EPA
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Netizenne
Are there ways to get the mental benefits of igf1 without letting it change bone structures, facial features, cartilage and stuff? Is that even a concern at 21?
Mabus Tiefsee 21-Sep-22 09:09 AM
all mental alterations of igf1 qre indirectly caused because if the body alterations it causes. For a full list of all side effects, read abour Agromegaly and Gigantism. From my experience, the worst part is the tiredness wenn your muscle grow, i hate that!
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Cast
Its not not some state of the art nootropic its just fish oil. You can get it anywhere
Mabus Tiefsee 21-Sep-22 09:09 AM
perfect! And since i lost my taste, i can just chug it!
09:10
slowly i feel like a stoneage biohacker, collecting berrys for resvertorol, eating liver for igf1, soon fish oil.... yeah.....
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Netizenne 21-Sep-22 09:10 AM
I want to either snort it if doesn’t cross bbb and go peripheral. Or maybe just inhibit one of its binding proteins (IGFBPs) that are selectively localized in the brain -if such exists. (edited)
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Mabus Tiefsee
perfect! And since i lost my taste, i can just chug it!
Cast 21-Sep-22 09:11 AM
No its capsules
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Netizenne
I want to either snort it if doesn’t cross bbb and go peripheral. Or maybe just inhibit one of its binding proteins (IGFBPs) that are selectively localized in the brain -if such exists. (edited)
Mabus Tiefsee 21-Sep-22 09:12 AM
there is an easy way to get stuff in your body all over the place. That's how i get my igf1 oraly out if liver. just increase the amount, something will go everywhere! Also add fat in case it is fat solvable. Eat fat and a lot of that stuff
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Netizenne 21-Sep-22 09:13 AM
It looks like IGFBP2 is fairly specific to the brain. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883226/ There’s like 7 different types and basically what they do is bind to insulin or igf and keep them from being active. (edited)
IGFBP-2 Signaling in the Brain: From Brain Development to Higher Or...
Insulin-like growth factor-binding protein-2 (IGFBP-2) is a pleiotropic polypeptide that functions as autocrine and/or paracrine growth factors. IGFBP-2 is the most abundant of the IGFBPs in the cerebrospinal fluid (CSF), and developing brain showed the ...
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Cast
No its capsules
Mabus Tiefsee 21-Sep-22 09:13 AM
i tought more oldshool like cod liver oil
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Netizenne 21-Sep-22 09:17 AM
In this one metanalysis of SNPs associated with high iq -the mutations most associated with extremely high iq were in the genes for the enzymes that “cleave” IGFBP3 and 5. https://www.nature.com/articles/mp2017121 (edited)
09:17
https://pubmed.ncbi.nlm.nih.gov/11095942/
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Netizenne
It looks like IGFBP2 is fairly specific to the brain. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883226/ There’s like 7 different types and basically what they do is bind to insulin or igf and keep them from being active. (edited)
Mabus Tiefsee 21-Sep-22 09:18 AM
okay, i have to alter my statement from above, igf1 does seem to alter stuff in the brain. It is likely it activates the same pathways. Just not as often/good. Also read about insulin if it crosses the blood brain barrier. It is litteraly in the name it is insulin like. Therefore we can just assume the insulin data sheet. never freeze it or heat it above 40°C
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Netizenne
In this one metanalysis of SNPs associated with high iq -the mutations most associated with extremely high iq were in the genes for the enzymes that “cleave” IGFBP3 and 5. https://www.nature.com/articles/mp2017121 (edited)
Netizenne 21-Sep-22 09:19 AM
Although I don’t really know what they mean by cleave and wish they clarified that a bit more. Does ADAM12 cleaving IGFBP3 mean that it breaks it down? Does it mean that it separates it from IGF -freeing the IGF? Does it break down both IGF and IGFBP??? I wish I knew
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Netizenne
Are there ways to get the mental benefits of igf1 without letting it change bone structures, facial features, cartilage and stuff? Is that even a concern at 21?
Mabus Tiefsee 21-Sep-22 09:21 AM
facial structure and bone density will change, as long as you got enough calcium. muscles only grow when you train. And dick will only grow if you watch a porn marathon
09:22
however most males benefit from the facial changes. Most females, the look faster older/like a guy
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Mabus Tiefsee
okay, i have to alter my statement from above, igf1 does seem to alter stuff in the brain. It is likely it activates the same pathways. Just not as often/good. Also read about insulin if it crosses the blood brain barrier. It is litteraly in the name it is insulin like. Therefore we can just assume the insulin data sheet. never freeze it or heat it above 40°C
Netizenne 21-Sep-22 09:23 AM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665562/#!po=13.0000 This other study on genes associated with iq also found a few related to insulin
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Genome-wide association meta-analysis of 78,308 individuals identif...
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Netizenne
Although I don’t really know what they mean by cleave and wish they clarified that a bit more. Does ADAM12 cleaving IGFBP3 mean that it breaks it down? Does it mean that it separates it from IGF -freeing the IGF? Does it break down both IGF and IGFBP??? I wish I knew
Netizenne 21-Sep-22 09:25 AM
@Pax1l you know about this? Maybe the whole conversation starting from the top would interest you (edited)
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Netizenne
I tried talking about semax releasing BDNF and they got all evangelical about how dangerous it was being a armchair biologist before going back to talking about mdma despair
veganpermanently 21-Sep-22 09:29 AM
that's like every druggie out there
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Mabus Tiefsee 21-Sep-22 09:30 AM
@Netizenne long story short, is high insulin or IGF1 good or bad for the memmory? (edited)
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Netizenne
@Pax1l you know about this? Maybe the whole conversation starting from the top would interest you (edited)
veganpermanently 21-Sep-22 09:30 AM
no it means it releases it
09:30
i.e. cleaves it from the proIGF peptide or whatever (edited)
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Mabus Tiefsee 21-Sep-22 09:46 AM
@ibtisam.midlet also since you seem to be a female, you might alter the walking in a more feminine way and yes, the best example video i could find is again a meme... sorry but their walking is just spot on and feminine https://youtu.be/gy0h0g6szNg
Angry Crimson
jojo's chad walking adventure (phonky town edition)
09:48
and if you sligtly go down in the knees, you will use your gluteus maximus more and therefore get a nice ass. Just by walking
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veganpermanently
i.e. cleaves it from the proIGF peptide or whatever (edited)
Netizenne 21-Sep-22 10:04 AM
Ohhhhhh That makes more sense. So inhibiting adam12 would lower the reproduction of free igfbp3/5 then? The mutations associated with high is found on the adam12 gene probably inhibit it’s function then (also most novel mutations tend to decrease function rather than improve). (edited)
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Netizenne
Ohhhhhh That makes more sense. So inhibiting adam12 would lower the reproduction of free igfbp3/5 then? The mutations associated with high is found on the adam12 gene probably inhibit it’s function then (also most novel mutations tend to decrease function rather than improve). (edited)
veganpermanently 21-Sep-22 10:05 AM
yeah
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Mabus Tiefsee 21-Sep-22 10:10 AM
@Netizenne ah can you send me a picture of your face via PM. Then i can say how bad the igf1 (or similar substances) could be in the worst case. Also the strenght of your fingernails tells us your igf1 leveles. Thick strong fingernails mean a lot igf1, weak thin mean less igf1
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Netizenne
In this one metanalysis of SNPs associated with high iq -the mutations most associated with extremely high iq were in the genes for the enzymes that “cleave” IGFBP3 and 5. https://www.nature.com/articles/mp2017121 (edited)
Netizenne 21-Sep-22 10:11 AM
https://www.proteinatlas.org/ENSG00000115461-IGFBP5/tissue IGFBP5 isn’t found in the brain much (looks like it’s more associated with breasts) so it must be IGFBP3 that’s the reason why ADAM12s associated with iq (that is -if it’s even adam12s effect on IGF that’s the relevant detail associating it to I since it does a few other things too). (edited)
Tissue expression of IGFBP5 - Summary - The Human Protein Atlas
Summary of IGFBP5 expression in human tissue.
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Mabus Tiefsee 21-Sep-22 10:12 AM
and just vitamin D and Zink increase your natural background igf1. Found that out when a female friend took that for stronger fingernails. Her stronger chin she gained in that time made her look older and manlier, luckily shes lesbian therefore it is a benefit....
10:15
https://www.ncbi.nlm.nih.gov/gene/3488
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10:19
@Netizenne eat raw ovarys (might contain other feminibe hormons you don't want) or raw kidneys it is not human exclusive i hope??? otherwise go for children, less disease risks, less prions.
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Mabus Tiefsee
and just vitamin D and Zink increase your natural background igf1. Found that out when a female friend took that for stronger fingernails. Her stronger chin she gained in that time made her look older and manlier, luckily shes lesbian therefore it is a benefit....
Netizenne 21-Sep-22 10:38 AM
Ya is really rather not look manly, optimally we’d find a way to keep it to the brain
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Mabus Tiefsee 21-Sep-22 10:46 AM
yeah in that case: don't eat raw meat from young animals don't increase IGF1 itself, just try the others high vitamin D low vitamin K during that week no calcium rich food during that week (your bones can't grow without calcium)
10:46
@Netizenne wait, you are female?
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Netizenne
Ya is really rather not look manly, optimally we’d find a way to keep it to the brain
Mabus Tiefsee 21-Sep-22 10:49 AM
oh and from my experience, increasing the bloodflow to an areay increases the igf1 effects in that area. I assume it is the same for IGFBP5. Therefore do stuff that makes you think a lot. (Those things you want to improve anyway would be the best choice)
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Cast 21-Sep-22 10:53 AM
Lol the guy at the desk for my gym looks like johnny sins
10:57
@veganpermanently yea i didnt find her but atleast that gives me time to start taking my supps
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veganpermanently 21-Sep-22 11:03 AM
ya'll creepy
11:03
if I was female I would RUN
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veganpermanently
ya'll creepy
Cast 21-Sep-22 11:26 AM
Whats with u all the sudden
11:26
Sounding like llama
11:28
I dont wanna go around looking for her i think ill just add her on insta
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Mabus Tiefsee
oh and from my experience, increasing the bloodflow to an areay increases the igf1 effects in that area. I assume it is the same for IGFBP5. Therefore do stuff that makes you think a lot. (Those things you want to improve anyway would be the best choice)
Netizenne 21-Sep-22 11:42 AM
PDE1c was also associated with iq if you look at those charts ibti put together. A drug that antagonizes it is known for increasing cerebral blood flow. I’ve been thinking about bloodflow a fair bit too. (edited)
Eyespop 1
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Netizenne
PDE1c was also associated with iq if you look at those charts ibti put together. A drug that antagonizes it is known for increasing cerebral blood flow. I’ve been thinking about bloodflow a fair bit too. (edited)
veganpermanently 21-Sep-22 11:43 AM
trepanation nation
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Netizenne
Although I don’t really know what they mean by cleave and wish they clarified that a bit more. Does ADAM12 cleaving IGFBP3 mean that it breaks it down? Does it mean that it separates it from IGF -freeing the IGF? Does it break down both IGF and IGFBP??? I wish I knew
Pax1l 21-Sep-22 11:45 AM
Yes
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Cast 21-Sep-22 11:45 AM
Alr i added her
11:45
When she adds me back im dm
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Netizenne
That person had a split personality and thought they were an alien and viewed everyone else as subhuman, also extremely neurotic, narcissistic, and hard to be around (edited)
Pax1l 21-Sep-22 11:59 AM
Its good to remind ourselves that isnt really too uncommon especially in our space which revolves around cognitive enhancing drugs
12:01
Im currently trying to pick apart my own insecurities and its really easy to get comfortable behind the image that you want to present yourself as to others
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Netizenne
PDE1c was also associated with iq if you look at those charts ibti put together. A drug that antagonizes it is known for increasing cerebral blood flow. I’ve been thinking about bloodflow a fair bit too. (edited)
Netizenne 21-Sep-22 12:02 PM
Some more information on blood thinners (like piracetam or ginggko which reduce platelet count):
it has been suggested that blood viscosity is an important independent regulator of cerebral blood flow (CBF). In rigid tubes, flow and viscosity are inversely related. If the cerebral circulation behaves as a rigid tube, and if perfusion pressure remains constant, CBF should increase as blood viscosity is reduced.
https://journals.physiology.org/doi/full/10.1152/ajpheart.2000.279.4.H1949 (edited)
12:02
Blood viscosity is an important determinant of blood flow—the higher the viscosity, the lower the blood flow–and this is significantly linked with cognitive function.
https://holisticprimarycare.net/topics/healthy-aging/blood-viscosity-the-role-of-blood-flow-in-cognitive-function/
Blood Viscosity: The Role of Blood Flow in Cognitive Function - Hol...
High blood viscosity, a robust predictor of cardiovascular disease risk, is also predictive of cognitive dysfunction in older people, and may be an early indicator of the risk of Alzheimer's disease.
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Pax1l 21-Sep-22 12:04 PM
If you want to improve igf1 sensitivity or increase its activity within the brain then beta secretase inhibition, ptp1b inhibition or intranasal use of insulin/mgf/igf2 would be a good option
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Netizenne 21-Sep-22 12:04 PM
(Kinda off topic/ slightly unrelated theory I had on sphingolipids, platelets, and blood flow) Sphingolipids are used for making cell membranes and you need lots for necessary functions such as dentritogenesis and moving receptors around the surface of the cell. Here’s the theory: When blood is thin (low platelets) cerebral blood flow is improved and the brains capacity to use energy is raised if needed. Maybe sphingolipids are an intermediary signal to the brain that it has the resources/conditions to grow (and expend energy) -both in terms of membrane building materials and in terms of blood supply. But I haven’t seen studies saying this explicitly unfortunately so it’s just a guess, and a bit of a crude one at that imo as I really don’t feel I’ve read as much as on the topic as I could have (edited)
12:04
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Netizenne
PDE1c was also associated with iq if you look at those charts ibti put together. A drug that antagonizes it is known for increasing cerebral blood flow. I’ve been thinking about bloodflow a fair bit too. (edited)
Mabus Tiefsee 21-Sep-22 12:04 PM
yeah someone gave me ginko balboa extract, all side effects let it seem like it just increases bloodflow and that in returm brain function
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Netizenne
Some more information on blood thinners (like piracetam or ginggko which reduce platelet count):
it has been suggested that blood viscosity is an important independent regulator of cerebral blood flow (CBF). In rigid tubes, flow and viscosity are inversely related. If the cerebral circulation behaves as a rigid tube, and if perfusion pressure remains constant, CBF should increase as blood viscosity is reduced.
https://journals.physiology.org/doi/full/10.1152/ajpheart.2000.279.4.H1949 (edited)
Mabus Tiefsee 21-Sep-22 12:05 PM
i should read everything before commenting, should
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veganpermanently 21-Sep-22 12:06 PM
I think high dosing ginkgo was a bad idea
12:07
I had lots of fast heart beats out of nowhere past few days, chest pains, hearing heartbeat at the back of my neck
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Pax1l 21-Sep-22 12:07 PM
Some of the biggest determining factors on blood viscosity is consumption of high saturated fat meals, high white blood cell counts, dietary cholesterol, increased expression kf clotting factors such as very fast death factor 5
Peeponotes 1
Prayge 1
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Pax1l
Some of the biggest determining factors on blood viscosity is consumption of high saturated fat meals, high white blood cell counts, dietary cholesterol, increased expression kf clotting factors such as very fast death factor 5
veganpermanently 21-Sep-22 12:07 PM
sludge bloood
12:08
go vegan mofo
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Pax1l
Some of the biggest determining factors on blood viscosity is consumption of high saturated fat meals, high white blood cell counts, dietary cholesterol, increased expression kf clotting factors such as very fast death factor 5
Netizenne 21-Sep-22 12:08 PM
My anatomy class is gonna cover the cardiovascular system this semester!!! Very excited
😳 1
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Mabus Tiefsee 21-Sep-22 12:08 PM
carnivore diet all the way! remove carbs
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veganpermanently 21-Sep-22 12:09 PM
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Pax1l 21-Sep-22 12:09 PM
Ive been doing a cursory search on laminin derived peptides and the extracellular matrix
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veganpermanently 21-Sep-22 12:09 PM
apex predator lurking
12:09
@Netizenne what's the pde1c drug
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Pax1l 21-Sep-22 12:10 PM
Really compelling data surrounding self assembling peptides such as rada16 conjugated to peptides such as yigsr.
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Mabus Tiefsee 21-Sep-22 12:10 PM
the main problem with meat based diets, you can't get good meat anymore. My dad worked once with the stuff they give the animals for making their meat gather more water.....
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Pax1l 21-Sep-22 12:11 PM
Dont they inject phosphates into meats like chicken to do that anyways
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veganpermanently
@Netizenne what's the pde1c drug
Netizenne 21-Sep-22 12:13 PM
Vinpocetine
12:13
!!
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Netizenne
Vinpocetine
veganpermanently 21-Sep-22 12:13 PM
noooooooooooooooooo
despair 1
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Netizenne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665562/#!po=13.0000 This other study on genes associated with iq also found a few related to insulin
Netizenne 21-Sep-22 12:13 PM
@veganpermanently check these charts
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veganpermanently 21-Sep-22 12:13 PM
VMAT2 inhibitor dutty
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veganpermanently
noooooooooooooooooo
Netizenne 21-Sep-22 12:13 PM
Ikr despair
12:14
For vmat context: https://www.longecity.org/forum/topic/23457-vinpocetine-ditch-it/ (edited)
Vinpocetine -- Ditch It - Brain Health
Page 1 of 4 - Vinpocetine -- Ditch It - posted in Brain Health: I have come to the conclusion that vinpocetine should be eradicated from our supplement stashes. This is due in light of evidence brought about by "dopamine" who is now posting more frequently on our boards.This is taken from M & M, a thread started by dopamine.Vinpocetine (ethyl a...
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Pax1l 21-Sep-22 12:14 PM
Wish you took some time to look more into deferoxamine netizenne
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veganpermanently 21-Sep-22 12:14 PM
most vinca minor alkaloids are poisonous
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Netizenne
For vmat context: https://www.longecity.org/forum/topic/23457-vinpocetine-ditch-it/ (edited)
Netizenne 21-Sep-22 12:15 PM
Have you given this a good look vegan? I think people start to defend it on the second page. I don’t have the time rn or when I’d first found it
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Pax1l 21-Sep-22 12:15 PM
It seems that some of the effects of dfo increasing stem cell differntiation from hif1a are dependant on increasing pge1 expression
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Netizenne
Have you given this a good look vegan? I think people start to defend it on the second page. I don’t have the time rn or when I’d first found it
veganpermanently 21-Sep-22 12:15 PM
I did they're retarded
12:15
Longecity as usual
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Pax1l
Wish you took some time to look more into deferoxamine netizenne
Netizenne 21-Sep-22 12:15 PM
I should when we’re covering the cardiovascular system in class!!!
12:16
Atm it’s been hard to get into
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Pax1l
It seems that some of the effects of dfo increasing stem cell differntiation from hif1a are dependant on increasing pge1 expression
veganpermanently 21-Sep-22 12:16 PM
prostaglandin?
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veganpermanently
prostaglandin?
Pax1l 21-Sep-22 12:17 PM
Yes
12:18
Borneol is an interesting compound worth looking at as well especially regarding increasinf vegf expression. It is also a novel penetration enhancer and glycoprotein inhibitor so i think itd be quite synergistic intranasally with berberine or curcumin
emoji_52 1
12:19
I think i will splurge on a vacuum blender so I can make dha curcumin microemulsions
emoji_51 1
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Pax1l
Borneol is an interesting compound worth looking at as well especially regarding increasinf vegf expression. It is also a novel penetration enhancer and glycoprotein inhibitor so i think itd be quite synergistic intranasally with berberine or curcumin
veganpermanently 21-Sep-22 12:20 PM
came across the penetration enhancing use case before didn't know abotu vegf
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Pax1l 21-Sep-22 12:23 PM
Yeah there was a fairly nice study looking at its coadministration with geniposide
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Pax1l
Yeah there was a fairly nice study looking at its coadministration with geniposide
veganpermanently 21-Sep-22 12:37 PM
https://www.youtube.com/watch?v=KsK_bBiFfUY
Kidology
It's deeper than you think
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Netizenne
My anatomy class is gonna cover the cardiovascular system this semester!!! Very excited
JK 21-Sep-22 12:38 PM
What are u studying?
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veganpermanently 21-Sep-22 12:52 PM
https://www.youtube.com/watch?v=ibKGjfXBmE4
TBH
The man who killed Andrew Tate & Filthy Frank
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Pax1l
Yeah there was a fairly nice study looking at its coadministration with geniposide
veganpermanently 21-Sep-22 01:07 PM
https://incatrailterpenes.com/products/borneol berry nice
All Natural Botanically Derived Fragrance - Borneol Terpene Isolate
Find great deals on Borneol and other botanical all-natural terpenes at Inca Trail Terpenes. Visit now for high-quality, lab tested terpenes at unbelievable prices. We have a vast selection of lab tested, all-natural terpenes so you can shop with confidence.
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JK
What are u studying?
Netizenne 21-Sep-22 01:10 PM
The sciences of biology and such (edited)
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JK 21-Sep-22 01:21 PM
Awesome! Im considering going back to studying, biochemistry in mind
13:22
Maybe part time
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veganpermanently 21-Sep-22 01:22 PM
me too
13:22
I went to a campus today
13:22
all of the little girls were looking at me
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JK 21-Sep-22 01:22 PM
..
13:22
Because u look like Marcus Aurelius (edited)
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veganpermanently 21-Sep-22 01:22 PM
emoji_49
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JK 21-Sep-22 01:23 PM
What will u study man? (edited)
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veganpermanently 21-Sep-22 01:23 PM
pussy science
13:23
I'm gonna be a vagina MD
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JK 21-Sep-22 01:23 PM
seems like you’ve already got that under control
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veganpermanently 21-Sep-22 01:24 PM
jk
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JK 21-Sep-22 01:24 PM
No really
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veganpermanently 21-Sep-22 01:24 PM
everything I say has so many meanings bro
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JK 21-Sep-22 01:24 PM
Gynecologist is a well established field of science
13:24
Just do your thing bro
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veganpermanently 21-Sep-22 01:25 PM
I wanted to express how studying at a university would be an unnecessary distraction
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JK 21-Sep-22 01:25 PM
That’s why I’m considering doing it online
13:25
Lab days not included (edited)
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veganpermanently 21-Sep-22 01:26 PM
noice
13:26
I'd do that as well
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JK 21-Sep-22 01:27 PM
if I go, I will fall right back into trying to be the chaddest in the class, probably skip a few to talk to girls etc
13:27
And then waste 3 years again
13:28
So might as well establish a routine around work and carrier and use it as a tool
13:28
Do it from home
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veganpermanently 21-Sep-22 01:29 PM
I'm so vulnerable to pretty women and cool friends
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JK 21-Sep-22 01:32 PM
Yeah me too. It’s a trauma from early days, not feeling included I think. Usually I don’t give a rats ass about who likes me. I consider my own morals, viewpoints and such first, and closest friends second. But as soon as my anima starts showing interest in me, I get in this weird state, where I ask myself. Should I deliberately fall in love with this image and enjoy the unplanned mysticism of life, or should I say fuck it, I’ve got other stuff to do… And miss out on insane sex
13:32
Lifes hard like that..
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veganpermanently 21-Sep-22 01:34 PM
Same
13:34
but the older I am the more I choose the purpose
13:34
so I'm feeling optimistic
13:40
@Netizenne u said horns I want annunaki head
Image attachment
13:44
Image attachment
13:45
man has a helmet to protecc his exposed brain
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Yana
Is SEL secretly an allegory for transitioning
erin 21-Sep-22 01:50 PM
no theres just a lot of high IQ, terminally online, schizo trans girls. so it fits into the canon
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erin
no theres just a lot of high IQ, terminally online, schizo trans girls. so it fits into the canon
veganpermanently 21-Sep-22 01:51 PM
i miss emi
despair 1
13:51
975870265147940914
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veganpermanently
i miss emi
Netizenne 21-Sep-22 02:06 PM
Fr why
14:06
Some say Yana is an Emi alt looooool
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Netizenne
Some say Yana is an Emi alt looooool
veganpermanently 21-Sep-22 02:06 PM
nah
14:07
emi is gone
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Netizenne 21-Sep-22 02:07 PM
sirsad was really paranoid about it for a while lol
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veganpermanently 21-Sep-22 02:07 PM
maybe dead
Heartsunken 1
14:07
and maybe
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Netizenne 21-Sep-22 02:07 PM
they had a bf in Sweden or something right? maybe she is living happily ever after there on govt money….. (edited)
emoji_50 1
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veganpermanently 21-Sep-22 02:07 PM
gettin split by her bodybuilder boyfriend
14:11
https://www.youtube.com/watch?v=MJxbiHBpSc4
Teal Swan
Containment - What a Woman Needs From a Man in a Relationship
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veganpermanently
maybe dead
Pax1l 21-Sep-22 02:38 PM
Emi was sub 100lbs and had a 48-24 wake sleep cycle
14:39
Likely no doubt theyre dead
14:41
I have seen emi and they were on the path of a quick demise
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veganpermanently
https://incatrailterpenes.com/products/borneol berry nice
Pax1l 21-Sep-22 02:42 PM
Ive seen crystaline borneol on ebay. Just dont let the mail carriers see it 🤣
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Cast 21-Sep-22 03:28 PM
Damn im autistic as shit arent I
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Cast
Damn im autistic as shit arent I
Pax1l 21-Sep-22 03:39 PM
What brought many of us to the pursuit of cognitive enhancement and medicine is the fact that so many of us are dysfunctional people and relate very little to family or people we often meet
👍 1
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Pax1l
What brought many of us to the pursuit of cognitive enhancement and medicine is the fact that so many of us are dysfunctional people and relate very little to family or people we often meet
Cast 21-Sep-22 03:39 PM
Fax
15:40
Fuckin brutal tho
15:40
I hope its just adhd and not autism
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Pax1l 21-Sep-22 03:41 PM
No. You have an issue with your self image
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Cast 21-Sep-22 03:41 PM
I got alot of issues lol
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Pax1l 21-Sep-22 03:42 PM
If i can allow myself to be honest with myself maybe i can become disciplined and address my personal issues
15:44
Youre not going to find much advice in our circles telling you how to fix procrastination or fix anxiety that is buried within
15:47
Traumas throughout life have seeded a lot of issues with myself that Im going to fix but it is painful.
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Cast 21-Sep-22 03:48 PM
Ima just take ashwaganda
😆 1
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Pax1l 21-Sep-22 03:48 PM
What do you want out of a community like this?
15:50
If we ask ourselves this more often I think we might see ways the community can change because we address our personal issues
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veganpermanently
I had lots of fast heart beats out of nowhere past few days, chest pains, hearing heartbeat at the back of my neck
𝔘𝔵𝔨ü𝔩𝔩 21-Sep-22 03:58 PM
yep I had that too when I accidentally doubled my dose, no benefits past 100mg ime just more side effects.
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Mabus Tiefsee
carnivore diet all the way! remove carbs
𝔘𝔵𝔨ü𝔩𝔩 21-Sep-22 03:59 PM
carnivore is not sustainable long-term, body needs carbs for proper thyroid and kidney function, cycling carnivore/keto can be beneficial though.
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Cast 21-Sep-22 04:19 PM
My Iq has gone up significantly
16:19
I dont take notes in school i just memorize it all
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Cast
I got alot of issues lol
Netizenne 21-Sep-22 04:55 PM
Same!!!!!! Awwwhhh
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Sn0wFly 21-Sep-22 05:13 PM
Hi! Does anyone here have experience with Modafinil? I have a few questions and I'm not finding answers on google 😨
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Sn0wFly
Hi! Does anyone here have experience with Modafinil? I have a few questions and I'm not finding answers on google 😨
macross89 21-Sep-22 05:45 PM
me
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macross89
me
Sn0wFly 21-Sep-22 05:46 PM
Can i ask you? In theory tomorrow I should take the first dose but I'm a little scared
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Mabus Tiefsee
yeah might be to late for size increase, but we can still grow your chin, cheekbones, nose, muscles and dick
Yana 21-Sep-22 06:17 PM
How
18:17
Do not say bone smashing
18:18
Or chinese rat piss HGH
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Netizenne
sirsad was really paranoid about it for a while lol
Yana 21-Sep-22 06:23 PM
Ain't no way he was serious when I have never talked about naughty drugs like antipsychotics or antidepressants
18:27
My stack to emi's is a militia vs a superpower nation's combined arms
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Netizenne
In this one metanalysis of SNPs associated with high iq -the mutations most associated with extremely high iq were in the genes for the enzymes that “cleave” IGFBP3 and 5. https://www.nature.com/articles/mp2017121 (edited)
Yana 21-Sep-22 06:29 PM
https://pubmed.ncbi.nlm.nih.gov/16263982/ (edited)
Association of insulin-like growth factor I and insulin-like growth...
This study provides some preliminary evidence that IGF-I is associated with brain development in childhood. Additional longitudinal research is required to clarify the role of IGF-I in neurodevelopment. Because IGF-I levels are modifiable through diet and other environmental exposures, this may be o …
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Yana
Or chinese rat piss HGH
Pax1l 21-Sep-22 06:35 PM
Embedded image
18:40
https://pubmed.ncbi.nlm.nih.gov/27075964/
Transplantation of Human Urine-Derived Stem Cells Transfected with ...
The aim of this study was to investigate whether intracavernous injection of urine-derived stem cells (USCs) or USCs genetically modified with pigment epithelium-derived factor (PEDF) could protect the erectile function and cavernous structure in a bilateral cavernous nerve injury-induced erectile d …
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emoji_51 1
18:46
Injecting stemcells from your own piss into your penis is peak decadence
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Pax1l
https://pubmed.ncbi.nlm.nih.gov/27075964/
Yana 21-Sep-22 06:48 PM
Might be the most bat shit study title I've ever read lmao (edited)
18:49
It's literally chinese rat piss 💀
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Netizenne
PDE1c was also associated with iq if you look at those charts ibti put together. A drug that antagonizes it is known for increasing cerebral blood flow. I’ve been thinking about bloodflow a fair bit too. (edited)
Yana 21-Sep-22 06:58 PM
https://pubmed.ncbi.nlm.nih.gov/29520040/ BTW this study compiles both of the other ones you posted (78,308 and the 1247 with 170 IQ)
Biological annotation of genetic loci associated with intelligence ...
Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of …
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Cast 21-Sep-22 08:00 PM
Fuckin brutal
20:01
@veganpermanently holy shit bro
20:02
Yo have no fuckin idea what i just went througj
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Cast 21-Sep-22 10:11 PM
https://pastebin.com/JYgW0puZ
Rough dream and psychoanalysis - Pastebin.com
Pastebin.com is the number one paste tool since 2002. Pastebin is a website where you can store text online for a set period of time.
22:11
If anyone cares to read. Tldr Probably going to get therapy
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Pax1l
Ive seen crystaline borneol on ebay. Just dont let the mail carriers see it 🤣
veganpermanently 21-Sep-22 10:36 PM
why tho it's not illegal
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Cast
https://pastebin.com/JYgW0puZ
veganpermanently 21-Sep-22 10:38 PM
that's a nightmare?
22:38
you clearly never had any stressors in your life
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veganpermanently
why tho it's not illegal
veganpermanently 21-Sep-22 10:38 PM
owww now I get it. we don't have meth here so I was confused lol
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veganpermanently
you clearly never had any stressors in your life
Cast 21-Sep-22 10:42 PM
Go ahead read the conclusion i thought u might say that
22:42
You dont understand its not an isolated event its everything in my life leading up that gives it context
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Cast
Go ahead read the conclusion i thought u might say that
veganpermanently 21-Sep-22 10:43 PM
that's something else bro
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veganpermanently
why tho it's not illegal
Pax1l 21-Sep-22 10:43 PM
it literally looks like crystal meth
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veganpermanently
that's something else bro
Cast 21-Sep-22 10:44 PM
My life is the mycelium and this event is mearly a mushroom. Its the result of my faults.
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veganpermanently 21-Sep-22 10:44 PM
@Cast get therapy if u think u need to
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Cast 21-Sep-22 10:44 PM
I will
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veganpermanently 21-Sep-22 10:45 PM
I had a similar mentality when I was your age
22:46
I don't think it's schizoaffective just a result of whole-life brainwashing by Hollywood and society
👍 1
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veganpermanently
I had a similar mentality when I was your age
Cast 21-Sep-22 10:48 PM
I should have known it was coming but
22:48
Deep down i dont feel depressee
22:48
Deep down im optimistic
22:49
Its just weird to me
22:50
Life seems to give me an oppurtunity and give me hope. Only to flush it down the toilet
22:51
Im stoic to this now. Its just happened too many times. I just feel like an observer rather than a victim
22:52
I can see the reality I want in life but its behind glass forever out of reach
22:53
@veganpermanently im not giving up
22:53
Eventually with this girl i might
22:53
But ill never go mgtow
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Cast
But ill never go mgtow
veganpermanently 21-Sep-22 11:01 PM
unlikely to if you keep failing like this
23:04
what I do know tho
23:05
is that every moment not spent productively is a moment wasted
23:05
https://www.youtube.com/watch?v=968XlstIRS4
CEO of Testosterone 🧬
THIS will destroy your potential as a man…
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Sn0wFly
Hi! Does anyone here have experience with Modafinil? I have a few questions and I'm not finding answers on google 😨
veganpermanently 21-Sep-22 11:09 PM
I do
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𝔘𝔵𝔨ü𝔩𝔩
yep I had that too when I accidentally doubled my dose, no benefits past 100mg ime just more side effects.
veganpermanently 21-Sep-22 11:11 PM
I agree, longevity studies also confirm this. It increased longevity in the small dose but had no effect in the large dose, presumably because of these sides
23:11
it took a while to precipitate tho', I was using it for weeks before this happened
23:13
also I added taurine it might have contributed, now tapering it down.
23:19
GABAergics really make my bruxism way worse over time indicative of an inhibitory deficit
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Netizenne 21-Sep-22 11:43 PM
Damn long day
23:43
tired
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Cast 22-Sep-22 12:58 AM
Jesus theres something really wrong with me
00:58
I just had a fuckin wet dream
00:59
Demon possesed makes sense
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Cast
Jesus theres something really wrong with me
veganpermanently 22-Sep-22 01:01 AM
ur a teen shut up
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veganpermanently
ur a teen shut up
Cast 22-Sep-22 01:01 AM
Im 20
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Cast
Im 20
veganpermanently 22-Sep-22 01:02 AM
that's one year away from nineTEEN
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Cast 22-Sep-22 01:02 AM
Im honestly so confused
01:03
How i attracted so much negative energy (edited)
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veganpermanently 22-Sep-22 01:03 AM
I told u my guy
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Cast 22-Sep-22 01:03 AM
Im not giving up
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veganpermanently 22-Sep-22 01:03 AM
PFC dysfunctional
🤣 1
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Cast 22-Sep-22 01:03 AM
Even if the devil tries to put me down (edited)
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veganpermanently 22-Sep-22 01:04 AM
low inhibitory control
01:04
do u know how much men she left on red
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Cast 22-Sep-22 01:04 AM
Im going to approach her irl
01:04
And actually be competent
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veganpermanently
low inhibitory control
Cast 22-Sep-22 01:05 AM
These dreams are fucking fierce
01:05
Its the devil
01:05
Trying to get in the way
01:06
I wont stop or submit and ill remain stoic
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ibtisam.midlet 22-Sep-22 01:06 AM
Is she the first love 995525573067677707
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Cast 22-Sep-22 01:06 AM
No i dont love her
01:07
I just like her
01:07
And im not gonna let her slip away so easy
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veganpermanently 22-Sep-22 01:07 AM
pure O
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Cast 22-Sep-22 01:07 AM
Theres loud thunder outside
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ibtisam.midlet 22-Sep-22 01:07 AM
You guys never loved!
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veganpermanently 22-Sep-22 01:07 AM
actually compulsive as well
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Cast 22-Sep-22 01:07 AM
I dont think reality likes this
01:08
Yea im not gonna stop
01:08
At all
01:08
Even if lightning strikes me down
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ibtisam.midlet
You guys never loved!
veganpermanently 22-Sep-22 01:09 AM
love leads to heartbreak chems lead to comedown or not if you're a competent biohacker
01:09
I'm on VMAT2 train again
01:09
feels good
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Cast 22-Sep-22 01:10 AM
I also took 4 fulvic humic acid
01:10
Maybe my t levels were too high
01:10
And its also been awhile since I Jacked off
01:11
Its definetly no coincidence that some kind of evil energy is trying ti fuck this up (edited)
01:12
Entering my mind through dreams
01:12
Trying to make me submit and give up
01:12
But i wont
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veganpermanently 22-Sep-22 01:16 AM
murray
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Cast 22-Sep-22 01:17 AM
https://youtu.be/IkmkNFEB3rE
Gerbert Johnson
Awkward and Socially Anxious Men
01:19
I looked like shit and middle school as was bullied
01:20
And earlier highschool
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Cast 22-Sep-22 01:27 AM
So its not goings to be easy to fix the damage
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veganpermanently 22-Sep-22 01:27 AM
for me it was easy because I fought back always
01:28
got beaten up a few times, mobbed, etc.
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Cast 22-Sep-22 01:28 AM
I never got beaten up but
01:28
It was mostly verbal
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veganpermanently 22-Sep-22 01:28 AM
then ur just a pussy
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veganpermanently
then ur just a pussy
Cast 22-Sep-22 01:29 AM
?
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veganpermanently 22-Sep-22 01:29 AM
sticks and stones
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Cast 22-Sep-22 01:29 AM
U mean if i fought back physcially?
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veganpermanently 22-Sep-22 01:29 AM
words don't do shit
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Cast 22-Sep-22 01:29 AM
I mean they kind do
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veganpermanently 22-Sep-22 01:29 AM
I received a million insults in my life
01:30
I don't give a crap
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Cast 22-Sep-22 01:30 AM
Well it is what it is now
01:30
Im gonna try to fix myself as fast as possible
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veganpermanently 22-Sep-22 01:30 AM
it ain't what it used to be
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Cast 22-Sep-22 01:31 AM
Then transfer to a actual university so i can save my social skills
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veganpermanently
it ain't what it used to be
Cast 22-Sep-22 01:31 AM
?
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veganpermanently 22-Sep-22 01:31 AM
I'm pretty sure your insecurities stem from lack of exposure and bad parenting
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Cast 22-Sep-22 01:31 AM
Probably yea
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veganpermanently 22-Sep-22 01:32 AM
u need to exposure yourself to insults more if that hurts you
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veganpermanently
I'm pretty sure your insecurities stem from lack of exposure and bad parenting
CEO 22-Sep-22 01:32 AM
Thoughts on fleshlights
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veganpermanently
u need to exposure yourself to insults more if that hurts you
Cast 22-Sep-22 01:32 AM
Not rlly
01:33
We are talking about like 4-5 years ago
01:33
And it wasnt really just insults
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veganpermanently 22-Sep-22 01:33 AM
yeah the issue is that you stopped receiving insults
01:33
I never did
01:33
that shit hurt me when I was like 5
01:34
at 8 we were already sparring and street fighting all the time
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Cast
And it wasnt really just insults
CEO 22-Sep-22 01:34 AM
Learn how to fight so when they insult you it don’t matter cause you can kick their asses
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veganpermanently 22-Sep-22 01:34 AM
insults were nothing
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MEE6 BOT 22-Sep-22 01:34 AM
@CEO, you have advanced to lvl 5 respect++ emoji_51
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CEO 22-Sep-22 01:34 AM
@ibtisam.midlet fuck you
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Cast 22-Sep-22 01:34 AM
No one really insults me anymore
01:35
And if they do its usually distant
01:35
Or behind my back
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Cast
Or behind my back
veganpermanently 22-Sep-22 01:35 AM
keep it in check
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Cast 22-Sep-22 01:35 AM
But i definetly have a severe issue
01:35
These two girls that have been driving me out of wack
01:35
Both went to my party
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veganpermanently 22-Sep-22 01:35 AM
desensitization is a real thing
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Cast 22-Sep-22 01:36 AM
You know what i originally wantdd
01:36
I wanted it to be just dudes
01:36
I didnt want drama i knew would come
01:36
But my friend insisted he wouldnt give alcohol to a bunch of dudes
01:37
I know everytime women get involved things get ugly
01:37
Atleast for me
01:37
Which is why im like this right now lol
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veganpermanently 22-Sep-22 01:37 AM
rich kids?
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Cast 22-Sep-22 01:37 AM
?
01:38
Maybe its not a bad thing
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veganpermanently 22-Sep-22 01:38 AM
sounds like you're rich kids
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Cast 22-Sep-22 01:38 AM
Middle class
01:38
I need to fix my shit so bad
01:38
Desperately
01:39
I also need a job that involves socializing with lots of people
01:39
Because its the only way im gonna save myself lol
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veganpermanently 22-Sep-22 01:39 AM
satisfy your narcissism
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Cast 22-Sep-22 01:39 AM
?
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veganpermanently 22-Sep-22 01:39 AM
all u do is talk about yourself
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Cast 22-Sep-22 01:40 AM
Yea because im fucked up rn bro
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veganpermanently 22-Sep-22 01:40 AM
https://www.youtube.com/watch?v=7jO92M6mTq4
Blah Records
Danny Lover - Me (Official Music Video)
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CEO 22-Sep-22 01:40 AM
Image attachment
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Cast
Yea because im fucked up rn bro
veganpermanently 22-Sep-22 01:40 AM
you're an attention seeking lil b
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Cast 22-Sep-22 01:40 AM
Im trying to go through a metamorhphesis
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veganpermanently
you're an attention seeking lil b
Cast 22-Sep-22 01:41 AM
I dont give a shit about attention
01:41
I got told before
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Cast
I dont give a shit about attention
veganpermanently 22-Sep-22 01:41 AM
that's surprising
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Cast 22-Sep-22 01:41 AM
About 2 months ago
01:41
My highschool crush
01:41
I saw her at a party
01:42
And i could tell she had no interest in me. Because in her mind i was a loser
01:42
Im gonna stop being a loser
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veganpermanently 22-Sep-22 01:43 AM
vulnerable N
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Cast 22-Sep-22 01:43 AM
Im not a narcissist (edited)
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veganpermanently 22-Sep-22 01:43 AM
switching to grandiose back an forth
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Cast
And i could tell she had no interest in me. Because in her mind i was a loser
ibtisam.midlet 22-Sep-22 01:44 AM
It would have no problem to talk with you even if you are like that
01:44
Don't express much interest
01:45
Max what she would gives will be to be familiar with
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Cast 22-Sep-22 01:45 AM
Honestly i can trace all of this bullshit down to my mother not letting me get my license when i was 17 right before the pandemic
01:46
I didnt get that early independence phase (edited)
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ibtisam.midlet
It would have no problem to talk with you even if you are like that
veganpermanently 22-Sep-22 01:46 AM
the nature of option/opportunity availability
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veganpermanently
the nature of option/opportunity availability
ibtisam.midlet 22-Sep-22 01:46 AM
It was from cuteness nature
01:47
Personally I talk with a lot of people just because it hard to just let them go with ignorant feeling
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ibtisam.midlet
It was from cuteness nature
veganpermanently 22-Sep-22 01:47 AM
why do u think celebrities don't hang with all of their fans all of the time (edited)
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ibtisam.midlet 22-Sep-22 01:48 AM
Even If I unnoticeably threat people as fight or flight response lol
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Cast 22-Sep-22 01:48 AM
I think i can make it
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ibtisam.midlet
Personally I talk with a lot of people just because it hard to just let them go with ignorant feeling
veganpermanently 22-Sep-22 01:48 AM
u mean arrogant?
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Cast 22-Sep-22 01:48 AM
I think i can fix all my bullshit this year and 2023 (edited)
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veganpermanently
u mean arrogant?
ibtisam.midlet 22-Sep-22 01:49 AM
Nope
01:50
I think like behaving good is more important then talking good what you think?
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veganpermanently 22-Sep-22 01:50 AM
ARROGANCE is an attitude of superiority manifested in an overbearing manner or in presumptuous claims or assumptions
01:51
it's funny how Joe 'Not Arrogan' Rogan always plays the humble card
01:52
anyways
01:52
arrogance is rooted in ignorance
01:52
having an ignorant feeling would mean that you know that you don't know much, so it's the opposite of arrogance
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ibtisam.midlet 22-Sep-22 01:57 AM
Isn't ignorant = ignored ?
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Cast 22-Sep-22 02:00 AM
No
02:00
Ignorant = uninformed
02:00
Ignored is a separate word
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ibtisam.midlet 22-Sep-22 02:02 AM
I should stay transplanting EDs
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Cast 22-Sep-22 02:06 AM
Lol imagine this is all a psyop by big tech to make me get betterhelp
02:08
Nvm wtf
02:08
https://youtu.be/uaKGfQoYNFs
BetterHelp
What Is Ethical Non-Monogamy? | BetterHelp
02:08
Not trusting these clowns gad damm
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veganpermanently 22-Sep-22 02:11 AM
monogamy is king
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Cast
Nvm wtf
Yana 22-Sep-22 07:42 AM
What is your big 5 neuroticism 💀
07:42
I think the OCD diagnosis might be accurate
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Yana
What is your big 5 neuroticism 💀
veganpermanently 22-Sep-22 07:43 AM
Why is everybody telling me it's impossible to change those metric
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veganpermanently
Why is everybody telling me it's impossible to change those metric
Yana 22-Sep-22 07:44 AM
Who does everybody consist of
07:44
Surely it's possible
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Yana
Who does everybody consist of
veganpermanently 22-Sep-22 07:44 AM
Nootopics chat emoji_50
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veganpermanently
Nootopics chat emoji_50
Yana 22-Sep-22 07:44 AM
Nemo 975869370045722694
975870265147940914 1
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Yana
Nemo 975869370045722694
veganpermanently 22-Sep-22 07:44 AM
rip
07:45
i like the guy
07:45
but goddamn it man (edited)
07:51
Eucalyptus citriodora is the best oil ever
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Yana
What is your big 5 neuroticism 💀
Cast 22-Sep-22 08:01 AM
Image attachment
08:02
Lowkey wasnt like this last year my neuroticism was my lowest trait
08:08
Ive just been gradually descending into insanity for like no good reason lol
08:14
Also i might not be am introvert but a broken extrovert
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Cast
Ive just been gradually descending into insanity for like no good reason lol
veganpermanently 22-Sep-22 08:15 AM
chloride accumulation
08:15
this correlated with neurogenic use right?
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Cast 22-Sep-22 08:16 AM
Oh yea ive heard that
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MEE6 BOT 22-Sep-22 08:16 AM
@Cast, you have advanced to lvl 13 respect++ emoji_51
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veganpermanently 22-Sep-22 08:16 AM
I told u that 😛
08:16
no one knows about this
emoji_50 1
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Cast 22-Sep-22 08:16 AM
Actually i realized a combo of things have really changed me this summer
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veganpermanently
chloride accumulation
Yana 22-Sep-22 08:16 AM
Is this from GABA-A?
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Yana
Is this from GABA-A?
veganpermanently 22-Sep-22 08:16 AM
it's from exogenously induced BDNF
08:17
I would presume GABA signalling would contribute as well
08:17
at least indirectly
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Cast 22-Sep-22 08:17 AM
Hpw do u reverse it?
08:17
Cardio?
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veganpermanently 22-Sep-22 08:17 AM
yes
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Cast 22-Sep-22 08:17 AM
Is there no other way?
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veganpermanently 22-Sep-22 08:18 AM
endurance exercise as much time as possible in a day
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Cast 22-Sep-22 08:18 AM
Its raining like a bit h rn like it always does the day after i lose my shit
08:18
Weird coincidence
08:19
Jesus Christ im actually insane
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Cast
Its raining like a bit h rn like it always does the day after i lose my shit
veganpermanently 22-Sep-22 08:19 AM
that does sound autistic
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Cast 22-Sep-22 08:19 AM
Im looking back on my thought process yesterday
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veganpermanently 22-Sep-22 08:19 AM
the ambient pressure sensitivity
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Cast 22-Sep-22 08:20 AM
Honestly its been like this for longer
08:20
Manic highs and lows
08:20
I remeber last year too
08:21
But i think its just gotten worse
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veganpermanently 22-Sep-22 08:22 AM
antipsychotic will be an insta fix
08:22
no bueno in the long term tho
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Cast 22-Sep-22 08:22 AM
Its probably not chemical imo
08:22
I think its just due to the pandemic
08:23
Before the pandemic i was actually on a great track in life
08:23
Gad damn wtf
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veganpermanently 22-Sep-22 08:23 AM
everything is chemical
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Cast 22-Sep-22 08:23 AM
Bruh before pandemic i was like getting all my shit together
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veganpermanently 22-Sep-22 08:23 AM
well
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Cast 22-Sep-22 08:23 AM
And i was texting girls confidently
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veganpermanently 22-Sep-22 08:23 AM
electrochemical
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Cast 22-Sep-22 08:23 AM
And not schizoing out
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veganpermanently
the ambient pressure sensitivity
Yana 22-Sep-22 08:24 AM
I've heard that the atmosphere is more hypoxic after/while it rains which is why people like rain emoji_50
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Cast 22-Sep-22 08:24 AM
Mah
08:24
Its like
08:25
For some odd reason when ever something bad happens in my life it rains
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Yana
I've heard that the atmosphere is more hypoxic after/while it rains which is why people like rain emoji_50
Netizenne 22-Sep-22 08:25 AM
I love rain it’s mooooooodyyy
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Cast 22-Sep-22 08:25 AM
And its literally drought season
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Netizenne 22-Sep-22 08:25 AM
such a lush atmosphere (edited)
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Cast 22-Sep-22 08:25 AM
Just so happen to rain like hell
08:25
Whilst i was losing my shit
08:25
I think im hoping realities
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Netizenne
such a lush atmosphere (edited)
Yana 22-Sep-22 08:26 AM
In reality nature isn't all that silent
08:26
Rain drowns out everything else
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Yana
I've heard that the atmosphere is more hypoxic after/while it rains which is why people like rain emoji_50
veganpermanently 22-Sep-22 08:26 AM
I'm just waiting for rain to pass so I can ride
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Yana
Rain drowns out everything else
veganpermanently 22-Sep-22 08:26 AM
the worms
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Netizenne 22-Sep-22 08:26 AM
You would make a good writer jukesta People would mistake your delusions of synchronicity for symbolic motifs and such lol (edited)
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Netizenne
You would make a good writer jukesta People would mistake your delusions of synchronicity for symbolic motifs and such lol (edited)
veganpermanently 22-Sep-22 08:27 AM
you know how in music rain is mentioned a lot
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Cast 22-Sep-22 08:27 AM
I am pretty good at interpreting literature too bad the major journalist of this time are all liberal (edited)
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veganpermanently 22-Sep-22 08:27 AM
asked my shaman friend about it
08:27
he said it's about cleansing
08:27
emoji_50
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Netizenne 22-Sep-22 08:29 AM
Rain is so special I wanna move somewhere it’s always raining so everyday is special too!
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Cast 22-Sep-22 08:29 AM
Damn bro
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Netizenne 22-Sep-22 08:29 AM
moody moody life
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Cast 22-Sep-22 08:29 AM
I need to not be insane
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Cast
I need to not be insane
veganpermanently 22-Sep-22 08:30 AM
go to an asylum
08:30
so we don't have to worry about u
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Cast
I need to not be insane
Yana 22-Sep-22 08:30 AM
I thought this was your latest project
983795135575883818 1
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Cast
I am pretty good at interpreting literature too bad the major journalist of this time are all liberal (edited)
Netizenne 22-Sep-22 08:30 AM
Same, I like to think interpretations one of my stronger skills
08:31
I can usually put together what the author was getting at fairly well
08:32
https://ctlsites.uga.edu/eberle/wp-content/uploads/sites/78/2015/04/Literature-by-Women-2231-2238.pdf We read this rape fan fic in English class recently -only 8 pages (edited)
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Yana
I thought this was your latest project
Cast 22-Sep-22 08:32 AM
Nah
08:32
Psychopaths arent insane
08:33
The noots im all getting rn is to calm my mood and blunt my emotions
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Yana 22-Sep-22 08:33 AM
Finished with my woman 'Cause she couldn't help me with my mind People think I'm insane Because I am frowning all the time All day long I think of things But nothing seems to satisfy Think I'll lose my mind If I don't find something to pacify
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Yana
Finished with my woman 'Cause she couldn't help me with my mind People think I'm insane Because I am frowning all the time All day long I think of things But nothing seems to satisfy Think I'll lose my mind If I don't find something to pacify
Cast 22-Sep-22 08:34 AM
Did u just freestyle that?
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Cast
Psychopaths arent insane
veganpermanently 22-Sep-22 08:34 AM
that moment when she leaves you for another
08:34
ur gonna put her on a stick
08:34
and yourself in a lifetime
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veganpermanently
that moment when she leaves you for another
Cast 22-Sep-22 08:34 AM
Ill go for her mother
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Cast
Did u just freestyle that?
Yana 22-Sep-22 08:34 AM
Unfortunately I am not ozzy osbourne
despair 1
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Cast 22-Sep-22 08:35 AM
Good shit tho
08:35
What do u think of my stack yana?
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Yana 22-Sep-22 08:35 AM
Where
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Cast 22-Sep-22 08:35 AM
Kanna + NAC + ashwaganda
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Yana 22-Sep-22 08:36 AM
975869370045722694
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Cast 22-Sep-22 08:36 AM
Wut
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Netizenne 22-Sep-22 08:36 AM
Emojis I should add to server later: Love Heartsunken Prayge REAL Heartheld ringohop bigbrain boywave Zoloft lainsitcry Grin Trollnt ultrabrain notetake xd Yayayayaya Crybb Baddrugs nepxd
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Cast 22-Sep-22 08:37 AM
Nice
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Netizenne
Emojis I should add to server later: Love Heartsunken Prayge REAL Heartheld ringohop bigbrain boywave Zoloft lainsitcry Grin Trollnt ultrabrain notetake xd Yayayayaya Crybb Baddrugs nepxd
veganpermanently 22-Sep-22 08:38 AM
semme pngs
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Netizenne 22-Sep-22 08:42 AM
some other for consideration: AigisJam Angelmode Burimunchi Buwush Comfsmugfeel Dazed Drawnheart Drinking DxM EVILMAXXED Ebilsleepi Ebilsnikker Ehehehehehehehehe EvilUwU Eyeofhorus FAKE Fangs Flanflanflan Flashes Flusty Frien Groovin Havautizm Hyper KEKEKEKEKEK Kissing LSD Lickyy Lookoutsideyourwindow Mikucat MonsterEnergy Necoarccheers Necodance Nekosob NikolaiMoment Padarou Remigrr Remijoy Schizoattack Smiley Smuggy This YAAAAYYYY mmmMMMmmm
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Cast 22-Sep-22 08:42 AM
Ah shit i was so wrong
08:42
I was just as neurotic last year
08:43
I was like christian back then or just pretending to be christian to cope
08:43
And i would blame demons lol
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Netizenne 22-Sep-22 08:43 AM
Ibti don’t just rip these ones -I’ll share larger versions we can rip later (edited)
👍 1
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veganpermanently 22-Sep-22 08:45 AM
Image attachment
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Netizenne
some other for consideration: AigisJam Angelmode Burimunchi Buwush Comfsmugfeel Dazed Drawnheart Drinking DxM EVILMAXXED Ebilsleepi Ebilsnikker Ehehehehehehehehe EvilUwU Eyeofhorus FAKE Fangs Flanflanflan Flashes Flusty Frien Groovin Havautizm Hyper KEKEKEKEKEK Kissing LSD Lickyy Lookoutsideyourwindow Mikucat MonsterEnergy Necoarccheers Necodance Nekosob NikolaiMoment Padarou Remigrr Remijoy Schizoattack Smiley Smuggy This YAAAAYYYY mmmMMMmmm
veganpermanently 22-Sep-22 08:49 AM
Gimme your most psychedelic emoji
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Netizenne 22-Sep-22 09:01 AM
Idk if I have that many very trippy emojis Angelmode Palm Tunnelvision Wavy (edited)
09:01
My old account which was in the cool servers was deleted and idk how to get back to them despair
ibtisam.midlet pinned a message to this channel. 22-Sep-22 09:16 AM
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Cast
Psychopaths arent insane
Pax1l 22-Sep-22 09:20 AM
I think we should start self reflecting
09:20
Take care of yourself
09:21
https://www.psypost.org/2022/09/dark-personality-traits-linked-to-a-greater-desire-to-enhance-oneself-using-technological-methods-63946
Eric W. Dolan
Dark personality traits linked to a greater desire to enhance onese...
People with dark personality traits are more likely to want to enhance their brain power with futuristic technologies, according to new research published in the Journal of Cognitive Enhancement. ...
Thumbnail
09:21
Never seen a more transparent psy op
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Pax1l
https://www.psypost.org/2022/09/dark-personality-traits-linked-to-a-greater-desire-to-enhance-oneself-using-technological-methods-63946
veganpermanently 22-Sep-22 09:22 AM
should probably keep our biohacking efforts to ourselves bcs of this article
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Pax1l 22-Sep-22 09:23 AM
Weve done a good enough job of it already over the last year and a half
09:24
We should have a system that can incorporate new members through multiple outlets
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veganpermanently 22-Sep-22 09:24 AM
I realized this recently
09:25
bcs I noticed some 'friends' saw this article and psychologized me
09:25
covertly ofc
09:25
who's the psycho now eh
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Pax1l 22-Sep-22 09:26 AM
Maybe theyre just stupid
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Cast 22-Sep-22 09:26 AM
Lol fr
09:26
Im nothing like my discord personality irl
09:26
Irl people describe me as humble and introverted
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Pax1l 22-Sep-22 09:27 AM
No that really is what you sound like
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Cast 22-Sep-22 09:27 AM
Yea
09:27
But alot of people on discord accuse me of being egotistical and narcissistic (edited)
09:27
Like sirsad lol
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veganpermanently 22-Sep-22 09:28 AM
u do have an overt display of narcissistic qualities
09:28
shifting from vulnerable to grandiose
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Pax1l 22-Sep-22 09:28 AM
I think youre pretty self conscious and project yourself to protect your ego
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MEE6 BOT 22-Sep-22 09:28 AM
@Pax1l, you have advanced to lvl 9 respect++ emoji_51
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Cast 22-Sep-22 09:29 AM
Its just discord honestly
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veganpermanently 22-Sep-22 09:29 AM
tho I don't think anyone here is narcissist
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Cast 22-Sep-22 09:29 AM
Brings out the worst in everyone
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veganpermanently 22-Sep-22 09:29 AM
those people don't use discord
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Cast 22-Sep-22 09:29 AM
Eh I disagree
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veganpermanently 22-Sep-22 09:30 AM
you can't feed insecurities with social media
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Cast 22-Sep-22 09:30 AM
Ive seen more narcissistic people on social media
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veganpermanently
you can't feed insecurities with social media
Cast 22-Sep-22 09:30 AM
Yea
09:31
Instagram for one is a breeding ground of narcissism
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Cast
Its just discord honestly
Pax1l 22-Sep-22 09:31 AM
If a few of us decided to form study groups that were organized around neuroscience and literature that was presented and not trying to interject our own thoughts then a lot more of us will learn valuable information that will benefit us
emoji_7 2
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veganpermanently 22-Sep-22 09:31 AM
I know a few narcissists both cover and overt, both grandiose and vulnerable and cycling
09:31
none of them use social media
09:31
they don't know how to
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Cast 22-Sep-22 09:32 AM
Wtf
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Cast
Brings out the worst in everyone
brothermanbill 22-Sep-22 09:32 AM
Socializing by text brings the worst out of everyone? Maybe for you it does
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veganpermanently 22-Sep-22 09:32 AM
because they're so dependent on validation they need to see it on a person's face in real time
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Cast 22-Sep-22 09:32 AM
I guess thats an older generation thing
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Pax1l 22-Sep-22 09:32 AM
Oh hey its brothermanbill the person that wanted to just tell me that i should starve and provide research for free and noots at cost so that they can satisfy their drug addiction
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brothermanbill 22-Sep-22 09:33 AM
Exactly. Go smoke meth with ur mother
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brothermanbill
Exactly. Go smoke meth with ur mother
veganpermanently 22-Sep-22 09:33 AM
yo wtf
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Cast 22-Sep-22 09:33 AM
Oh boy
09:33
Two people that cannot be in the same server lol (edited)
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Pax1l 22-Sep-22 09:34 AM
This community would not have a large portion of the drugs or research available to us if it were not for my work
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veganpermanently 22-Sep-22 09:34 AM
snap it
09:34
WAKE UP
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Pax1l 22-Sep-22 09:35 AM
Ive done everything i could so that you can improve as a person and you think that any supplier in the community is supposed to treat this pursuit like they should go broke for a hobby
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Pax1l
Ive done everything i could so that you can improve as a person and you think that any supplier in the community is supposed to treat this pursuit like they should go broke for a hobby
veganpermanently 22-Sep-22 09:36 AM
who gives a f what other ppl think
09:36
charge whatever you want for whatever you want
09:36
if they wanna buy good
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Pax1l 22-Sep-22 09:37 AM
If you think you can do it better then live up to your delusional idea of acting in the good of everyone and not make a dime off your contribution @brothermanbill
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veganpermanently 22-Sep-22 09:38 AM
I had ppl talk to me like that b4 too
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veganpermanently
if they wanna buy good
Pax1l 22-Sep-22 09:38 AM
The point is brotherman bill at nearly everytime i see him mentions i need to make some conjugate or synth some drug and i say to him well if you want it then put up some money
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veganpermanently
charge whatever you want for whatever you want
brothermanbill 22-Sep-22 09:38 AM
Yeah that is perfectly fine. You should have seen how he came across though. Like a Narcissist Straight asshole fucktard. You can make money and not be an asshole to people.
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veganpermanently 22-Sep-22 09:38 AM
trying to insult me because I down wanna talk to them if they don't pay up
09:39
like bitch why so entitled
09:39
but who cares
09:39
I block them and move on
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brothermanbill
Yeah that is perfectly fine. You should have seen how he came across though. Like a Narcissist Straight asshole fucktard. You can make money and not be an asshole to people.
Pax1l 22-Sep-22 09:39 AM
You took every opportunity to mention conjugates or mw making an exotic drug and said that you wouldnt want to put any money into my work
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veganpermanently 22-Sep-22 09:40 AM
so now you invented the concept of a hybrid drug
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Pax1l 22-Sep-22 09:40 AM
I will show everyone in this goddamn chat the whole chat log if youre so inclined
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Pax1l
If you think you can do it better then live up to your delusional idea of acting in the good of everyone and not make a dime off your contribution @brothermanbill
brothermanbill 22-Sep-22 09:41 AM
I don’t care about “doing better” i attract people towards peptide synth and we do group buy where everyone pays the same so we get better deals with more people contributing
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veganpermanently
so now you invented the concept of a hybrid drug
Pax1l 22-Sep-22 09:41 AM
Brotherman bill is like make a conjugate of this plus this several times a fucking month (edited)
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Cast
Brings out the worst in everyone
Netizenne 22-Sep-22 09:41 AM
Idk about that You just have to be extra expressive where you can to compensate for the lack of dimension elsewhere How text communication goes (edited)
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Pax1l
Brotherman bill is like make a conjugate of this plus this several times a fucking month (edited)
veganpermanently 22-Sep-22 09:41 AM
what does that mean
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Pax1l
You took every opportunity to mention conjugates or mw making an exotic drug and said that you wouldnt want to put any money into my work
brothermanbill 22-Sep-22 09:41 AM
Its funny how you only targeted me to give you money. Literally no one else. Weird ass hag
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Netizenne
Idk about that You just have to be extra expressive where you can to compensate for the lack of dimension elsewhere How text communication goes (edited)
veganpermanently 22-Sep-22 09:42 AM
dimension
09:42
what a word to use
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brothermanbill
Its funny how you only targeted me to give you money. Literally no one else. Weird ass hag
Pax1l 22-Sep-22 09:42 AM
You are the only fucking person that asks for synths every time you come into chat
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JK 22-Sep-22 09:42 AM
Argue in DM guys
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veganpermanently
dimension
Netizenne 22-Sep-22 09:42 AM
There’s like different axis of communication. Body language, intonation, how you dress even communicates a lot about you. Only thing you have with discord is what you say -it’s like having to strain all our personality through just the one axis of dimension. (edited)
💯 1
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MEE6 BOT 22-Sep-22 09:42 AM
@Netizenne, you have advanced to lvl 13 respect++ emoji_51
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Pax1l 22-Sep-22 09:43 AM
No i will not do groupbuys no i will not hold myself accountable financially to other fucling people to expose me to more risk and to use up my time just so you can fucking benefit
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Netizenne
There’s like different axis of communication. Body language, intonation, how you dress even communicates a lot about you. Only thing you have with discord is what you say -it’s like having to strain all our personality through just the one axis of dimension. (edited)
JK 22-Sep-22 09:44 AM
Are you familiar with jean baudrillard post structuralism?
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Netizenne 22-Sep-22 09:44 AM
No
09:44
Maybe through cultural diffusion tho
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Netizenne
There’s like different axis of communication. Body language, intonation, how you dress even communicates a lot about you. Only thing you have with discord is what you say -it’s like having to strain all our personality through just the one axis of dimension. (edited)
veganpermanently 22-Sep-22 09:44 AM
I need to start sewing asap
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Cast
But alot of people on discord accuse me of being egotistical and narcissistic (edited)
blank 22-Sep-22 09:45 AM
maybe because you behave completely differently in nootopics and rest of the nootropics servers
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veganpermanently 22-Sep-22 09:45 AM
hate fashion but that's only because I know better
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JK 22-Sep-22 09:45 AM
I think his work would interest you, specifically with regards to how we cloth ourselves in accordance of what we want to communicate and or signal (edited)
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Netizenne 22-Sep-22 09:46 AM
I don’t understand how you guys could have an issue with Jukesta and not someone else like say LEL for example
09:46
way more of a nuissance (not that I really find jukesta one at all) (edited)
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Pax1l 22-Sep-22 09:46 AM
The world doesnt fucking work that way. Im not going to take out my time to advertise a fucking drug again to get a groupbuy together just so you and others can just say wow thanks and i never get even recognition from that you entitled dick
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Netizenne
I don’t understand how you guys could have an issue with Jukesta and not someone else like say LEL for example
veganpermanently 22-Sep-22 09:47 AM
that man is on my blocklist for a year or more
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Netizenne
I don’t understand how you guys could have an issue with Jukesta and not someone else like say LEL for example
blank 22-Sep-22 09:47 AM
LEL is actually smart that's the difference
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veganpermanently 22-Sep-22 09:47 AM
when it comes to nootopics it's pretty obvious
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Pax1l
The world doesnt fucking work that way. Im not going to take out my time to advertise a fucking drug again to get a groupbuy together just so you and others can just say wow thanks and i never get even recognition from that you entitled dick
brothermanbill 22-Sep-22 09:48 AM
No one will want to do group buy with you if you act like a dick towards them. Like you want them to worship your cock for doing this.
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veganpermanently 22-Sep-22 09:48 AM
any one that has possible power over sirsa will get booted for one reason or the other
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JK 22-Sep-22 09:48 AM
https://semio2014.org/en/design-semiotics-and-post-structuralism
Design Semiotics and Post-Structuralism
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brothermanbill
No one will want to do group buy with you if you act like a dick towards them. Like you want them to worship your cock for doing this.
Pax1l 22-Sep-22 09:49 AM
Im never going to do a fucking groupbuy so that im holding onto other peoples fucking money and im pressured by the timetable of a fucking lab so that i can ship compounds through the mail you midwit
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veganpermanently 22-Sep-22 09:49 AM
ye fuck a groupbuy
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Pax1l
Im never going to do a fucking groupbuy so that im holding onto other peoples fucking money and im pressured by the timetable of a fucking lab so that i can ship compounds through the mail you midwit
Potential 22-Sep-22 09:50 AM
Fair point to be honest.
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veganpermanently 22-Sep-22 09:50 AM
buy the product and sell it like any drug dealer
09:50
buy low sell high
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Potential 22-Sep-22 09:51 AM
Some people are comfortable with that, some people aren't.
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Pax1l
Im never going to do a fucking groupbuy so that im holding onto other peoples fucking money and im pressured by the timetable of a fucking lab so that i can ship compounds through the mail you midwit
brothermanbill 22-Sep-22 09:51 AM
But you wanted thousands of dollars from me upfront for your little silly peptides
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Potential
Fair point to be honest.
Pax1l 22-Sep-22 09:52 AM
Cogmetics, gintrux, the kid that had a lab in a fucking storage locker. How many people in the community actually have fallen short on time tables or literally ran away with money
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brothermanbill
But you wanted thousands of dollars from me upfront for your little silly peptides
veganpermanently 22-Sep-22 09:52 AM
the issue is that they're not little
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brothermanbill
But you wanted thousands of dollars from me upfront for your little silly peptides
Pax1l 22-Sep-22 09:52 AM
Do you realize how much drugs cost
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Netizenne 22-Sep-22 09:52 AM
I guess I’m the moderator here If anyone thinks I should step in and do something dm me suggestions
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Pax1l
Cogmetics, gintrux, the kid that had a lab in a fucking storage locker. How many people in the community actually have fallen short on time tables or literally ran away with money
veganpermanently 22-Sep-22 09:52 AM
gintruxx ran away?
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Pax1l
Cogmetics, gintrux, the kid that had a lab in a fucking storage locker. How many people in the community actually have fallen short on time tables or literally ran away with money
Potential 22-Sep-22 09:52 AM
I am also a moderator
09:53
This is entertaining
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Netizenne 22-Sep-22 09:53 AM
I’m not sure what sorta policy to have about this Maybe we should let them settle things and work towards some sorta resolution? I don’t really have the attention span to see if things are getting better or worse tho
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Potential 22-Sep-22 09:53 AM
Let's just keep it relatively respectful.
✅ 1
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Pax1l
Do you realize how much drugs cost
brothermanbill 22-Sep-22 09:54 AM
Hahahhaha we are going in rotation again over this. You need to find a bill gates buddy. Or you need to take a loan. The average discord user isn’t going to give you thousands just for making a peptide that could take months
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Potential
Let's just keep it relatively respectful.
CEO 22-Sep-22 09:54 AM
Listen buddy once pax and Brotherman are done arguing me and you are next
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Potential
Let's just keep it relatively respectful.
Netizenne 22-Sep-22 09:54 AM
Ya let’s not be needlessly inflammatory
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Potential 22-Sep-22 09:54 AM
I propose a public debate.
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veganpermanently
gintruxx ran away?
Pax1l 22-Sep-22 09:55 AM
No its just they were pressured because it took the lab 4 months to finish a synth of a groupbuy that shouldve been finished organizing within 3 weeks or less but it took 2 months and then we got a $7k moq and didnt ask for any margin on the buy
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brothermanbill
Hahahhaha we are going in rotation again over this. You need to find a bill gates buddy. Or you need to take a loan. The average discord user isn’t going to give you thousands just for making a peptide that could take months
veganpermanently 22-Sep-22 09:55 AM
we need a maecena yes
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brothermanbill
Hahahhaha we are going in rotation again over this. You need to find a bill gates buddy. Or you need to take a loan. The average discord user isn’t going to give you thousands just for making a peptide that could take months
Pax1l 22-Sep-22 09:55 AM
Im not going to take a loan just so your fucking broke ass to tell me that you can just do better literally fuck off you schizo
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veganpermanently 22-Sep-22 09:56 AM
we should do some outreach
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CEO
Listen buddy once pax and Brotherman are done arguing me and you are next
Potential 22-Sep-22 09:56 AM
You're on 🍬
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JK
https://semio2014.org/en/design-semiotics-and-post-structuralism
Netizenne 22-Sep-22 09:56 AM
Reading is for untermensch lol
emoji_51 1
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Potential
I propose a public debate.
TreeSlayer 22-Sep-22 09:56 AM
Debates are stupid, discussion are what you need
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MEE6 BOT 22-Sep-22 09:56 AM
@TreeSlayer, you have advanced to lvl 1 respect++ emoji_51
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TreeSlayer
Debates are stupid, discussion are what you need
Potential 22-Sep-22 09:57 AM
I think we have different definitions of what a "debate" is.
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Netizenne 22-Sep-22 09:58 AM
Dialectics > debate
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Potential
I think we have different definitions of what a "debate" is.
TreeSlayer 22-Sep-22 09:58 AM
A debate is 2 opposing sides trying to convince the other that they are right
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TreeSlayer
A debate is 2 opposing sides trying to convince the other that they are right
Potential 22-Sep-22 09:58 AM
Nope.
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Potential
Nope.
TreeSlayer 22-Sep-22 09:58 AM
Yes
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JK 22-Sep-22 09:59 AM
Keep it somewhat Socratic and you can debate/argue as much to your liking
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CEO 22-Sep-22 09:59 AM
Who’s side are you guys on? Brotherman or pax ?
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Pax1l 22-Sep-22 09:59 AM
Brotherman bill thinks i should just buy drugs outfront with a loan with the expectation that people will be gracious and plentiful enough to actually want to buy from me
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TreeSlayer
Yes
Potential 22-Sep-22 09:59 AM
"a formal discussion on a particular matter in a public meeting or legislative assembly, in which opposing arguments are put forward and which usually ends with a vote."
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JK
Keep it somewhat Socratic and you can debate/argue as much to your liking
veganpermanently 22-Sep-22 10:00 AM
why is the Socratic approach more valuable then simply stating the opinion without circumlocution?
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CEO
Who’s side are you guys on? Brotherman or pax ?
Pax1l 22-Sep-22 10:00 AM
His reasoning is just "dont expect me to go out of my way to contribute in any significant way financially even if i ask for drug synths
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Netizenne 22-Sep-22 10:00 AM
You guys wanna start a thread maybe?
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TreeSlayer 22-Sep-22 10:00 AM
Image attachment
10:00
Handy chart
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Netizenne 22-Sep-22 10:00 AM
Debate: to take the responsibility of group buys or not
☝️ 1
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TreeSlayer 22-Sep-22 10:01 AM
a debate is about wining and proving you're right
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Potential 22-Sep-22 10:01 AM
It's about convincing the audience
10:01
Not the opposing side
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Netizenne
Debate: to take the responsibility of group buys or not
Netizenne 22-Sep-22 10:01 AM
Okay keep it contained guys
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Potential 22-Sep-22 10:01 AM
Each side represents a different argument
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MEE6 BOT 22-Sep-22 10:01 AM
@brothermanbill, you have advanced to lvl 4 respect++ emoji_51
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TreeSlayer
a debate is about wining and proving you're right
veganpermanently 22-Sep-22 10:01 AM
do you know about sociocratic decision making
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TreeSlayer 22-Sep-22 10:02 AM
A discussion is about learning and contributing to knowledge within the group
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Netizenne 22-Sep-22 10:02 AM
Imma delete whatever isnt in the right place now
10:02
From this point on
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JK
Are you familiar with jean baudrillard post structuralism?
Yana 22-Sep-22 10:02 AM
Yeh
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Netizenne
Imma delete whatever isnt in the right place now
veganpermanently 22-Sep-22 10:02 AM
THOR'S HAMMER HAS ARRIVED, BRACE YOURSELVES MORTALS
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veganpermanently
why is the Socratic approach more valuable then simply stating the opinion without circumlocution?
JK 22-Sep-22 10:02 AM
It’s just a method of determining how accurate and helpful certain thoughts may be. Like the amount of ad hominems by now is beyond sufficient.. Doesn’t mean it needs to be a wordsalat (edited)
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komodo dragon 22-Sep-22 10:02 AM
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Netizenne 22-Sep-22 10:09 AM
Sorry guys pls use thread
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Pax1l 22-Sep-22 10:09 AM
Hey maybe its a good idea to keep a record of those messages
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Netizenne 22-Sep-22 10:10 AM
I know but I did let you know it would happen
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Pax1l 22-Sep-22 10:11 AM
No you just deleted evidence of a threat to use violence against me with the mention of personal information against me
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ibtisam.midlet 22-Sep-22 10:11 AM
net dms
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ibtisam.midlet
net dms
CEO 22-Sep-22 10:12 AM
Where you from
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ibtisam.midlet
net dms
Pax1l 22-Sep-22 10:13 AM
I dmed them and they didnt mention that they were going to just delete a record of threatening violence against me
10:13
What kind of server do you run?
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Pax1l
I dmed them and they didnt mention that they were going to just delete a record of threatening violence against me
ibtisam.midlet 22-Sep-22 10:14 AM
let him do what he want
10:14
it was good willing if you think twice
10:14
and also yours will deleted sure
10:15
take screen shorts ill not delet fastly
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Pax1l 22-Sep-22 10:15 AM
Its literally a violation of discord tos
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ibtisam.midlet 22-Sep-22 10:16 AM
if we deleted a threat
10:16
pax i said before stop seeking understandment trying to make your self seen as good person
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Pax1l 22-Sep-22 10:16 AM
Wowee get threatened with violence and your personal information shared and nothing happens🙃
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Pax1l
I dmed them and they didnt mention that they were going to just delete a record of threatening violence against me
Netizenne 22-Sep-22 10:17 AM
I told you I would jeez guys
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Potential 22-Sep-22 10:17 AM
@Pax1l Didn't you threaten Cogmetics on multiple occasions. Or was it that both of you threatened each other.
10:17
🤔
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Potential
@Pax1l Didn't you threaten Cogmetics on multiple occasions. Or was it that both of you threatened each other.
Pax1l 22-Sep-22 10:17 AM
Dude took 9k dollars from me
Eyespop 1
10:18
And i said i would expose him for being a fraud
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Potential 22-Sep-22 10:18 AM
He stole the money?
10:18
This wasn't for a synth that is still happening or something?
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Pax1l 22-Sep-22 10:18 AM
Well he didnt give me things like respect or follow through with his obligations
10:19
All of you forget that i contributed more money financially for the development of new drugs than most of you combined
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Netizenne 22-Sep-22 10:20 AM
Personally I don’t like how brotherman thinks you should take up that sort of responsibility, you shouldn’t have such weights pressured upon you
10:21
Why haven’t they organized a group buy themselves?
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Pax1l
All of you forget that i contributed more money financially for the development of new drugs than most of you combined
Potential 22-Sep-22 10:21 AM
I don't know how this is relevant right now?
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Potential
I don't know how this is relevant right now?
Pax1l 22-Sep-22 10:21 AM
You asked me about cogmetics
10:22
Pretty topical and relevant to why i think maybe i am more entitled to financial support for the quality of research advocacy and compounds i have put forward
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Netizenne 22-Sep-22 10:22 AM
Do you guys think maybe people argue when they get bored for the sake of sharpening their wit -as a form of mental exercise maybe?
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Pax1l 22-Sep-22 10:23 AM
Brotherman bill literally says my name, and threatens to go to my home town and open my head with a claw hammer
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Netizenne 22-Sep-22 10:23 AM
It’s technically illegal to threaten murder
10:24
You guys should keep in mind
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Pax1l
You asked me about cogmetics
Potential 22-Sep-22 10:24 AM
It sounded pretentious but I could have misinterpreted it. 👍 I don't see the point in you boasting about your achievements. You have a server that is dedicated to you and there you are to be admired. Here we are equals.
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Pax1l
Dude took 9k dollars from me
brothermanbill 22-Sep-22 10:25 AM
Thats not what he told us. It was you bashing his works and ideas that you didn’t want to contribute towards. Cogmetics went on a long rant about this and you are just making people believe your inaccurate side of the story
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Netizenne 22-Sep-22 10:25 AM
Why don’t you guys use a thread
💟 1
10:25
?
10:25
Is there a reason I am missing?
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Pax1l
Brotherman bill literally says my name, and threatens to go to my home town and open my head with a claw hammer
brothermanbill 22-Sep-22 10:26 AM
See, trying to get people in trouble over make-believe stories. Smh get a life, you live in a fairytale you schizo. Make a thread for my name and stop polluting this chat with your nonsense. I am done here. Don’t mention my name again
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Potential 22-Sep-22 10:26 AM
It is true that Cogmetics has his own perspective on this thing and he would deny these accusations. .
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brothermanbill
Thats not what he told us. It was you bashing his works and ideas that you didn’t want to contribute towards. Cogmetics went on a long rant about this and you are just making people believe your inaccurate side of the story
Pax1l 22-Sep-22 10:26 AM
I literally gave him $6k so i could have a drug made and he prioritized his own work, then i gave him money so he wouldnt go homeless, then i supported hap6 and d21 and never gotten respect for it
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brothermanbill
See, trying to get people in trouble over make-believe stories. Smh get a life, you live in a fairytale you schizo. Make a thread for my name and stop polluting this chat with your nonsense. I am done here. Don’t mention my name again
Netizenne 22-Sep-22 10:27 AM
Needlessly inflammatory smh
10:27
chill ppl
10:27
be nice!!!!!
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brothermanbill
See, trying to get people in trouble over make-believe stories. Smh get a life, you live in a fairytale you schizo. Make a thread for my name and stop polluting this chat with your nonsense. I am done here. Don’t mention my name again
Pax1l 22-Sep-22 10:27 AM
Ill keep this in mind when i mention you in the future emphasizing that youre going to come to my town and kill me
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Netizenne 22-Sep-22 10:27 AM
Always be nice!!!!
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Potential 22-Sep-22 10:27 AM
All of the DM'S between you guys would need to be leaked for the whole truth to be out there.
emoji_1 1
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Pax1l
I literally gave him $6k so i could have a drug made and he prioritized his own work, then i gave him money so he wouldnt go homeless, then i supported hap6 and d21 and never gotten respect for it
brothermanbill 22-Sep-22 10:27 AM
You tried to over-ride his work. And you wanted accountability over being the leader of the group. You are desperate for power, its toxic
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Potential
All of the DM'S between you guys would need to be leaked for the whole truth to be out there.
Pax1l 22-Sep-22 10:28 AM
We argued in the insulin chat in my server
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brothermanbill
You tried to over-ride his work. And you wanted accountability over being the leader of the group. You are desperate for power, its toxic
Pax1l 22-Sep-22 10:28 AM
Dude you threatened to kill me
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Pax1l
Ill keep this in mind when i mention you in the future emphasizing that youre going to come to my town and kill me
brothermanbill 22-Sep-22 10:28 AM
Schizo thoughts. Smh. Thinking people are out to kill you. Pop a seroquel brotha
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Pax1l
We argued in the insulin chat in my server
Potential 22-Sep-22 10:29 AM
I will check that out ✅
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brothermanbill
You tried to over-ride his work. And you wanted accountability over being the leader of the group. You are desperate for power, its toxic
Pax1l 22-Sep-22 10:29 AM
I gave him money to make octreotide hylauronate and i literally have on record someone that gave themselves braindamage with hafgl
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Netizenne 22-Sep-22 10:29 AM
Personally I like to read through all the past messages while I’m away I like to keep up with what happened in chat while I was away Only reason I ask for a thread Well, also cause for some conflict can be vicariously stressful
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brothermanbill
Schizo thoughts. Smh. Thinking people are out to kill you. Pop a seroquel brotha
Pax1l 22-Sep-22 10:30 AM
You threatened me in this chat
10:30
Everyone present can back that up
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Netizenne 22-Sep-22 10:30 AM
Potential you’ve been watching Did you see it?
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Potential 22-Sep-22 10:30 AM
@brothermanbill How certain are you in these accusations?
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Pax1l
I gave him money to make octreotide hylauronate and i literally have on record someone that gave themselves braindamage with hafgl
brothermanbill 22-Sep-22 10:30 AM
That someone is you. You made an impersation of a fake person getting brain damage. We all know how you work things out to get others hurt or lessen credibility of others works just because you don’t have the upper hand in the situation
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Netizenne
Potential you’ve been watching Did you see it?
Potential 22-Sep-22 10:31 AM
Yes, something along those lines.
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MEE6 BOT 22-Sep-22 10:31 AM
@Potential, you have advanced to lvl 7 respect++ emoji_51
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brothermanbill
That someone is you. You made an impersation of a fake person getting brain damage. We all know how you work things out to get others hurt or lessen credibility of others works just because you don’t have the upper hand in the situation
Pax1l 22-Sep-22 10:32 AM
Youre someone that has taken way too many noots and thinks you can just threaten me or others acting in good conscience
emoji_6 1
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Pax1l
You threatened me in this chat
brothermanbill 22-Sep-22 10:32 AM
You have no evidence. Yet i have evidence of you threatening me over money. You burglar.
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Netizenne 22-Sep-22 10:33 AM
Everyone here can die a flaming torturous death To the pits of hellfire and agony you all go Scream in pain for eternity for the suffering you wrought upon yourselves Kill yourselves the all of you, murder everyone you know along with it, burn yourselves in fiery oil and drown in your own piss Go rot in some ditch
10:34
Beasts of people
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Netizenne
Beasts of people
blank 22-Sep-22 10:34 AM
Ban
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Pax1l 22-Sep-22 10:34 AM
No youre an entitled person that thinks that you can just tell yourself that youre acting for the good of everyone by acting like a communist
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Potential 22-Sep-22 10:34 AM
@Netizenne Poetry for the soul. 🍬
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blank 22-Sep-22 10:35 AM
https://discord.com/channels/1001420842179239936/1001853526495997972/1020452407613857803
🏳️‍🌈 1
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Potential
@Netizenne Poetry for the soul. 🍬
Netizenne 22-Sep-22 10:35 AM
You have the potential to grab the knife and do it all yourself if you wish
👀 1
10:35
Free the humours with a freely humour
10:36
Feel the wrath of your ignorant stupor
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blank
https://discord.com/channels/1001420842179239936/1001853526495997972/1020452407613857803
Man2 22-Sep-22 10:37 AM
so brave
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MEE6 BOT 22-Sep-22 10:37 AM
@Man2, you have advanced to lvl 1 respect++ emoji_51
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Netizenne 22-Sep-22 10:37 AM
bruh 1
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Potential 22-Sep-22 10:38 AM
@Pax1l @brothermanbill Submit the receipts 🧾 Everything you have.
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Netizenne 22-Sep-22 10:38 AM
Image attachment
10:38
Chat be so violent and horrific to eachother Awwwhhh
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Man2 22-Sep-22 10:38 AM
recipts
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Netizenne 22-Sep-22 10:39 AM
Grin
10:39
Only evil now
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Man2 22-Sep-22 10:39 AM
fite
10:39
fite
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Netizenne 22-Sep-22 10:39 AM
No more nice
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Man2 22-Sep-22 10:39 AM
fite
10:39
fite
10:39
bill v pax
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Netizenne 22-Sep-22 10:40 AM
Endless suffering for all
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Man2 22-Sep-22 10:40 AM
Kekw
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Netizenne 22-Sep-22 10:40 AM
Don’t be so greedy with your misery
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Man2 22-Sep-22 10:40 AM
i bought nitro for this emoji
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Man2
i bought nitro for this emoji
CEO 22-Sep-22 10:40 AM
Pathetic
cutepepe 1
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Pax1l
No youre an entitled person that thinks that you can just tell yourself that youre acting for the good of everyone by acting like a communist
brothermanbill 22-Sep-22 10:41 AM
At least i don’t threaten people for money amirite
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Potential 22-Sep-22 10:41 AM
@CEO you have a receipt 🧾?
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CEO
Pathetic
Man2 22-Sep-22 10:41 AM
fucking fight me
10:41
this is the fight server
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veganpermanently 22-Sep-22 10:42 AM
gimme all the scripts
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CEO 22-Sep-22 10:42 AM
emoji_50
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ibtisam.midlet 22-Sep-22 10:42 AM
@Lux ✨ join the party
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Netizenne 22-Sep-22 10:42 AM
Arguing is probably good for the wit but don’t burn bridges and remember you can always return reborn through forgiveness like Jesus if you disappear for a few months and change your demeanour on re-entry
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CEO 22-Sep-22 10:42 AM
@Lux ✨ moron
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ibtisam.midlet
@Lux ✨ join the party
veganpermanently 22-Sep-22 10:43 AM
yo imagine how hilarious would it be if we all attended a party anonymously
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Netizenne 22-Sep-22 10:43 AM
Not enough forgiveness these days smh
10:43
Y’all need Jesus
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veganpermanently 22-Sep-22 10:44 AM
Jesus thing is a scam
emoji_52 1
10:44
the ressurection
10:44
muslims have it right
10:44
1-1 is 0 every time
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JK 22-Sep-22 10:45 AM
I’ve been isolated in a cave siince early Covid.
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Netizenne 22-Sep-22 10:45 AM
Jesus was a role model He taught people to be forgiving We spend thousands of years co-evolving with vitamin c in our diet and eventually we lose the ability to synthesize it ourselves
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JK 22-Sep-22 10:45 AM
Gabriel taking a fucking decade off?
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Netizenne 22-Sep-22 10:45 AM
We co-evolved with Christianity for long enough I think it left a mark upon us
10:45
Imo
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Netizenne
We co-evolved with Christianity for long enough I think it left a mark upon us
veganpermanently 22-Sep-22 10:45 AM
Early christianity was rock and roll
🤣 2
10:46
after that it's just manipulation
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veganpermanently
1-1 is 0 every time
Netizenne 22-Sep-22 10:46 AM
Even if so I think people tend to want take two eyes in return with the way people act (edited)
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Netizenne
Even if so I think people tend to want take two eyes in return with the way people act (edited)
veganpermanently 22-Sep-22 10:46 AM
I didn't mean that
10:47
I meant if you do a wrong thing, then do a good thing to make up for it, no one is going to hold grudges unless they're an idiot
10:47
but if you do a wrong thing then repent ain't gonna help nobody
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Netizenne 22-Sep-22 10:47 AM
Even if Christianity was only adopted and spread by Rome to help increase cohesion amoung its many newly conquered tribes we still co-evolved with it
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brothermanbill
At least i don’t threaten people for money amirite
Pax1l 22-Sep-22 10:47 AM
Thia is a lie
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Netizenne
Even if Christianity was only adopted and spread by Rome to help increase cohesion amoung its many newly conquered tribes we still co-evolved with it
veganpermanently 22-Sep-22 10:48 AM
it was adopted because it was cheap
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Auwii 22-Sep-22 10:48 AM
Tamest nootropics community members
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veganpermanently 22-Sep-22 10:48 AM
no other religion is going to forgive your sins just because Jesus died on a cross
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veganpermanently
it was adopted because it was cheap
Netizenne 22-Sep-22 10:49 AM
It promoted forming ingroups over doctrine rather than race like the ancestry worshipping pagans of past
10:49
All men made equal by god
10:49
A belief modern empires continue to use for conquering
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Netizenne
It promoted forming ingroups over doctrine rather than race like the ancestry worshipping pagans of past
veganpermanently 22-Sep-22 10:49 AM
see Zoroastrians had the same thing
10:50
Christianity brought no novelty except for cheap redemption
10:50
why do you think christians fanatically preach about Jesus
10:51
because they're promised eternal hedonism if they believe in the concept
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Netizenne 22-Sep-22 10:51 AM
Christianity was about group cohesion imo
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Netizenne
Christianity was about group cohesion imo
veganpermanently 22-Sep-22 10:51 AM
that's what every religion does
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Cast 22-Sep-22 10:51 AM
Christinity is a great cope
10:51
I wish i was under it
10:51
Might join a cult ngl
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Netizenne 22-Sep-22 10:52 AM
Gottta go to claassss byeeeee
10:52
Don’t let chat become a train wreck while inn gone!!!!!! Promote forgiveness!!!!
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Cast
Might join a cult ngl
veganpermanently 22-Sep-22 10:52 AM
Zoroastrianism is still alive btw
10:53
it's a cool religion
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Auwii 22-Sep-22 10:53 AM
Modern religion is current economics science
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MEE6 BOT 22-Sep-22 10:53 AM
@Auwii, you have advanced to lvl 3 respect++ emoji_51
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veganpermanently
Zoroastrianism is still alive btw
Cast 22-Sep-22 10:54 AM
Ive seen some stuff on it. Looks interesting
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veganpermanently
that's what every religion does
Netizenne 22-Sep-22 10:56 AM
Each in their own ways tho Eastern philosophies seem to promote group cohesion by preventing passivity and ever doing anything that would require forgiveness to begin with But I could be wrong
10:56
We co-evolved with different religions
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Cast 22-Sep-22 11:58 AM
Image attachment
11:58
I think mania is coming soon lads
11:58
Hype!
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Netizenne 22-Sep-22 12:18 PM
I feel sick
12:18
Ill to the bone
12:18
Quacking like a mess
12:19
Shaking as if cold
12:21
I must have taken too much caffeine or something
12:21
Or maybe it’s for my lab today
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Cast 22-Sep-22 12:23 PM
https://www.instagram.com/reel/CiuHrxLIVg9/?igshid=MTA0ZTI1NzA=
12:23
Its fuckin comin
12:23
Ill be immune to social pressures
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ibtisam.midlet 22-Sep-22 12:26 PM
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Cast
Click to see attachment 🖼️
veganpermanently 22-Sep-22 12:33 PM
madafaka that t shirt is ugli
12:36
why the fuck is an unknown person constantly sending me videos in whatsapp
12:36
this lasts for MONTHS
12:36
like once a week or so
12:36
so creepy
12:36
no text nothing just videos
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Cast 22-Sep-22 12:40 PM
Lol post
12:40
Lets track him down
12:42
https://www.instagram.com/reel/CiklSrsAmVO/?igshid=MTA0ZTI1NzA=
12:42
Gad damn im so fuckin hyped for ashwaganda
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Cast
Check this out nigger
blank 22-Sep-22 12:46 PM
🧐
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Cast 22-Sep-22 12:47 PM
Image attachment
12:47
The ashwagandha pill is spreading
12:47
Social media hive mind conformation
12:47
So many men are reaching the same conclusion
12:47
To destroy ones emotions
12:47
To become a stress free working machine
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Netizenne 22-Sep-22 12:48 PM
Must have been on TikTok or something ya?
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Cast 22-Sep-22 12:48 PM
Yea
12:48
Its no coincidence that all these things are happening
12:48
If u use social media ur part of the hive mind
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Netizenne 22-Sep-22 12:48 PM
How is ginkgo for stress? Can I just take more of it?
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Cast 22-Sep-22 12:49 PM
We are all living statistically similar lives lol
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Auwii 22-Sep-22 12:49 PM
TikTok is cancer to society, but unfortunately it is driving more and more of current trends (edited)
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Netizenne
How is ginkgo for stress? Can I just take more of it?
Cast 22-Sep-22 12:49 PM
Jusr get ashwaandha
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veganpermanently 22-Sep-22 12:49 PM
ERECTILE DYSFUNCTION
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Netizenne 22-Sep-22 12:49 PM
I’ve started to see everything through life history lens
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veganpermanently 22-Sep-22 12:49 PM
5HT1A agonist ain't nothing new
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veganpermanently
ERECTILE DYSFUNCTION
Cast 22-Sep-22 12:49 PM
Only downside
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veganpermanently 22-Sep-22 12:49 PM
it's just accessible
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Cast
Only downside
veganpermanently 22-Sep-22 12:50 PM
it's not really a downside
12:50
it's a debilitating lifelong condition
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veganpermanently
5HT1A agonist ain't nothing new
Netizenne 22-Sep-22 12:50 PM
Lol is that just how ashwanaganda works?
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ibtisam.midlet 22-Sep-22 12:50 PM
Found out pesuephedrine is not tolerances when you have restless leg syndrome
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Cast 22-Sep-22 12:50 PM
That sucks bro
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ibtisam.midlet
Found out pesuephedrine is not tolerances when you have restless leg syndrome
veganpermanently 22-Sep-22 12:51 PM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546535/
Ephedrine Decreases Vesicular Monoamine Transporter-2 Function
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Cast 22-Sep-22 12:51 PM
Nac and kanna should be just as effective?
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Cast
Nac and kanna should be just as effective?
veganpermanently 22-Sep-22 12:51 PM
Kanna will produce the same side effect but IME it's reversible
12:51
and it's kinda worth it anyways
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Netizenne
How is ginkgo for stress? Can I just take more of it?
Auwii 22-Sep-22 12:51 PM
I have used it extensively Time moves way faster with it. Less stress. You can sometimes take 240mg dose, for few days even, but eventually that will cause side effects But taking 120 mg multiple times a day works perfect It needs to build up first tho (edited)
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veganpermanently
and it's kinda worth it anyways
Cast 22-Sep-22 12:52 PM
Hell yea
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Auwii
I have used it extensively Time moves way faster with it. Less stress. You can sometimes take 240mg dose, for few days even, but eventually that will cause side effects But taking 120 mg multiple times a day works perfect It needs to build up first tho (edited)
Netizenne 22-Sep-22 12:52 PM
Stuff is so busy rn I need more time lol
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veganpermanently
Kanna will produce the same side effect but IME it's reversible
Doctor Bonk 22-Sep-22 12:52 PM
what’s the best Kanna source?
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Cast
Hell yea
veganpermanently 22-Sep-22 12:52 PM
one time I was tied up by a baddy with a limp dick
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veganpermanently
Kanna will produce the same side effect but IME it's reversible
Cast 22-Sep-22 12:52 PM
Lets say ashwaganda is a 5 at emotional blunting. How would you rate kanna and NAC?
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veganpermanently
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546535/
ibtisam.midlet 22-Sep-22 12:53 PM
How to make things works then why things willn't work
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veganpermanently 22-Sep-22 12:53 PM
I told her to untie me and we had a cuddle sesh
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ibtisam.midlet 22-Sep-22 12:53 PM
Any Better
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veganpermanently
one time I was tied up by a baddy with a limp dick
Cast 22-Sep-22 12:53 PM
Dawg wtf
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veganpermanently
one time I was tied up by a baddy with a limp dick
Pax1l 22-Sep-22 12:53 PM
🤨
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ibtisam.midlet 22-Sep-22 12:53 PM
Pleassee
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veganpermanently 22-Sep-22 12:53 PM
next day stuff was working again and I punished her for it
🤨 3
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Netizenne
Stuff is so busy rn I need more time lol
Auwii 22-Sep-22 12:53 PM
Lool, it helps to focus if you are working on something(ability to keep working on something for hours and hours), but also can make you procrastinate more I feel, if you are not working on something you need to do So double edged sword
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Cast 22-Sep-22 12:54 PM
Sus
12:54
I thought u were mgtow
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Auwii
I have used it extensively Time moves way faster with it. Less stress. You can sometimes take 240mg dose, for few days even, but eventually that will cause side effects But taking 120 mg multiple times a day works perfect It needs to build up first tho (edited)
ibtisam.midlet 22-Sep-22 12:55 PM
Works day par day?
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Cast
Lets say ashwaganda is a 5 at emotional blunting. How would you rate kanna and NAC?
veganpermanently 22-Sep-22 12:55 PM
never tried ash. kanna at high dose for a month is 10/10, NAC 7/10 at high dose
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Cast
I thought u were mgtow
veganpermanently 22-Sep-22 12:55 PM
back then I wasn't
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ibtisam.midlet 22-Sep-22 12:55 PM
Primary moa
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ibtisam.midlet
Works day par day?
Auwii 22-Sep-22 12:56 PM
Wdym
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ibtisam.midlet 22-Sep-22 12:56 PM
I want interested in ash BC I'm tolerances to all proteins it interact with
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Auwii
Wdym
ibtisam.midlet 22-Sep-22 12:56 PM
Can you take it everyday and get thershould noticeable effect
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veganpermanently
back then I wasn't
Pax1l 22-Sep-22 12:56 PM
Is it the best philosophy to view relationships with women so obtusely?
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Pax1l
Is it the best philosophy to view relationships with women so obtusely?
veganpermanently 22-Sep-22 12:57 PM
bruh wut
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veganpermanently
never tried ash. kanna at high dose for a month is 10/10, NAC 7/10 at high dose
Cast 22-Sep-22 12:57 PM
Oh shit
12:57
Im goin god mode soon
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veganpermanently 22-Sep-22 12:57 PM
u don't know how I view relationships I never spoke to you about this
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Cast 22-Sep-22 12:58 PM
No emotions + drive
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veganpermanently
u don't know how I view relationships I never spoke to you about this
Pax1l 22-Sep-22 12:58 PM
You mention youre a mgtow
12:58
And you shared a video featuring screamo yesterday
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Pax1l
You mention youre a mgtow
veganpermanently 22-Sep-22 12:58 PM
yeah you can't just assign whatever you know about other monks because I am one
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Pax1l
And you shared a video featuring screamo yesterday
veganpermanently 22-Sep-22 12:59 PM
that was a joke
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veganpermanently
yeah you can't just assign whatever you know about other monks because I am one
Pax1l 22-Sep-22 12:59 PM
Ok epictetus
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veganpermanently 22-Sep-22 12:59 PM
also I prefer monk
12:59
people get wrong ideas
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ibtisam.midlet
Can you take it everyday and get thershould noticeable effect
Auwii 22-Sep-22 01:00 PM
Well, if you take anything everyday eventually that becomes baseline and you don't notice it, not to mention that part of effect is from build up that takes a while to clear. But yeah I think so. I have been taking 120 mg dose for over 6 months, sometimes taking 240 mg
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veganpermanently 22-Sep-22 01:01 PM
monk is more accurate, I'm doing so for a higher cause not for myself only and I'm pretty religious about it anyways
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Auwii
Well, if you take anything everyday eventually that becomes baseline and you don't notice it, not to mention that part of effect is from build up that takes a while to clear. But yeah I think so. I have been taking 120 mg dose for over 6 months, sometimes taking 240 mg
ibtisam.midlet 22-Sep-22 01:01 PM
You can't feel it because lost novelty but it still effect your behaviors in insane way Its called novelty learning a type of tolerance a equal to 30% in drugs and 80% in natural reward's
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Auwii 22-Sep-22 01:02 PM
Hmmm, I see, that's good word to describe it
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ibtisam.midlet
You can't feel it because lost novelty but it still effect your behaviors in insane way Its called novelty learning a type of tolerance a equal to 30% in drugs and 80% in natural reward's
veganpermanently 22-Sep-22 01:02 PM
we also call it honeymoon effect
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Cast 22-Sep-22 01:03 PM
@Doctor Bonk u were on the psychopath pill way before me werent you
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veganpermanently 22-Sep-22 01:03 PM
@Netizenne yo did u try gingko + black seed
13:03
that's like really thin blood
13:04
it drips like water
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Cast 22-Sep-22 01:05 PM
So nac would be acute emotional blunting? @veganpermanently
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Cast
So nac would be acute emotional blunting? @veganpermanently
veganpermanently 22-Sep-22 01:05 PM
yes
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Cast
@Doctor Bonk u were on the psychopath pill way before me werent you
Pax1l 22-Sep-22 01:05 PM
I think many of us are pretty blackpilled on it
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Cast 22-Sep-22 01:07 PM
Im hyped
13:07
Fuck therapy i wont even have emotions soon
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Netizenne 22-Sep-22 01:08 PM
Emotions are good for keeping you from losing all your friends And friends are good for telling you cool and interesting things that can give you insights on life
💟 1
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Cast 22-Sep-22 01:08 PM
Friends are something i wont have for much longer lol
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Netizenne 22-Sep-22 01:09 PM
I guess emotions can also lead to losing all your friends too tho .. (edited)
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veganpermanently 22-Sep-22 01:09 PM
I thought I'll break all bridges with friends and I'll just be solodolo
13:09
so now this motherfucker keeps hitting me up
13:09
some new guy
13:10
which is kinda cool
13:10
vacant spaces are sensed by people
13:10
gotta keep your life as clean as possible to allow for the most growth
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Cast 22-Sep-22 01:11 PM
How will motivation work post kanna?
13:11
Since i wont have much emotions
13:11
Will anything make me ask that girl out or lift weights?
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Cast
Since i wont have much emotions
veganpermanently 22-Sep-22 01:11 PM
I just did things because I knew I had to
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veganpermanently
gotta keep your life as clean as possible to allow for the most growth
Netizenne 22-Sep-22 01:11 PM
Very true Great death tends to be followed by diversification and regrowth
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veganpermanently
I just did things because I knew I had to
Cast 22-Sep-22 01:12 PM
Any pleasure drives?
13:12
Psychopaths seem highly motivated and idk if this will be akin to that or its own thing
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Netizenne
Very true Great death tends to be followed by diversification and regrowth
veganpermanently 22-Sep-22 01:12 PM
no this is not deathist feelisophy
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Netizenne 22-Sep-22 01:12 PM
The social defeat arc can be very psychedelic in that death of old ways can lead to rebirth and restructuring (edited)
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Cast
Any pleasure drives?
veganpermanently 22-Sep-22 01:13 PM
there was a problem with anhedonia for a long time after but I can't tell if that's from the treatment or life circumstances
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Netizenne 22-Sep-22 01:13 PM
Transitional, liminal spaces between when the old ways have died and the new have yet to take root have funny atmospheres to them
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veganpermanently 22-Sep-22 01:13 PM
eventually turned into full blown crippling depression
13:14
then I had a NDE and snapped out of it
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Cast 22-Sep-22 01:14 PM
Oh wtf
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veganpermanently 22-Sep-22 01:15 PM
I can't tell you bro
13:15
I'm not sure
13:15
I never repeated this process
13:15
but I will eventually
13:16
tho I need a bunch of stuff for it
13:16
so much fucking kanna
13:16
lots of harmala, dmt, psilocin
13:17
I did completely change my outlook after the whole cycle including the depression
13:22
I was dependent on external validation before that, required no validation during the process and over time learned to validate myself
13:23
required no validation could be taken with a grain of salt... I did work and everything for a long time but eventually got burned out
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veganpermanently
required no validation could be taken with a grain of salt... I did work and everything for a long time but eventually got burned out
Cast 22-Sep-22 01:30 PM
Yea i dont think this shit will induce psychopathy although stress relief
13:30
Stacking a stimulant on top will probably
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Cast
Stacking a stimulant on top will probably
veganpermanently 22-Sep-22 01:31 PM
do not stack other serotonergics
13:31
especially cocaine
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Cast 22-Sep-22 01:31 PM
Alr ill just use ritalin or addy
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Cast
Alr ill just use ritalin or addy
veganpermanently 22-Sep-22 01:36 PM
still keep cypro around
13:37
that will also reverse the ED quickly
13:37
but mostly because of SS
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veganpermanently
still keep cypro around
Cast 22-Sep-22 01:38 PM
Alr
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Cast 22-Sep-22 01:54 PM
@veganpermanently were you more manipulative post kanna?
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Cast
@veganpermanently were you more manipulative post kanna?
veganpermanently 22-Sep-22 01:56 PM
yeah
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veganpermanently
yeah
Cast 22-Sep-22 01:57 PM
So you can say it also killed your emotional empathy
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Cast
So you can say it also killed your emotional empathy
veganpermanently 22-Sep-22 01:57 PM
obliterated it
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Cast 22-Sep-22 02:00 PM
Impressive
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Pax1l 22-Sep-22 03:10 PM
Do you think that its maladaptive past a certain point to say that is a good thing?
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Cast
@Doctor Bonk u were on the psychopath pill way before me werent you
Doctor Bonk 22-Sep-22 03:19 PM
nah I’ve always been monkpilled, but my reward system allows for pleasure from dysphoria which I seek occasionally
15:21
in other words I can be sadistic in some non-clinical ways 💀
15:21
it’s far from anything psychopathic tho
15:22
it’s closer to the comfort of depression or mental illness
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Cast 22-Sep-22 03:47 PM
Fkkk
15:47
Yo im so damn divided
15:48
Im literally the most divided man on the planet (edited)
15:50
I have like two contradictory traits for every catergory its crazy
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Pax1l 22-Sep-22 03:50 PM
Is your major in stimulants, ephedrine, or meth
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Cast 22-Sep-22 03:50 PM
No i wish
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Cast
No i wish
Pax1l 22-Sep-22 04:10 PM
Youre probably better well off than most people your age. You owe it to yourself to find the root of your problems. My brother in law was a meth major and got stim psychosis
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Pax1l 22-Sep-22 04:17 PM
I used to self report on a semi frequent basis but what can you see is the next step for you getting a better form of happiness
16:20
Noots arent even focused currently on us developing some form of conscientiousness the discussion is often based on inducing psychopathy.
16:21
I recognize its good to be resilient but theres self actualization that comes after that
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MEE6 BOT 22-Sep-22 04:21 PM
@Pax1l, you have advanced to lvl 10 respect++ emoji_51
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macross89 22-Sep-22 05:21 PM
Man
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veganpermanently
obliterated it
Yana 22-Sep-22 06:47 PM
MOA?
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Cast
Click to see attachment 🖼️
Yana 22-Sep-22 09:13 PM
"In the future, everyone wil be famous for 15 minutes" - not Andy Warhol
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Yana
"In the future, everyone wil be famous for 15 minutes" - not Andy Warhol
Pax1l 22-Sep-22 09:30 PM
kek Cast is singlehandedly raising the standard of living of the one ashwagandha farmer in some far off land
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Yana
MOA?
veganpermanently 23-Sep-22 12:00 AM
I would guess extreme serotonergic desensitization, oxytocin release downregulation or else.
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Netizenne 23-Sep-22 12:20 AM
My demoxytocin and pig brains arrived
00:20
mildronate too
00:20
I ate an oxytocin 5 min ago
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Netizenne
I ate an oxytocin 5 min ago
veganpermanently 23-Sep-22 12:21 AM
dem is orally available?
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Netizenne
mildronate too
veganpermanently 23-Sep-22 12:22 AM
https://pubmed.ncbi.nlm.nih.gov/32389661/
Long-term mildronate treatment increased Proteobacteria level in gu...
Mildronate is a cardiac and neuroprotective drug that is widely used in some countries. By inhibiting carnitine biosynthesis, mildronate impairs the fatty acids transport into mitochondria, thereby decreasing the β-oxidation intensity. Since 2016, it has been prohibited by the World Anti-Doping Agen …
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veganpermanently
dem is orally available?
Netizenne 23-Sep-22 12:23 AM
Ya I let it sit under my tongue dissolved for a while anyways
00:24
I feel like it’s gonna be mild so I’m wondering if I should take a megadose, part of why I’m taking it is to see how subjectively feels
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veganpermanently 23-Sep-22 12:24 AM
don't take mildro continually
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veganpermanently
https://pubmed.ncbi.nlm.nih.gov/32389661/
Netizenne 23-Sep-22 12:25 AM
Waaaa despair
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veganpermanently 23-Sep-22 12:26 AM
yeah I guess IV infusion would be best
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Netizenne 23-Sep-22 12:26 AM
I wonder if I should snort a pill of demoxy
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veganpermanently 23-Sep-22 12:27 AM
don't snort pills
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Netizenne 23-Sep-22 12:27 AM
there’s probably fillers
00:27
But if it’s just the once is it really that harmful?
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veganpermanently 23-Sep-22 12:27 AM
would u snort crushed sand?
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Netizenne 23-Sep-22 12:27 AM
maybe I should dissolve it
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Netizenne
I wonder if I should snort a pill of demoxy
ibtisam.midlet 23-Sep-22 01:44 AM
I snort them no problem
01:46
Between vit b 6 is toxic in overdose
01:46
The margine is not high really
01:47
I would do that with pure Doxylamine
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ibtisam.midlet
Between vit b 6 is toxic in overdose
veganpermanently 23-Sep-22 01:47 AM
yeah pyridoxamine
01:47
not P5P
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ibtisam.midlet 23-Sep-22 01:56 AM
I took 3 grams vit b1/6 and get mild social disinhibition
01:58
I think megadosing sulbutiamine will give potent effect it act like a drug works even if you don't have deficiency
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veganpermanently 23-Sep-22 01:58 AM
big difference between phosphorylated B6 and not
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ibtisam.midlet
I think megadosing sulbutiamine will give potent effect it act like a drug works even if you don't have deficiency
veganpermanently 23-Sep-22 01:59 AM
I think same could be said for any modified water soluble vitamin that's made to be lipophillic
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ibtisam.midlet 23-Sep-22 01:59 AM
demoxytocin with it boom
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veganpermanently 23-Sep-22 01:59 AM
ascorbyl palmitate
👍 1
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ibtisam.midlet 23-Sep-22 02:00 AM
Bey bey asburger
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veganpermanently
I think same could be said for any modified water soluble vitamin that's made to be lipophillic
ibtisam.midlet 23-Sep-22 02:01 AM
mmmh yes
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ibtisam.midlet
mmmh yes
veganpermanently 23-Sep-22 02:01 AM
we should look for other
02:03
attaching an adamantane group to any very small chemical with poor pharmacokinetics improves it immensely
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ibtisam.midlet 23-Sep-22 02:03 AM
How much it cost to get those stuff
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veganpermanently 23-Sep-22 02:04 AM
Pyridoxine Tris- Hexyldecanoate
02:04
example
02:04
tho we would need to phosphorylate it
02:05
consuming this IN would cause parkinson like symptoms quickly and probably irreversibly
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ibtisam.midlet 23-Sep-22 02:05 AM
I would need to learn some chemistry
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veganpermanently
Pyridoxine Tris- Hexyldecanoate
veganpermanently 23-Sep-22 02:06 AM
looks too big tho
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Yana
"In the future, everyone wil be famous for 15 minutes" - not Andy Warhol
JK 23-Sep-22 02:07 AM
And nobody will drop the bass..
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veganpermanently 23-Sep-22 02:56 AM
Just realized my scale was set to oz not g which means I took a triple amount of everything since this happened which is I dunno when. I've been having palpitations, fast heartbeats out of nowhere, heard heartbeat at the back of my neck, presumably because I dosed around 600 mg of Ginkgo daily because when I reduced the dose to 100 mg /actually 300/ it stopped.
02:57
also no wonder my joints don't hurt anymore, I've been taking 6000 mg of MSM daily
02:58
fucken pounded leucine yesterday, 21 g supplemental, 18 g citrulline malate
02:58
roflmao
emoji_1 3
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Potential 23-Sep-22 05:01 AM
@veganpermanently Well at least you're still alive.
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Cast 23-Sep-22 06:48 AM
Bruh im crippled
06:49
Ive had brutal anxiety for two days straight im fuckin waiting for my ashwagandha to savd my ass
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Cast 23-Sep-22 07:26 AM
Great my mother started opening my packages
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Cast
Great my mother started opening my packages
ibtisam.midlet 23-Sep-22 07:31 AM
what happen
07:33
take some of what there when she opening the package
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Cast 23-Sep-22 07:33 AM
Alr
07:34
Im gonna take some ash is the anxiety eleviation acute?
07:34
Ive had anxiety since i got up
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ibtisam.midlet 23-Sep-22 07:34 AM
whats the type of anxiety
07:34
you have
07:38
cortisol study always being accurate matric for efficacy of anxiolytic as cortisol being direct biomarker of it
07:38
you can compare it something like benzo
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ibtisam.midlet
whats the type of anxiety
Cast 23-Sep-22 07:38 AM
Acute anxiety
07:38
From the nightmares lol
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Cast
From the nightmares lol
ibtisam.midlet 23-Sep-22 07:39 AM
dreams?
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ibtisam.midlet
dreams?
Cast 23-Sep-22 07:40 AM
Yes
07:40
And i got left on read by a girl i like
07:43
Basically it all starting spiraling down
07:43
And now in the aftermath i got bad anxiety
07:45
Wtf
07:46
Its suppose to take weeks
07:46
To kick in
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ibtisam.midlet 23-Sep-22 07:46 AM
https://www.absoluteability.com/dating/what-to-do-when-a-girl-leaves-you-on-read/
What To Do When a Girl Leaves You on Read • Absolute Ability
This article helps you know what to do when a girl leaves you on read. Hint... it's not send a long series of desperate messages.
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07:46
Here’s what not to do when a girl leaves you on read Do NOT go buy an AR-15, hit the mall and go on GTA style killing spree. Do NOT make purple drank and get so pissed you can’t remember your own name. Do NOT sign up for a military deployment in the Middle East
💀 2
07:47
And definitely do NOT send her a whole bunch of needy, weird, psychotic, overly emotional messages begging, pleading, or shaming her into returning your messages. Because that never works, and I’ll explain why.
07:47
read farther baby
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Cast 23-Sep-22 07:48 AM
I didnt dm her again
07:50
I thought it was okay to dm her because i already knew her and she already showed interest in me
07:51
But
07:51
I should have just waited to see her in person again
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ibtisam.midlet 23-Sep-22 07:51 AM
just buy a girl friend that's it
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Cast 23-Sep-22 07:52 AM
My nac should come today
07:52
That should eleviate my anxiety
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ibtisam.midlet 23-Sep-22 07:53 AM
you need emotion blunting anti anxiety type
07:55
which ashwagandha works for
07:55
also nmda antagonist like agematine and magnesium pidolate
07:56
nac also
07:56
but i blunt alot of thing other then taht
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ibtisam.midlet
you need emotion blunting anti anxiety type
Cast 23-Sep-22 07:56 AM
Yea this should help me
07:56
Ive been real fucked up this summer
07:56
From two major events and i guess this one too
07:56
But its a buildup
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ibtisam.midlet 23-Sep-22 07:56 AM
hope you get better ♥
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Cast 23-Sep-22 07:57 AM
My neuroticism has gone up substantially and is now my most prominent trait
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ibtisam.midlet 23-Sep-22 07:57 AM
lamotrigin also works
07:58
benzo is not good for this
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ibtisam.midlet
lamotrigin also works
Cast 23-Sep-22 07:59 AM
The mix i got has 5mg of black pepper seed exreact per capsule
08:00
Is this to make up for the lack of acute effects?
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ibtisam.midlet 23-Sep-22 08:00 AM
it increase bioavailability
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ibtisam.midlet
it increase bioavailability
Cast 23-Sep-22 08:00 AM
Oh i see
08:01
Ok i just took a dose
08:01
Does it do anything day 1? @ibtisam.midlet
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ibtisam.midlet 23-Sep-22 08:02 AM
substance always works from day one
08:02
if it not
08:02
then you can megadose
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ibtisam.midlet
substance always works from day one
Cast 23-Sep-22 08:02 AM
How much is a megadose?
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ibtisam.midlet 23-Sep-22 08:02 AM
otherwise will not have veganpramanentyl here
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Cast
How much is a megadose?
ibtisam.midlet 23-Sep-22 08:03 AM
what you will megadose first
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ibtisam.midlet
what you will megadose first
Cast 23-Sep-22 08:03 AM
Ashwagandha
08:03
I dont have nac yet
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ibtisam.midlet 23-Sep-22 08:05 AM
see half life and take a dose every interval of it
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ibtisam.midlet
see half life and take a dose every interval of it
Cast 23-Sep-22 08:06 AM
I read that it only works long term
08:06
Like weeks of daily dosing
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ibtisam.midlet 23-Sep-22 08:07 AM
Ashwagandha has a half-life of around five to six hours
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Cast
Like weeks of daily dosing
ibtisam.midlet 23-Sep-22 08:07 AM
doctor detected
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ibtisam.midlet
doctor detected
Cast 23-Sep-22 08:09 AM
Every source is saying 2 weeks to a month for anxiety relief
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ibtisam.midlet 23-Sep-22 08:10 AM
darknet is 99% of internet
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ibtisam.midlet
darknet is 99% of internet
Cast 23-Sep-22 08:11 AM
Yea what about it?
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Netizenne
mildronate too
Yana 23-Sep-22 08:22 AM
Based
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Cast 23-Sep-22 08:22 AM
Jesus
08:22
All i had to do was not dm her
08:23
And this slippery slope wouldnt have happened
08:23
Then wait until monday to see her again irl
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Netizenne
I ate an oxytocin 5 min ago
ibtisam.midlet 23-Sep-22 08:23 AM
Snorting
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veganpermanently
don't take mildro continually
Yana 23-Sep-22 08:24 AM
I reckon ethyl pyruvate is safer alternative (edited)
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ibtisam.midlet
Snorting
ibtisam.midlet 23-Sep-22 08:24 AM
Its only works by that
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Yana 23-Sep-22 08:25 AM
Pyrucet is pretty cool
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Cast
Like weeks of daily dosing
blank 23-Sep-22 08:29 AM
that's for the supposed testosterone benefits but the anxiolysis is acute
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blank
that's for the supposed testosterone benefits but the anxiolysis is acute
Cast 23-Sep-22 08:30 AM
Sources have been telling me its long term but i already feel less anxious so ill take your word for it
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blank
that's for the supposed testosterone benefits but the anxiolysis is acute
Cast 23-Sep-22 08:31 AM
Ask sirsad to let me back into nootopics in 2 weeks since ill be mentally stable (edited)
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Cast
Ask sirsad to let me back into nootopics in 2 weeks since ill be mentally stable (edited)
blank 23-Sep-22 08:31 AM
it's not happening for a while but good luck
08:31
Sticker
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Cast 23-Sep-22 09:00 AM
Yea im lowkey not anxious much rn
👍 1
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Yana
Based
Netizenne 23-Sep-22 10:10 AM
For biking about longer!
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ibtisam.midlet
Its only works by that
Netizenne 23-Sep-22 10:10 AM
Meant demoxytocin
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veganpermanently
https://pubmed.ncbi.nlm.nih.gov/32389661/
Yana 23-Sep-22 10:47 AM
Why is the brain so different?? It's like it just flipped the switch instead of further favoring glucose oxidation
Image attachment
10:49
A lot of complexity idk about its MOA wrt. carnitine and stuff so maybe it just requires even more buildup for PPAR-A to go down unless it has some kind of inverse relationship with PGC-1α or something
10:49
And maybe the dear rodents were hungry for carbs. They didn't say what the feed was
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Netizenne 23-Sep-22 11:44 AM
Are there studies on how endurance training effects these genes to compare to.?? (edited)
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Yana
Why is the brain so different?? It's like it just flipped the switch instead of further favoring glucose oxidation
ibtisam.midlet 23-Sep-22 11:55 AM
??
11:59
https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.14926
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Yana
I reckon ethyl pyruvate is safer alternative (edited)
veganpermanently 23-Sep-22 12:39 PM
Thanks but I don't see the connection
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Yana
Why is the brain so different?? It's like it just flipped the switch instead of further favoring glucose oxidation
veganpermanently 23-Sep-22 12:39 PM
It's not that the brain is different than the gut, it's that we're a completely different lifeform than the bacteria that live in our gut
12:40
tho' the effects on the heart might not be caused by the dysbiosis
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Yana
And maybe the dear rodents were hungry for carbs. They didn't say what the feed was
veganpermanently 23-Sep-22 12:42 PM
High fat would be mentioned or at least I hope so. If scientists can get away with not mentioning they feed high fat we can throw all of the fear mongering studies in the trash
emoji_52 1
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veganpermanently
Thanks but I don't see the connection
Yana 23-Sep-22 12:45 PM
Potent FAO inhibitor, stimulating PDH, and so on
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Yana
Potent FAO inhibitor, stimulating PDH, and so on
veganpermanently 23-Sep-22 12:46 PM
do you know the underlying moa
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veganpermanently
do you know the underlying moa
Yana 23-Sep-22 12:47 PM
Being pyruvate is a place to start
12:47
Lol
12:47
https://raypeatforum.com/community/threads/pyrucet-liquid-ethyl-pyruvate-aceatoacetate-mix.27487/ This has 999 references
Pyrucet - Liquid (ethyl) Pyruvate/Aceatoacetate Mix
As many forum users know, I have been interested in the Randle Cycle (glucose/fat competition for oxidation) for quite some time. The topic of limiting fatty acid oxidation (FAO) and promoting glucose oxidation is pretty central to the metabolic theory of health. Peat has written many times on...
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veganpermanently
It's not that the brain is different than the gut, it's that we're a completely different lifeform than the bacteria that live in our gut
Yana 23-Sep-22 12:53 PM
Yeah true I just wanna know why PPAR-A was raised in the brain when it's mildronate; is its whole pharmacology dependent on interactions with the microbiome?
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Cast 23-Sep-22 12:55 PM
@veganpermanently ashwagandha hittin good
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Yana
https://raypeatforum.com/community/threads/pyrucet-liquid-ethyl-pyruvate-aceatoacetate-mix.27487/ This has 999 references
veganpermanently 23-Sep-22 01:00 PM
thanks. that forum is a gold mine but I avoid it for obvious reasons. should maybe visit it from time to time
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Yana
Yeah true I just wanna know why PPAR-A was raised in the brain when it's mildronate; is its whole pharmacology dependent on interactions with the microbiome?
veganpermanently 23-Sep-22 01:01 PM
no it's pharmacology is due to the inhibition of carnitine synthesis
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Cast
@veganpermanently ashwagandha hittin good
veganpermanently 23-Sep-22 01:01 PM
hit back
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veganpermanently
hit back
Cast 23-Sep-22 01:03 PM
Stabilized my mood nicely just took another dose
13:04
Been thinking alot about society ya know
13:04
Wondering if we are in a dystopia
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veganpermanently 23-Sep-22 01:04 PM
nah
13:04
this is
13:04
https://www.youtube.com/watch?v=N9XKLqGqwLA
Grimes
Grimes - REALiTi
13:07
grimes is a prime example of the wall
13:08
she was so beautiful, so approachable in 2015 still
13:08
post wall
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Cast
Wondering if we are in a dystopia
Yana 23-Sep-22 01:09 PM
Is this the ashwagandha mindset
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veganpermanently 23-Sep-22 01:09 PM
Image attachment
13:09
gremlins
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Yana
Is this the ashwagandha mindset
Cast 23-Sep-22 01:09 PM
No
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veganpermanently
Click to see attachment 🖼️
Cast 23-Sep-22 01:09 PM
U got a celeb crush dont ya
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Yana 23-Sep-22 01:09 PM
Sour grapes you just wish you were elon musk bro
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Cast
U got a celeb crush dont ya
veganpermanently 23-Sep-22 01:10 PM
I'm in love with yung Grimes
13:10
she doesn't exist tho
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Cast
No
Cast 23-Sep-22 01:10 PM
Its because i watched black mirror episode 1 season 3 (edited)
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veganpermanently 23-Sep-22 01:10 PM
that's why cloning people should be a thing
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Cast 23-Sep-22 01:10 PM
Lol
13:10
Bruh
13:11
Image attachment
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veganpermanently 23-Sep-22 01:11 PM
dude I even found a girl that looks like her (edited)
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Cast 23-Sep-22 01:11 PM
I was practicing typinf (edited)
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veganpermanently
dude I even found a girl that looks like her (edited)
Cast 23-Sep-22 01:11 PM
Irl?
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Cast
Irl?
veganpermanently 23-Sep-22 01:11 PM
yeah
13:12
had a good run with her but she's too evil
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Cast 23-Sep-22 01:12 PM
You brokeup?
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Cast
You brokeup?
veganpermanently 23-Sep-22 01:12 PM
well I'm not sure who broke up
13:13
tho' she had the last word
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Cast 23-Sep-22 01:13 PM
Rough shit. Been mgtow since? (edited)
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veganpermanently 23-Sep-22 01:13 PM
yea
13:14
I think there was some wrongdoing I'm unaware of
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MEE6 BOT 23-Sep-22 01:14 PM
@veganpermanently, you have advanced to lvl 19 respect++ emoji_51
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veganpermanently 23-Sep-22 01:14 PM
what I do know is that she was in a relationship for 5 yrs and kinda started dating me while she was still in the relationship
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Cast 23-Sep-22 01:15 PM
Bruh
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veganpermanently 23-Sep-22 01:15 PM
gave me chlamydia
975869370045722694 1
13:15
the dude requested an open relationship
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Cast 23-Sep-22 01:16 PM
Thats nasty
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veganpermanently 23-Sep-22 01:16 PM
she knew I was against all that shit and kept it secret until I fucked her
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Cast 23-Sep-22 01:16 PM
Post sex clarity?
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veganpermanently 23-Sep-22 01:16 PM
which I really tried to postpone
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veganpermanently
which I really tried to postpone
Cast 23-Sep-22 01:16 PM
Polyamory is bad news
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Cast
Post sex clarity?
veganpermanently 23-Sep-22 01:17 PM
classical monkey branching shit
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Cast 23-Sep-22 01:17 PM
Makes me wonder if the promiscuous girl im pursuing is still dating the boy she was eager to cheat on
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veganpermanently 23-Sep-22 01:17 PM
made me upset when she told me but decided to keep pursuing bcs I liked her so much
13:18
so I told her she can be exclusive with me or fuck off
13:18
she decided to be exclusive
13:18
... a few weeks later
13:18
puts antibiotics on the table
975869370045722694 1
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Cast 23-Sep-22 01:18 PM
Oh boy
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veganpermanently 23-Sep-22 01:19 PM
I don't think she cheated
13:19
it's also possible I gave her chlamydia
13:19
bcs the ex before her got ovarian cancer a few years later
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Cast 23-Sep-22 01:19 PM
Bro who knows
13:19
I would blame her tbh
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veganpermanently 23-Sep-22 01:19 PM
it's all nasty shit
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Cast 23-Sep-22 01:20 PM
She already wanted an open relationship
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MEE6 BOT 23-Sep-22 01:20 PM
@Cast, you have advanced to lvl 14 respect++ emoji_51
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Cast 23-Sep-22 01:20 PM
Red flag af
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Cast
I would blame her tbh
veganpermanently 23-Sep-22 01:20 PM
my doc literally told me not to blame her
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Cast
She already wanted an open relationship
veganpermanently 23-Sep-22 01:20 PM
no
13:20
the dude she was with wanted an open relationship
13:20
she accepted it tho'
13:20
and decided to pursue me without telling me about it
13:21
that was the red flag
13:21
tho she did break up with the guy before we fucked
13:21
but told me about that shit after we fucked
13:21
which was lousy
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Cast 23-Sep-22 01:21 PM
Why did it all end?
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Cast
Why did it all end?
veganpermanently 23-Sep-22 01:22 PM
bcs I lost trust
13:22
I have trust issues but it's not a problem until someone does me
13:23
esp if it's related to longevity
13:23
I'm fucking immortalist you can't give me an STD and expect me to trust u
13:23
https://www.youtube.com/watch?v=JtH68PJIQLE
GrimesVEVO
Grimes - Oblivion
13:24
u know what's special about this video
13:24
1:43
13:24
yung Matt from Yes Theory
13:24
roflmao
13:25
before yes theory was a thing
13:25
he was on a yes theory video 😮
13:25
stuff like this really makes me think if everything was planned in advanced
13:26
illuminati matrix type conspiracy theories start forming in my head
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Cast 23-Sep-22 01:26 PM
Its the hivemind dude
13:26
Im starting to believe in manifestation
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veganpermanently 23-Sep-22 01:26 PM
grimes might be genius
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Cast
Im starting to believe in manifestation
veganpermanently 23-Sep-22 01:27 PM
me too funnily
13:27
like each day I'm in a good mood almost nothing bad ever happens
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Cast
Im starting to believe in manifestation
veganpermanently 23-Sep-22 01:28 PM
https://www.youtube.com/watch?v=Lk6AkrT5g5w
Thewizardliz
This video will change your life
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veganpermanently
like each day I'm in a good mood almost nothing bad ever happens
Cast 23-Sep-22 01:28 PM
Very true
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Cast
Very true
veganpermanently 23-Sep-22 01:29 PM
correlation doesn't equal causation
13:29
something to consider for all schizotypicals
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Cast
Makes me wonder if the promiscuous girl im pursuing is still dating the boy she was eager to cheat on
Netizenne 23-Sep-22 01:30 PM
The idea of dating people who’ve had many partners before you is kinda spook You know they have a tendency for moving on
13:30
but what do I knw
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Netizenne
The idea of dating people who’ve had many partners before you is kinda spook You know they have a tendency for moving on
veganpermanently 23-Sep-22 01:31 PM
yeah but it's no tell
13:31
most of my gfs had one or none partners before me
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veganpermanently
most of my gfs had one or none partners before me
CEO 23-Sep-22 01:32 PM
My current girlfriend is an ex pornstar
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Netizenne
The idea of dating people who’ve had many partners before you is kinda spook You know they have a tendency for moving on
Cast 23-Sep-22 01:32 PM
I still think i have chance with this girl ngl (edited)
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CEO
My current girlfriend is an ex pornstar
veganpermanently 23-Sep-22 01:32 PM
Mrs. Fleshlight? (edited)
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veganpermanently
Mrs. Fleshlight? (edited)
CEO 23-Sep-22 01:32 PM
Nah thats my side chick
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Cast 23-Sep-22 01:32 PM
I have hidden social game i just need to boost my confidence
13:33
Ashwagandha is working
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veganpermanently
most of my gfs had one or none partners before me
veganpermanently 23-Sep-22 01:33 PM
they all turned sour after me
13:33
that's like a trap song
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Cast 23-Sep-22 01:33 PM
But theres a difference between beinf confident at home and in public
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veganpermanently 23-Sep-22 01:33 PM
just gotta word it right
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Cast
But theres a difference between beinf confident at home and in public
veganpermanently 23-Sep-22 01:34 PM
I have confidence I need to dumb down all the time
13:34
people get scared
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Cast 23-Sep-22 01:34 PM
Lol post kanna?
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Cast
Lol post kanna?
veganpermanently 23-Sep-22 01:34 PM
after my life of ups and downs I guess
13:35
I had so much stuff happen to me people can't relate
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veganpermanently
thanks. that forum is a gold mine but I avoid it for obvious reasons. should maybe visit it from time to time
Netizenne 23-Sep-22 01:35 PM
Wait what obvious reasons
13:35
?
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veganpermanently 23-Sep-22 01:35 PM
I just look at everybody as plebs
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Netizenne
Wait what obvious reasons
veganpermanently 23-Sep-22 01:35 PM
it's ray peat's house
13:35
u don't wanna go there
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Netizenne 23-Sep-22 01:36 PM
Maybe I’ll become a Ray peater!!!!
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Cast
But theres a difference between beinf confident at home and in public
veganpermanently 23-Sep-22 01:36 PM
confidence comes from experience
13:37
the fact that words can hurt you shows you need it desperately
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Cast 23-Sep-22 01:37 PM
I should be gucci now
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veganpermanently 23-Sep-22 01:37 PM
https://www.youtube.com/watch?v=mV98fPNk_qs
Ascended Mindset
CALLUS YOUR MIND | David Goggins Motivation
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Cast 23-Sep-22 01:37 PM
Kanna + ash + nac
13:38
Im gonna approach her again if im still just as confident
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Cast
Kanna + ash + nac
veganpermanently 23-Sep-22 01:38 PM
that WILL give you ED
13:38
maybe PSSD as well
13:38
have cypro ready
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Cast 23-Sep-22 01:38 PM
Oh fuck
13:39
Thats retarded
13:39
Its seems like a really fitting side effect
13:39
Makes u more confident but then makes u impotent lol
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veganpermanently 23-Sep-22 01:39 PM
kanna ED is rare
13:39
I know no one that had it except me
13:40
and I did mix other substances
13:40
most notably high dose nettle extract and mushrooms
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Cast 23-Sep-22 01:40 PM
Damn bro
13:40
What was ur intent
13:40
For taking these subtances
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veganpermanently 23-Sep-22 01:40 PM
self development
13:40
took nettle extract for hairloss
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veganpermanently
self development
Cast 23-Sep-22 01:42 PM
I see
13:42
Before or after ur last gf?
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Cast
Before or after ur last gf?
veganpermanently 23-Sep-22 01:43 PM
that was way before
13:43
had another girl for years in between
13:44
that one spawned in front of my building a few months ago
13:44
after 4 yrs of silence
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Cast 23-Sep-22 01:44 PM
Lol spawned bro
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veganpermanently 23-Sep-22 01:44 PM
fucking bitch
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Cast 23-Sep-22 01:44 PM
I swtg thats accurate
13:44
U believe in manifestation?
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Cast
I swtg thats accurate
veganpermanently 23-Sep-22 01:44 PM
yeah she's like a pretty demon
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Cast
U believe in manifestation?
veganpermanently 23-Sep-22 01:44 PM
I don't believe anything
13:45
I observe uncover question and prove
13:45
I have no proof for that silly shit
13:45
it's fun to entertain
13:45
but who knows
13:46
just like god
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Netizenne
Wait what obvious reasons
Yana 23-Sep-22 01:46 PM
There are many potential reasons but the only obvious one is looking at the front page circa 2022
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veganpermanently 23-Sep-22 01:46 PM
motherfucker my religion is unknown
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Cast 23-Sep-22 01:46 PM
Im starting to think its real
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veganpermanently 23-Sep-22 01:46 PM
if u kill me u might go to heaven you might go to hell
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Cast 23-Sep-22 01:46 PM
I think we are a hive mind
13:47
And the law of attraction works through the shared unconscious
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Cast
And the law of attraction works through the shared unconscious
veganpermanently 23-Sep-22 01:47 PM
prove it
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Cast 23-Sep-22 01:47 PM
It cant be proved
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veganpermanently 23-Sep-22 01:47 PM
did u look at the video I sent u
13:47
that pretty hoe
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Cast 23-Sep-22 01:47 PM
I was watching some i got distracted
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veganpermanently 23-Sep-22 01:48 PM
https://www.youtube.com/watch?v=Lk6AkrT5g5w
Thewizardliz
This video will change your life
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Cast
I was watching some i got distracted
veganpermanently 23-Sep-22 01:48 PM
watch it until the end
13:48
she delivers a method
13:48
didn't try it yet
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veganpermanently
took nettle extract for hairloss
JK 23-Sep-22 01:48 PM
Did it help?
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veganpermanently 23-Sep-22 01:48 PM
but I will
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JK
Did it help?
veganpermanently 23-Sep-22 01:49 PM
yes it reversed the hairloss completely
13:49
and lasted a long time after as well
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veganpermanently
yes it reversed the hairloss completely
JK 23-Sep-22 01:49 PM
damn, i got some was somewhat cautious about using it
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veganpermanently 23-Sep-22 01:49 PM
gave me gyno tho
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JK 23-Sep-22 01:49 PM
ah okay
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Cast 23-Sep-22 01:49 PM
Im suspicous but ill listeb
13:49
I think her lip fillers are giving her a lisp lol
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JK 23-Sep-22 01:50 PM
i can't seem to figure out if DHT causes hairloss or not
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Cast
I think her lip fillers are giving her a lisp lol
veganpermanently 23-Sep-22 01:50 PM
I don't care about her
13:50
her looks, philosophy or any of that
13:50
but the method seems useful
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JK
i can't seem to figure out if DHT causes hairloss or not
Yana 23-Sep-22 01:50 PM
As far as I'm aware this is the current canon
Image attachment
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Yana
As far as I'm aware this is the current canon
veganpermanently 23-Sep-22 01:51 PM
good diagram. yess
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Yana
As far as I'm aware this is the current canon
JK 23-Sep-22 01:51 PM
Perfect
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Cast 23-Sep-22 01:52 PM
Fuck it im willing to try it
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Yana 23-Sep-22 01:52 PM
There's a lot more though
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JK 23-Sep-22 01:52 PM
Do you have an studies u utilized to make it, you could provide as well?
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Cast
Fuck it im willing to try it
veganpermanently 23-Sep-22 01:52 PM
it costs nothing except a few hours of work to make the video
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Yana 23-Sep-22 01:52 PM
Namely low WNT10 signaling
13:52
https://pubmed.ncbi.nlm.nih.gov/32736705/ (edited)
Ectodysplasin-A2 induces dickkopf 1 expression in human balding der...
Androgenetic alopecia (AGA) is a common genetic disorder, and a X-chromosomal locus that contains the androgen receptor (AR) and ectodysplasin A2 receptor (EDA2R) genes represents a major susceptibility locus for AGA. In our previous study, we reported that ectodysplasin-A2 (EDA-A2) induces apoptosi …
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👍 1
13:53
Image attachment
13:54
Dickkopf literally german for dickhead
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JK 23-Sep-22 01:54 PM
lol
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Cast 23-Sep-22 01:55 PM
Shes actually spitting facts ngl
13:55
I thought she was just some dumb bimbo lol
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Cast
I thought she was just some dumb bimbo lol
veganpermanently 23-Sep-22 01:55 PM
actually some of the smartest women on Earth look like her
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Yana 23-Sep-22 01:56 PM
Ectodysplasin A = TNF-19
13:56
I think the androgens are always protective factors but just at great cost aesthetically I guess
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Yana
I think the androgens are always protective factors but just at great cost aesthetically I guess
veganpermanently 23-Sep-22 01:57 PM
who needs hair
13:57
👽
975869370045722694 2
13:57
we have tinfoil hats
13:58
in 2020 I literally decided to loose all my hair
13:58
by slamming BDNFergics and becoming a noot demon
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Cast 23-Sep-22 01:58 PM
Honestly the thing is
13:58
I was fucking manifesting this girl
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Cast
I was fucking manifesting this girl
veganpermanently 23-Sep-22 01:59 PM
remove the manifesting
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Cast 23-Sep-22 01:59 PM
Likr lowkey thinking about how crazy it would be if she came to my college
13:59
And she did
13:59
Now i need to manifest harder lol
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veganpermanently 23-Sep-22 01:59 PM
no you need to remove manifestion
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Netizenne 23-Sep-22 01:59 PM
Baldness is neotenous
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veganpermanently 23-Sep-22 01:59 PM
and you're left with good sex
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Netizenne 23-Sep-22 01:59 PM
Like all the rest of the traits of an alien
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Cast 23-Sep-22 02:00 PM
?
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JK 23-Sep-22 02:00 PM
fr some bald women are good looking
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Netizenne 23-Sep-22 02:00 PM
Neoteny is the ideal path of our evolution
14:00
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veganpermanently 23-Sep-22 02:00 PM
nefertiti bang bang
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JK
fr some bald women are good looking
veganpermanently 23-Sep-22 02:01 PM
Image attachment
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Cast 23-Sep-22 02:01 PM
Alot of this is extremely foreign to me
14:01
As an intp lol
14:01
I like logic alot
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veganpermanently
Click to see attachment 🖼️
JK 23-Sep-22 02:01 PM
U know it!
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MEE6 BOT 23-Sep-22 02:01 PM
@JK, you have advanced to lvl 9 respect++ emoji_51
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Netizenne
Neoteny is the ideal path of our evolution
veganpermanently 23-Sep-22 02:01 PM
my bet is that Emi has manifested you into realiti
Holyshig 2
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Cast
I was fucking manifesting this girl
Netizenne 23-Sep-22 02:01 PM
Imo manifesting stuff it’s just programming the values of your unconscious attention directing process (edited)
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Netizenne
Imo manifesting stuff it’s just programming the values of your unconscious attention directing process (edited)
Cast 23-Sep-22 02:02 PM
I think its deeper than that
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Netizenne
Imo manifesting stuff it’s just programming the values of your unconscious attention directing process (edited)
veganpermanently 23-Sep-22 02:02 PM
nice way to put it
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Cast 23-Sep-22 02:02 PM
Like
14:02
I think theres pathways
14:03
Via law of attraction
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veganpermanently
nice way to put it
JK 23-Sep-22 02:03 PM
Really!
14:03
We should make a thread for that
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Cast 23-Sep-22 02:03 PM
And when u reprogram ur unconscious it will follow certain pathways rhat lead u to other people
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Cast
And when u reprogram ur unconscious it will follow certain pathways rhat lead u to other people
veganpermanently 23-Sep-22 02:03 PM
that's what she said
14:04
emoji_51
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Cast 23-Sep-22 02:04 PM
It is?
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veganpermanently 23-Sep-22 02:04 PM
Wiz Liz the bitch from twitch
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Netizenne 23-Sep-22 02:05 PM
I’ve started to think about engaging my internal unconscious (my brain) the way I do my external unconscious (you guys). If I just talk about what I want enough the unconscious will take interest, latch on, and get to work.
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Cast 23-Sep-22 02:06 PM
Metaphyaics
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Netizenne
I’ve started to think about engaging my internal unconscious (my brain) the way I do my external unconscious (you guys). If I just talk about what I want enough the unconscious will take interest, latch on, and get to work.
Cast 23-Sep-22 02:06 PM
True
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Netizenne
I’ve started to think about engaging my internal unconscious (my brain) the way I do my external unconscious (you guys). If I just talk about what I want enough the unconscious will take interest, latch on, and get to work.
veganpermanently 23-Sep-22 02:07 PM
there is no u guys
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Cast 23-Sep-22 02:07 PM
But i think theres demons
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veganpermanently 23-Sep-22 02:07 PM
there is only cosa nostra
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Cast 23-Sep-22 02:07 PM
Theres demonic energy too
14:07
They torment me frequently
14:07
And they destroy my good plans
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veganpermanently 23-Sep-22 02:08 PM
see people will call you crazy man
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Netizenne
I’ve started to think about engaging my internal unconscious (my brain) the way I do my external unconscious (you guys). If I just talk about what I want enough the unconscious will take interest, latch on, and get to work.
Netizenne 23-Sep-22 02:08 PM
This is how meditate
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veganpermanently 23-Sep-22 02:08 PM
u need to adopt a religion asap
14:08
to hide in the masses
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Cast 23-Sep-22 02:08 PM
Nah
14:08
Im on to some deep shit
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Cast
Theres demonic energy too
Doctor Bonk 23-Sep-22 02:08 PM
DAK
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Cast 23-Sep-22 02:09 PM
Metaphysics i forgot how crazy that shit is (edited)
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Netizenne
I’ve started to think about engaging my internal unconscious (my brain) the way I do my external unconscious (you guys). If I just talk about what I want enough the unconscious will take interest, latch on, and get to work.
veganpermanently 23-Sep-22 02:09 PM
it's not my experience tho
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Cast 23-Sep-22 02:09 PM
Ive been tourmented by demons several times
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Netizenne
I’ve started to think about engaging my internal unconscious (my brain) the way I do my external unconscious (you guys). If I just talk about what I want enough the unconscious will take interest, latch on, and get to work.
Doctor Bonk 23-Sep-22 02:09 PM
this is similar to my study technique
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veganpermanently 23-Sep-22 02:09 PM
talking about stuff seems to make it less likely to happen
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Doctor Bonk 23-Sep-22 02:10 PM
but i moreso trick the unconscious through false association
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MEE6 BOT 23-Sep-22 02:10 PM
@Doctor Bonk, you have advanced to lvl 2 respect++ emoji_51
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veganpermanently 23-Sep-22 02:10 PM
it's likely I was spawned in an extra high difficulty territory tho'
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Cast 23-Sep-22 02:10 PM
Lol rip
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veganpermanently
talking about stuff seems to make it less likely to happen
Netizenne 23-Sep-22 02:10 PM
It’s like when meditating you can repeat a mantra sometimes and then you leave the brain silence. Make sure to leave silence I guess, too much talking can be bad
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Netizenne
I’ve started to think about engaging my internal unconscious (my brain) the way I do my external unconscious (you guys). If I just talk about what I want enough the unconscious will take interest, latch on, and get to work.
JK 23-Sep-22 02:10 PM
I'm serious, would be cool to research this further. Some forms of tibetan buddhism, do this through personified phenomena etc. (edited)
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Cast 23-Sep-22 02:11 PM
Do you believe in meta intelligences @veganpermanently
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Cast
Do you believe in meta intelligences @veganpermanently
veganpermanently 23-Sep-22 02:11 PM
I don't wanna meta about it (edited)
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Cast 23-Sep-22 02:11 PM
Like formed from the amalgamtion of the unconscious thoughts of us all
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Doctor Bonk
but i moreso trick the unconscious through false association
JK 23-Sep-22 02:11 PM
How so?
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Cast 23-Sep-22 02:11 PM
I think they form demons
14:11
And can antagonize us. Especially through dreams
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Netizenne
It’s like when meditating you can repeat a mantra sometimes and then you leave the brain silence. Make sure to leave silence I guess, too much talking can be bad
Netizenne 23-Sep-22 02:11 PM
When meditating on a mantra there has to be a certain power behind it, a hook that echoes even when you release the mind into full relaxation. (edited)
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Cast
I think they form demons
veganpermanently 23-Sep-22 02:12 PM
did u ever reach Satan
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JK
How so?
Doctor Bonk 23-Sep-22 02:12 PM
I attribute the emotions/state of mind that lead my conscious thinking to the things I want my consciousness to form around until there's no dissonance and enter the tao
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veganpermanently 23-Sep-22 02:12 PM
that mofo
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veganpermanently
did u ever reach Satan
Cast 23-Sep-22 02:12 PM
Maybe
14:12
He tempts me
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Cast
He tempts me
veganpermanently 23-Sep-22 02:13 PM
no those are the lesser demons
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Cast 23-Sep-22 02:13 PM
The demon entered my dream 2 days ago
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Doctor Bonk
I attribute the emotions/state of mind that lead my conscious thinking to the things I want my consciousness to form around until there's no dissonance and enter the tao
JK 23-Sep-22 02:13 PM
You are gonna have to eli5 this to me
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Cast 23-Sep-22 02:13 PM
Raped and humiliated me
14:13
Worst energy ive ever felt
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veganpermanently 23-Sep-22 02:13 PM
ye lesser demon
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Cast 23-Sep-22 02:13 PM
Also weirr
14:13
He tempted me with candy
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veganpermanently 23-Sep-22 02:14 PM
Satan will provide way worse emotional experience (edited)
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Cast 23-Sep-22 02:14 PM
He wanted me to give in to my cope
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veganpermanently 23-Sep-22 02:14 PM
but no eventful experience (edited)
14:14
only pure suffering
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Cast 23-Sep-22 02:14 PM
Damn
14:14
I dont think ive had that yet
14:15
I dont fuck with candy anymore ngl this dream fucked me up
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JK
You are gonna have to eli5 this to me
Doctor Bonk 23-Sep-22 02:15 PM
ig i just make myself happy when doing things i don't like until i no longer perceive a barrier between my like/dislikes
14:15
i sometimes do this poorly and end up gaslighting myself
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Cast 23-Sep-22 02:15 PM
@veganpermanently i feel like christinity is real
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Doctor Bonk
ig i just make myself happy when doing things i don't like until i no longer perceive a barrier between my like/dislikes
JK 23-Sep-22 02:15 PM
No but the concept makes sense
14:15
i get it
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Cast 23-Sep-22 02:15 PM
Via metaphysics
14:16
Like people unconsciously manifesting the bible and its outcome
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JK
No but the concept makes sense
Doctor Bonk 23-Sep-22 02:16 PM
its a divine tier learning technique
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Cast 23-Sep-22 02:16 PM
And the rise of so many satanist liberals
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Cast
I dont think ive had that yet
veganpermanently 23-Sep-22 02:16 PM
there's a reason why hell is depicted like a fiery place. because fire is formless. but it burning your skin is one of the worst sensations in the world. it's a good metaphor
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Cast
@veganpermanently i feel like christinity is real
Netizenne 23-Sep-22 02:16 PM
Gnostic Christianity has cool elements of truth to it too imo
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JK 23-Sep-22 02:16 PM
It's one way of reaching tao yes
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Netizenne
Neoteny is the ideal path of our evolution
Yana 23-Sep-22 02:16 PM
Tom Thumb
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veganpermanently
there's a reason why hell is depicted like a fiery place. because fire is formless. but it burning your skin is one of the worst sensations in the world. it's a good metaphor
Cast 23-Sep-22 02:17 PM
What do you think?
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Cast
@veganpermanently i feel like christinity is real
veganpermanently 23-Sep-22 02:17 PM
I'm not Christian I think it can help some people but it's not the truth
14:17
it's a delusion
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Cast 23-Sep-22 02:17 PM
I think the hivemind is real bro
14:17
And that many gods can form as a result of ones belief
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Cast
I think the hivemind is real bro
veganpermanently 23-Sep-22 02:17 PM
that's what the illuminati wants you to believe
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Cast 23-Sep-22 02:18 PM
Big organizations are all sentient
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JK
It's one way of reaching tao yes
Doctor Bonk 23-Sep-22 02:18 PM
my fav way of reaching the tao is to just notice the transience of things until it feels like water moving through my life. its simple but very effective and consistent
14:18
all it takes is a few seconds
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Cast 23-Sep-22 02:18 PM
Mcdonalds is fuckin sentient meta consciousness
14:18
Literally all organizations of humans are
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veganpermanently 23-Sep-22 02:18 PM
they will strip away freewill from you in one way or the other
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Cast 23-Sep-22 02:18 PM
Yes i know
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Cast
Mcdonalds is fuckin sentient meta consciousness
Yana 23-Sep-22 02:18 PM
Do I even want to know what you mean by this
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Cast 23-Sep-22 02:18 PM
Tik tok is getting strong as fuck
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Yana 23-Sep-22 02:19 PM
(I do)
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Yana
Do I even want to know what you mean by this
Cast 23-Sep-22 02:19 PM
Think about this
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Cast
Mcdonalds is fuckin sentient meta consciousness
veganpermanently 23-Sep-22 02:19 PM
this I can fw
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Cast
Tik tok is getting strong as fuck
Doctor Bonk 23-Sep-22 02:19 PM
bomb the hq
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Cast 23-Sep-22 02:20 PM
Imagine we are cells. Skin cells. And a higher entity is a scientist. He uses a microscope and for no particular reason at all he starts poking at a single cell. That cell is you (edited)
14:20
I feel like this analogy explains how it can seem like youre being antagonized by a higher force
14:20
Since you literally kind of are
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Cast
Imagine we are cells. Skin cells. And a higher entity is a scientist. He uses a microscope and for no particular reason at all he starts poking at a single cell. That cell is you (edited)
Yana 23-Sep-22 02:21 PM
Yeah sometimes I feel like I'm getting poked and hear voices. I am a targeted individual and being gangstalked
Prayge 1
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Cast 23-Sep-22 02:21 PM
Thats schizo but
14:21
Honestly im 100% starting to believe these metaphysical theories (edited)
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Cast
Big organizations are all sentient
Yana 23-Sep-22 02:22 PM
Sounds like something Nick Land would say
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Doctor Bonk 23-Sep-22 02:22 PM
believe in yo self Prayge
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Doctor Bonk
my fav way of reaching the tao is to just notice the transience of things until it feels like water moving through my life. its simple but very effective and consistent
JK 23-Sep-22 02:22 PM
Beautiful thought process, i tend to think of the lack of ownership to get me there.
Prayge 1
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Cast 23-Sep-22 02:22 PM
Collective intelligence my guy
14:22
Even this discord server is slightly a hivemind lol
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Netizenne 23-Sep-22 02:22 PM
I believe in higher levels of self aware systems and panpsychism (edited)
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Doctor Bonk 23-Sep-22 02:23 PM
man u cant call every organizational structure a hivemind
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Cast 23-Sep-22 02:23 PM
The more influence the more powerfuk it becomes
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Doctor Bonk
man u cant call every organizational structure a hivemind
Cast 23-Sep-22 02:23 PM
Every one that involves humans in groups
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Doctor Bonk 23-Sep-22 02:23 PM
the hive is downstream bigbrain
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Cast
Like people unconsciously manifesting the bible and its outcome
Yana 23-Sep-22 02:23 PM
This is the entire basis of magick
👍 1
14:23
Christ was one of the best magicians ever
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Cast 23-Sep-22 02:24 PM
Christ could have literally been real
14:24
Like actual God
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Netizenne 23-Sep-22 02:24 PM
Fairy tales provide us models for how to perceive and react to situations.
Prayge 1
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Cast
Christ could have literally been real
veganpermanently 23-Sep-22 02:24 PM
fake news
14:24
muslims are right
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Doctor Bonk 23-Sep-22 02:24 PM
god shoulda remained mythological
14:24
it was best for society
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Cast 23-Sep-22 02:24 PM
Im trying to hack this shit
14:25
Also u know whats even more fucked
14:25
The bigger the hivemind the harder it is to control.
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Netizenne
Fairy tales provide us models for how to perceive and react to situations.
Netizenne 23-Sep-22 02:25 PM
Should little red riding hood have reacted to the smooth talking man in the woods in fear or awe? Tell the tale one way or another for enough generations and you can make the fear of men baked into our culture seem only natural (edited)
👍 1
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Netizenne
Fairy tales provide us models for how to perceive and react to situations.
Doctor Bonk 23-Sep-22 02:25 PM
This is the basis behind Aesops fables
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Cast 23-Sep-22 02:25 PM
China could literally just target me for no reason lol
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Doctor Bonk 23-Sep-22 02:25 PM
I loved reading sour grapes as a kid, rlly stuck in me as an exmaple of dissonance
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veganpermanently 23-Sep-22 02:25 PM
Jesus was a messenger
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Doctor Bonk
This is the basis behind Aesops fables
Yana 23-Sep-22 02:25 PM
This is the basis of writing
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veganpermanently 23-Sep-22 02:26 PM
he never ressurected
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Yana 23-Sep-22 02:26 PM
Every religion has their thoth/mercury (edited)
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veganpermanently 23-Sep-22 02:26 PM
he didn't die for our sins
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JK 23-Sep-22 02:26 PM
Words are magick
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Netizenne
Should little red riding hood have reacted to the smooth talking man in the woods in fear or awe? Tell the tale one way or another for enough generations and you can make the fear of men baked into our culture seem only natural (edited)
Netizenne 23-Sep-22 02:26 PM
We are plastic, malleable, programmable to many arbitrary ways of perceiving, believing, and behaving
14:26
Probably to a degree far beyond what we recognize honestly
14:26
Far far beyond what we recognize (edited)
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Doctor Bonk 23-Sep-22 02:26 PM
the infinite beauty of a never ending psy op
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Netizenne
Should little red riding hood have reacted to the smooth talking man in the woods in fear or awe? Tell the tale one way or another for enough generations and you can make the fear of men baked into our culture seem only natural (edited)
Cast 23-Sep-22 02:26 PM
Psyops lol
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Netizenne 23-Sep-22 02:27 PM
The more K-selected the more malleable
Kekw 1
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Cast 23-Sep-22 02:27 PM
Psyops create entities lol
14:27
Feminsim was a combination of psysops which led to the hive mind ill call lilth
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Netizenne
The more K-selected the more malleable
Netizenne 23-Sep-22 02:27 PM
Slow life history strategists are defined by their reliance on parental (and in humans case cultural) investment
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Cast 23-Sep-22 02:28 PM
Im hella k selected
14:28
Ive never followed the crowd ive always been based
💀 1
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Cast
Ive never followed the crowd ive always been based
judas 23-Sep-22 02:29 PM
My brother that’s the opposite of K-selected traits
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Netizenne 23-Sep-22 02:29 PM
Western ways are degenerating the reproductive abilities of the Asians (the slowest life history strategists) the most. They aren’t instinctual animals, they rely on fables and tradition to guide them and tell them how to behave.
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Cast
Psyops create entities lol
JK 23-Sep-22 02:29 PM
The personification of internal or meta phenomena is definitely valuable. Name it to tame it
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judas 23-Sep-22 02:30 PM
The personification of your meta phenomenon into a psychological entity perhaps a alternate persona who can take control of you body at will
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Cast 23-Sep-22 02:30 PM
I personify them because they act intelligently
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Netizenne 23-Sep-22 02:30 PM
"finally showed that intranasal oxytocin (vs matching placebo) reduced analytical reasoning, and increased holistic processing, divergent thinking and creative performance." Oxytocin slow life history strategists parental investment molecule. Believing whatever and being hypnotizable is very powerful!!!!!
975869691522326638 1
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judas
The personification of your meta phenomenon into a psychological entity perhaps a alternate persona who can take control of you body at will
JK 23-Sep-22 02:30 PM
Is that what is it considered a Tulpa? (edited)
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Cast
Ive never followed the crowd ive always been based
Netizenne 23-Sep-22 02:31 PM
That sounds more r-selected K-selected are social creatures, conformist creatures Like the Japanese (edited)
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JK
Is that what is it considered a Tulpa? (edited)
Cast 23-Sep-22 02:31 PM
Getting weird
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JK
Is that what is it considered a Tulpa? (edited)
judas 23-Sep-22 02:31 PM
Tulpas are just DID alters for schizos who don’t want to admit they have alters (edited)
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JK
Is that what is it considered a Tulpa? (edited)
veganpermanently 23-Sep-22 02:32 PM
how is all of this superstitious shi not considered childish (edited)
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judas
Tulpas are just DID alters for schizos who don’t want to admit they have alters (edited)
JK 23-Sep-22 02:32 PM
I was just about to say
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judas 23-Sep-22 02:32 PM
Looking for some K-selected baddies to join my harem cult
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veganpermanently
how is all of this superstitious shi not considered childish (edited)
JK 23-Sep-22 02:32 PM
Oh it is
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Netizenne
That sounds more r-selected K-selected are social creatures, conformist creatures Like the Japanese (edited)
Cast 23-Sep-22 02:32 PM
Oh then im r selected as hell
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JK 23-Sep-22 02:33 PM
As written above, there is immense functionality with regards to conceptualizing internal or "meta" stuff
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judas
Tulpas are just DID alters for schizos who don’t want to admit they have alters (edited)
veganpermanently 23-Sep-22 02:33 PM
I don't think it's schizo it's just childish
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Netizenne
"finally showed that intranasal oxytocin (vs matching placebo) reduced analytical reasoning, and increased holistic processing, divergent thinking and creative performance." Oxytocin slow life history strategists parental investment molecule. Believing whatever and being hypnotizable is very powerful!!!!!
judas 23-Sep-22 02:33 PM
All of Andrew Tate’s fans are K-selected
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JK
As written above, there is immense functionality with regards to conceptualizing internal or "meta" stuff
Cast 23-Sep-22 02:33 PM
Shits weird
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JK 23-Sep-22 02:33 PM
But the line has to be drawn imo in terms of you are concious about it or not
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judas
All of Andrew Tate’s fans are K-selected
Cast 23-Sep-22 02:33 PM
Fr
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veganpermanently
how is all of this superstitious shi not considered childish (edited)
Netizenne 23-Sep-22 02:33 PM
I believe the malleability of the human mind goes far, far beyond what people realize That these tulpas and demons could be cptsd-like impressions of traumatic meditation -like carving the shape of an entity into your brain (edited)
Image attachment
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Cast 23-Sep-22 02:33 PM
My friend is a bot lol
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judas
All of Andrew Tate’s fans are K-selected
veganpermanently 23-Sep-22 02:33 PM
that's such a paradox tho
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Cast 23-Sep-22 02:33 PM
Andrew tate calling people bots when all his followers are bots
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veganpermanently 23-Sep-22 02:34 PM
I'm slippy
14:34
I trained my circadian rhythm right
14:35
should prolly start taking moda at the same time each day tho
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Netizenne
I believe the malleability of the human mind goes far, far beyond what people realize That these tulpas and demons could be cptsd-like impressions of traumatic meditation -like carving the shape of an entity into your brain (edited)
Cast 23-Sep-22 02:35 PM
This man talking about neurolink?
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Netizenne
I believe the malleability of the human mind goes far, far beyond what people realize That these tulpas and demons could be cptsd-like impressions of traumatic meditation -like carving the shape of an entity into your brain (edited)
judas 23-Sep-22 02:35 PM
Can’t wait for that 2 million digit span
REAL 1
Prayge 1
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Netizenne 23-Sep-22 02:35 PM
Oxytocin will help me be more creative, more plastic, more capable of building a tulpa
Kekw 1
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judas
Can’t wait for that 2 million digit span
veganpermanently 23-Sep-22 02:36 PM
that's gonna cost ya
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Netizenne
Oxytocin will help me be more creative, more plastic, more capable of building a tulpa
veganpermanently 23-Sep-22 02:36 PM
is that an affirmation
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Cast 23-Sep-22 02:36 PM
I had a similar thought i just didnt know it could be implemented like that
14:36
Thats insane i want this
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veganpermanently 23-Sep-22 02:36 PM
now this is really turning into a religion
PepeCigar 2
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Netizenne 23-Sep-22 02:37 PM
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veganpermanently
that's such a paradox tho
judas 23-Sep-22 02:37 PM
Yeah because he’s R-selected preying on Misogynistic normative tropes to garner attention , fame and money from the K-selected
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Netizenne 23-Sep-22 02:37 PM
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veganpermanently 23-Sep-22 02:37 PM
we need to build structures to make naturally forming hierarchies obsolete
Kekw 1
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Cast 23-Sep-22 02:37 PM
Tech + the human brain would provide immeasurable increase to intelligence
14:37
Only if i could get an implant now
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veganpermanently 23-Sep-22 02:38 PM
bahaism did a good job IIRC
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veganpermanently
is that an affirmation
Netizenne 23-Sep-22 02:38 PM
Affirmation of?
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veganpermanently 23-Sep-22 02:38 PM
as did all big religions but not the cults
14:38
which is I think the diff between a religion and cult
14:38
cult has one entity at the top
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Netizenne 23-Sep-22 02:39 PM
Jesus only spoke the truth, his most talented disciples transcribed it and made a book of it (edited)
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veganpermanently 23-Sep-22 02:39 PM
religion is delegated from an abstract entity
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veganpermanently
we need to build structures to make naturally forming hierarchies obsolete
judas 23-Sep-22 02:39 PM
Create a fascist police state for the sole purpose of forcing citizens to take Intranasal oxytocin everyday and then dissolve the state once the deed is finished. Then there is no hierarchy because everyone is too busy vibing. ( this backfires because their K-selected nature makes them fall in love with the centralized hierarchy itself ) (edited)
👌 4
Trollnt 3
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veganpermanently
cult has one entity at the top
Cast 23-Sep-22 02:39 PM
Like a pyramid scheme
14:40
Cults are highly intelligent
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Cast
Cults are highly intelligent
veganpermanently 23-Sep-22 02:40 PM
we just proved that with the emoji shit
14:41
just made a meme
14:41
roflmao
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Cast
Oh then im r selected as hell
Netizenne 23-Sep-22 02:41 PM
We still need to traumatize you till your even more so, remember????
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veganpermanently
just made a meme
Doctor Bonk 23-Sep-22 02:41 PM
yall get the morse code i sent?
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MEE6 BOT 23-Sep-22 02:41 PM
@Doctor Bonk, you have advanced to lvl 3 respect++ emoji_51
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Cast 23-Sep-22 02:41 PM
Also like that makes me think hiveminds could be like more or less intelligent depding on the functionality
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Doctor Bonk
yall get the morse code i sent?
veganpermanently 23-Sep-22 02:41 PM
no there was too much interference
Feelsbadman 1
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Doctor Bonk
yall get the morse code i sent?
JK 23-Sep-22 02:42 PM
Was that you?
14:42
you are getting swatted in 5
14:42
sorry
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Cast 23-Sep-22 02:42 PM
If scientology was as big as mcdonalds then scientology would be way more powerful
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Doctor Bonk 23-Sep-22 02:42 PM
SunglassesFlushed
14:43
should i go hide in a box (edited)
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JK
you are getting swatted in 5
veganpermanently 23-Sep-22 02:43 PM
981262939434659892
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Doctor Bonk 23-Sep-22 02:43 PM
and pretend im stuck in there
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JK 23-Sep-22 02:43 PM
nah
14:43
take your clothes off
14:43
wait for them
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Doctor Bonk 23-Sep-22 02:43 PM
bet
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judas 23-Sep-22 02:43 PM
I’m a sigma. I am R-selected while also having K-selected longterm life strategy but it’s because my prefrontal cortex works not because I care about some dumb shit like pairbonding. Smh Silly normies
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JK
take your clothes off
veganpermanently 23-Sep-22 02:43 PM
100% nood with a motorcycle helmet is the way to go
emoji_51 1
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Cast 23-Sep-22 02:44 PM
Im sigma schizo lol
14:44
Shrigma for sure
14:45
The truth
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Cast
If scientology was as big as mcdonalds then scientology would be way more powerful
Yana 23-Sep-22 02:45 PM
That's tautological. But they aren't big because they aren't
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Cast 23-Sep-22 02:45 PM
Is what i seek
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Netizenne 23-Sep-22 02:45 PM
doomshroom
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Yana 23-Sep-22 02:46 PM
How big they are is predicated on the memetic truth they provide
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Cast 23-Sep-22 02:46 PM
Hmm
14:46
Good point
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Yana 23-Sep-22 02:46 PM
Not EZ comparing a corporation to a clt
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veganpermanently 23-Sep-22 02:46 PM
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Cast
The truth
Netizenne 23-Sep-22 02:46 PM
The truth lies at the tipping point where 6.6666666666 converges on 7 -the unreachable ideal, the unending pursuit that may have never existed
14:46
7!!!!!
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Cast 23-Sep-22 02:46 PM
I guess i would say not more powerful
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Netizenne 23-Sep-22 02:47 PM
The sound of truth it rings
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Cast 23-Sep-22 02:47 PM
They just have a more manipulative personality
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veganpermanently 23-Sep-22 02:47 PM
new shrigma gif
14:47
good one
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Cast 23-Sep-22 02:47 PM
Mcdonalds to me is like a parent. That just feeds people.
14:47
But the dark side is gluttony
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Cast
Mcdonalds to me is like a parent. That just feeds people.
Yana 23-Sep-22 02:47 PM
Mitochondria to the cell is like a parent and the other organelles are beta
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Cast 23-Sep-22 02:48 PM
And encouragement of unhealthy comfort
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veganpermanently 23-Sep-22 02:48 PM
Image attachment
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Cast 23-Sep-22 02:48 PM
Its instilled through psyops as kids (edited)
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Cast
And encouragement of unhealthy comfort
Yana 23-Sep-22 02:48 PM
Warhol
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Cast 23-Sep-22 02:48 PM
Lets be honest
14:49
Mcdonalds is mid and designed to appeal to the largest crowd possible
14:49
Sounds contradictory but
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Yana 23-Sep-22 02:49 PM
https://www.youtube.com/watch?v=h8EqMCrtLZ0
MemeAnalysis
Psychology of Fast Food and Fat
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Cast 23-Sep-22 02:49 PM
The happy meal psyop
14:49
Instilled in our minds
14:49
Make me think it represents a parental provider in many minds
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Yana
https://www.youtube.com/watch?v=h8EqMCrtLZ0
Cast 23-Sep-22 02:51 PM
Image attachment
14:51
Classic
14:51
Algorithms be like
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Cast
Algorithms be like
veganpermanently 23-Sep-22 02:52 PM
retarded
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Doctor Bonk 23-Sep-22 02:52 PM
we r all data cattle
14:52
Trollnt
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Doctor Bonk
we r all data cattle
veganpermanently 23-Sep-22 02:52 PM
not for long
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Cast 23-Sep-22 02:52 PM
975869370045722694
14:52
We are sheep
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veganpermanently
not for long
Doctor Bonk 23-Sep-22 02:52 PM
EVil
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Cast 23-Sep-22 02:53 PM
Need 220 Iq to escape the matrix
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Doctor Bonk 23-Sep-22 02:53 PM
time to go do my 'self' programmed behaviors BusinessPepe
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Cast 23-Sep-22 02:53 PM
Fuck the psyops and the entities im going recluse
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Doctor Bonk
time to go do my 'self' programmed behaviors BusinessPepe
Cast 23-Sep-22 02:53 PM
Gl my lil wage slave
14:54
Ngl this convo is getting too meta
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Cast
Need 220 Iq to escape the matrix
Netizenne 23-Sep-22 02:54 PM
Need govt money and friends to share a house with to (edited)
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Cast 23-Sep-22 02:54 PM
I wanna escape this matrix
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Netizenne
Need govt money and friends to share a house with to (edited)
Cast 23-Sep-22 02:54 PM
Lul
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Cast
I wanna escape this matrix
JK 23-Sep-22 02:55 PM
U will
14:55
with your enthusiasm
14:55
it's just a matter of time lol
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Cast 23-Sep-22 02:55 PM
I should manifest being the first man to get chipped and use my cybernetic IQ to escape the matrix (edited)
🤣 1
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JK
with your enthusiasm
Cast 23-Sep-22 02:56 PM
Hell yea
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Doctor Bonk 23-Sep-22 02:56 PM
there was never a matrix
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Cast 23-Sep-22 02:56 PM
Ive been neural annealing so fuckin hard
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Doctor Bonk 23-Sep-22 02:56 PM
they tricked us into a diametry again
14:56
Trollnt
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Netizenne
Need govt money and friends to share a house with to (edited)
veganpermanently 23-Sep-22 02:56 PM
u don't need money but my house is too small sorry
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Cast 23-Sep-22 02:57 PM
Illuminati
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veganpermanently
u don't need money but my house is too small sorry
Netizenne 23-Sep-22 02:57 PM
And in Europe!!! So far away!!
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Cast 23-Sep-22 02:57 PM
They are meta asf
14:57
They made up the illuminati meme
14:57
To make it seem like a joke
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Netizenne
And in Europe!!! So far away!!
Doctor Bonk 23-Sep-22 02:57 PM
ahhemm
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Cast 23-Sep-22 02:57 PM
So they could make it fall out of relevancy and go undercover
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Doctor Bonk 23-Sep-22 02:58 PM
Hugzy
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Netizenne
And in Europe!!! So far away!!
veganpermanently 23-Sep-22 02:58 PM
big caves are creepy
14:58
I have that condition u know
14:58
I get dizzy in big indoor spaces
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Cast 23-Sep-22 02:59 PM
Im definetly gonna get gangstalked soon if i keep talking about this shit lol
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veganpermanently
I have that condition u know
Cast 23-Sep-22 02:59 PM
U seem the ghost cave vid? (edited)
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veganpermanently
I get dizzy in big indoor spaces
Netizenne 23-Sep-22 03:00 PM
Only cozy lil hobbit holes bless Prayge
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Cast 23-Sep-22 03:00 PM
https://youtu.be/ReYbrlG4BAU
Exploring Abandoned Mines and Unusual Places
The Horton Mine: Encountering a Ghost in a Haunted, Abandoned Mine ...
15:00
This cave is fucked
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Netizenne
Only cozy lil hobbit holes bless Prayge
veganpermanently 23-Sep-22 03:00 PM
myess
15:00
+1 if they move
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veganpermanently
+1 if they move
Netizenne 23-Sep-22 03:01 PM
Magic moving hobbit holes? Waow (edited)
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veganpermanently 23-Sep-22 03:01 PM
+5 if they're lined with thick iron tho
15:01
can't make up my mind
15:01
I'll have both eventually prolly
15:01
but need to choose one for now
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Cast 23-Sep-22 03:03 PM
Wonder what made that chain swing (edited)
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Cast
Wonder what made that chain swing (edited)
veganpermanently 23-Sep-22 03:03 PM
ur mom
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Yana 23-Sep-22 03:16 PM
@Cast they mcdonald's arch is breasts
15:16
m-m-m-mama/mcdonalds
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Netizenne 23-Sep-22 03:17 PM
How bad would it be to consume moldy nasal spray?
15:17
I’m prepping my cere nasal spray rn
15:17
I just rinsed the bottle with isopropyl
15:17
I’ll give it a sec to dry then put the cere in
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Netizenne
How bad would it be to consume moldy nasal spray?
veganpermanently 23-Sep-22 03:18 PM
bad
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Yana 23-Sep-22 03:18 PM
>it's real https://qz.com/745681/the-strange-freudian-design-of-mcdonalds-golden-arches/
The strange, Freudian design of McDonald’s golden arches
In the 1960s, a marketing design consultant insisted that the arches stood for “mother McDonald’s breasts.”
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veganpermanently 23-Sep-22 03:18 PM
pig brains tho
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Netizenne 23-Sep-22 03:18 PM
Pig brains are full of protein right? Probably good substrate for mold you think? (edited)
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Yana
>it's real https://qz.com/745681/the-strange-freudian-design-of-mcdonalds-golden-arches/
veganpermanently 23-Sep-22 03:18 PM
reminds me of sirsa
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veganpermanently
reminds me of sirsa
Yana 23-Sep-22 03:19 PM
Image attachment
15:19
What do we have here
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Netizenne 23-Sep-22 03:19 PM
Boobmantine Holyshig
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Yana
What do we have here
veganpermanently 23-Sep-22 03:19 PM
was just thinking today
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Yana 23-Sep-22 03:20 PM
The adamantane group looks like a 🧢 and it has "bro" in the name
15:20
It is a fraternity
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veganpermanently 23-Sep-22 03:20 PM
how fucking redundant it is to add a phenyl group to the adamantane moiety
15:20
it's almost like the designer wanted it to be dopaminergic
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Netizenne
Boobmantine Holyshig
Yana 23-Sep-22 03:21 PM
Cyproheptadine structure (DO NOT RESEARCH)
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veganpermanently 23-Sep-22 03:21 PM
but it was another age
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veganpermanently
but it was another age
Yana 23-Sep-22 03:21 PM
peak russian science
😂 1
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Netizenne 23-Sep-22 03:21 PM
Uterus molecule (edited)
15:22
Btw guys my nasal spray method sounds good right?
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Netizenne
Uterus molecule (edited)
Yana 23-Sep-22 03:22 PM
I always thought it was a COCK - your anima is too powerful
😂 1
WAAHWAHH 1
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veganpermanently 23-Sep-22 03:22 PM
pervschizos
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Yana 23-Sep-22 03:23 PM
So is 5-ht2a and 5-ht1a antagonism phallic or yonic
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JK 23-Sep-22 03:24 PM
yonic drive-in
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Yana
So is 5-ht2a and 5-ht1a antagonism phallic or yonic
veganpermanently 23-Sep-22 03:25 PM
find a dual 5HT2a agonist 5ht1a antagonist I give u all of my treasure chests
15:26
ultrapsychedelic
15:26
metapsychedelic
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veganpermanently
find a dual 5HT2a agonist 5ht1a antagonist I give u all of my treasure chests
Yana 23-Sep-22 03:26 PM
That's not a thing!?
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veganpermanently 23-Sep-22 03:26 PM
psychedelic on steroids
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Yana
That's not a thing!?
veganpermanently 23-Sep-22 03:26 PM
theoretically it could be made
15:27
but hard to make it small enough to have good pharmacokinetics
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Netizenne 23-Sep-22 03:32 PM
Well I just put pig brain up my nose
15:32
Anyone else?
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Yana 23-Sep-22 03:34 PM
Do phytoneurotrophins exist?
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Yana
Do phytoneurotrophins exist?
veganpermanently 23-Sep-22 03:36 PM
no better
15:36
small molecules
15:36
big brains
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veganpermanently
she was so beautiful, so approachable in 2015 still
Potential 23-Sep-22 04:54 PM
I don't see it.
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Netizenne
The idea of dating people who’ve had many partners before you is kinda spook You know they have a tendency for moving on
Potential 23-Sep-22 04:59 PM
We as humans are constantly changing. If for no obvious other reason the relationship ended due to the people growing into different directions. You can see this all the time.
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Netizenne
I’ve started to think about engaging my internal unconscious (my brain) the way I do my external unconscious (you guys). If I just talk about what I want enough the unconscious will take interest, latch on, and get to work.
Potential 23-Sep-22 05:04 PM
''The law of attraction'' is just people doing R F V but not knowing how it works. 🧠 (edited)
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Potential 23-Sep-22 05:19 PM
https://www.sciencedaily.com/releases/2019/09/190912111018.htm
Bone, not adrenaline, drives fight or flight response
Adrenaline is considered crucial in triggering a 'fight or flight' response, but new research shows the response can't get started without a hormone made in bone.
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Gavin 23-Sep-22 08:36 PM
posted my stack in #stacks if anyone wants to give some feedback
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Netizenne 23-Sep-22 09:06 PM
https://open.spotify.com/playlist/5k1FT4QVr3mLYOmuMmyiI5?si=g27gPn8YT0mue2fdBN8vKw
Solnuit
Goldenwombat · Playlist · 90 songs
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21:06
Made this around grade 12
21:06
Summer nights
21:07
@veganpermanently what do you think about combining Cerebrolysin with pregnenolone
21:08
The ol spooky BDNF + gabaergic combo 💀
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Netizenne
@veganpermanently what do you think about combining Cerebrolysin with pregnenolone
veganpermanently 24-Sep-22 12:27 AM
crit dmg
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Potential
I don't see it.
veganpermanently 24-Sep-22 12:28 AM
she was meant for ME
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Pax1l 24-Sep-22 01:08 AM
https://www.nature.com/articles/nnano.2008.374
Carbon nanotubes might improve neuronal performance by favouring el...
Nature Nanotechnology - Carbon nanotubes can enhance the excitability of neurons by forming tight contacts with the cell membranes to favour electrical shortcuts between the distal and proximal...
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01:08
https://www.sciencedirect.com/science/article/abs/pii/S1549963414005632
Enhanced neuronal cell differentiation combining biomimetic peptide...
Carbon nanotubes are attractive candidates for the development of scaffolds able to support neuronal growth and differentiation thanks to their abilit…
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01:10
Carbon nanotubes can be synthesized and coadministered with peptides to provide a superconducting scaffold to support neuronal function and outgrowth
01:10
Artificial myelin
01:11
https://pubs.acs.org/doi/10.1021/acschemneuro.9b00522
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Pax1l
Carbon nanotubes can be synthesized and coadministered with peptides to provide a superconducting scaffold to support neuronal function and outgrowth
veganpermanently 24-Sep-22 01:11 AM
rather snort OPSCs
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Pax1l 24-Sep-22 01:11 AM
In this work, we have prepared diphenylalanine β- and γ-peptides and conjugated them to carbon nanotubes (CNTs). These hybrids were able to self-assemble into fibrillar dendritic structures enabling the growth of primary hippocampal cells and the modulation of their neuronal functions
01:12
Im going to add superconducting wires, and artificial extracellular matrix to my brain
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veganpermanently 24-Sep-22 01:12 AM
that's crazee
01:13
https://www.youtube.com/watch?v=-N4jf6rtyuw
Gnarls Barkley Official
Gnarls Barkley - Crazy (Official Video)
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Pax1l 24-Sep-22 01:13 AM
Have you ever heard of neural knitting
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veganpermanently 24-Sep-22 01:13 AM
no
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Pax1l 24-Sep-22 01:13 AM
There are self assembling peptides that form structures to support neuronal outgrowth
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veganpermanently 24-Sep-22 01:14 AM
makes sense
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Pax1l 24-Sep-22 01:14 AM
These actually form fibrils sheets or tubes that can support the incorporation of peptides
01:15
This functions as an extracellular matrix and peptides such as rada 16 or di-dihenylalanine form these structures
01:16
And this can incorporate carbon nanotubes, laminin peptides, bdnf motifs, spider fibroin motifs and this csn make an artificial extracellular matrix that can incorporate stemcells
01:17
And be implanted into the brain
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veganpermanently 24-Sep-22 01:17 AM
OP
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Pax1l 24-Sep-22 01:20 AM
Image attachment
01:20
With the right ammount of money
01:21
Soon I will be the most enhanced person alive
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Pax1l
Soon I will be the most enhanced person alive
veganpermanently 24-Sep-22 01:23 AM
roll the dice but know the price
01:24
https://www.youtube.com/watch?v=6POZlJAZsok
Grover Washington, Jr. - Topic
Just the Two of Us (feat. Bill Withers)
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Pax1l 24-Sep-22 01:25 AM
https://youtube.com/shorts/7BPZz7subCs?feature=share (edited)
Shadowz
~ KIRA ~ ROLLING IN THE DEEP - [AMV]
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veganpermanently 24-Sep-22 01:26 AM
@Pax1l I think you need a maecena
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Pax1l 24-Sep-22 01:26 AM
Yes
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veganpermanently 24-Sep-22 01:27 AM
or a separate and unrelated legal business that can be scaled which will feed your biohacking efforts with cash and the biohacking will feed it with the smarts
01:27
hard to find a maecena nowadays, everyone wants some direct benefit as in profit or a stake in the business
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Pax1l 24-Sep-22 01:28 AM
If they want a better brain they will need me
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veganpermanently 24-Sep-22 01:28 AM
sadly the age of enlightenment is over
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Pax1l 24-Sep-22 01:29 AM
Now we are in the age of dispair
01:29
People are constantly caught in the idea of iq and cognitive enhancement
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veganpermanently 24-Sep-22 01:30 AM
not yet
01:30
in a few def
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Pax1l 24-Sep-22 01:30 AM
People are willing to kill themselves because they are not smart
01:30
Look on 4chan and its everywhere
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Pax1l
People are willing to kill themselves because they are not smart
veganpermanently 24-Sep-22 01:30 AM
nah they kill themselves because they're not rich
01:30
I know so much rich people that are dumb & proud
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Pax1l 24-Sep-22 01:31 AM
They want to be rich
01:32
What if i told you this wouldnt be difficult to make
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veganpermanently 24-Sep-22 01:32 AM
the thing about rich people and smart people alike, they're miserable people unless they have a purpose they're filling
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Pax1l 24-Sep-22 01:33 AM
I want to be a biological android
emoji_52 1
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veganpermanently 24-Sep-22 01:33 AM
I don't think biohacking goals can be considered a life purpose
01:33
they're a means if anything
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veganpermanently
they're a means if anything
Pax1l 24-Sep-22 01:45 AM
No it means everything at the end of a string of your thoughts
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Pax1l
People are willing to kill themselves because they are not smart
Maestus 24-Sep-22 02:07 AM
People die for a lack of purpose. The unconscious has a thousand ways of snuffing out a meaningless existence with surprising swiftness. Carl Jung An ant infected by the cordyceps mushroom will climb to a high place meaninglessly to die, in order that in it's death the mushroom may propagate it's spores with the widest range optimally. The evolutionary drives of the species tramples mercilessly the individual who does not serve their purpose to the greater whole, for it is interest merely in longevity of the species. Resulting suicide ect. Then that desire for death may be seen from another perspective: it is a signal that the current way of things is not working at all, it is a desire for rebirth.
👍 1
02:08
Also; I'M BACK BITCHES
👍 1
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ibtisam.midlet 24-Sep-22 02:08 AM
i love dope
02:08
wanting is everything
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veganpermanently 24-Sep-22 02:08 AM
https://www.youtube.com/shorts/LPzu5gjYAf8
TricksyClips
Joe Rogan & Theo Von on Elon Musk & Mark Zuckerberg #joerogan #shorts
02:08
plot twist: they all megadose MIF1
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Maestus
Also; I'M BACK BITCHES
veganpermanently 24-Sep-22 02:09 AM
motherfucker pls
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veganpermanently
motherfucker pls
Maestus 24-Sep-22 02:19 AM
emoji_48
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Maestus
emoji_48
veganpermanently 24-Sep-22 02:20 AM
that's just the pronoun I prefer to receive and give
02:21
if u want me to title you with bitch okay I respect that
02:21
just saying
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Maestus 24-Sep-22 02:24 AM
You will refer to me as one whose bitch you are, just saying
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Maestus
You will refer to me as one whose bitch you are, just saying
veganpermanently 24-Sep-22 02:32 AM
nah u get blocked for that behavior
02:32
I was nothing but curteous you deserve something else but I'm not getting down to your dick sucking level
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veganpermanently
nah u get blocked for that behavior
Maestus 24-Sep-22 02:35 AM
I choose to have faith you are jesting in return. Otherwise lol wtf
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veganpermanently
I was nothing but curteous you deserve something else but I'm not getting down to your dick sucking level
Pax1l 24-Sep-22 02:41 AM
He has me
02:41
https://pubmed.ncbi.nlm.nih.gov/16549776/
Nano neuro knitting: peptide nanofiber scaffold for brain repair an...
Nanotechnology is often associated with materials fabrication, microelectronics, and microfluidics. Until now, the use of nanotechnology and molecular self assembly in biomedicine to repair injured brain structures has not been explored. To achieve axonal regeneration after injury in the CNS, severa …
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veganpermanently 24-Sep-22 02:47 AM
https://www.youtube.com/shorts/VrShOp-WNYA @ibtisam.midlet do you have more like this
onlyjayus
School Hacks 👩🏼‍🏫 w OnlyJayus - #Shorts
💟 1
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ibtisam.midlet 24-Sep-22 04:22 AM
10.1098/rstb.2021.0050 "results" force papers results section, to get what you can't in sci-hub
04:22
* induced lung regeneration AT2 cell Pulmonary alveolar force article that say a subs has induced what you want
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Cast 24-Sep-22 04:32 AM
Jesus
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ibtisam.midlet 24-Sep-22 05:16 AM
@veganpermanently
05:18
See what I found in decent silly channel
05:19
🤭
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Cast
Jesus
veganpermanently 24-Sep-22 06:28 AM
everything is about perception
06:31
it's not that nothing bad happens when you're in a good mood but you don't notice it because you are deficient in negative affect. also predatorial and parasitic minds prey on people that seem vulnerable enough. it is easy to ward them off just by holding your ground but it becomes overwhelming over time to constantly do this. My approach is to limit the amount of interactions esp with people that are like this but also in the public. Off grid monking all the way
06:33
if u need to use public space it's useful to look important, walk firmly, keep your suit clean, keep muscle tissue, etc.
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veganpermanently 24-Sep-22 06:45 AM
https://www.youtube.com/shorts/EUW6MFhcAbE
IMPAULSIVE Clips
😰 WHY MARKIPLIER REFUSES TO DRINK ALCOHOL #shorts
06:46
@ibtisam.midlet don't drink if you don't know your ALDH status. all the asian here too but it can happen in other races too
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Cast 24-Sep-22 07:42 AM
that rejection kinda woke me up ngl
07:42
even tho it was like the softest rejection
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Cast
even tho it was like the softest rejection
veganpermanently 24-Sep-22 07:43 AM
ignore?
07:43
that's the hardest rejection
07:43
I had a bad dream today too
07:43
shit was getting nook'd the sky was beautiful tho
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veganpermanently
that's the hardest rejection
Cast 24-Sep-22 07:44 AM
u sure
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veganpermanently
shit was getting nook'd the sky was beautiful tho
Cast 24-Sep-22 07:45 AM
Dude my dreams are so fucked
07:45
I havent mentally recovered from my trip to asia
07:45
I literally dream about it every fucking week
07:45
I just dream about being in the airport with my friends and navigating
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Cast
u sure
veganpermanently 24-Sep-22 07:46 AM
yeah
07:46
if they insult you it's their problem
07:47
if they do anything else it's clearly less harsh
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Cast 24-Sep-22 07:47 AM
I feel like im not mad I got rejected
07:47
Because she gave me a chance
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veganpermanently 24-Sep-22 07:47 AM
but if they ignore that shi hurts
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Cast 24-Sep-22 07:47 AM
and I was too much of a loser to act on it
07:47
but I feel like I can un loser myself
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veganpermanently
but if they ignore that shi hurts
Cast 24-Sep-22 07:48 AM
I ignored her lol
07:48
so I equally deserved it but
07:48
I doubt shell give me another chance
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veganpermanently 24-Sep-22 07:48 AM
isn't that what I told u will happen
07:48
roflmao
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Cast 24-Sep-22 07:49 AM
idk lol
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veganpermanently 24-Sep-22 07:49 AM
see that's a prob
07:49
my dude
07:49
talk about pharmacology
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Cast 24-Sep-22 07:50 AM
oh yea that reminds me
07:50
I stil have one fucking package
07:51
should have came in yesterday
07:52
I got NAC now @veganpermanently
07:52
what will two capsules do for me
07:53
im also on 6000m of ashwagandha
07:53
two caps is 1200mg of nac
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veganpermanently 24-Sep-22 07:54 AM
@Netizenne I haave a new term for immortalists
07:54
eternalites
07:54
and for deathists
07:54
finilites
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veganpermanently
eternalites
Yana 24-Sep-22 08:11 AM
That could get caught up in those who subscribe to eternalism tho
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Yana
That could get caught up in those who subscribe to eternalism tho
veganpermanently 24-Sep-22 08:11 AM
what's that
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veganpermanently
what's that
Yana 24-Sep-22 08:12 AM
General relativity + multiverse = all timelines already exist and already have existed
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veganpermanently 24-Sep-22 08:12 AM
that's some eckhart tolle shit
08:13
that's goofy
08:14
all of these superstitions try to build over reality to escape it's scarcity
08:14
it's a passive cope, all of it
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Cast 24-Sep-22 09:19 AM
@veganpermanently gad damnhttps://www.youtube.com/watch?v=S2PVsv2K1Bg&list=RDuGqum1FECHA&index=4
Steve Lacy - Topic
Bad Habit
09:19
the lyrics are wayy too relatable (edited)
09:20
"Bad Habit is a song about the missed opportunity to be with a girl we really liked. The girl liked him, he wanted her, but for some reasons he didn’t try hard enough. In the song Steve Lacy admits that he wished he knew she liked him, and he asks himself if it’s too late to try. "
09:23
I dont think its too late
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Cast
"Bad Habit is a song about the missed opportunity to be with a girl we really liked. The girl liked him, he wanted her, but for some reasons he didn’t try hard enough. In the song Steve Lacy admits that he wished he knew she liked him, and he asks himself if it’s too late to try. "
Netizenne 24-Sep-22 09:25 AM
https://youtu.be/n3UpLxH74uE
Paul McCartney - Topic
Dear Boy (Remastered 2012)
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JK 24-Sep-22 09:55 AM
@Cast write them down
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JK
@Cast write them down
Cast 24-Sep-22 10:08 AM
What down?
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JK 24-Sep-22 10:11 AM
dreams
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JK
dreams
Cast 24-Sep-22 10:12 AM
Ive been writing them down sometimes
10:12
This is like the 4th dream ive had about vacation
10:12
That place is in my head
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JK 24-Sep-22 10:13 AM
shift the placement
10:13
write them down!
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JK
shift the placement
Cast 24-Sep-22 10:13 AM
Wdym?
10:13
U think if i write it down ill stop dreaming about it?
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JK 24-Sep-22 10:14 AM
i know
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JK
i know
Cast 24-Sep-22 10:17 AM
I mean i already have but ill try
10:17
The plot is usually me and my friends going to some fucked up asain country like china and being a dystopia
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Cast
Ive been writing them down sometimes
Maestus 24-Sep-22 12:46 PM
Dream are messages from the deep.
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Cast 24-Sep-22 12:48 PM
Yeaaa...
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veganpermanently
eternalites
Netizenne 24-Sep-22 01:37 PM
Lol a fine term
13:37
Language can be fun to mess with
13:38
I get alotta satisfaction for coming up with some new name when I do
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Netizenne 24-Sep-22 01:52 PM
Last night I dreamt I had many more dogs than I do irl, and that they were all part angels with wings and everything. And we were driving through Italy after taking them to play hockey somewhere when the smaller ones flew out the window and were playing in the valley below (we were driving through the alps and their foothills northward) (edited)
13:52
The smaller ones were more like salamander fairy dragons than angels. Very much still dogs tho
13:52
They were super mischievous the small ones
13:53
Whereas the big one was an old tired noble soul who just won all the awards at hockey then spent his time restringing and being well behaved
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veganpermanently 24-Sep-22 01:53 PM
2000 mg Mg from food today
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Netizenne 24-Sep-22 01:55 PM
Magnesium doesn’t do anything for me unless it’s magtein
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Netizenne
Magnesium doesn’t do anything for me unless it’s magtein
veganpermanently 24-Sep-22 01:55 PM
food does
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ibtisam.midlet 24-Sep-22 01:55 PM
I don't feel less then 25grams
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Netizenne 24-Sep-22 01:58 PM
In my dream I remeber how free the dogs were flying out the car window, gliding over the highway cliff through the valley far below They weren’t supposed to but I let them get away with it cause I couldn’t help encourage the playfulness of them. Then we drove back and forth down that stretch of the highway looking for them, waiting for them to fly back in
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Netizenne
In my dream I remeber how free the dogs were flying out the car window, gliding over the highway cliff through the valley far below They weren’t supposed to but I let them get away with it cause I couldn’t help encourage the playfulness of them. Then we drove back and forth down that stretch of the highway looking for them, waiting for them to fly back in
ibtisam.midlet 24-Sep-22 02:05 PM
I would like to get some cuteness in a dream
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Netizenne 24-Sep-22 02:05 PM
I don’t remember my dreams a lot
14:06
It’s cause I slept in or cause I had cere for the first time yesterday I think!!
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ibtisam.midlet 24-Sep-22 02:06 PM
Most of mine are enargyzic with travaling and stuff
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Netizenne 24-Sep-22 02:06 PM
I had another dream last night that’s a bit harder to explain
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ibtisam.midlet 24-Sep-22 02:09 PM
One time I took dxm dose and used internet for 2 hours then slept
14:09
dxm kicked in the dream
14:10
I was playing with waves of colors
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Netizenne
I had another dream last night that’s a bit harder to explain
Netizenne 24-Sep-22 02:15 PM
The setting was post apocalyptic, a deserted city. I’d arrived at some cluttered shops basement through a tunnel. Seemed European, or like a shop of antiques -very disorganized as though the owner were a serious horder. It was all dimly lit by oil lamps or something casting shadows through the piles of junk. The messiness of the clutter had a sort of coziness to it -like the way a mouse living in a house made of nick knacks below the floorboards of a house in a Disney movie does. Someone I’d known was murdered or gone missing there, and there was a strong sense of deja vu. Above the shop outside was a walled commune, a few blocks of the abandoned city made into a fort or refuge. (edited)
14:17
It was the liquified pig brains I bet (edited)
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Netizenne
The setting was post apocalyptic, a deserted city. I’d arrived at some cluttered shops basement through a tunnel. Seemed European, or like a shop of antiques -very disorganized as though the owner were a serious horder. It was all dimly lit by oil lamps or something casting shadows through the piles of junk. The messiness of the clutter had a sort of coziness to it -like the way a mouse living in a house made of nick knacks below the floorboards of a house in a Disney movie does. Someone I’d known was murdered or gone missing there, and there was a strong sense of deja vu. Above the shop outside was a walled commune, a few blocks of the abandoned city made into a fort or refuge. (edited)
ibtisam.midlet 24-Sep-22 02:27 PM
was it swithzerland
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ibtisam.midlet
was it swithzerland
Netizenne 24-Sep-22 02:27 PM
Couldn’t tell It was night, and I was mostly in the shop
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Netizenne
Couldn’t tell It was night, and I was mostly in the shop
ibtisam.midlet 24-Sep-22 02:31 PM
next time I'll go with you
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Netizenne 24-Sep-22 03:12 PM
IGFBP-3 is the most prevalent in adult serum with a concentration of around 100 nM/L, while all of the other IGFBPs are present at concentrations of less than 20 nM/L (25, 28). About 75–80% of serum IGFs were found in a ternary complex of about 150 kDa consisting of an IGF, IGFBP-3 (or less often IGFBP-5) and a glycoprotein called acid labile subunit (ALS). The remaining 20–25% of IGFs were complexed with one of the other IGFBPs (25, 28). Unbound IGFs have a half-life of less than 10 min (29). Binding to an IGFBP increases IGF half-life in the circulation to around 25 min, but the binary complexes are able to rapidly leave the circulation (29). Most of the circulating IGFs are present in the IGF-IGFBP3/5-ALS ternary complex (30, 31). The addition of ALS increases the molecular size of the complex and this has the effect of preventing the bound IGF from leaving the capillaries thereby confining it within the circulation (32). The ternary complex thereby greatly prolongs the half-life of bound IGFs to about 16 h or more, forming a long-lasting reservoir of IGFs in the circulation (28). Deletion of the ALS gene in mice results in a 60% reduction in circulating IGFs and a 15–20% reduction in postnatal growth (33).
https://www.frontiersin.org/articles/10.3389/fendo.2018.00117/full (edited)
Frontiers | IGF-Binding Proteins: Why Do They Exist and Why Are The...
Insulin-like Growth Factors (IGFs) are key growth-promoting peptides that act as both endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local tissues, most IGF molecules are bound by one of the members of the IGF binding protein (IGFBP) family, of which 6 distinct types exist. These proteins bind to IGF with an...
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Cast 24-Sep-22 03:34 PM
Lowkey developing hyper vigilance from my anxiety which is slightly raising my IQ (edited)
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Cast
Lowkey developing hyper vigilance from my anxiety which is slightly raising my IQ (edited)
Mnemonic Entity 24-Sep-22 03:36 PM
The key is to keep your stress hormone levels balanced along with increase of cholinergic tone to be able to increase digit-span/etc without anxiety Top-down cognitive scaffolding of coping mechanisms is also essential for preventing new synapses formed during the use of neurotropics from just contributing to anxious emotional phenotypes.
emoji_50 1
15:36
You gotta exercise, meditate, etc etc
15:36
I meditate 3x/day, just a simple do-nothing for 10-15 min
15:37
Although I catalyze with a Wim Hof breathing session to start the meditation
15:37
It's quite ironic that one of the most important cognitive skills is being able to stop cognition
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MEE6 BOT 24-Sep-22 03:37 PM
@Mnemonic Entity, you have advanced to lvl 3 respect++ emoji_51
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Netizenne 24-Sep-22 05:28 PM
@veganpermanently mr vesicle man!!!!!!
It has previously been shown that the production of C1P from sphingomyelin, by the joint action of sphingomyelinase and ceramide kinase, promotes Ca2+-dependent liposomal fusion, which enhances the vesicle fusion. Interestingly, C1P levels increase during phagocytosis, indicating that C1P may promote fusion between phagosomes and lysosomes [50], and in turn signifying that C1P regulates autophagosome-to-lysosome fusion as well. Given the role of CPTP in controlling intracellular C1P levels [41], CPTP may also control such fusion events. Moreover, a recent study suggests a role for sphingosine kinase 1 (SPHK1) and its product, S1P, in the endo-and exocytotic membrane trafficking pathways [51], which are tightly linked to the autophagic pathway [52, 53].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376959/
Autophagy in the light of sphingolipid metabolism
Maintenance of cellular homeostasis requires tight and coordinated control of numerous metabolic pathways, which are governed by interconnected networks of signaling pathways and energy-sensing regulators. Autophagy, a lysosomal degradation pathway by ...
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17:30
Sphingolipids are components of the cell membrane that help change it’s viscosity in order to make moving proteins and stuff embedded in it easier to move around across it. (Look up lipid rafts for more info) (edited)
17:30
Spingomyelin is elevated in ashkenazi
17:30
Ceramide is reduced and also seems to do bad stuff like cell death (edited)
17:31
As an essential component of cell membranes it seems to have taken up a pleiotropic role signalling that there’s enough building material for dendritic growth (something sphingomyelinase inhibitors cause).
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veganpermanently
@Netizenne I haave a new term for immortalists
Netizenne 24-Sep-22 06:26 PM
The infinitely ascending mountain and the tree of paths to the peak niche atop
18:30
The truth of the peak converging but never capping, the realm of paths refined
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Mnemonic Entity
The key is to keep your stress hormone levels balanced along with increase of cholinergic tone to be able to increase digit-span/etc without anxiety Top-down cognitive scaffolding of coping mechanisms is also essential for preventing new synapses formed during the use of neurotropics from just contributing to anxious emotional phenotypes.
Maestus 24-Sep-22 06:42 PM
This is especially insightful.
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MEE6 BOT 24-Sep-22 06:42 PM
@Maestus, you have advanced to lvl 3 respect++ emoji_51
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Netizenne 24-Sep-22 06:44 PM
Trading trails to truth, the minds the map and the model
18:45
refine refine reframe the mind
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Netizenne 24-Sep-22 07:00 PM
Nothing is perfect, nothing is godly Everything leads to nothing and nothing leads to everything
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Netizenne 24-Sep-22 07:14 PM
The infinite primary perpetually out of reach, the secondary stepping stones alleviate the beneath Taking goals of application show the short sighted, the paths nearby alighted
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Netizenne 24-Sep-22 08:01 PM
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Cast
im also on 6000m of ashwagandha
𝔘𝔵𝔨ü𝔩𝔩 24-Sep-22 09:04 PM
The anhedonia induction stack 💀
😂 1
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𝔘𝔵𝔨ü𝔩𝔩
The anhedonia induction stack 💀
veganpermanently 24-Sep-22 10:33 PM
it's kinda true
22:33
esp with kanna and NAC
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Cast 24-Sep-22 11:36 PM
Bruh i literally wake up with anxiety
23:37
Gotta sleep again
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Netizenne 24-Sep-22 11:38 PM
Jukesta you can’t let people dissuade your interest in things, a fascination with working memory or psychopathy might one day develop to a much deeper understanding even if others don’t see it (edited)
23:39
Stay golden!!!!!
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Cast 24-Sep-22 11:40 PM
Im done obsessing with shit like that until i touvh grass
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veganpermanently
esp with kanna and NAC
machineyadav 25-Sep-22 02:06 AM
Kanna + ashwagandha would be serotonin blast (edited)
02:06
Long term usage will downregulate ig
02:07
I wonder if kanna goes well with psychedelics or if it causes SS
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machineyadav
I wonder if kanna goes well with psychedelics or if it causes SS
veganpermanently 25-Sep-22 02:08 AM
I used megadoses with psilocin not implying it's safe, SS is rare but when it does happen it's life threatening or at least debilitating
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machineyadav 25-Sep-22 02:08 AM
I am on codeine today
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veganpermanently 25-Sep-22 02:08 AM
the trip was fine ah tho
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machineyadav 25-Sep-22 02:09 AM
One needs to keep cryproheptadine when using serotonergics
02:09
I got interested in lithium
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veganpermanently 25-Sep-22 02:09 AM
ye I agree
02:09
fck lith
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machineyadav 25-Sep-22 02:09 AM
Apparently chronic lithium use causes 10x intense psychedelics trip
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veganpermanently 25-Sep-22 02:09 AM
battery pacifier
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machineyadav 25-Sep-22 02:09 AM
200mcg LSD feels 2000mcg
02:10
One can use lsd microdose+ lithium microdose
02:10
10ug + 1 mg elemental lithium
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machineyadav
Apparently chronic lithium use causes 10x intense psychedelics trip
veganpermanently 25-Sep-22 02:10 AM
that would suggest a vulnerable brain state
02:10
low inhibitory/excitatory ratio
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machineyadav
One can use lsd microdose+ lithium microdose
veganpermanently 25-Sep-22 02:10 AM
that I'd fw
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veganpermanently
that would suggest a vulnerable brain state
machineyadav 25-Sep-22 02:11 AM
Lithium is like that
02:11
Very cool
02:11
And dangerous
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veganpermanently 25-Sep-22 02:11 AM
300 mcg should be fine
02:12
I'd use it daily
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machineyadav 25-Sep-22 02:12 AM
https://www.reddit.com/r/LSD/comments/an5qx4/lsd_and_lithium/
r/LSD - LSD and Lithium
19 votes and 3 comments so far on Reddit
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veganpermanently 25-Sep-22 02:12 AM
prolly I will
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machineyadav 25-Sep-22 02:12 AM
Very interesting post
02:12
*It is the dose that makes the poison.” -Paracelsus
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machineyadav
*It is the dose that makes the poison.” -Paracelsus
veganpermanently 25-Sep-22 02:13 AM
I wondered many times in my life what would happen if I microdose all of the poisons
02:13
like strichnine
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machineyadav 25-Sep-22 02:14 AM
Microsdosing strychhnine is very hard
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veganpermanently 25-Sep-22 02:14 AM
various venoms like bee, snake, frog, toad (edited)
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machineyadav 25-Sep-22 02:14 AM
I looked into it once
02:14
Riskier than datura
02:14
Strychhnine has one moiety which is pharmacologically good
02:15
Letme search the image
02:18
Image attachment
02:18
Dunno what that does but this is from paper of alkaloids that are anti fibrotic
02:19
There's no antidote for strychhnine yet
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MEE6 BOT 25-Sep-22 02:19 AM
@machineyadav, you have advanced to lvl 8 respect++ emoji_51
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machineyadav
Dunno what that does but this is from paper of alkaloids that are anti fibrotic
veganpermanently 25-Sep-22 02:20 AM
lel indole moeity wut
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machineyadav 25-Sep-22 02:21 AM
Oh indole
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machineyadav
I am on codeine today
veganpermanently 25-Sep-22 02:21 AM
why did u relapse and not justify your behavior
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veganpermanently
why did u relapse and not justify your behavior
machineyadav 25-Sep-22 02:21 AM
It's hard
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machineyadav
It's hard
veganpermanently 25-Sep-22 02:21 AM
what's not hard bro
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machineyadav 25-Sep-22 02:21 AM
I was only using tobacco
02:22
Then i found one tablet of codeine
02:22
Then took it
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veganpermanently 25-Sep-22 02:22 AM
don't continue at least
02:22
should have burned it tho
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machineyadav 25-Sep-22 02:22 AM
It's last tablet
02:22
I did 30 days of dxm to strengthen Dopamine system
02:23
Yet i am weak now
02:23
Chronic NMDA antagonist induces D2 synthesis and increases dopamine sensitivity
02:23
But it didn't last long
02:24
Looked up memantine as it has D2 agonist property
02:24
But it's weak
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machineyadav
Looked up memantine as it has D2 agonist property
veganpermanently 25-Sep-22 02:26 AM
it appears to have permanently obliterated cravings for Cannabis
02:26
I didn't smoke for months
02:27
and it's not like I'm trying either
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machineyadav 25-Sep-22 02:27 AM
I don't have issues with cannabis, cananbis is sometimes dysphoric for me
02:27
I am going to use cannabis soon for sleep
02:27
Until I collect money for better alternatives
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machineyadav
I am going to use cannabis soon for sleep
veganpermanently 25-Sep-22 02:28 AM
that's just dumb
☝️ 1
02:28
it's like using alcohol for sleep
02:28
it doesn't produce sleep
02:28
the architecture is all whacky
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veganpermanently
it's like using alcohol for sleep
machineyadav 25-Sep-22 02:29 AM
Alcohol is fucked up, at least cannabis increases deep sleep
02:29
Even though it decreases rem?
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machineyadav
Alcohol is fucked up, at least cannabis increases deep sleep
veganpermanently 25-Sep-22 02:29 AM
so does alc
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machineyadav
Even though it decreases rem?
veganpermanently 25-Sep-22 02:29 AM
SEVERELY
02:29
the worst nights were when I smoked a bunch before sleep
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machineyadav 25-Sep-22 02:29 AM
I saw paper showing lowered Adenosine from alcohol making more hard to sleep (edited)
02:30
So alcohol isn't that good
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veganpermanently 25-Sep-22 02:30 AM
so little stuff is good for sleep
02:30
melatoninergics
02:30
antiorexinergics
02:31
cholinergics in terms of REM
02:31
and indirect agents like berberine
02:31
zinc
02:31
vitamin c
02:31
hence my sleep stack
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machineyadav 25-Sep-22 02:32 AM
I ate lot of bacopa but it doesn't help sleep that much
02:32
Weird stuff
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machineyadav
I saw paper showing lowered Adenosine from alcohol making more hard to sleep (edited)
machineyadav 25-Sep-22 02:35 AM
It seems chronic alcohol does that
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judas 25-Sep-22 08:33 AM
@ibtisam.midlet do you know of any accessible D4 receptor agonists ?
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judas
@ibtisam.midlet do you know of any accessible D4 receptor agonists ?
ibtisam.midlet 25-Sep-22 08:36 AM
until I complete substance selectivity calculator +_+
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machineyadav
Alcohol is fucked up, at least cannabis increases deep sleep
blank 25-Sep-22 09:08 AM
??????????????? Still rapes overall sleep quality
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veganpermanently
hence my sleep stack
blank 25-Sep-22 09:09 AM
A2a agonists Shrekpardon
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blank
??????????????? Still rapes overall sleep quality
machineyadav 25-Sep-22 09:10 AM
Decreases time to fall asleep despite decreasing REM but limited by tolerance
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blank 25-Sep-22 09:10 AM
Why won't you just take melatonin/agomelatine and drink chamomile like normal people
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machineyadav 25-Sep-22 09:10 AM
Cause cheap, saving money rn
09:10
Investing all of it
09:11
15 cents for a edible (edited)
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blank 25-Sep-22 09:11 AM
How is weed cheaper for you than melatonin and chamomile
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machineyadav 25-Sep-22 09:11 AM
1 edible = 1 night sleep (edited)
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machineyadav
Until I collect money for better alternatives
machineyadav 25-Sep-22 09:11 AM
I will soon
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blank 25-Sep-22 09:11 AM
Surely you can find a raw melatonin powder source in Nepal it's like 1 cent a dose and will actually improve your sleep
😮 1
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blank
Surely you can find a raw melatonin powder source in Nepal it's like 1 cent a dose and will actually improve your sleep
machineyadav 25-Sep-22 09:12 AM
Maybe I can find it in India, but I need to cross border
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blank 25-Sep-22 09:12 AM
Chamomile should be really fucking cheap too
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machineyadav 25-Sep-22 09:12 AM
If it's available, I will give it a try
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machineyadav
I got interested in lithium
𝔘𝔵𝔨ü𝔩𝔩 25-Sep-22 09:52 AM
Li Orotate microdoses are pretty good, just picked some up from iHerb during their sale this weekend.
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MEE6 BOT 25-Sep-22 09:52 AM
@𝔘𝔵𝔨ü𝔩𝔩, you have advanced to lvl 3 respect++ emoji_51
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Potential 25-Sep-22 10:00 AM
@TreeSlayer Have you received NANA from Vitamondo yet?
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Potential
@TreeSlayer Have you received NANA from Vitamondo yet?
TreeSlayer 25-Sep-22 10:01 AM
Should be here next week, I'm in Arkansas and its in LA rn. So only a few more days
👌 1
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Cast 25-Sep-22 10:47 AM
Wtf happened to vegan
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Potential 25-Sep-22 11:03 AM
Wdym
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Potential
Wdym
Cast 25-Sep-22 11:03 AM
He just said this server was blue pilled and left
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Potential 25-Sep-22 11:04 AM
I know I'm going to be trialing it soon. (edited)
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Cast 25-Sep-22 11:04 AM
Btw u know anything about tak in nootopics?
11:05
Is the general consensus that it is a bust or success?
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Potential 25-Sep-22 11:05 AM
Success
11:05
It's a modern Piracetam
11:05
But
11:05
I have yet to try it
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Cast 25-Sep-22 11:06 AM
Have others reported increases in IQ other than sirsadalot
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Potential 25-Sep-22 11:06 AM
When I do, I can tell you my personal experience.
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Cast
Have others reported increases in IQ other than sirsadalot
Potential 25-Sep-22 11:06 AM
Yes.
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Cast 25-Sep-22 11:06 AM
By what margin?
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Cast
He just said this server was blue pilled and left
Potential 25-Sep-22 11:06 AM
He can do whatever he wants.
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Cast
By what margin?
Potential 25-Sep-22 11:07 AM
5-7 points on average.
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Cast 25-Sep-22 11:07 AM
Just wanted to know if there was some kind of argument or something
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Cast
He just said this server was blue pilled and left
Netizenne 25-Sep-22 11:08 AM
Where’d they say that? wait what noo (edited)
11:08
They’d just said this place was the cream of the crop just yesterday (edited)
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Potential 25-Sep-22 11:09 AM
@Netizenne Stop caring about others opinion.
11:09
He can do whatever he wants.
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Potential
@Netizenne Stop caring about others opinion.
Netizenne 25-Sep-22 11:09 AM
They have good insights and conversation tho
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Cast 25-Sep-22 11:09 AM
He sent me like a 2 page long essay on MGTOW using an analogy about coco cola marketing. And then he blocked me after i didnt follow his advice on becoming mgtw lol (edited)
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Netizenne
They have good insights and conversation tho
Potential 25-Sep-22 11:10 AM
He will come back most likely anyway. Not the first time he left.
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Cast 25-Sep-22 11:11 AM
He has issues underlying pain
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Netizenne 25-Sep-22 11:11 AM
We have to be more blackpilled Peeponotes
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Cast 25-Sep-22 11:11 AM
Based on his obsession with grimes
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Netizenne 25-Sep-22 11:11 AM
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Cast
Based on his obsession with grimes
Potential 25-Sep-22 11:12 AM
😂
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Cast 25-Sep-22 11:12 AM
I dont think he recovered fully from his last relationships
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Potential 25-Sep-22 11:12 AM
People come, people go. Reality of life.
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Cast 25-Sep-22 11:12 AM
He was telling me its not worth it and he put up with bullshit for years
11:12
I respect his pov but
11:12
Im still gonna try (edited)
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Netizenne 25-Sep-22 11:12 AM
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Potential 25-Sep-22 11:13 AM
You should. I found a worthy catch after one failure and she came to me.
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Potential
You should. I found a worthy catch after one failure and she came to me.
Cast 25-Sep-22 11:13 AM
Congrats
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MEE6 BOT 25-Sep-22 11:13 AM
@Cast, you have advanced to lvl 15 respect++ emoji_51
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Cast 25-Sep-22 11:13 AM
Im still trying i havent had good lucl
11:14
Ive got a tendency to push girls away from me if they come at me first
11:14
Stems from emotional attachment issues and low self esteem from highschool bullying
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Cast
Congrats
Potential 25-Sep-22 11:14 AM
She finds my obsession with taking over the world sexy.
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Cast 25-Sep-22 11:15 AM
Lol nice
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Netizenne
They have good insights and conversation tho
ibtisam.midlet 25-Sep-22 11:15 AM
I don't know really, I tryed to help him even revealing some critical secrets
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Netizenne 25-Sep-22 11:16 AM
If I don’t take it upon me to initiate, I don’t feel like I get any opportunities to talk to women. And I don’t initiate -so I just never speak to women cause they def don’t start conversation.
11:18
On the rare chance they do initiate, I have so little experience talking to them that I don’t have the practice to make use of that opportunity. I’ve only had girls approach me and show interest like once every 1-3 years.
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ibtisam.midlet 25-Sep-22 11:19 AM
@Netizenne I need headnotes see pm
11:20
About that subs
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Netizenne
On the rare chance they do initiate, I have so little experience talking to them that I don’t have the practice to make use of that opportunity. I’ve only had girls approach me and show interest like once every 1-3 years.
ibtisam.midlet 25-Sep-22 11:22 AM
They like who don't show interest in them
11:22
Which cause major logical problems
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Potential
She finds my obsession with taking over the world sexy.
Pax1l 25-Sep-22 11:33 AM
Image attachment
emoji_52 2
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Cast 25-Sep-22 12:47 PM
https://youtube.com/shorts/WPx91jcEtiI?feature=share
Jordan B Peterson Clips
Is Tinder a Gateway to Psychopathy for Popular Men? | Ben Shapiro &...
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Netizenne
On the rare chance they do initiate, I have so little experience talking to them that I don’t have the practice to make use of that opportunity. I’ve only had girls approach me and show interest like once every 1-3 years.
Potential 25-Sep-22 01:28 PM
If you don't have the experience then go out and get experience. Master the FORD method and you will be able to talk to anyone for any duration of time. When I was 18, I would go to random bars and just practice this method until everybody I met wanted to be my friend or something more. Once you master that method I could maybe teach you the VIPER method. A tweaked version of the FORD method that I invented which is infallible. Like the name suggests, this technique is deadly and plays around with how you are perceived.
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Potential
You should. I found a worthy catch after one failure and she came to me.
Nemo 25-Sep-22 03:09 PM
what mbti type is she?
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Nemo
what mbti type is she?
Potential 25-Sep-22 03:32 PM
I'm ENTJ,. she's INFJ
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Potential
It's a modern Piracetam
blank 25-Sep-22 03:33 PM
anecdotes seem to be pretty different though, to me tak is it's own entire thing
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blank
anecdotes seem to be pretty different though, to me tak is it's own entire thing
Potential 25-Sep-22 04:17 PM
We shall see.
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Shawn シ 25-Sep-22 06:17 PM
https://pocketoption.com/en/cabinet/
Login
Login to your Pocket Option account and earn while trading on financial markets.
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ibtisam.midlet 26-Sep-22 01:38 AM
https://youtu.be/cvaIgq5j2Q8
CUTLoveRx
Nightcore - Angel With A Shotgun
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Netizenne 26-Sep-22 01:53 AM
Chat will die without vegan ;_;
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Netizenne
Chat will die without vegan ;_;
ibtisam.midlet 26-Sep-22 01:54 AM
What we can do lol
01:54
I'm simping in his server
01:55
Let's see how he will react
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ibtisam.midlet
What we can do lol
Netizenne 26-Sep-22 01:55 AM
We go to their server instead maybe (edited)
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Netizenne
We go to their server instead maybe (edited)
ibtisam.midlet 26-Sep-22 01:56 AM
I don't think this good idea
01:56
You know why 😉
01:57
@veganprimate
01:57
He has multiple accounts here
01:57
Mr conversion
01:58
I act more better in other servers
01:58
Seems authority make me anxious
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Netizenne 26-Sep-22 01:59 AM
this server has a very free and chaotic feel that I like (edited)
01:59
like a designated hang out spot in an abandoned building lol (edited)
01:59
I think it’s all the degen stuff that contributes to it
02:00
And also how the channels are like a buncha disorganized chrome tabs looool
02:01
just makes it a free for all
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ibtisam.midlet 26-Sep-22 02:01 AM
we should ganerate a fight
Holyshig 1
haram 1
02:01
It bring members
02:01
Entertainment lol
02:02
Potential argue against this
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Netizenne 26-Sep-22 02:02 AM
Sacrifice the next noob to join Trollnt (edited)
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ibtisam.midlet 26-Sep-22 02:02 AM
I can't override his opinion
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Netizenne
Sacrifice the next noob to join Trollnt (edited)
ibtisam.midlet 26-Sep-22 02:02 AM
We should find a way to fix this editing problem
02:03
It make me feel bad
02:03
Looool
02:03
It was fixed before after 19grams omega 3 baby
02:04
I've found it inhibit worry in thought stream
02:04
Due to worry being useless emotion
02:04
Inhibition cause increase in processing accuracy
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Netizenne 26-Sep-22 02:06 AM
Gotta sleep gn
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ibtisam.midlet 26-Sep-22 02:06 AM
you can find alot of reports about omega 3 main effect being processing accuracy
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Netizenne
Gotta sleep gn
ibtisam.midlet 26-Sep-22 02:06 AM
you sleep a lot (edited)
02:07
comfortable dreams between ♥
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ibtisam.midlet
you can find alot of reports about omega 3 main effect being processing accuracy
Potential 26-Sep-22 04:08 AM
That is why I can't wait for LPC-DHA and LPC-EPA.
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Cast 26-Sep-22 08:42 AM
@macross89 hows it goin?
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macross89 26-Sep-22 08:42 AM
Good
08:42
Better than ever
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macross89
Good
Cast 26-Sep-22 08:45 AM
Still trying to psychopathy max?
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macross89 26-Sep-22 08:45 AM
No I'm trying to reintegrate myself into society and feel good wherever I go
08:46
Psychopathy can be obtained by simply feeling ok with yourself
08:46
Especially good of yourself
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macross89
Especially good of yourself
Cast 26-Sep-22 08:58 AM
As long as you have emotions you can always fall back down into a rut
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Cast 26-Sep-22 09:08 AM
U gotta escape the game bro
09:08
Psychopaths are free
09:09
It doesnt matter where they exist. It doesnt matter if they are ugly,poor or stupid
09:09
They just simply wont give a shit
09:09
Thats freedom
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Cast 26-Sep-22 09:24 AM
Some saw data
09:25
Need to find an ssri thats most effective for induction
09:25
Which will simulate maoaL
09:30
This is suicide without killing yourself
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Nemo 26-Sep-22 09:48 AM
@Cast
09:48
psychomaxxing compound: quercetin
09:48
isoquercetin better form
09:48
should lower oxytocin 😈
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Nemo
should lower oxytocin 😈
Cast 26-Sep-22 10:21 AM
Thats not psychopathy tho (edited)
10:21
Thatll just induce autism lol
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blank 26-Sep-22 10:24 AM
get lobotomized 👍
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blank
get lobotomized 👍
Cast 26-Sep-22 10:27 AM
Based lobotomy pilled
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Cast 26-Sep-22 10:42 AM
Pain is nootropic
10:44
Just typing constantly rn to occupy myself so i dont thinl about the paib
10:45
I live in regret
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Cast
Thats not psychopathy tho (edited)
Netizenne 26-Sep-22 01:56 PM
It’s low in psychopathy as well
13:57
I’d like to see an article on the oxytocin contents of autists CSF
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Netizenne
I’d like to see an article on the oxytocin contents of autists CSF
Cast 26-Sep-22 03:16 PM
Low
15:16
Or low oxytocin signaling
15:16
Im the first ever narcisistic autist (edited)
15:22
Maybe not ngl
15:22
Ive self diagnosed myself with almost every mental illness at some point
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Cast 26-Sep-22 03:51 PM
Image attachment
15:51
Oh boi
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Astora 26-Sep-22 04:19 PM
psychopaths are just high functioning autists
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Astora
psychopaths are just high functioning autists
Cast 26-Sep-22 04:23 PM
No
16:24
Psychopaths literally cannot be autistic
16:24
Otherwise they wouldnt have the brain damage required for psychopathy
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Astora 26-Sep-22 04:24 PM
false
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MEE6 BOT 26-Sep-22 04:24 PM
@Astora, you have advanced to lvl 1 respect++ emoji_51
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Astora
false
Cast 26-Sep-22 04:32 PM
Ive read that somewhere
16:32
I know one psychopath and 2 narcissists
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Astora 26-Sep-22 04:40 PM
maybe you should stop knowing them
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Astora
maybe you should stop knowing them
Cast 26-Sep-22 04:46 PM
I dont fuk wit them much
16:46
One of them actually used his manipulation powers to help me
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Astora 26-Sep-22 04:46 PM
explain?
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Cast 26-Sep-22 04:47 PM
But then i had to explain to him why we couldnt drive all the way out of town to drop him off
16:47
He just couldnt comprehend the level inconvience that would be
16:47
Last time i ever saw rhe dude
16:47
He would also just use peoples chargers without asking
16:48
And was notorious for stealing shit
16:48
He doesnt even think about whos it is he just sees a portable charger and uses it
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Astora
explain?
Cast 26-Sep-22 04:50 PM
I was on acid and my friend was screaming on newyears and i told him to shut up and pushed him. Then before a fight started the psychopath came in and calmed my friend down explaining to him it was just a symptom of lsd
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Astora 26-Sep-22 04:51 PM
?? Iol
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Cast 26-Sep-22 04:51 PM
Just a demonstration of his charisma
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Astora 26-Sep-22 04:51 PM
that's not epic psycho powers that's just him being decent to you for once
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Cast 26-Sep-22 04:52 PM
No it is
16:52
Hes highly charismatic
16:52
Everyone thought he was chill until people started realizing how much shit he steals
16:52
His borderline dysfunctional
16:52
Idk if he even drives yet he just lived in his last gfs house
16:53
But hes attractivd enough to get away with it
16:53
Me and my buddies were gonna buy weed from him and he kept cancelling lsst minute and changing shit
16:54
People didnt know how to explain it
16:54
They just said he was weird
16:56
I feel like i could be decent friends with him
16:56
He watches anime n shit hes not like antagonistic hes just a psychopath
16:56
Like yea i wont let him take advantage of me but
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N-C 26-Sep-22 06:00 PM
Hello
18:03
What’re y’all up to?
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N-C
What’re y’all up to?
Cast 26-Sep-22 06:11 PM
Psychopath maxxing
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N-C 26-Sep-22 06:12 PM
based psychopilled
18:13
What is this chat btw, I just joined cause I saw it in an about me
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Astora
psychopaths are just high functioning autists
blank 26-Sep-22 06:16 PM
that makes no sense, they are closer to opposites than anything
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N-C 26-Sep-22 06:16 PM
I’m a high functioning autist with psychopathy, what does that make me
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N-C
I’m a high functioning autist with psychopathy, what does that make me
Cast 26-Sep-22 06:17 PM
No ur not
18:17
Ur just austistic
18:17
Psychopaths cant be autistic
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N-C 26-Sep-22 06:17 PM
true dab
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MEE6 BOT 26-Sep-22 06:17 PM
@N-C, you have advanced to lvl 1 respect++ emoji_51
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Cast 26-Sep-22 06:18 PM
Take the kanna + ritalin pill
18:18
Essentially sustainable molly
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Pax1l
Click to see attachment 🖼️
Yana 26-Sep-22 06:19 PM
#paxrightagain
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Cast 26-Sep-22 06:19 PM
Molly is based for psychopathy maxxing
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N-C 26-Sep-22 06:19 PM
Wait is this chat discussing microdosing
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blank 26-Sep-22 06:19 PM
why is everyone suddenly being so obsessed about psychopathy just don't be an overly emotional bitch and you will be fine
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blank
why is everyone suddenly being so obsessed about psychopathy just don't be an overly emotional bitch and you will be fine
Cast 26-Sep-22 06:19 PM
Because i psyopted everyone
18:19
Get on the psychopathy train
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N-C 26-Sep-22 06:20 PM
psychopathy is not good, just fyi
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blank 26-Sep-22 06:20 PM
yeah
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N-C 26-Sep-22 06:20 PM
no remorse 💀
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Cast 26-Sep-22 06:20 PM
Not good for others
18:20
Great for u
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blank 26-Sep-22 06:20 PM
I genuinely have complete control over my empathy and most emotions in general
18:20
psychopathy just drains all meaning for life, that's why psychopaths do disgusting shit just to feel something
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N-C 26-Sep-22 06:21 PM
Yeah
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Cast 26-Sep-22 06:21 PM
Not rlly bro
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blank 26-Sep-22 06:21 PM
being able to move between emotional states is what actually matters
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N-C 26-Sep-22 06:21 PM
either that or that or need microscope to see pp /s
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Cast 26-Sep-22 06:21 PM
Pro social psychopathy is based
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Cast
Pro social psychopathy is based
blank 26-Sep-22 06:22 PM
and what the fuck even is that Kekw
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N-C 26-Sep-22 06:22 PM
no idea
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Cast
Low
Netizenne 26-Sep-22 06:22 PM
Show me the study!!!!!
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blank 26-Sep-22 06:22 PM
"I'm a prosocial autistic narcissist psychopath" -jukesta
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Netizenne 26-Sep-22 06:23 PM
And also neonatal doesn’t count
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blank
"I'm a prosocial autistic narcissist psychopath" -jukesta
Netizenne 26-Sep-22 06:23 PM
Frrr, bless Prayge
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N-C 26-Sep-22 06:23 PM
I’m an embryo with homocidal ideation how do I break free from this cage
bigbrain 1
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blank
and what the fuck even is that Kekw
Cast 26-Sep-22 06:23 PM
Pro social psychopaths are psychopaths that maintain a stable job and dont have a criminal record
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blank 26-Sep-22 06:24 PM
Ight (edited)
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Cast 26-Sep-22 06:24 PM
Basically ceos
18:24
Buisness boyos
18:24
Surgeons
18:24
Some doctors
18:24
Some cops
18:24
Women get wet af for psychopaths
18:25
They love the excitement
18:26
Iq isnt even shit anymore ngl
18:26
Well no
18:26
I take that back
18:26
psychopathy scales with IQ (edited)
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blank 26-Sep-22 06:27 PM
I guess some traits that arise from psychopathy are nice but you could just work towards those traits without self inducing psychopathy Kekw
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N-C 26-Sep-22 06:27 PM
yeah
18:27
like
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blank
I guess some traits that arise from psychopathy are nice but you could just work towards those traits without self inducing psychopathy Kekw
Cast 26-Sep-22 06:27 PM
As long as you have a soul you can falter
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N-C 26-Sep-22 06:27 PM
once you get past a certain point you won’t feel any remorse for your wrong doings and you’ll be wholly self-centered
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Cast 26-Sep-22 06:27 PM
Become souless
18:27
Nothing will phase you
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N-C
once you get past a certain point you won’t feel any remorse for your wrong doings and you’ll be wholly self-centered
N-C 26-Sep-22 06:28 PM
that’s not a good thing
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N-C
once you get past a certain point you won’t feel any remorse for your wrong doings and you’ll be wholly self-centered
Cast 26-Sep-22 06:28 PM
🥖
18:28
emoji_51
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Cast
Become souless
blank 26-Sep-22 06:28 PM
that's just cope
18:28
😹
18:28
Sticker
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Cast 26-Sep-22 06:28 PM
Its all mental
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blank 26-Sep-22 06:28 PM
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Cast 26-Sep-22 06:28 PM
No such thing as cope when cope is reality
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Netizenne 26-Sep-22 06:28 PM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719782/#!po=22.0000 Autists have normal CSF oxytocin levels. They do however have low vasopressin. … The effects of oxytocin and vasopressin on the HPA axis are opposing -so really they should have hpa axis activity more associated with high oxytocin (aka an oxytocin dominant hpa-axis phenotype). Low hpa axis activity and K-selected phenotype. However, -while oxytocin and vasopressin have opposing effects on the hpa axis, they have compiling effects on certain OT and vasopressin receptors. Vasopressin acts on V1, V2, V3, and oxytocin-type receptors (OTR). These are the receptors that modulate social salience iirc. So autism is low HPA activity (K-selected physical development) with low social salience. (edited)
Cerebrospinal Fluid Vasopressin and Symptom Severity in Children wi...
Autism is a brain disorder characterized by social impairments. Progress in understanding autism has been hindered by difficulty in obtaining brain-relevant tissues (eg, cerebrospinal fluid [CSF]) by which to identify markers of disease and targets for ...
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blank
Click to see attachment 🖼️
N-C 26-Sep-22 06:28 PM
it took me a picosecond
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Cast 26-Sep-22 06:29 PM
Molly effects me like it would a psychopath
18:29
Ive got perma oxytocin desensitivity
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bitchyblond2.0 26-Sep-22 06:29 PM
If you separate autism into clusters its actually genetically 3 different neurotypes that have the same phenotype
18:30
Not to mention different brain areas can look autistic or NT in different people
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bitchyblond2.0
If you separate autism into clusters its actually genetically 3 different neurotypes that have the same phenotype
N-C 26-Sep-22 06:30 PM
which one is most often attributed to Asperger’s?
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bitchyblond2.0 26-Sep-22 06:30 PM
Probably right psts (edited)
18:31
Poor use of tone of voice/facial expression data
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Netizenne
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719782/#!po=22.0000 Autists have normal CSF oxytocin levels. They do however have low vasopressin. … The effects of oxytocin and vasopressin on the HPA axis are opposing -so really they should have hpa axis activity more associated with high oxytocin (aka an oxytocin dominant hpa-axis phenotype). Low hpa axis activity and K-selected phenotype. However, -while oxytocin and vasopressin have opposing effects on the hpa axis, they have compiling effects on certain OT and vasopressin receptors. Vasopressin acts on V1, V2, V3, and oxytocin-type receptors (OTR). These are the receptors that modulate social salience iirc. So autism is low HPA activity (K-selected physical development) with low social salience. (edited)
Netizenne 26-Sep-22 06:31 PM
This changes how I think about things a lot actually.
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N-C 26-Sep-22 06:31 PM
I can’t look at people in the face for more than a second
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bitchyblond2.0 26-Sep-22 06:31 PM
If none of that shit makes sense it could lead you to rely on facts more maybe (edited)
18:32
Sorry right tpj is different than right psts
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N-C
I can’t look at people in the face for more than a second
Cast 26-Sep-22 06:32 PM
Brutal
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Cast
Brutal
N-C 26-Sep-22 06:32 PM
tbh sucks cause people think I’m ignoring them
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MEE6 BOT 26-Sep-22 06:32 PM
@N-C, you have advanced to lvl 2 respect++ emoji_51
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Cast 26-Sep-22 06:33 PM
Psycho max with me
18:33
U will be able to maintain indefinite eye contact.
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bitchyblond2.0 26-Sep-22 06:33 PM
Yeah people think you are retarded if you cant change the tone of your voice
18:33
A large percentage of people
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Cast 26-Sep-22 06:33 PM
No pressure no urgr to break eye contact
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bitchyblond2.0 26-Sep-22 06:33 PM
Or they are just confused generally
18:34
They assume you have mental issues
18:34
Retarded is a strong word
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N-C 26-Sep-22 06:34 PM
Is there any research on why having a GED is associated with a stigma towards mental issues?
18:34
like, I have a GED
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bitchyblond2.0 26-Sep-22 06:35 PM
When I think GED i think kid who smokes weed
18:35
Tbh
18:35
Could be smart
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N-C 26-Sep-22 06:35 PM
My situation just sucked
18:35
I have OCD which triggers suicidal ideation emoji_52
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bitchyblond2.0 26-Sep-22 06:36 PM
Try lithium orotate
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MEE6 BOT 26-Sep-22 06:36 PM
@bitchyblond2.0, you have advanced to lvl 1 respect++ emoji_51
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bitchyblond2.0 26-Sep-22 06:36 PM
Yooooo
18:36
Your baseline is zombified wagie who can afford nootropics and walgreens copay
18:36
Build from there
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N-C 26-Sep-22 06:37 PM
I have a prescription already it works for me I just wish I could play videogames
18:37
aside from just doing academic stuff
18:37
like
18:38
I try to play videogames then my brain basically says “bro, look at the health bar, it lost 1 point, kys”
18:38
really sucks it isn’t that drastic now, but fr I can’t play videogames without it being stressful
18:39
I really wish I had my issues diagnosed earlier
18:40
then I may have had a chance in HS
18:40
and wouldn’t have fucked myself over tbh
18:41
anyway, I don’t agree with self induced psychopathy
18:41
that’s putting yourself into an unhealthy position
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N-C
tbh sucks cause people think I’m ignoring them
blank 26-Sep-22 06:45 PM
you can get a lot better at it though
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N-C 26-Sep-22 06:45 PM
True
18:45
difficult though
18:46
Oh yeah can someone check something out real quick
18:47
I am working on a photo based tomography method
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blank
why is everyone suddenly being so obsessed about psychopathy just don't be an overly emotional bitch and you will be fine
Netizenne 26-Sep-22 07:08 PM
Cause d-serine is a promising drug to induce traits of it
19:09
Psychopaths create high quality social circles cause they’re willing to throw out terrible people regardless of whether or not they have tenure imo.
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N-C 26-Sep-22 07:10 PM
They also lack remorse
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Netizenne 26-Sep-22 07:10 PM
They keep a fine collection of characters
19:11
They have good charisma too. We empathize and instinctually feel what the people we’re talking to feel. That’s what empathy is -feeling what the people around us feel. Well psychopaths are fearless and lack insecurity. They don’t have built up fears about what to avoid doing and this and that. It is a nice feeling to be around disinhibited people, very fun to be around them. (edited)
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bitchyblond2.0
If you separate autism into clusters its actually genetically 3 different neurotypes that have the same phenotype
Netizenne 26-Sep-22 07:22 PM
I’d love to read more about different ways of subcategorizing autism if you have links??
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Netizenne 26-Sep-22 08:06 PM
Oxytocin as a mechanism underlying mammalian longevity and the Social Dependency Hypothesis Physiological and behavioral mechanisms that act to influence all forms of social support and create a context of psychological and emotional safety hold the potential to improve the quality of life and extend the lifespan [31]. As summarized below, oxytocin and its unique receptor, are particularly attractive candidates for central factors in social dependency and love [39,62,94] and the physiology of longevity [95]. Alternatively, factors such as early life stress, which hold the capacity to reduce the effects of the oxytocin system and epigenetically upregulate the vasopressin system, the hypothalamic-pituitary-adrenal axis and immune system may have the opposite consequences (reviewed [13,58,96]. https://www.sciencedirect.com/science/article/pii/S266649762100062X
 (edited)
Love and longevity: A Social Dependency Hypothesis
Mammals, including humans, are reliant for survival and reproduction on adaptations associated with sociality and physiological investment, which can …
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p2p expert 27-Sep-22 01:06 AM
How to make an app addictive so the user screen time goes to max 20 hours ?? (edited)
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p2p expert
How to make an app addictive so the user screen time goes to max 20 hours ?? (edited)
ibtisam.midlet 27-Sep-22 01:15 AM
launcher
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p2p expert 27-Sep-22 01:28 AM
What ??
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p2p expert
What ??
ibtisam.midlet 27-Sep-22 01:39 AM
like skinned nova launcher
01:39
if you intented to put a lot of ads then think of candy crash
01:43
any app usage can be increased just by adding crypto reward
01:44
nice now @p2p expert ?
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p2p expert 27-Sep-22 01:49 AM
I want to build an application that hooked people on screen for 20 hours a day , so how i do it ??
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ibtisam.midlet 27-Sep-22 01:49 AM
will you put ads
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MEE6 BOT 27-Sep-22 01:49 AM
@ibtisam.midlet, you have advanced to lvl 20 respect++ emoji_51
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p2p expert 27-Sep-22 01:50 AM
Ohk adservice , so yes
01:51
But customized ads not random ads
01:52
This app have reward system
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ibtisam.midlet 27-Sep-22 01:57 AM
the ad network will not give high CPM when it don't have much income to split for , targeting some lazy people is west of time, the probability of clicking ads and complete lead is so low compared to how it well targeting their pocket directly
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p2p expert 27-Sep-22 01:57 AM
1 ) short attentionspan 2 ) Free to use 3 ) notification alerts 4) lot's of contents ( video , audio , books and OTT) 5 ) crypto reward 6 ) share 7 ) inbuilt social media & dating , friendship, meet 8 ) inbuild cloud game 9 ) inbuild online shops 8 ) clean Ui/ux , easy to use (edited)
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MEE6 BOT 27-Sep-22 01:57 AM
@p2p expert, you have advanced to lvl 1 respect++ emoji_51
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ibtisam.midlet 27-Sep-22 01:57 AM
my opinion as a none ads logic
01:57
is making a gambling app
01:58
impossible to not success its not your opinion
02:00
you still want ads app?
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ibtisam.midlet
you still want ads app?
p2p expert 27-Sep-22 02:01 AM
Gambeling app are ban in lot of countries
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p2p expert
Gambeling app are ban in lot of countries
ibtisam.midlet 27-Sep-22 02:09 AM
means no competition if you in someway bypassed ban
02:12
for ads app see what I typed in first
02:13
That's what I can help with
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p2p expert
1 ) short attentionspan 2 ) Free to use 3 ) notification alerts 4) lot's of contents ( video , audio , books and OTT) 5 ) crypto reward 6 ) share 7 ) inbuilt social media & dating , friendship, meet 8 ) inbuild cloud game 9 ) inbuild online shops 8 ) clean Ui/ux , easy to use (edited)
ibtisam.midlet 27-Sep-22 02:23 AM
You have almost everything would all-in-on toolbox do, go ahead with it
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Mabus Tiefsee 27-Sep-22 03:12 AM
After the talks about IGF1 altering the brain, i retought if any of my behaviours or similar changed because of that. One came to my mind. Before i started that, i lacked the ability to feel stuff when i see it on video/anime/in storys and similar. However that changed slowly after i started taking IGF1, now i feel joy, anger, exitement and similar when i watch animes/listen to storys and similar. (this inabillity to feel that stuff was as strong, that i never understood why someone could cry/laught/fear/be exited while watching attack on titan, for me it was just an interesting story with great visuals) Could that be a side effect? Or unrelated?
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p2p expert
I want to build an application that hooked people on screen for 20 hours a day , so how i do it ??
Astora 27-Sep-22 07:22 AM
have you built any apps at all?
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p2p expert
I want to build an application that hooked people on screen for 20 hours a day , so how i do it ??
Mabus Tiefsee 27-Sep-22 08:26 AM
every predatory app tries that, farming games, facebook, twitter, all fail because we have to have a job. Make people earn real money and you solved the problem
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Cast 27-Sep-22 09:53 AM
Bruh
09:53
Psychopath maxxing is stupid
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Cast 27-Sep-22 10:06 AM
I just realized all my problems stem from internalized hatred of myself (edited)
10:07
Wanting to become more intelligent, unfeeling etc is just me practicing self hatred
✅ 1
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Cast
I just realized all my problems stem from internalized hatred of myself (edited)
macross89 27-Sep-22 10:15 AM
No shit
10:17
Bruh same for me
10:17
Problems all stem from self hatred
10:17
Which results in low confidence
10:17
Less sleep
10:17
Etc etc
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Cast
Psychopath maxxing is stupid
JK 27-Sep-22 01:48 PM
Glad you came around!
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macross89 27-Sep-22 02:01 PM
Yeah 😹
14:01
Lmao
14:02
Hahaha
14:02
Just break your amygdala and lose all emotions bro
14:02
emoji_50
14:03
Hahaha
14:09
Wtf
14:10
I just went into one channel and saw porn 🤣
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macross89
I just went into one channel and saw porn 🤣
blank 27-Sep-22 02:42 PM
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p2p expert
How to make an app addictive so the user screen time goes to max 20 hours ?? (edited)
Netizenne 27-Sep-22 04:53 PM
Always leave something around the corner for them to wait and stick around for maybe idk
16:54
Increase in game opportunities linearly along with how long of a streak they spend playing?
16:55
And always have something bigger around the corner (except for when they quit and put the game down for a few hours -then make it all reset).
16:56
After you’ve announced to the player there will be a reward so long as they stick around for a like 2-3 more minutes, it should pretty much be guaranteed (they don’t need to expend much effort, just stay glued). Or maybe not idk. (edited)
16:57
Idk if this chart is useful but maybe it’ll spark ideas
Image attachment
16:58
Look up operant conditioning
16:58
…
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Cast
I just realized all my problems stem from internalized hatred of myself (edited)
Netizenne 27-Sep-22 05:02 PM
Watched neon genesis? Lol
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Netizenne
Watched neon genesis? Lol
Cast 27-Sep-22 05:05 PM
nope whats that
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Cast
nope whats that
Netizenne 27-Sep-22 05:11 PM
Highly highly influential tv show
17:11
It’s about flesh golems and god
17:12
And post apocalyptic Japan
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Cast
nope whats that
𝔘𝔵𝔨ü𝔩𝔩 27-Sep-22 06:38 PM
watch it, we need an eva pilled jukesta
emoji_52 2
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macross89
Just break your amygdala and lose all emotions bro
Mabus Tiefsee 27-Sep-22 10:32 PM
🤔
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enui 27-Sep-22 10:44 PM
962885472382754877 hello
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enui
962885472382754877 hello
ibtisam.midlet 27-Sep-22 10:46 PM
hey
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Netizenne 28-Sep-22 12:12 AM
I’ve been conflating IGF 1 & 2 these past days
00:12
I should quit trying to manage a hobby like this and school at the same time
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Netizenne
I should quit trying to manage a hobby like this and school at the same time
ibtisam.midlet 28-Sep-22 12:23 AM
i was researching by phone in class in school :' )
00:23
look at me now
00:25
secondary school dropout
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Cast 28-Sep-22 04:03 AM
https://www.instagram.com/reel/CiNdNRSsvK2/?igshid=MTA0ZTI1NzA=
04:03
Lol this really is for me
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Netizenne
I should quit trying to manage a hobby like this and school at the same time
Mabus Tiefsee 29-Sep-22 09:44 AM
they both are similar, i would take any bet that igf1 activates igf2 receptors and the othet way arounf. Just a way weaker bond and not as efficient. Heck, even insulin activates those pathways, that's why some bodybuilders take insulin as doping
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Cast 29-Sep-22 01:17 PM
Just calculated that my personality type would be entj if i became a psychopath
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ibtisam.midlet 29-Sep-22 02:10 PM
🙁 https://youtu.be/_2pXh51X0iw
Bam
d21 update.
emoji_52 1
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le_drig 29-Sep-22 02:34 PM
9-me-bc any good?
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le_drig
9-me-bc any good?
ibtisam.midlet 29-Sep-22 03:01 PM
Its maoi a inhibitor might possess photo photosensitivity like harmaline seeds Doe's
15:02
See this, its dirty to all Target's you are interested in https://discord.com/channels/1001420842179239936/1001423075742601267/1025066685180416061
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ibtisam.midlet
🙁 https://youtu.be/_2pXh51X0iw
Cast 29-Sep-22 04:12 PM
Lol rip
16:13
Not a single one of these new nootropics has delivered
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ibtisam.midlet
🙁 https://youtu.be/_2pXh51X0iw
Yana 29-Sep-22 05:45 PM
https://www.sciencedirect.com/science/article/pii/S266717432200088X 975906197771272273
Daily THC and withdrawal increase dopamine D1-D2 receptor heteromer...
Frequent cannabis use is associated with a higher risk of developing cannabis use disorder (CUD) and other adverse consequences. In rodents, modeling …
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981262939434659892 1
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Cast 29-Sep-22 05:47 PM
Im always skeptical on noots increasing IQ
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Yana 29-Sep-22 05:47 PM
Also, where are these discussions he speaks of?
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Cast 29-Sep-22 05:48 PM
probably rocketchat
17:48
thats kinda sad tho since I was looking forward to d21
17:49
was that suppose to be the sticky working memory inducer he referenced in an earlier vid?
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Yana 29-Sep-22 05:50 PM
I mean nobody has really been talking about it let alone hyaluronate and stuff. Just waiting for updates
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Yana
I mean nobody has really been talking about it let alone hyaluronate and stuff. Just waiting for updates
Cast 29-Sep-22 05:52 PM
its really been in the works for so long
17:53
anything interesting on tak? I heard its a consistent 5 point IQ increase
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Yana 29-Sep-22 05:54 PM
Vaping increasing cd44 expression 🤔
17:54
TAK is worth a try
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ibtisam.midlet
🙁 https://youtu.be/_2pXh51X0iw
Netizenne 29-Sep-22 05:59 PM
rip
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MEE6 BOT 29-Sep-22 05:59 PM
@Netizenne, you have advanced to lvl 15 respect++ emoji_51
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Netizenne 29-Sep-22 06:01 PM
We need to master increasing head size imo
18:01
Learning how to restart cranial growth plates
18:02
And how to selectively increase growth at different parts of the skull (ofc we want a big head, but giant face might be undesirable) (edited)
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Netizenne
We need to master increasing head size imo
Cast 29-Sep-22 06:05 PM
for what purpose?
18:06
Also I dont think you can restart a growth plate when its fused to bone
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Cast
Also I dont think you can restart a growth plate when its fused to bone
Netizenne 29-Sep-22 06:16 PM
Worse case scenario we may need trepanation
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Netizenne
Worse case scenario we may need trepanation
Cast 29-Sep-22 06:16 PM
why do you think this is a good idea?
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Netizenne 29-Sep-22 06:18 PM
Someone in another chat sent this:
18:18
large amounts of stress delay growth plate senescence, people who have a stressful development can gain some ‘catch-up growth’ if the stress is gone in time https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445429/ The effect of glucocorticoid excess on growth plate senescence may provide an explanation for the phenomenon of catch-up growth. Catch-up growth is defined as a growth rate greater than is normal for chronological age following a period of growth inhibition [21]. Catch-up growth has been observed after a variety of growth-inhibiting conditions, including glucocorticoid excess, in humans and other mammals [21]. It has been suggested that catch-up growth might be caused by a neuroendocrine mechanism within the central nervous system that senses the child’s body size, compares that actual body size to an age-appropriate set point, and then adjusts the growth rate accordingly [22].
 (edited)
Effects of Glucocorticoids on the Growth Plate
Glucocorticoids have a direct, inhibitory effect on the growth plate, as demonstrated by in vivo and organ culture studies. Glucocorticoids slow longitudinal bone growth by inhibiting chondrocyte proliferation, hypertrophy, and cartilage matrix synthesis. ...
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18:20
It looks like people can recover from r-selection forcing them into becoming a fast life history strategist if they can escape stress soon enough. Fast life history strategists grow up faster -but sacrifice quality (so like stress for example can shorten height maybe). The ideal strategy in unstable environments full of unpredictable and unavoidable threats is to grow up and reproduce asap. (edited)
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Netizenne 29-Sep-22 07:44 PM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530787/
Brain IGFBP-5 Modifies the Relation of Depressive Symptoms to Decli...
Brain proteins, including Insulin-like Growth Factor Binding Protein 5 (IGFBP-5), have been associated with cognitive dysfunction in aging. Mechanisms linking depression with cognition are poorly understood. We hypothesize that the association of depressive ...
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19:45
how do we lower IGFBP5 without effecting the other IGFBPs as much
19:45
?
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Cast
Im always skeptical on noots increasing IQ
blank 29-Sep-22 07:50 PM
d21 wasn't even meant for IQ enhancement but go off
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Yana
https://pubmed.ncbi.nlm.nih.gov/16263982/ (edited)
Netizenne 29-Sep-22 08:36 PM
@Cast look at the conversation I’m replying to
to what purpose
IGF is part of the growth hormone axis. GH produces secretion of IGF, and then both cause growth (look up acromegaly to see an example of GH and IGF overexpression -makes people look like Andre the giant). Insulin-like growth factor (IGF) and insulin itself have both been found to be very associated with intelligence by many different means (both gene testing, exogenous administration, and other associative tests). Activation of insulin receptors cause energy use and growth. Insulin causes cells to take up glucose from the blood -which is the main fuel source used for growth which insulin receptors also cause. (edited)
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le_drig
9-me-bc any good?
𝔘𝔵𝔨ü𝔩𝔩 29-Sep-22 09:21 PM
A friend of mine likes it a lot, I'm going to be trying it starting next month.
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Netizenne 29-Sep-22 10:00 PM
https://twitter.com/MavenPolitic/status/1575559751500705797 Exactly what I’ve been trying to say
Author icon
Maven Politic (@MavenPolitic)
Hard times make properly socialised autists; Properly socialised autists make good times; Good times produce poorly socialised autists; Poorly socialised autists produce hard times. The Autistic conception of history. A thread 🧵
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Footer icon Twitter • 29-Sep-22 11:54 AM
22:01
This guy says it all perfectly
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PlayDough 30-Sep-22 01:18 AM
what are some good resources (books, textbooks, online guides) to effectively using nootropics? such as how to best use adderall or other stims and their underlying mechanisms of action etc i dont mind it its even a medical textbook
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PlayDough
what are some good resources (books, textbooks, online guides) to effectively using nootropics? such as how to best use adderall or other stims and their underlying mechanisms of action etc i dont mind it its even a medical textbook
ibtisam.midlet 30-Sep-22 01:22 AM
from Wikipedia you know standards and what keywords like "transporter" means, other online resource gives you what proteins function like this https://www.biotune.org/2019/07/what-receptors-do-antidepressants-and.html, until you advanced to understand research papers and the most important thing right now is experimenting and engaging in nootropics community like this
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Maestus 30-Sep-22 05:15 AM
"All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison." -Paracelsus
👆 1
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Yana
https://www.sciencedirect.com/science/article/pii/S266717432200088X 975906197771272273
veganpermanently 30-Sep-22 06:44 AM
we must find another solution
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Netizenne
I should quit trying to manage a hobby like this and school at the same time
veganpermanently 30-Sep-22 07:26 AM
biohacking will improve your study gains
07:26
I wish I had a hobby like this back in the day
07:27
we had weed, psychedelics and piracetam if you're extra resourceful
07:28
tho' I wasn't
07:28
975869370045722694
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Cast 30-Sep-22 08:12 AM
I can feel my anixety slowly returning the longer i wait to take ashwagandha
08:15
Im gonna need something stronger
08:20
Its done good but
08:20
Hm
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Netizenne
This guy says it all perfectly
veganpermanently 30-Sep-22 08:53 AM
https://www.youtube.com/watch?v=doOXWSXbRCc Mouse utopia is better model Two of the biggest issues with his most famous Mouse Utopia experiment were that the species of mice he used typically formed harems and the male mice kill the offspring of rivals. In nature, males tend to have a higher mortality rate, so there's less competition for mates, but without external forces to kill off the males, they were constantly fighting as they tried to form their own harems. So while there might have been plenty of food, there weren't enough females for the males giving their instinctual behavior. A species of mice that formed monogamist relationships would have done much better. As for males killing pups, the space offered no places to hide. In nature, females will find some hidden place that a rival male is unlikely to happen across. Without secluded spaces, females were constantly having to defend their young until they grew exhausted and abandoned them.
HowStuffWorks
The Rise of the Beautiful Ones - Science on the Web #114
08:54
we're living in the end stge ... u cn either embod the beutiful one or fight the other men. well... mbe not u 😛
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